Prepared: 02/015 University of California, San Diego Curriculum Vitae

Name: Teri Melese, Ph.D

Current Position: UCSD Assistant Vice Chancellor, Industry Research Alliances Adjunct Associate Professor, Department of Medicine and Rady School of Management

Last Position Held: Adjunct Associate Professor UCSF Department of Medicine, School of Medicine, 2005-2012 UCSF Dean’s Office: Director of Business Strategy and Development, School of Medicine UCSF Helen Diller Comprehensive Cancer Center Executive Committee: Associate Director for Strategic Alliances

Address: University of California, San Diego Office of Research Affairs 9500 Gilman Drive #0910 La Jolla, CA 92093-0043 Tel: (858) 822-5247 mobile: (408) 373-3651 [email protected]

Education: 1975-77 University of California, Berkeley A.B. Neurobiology/ Literature 1977-82 University of California, San Francisco Ph.D. Regents Fellow 1982-86 University of California, Los Angeles Postdoctoral Fellow Biochemistry 1986-87 University of California, Los Angeles American Cancer Sr. Research Fellow

Principal Positions Held: 1988-92 Columbia University, New York Assistant Professor Biological Sciences 1993-97 Columbia University, New York Associate Professor Biological Sciences 1997-99 Columbia University, New York Adjunct Associate Professor Biological Sciences 1997-01 Iconix Pharmaceuticals Mountain View Founding Member & Director Chemical Genomics 2001-2012 University of California, San Francisco Adjunct Full Professor Step II Medicine Present University of California, San Diego Assistant Vice Chancellor ORA

Other UCSF Positions Held Concurrently: 2001-2012 Helen Diller Comprehensive Cancer Center Assistant. Director, Strategic Alliances 2005-2012 School of Medicine Dean’s Office Director, Business Strategy and Development

Honors and Awards: 1977 UC Regents Fellowship (as graduate student, UCSF) 1979 Cystic Fibrosis Research Fellowship (as graduate student, UCSF) 1986-87 American Cancer Society Senior Postdoctoral Fellowship Award 1988-91 National Science Foundation 1989-92 March of Dimes 1990-94 NSF Presidential Young Investigator Award 1991-96 National Institutes of Health 2003 Opportunity Award UC Discovery Program/ Organized International Biotech Summit Meeting 2004-05 Special Opportunity Award UC Discovery Program/ Facilitation of Industry Partnerships 2007 UCSF CORO Leadership Class

Professional Organizations: Memberships: 2005-2012 BioPharma Council, Association of Strategic Alliance Professionals Service to Professional Societies: 2002 External Reviewer NCI SBIR program; February, 2002 2002-04 NCI Review Panel for FLAIR program SBIR/STTR drug development, Rockville Maryland 2003 Campus Wide Research Office UC Discovery Grant Review Panel 2004 NIH Review Panel for Planning Grants for AP4 Centers, March 2004 2004-05 Inter-SPORE Prostate Biomarkers Group (NCI) 2005 International Biotech Summit Planning Committee 2005 NIH AP4 Center Review Panel September 9-10 2005 2006 NCI Roundtable for the Translational Research Working Group, February 2006 2007 Reviewer for UC Davis NIEHS Superfund Grant (Proposed Technology Transfer/Partnering Program) 2012 Advisor; Partnering for Cures Conference

Service to Professional Publications: 1997/2004 Ad Hoc Reviewer for the Journal of , Molecular Cellular Biology, The Journal of Cell Science and Nature Cancer Center Reviews. 2009-2013 Ad Hoc Reviewer for Nature Biotechnology

