Table of Contents (PDF)

July 13, 2021 u vol. 118 u no. 28

From the Cover

e2105245118 Blood–brain barrier and nanomaterials e2023757118 Seismic observation of subglacial water flow e2024802118 Post‐Columbian epidemics in California e2024448118 Cortex reorganization during adolescence e2101458118 Climate change and dragonfly ornamentation

Contents

THIS WEEK IN PNAS—This week’s research highlights eiti2821118 In This Issue Cover image: Pictured is an illustration of metallic nanomaterials crossing the blood–brain barrier. Using a model of PROFILE—The life and work of NAS members human cell cultures, Zhiling Guo et al. e2110547118 Profile of Claude Desplan found that the shape, size, and Jennifer Viegas intrinsic solubility of various metallic See Inaugural Article, e2101823118, in vol. 118, issue 28 nanomaterials influence their biotransformation, which modulates their transport form, efficiency, and COMMENTARIES pathways through the blood–brain barrier and subsequent neurotoxicity. e2109434118 How to train your bacteriophage The findings could aid predictions of the Adair L. Borges nanomaterials’ neurotoxicity and inspire See companion article, e2104592118, in vol. 118, issue 23 designs for safe nanomaterials for e2108946118 Antipsychotics, versatility in action biomedical applications. See the article Sidharth Mahapatra and Tiago Reis Marques by Guo et al., e2105245118. Image See companion article, e2020078118, in vol. 118, issue 24 credit: Zhiling Guo. e2109436118 Shining light on photosynthetic microbes and manganese-enriched rock varnish Valeria C. Culotta and Asia S. Wildeman See companion article, e2025188118, in vol. 118, issue 25 e2109992118 A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase Tzu-Yu Chen and Wei-chen Chang See companion article, e2026742118, in vol. 118, issue 26

PERSPECTIVE e2022666118 Novel technologies for emission reduction complement conservation agriculture to achieve negative emissions from row-crop production Daniel L. Northrup, Bruno Basso, Michael Q. Wang, Cristine L. S. Morgan, and Philip N. Benfey

LETTERS e2107784118 Do positive allosteric modulators (PAMs) of the MOR exert antinociception with reduced side effects under pathological conditions? Tao Zhuang, Yurong Ma, and Guisen Zhang

Free online through the PNAS open access option. PNAS u July 13, 2021 u vol. 118 u no. 28 u iii–viii Downloaded by guest on September 27, 2021 e2108493118 Reply to Zhuang et al.: Potential side effects e2024961118 Modeling links softening of myelin and spectrin of positive allosteric modulators of the scaffolds of axons after a concussion to increased mu-opioid receptor vulnerability to repeated injuries John R. Traynor Aayush Kant, Victoria E. Johnson, John D. Arena, e2108608118 Still no evidence for transgenerational Jean-Pierre Dolle´, Douglas H. Smith, and Vivek B. Shenoy inheritance or absence of epigenetic reprogramming in the honey bee CHEMISTRY Fernando G. Soley e2103513118 Identification of simple arylfluorosulfates e2109211118 Reply to Soley: DNA methylation marks are as potent agents against stably transferred across generations in resistant bacteria honey bees Jiong Zhang, Xiangxiang Zhao, John R. Cappiello, Yi Boris Yagound, Emily J. Remnant, Gabriele Buchmann, Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu and Benjamin P. Oldroyd Luo, Yu Zhang, Jiajia Dong, Lixin Zhang, and K. Barry Sharpless e2025440118 Reply to Linton: Perspectival interference up close e2108881118 1,2-Difunctionalized bicyclo[1.1.1]pentanes: – Jorge Morales, Axel Bax, and Chaz Firestone Long sought-after mimetics for ortho/ meta-substituted arenes Jin-Xin Zhao, Yu-Xuan Chang, Chi He, Benjamin J. INAUGURAL ARTICLE Burke, Michael R. Collins, Matthew Del Bel, Jeff Elleraas, Gary M. Gallego, T. Patrick Montgomery, James J. e2101823118 Neural specification, targeting, and circuit Mousseau, Sajiv K. Nair, Matthew A. Perry, Jillian E. formation during visual system assembly Spangler, Julien C. Vantourout, and Phil S. Baran Jennifer Malin and Claude Desplan e2104411118 Rapid diagnosis and tumor margin See Profile Article, e2110547118, in vol. 118, issue 28 assessment during pancreatic cancer surgery with the MasSpec Pen technology BRIEF REPORT Mary E. King, Jialing Zhang, John Q. Lin, Kyana Y. e2107483118 The intersection of DNA replication with Garza, Rachel J. DeHoog, Clara L. Feider, antisense 3′ RNA processing in Arabidopsis Alena Bensussan, Marta Sans, Anna Krieger, FLC chromatin silencing Sunil Badal, Michael F. Keating, Spencer Woody, Sadhna Dhingra, Wendong Yu, Colette L. Baxter, Sasa Svikovic, Julian E. Sale, Christopher Pirko, Kirtan A. Brahmbhatt, George Caroline Dean, and Silvia Costa Van Buren, William E. Fisher, James Suliburk, and Livia S. Eberlin

