viruses Review Tick-Borne Flaviviruses and the Type I Interferon Response Richard Lindqvist 1,2,3 ID , Arunkumar Upadhyay 1,2,3,† and Anna K. Överby 1,2,3,* ID 1 Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden;
[email protected] (R.L.);
[email protected] (A.U.) 2 Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-90187 Umeå, Sweden 3 Umeå Centre for Microbial Research (UCMR), Umeå University, SE-90187 Umeå, Sweden * Correspondence:
[email protected]; Tel.: +46-90-7850922 † Current address: Institut für Zytobiologie, Philipps-Universität Marburg, D-35032 Marburg, Germany. Received: 29 May 2018; Accepted: 19 June 2018; Published: 21 June 2018 Abstract: Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes. Mosquito-borne flaviviruses and their interactions with the innate immune response have been well-studied and reviewed extensively, thus this review will discuss tick-borne flaviviruses and their interactions with the host innate immune response. Keywords: tick-borne flavivirus; innate immunity; interferon; tick-borne encephalitis virus; powassan virus; omsk hemorrhagic fever virus; kyasanur forest disease virus; louping ill virus; viperin 1. Introduction Tick-borne flaviviruses (TBFV), Flaviviridae family, includes many pathogens causing severe human disease, ranging from mild fever to encephalitis and hemorrhagic fever. There are more than 70 viruses in the genus flavivirus, and they are transmitted by arthropods such as mosquitoes (dengue virus (DENV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), yellow fever virus (YFV), and Zika virus (ZIKV) and ticks (tick-borne encephalitis virus (TBEV), Langat virus (LGTV), Kyasanur forest disease virus (KFDV), Omsk hemorrhagic fever virus (OHFV), Powassan virus (POWV), and Louping-ill virus (LIV)) [1–5].