Invited Presentations: 2000 Chairperson for the Workshop on Drug Discovery, Yeast Meetings July 25-30, 2000 Seattle Washington. 2002 Organizer of special Academic/Industry Panel held June 5, 2002, Herbst Hall, UCSF 2003 Invited Talk, November 2003, Preclinical Models of Breast Cancer, Sacramento CA 2005 Organized Panel Session for BIO2005 meeting (FDA, Eli, Pfizer, NCI, LBNL, Affymetrix, UCSF), Philadelphia 2006 Medical Futures Forum, Trust in Healthcare: Relationships between Scientists in Academia and Industry, New York 2006 Presentation to UC Discovery Executive Board, Berkeley 2006 UC Discovery Fellows Program Retreat, UC San Diego 2006 UC Discovery Fellows Program Retreat, UC Davis 2007 UC Davis Environmental Health Entrepreneurship Academy, Tahoe 2007 UC Davis School of Medicine Entrepreneurship Retreat, UC Davis 2007 UC Davis CTSC Executive Committee Meeting, UC Davis 2007 UC Discovery Fellows Program Retreat, UC Berkeley 2007 Association for Strategic Alliance Professionals, BioPharma Council 2008 UC Discovery Fellow Program Retreat, UC Santa Barbara 2008 Drug Discovery Dilemma Workshop: Navigating a New Paradigm, Georgetown University Organizers: Georgetown University, Pfizer, J& J, Novartis, Wyeth and Eli Lilly 2008 Association of Strategic Alliance Professionals, Partnering, Boston, Massachusetts 2009 BIO International Convention, Georgia World Congress Center, Atlanta, Georgia 2010 Institute Of Medicine Countermeasures Workshop, Washington DC 2012 Partnering for Cures, FasterCures; Panelist 2012 Cambridge Health Institute Strategic Alliance Management Congress; Chair of Session of Academic/Industry Partnerships 2012 Faster Cures TRAIN Workshop 2013 Alzheimer’s Drug Discovery Foundation; Panelist Academic/Industry Partnerships 2013 AUTM; Panelist New Partnering Models between Academia and Industry 2013 Association of University Research Parks (AURP): Panelist Building Partnerships at University Research Parks, Philadelphia 2013 World Biotechnology Conference: Moderator of Panel on Changing Impact of Academic/Industry Partnerships on Innovation, San Diego 2013 Partnering for Cures, Expert Consultant & Panelist Intellectual Property Intersection, New York 2013 Annual Meeting of the California Healthcare Institute (CHI): Panelist Nurturing Innovation in California, Genentech 2014 UCOP Invited Meeting, Bridging the PhD/Industry Employment Gap, Breakout Group Leader, IBM Almaden Research Center, San Jose 2014 Hartford Law Group Event: Panelist Funding Gap at University, SD Law Library, SD 2014 Global Innovation Summit “Dean”, San Jose 2014 Innovation Hub: Panelist Commitment to Commercialize Research: Taking a Lab Discovery to the Marketplace, Institute for the Americas, UC San Diego 2014 ASBMB: Panelist Building a sustainable research enterprise, San Diego Convention Center, San Diego 2014 Cambridge Healthtech Institute Strategic Alliance Management Congress: Moderator for Panel: Optimizing the Impact of Academic-Industry Alliances on Innovation, Philadelphia 2014 Blossom Wealth Management Flight to Freedom Summit for Entrepreneurs, Investors & Philanthropists; Speaker 2014 Faster Cures Workshop on University Foundation Relations: Invited participant, Boston MA 2014 Faster Cures Partnering for Cures: Expert Consultant 2014 2nd Annual Strategic Alliances Forum for Pharma: Speaker, Atlanta Georgia 2015 Global Innovation Summit “Dean”, San Jose 2015 XX in Health Retreat, Harvard Club, Leader Roundtable, New York 2015 SAGE BioCongress: invited participant, Institut Pasteur, Paris France

Courses Attended: 2004 Contemporary Planning Skills for Project Management (Stanford University Continuing Studies) 2004 Tools for Strategic Management (Stanford University Continuing Studies) 2004 Basic Financial Analysis for Strategic Marketing (Stanford University Continuing Studies) 2007 UCSF CORO Leadership Class

University and Public Service: System-Wide: 2011 RAP Technology Review Committee 2008-2011 Academic Senate Committee on Research 2008-2011 Academic Senate Committee on Academic Freedom 2004-05 Ad hoc member; UC Discovery Program, Executive Committee, Office of the President

