SEAN J. ELLIOTT Department of - Boston University 590 Commonwealth Ave. - Boston, MA 02215 - (617) 358-2816 - [email protected] Updated 14 November 2013

Research Interests My research is focused on the redox chemistry of bioinorganic and enzymes: multi- electron catalysts, enzymes, and complex such as multi- c. For the past decade, I have specialized in the use of as a means of monitoring biological electron transfer processes coupled to enzymatic chemistry and long- range, extra-cellular ET. My work has spanned the problems of redox reactivity and mechanistic chemistry of enzymes, redox regulation and lability of novel [Fe2S2] proteins, and the mechanisms of extra-cellular ET in Shewanella. I have demonstrated the use of protein electrochemistry as a means to probe drug binding at redox proteins, and developing new electrochemical techniques for examining protein-protein interactions. Education 1990-1994 B.A. in Chemistry and English Amherst College summa cum laude, Phi Beta Kappa

1993 Bioinorganic Chemistry University of East Anglia Study Abroad, Norwich, UK

1994-2000 Ph.D. Bioinorganic Chemistry Caltech Division of Chemistry and Chemical Engineering Pasadena, CA Thesis Advisor: Professor Sunney I. Chan 2000 – 2002 EMBO Post-doctoral Fellow University of Oxford Laboratory Oxford, UK Advisor: Professor Fraser Armstrong, F.R.S. Academic Experience 2002 – 2008 Assistant Professor Boston University Dept. of Chemistry Molecular , Biology & Program 2008 – present Associate Professor with tenure Boston University Dept. of Chemistry, , & Biochemistry Program Fall 2011 Visiting Associate with Prof. Anthony Sinskey MIT Department of Biology Cambridge, MA Spring 2012 Visiting Associate with Prof. Dianne Newman Caltech Division of Biology Pasadena, CA

Sean J. Elliott! Curriculum vitae !Page 1 Honors and Awards 2011, 2013 Research Corporation for Science Collaborative Innovation Awardee 2010 Research Corporation Scialog Awardee 2008 Templeton Award for Excellence in Advising, Boston University 2007 Gitner Award for Distinguished Teaching, Boston University 2006 NSF CAREER Award 2005 – 2007 Smith Family Young Investigator Award 2000 – 2002 EMBO Long-term Postdoctoral Fellow 1997 – 2000 National Research Service Award (NIH) 1998 – 1999 Forris Jewett Moore Fellowship 1994 Doughty Award for Chemistry 1994 Phi Beta Kappa

Student Honors Resulting from Laboratory Research ! 2014 Stephanie Maiocco, Selected Attendee for New England American Chemical Society (NESACS) - German Chemical Society (GDCh) Exchange, Jena, Germany ! 2013 Evan T. Judd, Selected Oral Presentation, National Meeting of the Biophysical Society, Philadelphia, PA Evan T. Judd, Selected Oral Presentation, Graduate Research Seminar (GRC) in Bioinorganic Chemistry, Ventura, CA 2012 Stephanie Maiocco, Best Poster Award, Women in Chemistry Symposium @ Harvard University, Cambridge, MA Daniel W. Bak, Selected Oral Presentation, Workshop in Bioinorganic Chemistry at the Pennsylvania State University, State College, PA 2011 Kathryn D. Bewley and Katie Ellis, Selected Attendees for New England American Chemical Society (NESACS) - German Chemical Society (GDCh) Exchange, Erlangen, Germany Katie Ellis, Selected Oral Presentation, Graduate Research Seminar (GRC) in Bioinorganic Chemistry, Ventura, CA 2010 Mackenzie Firer-Sherwood, Selected Oral Presentation, Graduate Research Seminar (GRC) in Bioinorganic Chemistry, Ventura, CA 2006 Sarah Chobot (BU Undergrad) attendee for New England American Chemical Society (NESACS) - German Chemical Society (GDCh) Exchange, Humbolt, Germany

