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Home , DNA polymerase beta, Gluconolactonase, Ribonuclease E, Ribulokinase, Xanthan lyase

Supporting Information for Proteomics DOI 10.1002/pmic.200701017

Cao Xuan Hieu, Birgit Voigt, Dirk Albrecht, Drte Becher, Thierry Lombardot, Frank Oliver Glckner, Rudolf Amann, Michael Hecker and Thomas Schweder

Detailed proteome analysis of growing cells of the planctomycete Rhodopirellula baltica

ª 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.proteomics-journal.com RB12697 NagA_3 CarB SecA_1 PolA RpoB GdhP ValS PutA RB6610 RB6127 PurL TolB_1 FusA_1 RB9034 RB12056 RB8067 RB641 RB12666 LeuS RB3424 RB10835 GyrB_3 AlaS RB7590 CitB RB452 Sps MutS PheT Dpp4RB6590 Sps SerC PpdK PpdK RB7538 ClpB RB1793 FusA_1 Pnp_2 ClpC PpdK RB404RB24 RB4703 Pnp_2 RB12337RB1950 FusA_2 RB973 RpsA_2 DnaK_4 RB9674Icd ThrS RB2160RB3405RB2367 RB10709TypA RB3842 RB2860 AcsA Tkt RB4561 Tig Dnak_2 RB4703RB8337 RB8843 MdoG Prc SdhA ArgS CysN RB512 DegP_4 RB9029 RB10078 RB10027 RB8745 NusA GlgB_2 Ask PmmRB9674AspS_4RB1002RpsA_1 RB6127 RB12968RB8674 Pmm GroEL_3 RB5140 RB1252 MetX RB1722 IlvD_2 GlgB_1 Ogt_3RB7190 RB6491 AceF GroEL_2 XylA Dxs MalQ RB5608 LysS PolB GpmI 6pgD RB9992 RB12905 PyrG RB9110 TypA PhoA GlyS RB6395 GabD RB5608 GuaA_2GroEL_1RB6416HtrA_1 RB8375PhoA RB9438 RB10180 SerA_2 RB12905 PilB_2 UxuB RB9029 PurH CysSCysS HemD AslA_4 GlgB_2GabD RB1523 GatB UgdH RB307PyrC_1RB2261 RB1854 AslA_4 RB1634 RB9995 GroEL_2TrpE DldH RB2254 GabD NtrC_3 RB1359 KatA RB5 RB6888 GatAGatARB5786 HisD RB9262 LeuA_2PykA RB3710NadB ArsA_9 ArsA_9 RB12461 PepT_1 RB10048 SerSRB11174 GltD GcvPB ArsA_9 SthA SthA RB11998 RB6486Pnp_2 FumC PurDAdk_1 RB8557 RB1359 RB2732 HisS GltXYqhJ ProS GlyA RB10127 NtrC_3 PepA HsdM_1 Hom AsnS ChlI NqrA RB538 RB11879 RB6977 RB8941 RB683 PgiTrkALpd RB45276pgDRB1533ThiC RB3070 AtoC_1 G6pD RB5697 RB4654 RB10127 RpoA_2 RB1579 PurB ArsA_9 RB1308 RB9402 DapE ProA EutE AccC LeuC ArsA_9 ArsA_9 RB5763 RB1359 MetKAtpA_1 AtpB_2 XylA SerC RB4582 GlyA RB1939 RB12882 RB8228 BcpC LysA_3 AhcY RB9196PfkA ThrC RB9404 RpoA_2 Pgk RB9832SerA_1 RibA RB9527 RB7598 RB4129 PrfB FabF_2 RB1555 RB9527 FixW RB12541 ScrK RB520 GltA PurB LeuC RB2630 RB9971 RB6985 RB6384RB11150 RB5186 RB1535Fdh_1 RB85 CarA TrpB RB11502 RB9971 RB4256 Eno AspC_2 Pfk RB1939TufA GlgC_1 AlgU DnaN_5 SucC MexA RB8221 GdhA MoxR_4 RB7364 TyrS FabF_3 RB6199 YacI RB8799 RB9026 RB9030 RB10061 GalM_2 MoxR_3 ManC Gcd HemL Fdh_2 RB7610 RB8221 RB10503 RB10061 HtrA_2 Trx_3RB5223 PrfA RB9261 RB9132 RB3597 RB4182 RB3330RB457 PilT_1 Tal LeuB_1 SucC Ald MoxR_9 RB10503 GcvT NqrC Tal GlnIIRB2640 CelM RB2822 RB12038 RB2782 Fmt FbaB SphX SucC KdgK AroA YjjN Tas TsfRB10124 RB3686 RB1743 PilT_2 RB3221 RB12035 Adh_3 RpoA_1 RB2518 RB8870RB7193 RB3476 RB3924 RB4399 RB4742 MoxR_8 GalE_2 KdgK PyrD_1 RB1260 RB12361 RB7785 YeaC UspA_2MoxR_10 GapA RB4759 AtpG_1 RB3733 KorB RB10652 PurC HemKRB2901 AspC_3 AspC_1 GalE_1 YbhE FbaB RB2912 PheS FbaRB8768 RB9584 GapA AroG AroG DapB RB8328 RB4744 GalM_1 IolI RB11008RB1088 RB6236 RB6603 RB12347 RB2498 RB9512 GlnII RB6236 IlvC SucDRB203 RB6771 RB12556 PyrB_2 RB10028 RB4654 DapA_1 RB6799 ThiL RB4432 RB6658 RB2501 TrpS Fpr HpnA RB11985 CheY_1RB11262 AtpG_1 CysK MraW RB12489 RB4404 Ldh_2 RB4041 RB5404 RB10287 RB4404 RB279RB8266 RB6858 AccA Gnl_2 RB10727 RB9037 AroG RB9998 GlmURB6386 RB5811 RB1248 RB2521 RB5500FabDRB10478 RB1248 ExoA GlcK_1RB1483 RB7120 GlmU LolI RB1321 RB2568 RB9518 Fba RB11728 KpsU RB7166 RB8677 RB1109 RB3632RB9945 RB1411 RB3694 RB6145RB11575 RB8846 RB5042RB3689 IlvE_2 RB12844RB321 UspA_1 RB1412 RB12844 RB2714 Gdh RB3239 SgaU MetF IlvE_2 MurBRB1044RB6530 RB10088 FabI_1 RB11010 RB10195 RB11494 HpaG RB5352 RB12167 PfaS RB13257 RB8957 RB4532 RB8783 ProC Psd_1 RB2656 RplY PyrF PtsN RB8246 PanB RB8202 RB2647 Efp_2 RB12073 RB6403 RB12372 RB1939 PhoU RB6430 DltE NusG Rpe Mip_1 RB6430 RB6469 RB4394RB10907 Pgl Pa1G RB8246 RB201 RB6403 RB2242 RibE TpiA RB6430 RB4127 RB9849 RB8163 RB10789 RB4464 RB4464 RB5031 MsrA_1 RB7235 RB6615LolD1 RB11030 RspB RuvA RB7235RB11946 RB9218 HisB GrpE Efp_1 HisH PhoB RB4866 Def RB2680 RB12301 RB569 LeuD Frr RB11516 RB11107 RB12301 RB569PyrE SodA PrdX2 Apt PyrE RB11107 RB2125 RB6586 RB2743 PrdX2 ClpP_1 AtpD_1 RB7658 RB3471 GreA RB12060 RpsP RplI CpaB ClpP_2 TPX RB7822 RB4395 FabZ_1

TPX FabZ_1 RB10483 RB4405 RB12297 Ndk RB6941 Ssb RB6792 IlvN RB9101 RplL RB4468 RB7203 RB5240 RB10530 RB9101 CypH RB9101 RB5749 Bfr PpiB RB9190 RB8067 RB4433 RB4438 RplJ RB6217 RB4347 Hsp20_2 RB4347 FruA RB1270 RbfA RB11176 RB8559 RB8067 GroES_1 RpoZ RB10956 RpsF TrxA_2 RB6217 RB1753 DksA_1 RB8520 AtpE_2 RB12634 RB6428 RB34 RB8580 RplU GroES_2 Grp GroES_2 RB4474 GlnB_2 RB5657 RB4480

RB10934 RpmC

Supplementary Figure 1

Supplementary Figure 1. The R. baltica master gel. from cells in the exponential growth phase were separated in a pH 4-7 gradient. The gel was stained with colloidal

Coomassie Brilliant Blue.