UCSF Campus-Wide Committees: 2005-06 Vice-Chancellors Core Facility Planning Committee 2006 Vice-Chair of the Industry Alliance Coordinating Committee appointed by Gene Washington 2007 CTSI SOS Center Steering Committee 2007 Vice Chancellor’s Research Data Systems Steering Committee (RDSSC) 2007 Vice Chancellor’s Integrated Data Repository Data Ownership and Responsibility Working Group (Sub-committee of RDSSC) 2008-2011 Academic Senate Committee on Research 2008-2011 Academic Senate Academic Freedom Committee 2011-2012 RAP Technology Review Committee 2011-2012 LRDP Subcommittee and, Chair, Financial Working Group

UCSF School of Medicine: 2005 School of Medicine, Dean’s Office, Committee on Multi-Center Trials Committee 2005 School of Medicine, Dean’s Office, Committee for the Parnassus Heights Core Facilities 2006 School of Medicine Dean’s Office Representative Molecular Imaging Program Recruitment

Patents Filed at Iconix (1997-2001): 1 Method for Generating a Pathway Reporter System Teri Melese, Edward Perkins, Stuart Tugendreich USSN 09/475,412 2 Surrogate Genetics Target Characterization Method Keith Bostian, Georges Natsoulis, Teri Melese, Stuart Tugendreich, Edward Perkins, Raymond Kim USSN 09/306,709 3 Inhibitors of RhoC Stuart Tugendreich, Ed Perkins, Teri Melese and Dave Morgans US (USSN 09/952748, filed 9/14/01) PCT (US01/28610) 4 PARP Inhibitors Elaine Yeh, Ed Perkins and Teri Melese US (USSN 10/008358, filed 12/3/01) PCT (US01/46811) 5 Modulators of Phosphoinositide 3-Kinase Teri Melese, Ed Perkins, Allen Nguyen, Dongxu Sun USP (USSN 60/328481) USP (USSN 60/328486) USP (USSN 60/328503) USP (USSN 60/328480) USP (USSN 60/335464) USP (USSN 60/335172) USP (USSN 60/335167) USP (USSN 60/328438) USP (USSN 60/335245) USP (USSN 60/328610) USP (USSN 60/328470) USP (USSN 60/335461)