Sean J. Elliott! Curriculum vitae !Page 2 Publications (undergraduate authors noted with an asterisk) From Post-Tenure Period @ BU 44. Bak DW and Elliott SJ. “Alternative FeS cluster : tuning redox potentials and chemistry,” Current Opinions in , 2014, 19: 50-58. http:// dx.doi.org/10.1016/j.cbpa.2013.12.015 43. Duncan GGM, Marritt SJ, Firer-Sherwood MA, Shi L, Richardson DJ, Evans SD, Elliott SJ, Butt JN, Jeuken LJC. “Protein-Protein Interaction Regulates the Direction of and Electron Transfer in a Redox Enzyme Complex,” J. Am. Chem. Soc., 2013,135(28): 10550-6 . dx.doi.org/10.1021/ja405072z 42. Bak DW and Elliott SJ, “Conserved bond networks tune FeS cluster binding and structural stability,” Biochemistry, 2013, 52(27): 4687-4696. dx.doi.org/10.1021/bi400540m 41. Bewley KD, Ellis KE, Firer-Sherwood MA, Elliott SJ. “Multi-heme proteins: Nature’s electronic multi-purpose tool,” Biochimica et Biophysica Acta – Bioenergetics, 2013, 1827: (8-9), 938-948. dx.doi.org/10.1016/j.bbabio.2013.03.010 40. Judd ET, Youngblut M, Pacecho AA, Elliott SJ. “Direct electrochemistry of Shewanella oneidensis c nitrite reductase: evidence for interactions across the dimeric interface,” Biochemistry, 2012, 51(51): 10175-85. dx.doi.org/10.1021/bi3011708 39. Ellis KE, Frato KE, Elliott SJ. “Impact of Quarternary Structure upon Bacterial Cytochrome c : does homodimerization matter?” Biochemistry, 2012, 51(50): 10008-16. dx.doi.org/10.1021/bi301150n 38. Hamill MJ, Jost M, Wong C, Bene NC*, Drennan CL, Elliott SJ. “Electrochemical characterization of Escherichia coli adaptive response protein AidB”, International Journal of Molecular Sciences, 2012, 13(12), 16899-16915. dx.doi.org/10.3390/ijms131216899 37. Bewley KD, Firer-Sherwood MA, Mock JY*, Ando N, Drennan CL, Elliott SJ. “Mind the gap: diversity and reactivity of multiheme cytochromes of the MtrA/DmsE family,” Transactions of the Biochemical Society, 2012, 40(6), 1268-1273. dx.doi.org/10.1042/ BST20120106 36. Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. “Unusual Role for a Mobile Flavin in a StaC-like Indolocarbazole Biosynthetic Enzyme,” Chemistry & Biology, 2012, 19(7), 855-865. dx.doi.org/10.1016/j.chembiol.2012.05.016 35. Seidel J, Hoffmann M, Ellis KE, Seidel A, Spatzal T, Gerhardt S, Elliott SJ, Einsle O. “MacA is a Second Cytochrome c Peroxidase of Geobacter sulfurreducens”, Biochemistry, 2012, 50(21), 4513-20. dx.doi.org/10.1021/bi300249u 34. Youngblut M, Judd EJ, Srajer V, Sayyed B, Groelzer T, Elliott SJ, Schmidt M, Pacheco AA. “Laue crystal structure of Shewanella oneidensis cytochrome c nitrite reductase from a high- yield expression system”, Journal of Biological Inorganic Chemistry, 2012, 17(4), 674-662. dx.doi.org/10.1007/s00775-012-0885-0 33. Pulcu GS, Frato KE, Gupta R, Hsu H-R,* Levin GA,* Hendrich MP, Elliott SJ. “The Cytochrome c Peroxidase from Shewanella oneidensis Requires Reductive Activation”, Biochemistry, 2012, 50(5) 974-985. dx.doi.org/10.1021/bi201135s 32. Hamill MJ, Jost M, Wong CY, Elliott SJ, Drennan CL. “Flavin Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB “, Biochemistry, 2011, 49(46), 10159-10169. dx.doi.org/10.1021/bi201340t