PHYSICAL SCIENCES EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES e2023757118 Observing the subglacial hydrology network APPLIED MATHEMATICS and its dynamics with a dense seismic array e2015851118 Tensor-tensor algebra for optimal Ugo Nanni, Florent Gimbert, Philippe Roux, representation and compression and Albanne Lecointre of multiway data Misha E. Kilmer, Lior Horesh, Haim Avron, ENGINEERING and Elizabeth Newman e2024961118 Modeling links softening of myelin and spectrin scaffolds of axons after a concussion to increased APPLIED PHYSICAL SCIENCES vulnerability to repeated injuries e2100145118 An effective and efficient model of the Aayush Kant, Victoria E. Johnson, John D. Arena, near-field hydrodynamic interactions for Jean-Pierre Dolle´, Douglas H. Smith, active suspensions of bacteria and Vivek B. Shenoy Bokai Zhang, Premkumar Leishangthem, Yang e2100772118 A self-powered implantable and bioresorbable Ding (丁阳), and Xinliang Xu electrostimulation device for biofeedback e2105245118 Biotransformation modulates the penetration bone fracture healing of metallic nanomaterials across an artificial Guang Yao, Lei Kang, Cuicui Li, Sihong Chen, blood–brain barrier model Qian Wang, Junzhe Yang, Yin Long, Jun Li, Kangning Zhao, Weina Xu, Weibo Cai, Yuan Lin, Zhiling Guo, Peng Zhang, Swaroop Chakraborty, and Xudong Wang Andrew J Chetwynd, Fazel Abdolahpur Monikh, Christopher Stark, Hanene Ali-Boucetta, Sandra e2103457118 Hydrogel–mesh composite for wound closure Wilson, Iseult Lynch, and Eugenia Valsami-Jones Yang Gao, Xiuyuan Han, Jiaojiao Chen, Yudong Pan, e2106380118 Entropic barrier of topologically immobilized Meng Yang, Linhe Lu, Jian Yang, Zhigang Suo, and Tongqing Lu DNA in hydrogels Kuo Chen and Murugappan Muthukumar ENVIRONMENTAL SCIENCES e2026378118 Birds use individually consistent temperature BIOPHYSICS AND COMPUTATIONAL BIOLOGY cues to time their migration departure e2101144118 Quantification and demonstration of the Robert J. Burnside, Daniel Salliss, Nigel J. Collar, collective constriction-by-ratchet mechanism and Paul M. Dolman in the dynamin molecular motor MATHEMATICS Oleg M. Ganichkin, Renee Vancraenenbroeck, Gabriel Rosenblum, Hagen Hofmann, Alexander S. Mikhailov, e2107069118 From linear to metric functional analysis Oliver Daumke, and Jeffrey K. Noel Anders Karlsson

