Research Report of the Medical Faculty 2015
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Research Report of the Medical Faculty 2015 Reference Period 2013 - 2014 General Aspects Content General Aspects_______________________________________________________________________________ 3 Preclinical Institutions Institute of Anatomy and Cell Biology_____________________________________________________________ 12 Institute of Molecular Biology and Tumorbiology (IMT)_______________________________________________ 17 Institute of Physiological Chemistry_______________________________________________________________23 Institute of Physiology and Pathophysiology________________________________________________________25 Department of Medical Psychology_______________________________________________________________31 Institute of Medical Sociology and Social Medicine___________________________________________________34 Clinical-theoretical Institution Institute of General and Family Medicine, Prevention and Rehabilitations________________________________ 36 Institute of Medical Biometry and Epidemiology____________________________________________________ 39 Institute of Pharmacology and Toxicology__________________________________________________________41 Emil-von-Behring-Library, Department of the History of Medicine______________________________________ 44 Institute of Clinical Cytobiology and Cytopathology__________________________________________________ 46 Institute of Immunology________________________________________________________________________49 Institute of Medical Microbiology and Hospital Hygiene______________________________________________ 51 Institute of Virology___________________________________________________________________________ 54 Centre for Human Genetics_____________________________________________________________________ 61 Institute of Pathology__________________________________________________________________________62 Division of Neuropathology_____________________________________________________________________ 64 Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics___________________________66 Institute for Lung Research _____________________________________________________________________69 Clinical Institutions Department of Anaesthesia and Intensive Care Therapy______________________________________________ 73 Department of Diagnostic and Interventional Radiology_____________________________________________75 Department of Nuclear Medicine________________________________________________________________ 78 Department of Radiotherapy and Radiooncology____________________________________________________81 Department of Internal Medicine: Division of Gastroenterology, Endocrinology and Metabolism______________84 Department of Internal Medicine: Division of Hematology, Oncology and Immunology______________________89 Department of Internal Medicine: Division of Cardiology______________________________________________95 Department of Internal Medicine: Division of Pneumology____________________________________________ 97 Department of Internal Medicine: Division of Psychosomatic Medicine and Psychotherapy_________________ 101 Department of Cardiovascular Surgery___________________________________________________________ 103 Department of Neurosurgery___________________________________________________________________105 Department of Orthopaedics and Rheumatology___________________________________________________ 107 Department of Trauma, Hand- and Reconstructive Surgery___________________________________________110 Department of Urology and Pediatric Urology – Prostate Cancer Centre_________________________________112 Department of Visceral-, Thoracic and Vascular Surgery_____________________________________________ 113 Department of Gynaecology, Gynaecological Endocrinology and Oncology______________________________ 115 Children’s Hospital___________________________________________________________________________ 118 Department of Otolaryngology, Head and Neck Surgery_____________________________________________ 120 Department of Ophthalmology_________________________________________________________________ 123 Departement of Dermatology and Allergology_____________________________________________________ 125 Department of Neurology_____________________________________________________________________ 130 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy ______________________136 Department of Psychiatry and Psychotherapy_____________________________________________________ 140 Department of Oral and Maxillofacial Surgery, Oral Surgery and Implantology____________________________147 Department of Orthodontics___________________________________________________________________ 151 Departement of Periodontology________________________________________________________________ 152 Department of Operative Density and Endodontics_________________________________________________ 154 Department of Pediatric and Community Density___________________________________________________156 Department of Prosthodontics and Craniomandibular Function_______________________________________ 158 Coordination Centre for Clinical Trials____________________________________________________________162 List of Abbreviations/Glossary BMBF Federal Ministry of Education and Research – Bundesministerium für Bildung und Forschung BMFZ Biomedical Research Centre – Biomedizinisches Forschungszentrum CCC Comprehensive Cancer Center DFG German Research Foundation / Deutsche Forschungsgemeinschaft FOR Research Unit / Forschergruppe GRK Research Training Group / Graduiertenkolleg IMT Institute for Molecular Biology and Tumor Research JIF Journal Impact Factor KFO Clinical Research Unit / Klinische Forschergruppe KKS Coordination Centre for Clinical Studies LOEWE State Offensive for the Development of Scientific-Economic Excellence / Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz LOF Performance-related allocation of research and office space LOM Performance-related Funding / Leistungsorientierte Mittelvergabe SFB Collaborative Research Centre / Sonderforschungsbereich SFB/TR TR Transregional Collaborate Research Centre / Transregio UKGM University Hospital Giessen and Marburg Universitätsklinikum Gießen und Marburg ZTI Centre for Tumor and Immunobiology/ Zentrum für Tumor- und Immunbiologie General Aspects General Aspects technology including proteomics, genomics, live-cell and super-resolution imaging methods. The groups Main Fields of Research also exploit pathologically altered cells to analyze According to the criteria of the German Research and compare the changes in the intracellular Council (DFG) at the School of Medicine of the compartments in order to define and distinguish Philipps University Marburg the following preferred normal and pathologically altered processes at the research clusters are established: molecular level. A unifying goal of the research groups in this area is the identification and characterization of the molecular machineries Cellular Compartimentation and Disease participating in the biogenesis, maintenance and Relevance dynamic alteration of the various compartments of a Clinical Immunology and Infection Biology eukaryotic cell. Further, the groups try to unravel the Oncology and Tumor Biology mechanisms underlying the intracellular transport of Neuroscience proteins, nucleic acids, lipids, metabolites, and metals. Associated infrastructural components already Another central focus is on the impact of (highly existent are the Biomedical Research Centre (BMFZ), pathogenic) viruses, intracellular parasites, and the Institute for Molecular Biology and Tumor fungal pathogens on intracellular Research (IMT), the Center for Tumorbiology and compartmentalization, and on the importance of Immunology (ZTI) the Comprehensive Cancer Center compartment-specific tropism for pathogen Marburg (CCC), the Carreras Leukaemia Centre and reproduction and host cell toxicity. The common the Allergy Centre Hesse. goal of these projects is the elucidation of how these pathogens alter and exploit cellular compartments to ensure their own survival. The thorough Research Cluster „Cellular Compartmentation mechanistic investigation of the molecular basis of and its Relevance for Disease“ intracellular compartmentation is a prerequisite for The location of intracellular compartments and the understanding of the disease-relevant smaller entities such as protein complexes, nucleic phenotypes and the long-term development of acids, metals and lipids within a cell is prerequisite therapeutic regimes. for the complexity and regulation of the biological functions performed by this particular cell. Failure to The research cluster has been funded by several accurately localize cellular biomolecules is frequently coordinated programs of DFG. This includes a associated with disease. In order to generate, Collaborative Research Center (SFB 593), a Graduate maintain and modulate biogenesis, composition and Research Training Group (GRK 1216), and a Research location of various intracellular compartments, Unit (FOR 1086). All these coordinate funding eukaryotic cells have developed sophisticated programs have terminated in 2015. Efforts are machineries to ensure transport of metals, currently on the way to acquire new funding metabolites, lipids, proteins, and nucleic acids across opportunities within coordinated programs. These membranes and to support membrane trafficking efforts are undertaken with partners from the within the cell. Work in the Research