ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VOLUME 27 * JUNE 1985 * NUMBER 6

Leon H. Schmidt, Edlitor in Chief (1985) Robert C. Moellering, Jr., Etlitor (1987) Unlivevr.sity of Alabana in Bi-inif'/igllam NVw' Etiglant Dco(t0iesS ILHoJspital Birmiiinghattn Bostoti, Ma.so(lahsetts Herbert L. Ennis, Editor (1987) Christine C. Sanders, Editor, (1989) Roche Institiute of AMole(ula(l Biology Creightoni Universitv Sc(0hoolfoV'(lidcil( Nmutlev, Newi, Jer-seyv Omaha, Nebraska Robert L. Hamill, Editor (1985) Peter G. Welling, Eklitor (1988) Eli Lil//, & Colfnpany l(c. Warl Clr-La/Ub/t Co. Indiaina(lpolis, lntdianlal A tin Arbor, Michigall George A. Jacoby, Jr., Elitor (1985) John A. Washington II, Editor (1986) Massachusetts Generatil Hospital Mayo Clinic Boston Rochester. NIilhlC 'vota

EDITORIAL BOARD Norris Allen (1986) Arthur English (1986) Joan Lusk (1986) Nlerle Sande (198>() Vincent T. Andriole (1987) Robert J. Fass (1985) R. Luthy (1986) NV. Eugene Sanders, Jr. (1987) Bascom F. Anthony (1985) Stuart Feldman (1985) Francis L. Macrina (1985) WV. NMichael Scheld (1986) George R. Aronoff (1986) Sydney Finegold (1985) Gerald L. Mandell (1986) Jerome J. Schentag (1985) Robert Austrian (1986) Robert J. Fitzgerald (1986) Garv R. Matzke (1986) Raymond F. Schinazi (1986) Richard H. Baltz (1987) Martin Forbes (1986) George H. McCracken (1987) Fritz D. Schoenknecht (1986) Rashmi H. Barbhaiya (1986) John N. Galgiani (1987) Antone A. Medeiros (1987) F. C. Sciavolino (1985) Arthur L. Barry (1986) Dale N. Gerding (1985) Gerald Medoff (1986) VW'illiam NI. Shannon (1986) John G. Bartlett (1987) Anthony J. Glazko (1987) NMichael Miller (1987) Charles Shipman, Jr. (1985) Michael Barza (1985) Irving H. Goldberg (1985) Barbara Minshew (1985) Robert NV. Sidwell (1987) William M. Bennett (1987) Jack Gwaltnev (1986) Thomas P. Moyer (1986) P. Frederick Sparling (1987) Richard F. Bergstrom (1985) Scott NI. Hammer (1986) Barbara E. Murrav (1987) Harold Standiford (1985) Karen K. Biron (1987) W. Lee Hand (1986) John D. Nelson (1986) I)avid A. Stevens (1986) Gerald P. Bodey (1986) H. Hunter Handsfield (1986) Harold C. Neu (1986) Stephen E. Straus (1987) Arthur E. Brown (1987) Joseph Hawkins, Jr. (1985) Lawrence A. Pachla (1987) R. Sutherland (1985) Lawrence E. Bryan (1985) Frederick G. Hayden (1987) Joseph S. Pagano (1987) Morton N. Swartz (1985) Ward Bullock (1987) Nlichael Higgins (1986) James 'T. Park (1985) Richard B. Sykes (1985) Tsun Chang (1986) David C. Hooper (1987) James E. Pennington (1986) Francis P. Tally (1987) Anthony Chow (1985) Richard Hornick (1986) T. J. Perun (1986) Alexander Tomasz (1985) C. Glenn Cobbs (1986) George Gee Jackson (1986) Lance R. Peterson (198X5) Ralph Tompsett (1985) Paul S. Cohen (1986) James H. Jorgensen (1987) Michael Rein (1986) Francis L. S. Tse (1986) William A. Craig (1987) William J. Jusko (1986) W. H. G. Richards (1986) Richard J1. Wallace, Jr. (1987) Naomi Datta (1987) A. W. Karchmer (1985) Richard Roberts (1985) Michael W'aring (1987) Lawrence E. Day (1986) Donald Kaye (1985) Ian M. Rollo (1985) Bernard XN'eisblum (1985) William E. Dismukes (1987) George S. Kobayashi (1985) Allan Ronald (1987) Richard NI. Welch (1986) R. Gordon Douglas, Jr. (1986) Donald J. Krogstad (1986) Richard Root (1986) Richard Wise (1986) John C. Drach (1987) Felix Leitner (1986) John P. Rosazza (1986) John S. Wolfson (1987) George L. Drusano (1987) Stephen A. Lerner (1986) Jon E. Rosenblatt (1985) Lowell Young (1985) Theodore Eickhoff (1985) Stuart B. Levv (1986) Robert H. Rubin (1987) Pauline K. WV. Yu (1985) Gertrude B. Elion (1987)

Helen R. Whiteley, Chairman,ti. Publication.s Board Walter G. Peter III, Director of Publications Linda M. Illig, Managing Editor, Jourtnals Deborah J. Shuman, Production Edit(or

Antimicrobial Agents antid Chemotherapy (ISSN 0066-4804). an interdisciplinary publication of the American Societs for Microbiology. 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial. antiparasitic. and anticancer agents and chemotherapy. Instructions to authors are published in the JamnuIary issue each year; reprints clre available fr-om the editors and the Publications Departmient. Antimicrobial A,cnts anditl CheMotherIaP is published monthly. and the twelve number-s are dividedc into two volumes per year. The nonmember suLbscription price is $157 per year: single copies are $21. The member subscription price is $31 (foreign, $41 [surface rate]) per year; single copies are $7. Correspondence relating to subsCIiptions, reprints, defective copies. illlability of back issues, lost or late proofs. disposition of submittedimanuscripts, and general editorial matters shouLld be directed to the ASM Publications Department. 1913 I St.. NW, Washington. DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States. Canada. and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claiims within 6 months of publication of the issues. Claims for issues missing becaLuse of failure to report an address change or for issuLes "missing from files" will not be allowed. Second-class postage paid at Washington. DC 20006. and at additional mailing offices. POSTMASTER: Send address changes to Antimicrobial Agentts antd( Chemnthorapv. ASM. 1913 1 St.. NW. Washington. D)C 20006. Made in the United States of America. Copyright L': 1985, American Society for Microbiology. E] )f VeK.ki,,-JXI, RI jt All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article mtlay be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier- pay the stated per-copy fee through the Copyright Clearance Ceniter, Inc.. 21 Congress St.. Salem, MI\A ((1970). for copying beyond that per-mitted by Sections 107 and 108 of the U.S. Copyright Law. This consent dloes not extend to other kinds of copying. sLuch as copying for- generll distributionl, for advertising or promotional purposes, for creating new collective works, or for- reslle. Author Index

Alving, Carl R., 903 Gavan, Thomas L., 982 Kuhrt, M. F., 883 Raymond, Gilles, 928 Attfield, P. V., 985 George, W. Lance, 966 Reinhardt, John F., 966 Ayers, Leona W., 982 Gerlach, E. Hugh, 982 Lawrence, Adam G., 964 Rill, Wayne L., 903 Gilbert, David N., 897 Leathers, Timothy, 892 Ryan, D. Michael, 925 Beale, Angela S., 980 Giles, Penelope, 953 Lemieux, Michel, 928 Bennett, William M., 897 Giovenella, Albert J., 961 Lessard, Celine, 928 San Joaquin, Venusto H., 908 Bergeron, Michel G., 928 Gorbach, Sherwood L., 968 Lindqvist, Lennart, 943 Shalit, Itamar, 908 Berman, Jonathan D., 916 Grappel, Sarah F., 961 Lin, Jung-Chung, 971 Skold, Ola, 933 Boon, Ronald J., 980 Greenberg, Stephen B., 953 Luman, J. Ileice, 912 Smith, M. Carolyn, 971 Brander, Pirkko, 948 Sommers, Herbert M., 982 Brochu, Gilles, 928 Hadley, W. Keith, 958 Madigan, Sanford, 974 Steele, Lorraine C., 912 Brooks, Dandrea L., 912 Hanson, Brian D., 916 Marks, Melvin I., 908 Steen, Rolf, 933 Harris, Deborah, 953 Martin, R. Russell, 953 Stevenson, Roselynn M. W., 938 Canonico, Peter G., 903 Holland, Susan, 989 Mayor, Gilbert, 897 Suzuki, Yasuhiko, 921 Houang, Elizabeth T., 964 McColm, Andrew A., 925 Swartz, Glenn M., Jr., 903 Dale, Jeremy W., 989 Houghton, Donald C., 897 McKinlay, M. A., 883 Sweet, Richard L., 958 Dandu, Vijay R., 977 McLarty, Jerry W., 912 Sypherd, Paul S., 892 De Grandis, Stephanie A., 938 Jackson, Andre J., 977 Mdtras, Jacques, 928 Desaulniers, Denis, 928 Jacobus, Nilda V., 968 Mordenti, Joyce, 887 Despres, Jean-Paul, 928 Jokipii, Anssi M. M., 948 Tally, Francis P., 968 Diana, G. D., 883 Jokipii, Liisa, 948 Nagata, Akihisa, 921 Tuner, Kajsa, 943 Dias, M. Beatriz Souza, 968 Jones, J., 966 Nisbet, Louis J., 961 Didolkar, Mukund S., 977 Jones, Ronald N., 982 Nord, Carl Erik, 943 Waddell, David, 916 English, Jan, 897 Ohm-Smith, Marilyn J., 958 Wallace, Richard J., Jr., 912, 953 Kasbekar, Durgadas P., 974 Ono, Yasuko, 921 Welch, David F., 908 Fancher, M. J., 883 Katz, Eugene, 974 Otto, M. J., 883 Wilson, Rebecca W., 912 Fiore, Dario, 977 Kende, Meir, 903 Fowlston, S., 966 Kohlhepp, Sue, 897 Pagano, Joseph S., 971 Yamada, Takeshi, 921 Fox, M. P., 883 Kohnen, Paul W., 897 Pinney, R. J., 985 Yamanouchi, Takahisa, 921 AUTHOR INDEX VOLUME 27