iv u www.pnas.org Contents Downloaded by guest on September 27, 2021 PHYSICS BIOLOGICAL SCIENCES e2108938118 Pressure-induced high-temperature superconductivity retained without APPLIED BIOLOGICAL SCIENCES pressure in FeSe single crystals e2100772118 A self-powered implantable and bioresorbable Liangzi Deng, Trevor Bontke, Rabin Dahal, Yu Xie, Bin electrostimulation device for biofeedback Gao, Xue Li, Ketao Yin, Melissa Gooch, Donald bone fracture healing Rolston, Tong Chen, Zheng Wu, Yanming Ma, Guang Yao, Lei Kang, Cuicui Li, Sihong Chen, Pengcheng Dai, and Ching-Wu Chu Qian Wang, Junzhe Yang, Yin Long, Jun Li, Kangning Zhao, Weina Xu, Weibo Cai, Yuan Lin, SUSTAINABILITY SCIENCE and Xudong Wang e2024912118 Integrated assessment modeling reveals near- e2100561118 DNAse-dependent, NET-independent channel management as cost-effective pathway of thrombus formation in vivo to improve water quality in Estelle Carminita, Lydie Crescence, Nicolas Brouilly, agricultural watersheds Alexandre Altie´, Laurence Panicot-Dubois, Amy T. Hansen, Todd Campbell, Se Jong Cho, and Christophe Dubois Jonathon A. Czuba, Brent J. Dalzell, Christine L. Dolph, Peter L. Hawthorne, Sergey Rabotyagov, Zhengxin Lang, Karthik Kumarasamy, Patrick Belmont, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Jacques C. Finlay, Efi Foufoula-Georgiou, Karen B. e2101144118 Quantification and demonstration of the Gran, Catherine L. Kling, and Peter Wilcock collective constriction-by-ratchet mechanism in the dynamin molecular motor Oleg M. Ganichkin, Renee Vancraenenbroeck, Gabriel SOCIAL SCIENCES Rosenblum, Hagen Hofmann, Alexander S. Mikhailov, ANTHROPOLOGY Oliver Daumke, and Jeffrey K. Noel e2024802118 Historic and bioarchaeological evidence e2102285118 Regulation and drug modulation of a voltage- supports late onset of post-Columbian gated sodium channel: Pivotal role of epidemics in Native California the S4–S5 linker in activation and Terry L. Jones, Al W. Schwitalla, Marin A. Pilloud, slow inactivation John R. Johnson, Richard R. Paine, Jinglei Xiao, Vasyl Bondarenko, Yali Wang, Antonio and Brian F. Codding Suma, Marta Wells, Qiang Chen, Tommy Tillman, Yan Luo, Buwei Yu, William P. Dailey, Roderic ECONOMIC SCIENCES Eckenhoff, Pei Tang, Vincenzo Carnevale, e2101160118 Thirty-five years later: Long-term effects of Michael L. Klein, and Yan Xu the Matlab maternal and child health/family ’ planning program on older women s CELL BIOLOGY well-being e2019822118 p53 deficiency induces MTHFD2 transcription Tania Barham, Brachel Champion, Andrew D. Foster, to promote cell proliferation and restrain Jena D. Hamadani, Warren C. Jochem, Gisella Kagy, Randall Kuhn, Jane Menken, Abdur Razzaque, DNA damage Elisabeth Dowling Root, and Patrick S. Turner Gen Li, Jun Wu, Le Li, and Peng Jiang e2024596118 The GAS6-AXL signaling pathway triggers PSYCHOLOGICAL AND COGNITIVE SCIENCES actin remodeling that drives membrane e2024448118 Shifting gradients of macroscale cortical ruffling, macropinocytosis, and cancer- organization mark the transition from cell invasion childhood to adolescence Daria Zdzalik-Bielecka,_ Agata Poswiata, Kamila Kozik, x Hao-Ming Dong (董昊铭), Daniel S. Margulies, Xi-Nian Kamil Jastrzebski, Kay Oliver Schink, Marta Brewinska- Zuo (左西年), and Avram J. Holmes Olchowik, Katarzyna Piwocka, Harald Stenmark, and Marta Miaxczynska SOCIAL SCIENCES e2026421118 Sufu negatively regulates both initiations e2101160118 Thirty-five years later: Long-term effects of of centrosome duplication and the Matlab maternal and child health/family DNA replication planning program on older women’s Tenghan Zhuang, Boyan Zhang, Yihong Song, well-being Fan Huang, Wangfei Chi, Guangwei Xin, Ziyu Zhang, Steven Y. Cheng, Qing Jiang, Tania Barham, Brachel Champion, Andrew D. Foster, and Chuanmao Zhang Jena D. Hamadani, Warren C. Jochem, Gisella Kagy, Randall Kuhn, Jane Menken, Abdur Razzaque, Elisabeth Dowling Root, and Patrick S. Turner DEVELOPMENTAL BIOLOGY e2101823118 Neural specification, targeting, and circuit SUSTAINABILITY SCIENCE formation during visual system assembly e2024912118 Integrated assessment modeling reveals near- Jennifer Malin and Claude Desplan channel management as cost-effective See Profile Article, e2110547118, in vol. 118, issue 28 to improve water quality in agricultural watersheds e2102562118 Ciliopathy genes are required for apical Amy T. Hansen, Todd Campbell, Se Jong Cho, secretion of Cochlin, an otolith Jonathon A. Czuba, Brent J. Dalzell, Christine L. Dolph, crystallization factor Peter L. Hawthorne, Sergey Rabotyagov, Zhengxin Eleni Leventea, Zhou Zhu, Xiaoming Fang, Lang, Karthik Kumarasamy, Patrick Belmont, Yulia Nikolaeva, Eleanor Markham, Robert Jacques C. Finlay, Efi Foufoula-Georgiou, Karen B. A. Hirst, Fredericus J. M. van Eeden, Gran, Catherine L. Kling, and Peter Wilcock and Jarema J. Malicki