Publications: 1. Fraser, Heather, Marshall, Anthony and Melese,Teri : Reinventing Life Sciences: How emerging ecosystems fuel innovation, 2015 2. Fraser, Heather, Marshall, Anthony and Melese, Teri: Innovating Life Sciences; Lessons from Success, Innovation secrets from the world’s most successful life sciences companies 2015, in development. 3. Katherine A. Rauen, Anuradha Banerjee, W. Robert Bishop, Jennifer O. Lauchle, Frank Mccormick, Martin Mcmahon, Teri Melese, Pamela N. Munster, Sorena Nadaf, Roger J. Packer, Judith Sebolt-Leopold, And David H. Viskochil Costello and Cardio-Facio-Cutaneous Syndromes: Moving Toward Clinical Trials in RASopathies American Journal of Medical Genetics Part C (Seminars in Medical Genetics): 1-11, 2011. 4. Lorizio, W, Rugo, H, Beattie, M., Tchu, S.,Melese,T, Melisko, M.,Wu H.B.Alan, Lawrence, J. Nikoloff, M., and Ziv, E. Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment, Genome Medicine, 3: 64, 2011 5. Katherine A. Rauen, Lisa Schoyer, Frank McCormick, Angela E. Lin, Judith E. Allanson,David A. Stevenson, Karen W. Gripp, Giovanni Neri, John C. Carey, Eric Legius, Marco Tartaglia,Suzanne Schubbert, Amy E. Roberts, Bruce D. Gelb, Kevin Shannon, David H. Gutmann, Martin McMahon, Carmen Guerra, James A. Fagin, Benjamin Yu, Yoko Aoki, Benjamin G. Neel, Allan Balmain, Richard R. Drake, Garry P. Nolan, Martin Zenker, Gideon Bollag, Judith Sebolt-Leopold, Jackson B. Gibbs, Alcino J. Silva, E. Elizabeth Patton, David H. Viskochil, Mark W. Kieran, Bruce R. Korf, Randi J. Hagerman, Roger J. Packer, and Teri Melese. Proceedings From the 2009 Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back, American Journal of Medical Genetics (Part A): 1-21, 2009 6. Melese Teri, Lin Salima M., Chang Julia L. & Cohen Neal H. Open innovation networks between academia and industry: an imperative for breakthrough therapies 2009 Nature Medicine, Vol. 15: 502-507. 7. Vottero Eduardo, Balgi Aruna, Woods Kate, Tugendreich Stuart, Melese Teri, Andersen Raymond J, Mauk A Grant, and Roberge Michel. Inhibitors of human indoleamine 2,3-dioxygenase identified with a target- based screen in yeast. 2006 Biotechnology Journal, Vol. 1: 282-288. 8. Melese T. Building and Managing Corporate Alliances in an Academic Medical Center. 2006 Research Management Review, Vol 15-1. 9. Tugendreich Stuart, Perkins Ed, Couto Joe, Barthmaier Peter, Sun Dongxu, Tang Shawn, Tulac Suzana, Nguyen Allen, Yeh Elaine, Mays Amy, Lila Tom, Shivak David, Prichard Mark, Andrejka Laura, Kim Raymond and Melese Teri. A Streamlined Process to Phenotypically Profile Human cDNAs in Parallel Using Yeast Cell-based Assays. 2001 Genome Research, Vol. 11: 1899-1912. 10. Perkins, E., Sun, D., Nguyen, A., Tulac, S., Francesco, M., Tavana, H., Nguyen, H., Tugendreich, S., Barthmaier, P., Couto, J., Yeh, E., Thode, S., Jarnagin, K., Jain, A., Morgans, D. and Melese, T. Novel inhibitors of PARP1 and PARP2 identified using a cell-based screen in Yeast. 2001 Cancer Res. Vol. 61: 4175-4183. 11. Yan, Catherine, Leibowitz, Noah and Melese, Teri. A role for the divergent actin gene, ACT2, in nuclear pore structure and function. 1997 EMBO J. Vol. 16: 3572-3586. 12. Shan, Xiaoyin, Xue, Zhixiong, Euskirchen, Ghia and Melese, Teri. Nnf1 is an essential yeast gene required for proper spindle orientation nucleolar and nuclear envelope structure and mRNA export. 1997 Journal of Cell Science Vol. 110: 1615-1624. 13. Xue, Zhixiong, Shan, Xiaoyin, Sinelnikov, Alex and Melese, Teri. Yeast mutants that produce a novel type of ascus containing asci instead of spores. 1996 Genetics Vol. 144: 979-989. 14. Shan, Xiaoyin, Xue, Zhixiong and Melese,Teri. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. 1994 Journal of Cell Biology Vol. 126: 853-862. 15. Xue, Zhixiong, Shan, Xiaoyin, Lapeyre, Bruno and Melese, Teri. The amino terminus of mammalian nucleolin specifically recognizes SV40 T-antigen type nuclear localization sequences. 1993 European Journal of Cell Biology Vol. 62: 13-21. 16. Yan, Catherine and Melese, Teri. Multiple Regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus. 1993 Journal of Cell Biology Vol. 123: 1081-1091 17. Lee, Wen-Ching, Zabetakis, Daniel and Melese,Teri. NSR1 is required for pre-rRNA processing and for the proper maintenance of steady state levels of ribosomal subunits. 1992 Molecular and Cellular Biology Vol. 12: 3865-3871. 18. Lee, Wen-Ching, Xue, Zhixiong and Melese, Teri.The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifs. 1991 Journal of Cell Biology Vol. 113: 1-12. 19. Lee, Wen-Ching and Melese, Teri Identification and characterization of a nuclear localization sequence- binding protein in yeast. 1989 Proc. Nat’l. Acad. Sci. USA Vol. 86: 8808-8812. 20. Xue Zhixiong, Melese,Teri, Stempel, Kerstin, Reedy T.J. and Boyer, Paul D. Properties of chloroplast F1 ATPase partially modified by 2 azido adenine nucleotides, including demonstration of 3 catalytic pathways. 1988 J. Biol. Chem. Vol. 263: 16880-16885 21. Melese, Teri, Xue, Zhixiong, Stempel, Kerstin and Boyer, Paul D. Catalytic Properties of chloroplast F1 ATPase modified at catalytic or non-catalytic sites by 2-azido adenine nucleotides. 1988 J. Biol. Chem. Vol. 263: 5833-5840. 22. Zhou, Jun Mei, Xue, Zhixiong, Melese, Teri and Boyer Paul D. The relationship of tightly bound ADP and ATP to control and catalysis by the chloroplast ATP synthase. 1988 Biochemistry Vol. 27: 5129-5135. 23. Xue, Zhixiong, Zhou, Jun Mei, Melese,Teri, Cross, Richard L. and Boyer, Paul D, Accelerated Publication Chloroplast F1 ATPase has more than three nucleotide binding sites and both catalytic and non-catalytic sites are on or close to the ß-subunit. 1987 Biochemistry Vol. 26: 3749-3753 24. Melese, Teri and Boyer, P.D. Derivatization of the catalytic subunits of the chloroplast ATPase by 2-azido ATP and dicyclohexylcarbodiimide: Evidence for catalytically induced interchange of the subunits. 1985 J. Biol. Chem. Communication Vol. 260:15398-15401 25. Kanpal, Rajandra P., Melese, Teri, Stroop, Steven D. and Boyer Paul D. Mitochondrial F1 ATPase will bind and cleave ATP and slowly release products after DCCD or NBD-Cl derivatization of one subunit. 1985 J. Biol. Chem. Vol. 260: 5542-5547. 26. Melese,Teri and Rothman, Stephen S. Increased phosphate efflux from the acinar cell during protein secretion. 1983 Amer. J. Physiol. Vol. 244, Cell Section C121-C124 27. Melese, Teri and Rothman, Stephen S. Distribution of three hexose derivatives across the pancreatic epithelium: Paracellular shunts or cellular passage? 1983 Biochim. et. Biophysica. Acta Vol. 763: 212-219. 28. Melese, Teri and Rothman, Stephen S. The pancreatic epithelium is permeable to sucrose and inulin across secretory cells. 1983 Proc. Nat’l. Acad. Sci. USA Vol. 80, 4870-4874.