Aalen, Odd, 107 Bowman, Bernard U., Jr., 399, Dale, Jeremy W., 989 Fliegelman, Robert M., 429 Adams, M., 275 404, 408 Dandu, Vijay R., 977 Fontana, Roberta, 828 Aiba, Shuichi, 367 Box, Quellin T., 181 D'Aquino, Miguel, 137 Forrest, A., 605 Alexander, W. James, 760 Brajtburg, Janina, 172 Datema, Roelf, 753 Fowlston, S., 966 Allan, J. Davis, 782 Brammer, Keith W., 832 David, Hugo L., 701 Fox, Jack J., 733 Alpert, Martin L., 422 Brander, Pirkko, 948 Debbia, Eugenio, 615 Fox, M. P., 883 Alvarez, Salvador, 646 Brandis, Henning, 836 De Grandis, Stephanie A., 938 Frank, Karl B., 445 Alving, Carl R., 903 Brater, D. C., 436 DeHertogh, Deborah A., 670 Freij, Bishara J., 431 Ambinder, Richard F., 217 Brier, Michael E., 812 Delaha, Edward C., 485 Friedhoff, Lawrence T., 263 Anderson, R., 257 Brier, Richard A., 812 Delatour, Frederique, 520 Friedman-Kien, Alvin E., 763 Anwar, Hosmin, 220 Brion, Nils, 520, 660 Del Bene, Victor E., 817 Fuchs, Peter C., 679 Aoki, Fred Y., 753 Brochu, Gilles, 928 DeLong, Donald C., 102 Fujii, Tadashi, 608, 612 Aoyama, M., 595 Brooks, Dandrea L., 912 de Lorenzo, Victor, 666 Fujiwara, Tatsushi, 65 Apicella, Michael A., 16 Brown, Michael R. W., 220 de Miguel, Constantino, 76 Arao, Nakako, 565 Brummer, Elmer, 363 De Mol, Patrick, 388 Galask, Rudi, 337 Araujo, Fausto G., 491 Bruns, Wolfgang, 632 Desaulniers, Denis, 928 Gallion, Corinne, 503 Arizpe, H. M., 184 Bryan, Elza R., 102 Desjardins-Giasson, Suzanne, Garaci, E., 625 Arnold, Keith, 192 Buck, R. E., 207 720 Garagusi, Vincent F., 485 Aronoff, George R., 812 Bulkacz, Jaime, 427 Desjardins, Robert E., 525 Garaud, Jean-Jacques, 520 Attfield, P. V., 985 Bullock, Ward E., 291 Despres, Jean-Paul, 928 Garcia-Bustos, Jose F., 791 Ayers, Leona W., 982 Burkey, Linda J., 817 Deybach, Jean-Charles, 520 Garcia-Prats, Joseph A., 511 Ayers, Ouida M., 324 Burns, Jane L., 46 Dhruv, R., 263 Garcia-Riestra, Carlos, 114 Aznar, Javier, 76 Bush, Karen, 555 Diana, G. D., 883 Gauntt, C. J., 184 Butzler, Jean-Paul, 388 Dias, M. Beatriz Souza, 968 Gavan, Thomas L., 982 Bailey, Denis M., 4 Dickins, Cathy S., 332 Geary, Timothy G., 21 Baird, Anne, 858 Caballero, Maria C., 76 Didolkar, Mukund S., 977 Gebhart, Connie J., 55 Baker, Carol J., 511 Cafarell, Robert F., 16 DiPiro, Joseph T., 487 Gentry, Layne O., 683 Baker, Neil R., 468 Canonico, Peter G., 903 DiVincenzo, Cathy A., 712 George, W. Lance, 643, 966 Balber, Andrew E., 33 Carbon, Claude, 520, 660 Divo, Alan A., 21 Gerlach, E. Hugh, 413, 982 Baldwin, Jack N., 234 Carek, Peter J., 817 Dobson, Richard A., 4 Gerson, Benjamin, 357 Bansal, Madhu B., 640 C,rlson, Karin, 107 Donowitz, Gerald R., 125 Ghysels, Guido, 388 Barry, Arthur L., 679 Carter, Walker T., 876 Douce, Richard, 291 Gibson, Gene A., 745 Barry, David W., 167 Carter, W. T., 674 Douglas, John M., 203 Gilbert, Brian E., 309 Baucks, Regina, 632 Casal, Manuel J., 282 Dowling, John N., 272 Gilbert, David N., 897 Bawdon, R. E., 436 Cauchy, Michael J., 720 Drake, Thomas A., 320 Giles, Penelope, 953 Bawdon, Roger E., 874 Chaffin, Donald, 531 Dromer, Francoise, 660 Gillespie, Matthew T., 79 Bayoumi, Samir M., 487 Chamberlain, Paul D., 858 Drupa, Ilga, 11 Ginsberg, Bernard P., 422 Beale, Angela S., 980 Chambers, Henry F., 685 Drusano, G. L., 605 Giovenella, Albert J., 961 Beaubien, Arthur R., 720 Chan, Ying-Pui M., 192 Duff, Ronald G., 197 Goering, Richard V., 455 Bechard, Douglas L., 263 Chau, P. Y., 872 Duke, Arit E., 277 Gokhale, Rajeev, 487 Beck, C. F., 879 Cheng, Yuan Rong, 828 Dupont, Marie-Jeanne, 280 Goldstein, Ellie J. C., 162, 422, Bellora, Mauricio J. Gatto, 137 Cheng, Yung-Chi, 416, 445 Dure, Leon, 309 657 Benavente, Maria C., 282 Cheriyan, U. O., 184 Dzink, JoAnn L., 663 Goodman, Larry J., 429 Benes, Solomon, 724 Chiou, Jwo-Farn, 416 Goossens, Herman, 388 Bennett, William M., 897 Chisholm, D. R., 207 Edwards, Morven S., 511 Gootz, Thomas D., 739 Benziger, David P., 769, 774 Chonmaitree, Tasnee, 181 Elberg, Svetlana, 172 Gorbach, Sherwood L., 968 Berens, Randolph L., 33 Chow, Anthony W., 749 Eliopoulos, George M., 357, 782 Gorbea, Hector F., 570 Bergeron, Michel G., 928 Christenson, Bernard, 570 Eliopoulos, G. M., 28 Gordin, Fred M., 452, 648 Berk, Steven L., 646 Citron, Diane M., 162, 657 Ellis, M. Nixon, 167 Gordon, Kathryn P., 37 Berman, Jonathan D., 916 Clavier, Francoise, 561 Ellner, Jerrold J., 413 Gordon, Kathy P., 739 Bertram, Miriam A., 515 Cohenford, Menashi, 479, 715 Emmerman, J., 424 Gottlieb, Alan, 270 Bettex, Jean-David, 350, 353 Coignau, Hugo, 388 English, Jan, 897 Grados, Oscar, 388 Bibler, Mark, 291 Colby, Steven D., 71 Eng, Robert H. K., 688 Grappel, Sarah F., 961 Bies, M., 207 Congeni, Blaise L., 181 Ericson, Ann-Christin, 753 Greenberg, Stephen B., 953 Bint, Adrian J., 508 Contrepois, Alain, 520, 660 Exeiby, Alice, 102 Gremillion, David H., 868 Birk, R. J., 424 Cook, James L., 11 Griffin, Karen E., 495 Bistoni, F., 625 Cooksey, Robert C., 234 Fairgrieve, John S., 197 Grimont, Patrick A. D., 806 Blaser, Jurg, 343 Coombes, James D., 535 Fancher, M. J., 883 Grossgarten, Michaela, 836 Blayo, Marie-Claude, 561 Corey, Lawrence, 203 Fanucchi, Michael P., 733 Gruber, William C., 511 Blumer, Jeffrey L., 583 Cornett, James B., 4 Faurisson, Francois, 520 Guarderas, Juan, 646 Bode, Robert, 291 Costerton, J. W., 619 Feinberg, Aaron, 733 Guibert, Jacqueline, 177 Bodey, Gerald P., 265 Couch, Robert B., 309 Fenwick, Raymond G., 460 Gurney, Michael, 652 Boere, Wil A. M., 802 Couetdic, Gerard, 280 Ferraro, Mary Jane, 782 Gurusiddaiah, S., 239 Bonner, Daniel P., 555 Cramer, William A., 836 Finegold, S. M., 674 Boon, R. J., 495 Craven, Philip C., 868 Finegold, Sydney M., 876 Hackbarth, Corinne J., 135, 224, Boon, Ronald J., 980 Crawmer, Bruce P., 769 Fiore, Dario, 977 320, 340, 452, 685 Boozer, Richard M., 42 Creger, Richard J., 413 Fisher, Melanie A., 745 Hadley, W. Keith, 958 Borner, Klaus, 375 Crider, Steven R., 71 Fish, R. G., 275 Hamilton, Bruce, 291 Boscia, Jerorne A., 708 Critchlow, Cathy, 203 Fish, Wallace R., 33 Hancock, Counce, 733 Bowdre, Jean H., 525 Crooke, Stanley T., 460 Flepp, Markus, 350, 353 Hand, W. Lee, 42 i ii AUTHORINDEX ANTIMICROB. AGENTS CHEMOTHER.

