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Front Matter ANTIMICROBIAL AGENTS AND CHEMOTHERAPY VOLUME 29 * JUNE 1986 * NUMBER 6 Robert C. Moellering, Jr., Editor in Chief (1990) George A. Jacoby, Jr., Editor (1990) New England Deaconess Hospital Massachusetts General Hospital Boston, Mass. Boston Michael Barza, Editor (1990) Christine C. Sanders, Editor (1989) New England Medical Center Hospitals Creighton University School ofMedicine Boston, Mass. Omaha, Neb. Herbert L. Ennis, Editor (1987) John A. Washington II, Editor (1986) Roche Institute ofMolecular Biology Cleveland Clinic Foundation Nutley, N.J. Cleveland, Ohio Jack M. Gwaltney, Jr., Editor (1990) Peter G. Welling, Editor (1988) University of Virginia School ofMedicine Warner-Lambert Co. Charlottesville Ann Arbor, Mich. EDITORIAL BOARD Norris Alien (1986) Gertrude B. Elion (1987) Stuart B. Levy (1986) W. Michael Scheld (1986) Vincent T. Andriole (1987) George M. Eliopoulos (1988) Joan Lusk (1986) Jerome J. Schentag (1988) Bascom F. Anthony (1988) Arthur English (1986) R. Luthy (1986) Raymond F. Schinazi (1986) George R. Aronoff (1986) Robert J. Fass (1988) Gerald L. Mandeli (1986) Fritz D. Schoenknecht (1986) Robert Austrian (1986) Stuart Feldman (1988) Gary R. Matzke (1986) F. C. Sciavolino (1988) Richard H. Baltz (1987) Sydney Finegold (1988) George H. McCracken (1987) William M. Shannon (1986) Rashmi H. Barbhaiya (1986) Robert J. Fitzgerald (1986) Antone A. Medeiros (1987) Charles Shipman, Jr. (1988) Arthur L. Barry (1986) Martin Forbes (1986) Gerald Medoff (1986) David M. Shlaes (1988) John G. Bartlett (1987) Peter T. Frame (1988) Michael Miller (1987) Robert W. Sidweil (1987) Arnold S. Bayer (1988) John N. Galgiani (1987) Thomas P. Moyer (1986) P. Frederick Sparling (1987) William M. Bennett (1987) Dale N. Gerding (1988) Barbara E. Murray (1987) Harold Standiford (1988) Richard F. Bergstrom (1988) Anthony J. Glazko (1987) John D. Nelson (1986) David A. Stevens (1986) Karen K. Biron (1987) Irving H. Goldberg (1988) Harold C. Neu (1986) Stephen E. Straus (1987) Gerald P. Bodey (1986) Thomas D. Gootz (1988) Lawrence A. Pachla (1987) R. Sutherland (1988) Arthur E. Brown (1987) Scott M. Hammer (1986) Joseph S. Pagano (1987) Morton N. Swartz (1988) Lawrence E. Bryan (1988) W. Lee Hand (1986) James E. Pennington (1986) Richard B. Sykes (1988) Ward Bullock (1987) H. Hunter Handsfield (1986) T. J. Perun (1986) Francis P. Taly (1987) Tsun Chang (1986) Frederick G. Hayden (1987) Lance R. Peterson (1988) Fred C. Tenover (1988) Anthony Chow (1988) Michael Higgins (1986) Michael Rein (1986) Alexander Tomasz (1988) C. Glenn Cobbs (1986) David C. Hooper (1987) W. H. G. Richards (1986) Roger D. Toothaker (1988) Paul S. Cohen (1986) Richard Hornick (1986) Richard Roberts (1988) Francis L. S. Tse (1986) William A. Craig (1987) George Gee Jackson (1986) Ian M. RoUo (1988) Richard J. Wallace, Jr. (1987) Naomi Datta (1987) James H. Jorgensen (1987) Allan Ronald (1987) Michael Waring (1987) Lawrence E. Day (1986) William J. Jusko (1986) Richard Root (1986) Bernard Weisblum (1988) William E. Dismukes (1987) A. W. Karchmer (1988) John P. Rosazza (1986) Richard M. Welch (1986) R. Gordon Douglas, Jr. (1986) Donald Kaye (1988) Jon E. Rosenblatt (1988) Richard Wise (1986) John C. Drach (1987) George S. Kobayashi (1988) Robert H. Rubin (1987) John S. Wolfson (1987) George L. Drusano (1987) Donald J. Krogstad (1986) Merle Sande (1988) Loweli Young (1988) Theodore Eickhoff (1988) Felix Leltner (1986) W. Eugene Sanders, Jr. (1987) Pauline K. W. Yu (1988) Stephen A. Lerner (1986) Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director ofPublications Linda M. Illig, Managing Editor, Journals Carol J. Neff, Production Editor Antimicrobial Agents and Chemotherapy (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic, and anticancer agents and chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. Antimicrobial Agents and Chemotherapy is published monthly, and the twelve numbers are divided into two volumes per year. The nonmember subscription price is $180 per year; single copies are $21. The member subscription price is $35 (foreign, $49 [surface rate]) per year; single copies are $7. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Antimicrobial Agents and Chemotherapy, ASM, 1913 I St., NW, Washington, DC 20006. Made in the United States of America. Copyright © 1986, American Society for Microbiology. E : 19¢z jA,j' IP f* 4: 4 1IO All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index Agnelli, Giancarlo, 1108 Gouby, Anne, 1095 Lynch, William H., 992 Sandhu, Nihal, 1088 Alvarez, Maria, 972 Grosse, F., 1073 Schomburg, U., 1073 Andremont, Antoine, 1047, Guerciolini, Roberto, 1108 Maass, G., 1073 Shigeta, Shiro, 1053 1104 Gurwith, Dorothy, 969 MacCoss, Malcolm, 1025 Shlaes, David M., 980 Andrews, J. M., 1067 Gurwith, Marc, 969 Marois, Yves, 1005 Simberkoff, Michael S., 1098 Aoyama, Hiroshi, 1059 Martin, N. L., 1079 Stein, Gary E., %9 Aronoff, Stephen C., 980 Hafiz, Saleem, 1110 McCashion, Ruth N., 992 Suzue, Seigo, 1059 Heymans, C., 997 McGuire, John L., 986 Sy, Ernesto R., 1088 Bergeron, Michel G., 1005 Hirai, Keiji, 1059 Meunier, F., 997 Bergeron, Yves, 1005 Ho, Dah Hsi, 972 Mitani, Masayoshi, 1017 Tan, James S., 965 Beveridge, T. J., 1079 Hosaka, Masaki, 1059 Morgan, Donna R., 1040 Tanayama, Shigeharu, 1017 Bodey, G. P., 972 Howell, Anne W., 1090 Mori, Syuichi, 1053 Tancrede, Cyrille, 1047, 1104 Borgers, Marcel, 986 Hoy, Jennifer F., 972 Mummaw, Nancy, 969 Thirolf, Patricia, 972 Bostedor, Richard, 1025 Huang, Alice S., 1010 Tolman, Edward L., 986 Bourg, Gisele, 1095 Hussy, P., 1073 Naeshiro, Ichiro, 1017 Tolman, Richard L., 1025 Buys, Leo F. M., 1032 Nenci, Giuseppe G., 1108 Toltzis, Philip, 1010 Irikura, Tsutomu, 1059 Niwata, Yasushi, 1059 Torii, Hiroshi, 1017 Ceuppens, A. M., 997 Isaacson, David M., 986 Tummler, B., 1073 Colon-Lucca, Hector, 1088 Ofosu, Fred, 1108 Condon, Robert E., 1101 Jacobs, Michael R., 980 Oomori, Yasuo, 1059 Van Cutsem, Jan, 986 Johenning, Sharon, 980 van den Barselaar, Maria T., deCastro, Aurora F., 961 Johnson, Philip C., 1040 Parise, Pasquale, 1108 1032 de Clercq, Erik, 1053 Jones, Brian M., 1110 Pasticci, Bruna, 1108 Van den Bossche, Hugo, 986 Del Favero, Albano, 1108 Jorgensen, James H., 1090 Patel, Chittaranjan, 961 van den Broek, Pieter J., 1032 Duerden, Brian I., 1110 Pecquet, Sophie, 1047 Van der Auwera, P., 997 DuPont, Herbert L., 1040 Karkas, John D., 1025 Piddock, L. J. V., 1067 van Furth, Ralph, 1032 Keith, Barry R., 1092 Place, Janet Dobbins, 961 Edmiston, Charles E., 1101 Knick, Victoria B., 1092 Wagner, Arthur F., 1025 Elwell, Lynn P., 1092 Konno, Kenji, 1053 Rahal, James J., Jr., 1098 Rallos, Tesie, 1088 Wagner, Douglas S., 965 Ericsson, Charles D., 1040 Wilson, H. Robert, 1092 Ernst, Jerome A., 1088 Lam, Charles T., 961 Ramuz, Michel, 1095 1032 Redding, Judith S., 1090 Wise, R., 1067 Leijh, Peter C. J., 992 Field, A. Kirk, 1025 Levinson, Benjamin, 1101 Rolston, K. V. I., 972 Wood, Stephen C., File, Thomas M., 965 Lim, J. M., 977 Rosenthale, Marvin E., 986 Friedhoff, Lawrence T., 1101 Lin, C. C., 977 Yamabe, Shigeru, 980 Liou, Richard, 1025 Salstrom, Sara-Jane, 965 Yokota, Tomoyuki, 1053 Germershausen, John, 1025 Lorian, Victor, 1088 Sancho-Garnier, Helene, 1104 Yoshida, Kiyoshi, 1017 ANNUAL MEETING CASSETTES Cassettes of the annual meeting sessions are now available for purchase from AVW Audio Visual, Inc. Here's how the annual meeting cassettes can be valuable long after the American Society for Microbiology meeting is over: * Provides an excellent 'refresher course' for the future. * Provides an invaluable educational and training tool. * Provides access to important information for those unable to attend. Get your AVW annual meeting cassettes by using the handy orderform below. American Society for Microbiology March 22-28, 1986 Washington, D.C. SATURDAY, MARCH 22, 1986 ASM WORKSHOP "A": RAPID TESTING FOR INFECTIOUS DISEASES c/o AVW Audio Visual, Inc. ASM-WAl Rapid Detection of Bacteremias & Respiratory Infections .$8.00 ASM-WA2 Rapid Detection of Urinary Tract Infections ......$...........S 8.00 2254 Valdina Street, Suite 100 ASM-WA3 Rapid Detection of Genital Infections .$................ ..... .S8.00 ASM-WA4 Rapid Detection of Diarrheal Diseases .... S 8.00 Dallas, Texas 75207 ASM-WA5 Role of Rapid Detection in the Diagnosis of Infectious Diseases ..... $8.00 SPECIAL: WORKSHOP "A' ALL TAPES IN BINDER $32.00 214/638-0024 WORKSHOP "B": CLINICAL APPLICATINOS OF DNA PROBES ASM-WB1 Role of DNA Probes in the Clinical Laboratory: An Overview ....$..
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