1

Supplementary Table 1. List of all identified proteins of R. baltica. COG, Clusters of Orthologous Groups of proteins were estimated on the NCBI database (A, RNA processing and modification; B, Chromatin structure and dynamics; C Energy production and conversion; D, Cell cycle control, mitosis and meiosis; E, Amino acid transport and ; F, Nucleotide transport and metabolism; G, Carbohydrate transport and metabolism;

H, Coenzyme transport and metabolism; I, Lipid transport and metabolism; J, Translation; K, Transcription; L, Replication, recombination and repair; M,

Cell wall/membrane biogenesis; N, Cell motility; O, Posttranslational modification, turnover, chaperones; P, Inorganic ion transport and metabolism; Q, Secondary metabolites biosynthesis, transport and catabolism; R, General function prediction only; S, Function unknown; T, Signal transduction mechanisms; U, Intracellular trafficking and secretion; V, Defense mechanisms; ++, not in COGs). Psortb, Predicted protein localization was obtained from PSORTb v.2.0 Precomputed (http://www.psort.org/genomes/genomes.pl). New, proteins not identified in earlier proteome studies. 1-D, 2-D and nHPLC, indicate the protein/ peptide separation method used for intracellular proteins (1-D SDS PAGE combined with nHPLC, 2-D gel electrophoresis or nHPLC). Cell wall, proteins identified in cell wall associated fractions. Extracell, secreted proteins. SP scores, signal peptide scores derived from the SignalP 3.0 server. PHX, the predicted highly expression level based on codon usage optimization described by Karlin et al.

[20].

Accession Protein Function pI Mr COG Psortb SP PHX New 1D 2D HPLC Cell Extracell Number name Score Gel Gel wall 1 Intermediary metabolism 1.1 C-compound and Carbohydrate metabolism 1.1.1 Glycolysis and Phosphogluconate pathways RB1629 GlcK_1 (EC 2.7.1.2) 5.56 38.0 K Cytoplasmic + + RB399 Pgi Glucose-6-phosphate (EC 5.3.1.9) 5.72 57.1 G Cytoplasmic + + (Synonyms: Gpi, Pgi, Phi) RB10591 Pfk PPi- (EC 2.7.1.90) 5.25 49.3 G Unknown + + + RB7572 PfkA 6-phosphofructokinase, pyrophosphate-dependent 6.20 51.8 G Cytoplasmic + + + (EC 2.7.1.11) RB6690 Fba Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) 4.69 36.7 G Cytoplasmic + + + + RB4737 FbaB Fructose-bisphosphate aldolase class I (EC 6.70 40.1 G Cytoplasmic + + 4.1.2.13) RB7095 TpiA Triosephosphate isomerase (EC 5.3.1.1) (TIM) 4.54 26.6 G Cytoplasmic + + + + + RB2627 GapA Glyceraldehyde 3-phosphate dehydrogenase (EC 5.64 36.7 G Cytoplasmic + + + + + + 1.2.1.12) RB10500 Pgk Phosphoglycerate (EC 2.7.2.3) 4.72 41.3 G Cytoplasmic + + + + RB8562 GpmI 2,3-bisphosphoglycerate-independent 4.96 59.0 G Cytoplasmic + phosphoglycerate mutase (EC 5.4.2.1) (iPGM) RB12381 Eno (EC 4.2.1.11) 4.43 45.9 G Cytoplasmic + + + + RB10277 PykA (EC 2.7.1.40) 5.24 52.2 G Cytoplasmic + + RB2735 G6pD Glucose-6-phosphate 1-dehydrogenase (EC 6.30 55.1 G Cytoplasmic + + + 1.1.1.49) (G6PD) RB9089 Pgl 6-phosphogluconolactonase (EC 3.1.1.31) 4.75 26.0 G Unknown + + RB2817 Gnd 6-phosphogluconate dehydrogenase, 5.08 54.0 G Cytoplasmic + + + + + decarboxylating (EC 1.1.1.44) RB1561 Rpe Ribulose-phosphate 3-epimerase (EC 5.1.3.1) 4.36 25.1 G Cytoplasmic + + + RB12921 Tkt Transketolase (EC 2.2.1.1) 4.99 73.4 G Unknown + + + + RB3193 Tal Transaldolase (EC 2.2.1.2) 4.56 41.4 G Cytoplasmic + + + + RB1819 GalE_1 Udp-glucose 4-epimerase (EC 5.1.3.2) 5.23 36.7 M Unknown + RB2884 GalE_2 Probable UDP-glucose epimerase (EC 5.1.3.2) 5.08 40.4 M Cytoplasmic + + RB1220 GalM_1 Probable aldose 1-epimerase (EC 5.1.3.3) 6.25 39.5 G Multipe + + localization sites RB6537 GalM_2 Aldose 1-epimerase (EC 5.1.3.3) 4.71 42.2 G Periplasmic 0.99 + + + RB3751 UDP-glucose 4-epimerase homolog (EC 5.1.3.2) 5.68 40.8 M Unknown + RB1784 UgdH UDP-glucose 6-dehydrogenase (EC 1.1.1.22) 4.67 52.3 M Unknown + RB5197 Sps Sucrose-phosphate synthase 1 (EC 2.4.1.14) 5.13 86.9 M Cytoplasmic + + + RB10002 Gcd Glucose dehydrogenase Gcd 4.88 40.7 E Cytoplasmic + + RB5577 Gnl_1 Gluconolactonase (EC 3.1.1.17) 5.14 39.6 G Unknown 0.79 + + RB12740 Gnl_2 Gluconolactonase (EC 3.1.1.17) 4.86 43.3 G Unknown + RB7294 Gdh Probable glucose 1-dehydrogenase (EC 1.1.1.47) 5.98 30.4 Q Cytoplasmic + RB683 Aldehyde dehydrogenase (EC 1.2.1.3) 4.80 52.5 C Cytoplasmic + + + + RB8941 Ketoglutarate semialdehyde dehydrogenase (EC 4.65 58.0 C Cytoplasmic + + 1.2.1.3) RB10172 Aldehyde dehydrogenase (EC 1.2.1.3) 5.05 53.4 C Cytoplasmic + + RB8731 KdgK 2-keto-3-deoxygluconate kinase (EC 2.7.1.45) 5.15 39.4 G Unknown + + + RB1998 PpdK Pyruvate,phosphate dikinase (EC 2.7.9.1) 6.10 97.0 G Cytoplasmic + + + + + + + RB6729 DeoC Deoxyribose-phosphate aldolase (EC 4.1.2.4) 5.34 27.9 F Cytoplasmic + + (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA) RB4944 Ppc Phosphoenolpyruvate carboxylase (EC 4.1.1.31) 6.69 104.6 C Unknown + + (PEPC) (PEPCase)

1.1.2 Tricarboxylic acid cycle RB3424 Pyruvate dehydrogenase E1 component (EC 5.16 101.5 C Unknown + + + 1.2.4.1) RB3423 AceF Pyruvate dehydrogenase, E2 component, 4.71 48.5 C Cytoplasmic + + + + + dihydrolipoamide acetyltransferase (EC 2.3.1.12) RB2718 DldH Dihydrolipoamide dehydrogenase (EC 1.8.1.4) 4.95 50.5 C Cytoplasmic + + + + RB1231 Lpd Dihydrolipoamide dehydrogenase (EC 1.8.1.4) 4.95 50.0 C Cytoplasmic + + + RB6683 GltA Citrate synthase (EC 4.1.3.7) 6.15 55.5 C Cytoplasmic + RB2114 CitB Aconitate hydratase (EC 4.2.1.3) 4.62 96.7 C Cytoplasmic + + + + RB1593 Icd Isocitrate dehydrogenase (EC 1.1.1.42) 4.74 79.8 C Unknown + + RB6935 KorA 2-oxoglutarate ferredoxin alpha 5.80 67.3 C Unknown + + + subunit (EC 1.2.7.3) RB6933 KorB 2-oxoglutarate ferredoxin oxidoreductase beta 6.95 38.6 C Unknown + + subunit (EC 1.2.7.3) RB10619 SucD Putative succinyl-CoA synthetase alpha subunit 4.78 29.9 C Unknown + + + (EC 6.2.1.5) RB10617 SucC Succinyl-CoA synthetase (Beta subunit) (EC 4.84 44.1 C Cytoplasmic + + + 6.2.1.5) RB10554 SdhA Succinate dehydrogenase subunit A (EC 1.3.99.1) 5.13 73.9 C Cytoplasmic + + + + RB10555 SdhB Succinate dehydrogenase subunit B (EC 1.3.99.1) 7.77 31.6 C Cytoplasmic + + RB10553 SdhC Succinate dehydrogenase cytochrome B-558 6.51 32.9 C Cytoplasmic + + subunit (EC 1.3.99.1) membrane RB7623 FumC Fumarate hydratase FumC (EC 4.2.1.2) 4.72 58.6 C Cytoplasmic + + + + + RB856 Ldh_1 L-lactate/malate dehydrogenase (EC 1.1.1.27) (EC 4.94 33.1 C Cytoplasmic 0.83 + 1.1.1.37) RB8859 LdhA D-lactate dehydrogenase (Fermentative) (EC 4.58 36.4 C Cytoplasmic + + 1.1.1.28) RB7652 Mdh Malate dehydrogenase (EC 1.1.1.37) 4.52 33.1 C Cytoplasmic + + + RB13264 AcsA Acetyl-coenzyme A synthetase (EC 6.2.1.1) 4.86 74.1 I Cytoplasmic + + RB307 NAD-dependent malic (EC 1.1.1.38) 5.02 50.6 C Cytoplasmic + +