Contents PNAS u July 13, 2021 u vol. 118 u no. 28 u v Downloaded by guest on September 27, 2021 e2025795118 Live imaging of remyelination in the adult IMMUNOLOGY AND INFLAMMATION mouse corpus callosum e2101169118 Landscape of innate lymphoid cells in Sara Bottes and Sebastian Jessberger human head and neck cancer reveals ECOLOGY divergent NK cell states in the tumor microenvironment e2026378118 Birds use individually consistent temperature Uriel Y. Moreno-Nieves, Joshua K. Tay, Saumyaa cues to time their migration departure Saumyaa, Nina B. Horowitz, June Ho Shin, Imran A. Robert J. Burnside, Daniel Salliss, Nigel J. Collar, Mohammad, Bogdan Luca, David C. Mundy, and Paul M. Dolman Gunsagar S. Gulati, Nikita Bedi, Serena Chang, e2024150118 Ecology of the Anthropocene signals hope for Chen Chen, Michael J. Kaplan, Eben L. consciously managing the planetary ecosystem Rosenthal, F. Christopher Holsinger, Vasu Divi, Fred M. Baik, Davud B. Sirjani, Andrew J. Clarence Lehman, Shelby Loberg, Michael Wilson, Gentles, Aaron M. Newman, Aharon G. Freud, and Eville Gorham and John B. Sunwoo e2023718118 Negative effects of nitrogen override positive e2021798118 HIPK2 phosphorylates HDAC3 for effects of phosphorus on grassland NF-κB acetylation to ameliorate colitis- legumes worldwide associated colorectal carcinoma Pedro M. Tognetti, Suzanne M. Prober, Selene Ba´ez, Enrique J. Chaneton, Jennifer Firn, Anita C. Risch, and sepsis Martin Schuetz, Anna K. Simonsen, Laura Yahdjian, Fang Zhang, Linlin Qi, Qiuyun Feng, Baokai Zhang, Elizabeth T. Borer, Eric W. Seabloom, Carlos Alberto Xiangyue Li, Chang Liu, Weiyun Li, Qiaojie Liu, Dan Arnillas, Jonathan D. Bakker, Cynthia S. Brown, Marc W. Yang, Yue Yin, Chao Peng, Han Wu, Zhao-Hui Tang, Xi Cadotte, Maria C. Caldeira, Pedro Daleo, John M. Zhou, Zou Xiang, Zhijiang Zhang, Hongyan Wang, Dwyer, Philip A. Fay, Laureano A. Gherardi, Nicole and Bin Wei Hagenah, Yann Hautier, Kimberly J. Komatsu, Rebecca e2022091118 Hypoimmune induced pluripotent stem L.McCulley,JodiN.Price,RachelJ.Standish,CarlyJ. cell–derived cell therapeutics treat Stevens, Peter D. Wragg, and Mahesh Sankaran cardiovascular and pulmonary e2024994118 Heterogeneous selection on exploration diseases in immunocompetent behavior within and among West European allogeneic mice populations of a passerine bird Tobias Deuse, Grigol Tediashvili, Xiaomeng Hu, Alexia Mouchet, Ella F. Cole, Erik Matthysen, Marion Nicolaus, Alessia Gravina, Annika Tamenang, Dong Wang, John L. Quinn, Allison M. Roth, Joost M. Tinbergen, Kees Andrew Connolly, Christian Mueller, Ben˜at Mallavia, van Oers, Thijs van Overveld, and Niels J. Dingemanse Mark R. Looney, Malik Alawi, Lewis L. Lanier, and Sonja Schrepfer e2101325118 Direct evidence of a prey depletion “halo” surrounding a pelagic predator colony e2101189118 RIPK1 activates