Hanson, Brian D., 916 Kelley, Eileen, 600 Makinen, Kauko K., 96 Nisbet, Louis J., 961 Hara, Tetsuro, 589 Kelly, Jesse P., 760 Maniatis, Antony, 515 Nohara, Chieko, 565 Harman, Colleen P., 125 Kende, Meir, 903 Mao, James C.-H., 197 Nolan, Charles, 37 Harmsen, Theo, 802 Keppeler, Hans, 632 Marconi, P., 625 Nombela, Cesar, 120 Hatris, Betty, 876 Kessler, R. E., 207 Marion, Patricia L., 277 Nord, Carl Erik, 943 Harris, B. H., 674 King, Charles H., 413 Markowitz, Sheldon M., 419 Norrby, S. Ragnar, 128 Harris, Deborah, 953 King-Thompson, Neva L., 42 Marks, Melvin I., 908 Nozawa, R. T., 132 Hatin, Isabelle, 561 Klein, Claire, 660 Marriott, Michael S., 832 Nugent, K. M., 692 Hawkins, Stephen S., 263 Klein, Richard J., 763 Marr, J. Joseph, 33 Nunn, Barbara, 858 Hayes, Nancy, 309 Knight, Susan S., 277 Marshall, Rosemarie, 640 Hedges, Robert W., 479 Knight, Vernon, 60, 309 Martin, Jerry R., 314 Oberg, Bo, 753 Heifets, Leonid B., 11 Knowlton, Douglas R., 306 Martin, Juan F., 380 O'Brien, Cheryl A., 583 Herrin, Thomnas R., 197 Kobasa, William D., 708 Martin, R. Russell, 953 Ogawa, Hidemasa, 473 Higgins, Peter G., 846 Kobayashi, George S., 172 Masters, P. J., 495 Ogawa, Midori, 541 Hill, Gale B., 324 Kobayashi, G. S., 302 Matsuda, Makoto, 650 Ogilvie, K. K., 184 Hoagland, Vicki L., 297 Kobayashi, Seiki, 65 Matsuhashi, Yuji, 589 Ohm-Smith, Marilyn J., 958 Ho, bah Hsi, 265 Koeppe, Peter, 375 Matthews, Thomas R., 277 Ohnuki, Tetsuo, 367 H6ffken, Gert, 375 Kohlhepp, Sue, 897 Mayer, Philip R., 812 Okamoto, Ryoichi, 612 Holland, Susan, 989 Kohnen, Paul W., 897 May, John W., 79 Okonogi, Kenji, 821 Holmes, King K., 203 Kondo, Masahiro, 821 Mayor, Gilbert, 897 Olsen, Kurt D., 431, 655 Holtsclaw-Berk, Shirley, 646 Konno, Masatoshi, 851 Mazzolla, R., 625 Ono, Yasuko, 921 Hori, Seiji, 650 Kraaijeveld, Cornelis A., 802 McCabe, Robert E., 491 Opheim, Kent E., 531 Hornstein, Michele J., 806 Krieger, John N., 332 McColm, Andrew A., 925 Osada, Hiroyuki, 230 Houang, Elizabeth T., 964 Kuhrt, M. F., 883 McCormack, William M., 724 Osada, Yasuaki, 473 Houghton, Donald C., 897 Kung, J. T., 184 McCoy, Leslie F., 769 Otani, Tsuyoshi, 473 Huang, Cheng-Hsiung, 460 Kuno, Mitsuzo, 821 McCracken, George H., Jr., 141, Otis, Ellen R., 197 Kurioka, Susumu, 650 431, 655 Ottolenghi, Abramo C., 399, 404, lida, Kyoko, 93 Kurtz, Harold J., 55 McDevitt, David A., 272 408 Ikeuchi, Toru, 473 Kwok, Y.-Y., 427 McKinlay, M. A., 883 Otto, M. J., 883 Imada, Akira, 821 McLarty, Jerry W., 912 Imanaka, Tadayuki, 367 LaFon, Stephen W., 33 Medeiros, Antone A., 479, 715 Pagano, Joseph S., 971 Ings, Robert M. J., 535 Laishley, Edward J., 863 Medoff, G., 302 Palomares, Jose C., 76 Innocent, Habyaremye, 388 Larsson, Alf, 753 Medoff, Gerald, 172 Parker, Steven W., 16 Inoue, Matsuhisa, 608, 612 Lawrence, Adam G., 964 Mellits, E. David, 217 Pasculle, A. William, 272 Inouye, Shigeharu, 589 Leathers, Timothy, 892 Mendelman, Paul M., 46 Pedler, Stephen J., 508 Iravani, Abdollah, 158, 449 LeBlanc, Barbara, 265 Mendez, Enrique, 791 Perea, tvelio J., 76 Iseman, Michael D., 11 LeBlanc, Donald J., 439 Menzies, Rosalie E., 672 Perlin, Michael H., 114 Ishitsuka, H., 595 LeBras, Jacques, 561 Merola, A. John, 399, 404, 408 Perlman, Alon M., 363 Isono, Kiyoshi, 230 Lecaillon, Jean-B., 177 Metras, Jacques, 928 Petrak, Russell M., 429 Iwanaga, Tomoaki, 93 Ledergerber, Bruno, 350, 353 Michel-Briand, Yvon, 280 Petzold, C. Rosemarie, 337 Lee, Ken, 652 Milhous, Wilbur K., 525 Pezzi, Nieves, 791 Jackson, Andre J., 977 Lee, Linda N., 439 Miller, F. DeWolfe, 102 Philippon, Alain M., 806 Jacobus, Nilda V., 968 Lefler, Eli, 363 Miller, Mahlon F., 314 Philips, Frederick S., 733 Jacoby, George A., 479, 715 Leitner, F., 207 Mills, John, 270, 648 Phillpotts, Robert J., 846 Janicke, David M., 16 Lemieux, Michel, 928 Mintz, Paul D., 125 Piehl, Evelyn, 337 Jantzen, Jan-Peter, 874 Lerner, Stephen A., 114, 670 Mirabelli, Christopher K., 460 Pijck, Jacques, 574 Jehl, Franqois, 503 Leslie, J., 605 Misiek, M., 207 Pinney, R. J., 985 Jensen, James B., 21 Lessard, Celine, 928 Mitsuhashi, Susumu, 473, 608, Pintado, Concepci6n, 120 Johansson, Nils-Gunnar, 753 Leung, Y. K., 872 612 Plorde, James J., 37 Johnson, Curtis A., 578 Levy, Jack, 46, 388 Mizuguchi, Yasuo, 541 Plorde, J. J., 739 Johnson, J., 468 Levy, Jean-Claude, 520 Modai, Jacques, 177 Prabhala, Rao H., 640 Johnson, Judith A., 774 Leyland-Jones, Brian, 733 Moellering, R. C., Jr., 28 Price, K. E., 207 Johnson, Kenneth, 874 Lietman, Paul S., 217 Moellering, Robert C., Jr., 357, Prinzing, Claus, 375 Johnson, Paulette, 314 Lindholm-Levy, Pamela J., 11 782 Puccetti, P., 625 Jokipii, Anssi M. M., 948 Lindqvist, Lennart, 943 Monteil, Henri, 503 Pugsley, Anthony P., 666 Jokipii, Liisa, 948 Lin, Jung-Chung, 971 Monto, Arnold S., 102 Pursiano, T. A., 207 Jones, J., 966 Little, J. R., 302 Moore, Richard D., 217 Jones, Mary, 646 Livermore, D. M., 872 Mordenti, Joyce, 887 Quarles, John M., 309 Jones, Ronald N., 413, 679, 982 Lockerby, Deirdre L., 863 Murakami, Kazuhisa, 727 Jonsson, Monica, 128 Lode, Hartmut, 375 Myers, Carolyn M., 583 Rabin, Harvey R., 863 Joos, Beda, 350, 353 Longfield, Jenice N., 652 Rakusan, Tatnara A., 181 Joshi, J., 605 Looker, Douglas L., 33 Nacucchio, Marcelo C., 137 Ramfrez-Ronda, Carlos H., 246, Jouvenot, Michelle, 280 L6pez-Nieto, Manuel J., 380 Nagata, Akihisa, 921 570 Jupeau, Annie M., 806 Louv, William C., 760 Nakanishi, Hiroshi, 93 Ramos, Filomena R., 380 Jusko, William J., 16 Lozano, Maria C., 76 Nam, Doo H., 798 Randall, Eileen, 424 Lu, Y.-S., 436 Natelson, Ethan A., 683 Rao, Bhavani, 640 Kadurugamuwa, Jagath L., 220 Luft, Friedrich C., 812 Needham, Cynthia A., 499 Rastogi, Nalin, 701 Kany, Robert J., Jr., 1 Luman, J. Ileice, 912 Nelson, Donald J., 33 Rayburn, William, 337 Kaplan, Raymond L., 429 Luthy, Ruedi, 350, 353 Nesbit, Robert R., 487 Raymond, Gilles, 928 Karney, Walter W., 652 Lyon, Bruce R., 79 Nevarez, Minerva, 246 Reed, Michael D., 583 Kasbekar, Durgadas P., 974 Newton, Bruce R., 449 Reeves, William C., 203 Kato, H., 132 MacCulloch, Donald, 672 Ng, Wilson W. S., 872 Reinhardt, John F., 643, 966 Katz, Eugene, 974 Macdonald, Cameron M., 535 Nickel, J. C., 619 Rein, Michael F., 332 Kaye, Donald, 708 MacGregor, Rob Roy, 745 Nikaido, Hiroshi, 84, 393 Reiszner, E., 28 Kazuno, Yuzo, 589 Madigan, Sanford, 974 Ninomiya, Y, 595 Remington, Jack 5., 491 VOL. 27, 1985 AUTHOR INDEX iii A., 733 Sievers, Gunnel, 96 Tauber, William B., 652 Watanabe, Kyoichi Remington, Michael L., 203 Norman F., 525 Rench, Marcia A., 511 Singh, S. K., 239 Tennent, Jan M., 79 Weatherly, Reynolds, Rolfe B., 760 Skold, Ola, 933 Tenover, Fred C., 37, 739 Weber, Allan, 531 Ronald A., 79 Tenovuo, Jorma, 96 Weinberg, Winkler G., 652 Richard, George A., 158, 449 