1.1.3 Glycogen synthesis and degradation RB6654 GlgA Glycogen synthase (EC 2.4.1.21) 5.17 56.3 G Cytoplasmic + + RB548 GlgB_1 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) 4.50 72.0 G Cytoplasmic + + RB2638 GlgB_2 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) 5.65 83.6 G Unknown + + RB10465 GlgC_2 Glucose-1-phosphate adenylyltransferase (EC 5.98 47.4 G Unknown + + 2.7.7.27) RB8383 GlgP 2 (EC 2.4.1.1) 5.05 94.2 G Cytoplasmic + + + + RB2160 Alpha-amylase (EC 3.2.1.1) 4.73 81.5 G Cytoplasmic + + RB4161 MalQ 4-alpha-glucanotransferase (EC 2.4.1.25) 4.34 57.4 G Cytoplasmic + + RB9292 GlgX_2 Glycogen operon protein glgX-2 (EC 3.2.1.-) 6.35 82.3 G Cytoplasmic + + +

1.1.4 Sugar and Polysaccharide Degradation RB8788 AraB L- (EC 2.7.1.16) 4.81 60.1 C Cytoplasmic + + RB6254 ManC Mannose-1-phosphate (EC 4.89 38.9 M Cytoplasmic + 2.7.7.22) RB6061 Pmm Phosphomannomutase (EC 5.4.2.8) 4.87 66.9 G Unknown + + RB9832 Phosphomannomutase (Pmm) 5.62 50.5 G Unknown + + + RB2518 GDP-mannose 4,6 (EC 4.2.1.47) 5.40 39.8 M Unknown + + + RB2521 GDP-fucose synthetase (EC 5.1.3.-) 6.51 34.6 M Cytoplasmic + + + RB2403 UxuB D-mannonate oxidoreductase (EC 1.1.1.57) 4.53 56.5 G Unknown + RB2658 XylA Xylose isomerase (EC 5.3.1.5) 5.53 50.6 G Cytoplasmic + + + + RB5406 Carbohydrate kinase, FGGY family (EC 2.7.1.-) 4.84 60.5 G Unknown + + RB2568 L-fuculose-phosphate aldolase (EC 4.1.2.17) 6.17 32.3 G Unknown + + + RB8785 FucI Hypothetical protein fucI (EC 5.3.1.-) 4.89 59.8 ++ Cytoplasmic + + RB3762 GlpK (EC 2.7.1.30) (GK) 6.13 59.4 C Unknown + + RB5198 ScrK Probable (EC 2.7.1.4) 4.41 37.0 G Cytoplasmic + + RB10127 Protein up-regulated by thyroid hormone-putative 4.79 51.4 G Unknown 0.96 + + + PQQ-dependent glucose dehydrogenase (EC 1.1.99.17) RB2986 Oligo-1,6-glucosidase (EC 3.2.1.10) 5.45 66.9 G Cytoplasmic + +

1.1.5 Other related pathways 1.1.5.1 Amine and Polyamine degradation RB12652 GlmS Glucosamine-fructose-6-phosphate 6.51 64.5 M Cytoplasmic + + aminotransferase (EC 2.6.1.16) RB6841 GlmU UDP-N-acetylglucosamine pyrophosphorylase (EC 4.59 28.9 M Cytoplasmic + 2.7.7.23) RB6977 UDP-N-acetylhexosamine pyrophosphorylase (EC 4.58 53.1 G Cytoplasmic + + 2.7.7.-) (EC 2.7.7.23) RB977 NagA_1 Probable N-acetylglucosamine-6-phosphate 4.30 130.6 Q Unknown 0.99 + + deacetylase (EC 3.5.1.25) RB2586 EutM Probable ethanolamine utilization protein EutM 9.18 10.0 Q Unknown + + + RB8551 HpnA HpnA protein 6.87 41.7 M Cytoplasmic + + + RB9168 Nucleotide sugar epimerase 5.07 36.3 M Unknown +

1.1.5.2 C1 coumpound metabolism RB2373 Fdh_1 Probable formaldehyde dehydrogenase 5.40 42.5 E Cytoplasmic + + RB13260 YhdH Putative zinc-binding alcohol dehydrogenase (EC 4.60 34.8 C Cytoplasmic + 1.1.1.1) membrane RB4131 YjjN Zinc-type alcohol dehydrogenase (EC 1.1.1.1) 5.24 37.3 E Cytoplasmic +

1.1.5.3 Metabolism of other carbohydrates RB8924 BcpC Probable phosphonopyruvate decarboxylase 1 4.59 48.1 G Unknown + + + (EC 4.1.1.-) RB8541 CelM Probable endoglucanase (EC 3.2.1.4) 4.65 38.3 G Cytoplasmic + + RB1988 GdhP Similar to glucose dehydrogenase-B (EC 4.76 127.1 C Unknown 1.00 + 1.1.99.17) RB1210 SgaU Probable hexulose-6-phosphate isomerase (EC 5.- 4.53 30.7 G Cytoplasmic + + + .-.-) RB201 Sugar phosphate isomerase/epimerase (EC 5.3.1.- 5.52 31.3 G Cytoplasmic + + ) RB203 Putative oxidoreductase-possibly Aldo/keto 6.59 39.1 C Cytoplasmic + + reductase RB344 Probable xanthan 4.96 77.1 O Unknown 1.00 + RB7762 Probable xanthan lyase 5.01 111.6 L Cytoplasmic + + RB422 SuhB_1 Inositol-1-monophosphatase (EC 3.1.3.25) 4.84 31.6 G Unknown + + RB1412 Inositol monophosphatase family protein 4.76 33.6 G Unknown + RB3239 Probable D-tagatose 3-epimerase (EC 5.3.1.-) 4.36 29.9 G Cytoplasmic + + + RB4561 Beta-hexosaminidase (EC 3.2.1.52) 6.32 84.9 G Periplasmic 0.92 + + RB6241 Probable hexosyltransferase (EC 2.4.1.-) 7.96 44.9 M Unknown + + + RB10092 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene- 5.21 37.1 Q Unknown + 1,7-dioic acid hydratase (EC 5.3.3.-) (EC 4.1.1.-) RB10124 Probable polyvinylalcohol dehydrogenase 6.72 52.2 S Unknown 0.77 + + + RB12361 Predicted family sugar kinase (EC 4.38 37.4 G Cytoplasmic + 2.7.1.-) RB8073 Abf2 Alpha-L-arabinofuranosidase II (EC 3.2.1.55) 5.10 40.7 R Unknown 0.83 + RB3601 Probable alginate lyase (EC 4.2.2.3) 5.6 27.5 ++ Multipe 0.99 + + localization sites

1.2 Amino acids and Proteins 1.2.1 Amino acid metabolism 1.2.1.1 Alanine and Aspartate metabolism RB1363 Ald Alanine dehydrogenase (EC 1.4.1.1) 4.94 38.2 E Cytoplasmic + + RB8219 AspC_2 Aspartate aminotransferase (EC 2.6.1.1) 5.65 43.0 E Unknown + RB12864 AspC_3 Aspartate aminotransferase (EC 2.6.1.1) 5.17 43.1 E Cytoplasmic + + + RB7985 AnsA L-asparaginase (EC 3.5.1.1) 5.19 50.1 E Periplasmic 0.99 + + RB4577 AsnB_2 Asparagine synthetase (EC 6.3.5.4) 6.57 72.3 E Cytoplasmic + + RB11582 Cysteine desulfurase 5.61 41.8 E Unknown + RB3597 NifS protein homolog yurW (EC 4.4.1.-) 6.10 46.8 E Cytoplasmic + +

1.2.1.2 Arginine, Glutamate and Proline metabolism RB8540 ArgA Probable N-acetylglutamate synthase (EC 2.3.1.1) 7.92 15.6 E Cytoplasmic + + + RB5983 ArgB N-acetyl-L-glutamate 5- (EC 4.68 31.1 E Cytoplasmic + + + 2.7.2.8) (AGK) RB8633 ArgD Probable acetylornithine aminotransferase 6.05 50.5 E Unknown + + RB8293 ArgG Argininosuccinate synthase (EC 6.3.4.5) 4.60 49.3 E Cytoplasmic + + (Citrulline--aspartate ) RB3255 ArgJ Arginine biosynthesis bifunctional protein argJ (EC 4.73 42.5 E Cytoplasmic + + 2.3.1.35 and EC 2.3.1.1) RB3708 SpeA Biosynthetic arginine decarboxylase (EC 4.1.1.19) 5.00 74.1 E Multipe + + + (ADC) localization sites RB5179 CarA Carbamoyl-phosphate synthase, small chain (EC 5.26 42.2 E Cytoplasmic + + + 6.3.5.5) RB12113 CarB Carbamoyl-phosphate synthase (Glutamine- 4.60 118.1 E Multipe + + + + hydrolyzing) large chain (EC 6.3.5.5) localization sites RB8262 PutA Proline dehydrogenase / 1-pyrroline-5-carboxylate 4.92 137.6 C Cytoplasmic + + dehydrogenase (EC 1.5.99.8) (EC 1.5.1.12) RB6930 GdhA Glutamate dehydrogenase A (EC 1.4.1.3) 6.37 45.7 E Cytoplasmic + + + RB9215 SucB Dihydrolipoamide succinyltransferase component 5.05 45.8 C Cytoplasmic + + + + + of 2-oxoglutarate dehydrogenase complex (EC membrane 2.3.1.61) RB10968 GabD Succinate-semialdehyde dehydrogenase (EC 4.38 50.2 C Cytoplasmic + + + + 1.2.1.16) RB7247 GlnII Glutamine synthetase (EC 6.3.1.2) (Glutamate-- 4.81 40.4 E Cytoplasmic + + + + + ammonia ligase) RB5653 GltD NADH-glutamate synthase small chain (EC 4.93 55.0 E Cytoplasmic + + + + + 1.4.1.13) RB7359 ProA Gamma-glutamyl phosphate reductase (GPR) (EC 5.07 46.1 E Cytoplasmic + + + 1.2.1.41) RB3891 ProC Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 5.32 28.2 E Cytoplasmic + +