Sean J. Elliott! Curriculum vitae !Page 3 31. Levin BD, Can M, Bren KL, Elliott SJ. “Methionine Lability in Bacterial Monoheme Cytochromes c: an electrochemical study”, Journal of – B, 2011, 11718-11726. dx.doi.org/10.1021/jp203292h 30. Firer-Sherwood MA, Ando N, Drennan CL, Elliott SJ. “Solution-based Structural Analysis of the Decaheme Cytochrome, MtrA, by Small Angle X-Ray Scattering and Analytical Ultracentrifugation,” Journal of Physical Chemistry – B, 2011, 11208-11214. dx.doi.org/ 10.1021/jp203603r 29. Ellis KE, Seidel J, Einsle O, Elliott SJ. “Geobacter sulfurreducens Cytochrome c Peroxidases: electrochemical classification of catalytic mechanisms, Biochemistry, 2011, 4513-4520. dx.doi.org/10.1021/bi200399h 28. Firer-Sherwood MA, Bewley KD, Mock JY*, Elliott SJ. “ Tools for Resolving Complexity in the Electron Transfer Networks of Multiheme Cytochromes,” Metallomics 3, 2011, 344-348. dx.doi.org/10.1039/C0MT00097C 27. Cong H, Becker CF, Elliott SJ, Grinstaff MW, Porco JA. “Silver Nanoparticle-catalyzed Diels-Alder Cycloadditions of 2’-Hydroxychalcones,” J. Am. Chem. Soc., 2010, 7514-7518. dx.doi.org/10.1021/ja102482b 26. Bak DW, Zuris J, Paddock M, Jennings PA, Elliott SJ. “Redox Characterization of the FeS Protein MitoNEET and Impact of Thiazolidinedione Drug Binding”, Biochemistry, 48, 2009, 10193-95. dx.doi.org/10.1021/bi9016445 25. Becker CF, Watmough NJ, Elliott SJ. “Electrochemical Evidence for Multiple Peroxidatic Heme States of the Diheme Cytochrome c Peroxidase of Pseudomonas aeruginosa”, Biochemistry, 48(1), 2009, 87-95. dx.doi.org/10.1021/bi9016445 24. Mitra S and Elliott SJ. “Oxidative disassembly of the [2Fe-2S] Cluster of human Grx2 and Redox Regulation in the Mitochondria,” Biochemistry, 48, 2009, 3813-15. dx.doi.org/ 10.1021/bi900112m 23. Hamill MJ, Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. “Direct electrochemical analyses of a thermophilic thioredoxin reductase: interplay between conformational change and redox chemistry”, Biochemistry, 47(37), 2008, 9738-46. dx.doi.org/10.1021/bi800676g 22. Hernandez HH, Jaquez OA, Hamill MJ, Elliott SJ, Drennan CL. “Thioredoxin reductase from Thermoplasma acidophilum: a new twist on redox regulation.” Biochemistry, 47(37), 2008, 9728-37. dx.doi.org/10.1021/bi8006753 21. Firer-Sherwood MA, Pulcu GS, Elliott SJ. “Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window”, J. Biol. Inorg. Chem., 13(6), 2008, 849-54. dx.doi.org/10.1007/s00775-008-0398-z 20.Ye T, Kaur R, Senguen FT, Michel LV, Bren KL, Elliott SJ. “Methionine Lability of Type I Cytochromes c: detection of ligand loss using protein film voltammetry,” J. Am. Chem. Soc., 130(21), 2008, 6682-83. dx.doi.org/10.1021/ja801071n 19. Michel LR, Ye T, Levin BD, Hahn MA, Russell BS, Elliott SJ, Bren KL. “The Role of Heme Pocket Mobility in Tuning Cytochrome c Redox Potential”, Biochemistry, 46, 2007, 11753-11760. dx.doi.org/10.1021/bi701177j 18.Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. “Direct Electrochemical Characterization of Archaeal Thioredoxins,” Angewandte Chemie International Edition, 46 (22), 2007, 4145-4147. dx.doi.org/10.1002/ange.200604620