Skurray, 695 Richardson, Kenneth, 832 Slocombe, B., 495 Thadepalli, Haragopal, 640 Weisholtz, Steven, Smee, Donald F., 277 Thauvin, Claudie, 357 Welch, David F., 908 Rill, Wayne L., 903 D., 874 Rissing, J. Peter, 487 Smith, Arnold L., 46, 531 Thierry, Robert C., 503 Welch, William Smith, Craig R., 217 Thomas, Debra, 125 Welling, Peter G., 578 Robinson, William S., 277 449 Rodriguez, Fernando C., 282 Smith, L. Patrick, 652 Thornsberry, Clyde, 679 Welty, Gina S., Smith, M. Carolyn, 971 Threlkeld, Norma, 431 Wentland, Mark P., 4 Rodriguez, Julie R., 246, 570 H., 846 Rogge, Mark C., 578 Smith, Sharon M., 688 Toda, Masato, 565 Werner, Georges Rollins, Larry D., 439 Snippe, Harm, 802 Tomasz, Alexander, 695 Werner, Vicki, 455 Roselle, Gary A., 291 Socransky, Sigmund S., 663 Tonin, Enrico, 828 Wexler, H., 674 Rosenstock, Joel, 652 Sommers, Herbert M., 982 Traub, B., 879 Wexler, Hannah M., 876 Rossi, Lucia, 828 Sordelli, Daniel O., 137 Trenholme, Gordon M., 429 Whalen, J. W., 239 Rotgef, Rafael, 120 Spector, Stephen A., 600 Troke, Peter F., 832 White, A. R., 495 Speelman, Peter, 227 Tsai, Y. H., 207 Widger, William R., 836 Rouan, Marie-C., 177 419 Ruhr, Elke, 841 Srivastava, Sujan, 102 Tsuji, Akioyoshi, 515 Williams, Denise S., Ruseska, I., 619 Stagno, Sergio, 760 Tuner, Kajsa, 943 Williams, Linda, 733 Rusnak, Michael G., 340 Stamm, Walter E., 203 Turcan, Robert G., 535 Williams, Michael E., 125 Ruxer, R., 605 Standiford, H., 605 Twitty, James A., 817 Williams, Sue, 37 Ryan, D. Michael, 925 Staneck, Joseph L., 291 Tyrrell, David A. J., 846 Willis, Greg, 309 Stapleton, M. J., 468 Willmann, John S., 846 Ryder, Neil S., 252 W., 912 Ryu, Dewey D. Y., 798 Steele, Lorraine C., 912 Ubukata, Kimiko, 851 Wilson, Rebecca Steen, Rolf, 933 Udou, Takezo, 541 Wilson, Samuel Z., 60, 309 Sabbaj, Jacobo, 297 Stern, Robert C., 583 Umeda, I., 595 Wofsy, Constance B., 648 Sahl, Hans-G., 836, 841 Stevens, David A., 363 Une, Tsutomu, 473 Wong, Justina, 749 Sakata, Yasutaka, 141, 655 Stevenson, Roselynn M. W., 938 Wood, Bruce A., 683 Salvador, Concepci6n, 120 Stone, Benjamin B., 343 Vaara, Martti, 548 Wood, N. C., 692 Sande, Merle A., 135, 224, 320, Stull, Terrence L., 46 Vallner, Joseph J., 487 Wyde, Philip R., 60 340, 452, 685 Sugi, H., 132 van Tiel, Frank H., 802 Sander, Donna S., 306 Suhara, Y., 595 Varaldo, Pietro Emanuele, 615 Yamada, Hozumi, 93 Sanders, Christine C., 455 Sullam, Paul M., 135, 224, 320, Varner, Michael, 337 Yamada, Takeshi, 921 Sanders, W. Eugene, Jr., 455 685 Vecchiarelli, A., 625 Yamaguchi, Masaya, 93 San Joaquin, Venusto H., 908 Sullivan, Robert, 291 Venezio, Frank R., 712 Yamanouchi, Takahisa, 921 Sato, Kenichi, 473, 608, 612 Sun, Chong-Son, 60 Verdier, Francoise, 561 Yamashita, Naoko, 851 Sato, Masamichi, 473 Sun, Ming, 192 Verghese, Abraham, 499 Yamashita, Toyoko S., 583 Scavizzi, Maurice R., 806 Susaki, Kiyoshi, 565 Vertut-Croquin, Aline, 172 Yisak, Wolde-Ab, 753 Schimpff, S., 605 Sutherland, R., 495 Vidal, Pedro M., 733 Yokota, T., 132 Schito, Gian Carlo, 615 Sutter, Vera L., 424, 427 Viljanen, Petri, 548 Yoshida, Tadashi, 589, 727 Schlessinger, David, 172 Suzuki, Yasuhiko, 921 Visscher, David, 812 Yoshimura, Fuminobu, 84 Schmidt, L. H., 146, 151 Swartz, Glenn M., Jr., 903 von Esch, Anne M., 197 Young, Charles W., 733 Schoeller, Jean-P., 177 Sweeney, Kristin G., 499 Vontver, Louis A., 203 Young, Lowell S., 515 Schwartz, Daniel R., 172 Sweet, Richard L., 958 Vorland, Lars H., 107 Young, Stephen A., 739 Scott, Kenyon G., 340, 452, 685 Sykes, Richard B., 555 Vu, Hanh, 393 Yukishige, Koichi, 821 Segreti, John, 429 Sypherd, Paul S., 892 Vuye, Armand, 574 Shafran, Stephen D., 749 Zabransky, R. J., 424 Shalit, Itamar, 908 Tachibana, Akio, 565 Waddell, David, 916 Zajac, Barbara A., 745 Shelley, M. D., 275 Takeuchi, Tsutomu, 65 Wade, J., 605 Zak, Oto, 220 Shih, W. J., 297 Tally, Francis P., 968 Wagner, Roland B., 4 Zar, Fred A., 1 Shimada, Jingoro, 650 Tanabe, Masanobu, 65 Wallace, Richard J., Jr., 912, 953 Zerial, Aurelio, 846 Shipkowitz, Nathan L., 197 Tanaka, S. Ken, 555 Ward, Gilbert E., 55 Zhou, Hong-Hao, 192 Shoeb, Hussein A., 399, 404, 408 Tauber, Martin G., 135, 224, Ward, Richard L., 306 Zimmerman, Stephen W., 578 Siegenthaler, Walter, 353 320, 340, 685 Warren, Richard L., 468 Zinner, Stephen H., 343 SUBJECT INDEX VOLUME 27

A21978C, high-pressure liquid chromatography, enteropathogens, 388 in vitro activity, 357 977 experimental infections mechanism of action, 357 E. coli Kl, 655 AC 1370 - H. influenzae type b, 655 see cefpimizole bacteriuria, 508 meningitis, 655 2-Acetylpyridine thiosemicarbazones B. catarrhalis, 912 gonorrhea, 265 N. gonorrhoeae, 570 H. influenzae, 912 P. aeruginosa, 1, 872 Acyclovir lower respiratory tract infections, 912 penetration into bronchial secretions, combined with vidarabine, 600 Amphotericin B 263 cytomegalovirus, 600 comparative activity, 302, 363 pharmacokinetics, 16 experimental infections erythrocyte lysis, 172 herpes simplex virus, 167 experimental infections Adenylyl dihydrostreptomycin blastomycosis, 363 BA-41,799 accumulation in E. coli, 114 C. albicans, 625 experimental infections Aeromonas hydrophila immunoadjuvant activity, 625 malaria, 146 P-lactamases methyl ester P. cynomolgi, 146 AER-1, 479 comparative activity, 302 Bacillus cereus -hydrolyzing, 479 N-D-ornithyl, 302 lactoperoxidase, 96 Aeromonas spp. oxidative damage, 172 myeloperoxidase, 96 ciprofloxacin, 643 rapid infusion Bacillus circulans enoxacin, 643 ventricular fibrillation, 868 butirosin norfloxacin, 643 biosynthesis, 798 tetracycline, 643 Campylobacter spp., 429 sporulation, 798 trimethoprim-sulfamethoxazole, 643 combined with Bacteriodes spp. African trypanosomes anaerobic bacteria, 876 , 968 inosine analogs, 33 comparative activity, 429 Bacteriuria Alafosfalin Anaerobic bacteria amoxicillin-clavulanic acid, 508 anaerobic bacteria, 961 alafosfalin, 961 pregnancy, 508 Alcaligenes faecalis ampicillin Bay 1 9139 ,-lactamase, 608 cefbuperazone, 162, 640, 674, 749 comparative activity, 363 Alveolar macrophages ciprofloxacin, 427 experimental infections uptake, 42 female genital tract infections blastomycosis, 363 smokers, 42 antimicrobial susceptibilities, 324 Bay n 7133 AMA-1080 HR 810, 413 comparative activity, 363 see moxalactam MICs, 424 experimental infections Amifloxacin quinolones, 657 blastomycosis, 363 antibacterial activity, 4 Sch 34343, 749 BCG vaccine comparative activity, 449 sulbactam herpes simplex virus infections, 203 disposition in laboratory animals, 774 Antiglobulin tests Bioassay E. coli, 449 clavulanic acid, 125 ciprofloxacin, 353 high-pressure liquid chromatography, Antimalarial drugs comparative studies, 353 769 antifol BIOLF-70 in vitro activity in vitro activity, 525 antimyocarditic