1.2.1.3 Phenylalanine, tyrosine and tryptophan metabolism RB7096 AroA Phospho-2-dehydro-3-deoxyheptonate aldolase / 5.09 37.9 E Cytoplasmic + + chorismate mutase (EC 4.1.2.15) (EC 5.4.99.5) RB6822 AroC Chorismate synthase (EC 4.6.1.4) 6.19 42.9 E Unknown + + RB6821 AspC_1 Aspartate aminotransferase (EC 2.6.1.1) 4.88 46.6 E Cytoplasmic + + + RB12510 AroG Phospho-2-dehydro-3-deoxyheptonate aldolase 6.60 38.1 E Cytoplasmic + (EC 4.1.2.15) RB6488 3-dehydroquinate dehydratase / shikimate 5- 7.27 55.4 E Unknown + + dehydrogenase (EC 4.2.1.10) (EC 1.1.1.25) RB2278 3-phosphoshikimate 1-carboxyvinyltransferase 4.53 53.2 E Unknown + (EC 2.5.1.19) RB10650 TrpB beta chain (EC 4.2.1.20) 5.73 44.3 E Cytoplasmic + + RB6300 TrpG_2 Anthranilate synthase component II (Glutamine 5.50 22.9 E Cytoplasmic + amido-) (EC 4.1.3.27) RB7967 TrpE Anthranilate synthase component I (EC 4.1.3.27) 5.15 61.1 E Cytoplasmic + + +

1.2.1.4 Lysine and Methionine metabolism RB9795 Asd Aspartate-semialdehyde dehydrogenase (EC 4.82 36.4 E Cytoplasmic + + 1.2.1.11) RB8926 Ask Probable aspartokinase (EC 2.7.2.4) 4.61 62.4 E Cytoplasmic + + + RB8510 Hom Homoserine dehydrogenase (EC 1.1.1.3) 4.87 47.6 E Unknown + + RB2746 DapA_1 Dihydrodipicolinate synthase (EC 4.2.1.52) 4.90 33.4 E Unknown + RB1411 Probable dihydrodipicolinate synthase (EC 6.23 37.5 E Unknown + + + 4.2.1.52) RB11959 DapB Dihydrodipicolinate reductase (EC 1.3.1.26) 5.48 29.2 E Unknown + + (DHPR) RB12133 DapE ArgE/DapE/Acy1 family protein (EC 3.5.1.16) (EC 4.68 50.3 E Unknown + + 3.5.1.18) RB1538 LysA_1 Hypothetical 49.9 kDa protein Y4YA-putative 6.82 55.2 E Cytoplasmic + + diaminopimelate decarboxylase (EC 4.1.1.20) RB9188 LysA_2 Diaminopimelate decarboxylase (EC 4.1.1.20) 4.71 47.2 E Unknown + + + RB4382 Probable diaminopimelate decarboxylase (EC 7.36 62.8 E Cytoplasmic + + 4.1.1.20) RB6285 AhcY S-adenosyl-L-homocysteine (EC 4.75 49.1 H Cytoplasmic + + + + 3.3.1.1) RB8221 O-acetylhomoserine sulfhydrylase (EC 4.2.99.10) 6.32 47.7 E Cytoplasmic + + + + RB8222 MetX Homoserine O-acetyltransferase (EC 2.3.1.31) 4.55 68.9 E Cytoplasmic + + RB5444 MetK S-adenosylmethionine synthetase (EC 2.5.1.6) 4.76 42.4 H Cytoplasmic + + + (MAT) RB6443 MetB_2 Cystathionine gamma-lyase homolog (EC 4.4.1.1) 5.49 42.8 E Cytoplasmic + +

1.2.1.5 Serine, Glycine and Threonine metabolism RB6248 SerA_1 Phosphoglycerate dehydrogenase (EC 1.1.1.95) 5.09 57.7 E Cytoplasmic + + + RB10004 SerA_2 Phosphoglycerate dehydrogenase SerA2-putative 4.91 39.4 E Cytoplasmic + + NAD-dependent 2-hydroxyacid dehydrogenase (EC 1.1.1.95) RB6246 SerC Phosphoserine aminotransferase (EC 2.6.1.52) 5.24 41.8 H Cytoplasmic + + + + (PSAT) RB6215 GlyA Serine hydroxymethyltransferase (EC 2.1.2.1) 5.98 45.4 E Cytoplasmic + + + + + (SHMT) RB7546 MetF 5,10-methylenetetrahydrofolate reductase 4.61 32.1 E Cytoplasmic + + RB5856 Adh_1 Alcohol dehydrogenase, zinc-containing (EC 5.57 41.8 E Cytoplasmic + + 1.1.1.1) RB5948 Adh_2 Probable alcohol / threonine dehydrogenase (Zn- 4.83 36.7 E Cytoplasmic + + dependent) (EC 1.1.1.1) RB7585 YqhJ Glycine dehydrogenase subunit 1 (EC 1.4.4.2) 5.24 52.3 E Unknown + + RB7584 YqhK Probable glycine dehydrogenase [decarboxylating] 5.66 54.5 E Unknown + + subunit 2 (EC 1.4.4.2) RB7587 GcvT Probable aminotransferase-glycine cleavage 6.74 42.4 E Cytoplasmic + + system T protein (EC 2.1.2.10) RB6932 CysK Cysteine synthase (O-acetylserine sulfhydrylase) 5.02 33.7 E Cytoplasmic + + (EC 4.2.99.8) membrane RB10894 ThrC (EC 4.2.3.1) (EC 4.2.99.2) 6.44 49.5 E Unknown + + + (EC 4.2.1.16) (EC 4.2.99.8) RB10307 Gly1 Low specificity L-threonine aldolase 5.74 38.5 E Unknown + + RB6394 Probable 2-hydroxyacid dehydrogenase (EC 6.68 43.7 C Cytoplasmic + 1.1.1.95) (EC 1.1.1.29)

1.2.1.6 Histidine metabolism RB8080 HisA 1-(5-phosphoribosyl)-5-[(5- 4.47 27.5 E Cytoplasmic + phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) RB7662 HisB Imidazoleglycerol-phosphate dehydratase (EC 6.22 21.8 E Unknown + + + 4.2.1.19) (IGPD) RB1584 HisD Histidinol dehydrogenase (EC 1.1.1.23) (HDH) 4.80 48.5 E Unknown + + RB5601 HisE Phosphoribosyl-ATP pyrophosphatase (EC 5.87 17.3 E Cytoplasmic + + + 3.6.1.31) (PRA-PH) RB10112 HisF Imidazole glycerol phosphate synthase subunit 5.39 28.2 E Cytoplasmic + + hisF (EC 4.1.3.-) RB5603 HisG ATP phosphoribosyltransferase (EC 2.4.2.17) 4.97 32.6 E Cytoplasmic + + (ATP-PRTase) RB9372 HisH Imidazole glycerol phosphate synthase subunit 4.89 22.0 E Unknown + + hisH (EC 2.4.2.-)

1.2.1.7 Valine, Leucine and Isoleucine metabolism RB9869 IlvC Ketol-acid reductoisomerase (EC 1.1.1.86) 4.74 36.5 E Cytoplasmic + + + + + RB12087 IlvD_3 Dihydroxy-acid dehydratase (EC 4.2.1.9) (DAD) 5.03 62.5 E Unknown + + + RB8126 IlvE_2 Putative branched-chain amino acid 4.74 31.0 E Cytoplasmic + + + aminotransferase (EC 2.6.1.42) RB9871 IlvN Probable acetolactate synthase small subunit (EC 5.05 21.3 E Unknown + + + + 4.1.3.18) RB12905 Acetolactate synthase III (EC 4.1.3.18) 6.04 67.0 E Cytoplasmic + + RB1317 LeuA_1 2-isopropylmalate synthase (EC 4.1.3.12) 5.18 57.5 E Unknown + RB3767 LeuB_1 3-isopropylmalate dehydrogenase (EC 1.1.1.85) 4.59 39.6 E Cytoplasmic + + RB12597 LeuB_2 3-isopropylmalate dehydrogenase (EC 1.1.1.85) 4.85 39.7 E Cytoplasmic + + RB12656 LeuC 3-isopropylmalate dehydratase large subunit (EC 6.03 55.1 E Cytoplasmic + + 4.2.1.33) RB12658 LeuD 3-isopropylmalate dehydratase small subunit (EC 4.44 22.4 E Cytoplasmic + + + + 4.2.1.33)