Sean J. Elliott! Curriculum vitae !Page 4 17. Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. “Crystallographic trapping in the rebecamycin biosynthetic enzyme RebC,” Proc. Nat. Acad. Sci. U.S.A., 104, 2007, 15311-15316. dx.doi.org/10.1073/pnas.0707190104 From Pre-Tenure Period @ BU 16. Pulcu GS, Elmore BL, Arciero DM, Hooper AB, Elliott SJ. “Direct Electrochemistry of Tetraheme Cytochrome c554 from Nitrosomonas europaea: Redox cooperativity and conformational gating”, Journal of the American Chemical Society,129 (7), 2007, 1838 – 1839. dx.doi.org/10.1021/ja065657k 15. Bradley AL, Arciero DM, Hooper AB, Elliott SJ. “Protonation and Inhibition of Cytochrome c Peroxidase from Nitrosomonas europaea,” Journal of Inorganic Biochemistry, 101(1), 2007, 1733 - 1739. dx.doi.org/10.1016/j.jinorgbio.2006.09.009 14. Tarasev M, Pinto A, Kim D*, Elliott SJ, Ballou DP. “The ‘Bridging’ Aspartate 178 in Phthalate Dioxygenase Facilitates Interactions between the Rieske Center and the (II)- Mononuclear Center”, Biochemistry, 45(34), 2006, 10208-10216. dx.doi.org/10.1021/ bi060219b 13. Ye T, Wen X, Kaur R, Bren KL, Elliott SJ. “The redox properties of wild-type and heme- binding loop mutants of bacterial cytochromes c measured by direct electrochemistry,” Inorganic Chemistry, 44(24), 2005, 8999 - 9006. dx.doi.org/10.1021/ic051003l 12. di Bernardo D, Thompson MJ, Gardner TS, Chobot SE*, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, Collins JJ. “Chemogenomic Profiling on a Genome-wide Scale Using Reverse-Engineered Gene Networks,” Nature-Biotechnology, 23(3), 2005, 377-383. dx.doi.org/10.1038/nbt1075 11. Bradley AL, Chobot SE*, Arciero DM, Hooper AB, Elliott SJ. “A Distinctive Electrocatalytic Response From the Cytochrome c Peroxidase of Nitrosomonas europaea,” Journal of Biological Chemistry, 297, 2004, 13297-13300. dx.doi.org/10.1074/ jbc.C400026200 10. Chen KHC, Chen CL, Tseng CF, Yu SSF, Ke SC, Lee JF, Nguyen HT, Elliott SJ, Alben JO, Chan SI. “The Clusters in the Particulate (pMMO) from Methylococcus capsulatus (Bath),” Journal of the Chinese Chemical Society, 51(5B), 2004, 1081-1089. 9. Elliott SJ, Hoke K, Palak M, Heffron K, Rothery RA, Weiner JA, Armstrong FA. “Voltammetric Studies of the Catalytic Mechanism of the Respiratory Nitrate Reductase from E. coli,” Biochemistry, 43 (3), 2004, 799-807. dx.doi.org/10.1021/bi035869j 8.Léger C, Elliott SJ, Hoke K, Jones AJ, Jeuken LJC, Armstrong FA. “Enzyme electrokinetics: Using Protein Film Voltammetry to Investigate Redox Enzymes and their Mechanisms,” Biochemistry, 42, 29, 2003, 8653-8662. dx.doi.org/10.1021/bi034789c From Post-doctoral Period @ Oxford 7. Elliott SJ, McElheny AE, Feng C, Enemark JH, Armstrong FA. “A study of Interdomain Electron Transfer with Sulfite ,” Journal of the American Chemical Society, 124, 39, 2002, 11612-11613. dx.doi.org/10.1021/ja027776f 6.Elliott SJ, Léger C, Pershad HR, Hirst J, Heffron K, Ginet N, Blasco F, Rothery RA, Weiner JH, Armstrong FA. “Detection and Interpretation of Redox Potential Optima in the Catalytic Activity of Enzymes,” BBA-Bioenergetics, 1555(1-3), 2002, 54-59. dx.doi.org/10.1016/ S0005-2728(02)00254-2

Sean J. Elliott! Curriculum vitae !Page 5 From Graduate Student Period @ Caltech 5. Elliott SJ, Randall DW, Britt RD, Chan SI. “Pulsed EPR Studies of Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath): Evidence for Histidine Ligation,” Journal of the American Chemical Society, 120(13), 1998, 3247-3248. dx.doi.org/10.1021/ ja972968+ 4. Nguyen HHT, Elliott SJ, Yip JHK, Chan SI. “The Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath) is a Novel Copper-containing Three-subunit Enzyme – Isolation and Characterization,” Journal of Biological Chemistry, 273(14), 1998, 7957-7966. dx.doi.org/10.1074/jbc.273.14.7957 3. Elliott SJ, Zhu M, Tso L, Nguyen HHT, Yip JHK, Chan SI. “Regio- and Stereoselectivity of Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath),” Journal of the American Chemical Society, 119(42), 1997, 9949-9955. dx.doi.org/10.1021/ja971049g 2. Nguyen HHT, Nakagawa KH, Hedman B, Elliott SJ, Lidstrom ME, Hodgson KO, Chan SI. “X-ray Absorption and EPR Studies on the Copper Associated with the Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath). Cu(I) Ions and Their Implications,” Journal of the American Chemical Society, 118(50), 1996, 12766-12776. dx.doi.org/10.1021/ja961778g 1. Nguyen HHT, Zhu M, Elliott SJ, Nakagawa KH, Hedman B, Costello AM, Peeples TL, Wilkinson B, Morimoto H, Williams PG, Floss HG, Lidstrom ME, Hodgson KO, Chan SI. “The Biochemistry of the Particulate Methane Monooxygenase,” in Microbial Growth on C1 Compounds, Lidstrom M.E. and Tabita F.R. eds., 1996, p. 150-158.

Sean J. Elliott! Curriculum vitae !Page 6 Active Research Support 2013 - 2016 NSF CHE 1310012 Role: Principle Investigator “Connections Between Redox Chemistry and Catalysis in Multiheme Peroxidases” This grant investigates the structure-function relationship that governs the requirement for activation and conformational switching that occurs in diheme cytochrome c peroxidases. Protein electrochemistry and optical/magnetic are deployed to probe the sequence-based determinants of reactivity. 2011 - 2015 NSF MCB 1122977 Role: Principle Investigator “Redox Reactions of Thioredoxin Disulfide Bonds” This grant investigates the inter-connections between structure-function factors that tune the redox potentials of disulfide bonds in the thioredoxin superfamily, and the ability of -Cys-Xaa-Xaa-Cys- motifs to bind labile iron- clusters. 2011 - 2014 NIH F31GM099416 Role: Mentor for Evan Judd “Probing the Mechanism and Diversity of Sulfite Reductases” This training fellowship for Evan Judd investigates sulfite and nitrite reductase enzymes. The goal is to use a combination of protein electrochemistry and to probe the proton-coupled nature of key one- or two-electron linked steps associated with the catalytic mechanism.