activity, 184 culture medium, 449 mechanism of resistance, 525 experimental infections inoculum size, 449 P. falciparum, 21 coxsackievirus, 184 pH changes, 449 Antimycotic agents Bismuth salts metabolism, 774 SF 86-327, 252 echovirus, 306 pharmacokinetics, 769 Antiviral agents poliovirus, 306 S. saprophyticus, 449 enzyme immunoassay, 802 reovirus, 306 urinary tract infections, 449 MICs, 802 rotavirus, 306 Amikacin Apalcillin Bis-triazole concentrations in body fluids comparative activity, 782 derivatives pentobarbital, 720 platelet function, 683 UK-49,858, 832 renal disposition, 520 Aphidicolin Bithionol b-(L-Aminoadipyl)-L-cysteinyl-D-valine herpesvirus DNA polymerase, 445 G. lamblia, 65 conversion to isopenicillin N, 380 Arabinosyladenine monophosphate T. vaginalis, 65 -y-Aminobutyric acid ground squirrel hepatitis virus, 277 Blastomycosis , 650 virion-associated DNA polymerase re- experimental rat synaptic membranes, 650 duction, 277 amphotericin B, 363 Aminoglycosides Ascamycin Bay 1 9139, 363 2"-O-nucleotidyltransferase mechanism of action, 230 Bay n 7133, 363 enzymatic modification, 670 selective toxicity, 230 ICI 153066, 363 resistance, 670 2-Azahypoxanthine ketoconazole, 363 3-phosphotransferase high-pressure liquid chromatography, Bleomycin DNA probes, 739 977 E. coli DNA breakage, 460 structural genes, 739 plasmid R6K elimination, 985 polymorphonuclear leukocytes, 712 combinations BMY-25182 pseudodisaccharide clindamycin, 246 see cefbuperazone dactimicin, 589 respiratory tract infections, 246 BMY-28142 renal disposition, 520 comparative activity, 1, 388, 872 comparative activity, 207, 515 5-Aminoimidazole-4-carboxamide endocarditis, 1 experimental infections iv VOL. 27, 1985 SUBJECT INDEX v

meningitis, 340 M. avium-intracellulare, 132 moxalactam, 337 in vitro activity, 265, 574, 679 pleural fluid Chlamydia trachomatis Branhamella catarrhalis clearance, 93 growth inhibition, 953 amoxicillin-clavulanic acid, 912 penetration, 93 HeLa cells, 953 antibiotic susceptibility, 499 human prostate cells, 953 comparison with colonizing isolates, 499 M. tuberculosis, 11 McCoy cells, 953 3-lactamase-positive, 912 pharmacokinetics, 487 nonoxynol-9, 720, 760 ,B-lactamase production, 646 protein binding, 487 zinc, 953 lower respiratory tract infections, 912 Chloramphenicol pneumonia, 499 Campylobacter spp., 429 Campylobacter spp., 429 R plasmid, 120 comparative activity, 429 comparative activity, 429 susceptibility, 646 experimental infections H. influenzae, 46 Butirosin meningitis, 340 resistance biosynthesis, 798 valvular lesions, 320 permeability barrier, 46 sporulation, 798 M. avium-intracellulare, 132 Chloroquine resistance test, 672 erythrocytes uptake, 561 Campylobacter coli pharmacokinetics, 177 P. falciparum, 561 resistance factors, 37 Cefpimizole Chlorpromazine R plasmids, 37 clinical isolates, 982 Candida spp., 692 Campylobacter jejuni comparative activity, 982 Cilastatin resistance factors, 37 experimental infections combined with R plasmids, 37 meningitis, 340 pharmacokinetics, 511 Campylobacter spp. cystic fibrosis patients, 583 ampicillin, 429 comparative activity, 782 imipenem- antimicrobial agent activity, 55 high-dose treatment, 745 cefotaxime, 429 comparative activity, 1 pharmacokinetics, 431 cephalothin, 429 endocarditis, 1 pharmacokinetics, 583 chloramphenicol, 429 P. aeruginosa, 1 Ciprofloxacin ciprofloxacin, 429 renal interaction, 660 absorption, 350 clindamycin, 429 urinary pH, 660 Aeromonas spp., 643 doxycycline, 429 anaerobic bacteria, 427 erythromycin, 429 cancer patients, 605 bioassay, 353 gentamicin, 429 cardiac vegetations, 925 Campylobacter spp., 429 nalidixic acid, 429 combinations comparative activity, 388, 427, 429 pigs, 55 , 605 enteropathogens, 388 sulbactam, 429 tobramycin, 605 experimental infections trimethroprim-sulfamethoxazole, 429 fibrin clots, 925 P. aeruginosa, 452 Cancer patients pharmacokinetics, 605, 925 pneumonia, 452 ceftazidime pharmacokinetics, 605 high-pressure liquid chromatography, Candida albicans M. avium-intracellulare, 132 353, 531 experimental infections pharmacokinetics, 350, 375 amphotericin B, 625 pediatric infections, 181 P. shigelloides, 643 UK-49,858, 832 pharmacokinetics, 192 S. aureus, 688 Candida spp. skin infections, 648 Citrobacter freundii chlorpromazine, 692 soft tissue infections, 648 cephalosporinase, 727 Carbenicillin urinary tract infections, 158 moxalactam, 727 hydrolysis by ,B-lactamase Cephalosporinases Clavulanic acid A. hydrophila AER-1, 479 C. freundii, 727 amoxicillin- Carumonam moxalactam binding, 727 B. catarrhalis, 912 antibacterial activity, 821 Cephalosporins H. influenzae, 912 -y-aminobutyric acid inhibition, 650 lower respiratory tract infections, 912 cardiac surgery, 928 BMY-28142, 679 antiglobulin tests, 125 concentration in atrial appendages, 928 broad-spectrum combined with amoxicillin BMY-28142, 265 bacteriuria, 508 prophylaxis DN-9550, 473 efficacy, 291 cesarean section, 337 half-lives, 887 safety, 291 Cefbuperazone HR 810, 388 Clindamycin anaerobic bacteria, 162, 640, 674, 749, M. tuberculosis, 11 Campylobacter spp., 429 817 rat synaptic membranes, 650 combinations Bacteriodes spp., 968 subinhibitory concentrations aerobic gram-negative bacilli, 246 comparative activity, 162, 817 K. pneumoniae, 220 aztreonam, 246 female genital tract isolates, 958 Cephalothin respiratory tract infections, 246 P-lactamase contribution to resistance, Campylobacter spp., 429 tobramycin, 246 817 comparative activity, 429 comparative activity, 429 Clofazimine M. chelonei, 282 cefbuperazone, 640 prostaglandins, 257 M. fortuitum, 282 Clostridium difficile M. avium-intracellulare susceptibility, L-Cysteine, 419 experimental infections 132 , 419 comparative activity, 708 Cesarean section Clostridium pasteurianum E. aerogenes, 708 prophylaxis metronidazole reduction, 863 endocarditis, 708 cefazolin, 337 phosphoroclastic reaction, 863 vi SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Cloxacillin phosphonoformate, 445 Erythromycin cardiac surgery, 928 nucleoside analogs, 416, 445 Campylobacter spp., 429 concentration in atrial appendages, 928 DNA probes comparative activity, 429 aminoglycoside 3-phosphotransferase resistance M. aurum, 701 structural genes, 739 L. micdadei, 272 Colitis Doxycycline L. pneumophila, 272 experimental Campylobacter spp., 429 streptococci , 980 comparative activity, 429 resistance determinant, 439 Continuous ambulatory peritoneal dialysis tissue culture cells pharmacokinetics, 578 accumulation, 314 Coxsackievirus Echovirus egress, 314 experimental infections bismuth salts, 306 uptake, 314 BIOLF-70, 184 Edwardsiella tarda Escherichia coli Cyclic lipopeptide comparative activity of selected antimi- adenylyl