1.2.2 Protein / peptide processing 1.2.2.1 Proteases / peptidases RB7367 DegP_3 Periplasmic serine proteinase DO (EC 3.4.21.-) 4.45 68.5 O Periplasmic 0.99 + + RB7368 DegP_4 Serine proteinase, HtrA/DegQ/DegS family (EC 8.23 40.7 O Periplasmic + + + 3.4.21.-) RB299 HtrA_1 Probable serine protease HtrA (EC 3.4.21.-) 4.96 46.5 O Multipe + + localization sites RB10249 HtrA_3 Similar to serine proteinase HtrA (EC 3.4.21.-) 5.45 52.2 O Unknown 0.99 + + RB12148 Prc Periplasmic tail-specific proteinase (EC 3.4.21.-) 4.62 79.2 M Unknown 1.00 + + + + + RB11879 Probable periplasmic serine proteinase (EC 4.57 50.0 O Multipe + + 3.4.21.-) localization sites RB1359 Probable serine protease do-like DEGP (EC 6.54 66.7 O Periplasmic + + 3.4.21.-) RB5645 Serine protease (EC 3.4.21.-) 5.21 60.7 O Periplasmic + + RB4394 Proteinase I 4.41 20.6 R Cytoplasmic + + + + RB7590 Probable proteinase (EC 3.4.-.-) 4.72 110.9 R Cytoplasmic + + + RB9029 Probable zinc metalloproteinase (EC 3.4.24.71) 4.89 85.7 O Cytoplasmic + + RB9402 Hypothetical zinc protease (EC 3.4.99.-) 4.58 47.2 R Unknown + + + RB9404 Hypothetical zinc protease (EC 3.4.99.-) 4.25 46.3 R Cytoplasmic + + + RB10027 Hypothetical protein putative protease 5.08 126.2 S Unknown + + + RB1579 Thermostable carboxypeptidase 1 (EC 3.4.17.19) 4.58 59.4 E Cytoplasmic + + RB2261 Carboxypeptidase-related protein (EC 3.4.16.-) 5.46 61.1 E Unknown + + RB12107 PepA Leucine aminopeptidase (EC 3.4.11.1) (LAP) 4.72 53.0 E Unknown + + + RB5627 PepN Probable aminopeptidase (EC 3.4.11.-) 5.17 100.3 E Outer 1.00 + + + + membrane RB10586 PepQ Probable X-pro aminopeptidase homolog PepQ2 4.89 43.3 E Cytoplasmic + (EC 3.4.13.-) RB7375 PepT_1 Aminopeptidase T (EC 3.4.11.-) 4.44 44.4 E Cytoplasmic + RB12337 Prolyl endopeptidase (EC 3.4.21.26) 4.62 84.2 E Periplasmic 0.99 + + RB1225 Dpp4 Dipeptidyl peptidase IV (EC 3.4.14.5) 4.81 93.2 E Unknown 1.00 + + RB3842 Dipeptidyl peptidase IV 5.24 79.1 E Unknown 0.99 + RB9674 Putative Xaa-Pro dipeptidyl-peptidase (EC 5.02 70.0 R Cytoplasmic 0.99 + + 3.4.14.11) (X-PDAP) RB7940 Dcp Peptidyl-dipeptidase DCP (EC 3.4.15.5) 4.79 84.0 E Cytoplasmic + + + RB393 Similar to peptidase 7.88 70.8 O Unknown + + RB10180 Peptidase (EC 3.4.24.-) 4.68 68.9 E Cytoplasmic + + +

1.2.2.2 Protein modification RB3446 Peptidyl-prolyl cis-trans isomerase cyp2 (EC 5.09 57.3 O Multipe + 5.2.1.8) localization sites RB8476 PpiC Peptidyl-prolyl cis-trans isomerase C2 4.61 10.0 O Multipe + + localization sites RB4395 Probable macrophage infectivity potentiator protein 4.69 18.8 S Unknown + + Mip RB6620 PpiD Probable peptidyl-prolyl cis-trans isomerase (EC 6.81 44.4 O Multipe + + 5.2.1.8) localization sites RB7244 PpiB Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) 4.71 15.9 O Cytoplasmic + RB8649 CypH Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) 7.84 21.7 O Multipe 1.00 + + + + localization sites RB9569 Mip_1 Probable macrophage infectivity potentiator protein 5.00 21.9 S Unknown + + + Mip (EC 5.2.1.8) RB10129 Mip_2 Macrophage infectivity potentiator (EC 5.2.1.8) 4.89 26.2 O Outer 1.00 + + + membrane RB12856 Def Peptide deformylase (EC 3.5.1.88) (PDF) 4.66 22.5 J Cytoplasmic + + RB11847 MsrA_1 Peptide methionine sulfoxide reductase (EC 6.91 26.8 O Unknown 0.99 + 1.8.4.6) RB2268 MsrB_1 Peptide methionine sulfoxide reductase (EC 9.43 31.1 O Unknown + + 1.8.4.6) RB10733 Fdh_2 Glutathione-dependent formaldehyde 4.80 42.3 E Cytoplasmic + + dehydrogenase (EC 1.2.1.1) RB7823 Probable transaminase 5.69 54.2 E Unknown + RB10165 Similar to polyhydroxyalkanoate depolymerase 4.74 117.8 R Unknown 0.99 + + RB10287 Similar to dihydropicolinate synthase 4.34 33.2 E Cytoplasmic + + + RB6123 Similar to protein disulfide-isomerase 4.47 82.8 R Cytoplasmic + +

1.3 Nucleotides 1.3.1 Purine metabolism RB1079 Adk_1 Probable (EC 2.7.4.3) 5.00 50.0 F Cytoplasmic + + + RB5847 Apt Adenine phosphoribosyltransferase (EC 2.4.2.7) 5.08 22.7 F Cytoplasmic + + (APRT) RB12924 PurA Adenylosuccinate synthetase (EC 6.3.4.4) (IMP-- 5.32 47.5 F Cytoplasmic + + + + aspartate ligase) (AdSS) (AMPSase) RB8343 PurB Adenylosuccinate lyase (EC 4.3.2.2) 5.64 54.0 F Cytoplasmic + + + RB12194 PurC Phosphoribosylaminoimidazole- 4.56 36.6 F Unknown + + succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) RB6616 PurD Phosphoribosylamine-glycine ligase (EC 6.3.4.13) 5.37 48.3 F Unknown + + + RB10113 PurH Bifunctional purine biosynthesis protein purH (EC 4.63 56.2 F Cytoplasmic + + + 2.1.2.3) (EC 3.5.4.10) RB5395 PurL Phosphoribosylformylglycinamidine synthase II 4.38 108.2 F Unknown + + + (EC 6.3.5.3) RB12745 PurM Phosphoribosylformylglycinamidine cyclo-ligase 5.59 44.7 F Unknown + (EC 6.3.3.1) (AIRS) (Phosphoribosyl- aminoimidazole synthetase) (AIR synthase) RB256 PurU Formyltetrahydrofolate deformylase (EC 3.5.1.10) 5.51 32.9 F Cytoplasmic + RB6524 Hpt Hypoxanthine-guanine phosphoribosyltransferase 4.36 19.4 F Cytoplasmic + (EC 2.4.2.8) RB8374 GuaA_1 GMP synthase [glutamine-hydrolyzing] (EC 4.94 64.6 F Cytoplasmic + + 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase) RB11822 GuaB Inosine-5'-monophosphate dehydrogenase (EC 9.34 57.9 F Unknown + + 1.1.1.205) RB8613 PfaS Phosphoribosylformylglycinamidine synthase I 6.28 32.1 F Cytoplasmic + (PurQ) (EC 6.3.5.3) RB11832 Ndk Nucleoside diphosphate kinase (NDK) (EC 2.7.4.6) 4.70 17.1 F Cytoplasmic + + RB12762 NrdA Ribonucleotide reductase (EC 1.17.4.1) 4.89 113.5 F Unknown + + + + RB417 IunH Inosine-uridine preferring nucleoside hydrolase 4.90 33.9 F Cytoplasmic + + (EC 3.2.2.1) RB11853 FolE GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I) 6.63 25.4 H Cytoplasmic + +

