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CHEM 5339.001 Bioinorganic Chemistry THE UNIVERSITY OF CHEM 5339.001 TEXAS AT TYLER FALL 2020 Bioinorganic Chemistry Dr. Jason Smee Contact Info Course Description [email protected] Study of the role metal ions play in the structure and funcon of nucleic acids, pro- 903.566.7069 teins, and metalloenzymes. Topics include bio-coordinaon chemistry, modeling studies, and experimental techniques, as well as aspects of medicinal inorganic RBS 3030 chemistry. Office Hours Bioinorganic (adjective): of, relating to, or concerned with the application of inorganic chemistry and its MF 10:30−noon techniques (as nuclear magnetic resonance) to the study of biological processes and substances (as TR 1:30−2:30 pm metalloproteins) in which inorganic substances are important constituents or play important roles or by appointment - Merriam-Webster dictionary Image taken from hp://guweb2.gonzaga.edu/faculty/ cronk/CHEM245pub/myoglobin.html Inside the Syllabus Required & Recommended Materials The required text is Bioinorganic A scienfic calculator Other Useful Re- 2 Chemistry ‐‐ Inorganic Elements (capable of exponents sources in the Chemistry of Life: An Intro‐ and logarithms) is re- Student Learning ducon and Guide, 2/e by Kaim, quired. 2 et al. (ISBN 978-1-118-13807- Outcomes (Image from hps:// 6978-0-470-97523-7) www.schoolspecialty.com/ casio-scienfic-calculator- (Image from hps://www.wiley.com.) Canvas 2 035399.) Course 3 Requirements A portable device with a webcam is required for parcipang in Zoom lectures. If circumstances dic- tate that we go online before Thanksgiving, we will have online lectures and we will do oral presenta- In-Class Presenta- ons using Zoom. Please install the Zoom soware on your device (hps://zoom.us/download). 3 tion Important Covid-19 Information for Classrooms and Laboratories Final Project 3 Students are required to wear face masks covering their nose and mouth, and follow social distancing guidelines, at all mes in public sengs (including classrooms and laboratories), as specified by Procedures for Fall 2020 Return to Normal Operaons. The UT Tyler community of Patriots views adopon of these pracces consistent Homework 4 with its Honor Code and a sign of good cizenship and respecul care of fellow classmates, faculty, and staff. Students who are feeling ill or experiencing symptoms such as sneezing, coughing, or a higher than normal tem- Exams 4 perature will be excused from class and should stay at home and may join the class remotely. Students who have difficulty adhering to the Covid-19 safety policies for health reasons are also encouraged to join the class re- motely. Students needing addional accommodaons may contact the Office of Student Accessibility and Re- Grading 4 sources at University Center 3150, or call (903) 566-7079 or email saroffi[email protected]. Important Dates 4 Recording of Class Sessions Class sessions may be recorded by the instructor for use by students enrolled in this course. Recordings that contain personally idenfiable informaon or other informaon subject to FERPA shall not be shared with indi- Topics Covered 5 viduals not enrolled in this course unless appropriate consent is obtained from all relevant students. Class re- cordings are reserved only for the use of students enrolled in the course and only for educaonal purposes. Course recordings should not be shared outside of the course in any form without express permission. University Policies 5-7 Page 2 CHEM 5339.001 Bioinorganic Chemistry Other Useful References Bioinorganic textbooks: Inorganic Chemistry 6/e by Shriver et al. 9781429299060; Bioinorganic Chemistry: A Short Course, 3/e by Roat-Malone 9781119535218; Princi‐ ples of Bioinorganic Chemistry by Lippard and Berg 9780935702736; Biological Inor‐ ganic Chemistry by Berni et al. 9781938787966 Medicinal inorganic textbooks: Metals in Medicine by Dabrowiak (9780470681961); Medicinal Inorganic Chemistry by Sessler (978-0195686982) Cobalamin, also known as Chem LibreTexts website: of parcular interest are the Bioinorganic book and the vitamin B12 (shown here “Spectroscopy” supplementary module to (Physical and Theorecal Chemistry as the cyano complex), was the first known bio- the UTT library website (library.uyler.edu) for the following class-related acvies. inorganic compound. It Need off-campus access? Go to Connecng from Off-Campus: Welcome page plays a significant role in many biological processes. Classic and current bioinorganic/medicinal inorganic arcles for discussion (Image from Wikipedia.) and homework A 15-minute oral presentaon on a current arcle related to this course A final project wring quiz/exam quesons for undergraduate inorganic stu- dents using excerpts from journal arcles related to this course Student Learning Outcomes By the end of this course, students should be able to Crystal structure of hu- 1) Interpret the results of different types of characterizaon techniques used in man ferredoxin-1. Ferre- bioinorganic studies doxins are one type of iron and sulfur-containing 2) Recognize the different roles played