dihydrostreptomycin accumula- A21978C1, 357 crobial agents, 966 tion, 114 L-Cysteine Endocarditis amifloxacin, 449 C. difficile, 419 experimental bleomycin, 460 penicillin, 419 cefoperazone, 708 cytoplasmic membrane, 666 Cystic fibrosis E. aerogenes, 708 DNA breakage, 460 cilastatin, 583 enoxacin, 708 experimental infections imipenem, 583 gentamicin, 224 aztreonam, 655 Cytomegalovirus pefloxacin, 685 meningitis, 655 acyclovir, 600 S. aureus, 685 13-lactam diffusion, 84 vidarabine, 600 , 135 microcin E492, 666 Enoxacin peptides Aeromonas spp., 643 microcin 7, 791 Dacarbazine experimental infections porin channels, 84 degradation product comparative activity, 708 resistance, 107 2-azahypoxanthine, 977 E. aerogenes, 708 R plasmids high-pressure liquid chromatography, endocarditis, 708 cloning from S. aureus, 79 977 P. shigelloides, 643 urinary tract infections, 107 metabolite Enteric viruses spheroplasts, 114 5-aminoimidazole-4-carboxamide, 977 bismuth salts, 306 talisomycin, 460 Dactimicin Enterobacter aerogenes tetracycline resistance comparative activity, 589 experimental infections TnJO-mediated, 879 Dapsone cefoperazone, 708 urinary tract infections, 107, 449 prostaglandins, 257 endocarditis, 708 whole cells, 114 [2-"C]-(2-Deoxy-2-fluoro-o-D-arabinofur- enoxacin, 708 ["C]Ethanol anosyl)-5-iodocytosine Enterobacter cloacae "CO, production, 535 biotransformation, 733 ,B-lactamases, 393, 455 Experimental infections elimination, 733 3-lactams blastomycosis herpesvirus infections, 733 hydrolylsis, 393 amphotericin B, 363 immunosuppressed patients, 733 penetration, 555 Bay 1 9139, 363 Dibekacin resistance, 455 Bay n 7133, 363 renal disposition, 520 mechanism of resistance, 393 ICI 153066, 363 cis-Dichlorodiammineplatinum (II) outer membrane proteins, 455 ketoconazole, 363 biliary excretion, 275 Enterococci C. albicans 4,6-Dichloroflavin Sch 34343, 28 amphotericin B, 625 comparative activity, 595 trimethoprim UK-49,858, 832 mechanism of action, 595 alone, 71 colitis Dichlorophene with sulfamethoxazole, 71 temocillin, 980 G. lamblia, 65 Enteropathogens coxsackievirus T. vaginalis, 65 aztreonam, 388 BIOLF-70, 184 Dictyostelium discoideum ciprofioxacin, 388 endocarditis nystatin resistance, 974 HR 810, 388 cefoperazone, 708 9-(3,4-Dihydroxybutyl)guanine norfloxacin, 388 E. aerogenes, 708 enantiomers ofloxacin, 388 enoxacin, 708 antiherpesvirus effects, 753 RU28965, 388 enterococci, 135 pharmacokinetics, 753 Enviroxime gentamicin, 224 9-(1,3-Dihydroxy-2-propoxymethyl)- comparative activity, 595 pefloxacin, 685 guanine mechanism of action, 595 S. aureus, 685 ground squirrel hepatitis virus, 277 rhinovirus infections, 102 teicoplanin, 135 herpes simplex virus Enzyme immunoassays herpes simplex virus infections in mice, 763 antiviral agents, 802 acyclovir, 167 latency, 763 monoclonal antibodies, 802 malaria virion-associated DNA polymerase re- Epstein-Barr virus BA-41,799, 146 duction, 277 DNA polymerase, 416 P. cynomolgi, 146 DN-9550 nucleoside analogs, 416, 971 meningitis in vitro activity, 473 Erythrocytes aztreonam, 655 DNA polymerase amphotericin B, 172 BMY-28142, 340 Epstein-Barr virus, 416 chloroquine uptake, 561 cefotaxime, 340 herpesvirus lysis, 172 cefpimizole, 340 aphidicolin, 445 oxidative damage, 172 E. coli Kl, 655 VOL. 27, 1985 SUBJECT INDEX vii

H. influenzae type b, 655 chloramphenicol, 46 metabolism, 33 pneumococcal, 340 experimental infections tissue culture efficacy, 33 S. pneumoniae, 141 aztreonam, 655 Interferon pneumonia meningitis, 655 aerosol, 60 ciprofloxacin, 452 P-lactamase-positive, 912 vesicular stomatitis virus, 60 P. aeruginosa, 452 lower respiratory tract infections, 912 pefloxacin, 452 resistance M. tuberculosis oxygen generation, 404 T. mentagrophytes permeability barrier, 46 oxidation UK-49,858, 832 HeLa cells mediation by peroxidase, 399 valvular lesions C. trachomatis inhibition, 953 superoxide-generating reactions, 408 cefotaxime, 320 Herpes simplex virus Isopenicillin N BCG vaccine, 203 conversion from 8-(L-aminoadipyl)-L- DNA polymerase cysteinyl-D-valine, 380 Flavobacterium odoratum aphidicolin, 445 P. chrysogenum, 380 ,-lactamase, 612 nucleoside analogs, 445 Fluoroquinolones phosphonoformate, 445 WIN 49375 experimental infections Ketoconazole antibacterial activity, 4 acyclovir, 167 comparative activity, 363 Formycin B 9-(1,3-dihydroxy-2-propoxymethyl)- experimental infections T. cruzi, 491 guanine, 763 blastomycosis, 363 Fusidic acid latency, 763 Klebsiella pneumoniae cardiac surgery, 928 genital infections, 203 cephalosporins, 220 concentration in atrial appendages, 928 Herpesvirus iron-depleted, 220 Fusobacterium nucleatum 12-'1C]-(2-deoxy-2-fluoro-o-D-arabinofu- siderophore production, 220 1-lactamase, 943 ranosyl)-5-iodocytosine surface properties, 220 biotransformation, 733 elimination, 733 Garlic 9-(3,4-dihydroxybutyl)guanine, 753 1-Lactamases Allium sativum 9-(4-hydroxybutyl)guanine, 753 AER-1, 479 mycobacterial inhibition, 485 Hexachlorophene A. faecalis, 608 Genital pathogens G. lamblia, 65 B. catarrhalis, 646 quinoline derivatives, 76 T. vaginalis, 65 E. cloacae resistance, 393, 455 Genital tract infections High-pressure liquid chromatography F. nucleatum, 943 female amifloxacin, 769 F. odoratum, 612 anaerobic bacterial susceptibility, 324 5-aminoimidazole-4-carboxamide, 977 induction test, 672 Gentamicin 2-azahypoxanthine, 977 1-lactam hydrolysis, 393 Campylobacter spp., 429 ciprofloxacin, 353, 531 OXA-2 comparative activity, 429 comparative studies, 353 dacarbazine, 977 immunological comparison, 989 experimental infections OXA-4, 715 endocarditis, 224 HR 810, 436 nephrotoxicity, 812 vancomycin, 503 OXA-5, 715 P. aeruginosa extracellular proteases, HR 810 OXA-6, 715 468 anaerobic bacteria, 413 OXA-7, 715 pharmacokinetics, 285 comparative activity, 388 TLE-1, 715 renal accumulation, 812 enteropathogens, 388 P-Lactams renal disposition, 520 high-pressure liquid chromatography, anaerobic bacteria, 817 Giardia lamblia 436 comparative activity, 1, 817, 872 bithionol, 65 pharmacokinetics, 436 disulfiram-like effects in rats, 535 dichlorophene, 65 Human prostate cells E. cloacae giardiasis, 227 C. trachomatis inhibition, 953 penetration, 555 growth inhibition, 65 9-(4-Hydroxybutyl)guanine resistance, 393, 455 hexachlorophene, 65 antiherpesvirus effects, 753 E. coli porin channels, 84 tinidazole, 227 pharmacokinetics, 753 endocarditis, 1 Giardiasis expanded-spectrum, 393 G. lamblia, 227 hydrolysis, 393 tinidazole, 227 ICI 153066 L. pneumophila, 695 Gonorrhea comparative activity, 363 M. avium-intracellulare complex, 541 aztreonam, 265 experimental infections Gram-negative bacteria blastomycosis, 363 P. aeruginosa, 1, 872 B nonapeptide, 541 Imipenem N-sulfonated monocyclic Gram-positive bacteria -cilastatin carumonam, 821 Sch 34343, 28 pharmacokinetics, 431, 511 Y. enterocolitica, 806 Ground squirrel hepatitis virus comparative activity, 1 Lactoperoxidase arabinosyladenine monophosphate, 277 cystic fibrosis patients, 583 B. cereus, 96 9-(1,3-dihydroxy-2-propoxymethyl)guanine, endocarditis, 1 Legionella micdadei 277 high-dose treatment, 745 erythromycin-resistant, 272 Guanine P. aeruginosa, 1 Legionella pneumophila derivatives pharmacokinetics, 583 erythromycin-resistant, 272 BIOLF-70, 184 Influenza virus P-lactams, 695 ribavirin aerosol, 309 Leishmania spp. Inosine sodium stibogluconate, 916 Haemophilus influenzae analogs Liposomes amoxicillin-clavulanic acid, 912 African trypanosomes, 33 piperacillin activity, 137 viii SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