1.3.2 Pyrimidine metabolism RB7429 PyrB_1 Aspartate carbamoyltransferase (EC 2.1.3.2) 6.57 37.7 F Cytoplasmic + + (ATCase) RB7430 PyrC_1 Dihydroorotase (EC 3.5.2.3) 6.51 48.5 F Cytoplasmic + + + RB10192 PyrC_2 Dihydroorotase (EC 3.5.2.3) 5.27 51.0 F Cytoplasmic 0.85 + + RB4752 PyrD_1 Dihydroorotate dehydrogenase (EC 1.3.3.1) 5.42 39.1 F Unknown + RB328 PyrE Orotate phosphoribosyltransferase (EC 2.4.2.10) 4.74 22.1 F Cytoplasmic + + + + + (OPRT) RB12661 PyrF Orotidine 5-phosphate decarboxylase (EC 4.70 31.9 F Unknown + + + 4.1.1.23) RB12061 PyrG CTP synthase (EC 6.3.4.2) 6.00 61.9 F Cytoplasmic + + RB3884 PyrH_1 Uridylate kinase (EC 2.7.4.-) 9.91 38.5 F Cytoplasmic + + membrane RB1742 PyrK Dihydroorotate dehydrogenase electron transfer 5.03 30.8 H Unknown + + subunit RB5717 SthA Soluble pyridine nucleotide transhydrogenase 6.45 54.1 C Cytoplasmic + + RB10188 Upp Uracil phosphoribosyltransferase 6.30 23.0 F Cytoplasmic + + RB2394 Cmk Probable (EC 2.7.4.14) 7.43 27.1 F Cytoplasmic + +

1.4 Lipids, Fatty Acids and Isoprenoids RB8310 AccA AcetylCoA-Carboxylase (EC 6.4.1.2) 6.58 35.8 I Cytoplasmic + + RB8548 AccB Acetyl-CoA carboxylase (Biotin carboxyl carrier 4.08 18.3 I Cytoplasmic + + subunit) accB RB8550 AccC Biotin carboxylase (EC 6.3.4.14) 5.34 49.3 I Cytoplasmic + + RB314 FabD Malonyl CoA-acyl carrier protein transacylase (EC 4.45 32.4 I Cytoplasmic + + + 2.3.1.39) RB320 FabF_1 3-oxoacyl-[acyl-carrier-protein] synthase (EC 5.14 45.1 I Cytoplasmic + + 2.3.1.41) RB318 AcpP_1 Acyl carrier protein (ACP) 3.72 9.0 I Cytoplasmic + + RB7168 AcpP_2 Probable acyl carrier protein 3.81 14.4 I Unknown + + + + RB7171 FabF_3 3-oxoacyl-(Acyl-carrier protein) synthase (EC 4.94 45.3 I Cytoplasmic + + 2.3.1.41) RB4527 3-oxoacyl-(Acyl-carrier protein) synthase (EC 5.06 46.7 I Cytoplasmic + + 2.3.1.41) RB316 FabG_1 3-oxoacyl-(Acyl-carrier protein) reductase (EC 7.86 26.1 Q Cytoplasmic + + + 1.1.1.100) RB10790 FabI_2 Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.9) 7.02 32.5 I Cytoplasmic + + + RB10466 FabZ_4 Probable beta-hydroxyacyl-ACP dehydratase (EC 5.06 19.6 I Cytoplasmic + + + 4.2.1.-) RB6563 KdsA 2-dehydro-3-deoxyphosphooctonate aldolase (EC 4.77 30.4 M Cytoplasmic + + + 2.5.1.55) (Phospho-2-dehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase) (KDOPS)

RB12690 KpsU 3-deoxy-manno-octulosonate cytidylyltransferase 4.74 27.4 M Unknown + + (EC 2.7.7.38) RB8482 Psd_2 Phosphatidylserine decarboxylase (EC 4.1.1.65) 6.52 36.2 I Unknown + + RB2579 EutE Ethanolamine utilization protein EutE 5.22 50.7 C Cytoplasmic + + RB6500 Mycocerosate synthase 5.04 400.4 Q Multipe + + localization sites RB11943 Phytoene dehydrogenase (EC 1.14.99.-) 6.27 57.9 Q Unknown + + + RB3656 Probable polyketide cyclase 6.69 34.6 R Unknown 1.00 + + RB10446 Probable multi-domain beta keto-acyl synthase- 5.65 316.9 Q Unknown + + possibly involved in fatty acid or polyketide biosynthesis

1.5 Vitamins, Cofactors and Prosthetic Groups 1.5.1 NAD biosynthesis RB7425 NadA Quinolinate synthetase (EC 1.4.3.16) 5.53 46.2 H Cytoplasmic + + RB3824 NadB L-aspartate oxidase (EC 1.4.3.16) 6.18 60.9 H Multipe + localization sites RB5671 NadE Glutamine-dependent NAD(+) synthetase (EC 5.83 76.9 R Unknown + + 6.3.5.1)

1.5.2 FMN and FAD biosynthesis RB12480 RibA Riboflavin biosynthesis protein RibA (EC 3.5.4.25) 5.85 44.6 H Cytoplasmic + + RB12379 RibE Riboflavin synthase alpha chain (EC 2.5.1.9) 4.69 25.7 H Unknown 0.90 + +

1.5.3 Siroheme biosynthesis RB7020 HemD Uroporphyrinogen III synthase/methyltransferase 5.86 55.2 H Unknown + + (EC 2.1.1.107) (EC 4.2.1.75) RB6831 HemL Probable glutamate-1-semialdehyde 2,1- 5.12 45.9 H Unknown + aminomutase (EC 5.4.3.8) RB6485 HemN_1 Coproporphyrinogen III oxidase 4.95 53.2 H Cytoplasmic + + + RB9306 HemK HemK protein 4.64 32.9 J Cytoplasmic + + +

1.5.4 Other cofactors RB2143 Dxs 1-deoxy-D-xylulose-5-phosphate synthase (EC 5.37 69.5 H Cytoplasmic + + 2.2.1.7) (DXPS) RB6809 ThiL Thiamine-monophosphate kinase (EC 2.7.4.16) 4.25 33.8 H Unknown + RB4069 MoaA Molybdopterin synthesis protein A 6.27 39.7 H Cytoplasmic + + RB12666 Molybdopterin oxidoreductase, iron-sulfur binding 5.03 131.4 C Cytoplasmic + + + + subunit (EC 1.2.7.-) RB3451 IspF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 5.01 17.8 I Cytoplasmic + + synthase (EC 4.6.1.12) (MECPS) RB309 ChlI Probable magnesium protoporphyrin chelatase 5.08 54.0 H Cytoplasmic + + RB9090 PanB 3-methyl-2-oxobutanoate 5.37 28.9 H Cytoplasmic + + hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) RB4396 Glutathione reductase (EC 1.6.4.2) 5.09 48.5 C Cytoplasmic + + RB9966 AstB/chuR-related protein-putative enzyme of the 7.75 52.4 R Unknown + + MoaA / nifB / pqqE family RB24 Similar to L-sorbosone dehydrogenase (EC 1.1.1.- 5.29 101.1 G Unknown + + ) RB1308 Probable phytoene dehydrogenase (EC 1.14.99.-) 7.07 56.4 Q Cytoplasmic + + RB8311 Probable yloP (EC 2.7.1.-) 9.75 42.2 R Cytoplasmic + + membrane

1.6 Inorganic Compounds 1.6.1 Sulfur/sulfite compounds RB6049 CysC Adenylylsulfate kinase (EC 2.7.1.25) 4.96 29.4 P Cytoplasmic + RB7941 CysN CysN/cysC bifunctionyal enzyme (EC 2.7.1.25) 5.25 71.2 P Cytoplasmic + + RB7465 Sir Sulfite reductase (EC 1.8.7.1) 5.49 68.8 P Cytoplasmic + +

1.6.2 Ferrit compounds RB10463 Fpr Probable ferredoxin--NADP reductase (EC 6.18 36.2 C Unknown + + 1.18.1.2) RB1753 Hypothetical protein 4.50 17.1 P Cytoplasmic + + + + RB9190 Ferredoxin 5.00 14.4 C Cytoplasmic + + + +

1.6.3 Phosphate compounds RB7084 PpaC Probable manganese-dependent inorganic 4.48 61.3 C Unknown + pyrophosphatase (EC 3.6.1.1) RB6302 ADP-ribose pyrophosphatase (EC 3.6.1.13) 4.46 18.9 L Cytoplasmic +