distinct gasdermins in Sam B. Weber, Andrew J. Richardson, Judith Brown, macrophages and neutrophils upon Mark Bolton, Bethany L. Clark, Brendan J. Godley, Eliza pathogen blockade of innate Leat, Steffen Oppel, Laura Shearer, Karline E. R. immune signaling Soetaert, Nicola Weber, and Annette C. Broderick Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. EVOLUTION Grayczyk, Charles-Antoine Assenmacher, Enrico e2101458118 Sex-specific ornament evolution is Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, a consistent feature of climatic adaptation Fabienne Tacchini-Cottier, Igor E. Brodsky, across space and time in dragonflies and Petr Broz Michael P. Moore, Kaitlyn Hersch, Chanont Sricharoen, Sarah Lee, Caitlin Reice, Paul Rice, Sophie Kronick, Kim A. Medley, and Kasey D. Fowler-Finn MEDICAL SCIENCES GENETICS e2103457118 Hydrogel–mesh composite for wound closure e2026403118 A platform utilizing Drosophila ovulation for Yang Gao, Xiuyuan Han, Jiaojiao Chen, Yudong Pan, nonhormonal contraceptive screening Meng Yang, Linhe Lu, Jian Yang, Zhigang Suo, Kewa Jiang, Jiyang Zhang, Yuping Huang, Yingzheng and Tongqing Lu Wang, Shuo Xiao, M. Kyle Hadden, Teresa K. e2104411118 Rapid diagnosis and tumor margin Woodruff, and Jianjun Sun assessment during pancreatic e2106786118 Thousands of induced germline mutations cancer surgery with the MasSpec affecting immune cells identified by automated Pen technology meiotic mapping coupled with machine learning Mary E. King, Jialing Zhang, John Q. Lin, Kyana Y. Darui Xu, Stephen Lyon, Chun Hui Bu, Sara Hildebrand, Garza, Rachel J. DeHoog, Clara L. Feider, Jin Huk Choi, Xue Zhong, Aijie Liu, Emre E. Turer, Zhao Alena Bensussan, Marta Sans, Anna Krieger, Zhang, Jamie Russell, Sara Ludwig, Elena Mahrt, Evan Sunil Badal, Michael F. Keating, Spencer Nair-Gill, Hexin Shi, Ying Wang, Duanwu Zhang, Tao Woody, Sadhna Dhingra, Wendong Yu, Yue, Kuan-wen Wang, Jeffrey A. SoRelle, Lijing Su, Christopher Pirko, Kirtan A. Brahmbhatt, George Takuma Misawa, William McAlpine, Lei Sun, Jianhui Van Buren, William E. Fisher, James Suliburk, Wang, Xiaoming Zhan, Mihwa Choi, Roxana Farokhnia, and Livia S. Eberlin Andrew Sakla, Sara Schneider, Hannah Coco, Gabrielle Coolbaugh, Braden Hayse, Sara Mazal, Dawson Medler, e2013164118 Large age shifts in HIV-1 incidence Brandon Nguyen, Edward Rodriguez, Andrew Wadley, patterns in KwaZulu-Natal, Miao Tang, Xiaohong Li, Priscilla Anderton, Katie Keller, South Africa Amanda Press, Lindsay Scott, Jiexia Quan, Sydney Adam Akullian, Alain Vandormael, Joel C. Miller, Anna Cooper, Tiffany Collie, Baifang Qin, Jennifer Cardin, Rochelle Bershteyn, Edward Wenger, Diego Cuadros, Dickman Simpson, Meron Tadesse, Qihua Sun, Carol A. Wise, Gareta, Till Ba¨rnighausen, Kobus Herbst, Jonathan J. Rios, Eva Marie Y. Moresco, and Bruce Beutler and Frank Tanser