2010 – 2014 Research Corporation Scialog Award Role: Principle Investigator “Transforming heme proteins into solar driven redox catalysts” This grant investigates the ability to tune the redox and porphyrin binding properties of multi-heme cytochrome c proteins that are used in Shewanella oneidensis for extra-cellular electron transfer. The goal of this work is use a chemical and synthetic biology approach to transform native Shewanella into light-stimulated machines charge transfer. 2013 - 2015 Research Corporation Collaborative Innovation Award Role: co-P.I “Photoinduced CO2 Reduction using Reverse TCA Enzymes” This grant investigates the ability to use nanoparticles coupled to reverse TCA cycle enzymes to achieve photo-induced CO2 reduction.

2014 - 2017 Arnold & Mabel Beckman Foundation, " Role: mentor “2014 Beckman Scholars Program", Thomas D Gilmore, PI.

Completed Research Support 2006 - 2012 NIH (NIGMS, R01-GM072663) Role: Principle Investigator “The Electrochemistry of Diheme Peroxidases”. $1,051,877 total costs.

2010 – 2013 Air Force Office of Scientific Research Role: co-Principle Investigator “Hybrid Metamaterials for Solar Biofuel Generation”. $183,000 total costs.

2006 - 2012 NSF (MCB 0546323) Role: Principle Investigator “CAREER: Redox Bioinorganic Chemistry and Protein-protein Interactions at an Electrode”. $839,958 total costs.

Sean J. Elliott! Curriculum vitae !Page 7 2005 - 2007 The Boston Foundation Role: Principle Investigator “Thioredoxin, thioredoxin reductase, and the molecular mechanisms of oxidative stress.” $350,000 total costs.

2005 - 2007 Petroleum Research Fund (#42428-G3) Role: Principle Investigator “Electrochemical studies of CueO, a multicopper oxidase.” $35,000 total costs.

Equipment and Training Grants 2013 NSF (CHE 1337811) Role: Major User “MRI: Acquisition of a MALDI TOF Mass Spectrometer”. $115,432 total costs.

2012 NSF (CHE 1136545) Role: Major User “MRI: Acquisition of a Circular Dichroism (CD) Spectrometer”. $101,175 total costs.

2010 NSF (CHE 0840418) Role: co-PI “Acquisition of an EPR spectrometer for Cyber-enabled Research and Education” $532,486 total costs.

2012 - 2015 NSF (CHE 1156666) Role: Participating mentor “REU Site: Fundamental Research in Chemistry Addressing Biological Problems” $300,000 total costs.

2011-present Beckman Foundation Role: Participating mentor “Beckman Scholars Program at Boston University”

Sean J. Elliott! Curriculum vitae !Page 8 Invited Presentations (international meetings are shown in bold) 2014: • Direct Electrochemistry of AdoMet Radical Enzymes, Iron-Sulfur Cluster Enzyme Gordon Research Conference. 2013: • The Electric: electrochemical studies of multiheme cytochromes c, Department of Chemistry, Johns Hopkins University, November 18; • The Metalloprotein Electric: electrochemical studies of multiheme cytochromes c, Department of Chemistry, University of Florida, March 15; • Tripping the Heme Fantastic: electrochemical studies of multiheme cytochromes c, Department of Chemistry, University of Washington, Seattle, March 19; • Mind the gap: long range ET across the periplasm in Shewanella, American Society of Biochemistry and Molecular Biology, oral presentation, April 21; • Tripping the Heme Fantastic: electrochemical studies of multiheme cytochromes c, Department of Chemistry, Georgia State University, May 6; • Tripping the Heme Fantastic: electrochemical studies of protein structure and function, Department of Chemistry & Biochemistry, University of California - Irvine, June 6; • Tripping the Heme Fantastic: electrochemical studies of multiheme cytochromes c Department of Chemistry & Biochemistry, University of California - San Diego, June 7 2012: •Tripping the heme fantastic: electrochemical studies of multiheme cytochromes c, Department of Chemistry, University of Michigan, September 27; • Discussion Leader, Microbial Basis for C1 Gordon Research Conference, August 5-9; • Heme-based molecular wiring: the Mtr cytochromes of Shewanella, Biochemical Society Meeting on Microbial: Interactions, Norwich, UK, April 2-5; • Moving the Electrons: applications of protein film voltammetry to heme protein structure and function, Department of Chemistry and Biochemistry, Cal State University – Northridge, February 22nd 2011: • Moving Electrons: studies of protein dynamics and catalysis, Department of Chemistry, Penn State University, September 8; • Thrice Upon a Heme: redox reactions of bacterial cytochrome c peroxidases, Enzyme Mechanisms Conference, St. Pete’s Beach, FL. January 5, 2011; • Moving Electrons: studies of protein dynamics and catalysis, Department of Chemistry, Massachusetts Institute of Technology, February 28; • Moving Electrons: studies of multiheme cytochromes c Canadian Biological Inorganic Chemistry (CanBIC) Conference, May 31, 2011 2010 • A Closed Case? Bacterial diheme peroxidases, Department of Chemistry, RPI, February 23; • Multi-heme Cytochromes c: One of Nature’s Solutions to Biological Charge Transfer. MIT Microbial Systems and Beyond Seminar Series, March 17; • Bacterial cytochrome c peroxidases: an open or closed case?, Canadian Chemical Society, June 2; • Bacterial Cytochromes c and Conformational Change, International Electrochemical Society Meeting, Nice, France, Sept 26-30; • Cytochromes c as solar sensitizers, Scialog Meeting, Tucson, AZ, October 14,2010; • Moving Electrons: using PFV to understand metallobiochemistry, Asian Biological Inorganic Chemistry Conference, Kaoshiung, Taiwan, 3 November;