Macrolide antibiotics cefmetazole, 282 Pefloxacin RU28965, 388 Mycobacterium fortuitum experimental infections Malaria susceptibility endocarditis, 685 antifol drugs, 525 cefmetazole, 282 P. aeruginosa, 452 experimental Mycobacterium tuberculosis pneumonia, 452 BA-41, 799, 146 ceforanide, 11 S. aureus, 685 P. cynomolgi, 146 cephalosporins, 11 McCoy cells isoniazid, 404 Sch 34343, 28, 128 C. trachomatis inhibition, 953 oxygen generation, 404 Penicillin Membrapes ribosome alteration, 921 C. difficile, 419 cytoplasmic RNA polymerase, 9Mt L-Cysteine, 419 nisin, 841 susceptibility S. pneumoniae susceptibility whole cell radiometry, 11 experimental meningitis, 141 nisin, 841 Myeloperoxidase streptococci Meningitis B. cereus, 96 reverse inoculum effect, 948 experimental Penicillin-binding proteins aztreonam, 655 activity regulation, 828 BMY-28142, 340 Nalidixic acid P-lactan-inducible, 851 cefotaxime, 340 Campylobacter spp., 429 -inducible, 828 cefpimizole, 340 comparative activity, 429 S. aureus, 828 E. coli Kl, 655 Neisseria gonorrhoeae staphylococci, 851 H. influenzae type b, 655 2-acetylpyridine thiosemicarbazones, Penicillium chrysogenum pneumococcal, 340 570 isopenicillin N synthetase, 380 S. pneumoniae, 141 Neisseria spp. Pentobarbital Metronidazole R plasmid, 120 amikacin concentrations in body fluids, C. pasteurianum phosphoroclastic re- Nephrotoxicity 720 action, 863 gentamicin, 812 Pep-5 reduction, 863 netilmicin, 812 structural similarities to nisin, 836 Microcin 7 tobramycin, 812 Peptide antibiotics mode of action, 791 Netilmicin nisin, 836, 841 structure, 791 kinetic model, 343 Pep-5, 836, 841 Microcin E492 nephrotoxicity, 812 Peroxidase E. coli cytoplasmic membrane, 666 renal accumulation, 812 isoniazid oxidation, 399 Mirincamycin renal disposition, 520 Pharmacokinetics primaquine activity enhancement, 151 Nisin amifloxacin Mitochondrial inhibitors membranes monkeys, 769 P. falciparum, 21 cytoplasmic vesicles, 841 aztreorlam whole cells, 841 gram-negative infections, 16 half-lives, 887 mode of action, 841 cefazolin Moxalactam structural similarities to Pep-S, 836 effects of anestheia, 874 anaerobic bacteria, 424 Nonoxynol-9 orthopedic surgery patients, 874 bleeding times, 858 C. trachomatis, 720, 760 ceforanide cephalosporinase binding, 727 Norfloxacin intraoperative, 487 C. freundii, 727 Aeromonas spp., 643 pr-otein binding, 487 MICs, 424 comparative activity, 388, 419 cefotiam platelet responsiveness, 858 enteropathogens, 388 humans, 177 pleural fluid P. shigelloides, 643 ceftazidime clearance, 93 urinary tract infections, 297, 419 cancer patients, 605 penetration, 93 Nucleoside analogs cardiac vegetations, 9'5 prophylaxis Epstein-J3arr virus, 416, 971 fibrin clots, 925 cesarean section, 337 herpesvirus DNA polymerase, 445 ceftriaxone susceptibility testing 5-triphosphates, 416 Chinese adults, 192 agar dilution, 424 Nucleoside antibiotics cilastatin microdilution, 424 ascamycin, 230 combined with imipenem, 511 Mucor racemosus 2"-O-Nucleotidyltransferase cystic fibrosis patients, 583 resistance, 892 aminoglycosides neonates, 431, 511 Mupirocin enzymatic modificatiop, 670 ciprofloxacin antibacterial activity, 495 resistance, 670 absorption, 350 Mycobacteria Nystatin administration routes, 375 inhibition D. discoideum resistance, 974 effect of breakfast, 350 garlic (A. sativum), 485 multiple-dose, 350 Mycobacterium aurum 9-(3,4-dihydroxybutyl)guanine, 753 colistin, 701 Ofloxacin gentamicin Mycobacterium avium-intracellulare comparative activity, 388 drug abusers, 285 cefoperazone, 132 enteropathogens, 388 HR 810 cefotaxime, 132 Oral microbes rabbits, 436 ceftizoxime, 132 sangvinarine, 663 9-(4-hydroxybutyl)guanine, 753 susceptibility, 132 Outer membrane proteins imipenem complex E. cloacae, 455 combined with cilastatin, 511 P-lactams, 541 cystic fibrosis patients, 583 morphological changes, 541 neonates, 431, 511 Mycobacterium chelonei Pediatric infections netilmicin susceptibility ceftriaxone, 181 two-compartment model, 343 VOL. 27, 1985 SUBJECT INDEX ix

tobramycin nonapeptide Rift Valley fever virus, 903 drug abusers, 285 gram-negative bacteria, 541 Ribosomes vancomycin Polymyxin E M. tuberculosis, 921 continuous ambulatory peritoneal di- see colistin Rifampin alysis, 578 Pregnancy combinations, 615 peritoneal drug transport, 578 bacteriuria, 508 staphylococci, 615 Phosphonoacetate Primaquine Rifapentine structure-activity studies, 197 activity enhancement combinations, 615 Phosphonoformate mirincamycin, 151 staphylococci, 615 herpesvirus DNA polymerase, 445 Probenecid Rift Valley fever virus Picornavirus renal interaction, 660 ribavirint, 903 WIN 51711, 883 urinary pH, 660 RMI-15,731 Piperacillin Prodrugs comparative activity, 595 combined with ceftazidime alafosfalin, 961 mechanism of action, 595 cancer patients, 605 Prostaglandins RNA polymerase liposome-mediated activity, 137 clofazimine, 257 M. tuberculosis, 921 staphylococci, 137 dapsone, 257 Ro 09-0179 Plasmids polymorphonuclear leukocytes, 257 comparative activity, 595 R6K mechanism of action, 595 elimination by bleomycin, 985 aztreonam, 1, 872 Ro 09-0410 resistance cefsulodin, 1 comparative activity, 595 B. catarrhalis, 120 endocarditis, 1 mechanism of action, 595 C. coli, 37 experimenital infections Ro 17-2301 C. jejuni, 37 ciprofloxacin, 452 comparative activity, 872 E. coli, 79, 107 pefloxacin, 452 P. aeruginosa, 872 Neisseria sp., 120 pneumonia, 452 Rotavirus S. aureus, 79 extracellular proteases, 468 bismuth salts, 306 staphylococci, 234 gentamicin, 468 44 081 R.P. tetracycline imipenem, 1 cell cultures, 846 trimethoprim resistance ,-lactams, 1, 872 RU28965 Tn7, 933 peritoneal dialysis, 908 comparative activity, 388 Plasmodium cynomolgi Ro 17-2301, 872 enteropathogens, 388 experimental infections , 1 BA-41, 799, 146 tobramycin malaria, 146 extracellular proteases, 468 Sanguinarine Plasmodium falciparum resistance, 619 comparative