by metalloproteins and metalloenzymes proteins that involved in a wide variety of electron 3) Extract key concepts from classic and current journal arcles transfer processes. (Image 4) Effecvely present, in seminar format, a summary of the results of a journal from Wikipedia) arcle relang to bioinorganic or medicinal inorganic chemistry 5) Create quiz/exam quesons for undergraduate inorganic students using ex- cerpts of journal arcles Canvas I will ulize Canvas to post the following items 1) syllabus Electron paramagnetic/ 2) lecture notes spin resonance (EPR or ESR) is a form of spec- 3) Links to Zoom recordings of lectures troscopy similar to NMR, but instead of nuclei, it 4) grades (my Excel grade book has the official grades) looks at unpaired elec- trons. Interestingly, EPR/ You may be asked to submit porons of homework assignments through Can- ESR spectra are usually plotted as the first deriva- vas as well. Such assignments will ulize Turnin to minimize plagiarism. tive. (Image from Wikipe- dia.) CHEM 5339.001 Bioinorganic Chemistry Page 3 Course Requirements 1) One semester of undergraduate inorganic chemistry similar to CHEM 3320 and/or CHEM 4330 and one semester of undergraduate biochemistry are strongly suggested. 2) We meet Wednesdays from Aug 26 to Dec 2, except during Thanksgiving week (Nov 23—27). All classes will be online (Zoom) aer Thanksgiving break Active site of human man- (including final exams). Aendance will be taken and class parcipaon will ganese superoxide dis- be sought to nurture student communicaon and presentaon skills. mutase (SOD). SOD con- െ verts superoxide O2 into 3) You will be required to give a 15-minute presentaon over a journal arcle O2 and H2O2 and is one of several enzymes that deal obtained from such journals as Inorganic Chemistry, Journal of Biological In‐ with oxidative stress. organic Chemistry, and Journal of Inorganic Biochemistry. (Image from Wikipedia.) 4) You will also be required to write exam quesons suitable for undergraduate inorganic students using excerpts from journal arcles related to bioinorgan- ic or medicinal inorganic chemistry 5) The cumulave final exam (online) will be on Wednesday, December 9th from 7-9 pm and must be taken to pass the course. Mossbauer spectroscopy is a technique that relies In-Class Presentation upon the nearly recoil-less absorption of gamma rays Towards the end of the semester you will be asked to give a 10-15 minute presen- and is very sensitive to the taon summarizing the results of a recent (last 5 years) arcle or communicaon chemical environment of (i.e. a mini-arcle) relang to bioinorganic or medicinal inorganic chemistry. If you the sample. By far, the most commonly studied are unsure of whether a paper is suitable, please ask me. Good journals to look element is iron. (Image through are Journal of Biological Inorganic Chemistry (SBIC), Journal of Inorganic from Wikipedia.) Biochemistry (Elsevier), and Inorganic Chemistry (ACS); although there are others . The grade will be based primarily on organizaon, style, clarity, and the ability to answer quesons related to this course. A rubric will be provided to help with the planning of your presentaon. Final Project The final project is worth 10% of the course grade. Select 5 bioinorganic or medici- nal inorganic chemistry arcles. Then write 3 quesons for undergraduate inor- ganic students using an excerpted materials from each arcle (e.g. figure and table/graph). Topics include, but are not limited to, oxidaon states, naming, or- Crystal structure of octo- ders of reacons, HSAB theory, point groups, spectroscopy, trans effect, and topics pus hemocyanin. Hemocy- relevant to this course. More details, including my grading rubric, will be provided. anin is a O2 transport protein used by some Two mulple choice quesons per arcle maximum. invertebrates. The active You must idenfy what inorganic topic each queson covers. site consists of two cop- per(I) ions that, upon You must provide a rubric for grading any short answer/calculaon problems. binding O2, are oxidized to copper(II) resulting the You must provide a properly formaed (ACS style) citaon for each paper; blue (cyan) color. (Image providing an electronic copy is oponal. from Wikipedia.) Page 4 CHEM 5339.001 Bioinorganic Chemistry Homework Homework (25% of the course grade) is comprised of 1) problem sets; and 2) ques- ons regarding assigned reading of classic and current papers. Each assignment will be due at the beginning of the next class. Exams TM Auranofin (Ridaura ) is a 1) Two mid-term exams will be given during class me and are collecvely worth gold-phosphine thiolate complex that was a first- 30% of your overall grade. They will be a mixture of short answer/calculaon generation therapeutic quesons and mulple choice. I will inform you where the material will be cut- used in the treatment of off at least one week before the exam. The final exam is 25% of the grade. rheumatoid arthritis. (Image from Wikipedia.) 2) Missed exams due to an unexcused absence will result in a grade of zero.
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