vi u www.pnas.org Contents Downloaded by guest on September 27, 2021 e2104242118 A conserved epitope III on hepatitis C NEUROSCIENCE virus E2 protein has alternate e2024448118 Shifting gradients of macroscale cortical conformations facilitating cell binding organization mark the transition from or virus neutralization childhood to adolescence Lu Deng, Nancy Hernandez, Lilin Zhong, Hao-Ming Dong (董昊铭), Daniel S. Margulies, Xi-Nian DavidD.Holcomb,HailingYan,Maria Zuo (左西年), and Avram J. Holmes Luisa Virata, Sreya Tarafdar, Yanqun Xu, Yong He, Evi Struble, Harvey J. Alter, e2102549118 Skin sodium is increased in male patients and Pei Zhang with multiple sclerosis and related animal models e2026664118 Pan-African evolution of within- Konstantin Huhn, Peter Linz, Franziska Pemsel, and between-country Bernhard Michalke, Stefan Seyferth, Christoph COVID-19 dynamics Kopp, Mohammad Anwar Chaudri, Veit Paddy Ssentongo, Claudio Fronterre, Rothhammer, Arnd Do¨ rfler, Michael Uder, Armin M. Andrew Geronimo, Steven J. Greybush, Nagel, Dominik N. Mu¨ller, Anne Waschbisch, De- Pamela K. Mbabazi, Joseph Muvawala, Hyung Lee, Tobias Ba¨uerle, Ralf A. Linker, Sarah B. Nahalamba, Philip O. Omadi, and Stefanie Haase Bernard T. Opar, Shamim A. Sinnar, Yan Wang, Andrew J. Whalen, e2101207118 PIEZO2 mediates ultrasonic hearing via Leonhard Held, Christopher Jewell, cochlear outer hair cells in mice AbrahamJ.B.Muwanguzi,Helen Jie Li, Shuang Liu, Chenmeng Song, Qun Hu, Greatrex, Michael M. Norton, Peter J. Zhikai Zhao, Tuantuan Deng, Yi Wang, Diggle, and Steven J. Schiff Tong Zhu, Linzhi Zou, Shufeng Wang, Jiaofeng Chen, Lian Liu, Hanqing Hou, Kexin Yuan, Hairong Zheng, Zhiyong Liu, Xiaowei Chen, Wenzhi Sun, Bailong Xiao, MICROBIOLOGY and Wei Xiong e2103513118 Identification of simple arylfluorosulfates e2107585118 MAGUKs are essential, but redundant, in as potent agents against long-term potentiation resistant bacteria Xiumin Chen, Yuko Fukata, Masaki Fukata, Jiong Zhang, Xiangxiang Zhao, John R. Cappiello, Yi and Roger A. Nicoll Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu Luo, Yu Zhang, Jiajia Dong, Lixin Zhang, e2105732118 Pain and itch processing by subpopulations of and K. Barry Sharpless molecularly diverse spinal and trigeminal projection neurons e2026207118 Immunogenicity and efficacy of the COVID-19 Racheli Wercberger, Joao M. Braz, Jarret A. Weinrich, candidate vector vaccine MVA-SARS-2-S in and Allan I. Basbaum preclinical vaccination e2103505118 VLM catecholaminergic neurons control tumor Alina Tscherne, Jan Hendrik Schwarz, Cornelius + Rohde, Alexandra Kupke, Georgia Kalodimou, growth by regulating CD8 T cells Leonard Limpinsel, Nisreen M. A. Okba, Ze Zhang, Yehua Li, Xueyuan Lv, Linlin Zhao, Berislav Bosnjak, Inga Sandrock, Ivan Odak, and Xiaodong Wang Sandro Halwe, Lucie Sauerhering, Katrin e2106621118 Separation of presynaptic Cav2 and Cav1 Brosinski, Nan Liangliang, Elke Duell, Sylvia channel function in synaptic vesicle exo- and Jany, Astrid Freudenstein, Jo¨rg Schmidt, endocytosis by the membrane anchored Anke Werner, Michelle Gellhorn Serra, 2+ Michael Klu¨ver, Wolfgang Guggemos, Ca pump PMCA Michael Seilmaier, Clemens-Martin Niklas Krick, Stefanie Ryglewski, Aylin Pichler, Arthur Wendtner, Reinhold Fo¨rster, Bikbaev, Torsten Go¨tz, Oliver Kobler, Martin Heine, Bart L. Haagmans, Stephan Becker, Gerd Ulrich Thomas, and Carsten Duch Sutter, and Asisa Volz e2019756118 Clock proteins regulate spatiotemporal e2105370118 Let-7b-5p in vesicles secreted by human organization of clock genes to control airway cells reduces biofilm formation circadian rhythms and increases antibiotic sensitivity of Yangbo Xiao, Ye Yuan, Mariana Jimenez, Neeraj Soni, P. aeruginosa and Swathi Yadlapalli Katja Koeppen, Amanda Nymon, Roxanna Barnaby, e1920834118 Agonist of growth hormone–releasing Laura Bashor, Zhongyou Li, Thomas H. hormone enhances retinal ganglion cell Hampton, Amanda E. Liefeld, Fred W. Kolling, protection induced by macrophages Ian S. LaCroix, Scott A. Gerber, Deborah A. after optic nerve injury Hogan, Swetha Kasetty, Carey D. Nadell, Ling-Ping Cen, Tsz Kin Ng, Jia-Jian Liang, Ciyan Xu, Xi and Bruce A. Stanton Zhuang, Yu-Fen Liu, Shao-Lang Chen, Yanxuan Xu, e2102786118 Defensive hypervariable regions Qichen Yang, Xiang-Ling Yuan, Yong Jie Qin, Sun On confer superinfection exclusion Chan, Haoyu Chen, Mingzhi Zhang, Andrew V. in microviruses Schally, and Chi Pui Pang Paul C. Kirchberger, Zachary A. Martinez, Landry J. Luker, and Howard Ochman e2018297118 Temporal compartmentalization of viral PHARMACOLOGY infection in bacterial cells e2100171118 Proton-gated coincidence detection Audrey Labarde, Lina Jakutyte, Cyrille is a common feature of Billaudeau, Beatrix Fauler, Maria Lo´pez-Sanz, GPCR signaling Prishila Ponien, Eric Jacquet, Thorsten Nicholas J. Kapolka, Jacob B. Rowe, Geoffrey J. Mielke, Silvia Ayora, Rut Carballido-Lo´pez, Taghon, William M. Morgan, Corin R. O’Shea, and Paulo Tavares and Daniel G. Isom