1.6.4 RB9498 ArsA_8 (EC 3.1.6.1) 6.42 58.4 P Unknown 1.00 + + + + + + RB3877 AslA_2 Aryl-sulfate sulphohydrolase (EC 3.1.6.1) 6.36 58.4 P Unknown 1.00 + + + RB973 Mucin-desulfating (N-acetylglucosamine- 5.60 84.8 P Multipe 1.00 + + + + 6-sulfatase) (EC 3.1.6.14) localization sites RB3309 N-acetylgalactosamine 6-sulfatase (GALNS) 5.75 75.4 P Cytoplasmic 1.00 + + RB3403 N-acetylgalactosamine 6-sulfatase (GALNS) 5.79 55.1 P Unknown 1.00 + RB4851 N-acetylgalactosamine 6-sulfatase (GALNS) 7.06 53.9 P Unknown 0.95 + + RB7560 GALNS_1 N-acetylgalactosamine 6-sulfate sulfatase 5.95 59.4 P Unknown + + (GALNS) (EC 3.1.6.4) RB2254 Iduronate-2-sulfatase (EC 3.1.6.13) 7.49 60.8 P Cytoplasmic + + RB3755 Iduronate-2-sulfatase (EC 3.1.6.13) 5.95 52.4 P Multipe 0.99 + + localization sites RB2732 Heparan N-sulfatase (EC 3.1.6.-) 6.13 62.7 P Unknown + + RB7598 Probable alkyl sulfatase or beta-lactamase 9.34 53.5 Q Unknown 1.00 + + RB11502 Alkyl sulfatase or beta-lactamase (EC 3.1.6.-) 6.38 48.6 Q Unknown 1.00 + + RB2367 Probable sulfatase atsD 5.09 86.8 P Multipe 1.00 + + localization sites RB5378 Aryl-sulphate sulphohydrolase 5.20 54.2 P Unknown 1.00 + + RB6873 Arylsulphatase A (EC 3.1.6.8) 5.64 54.4 P Cytoplasmic 0.80 + + RB7995 ArsA_6 Arylsulfatase homolog (EC 3.1.6.8) 7.02 72.5 P Cytoplasmic + +

1.7 Others RB10971 DltE Probable short-chain dehydrogenase 9.45 32.8 R Cytoplasmic + + RB1381 Dys1 Similar to deoxyhypusine synthase (Dhs) 5.77 41.0 O Unknown + + RB8851 HpaG Probable 2-hydroxyhepta-2,4-diene-1,7-dioate 4.18 31.0 R Unknown + + + isomaerase (EC 5.3.3.-) (EC 4.1.1.-) RB8268 MraW S-adenosyl-methyltransferase mraW (EC 2.1.1.-) 5.67 36.5 M Cytoplasmic + + RB7482 RfbE CDP-tyvelose epimerase (EC 5.1.3.-) (EC 4.97 39.0 M Cytoplasmic + + + 4.2.1.46) RB8031 YbhE Hypothetical protein ybhE 6.24 42.3 G Unknown 0.94 + RB11762 StrI Probable streptomycin biosynthesis protein strI 5.59 54.1 R Unknown + + RB4404 Hypothetical oxidoreductase yhxD-putative 4.85 32.8 Q Cytoplasmic + + dehydrogenase of the short-chain dehydrogenase family RB7548 Similar to syringomycin biosynthesis enzyme 2 4.79 31.4 Q Unknown + RB11008 Similar to cycloartenol synthase 5.17 42.9 ++ Unknown 1.00 + + + RB12456 Similar to cyclophilin 11.66 15.5 ++ Unknown + + RB11150 Xenobiotic reductase B 4.48 42.1 C Unknown +

2 Cellular processes 2.1 Electron transport chain RB1831 NqrA Sodium-translocating NADH:ubiquinone 5.32 51.0 C Cytoplasmic + + + oxidoreductase subunit nqrA (EC 1.6.5.-) RB1833 NqrC Sodium-translocating NADH dehydrogenase 4.28 33.0 C Multipe 0.99 + + + (Ubiquinone) subunit nqrC (EC 1.6.5.-) localization sites RB1837 NqrF Na+-translocating NADH:quinone oxidoreductase, 4.69 46.1 C Multipe 0.96 + + + subunit nqrF (EC 1.6.5.-) localization sites RB4399 Quinone oxidoreductase (EC 1.6.5.5) 4.64 35.1 C Unknown + + RB11985 Quinone oxidoreductase (EC 1.6.5.5) 4.57 35.5 C Unknown + + RB11946 Thermophilic NAD(P)H-flavin oxidoreductase 4.58 22.6 C Unknown + RB7223 Trx_3 Thioredoxin reductase (EC 1.6.4.5) 4.78 40.5 O Cytoplasmic + + + RB12160 TrxA_2 Thioredoxin 1 4.11 11.6 O Cytoplasmic + + + RB6384 Probable thioredoxin related protein 4.50 49.6 O Unknown 0.95 + RB8674 Probable thioredoxin 4.85 71.7 O Periplasmic 0.99 + + + RB12541 Probable thioredoxin 4.29 54.2 O Cytoplasmic 1.00 + RB9470 Ppk (EC 2.7.4.1) 6.91 95.7 P Cytoplasmic + + RB9386 FixW Probable FixW protein 4.15 44.6 O Periplasmic 1.00 + + RB2797 Similar to cytochrome c-554 7.26 41.4 ++ Unknown 0.92 + + RB3953 Probable cytochrome oxidase (Cbb3-type) (EC 5.31 93.9 C Cytoplasmic + + 1.9.3.1) RB6350 Probable cytochrome oxidase subunit (Cbb3-type) 6.41 93.9 O Cytoplasmic + + + (EC 1.9.3.1) membrane RB7973 CycA_4 Probable cytochrome c 5.78 155.4 G Unknown + + RB12683 CtaD Cytochrome oxidase subunit I (EC 1.9.3.1) 7.23 64.5 C Cytoplasmic + + + membrane RB12351 Similar to c-type cytochrome 5.05 148.2 ++ Cytoplasmic + + RB13193 AAA superfamily ATPase 8.64 36.2 O Cytoplasmic + + membrane RB7618 Putative electron transport protein ykgF-putative 8.74 53.9 C Cytoplasmic + + 4Fe-4S containing oxidoreductase RB7033 Similar to filamin 5.94 88.9 ++ Unknown + +

2.2 Stress / Detoxification Response RB6751 ClpC Negative regulator of genetic competence 5.16 95.8 O Cytoplasmic + + + + + ClpC/MecB RB10826 ClpP_1 ATP-dependent clp protease proteolytic subunit 4.92 25.1 O Cytoplasmic + + (EC 3.4.21.92) RB10829 ClpP_2 ATP-dependent clp protease proteolytic subunit 5.08 21.8 O Cytoplasmic + + + + (EC 3.4.21.92) RB11179 UspA_1 Hypothetical protein uspA 8.30 38.3 T Cytoplasmic + + + RB11183 UspA_2 Hypothetical protein uspA 4.98 34.9 T Cytoplasmic + RB4438 Probable general stress protein 26 4.39 18.0 R Unknown + + + RB4433 Probable DNA protection during starvation protein 4.29 17.8 P Cytoplasmic + + RB4681 Probable cold shock protein scoF 4.65 7.0 K Cytoplasmic + + + + RB3010 PerA Peroxidase/catalase (EC 1.11.1.6) (Catalase- 5.06 93.6 P Unknown + + peroxidase) RB4376 KatA Catalase (EC 1.11.1.6) 5.82 56.6 P Cytoplasmic + + + RB10727 Manganese-containing catalase 5.00 30.1 P Unknown + + + RB8238 PrdX2 Peroxiredoxin 2 4.57 22.1 O Cytoplasmic + + + + + + RB4586 TPX Probable thiol peroxidase (EC 1.11.1.-) 4.60 18.6 O Unknown + + + RB6688 SodA Superoxide dismutase, Mn family (EC 1.15.1.1) 6.86 24.9 P Unknown + + + + + RB8843 Probable stage V sporulation protein K-putative 4.91 67.3 O Cytoplasmic + + + ATPase of the AAA family RB2968 EngC Probable GTPase engC (EC 3.6.1.-) 7.86 41.9 R Cytoplasmic + + RB6230 IRE Similar to IRE (Iron responsive element) 4.16 74.4 L Unknown 0.99 + + +

2.3 Transport/binding proteins 2.3.1 ABC transporter systems RB1517 LolD1 Lipoprotein releasing system ATP-binding protein 4.93 24.5 V Cytoplasmic + + lolD 1 membrane RB4866 Lipoprotein releasing system ATP-binding protein 6.52 25.6 V Cytoplasmic + lolD membrane RB5055 Uup ABC transporter ATP-binding protein uup-1 5.23 69.4 R Multipe + + + localization sites RB9076 YbiT Hypothetical ABC transporter ATP-binding protein 6.23 71.7 R Cytoplasmic + + ybiT, uup homologs membrane RB8375 ABC transporter - uup homologs 5.06 62.7 R Cytoplasmic + + + + RB279 ABC-type multidrug transport system, ATPase 4.99 34.1 V Cytoplasmic + + + component RB6236 ABC-type multidrug transport system, ATPase 4.79 37.0 V Cytoplasmic + + + component membrane RB7166 ABC-type multidrug transport system, ATPase 5.48 35.1 V Cytoplasmic + + component RB1248 ABC-type multidrug transport system, ATPase 6.06 29.0 V Multipe + + + component localization sites RB1250 ABC-type multidrug transport system, ATPase 5.02 109.3 R Cytoplasmic + + + component membrane RB7215 SphX Phosphate ABC transporter, periplasmic 4.40 34.2 P Unknown + + + phosphate-binding protein RB6469 Sodium ABC transporter ATP-binding protein 5.91 27.7 C Cytoplasmic + + + RB9385 RbsA_4 Putative ATP-binding protein of ribose ABC 4.79 54.6 G Multipe + + transport system localization sites RB3729 ATP-binding subunit of ABC transporter 6.81 43.4 V Cytoplasmic + + membrane RB9992 Probable Fe-S assembly/SufBCD system 6.39 54.4 O Cytoplasmic + + RB9995 Probable Fe-S assembly/SufBCD system 4.64 52.3 O Unknown + + + + RB9998 Probable Fe-S assembly/SufBCD system 6.32 30.6 O Cytoplasmic + + +