Sean J. Elliott! Curriculum vitae !Page 9 • Thrice Upon a Heme: redox reactions of bacterial cytochrome c peroxidases, Khaoshiung Medical College, Tawain, 2 November; • Moving Electrons: using PFV to understand metallobiochemistry, Wyss Institute, Harvard University, November 10 2009 : • Department of Chemistry, Dartmouth College, May 15; • Department of Biochemistry and Chemistry, Arizona State University, March 20; • Department of Chemistry, UMass-Amherst, Feb 20 2008: • Two Faces of Sulfur Redox Chemistry, in Biology, Gordon Research Conference, Jan 30; • Two Faces of Sulfur Redox Chemistry Utah State University, Feb 27 2007: • When one heme is not enough: redox enzymology of multiheme proteins, Division of Chemistry, Caltech, May 17; • Misfires and Hardwires – the redox chemistry of oxidative stress enzymes. Department of Biochemistry and Molecular Biophysics, UPenn, April 11; • When one heme is not enough: redox enzymology of multiheme proteins. Deparment of Chemistry and Biochemistry, University of Maryland, March 1 2006: • Redox Enzymology of Multiheme Cytochromes: when one heme is not enough. Yale University, Department of Chemistry, October 2; • Voltammetric Tales: using electrochemistry to learn about enzymes; University of Michigan, Department of Biological Chemistry, October 10; • Voltammetric Tales: using electrochemistry to learn about enzymes; Montana State University, Department of Chemistry and Biochemistry, October 19; • Behind the Voltammograms: using electrochemistry to learn about enzymes, University of Montana, Department of Chemistry, October 16, 2006; • Voltammetric studies of proteins and enzymes: from redox cooperativity to enzymatic mechanism, University of Wisconsin, Department of Chemistry, October 23; • Redox Enzymology of Multiheme Cytochromes: when one heme is not enough, University of Minnesota, Department of Chemistry, October 25; • Voltammetric Tales: using electrochemistry to learn about enzymes, Duke University, Department of Chemistry, November 14; • University of North Carolina, Department of Chemistry, November 15; • University of Rochester, Department of Chemistry, November 20; • University of Illinois, Department of Chemistry, December 5; • Electrochemical Enzymology: Probing Dynamics and Mechanism at an Electrode. Frontiers in Metallobiochemistry Symposium in Molecular Biology, The Pennsylvania State University, June 10; • Probing the Flow of Redox Equivalents in Biological Mn Redox Cycling, Environmental Bioinorganic Chemistry Gordon Conference, June; • When one heme is not enough, Department of Chemistry, University of Iowa, April; • Direct Electrochemistry of Redox Active Flavoproteins. University of Texas Health Science Center – San Antonio, April 2005: • Direct Electrochemistry of Redox Active Proteins. Department of Chemistry, UMass- Dartmouth, November 2005;