Contents PNAS u July 13, 2021 u vol. 118 u no. 28 u vii Downloaded by guest on September 27, 2021 PHYSIOLOGY e2023718118 Negative effects of nitrogen override positive e2022960118 Prednisolone rescues Duchenne muscular effects of phosphorus on grassland dystrophy phenotypes in human pluripotent legumes worldwide stem cell–derived skeletal muscle in vitro Pedro M. Tognetti, Suzanne M. Prober, Selene Ba´ez, Ziad Al Tanoury, John F. Zimmerman, Jyoti Rao, Daniel Enrique J. Chaneton, Jennifer Firn, Anita C. Risch, Sieiro, Harold M. McNamara, Thomas Cherrier, Martin Schuetz, Anna K. Simonsen, Laura Yahdjian, Alejandra Rodrı´guez-delaRosa, Aurore Hick-Colin, Elizabeth T. Borer, Eric W. Seabloom, Carlos Alberto Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Arnillas, Jonathan D. Bakker, Cynthia S. Brown, Marc W. Marchiano, Bianca Habermann, Je´rome Chal, Cadotte, Maria C. Caldeira, Pedro Daleo, John M. Alexander P. Nesmith, Svetlana Gapon, Erica Wagner, Dwyer, Philip A. Fay, Laureano A. Gherardi, Nicole Vandana A. Gupta, Rhonda Bassel-Duby, Eric N. Hagenah, Yann Hautier, Kimberly J. Komatsu, Rebecca Olson, Adam E. Cohen, Kevin Kit Parker, L. McCulley, Jodi N. Price, Rachel J. Standish, Carly J. and Olivier Pourquie´ Stevens, Peter D. Wragg, and Mahesh Sankaran

e2104668118 Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes CORRECTION Colin H. Peters, Pin W. Liu, Stefano Morotti, Stephanie C. Gantz, Eleonora Grandi, Bruce P. Bean, NEUROSCIENCE and Catherine Proenza e2109233118 Subregion-specific rules govern the SUSTAINABILITY SCIENCE distribution of neuronal immediate- e2024150118 Ecology of the Anthropocene signals hope for early gene induction consciously managing the planetary ecosystem Ben Jerry Gonzales, Diptendu Mukherjee, Clarence Lehman, Shelby Loberg, Michael Wilson, Reut Ashwal-Fluss, Yonatan Loewenstein, and Eville Gorham and Ami Citri

viii u www.pnas.org Contents Downloaded by guest on September 27, 2021