Reviews: 1. Melese, Teri and Hieter, Phil. From Genetics and Genomics to Drug discovery, Yeast Rises to the Challenge. 2002 Trends in Pharmaceutical Sci., Vol. 23: 544-547. 2. Melese, Teri and Xue, Zhixiong. The nucleolus: an organelle formed by the act of building a ribsome. 1995 Current Opinion in Cell Biology Vol. 7: 319-324. 3. Xue, Zhixiong and Melese, Teri. Nucleolar proteins that bind NLSs: a role in nuclear import or ribosome biogenesis? 1994 Trends in Cell Biology Vol. 4 414-417. 4. Melese, Teri. Analysis of nuclear envelope ATP-binding proteins. 1990 Academic Press, Inc. In: Biochemical and Structural Dynamics of the Cell Nucleus. Editors, Wang, E. Wang, J., Chien,S. Cheung, W-Y. and Wu, C.W. pp. 227-247. 5. Rothman, Stephen S. and Melese, Teri. “Leaky” cells of the glandular epithelia. 1988 International Review of Cytology Vol. 112: 225-244 6. Melese, Teri. The unfolding of a catalytic mechanism for the remarkable ATP synthase. 1985 Plenum Press In: Recent Advances in Biological Membrane Studies: Substructure and Biogenesis: Oxidation and Energetics. Editor, Parker, L. pp. 511-524.