Sean J. Elliott! Curriculum vitae !Page 10 • Electrochemical Studies of Heme Enzymes and Proteins, 12th International Conference of Biological Inorganic Chemistry, Ann Arbor, MI, August 3; • Redox Metallobiochemistry at an Electrode, Michigan State University, Inorganic Chemistry Seminar, April 18; • Redox Metallobiochemistry at an Electrode, UMass-Boston, April 13; • Redox biochemistry at an Electrode, 18th Enzyme Mechanisms Meeting, Asilomar, CA, January 7 2004: •Microbial Metallomics: A Bioinorganic Perspective, American Geophysical Union, Fall Meeting, December; • Investigating Redox Biochemistry at an Electrode, Redox Signaling in Biology and Disease, ASBMB Special Symposium, October; • Electrochemical characterization of a bacterial peroxidase, Electron Donors and Acceptor Interactions Gordon Conference, August; •Adventures in Protein Electrochemistry, Third German-American Symposium, Frontiers in Chemistry, July. 2003: • Interplay between redox species and biological systems, NESACS Undergraduate Day, November; •Research Experiences and Graduate Life at BU, Ithaca Colllege, 2003; • Moving electrons through Enzymes, Tufts University, Department of Chemistry; • Moving electrons into proteins, Amherst College, Department of Chemistry, 2002 : • Toxic Transition Metals and the Organisms that Love Them, BU seminar series, January, 2002.

Sean J. Elliott! Curriculum vitae !Page 11 Student Mentoring Fourteen Ph.D. students, in total Tao Ye, Ph.D., 2008 Immediately after graduating: Postdoctoral Scholar with Jianmin Gao at Boston College (2008-2010) Current: Abbvie Pharmaceuticals, Worcester, MA Gökçe Su Pulcu, Ph.D., 2010 Immediately after graduating: Marie Curie International Postdoctoral Fellowship at the University of Oxford with Prof. Hagen Bayley (ongoing) Michael J. Hamill, Ph.D., 2010 Immediately after graduating: Virdante Pharmaceuticals Currently: Scientist at Pronutria, Cambridge, MA Clinton Becker, Ph.D., 2011 Immediately after graduating: Postdoctoral Scholar with Matthew Poy at the Max- Delbrück-Center for Molecular , Berlin, Germany Currently: Scientist at Bayer, San Francisco, CA Mackenzie Firer-Sherwood, Ph.D., 2011 Immediately after graduating: Postdoctoral Scholar with John Golbeck (PSU) and Kenneth Nealson at University of Southern California Currently: Scientist at Baxter International, Los Angeles, CA Kathryn Bewley, Ph.D., 2012 Immediately after graduating: Postdoctoral Scholar with Sue Miller at University of California, San Francisco, San Francisco, CA (ongoing) Katie Ellis, Ph.D., 2012 Immediately after graduating: Pharm.D. program at UMass, Worcester, MA (ongoing) Benjamin D. Levin, Ph.D., 2013 Immediately after graduating: Postdoctoral Scholar with Ekaterina Pletneva at Dartmouth College, Hanover, NH (ongoing) Daniel W. Bak, Ph.D. (MCBB Program), 2013 Immediately after graduating: Postdoctoral Scholar with Eranthie Weerapana at Boston College, Chestnut Hill, MA (ongoing) Evan Judd, 2009 - Present, Current Student (MCBB program) Stephanie Maiocco, 2009 - Present, Current Student (Chemistry) Leon Li, 2011 - Present, Current Student (Chemistry) Kimberly Rizzolo, 2012 - Present, Current Student (Chemistry) Kristal Sullivan, 2012 - Present, Current Student (Chemistry)

M.A. Students: Phillipp Anwer (Chemistry) & Abigail E. Gay (Chemistry)

Undergraduates: Research Mentor for 21 BU undergraduate Chemistry or Biochemistry/ Molecular Biology Cocentrators, 2 BU REU students, 1 BU SURF student, and 1 BU PROSTARS student: Sarah (Chobot) Hokanson, Hao-Ru Jessie Hsu, Connie Wu, Victoria Polimeni, Justin Tackney, Laura Wong, Rachel Beard, Uyen Nhi Le, Olivia Grebler, Katherine Shinopolous, Duke Kim, Jessica Davison, Jee Yung Amanda Mock, George Levine, Eddie Barbieri (BU REU), Ernesto Casillas (SURF), Dominique Jaegger

Sean J. Elliott! Curriculum vitae !Page 12 (PROSTARS), Jane Weeks, Jane Fomina, Joshua Cole, Rishi Kulkarni, Anna Guzikowski, Stephanie Shternberg, Natalie Jones, Jonas de Oliveria (BU REU)

Postdoctoral Mentoring Three Postdoctoral Scholars Katie E. Frato, Ph.D., Postdoctoral Associate 2010-2013 Current: Assistant Professor Seattle University Sangha Mitra, Ph.D., Postdoctoral Associate 2007-2009 Current: MBA Program, Boston University Amy L. Bradley, Ph.D., Postdoctoral Associate 2002-2004 Current: Associate Professor of Chemistry, Wilkes-Barre University