activity, 663 antimalarial activity urinary catheters, 619 oral microbes, 663 oxygen-dependent, 21 Pseudomonic acid Sch 34343 time-dependent, 21 antibacterial activity, 495 anaerobic bacteria, 749 chloroquine comparative activity, 28, 128 resistance, 561 enterococci, 28 uptake, 561 Quinolines gram-positive bacteria, 28 erythrocytes, 561 derivatives SF 86-327 mitochondrial inhibitors, 21 genital pathogens, 76 fungal sterol biosynthesis, 252 Platinum Quinolones mechanism of action, 252 biliary excretion, 275 anaerobic bacteria, 657 Skin infections cis-dichlorodiammineplatinum (II), 275 comparative activity, 657 ceftriaxone, 648 Plesiomonas shigelloides Sodium stibogluconate ciprofloxacin, 643 biochemical mechanisms, 916 enoxacin, 643 Radiometry Soft tissue infections norfloxacin, 643 M. tuberculosis susceptibility, 11 ceftriaxone, 648 tetracycline, 643 Reovirus Spermicides trimethoprim-sulfamethoxazole, 643 bisnmuth salts, 306 nonoxynol-9, 760 Pneumococci Resistance factors Staphylococci experimental infections C. coli, 37 coagulase-negative BMY-28142, 340 C. jejuni, 37 R plasmids, 234 cefotaxime, 340 Respiratory tract infections tetracycline, 234 cefpimizole, 340 amoxicillin-clavulanic acid, 912 methicillin-resistant meningitis, 340 aztreonam, 246' penicillin-binding protein, 851 Pneumonia B. catarrhalis, 912 piperacillin, 137 B. catarrhalis, 499 clindamycin, 246 Staphylococcus aureus experimental H. influenzae, 912 experimental infections ciprofloxacin, 452 tobramycin, 246 endocarditis, 685 P. aeruginosa, 452 Rhinovirus pefloxacin, 685 pefloxacin, 452 4,6-dichloroflavin, 595 methicillin-resistant Polidocanol enviroxime, 102, 595 ciprofloxacin, 688 S. aureus penicillin resistance, 632 RMI-15,731, 595 penicillin-binding protein, 828 Poliovirus Ro 09-0179, 595 penicillin resistance bismuth salts, 306 Ro 09-0410, 595 suppression, 632 Polymorphonuclear leukocytes 44 081 R.P., 846 polidocanol, 632 aminoglycosides, 712 Ribavirin R plasmids prostaglandin production, 257 aerosol cloning into E. coli, 79 influenza virus, 309 Staphylococcus saprophyticus x SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.

amifloxacin, 449 BA-41,799, 146 Trypanosoma cruzi urinary tract infections, 449 Ticarcillin formycin B, 491 Streptococci comparative activity, 1 group D efficacy, 291 erythromycin resistance determinant, endocarditis, 1 U63196-E 439 P. aeruginosa, 1 see cefpimizole Tn917-like sequences, 439 safety, 291 UK-49,858 penicillin tobramycin nephrotoxicity, 897 experimental infections reverse inoculum effect, 948 Tinidazole C. albicans, 832 Streptococcus pneumoniae giardiasis, 227 T. mentagrophytes, 832 experimental infections G. lamblia, 227 Urinary catheters meningitis, 141 Tioconazole P. aeruginosa, 619 penicillin susceptibility, 141 absorption, 964 Urinary tract infections Streptomyces albovinaceous persistence in vaginal fluid, 964 amifloxacin, 449 treponemycin, 239 Tissue culture cells ceftriaxone, 158 Streptomycin erythromycin E. coli, 107, 449 mutants accumpulation, 314 norfloxacin, 297, 419 dihydrostreptose, 367 egress, 314 S. saprophyticus, 449 streptidine biosynthesis, 367 uptake, 314 tetracycline hydrochloride therapy, 652 Sulbactam Tobramycin trimethoprim-sulfamethoxazole, 158, Campylobacter spp., 429 combinations 297, 419 combined with ampicillin cancer patients, 605 anaerobic bacteria, 876 ceftazidime, 605 comparative activity, 429 clindamycin, 246 Valvular lesions Sulfamethoxazole respiratory tract infections, 246 experimental trimethoprim- nephrotoxicity, 812, 897 cefotaxime, 320 Aeromonas spp., 643 P. aeruginosa Vancomycin Campylobacter spp., 429 extracellular proteases, 468 high-pressure liquid chromatography, comparative activity, 419, 429 urinary catheters, 619 503 enterococci, 71 pharmacokinetics, 285 pharmacokinetics P. shigelloides, 643 renal accumulation, 812 continuous ambulatory peritoneal di- urinary tract infections, 158, 297, 419 renal disposition, 520 alysis, 578 V. cholerae resistance, 280 renal function peritoneal drug transport, 578 Susceptibility testing shock, 217 Ventricular fibrillation moxalactam Topical antibiotics amphotericin B infusion, 868 agar dilution, 424 mupirocin (pseudomonic acid), 495 Vesicular stomatitis virus microdilution, 424 Treponema hyodysenteriae interferon aerosol, 60 MICs, 424 treponemycin, 239 Vibrio cholerae T. vaginalis Treponemycin resistance time-kill method, 332 T. hyodysenteriae, 239 plasmid-mediated, 280 Trichomonas vaginalis trimethoprim-sulfamethoxazole, 280 bithionol, 65 Vidarabine T-1982 dichlorophene, 65 combined with acyclovir, 600 see cefbuperazone growth inhibition, 65 cytomegalovirus, 600 Talisomycin hexachlorophene, 65 E. coli DNA breakage, 460 susceptibility testing Teicoplanin time-kill method, 332 WIN 39375 experimental infections Trichophyton mentagrophvtes see amifloxacin endocarditis, 135 experimental infections WIN 51711 Temocillin UK-49,858, 832 in vitro activity, 883 bleeding times, 858 Trimethoprim picornavirus, 883 experimental infections enterococci, 71 colitis, 980 resistance platelet responsiveness, 858 chromosomally mediated, 933 Yersinia enterocolitica Tetracycline plasmid-borne, 933 P-lactams, 806 Aeromonas spp., 643 Tn7, 933 Yersinia ruckeri P. shigelloides, 643 -sulfamethoxazole plasmid-mediated resistance, 938 resistance Aeromonas spp., 643 susceptibility patterns, 938 E. coli K-12, 879 Campylobacter spp., 429 YM-13115 TnlO-mediated, 879 comparative activity, 419, 429 in vitro activity, 565 staphylococcal resistance, 234 enterococci, 71 urinary tract infections, 652 P. shigelloides, 643 Tetrahydrofuran urinary tract infections, 158, 297, 419 Zinc derivatives V. cholerae resistance, 280 C. trachomatis inhibition, 953 1985 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1913 I Street, NW * Washington, DC 20006 * (202) 833-9680 COMPLETE ALL INFORMATION REQUESTED AND RETURN FORM WITH REMITTANCE IN U.S. FUNDS Eligibility ASM welcomes to full membership anyone who is interested in its objectives and has a minimum of a bachelors de- gree or equivalent in microbiologyora related field. Initiation Memberships are initiated and renewed in January each year. Unless there are directions to the contrary, membership nominations received prior to November 1 are credited to the current year, and back issues of the selected publications for the current year are furnished, if available. Nominations received after November 1 will become effective the following January. NAME FIRST INITIAL LAST ADDRESS ClTY STATE/PROVINCE ZIP/POSTAL CODE COUNTRY PHONENUMBER( ) YEAR OF BIRTH SEX_ HIGHEST DEGREE YEAR EARNED MAJOR SUBJECT GRANTING INSTITUTION PRESENT POSITION CURRENT SCIENTIFIC AREA

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