University, College and Departmental Service 2013 - present Director of Graduate Studies, Department of Chemistry Manage academic affairs of ~100 graduate students Manage and supervise graduate curriculum Supervise Cume Exams Coordinate graduate student professional mentoring Attend academic ceremonies Coordinate student awards 2013 Panel member on “Being an Assistant Professor” 2013 – present Member of Chair’s Advisory Committee 1: academic programs 2013 – present Chemical Biology Faculty Search Committee (CHE) 2013 – present Member, Graduate Academic Affairs Committee of GRS 2003 – present Member of Molecular and Cellular Biology and Biochemistry (MCBB) Program Board, Boston University 2005 – present Member of the Biochemistry and Molecular Biology Program Board 2004 – present Member of Pre-Medical Advisory Board 2012 – 2013 Chemical Biology Faculty Search Committee 2010 – 2011 Experimental Physical Chemistry Faculty Search Committee 2009 – 2010 Biological Chemistry Search Committee, Chair (result: hiring Prof. Debbie Perlstein) 2009 – 2010 Graduate Affairs Committee 2009 – 2012 Post-doctoral Faculty Fellow Committee 2008 – 2012 Chemical Instrumentation Committee 2005 – 2012 Member of Chair’s Advisory Committee 2: faculty actions 2006 – 2011 Member, Undergraduate Research Opportunities (UROP) Advisory Committee 2002 – 2012 Graduate Admissions Committee, Department of Chemistry 2004 – 2006 Faculty Facilitator in Responsible Conduct in Research program, directed by the Provost’s Office 2006 – 2007 Participant in Undergraduate Admissions Office Recruiting 2007 Panel member, Multicultural Weekend for Undergraduate Recruiting 2005 Discussion Leader in Center of Excellence in Teaching workshop, “Mentoring Undergraduates in Research”

Sean J. Elliott! Curriculum vitae !Page 13 2005 – 2006 Biochemistry Search Committee (result: hiring Prof. Adrian Whitty) 2005 – 2006 Inorganic Search Committee (result: hiring Prof. Linda Doerrer) 2005 – 2006 Departmental Space Committee 2004 – 2005 Biochemistry Search Committee (result: hiring Prof. Pinghua Liu) 2002 – 2011 Colloquium Committee

Extramural Service 2012 Lecturer and Instructor in Laboratory Practical for Electrochemistry, Penn State University Workshop in Bioinorganic Chemistry 2012 Reviewer for Research Council (UK) grant applications 2012 Reviewer for Portuguese Foundation for Science and Engineering (FCT) grant applications 2012 External Examiner, Royal Holloway, University of London, UK 2012 Panel member, DOE Review Panel, Energy Frontier Research Centers 2011 ad hoc member of NIH MSF-A study section 2011 Facilitator, Gordon Research Conference/Graduate Research Seminar in Metallobiochemistry, Ventura, CA 2004-present Board member of the Boston Regional Inorganic 2002-present Reviewer for Journal of the American Chemical Society, Biochemistry, Nature Structural Biology, Inorganic Chemistry, Journal of Biological Inorganic Chemistry, and Biochemical Journal. 2006-present Ad hoc reviewer for National Science Foundation proposals. 2006-2007 Moderator, Boston Regional Department of Energy SciBowl competition for high-school students

Teaching Experience 1. Developed 6 experimental modules for teaching the practical aspects of protein electrochemistry, to be used at the recurring Penn State Workshop in Bioinorganic Chemistry, for graduate students, post-doctoral scholars and undergraduates 2. Taught CH109, General and Quantitative for undergraduates at Boston University. Fall 2007, 2009, 2010, 2012 3. Taught CH110, General and Quantitative Analytical Chemistry for undergraduates at Boston University. Spring 2004-2007 4. CH 633, Physical Methods for Inorganic Chemistry, a course for graduate students and advanced undergraduates at Boston University. Fall 2003, 2005, 2007, 2012 5. Participated in the development and teaching of CH 801/802, Graduate Research Methods and Writing, a new course for graduate student training within the Chemistry Department of Boston University. Fall 2003-2007. Taught course exclusively in 2013. 6. Developed and taught, CH634, Metallobiochemistry for graduate students at Boston University. Fall 2002, 2004, 2006, Spring 2008, Fall 2010 and 2013. 7. First year tutor in Biological Chemistry for Chemistry Students at St. John’s College, St. Catherine’s College and Christchurch College, University of Oxford. 8. Head Teaching Assistant for Prof. Sunney I. Chan and Prof. Stephen Mayo’s Physical Chemistry for the Biological Sciences (1998-1999) at the California Institute of Technology.

Sean J. Elliott! Curriculum vitae !Page 14