2.3.2 ATP synthases RB10206 AtpB_1 Probable protein ATP synthase A chain (EC 5.92 38.2 C Cytoplasmic + + 3.6.3.14) membrane RB10215 AtpA_2 Protein ATP synthase alpha chain (EC 3.6.3.14) 4.74 54.2 C Unknown + + + + + + RB10217 AtpB_3 H+-transporting ATP synthase beta chain (EC 4.84 52.2 C Unknown + + + + + + 3.6.1.34) RB10213 AtpD_2 Probable ATP synthase delta chain (EC 3.6.3.14) 8.23 24.5 C Cytoplasmic + + + RB10209 AtpE_1 Similar to H+-transporting ATP synthase C chain 10.23 11.6 C Unknown + + + (EC 3.6.3.14) RB10219 AtpE_2 Probable ATP synthase CF1 subunit e (EC 4.61 14.0 C Cytoplasmic + + 3.6.3.14) RB10211 AtpF_1 Probable protein ATP synthase B chain (EC 4.52 27.9 C Unknown 0.97 + + 3.6.3.14) RB10216 AtpG_2 ATP synthase gamma chain 6.15 32.7 C Cytoplasmic + + + +

2.3.3 Phosphotransferase System (PTS) RB8591 PtsI Phosphoenolpyruvate-protein phosphotransferase 5.30 66.9 G Cytoplasmic + + + (EC 2.7.3.9) RB5795 PtsN Probable PTS system, fructose-specific IIABC 4.89 26.1 G Cytoplasmic + + + component (EC 2.7.1.69) RB8584 FruA PTS system, fructose-specific enzyme II, BC 4.46 17.4 G Cytoplasmic + + + + component (EC 2.7.1.69)

2.3.4 Secondary Transporters RB6538 Sodium/glucose cotransporter 6.15 63.6 R Cytoplasmic + + membrane RB297 AmtB Ammonium transporter P Cytoplasmic + + membrane RB10984 AcrD Probable RND efflux transporter 4.57 122.1 V Cytoplasmic 0.95 + + membrane RB11154 Probable RND efflux membrane fusion protein 4.29 48.5 M Cytoplasmic 0.99 + + membrane RB4870 Predicted cation efflux system (AcrB/AcrD/AcrF 4.96 116.2 V Cytoplasmic + + family) membrane RB4879 Nodulin-26 4.83 58.1 G Cytoplasmic + + membrane RB8240 OxaA Inner membrane protein oxaA 4.86 90.6 U Cytoplasmic + + + membrane RB4633 SecD Protein-export membrane protein secD 4.27 118.5 U Cytoplasmic + + + membrane RB3185 Probable integral membrane protein 4.88 142.3 R Cytoplasmic 0.85 + + membrane RB2386 MexA Multidrug resistance protein MexA 6.47 59.0 M Cytoplasmic + + + membrane RB2383 MexB Similar to multidrug resistance protein MexB 4.84 124.9 V Cytoplasmic 0.96 + + membrane

2.3.5 Others RB3482 General secretion pathway protein E 4.93 62.2 N Cytoplasmic + + RB10227 HofB General secretion pathway protein E 8.62 49.2 N Cytoplasmic + + + + RB8113 Probable ABC-type transport system ATP-binding 5.96 33.9 V Cytoplasmic + + protein membrane RB11294 Probable general secretion pathway protein E 4.63 140.6 N Periplasmic + + RB1566 ComQ Similar to general secretory pathway protein D 4.80 127.0 N Outer + + + membrane RB7210 PhoU Phosphate transport system protein PHOU 4.55 26.3 P Cytoplasmic + + + homolog RB8035 TrkA TRK potassium uptake system protein (TrkA-2) 4.87 48.0 P Cytoplasmic + + + RB9313 Probable copper efflux system protein cusB 4.93 41.4 M Multipe 1.00 + + (Precursor) localization sites RB8565 IolI Similar to IolI protein 4.36 33.6 G Cytoplasmic + + + + + RB9367 IolI Probable IolI protein 4.93 36.0 G Unknown 1.00 + RB6120 TolB_1 Probable TolB protein 4.61 116.8 R Outer 1.00 + membrane RB861 TolQ_1 Probable biopolymer transport protein 5.95 54.0 U Cytoplasmic + + membrane RB10700 TolQ_4 Probable TolQ 4.78 25.7 U Cytoplasmic + + membrane RB10709 Dipeptide-binding protein (DBP)-putative secreted, 5.41 89.5 E Multipe 1.00 + membrane associated or paryphoplasmic protein localization sites RB4532 Similar to MchE protein 5.55 56.2 M Cytoplasmic 0.99 + +

2.4 Mobility structures RB5172 CpaB Probable pilus assembly protein CpaB 4.54 43.8 U Unknown + + + RB12768 PilB_1 Type IV fimbrial assembly protein PilB 7.46 78.2 N Cytoplasmic + + + RB12774 PilB_2 Type IV fimbrial assembly protein PilB 4.24 66.5 N Cytoplasmic + RB10228 PilT_1 Twitching motility protein PilT 6.03 44.2 N Cytoplasmic + + + RB12773 PilT_2 Twitching mobility protein PilT 6.75 40.6 N Cytoplasmic + + + RB2860 PilM Probable fimbrial assembly protein PilM 4.47 80.8 N Cytoplasmic + + RB3742 FliC_1 Flagellin E 4.08 72.0 N Cytoplasmic + + + + RB4454 FliC_2 Flagellin 4.08 76.9 N Extracellular + + RB6996 FliC_3 Flagellin 3.64 69.9 N Extracellular + + RB3453 FliD Probable lateral flagellar hook-associated protein 2 3.95 82.1 N Extracellular + + +

RB12502 FliG Flagellar motor switch protein FliG 7.39 47.0 N Cytoplasmic + +

2.5 Cell wall and outer membrane binding proteins RB10503 Probable lipopolysaccharide biosynthesis protein 6.79 49.5 R Unknown + + + BplA-putative NADH-dependent oxidoreductase RB10404 Similar to polysaccharide biosynthesis protein 5.69 50.6 M Cytoplasmic 0.94 + + RB2661 MurB UDP-N-acetylenolpyruvoylglucosamine reductase 6.11 36.9 M Unknown + + (EC 1.1.1.158) RB997 Ogt_1 Probable O-linked GlcNAc transferase (EC 2.4.1.-) 4.32 56.5 R Cytoplasmic + + RB3733 DTDP-glucose 4-6-dehydratase (EC 4.2.1.46) 7.31 38.0 M Cytoplasmic + + RB6383 MdoG Periplasmic glucans biosynthesis protein MdoG 4.23 63.9 P Periplasmic 0.99 + + + RB6807 Sialic acid-specific 9-O-acetylesterase ++ Unknown 0.99 + RB10048 Sialic acid-specific 9-O-acetylesterase (EC 4.80 60.1 ++ Unknown + + 3.1.1.53) RB1527 Pa1G Probable platelet-activating factor acetylhydrolase 6.15 29.1 E Unknown 1.00 + + IB gamma subunit (EC 3.1.1.47) RB10478 Probable AcrA/AcrE family protein-putative 4.66 35.8 M Multipe 0.99 + secreted protein localization sites RB6428 Hypothetical fascilin protein 6.97 17.3 M Unknown 0.99 + + + + RB7455 Hypothetical protein containing YTV domains 7.90 92.2 ++ Unknown + + + + RB2247 Hypothetical protein containing YTV domains 8.77 65.0 R Unknown 1.00 + + + RB850 Hypothetical protein containing YTV domains 7.52 65.9 ++ Unknown + + + RB5223 Probable merozoite surface protein 3b 4.78 48.5 N Cytoplasmic + + + + + RB7341 Similar to surface-associated protein cshA 3.83 796.6 U Multipe + + + localization sites RB844 Probable surface-associated protein cshA 3.55 158.6 Q Multipe + + localization sites RB10981 MtrC Probable membrane fusion protein mtrC 4.44 66.4 M Unknown + + RB5921 Similar to surface protein 5.78 91.5 ++ Unknown 1.00 + + RB577 Probable polymorphic membrane protein B/C 4.15 73.2 U Multipe + + family localization sites

2.5 Cell division RB4173 FtsY Cell division protein FtsY 5.73 35.9 U Multipe + + + + localization sites RB2966 Cell division protein FtsH (EC 3.4.24.-) 5.61 74.4 O Cytoplasmic + + membrane

3 Genetic Information Processing 3.1 DNA replication 3.1.1 DNA and /recombinases RB3157 Y4QK Probable /recombinase 10.07 51.8 L Cytoplasmic + + RB7399 Y4QK Putative integrase/recombinase 10.71 52.5 L Unknown + + RB12202 Probable integrase-recombinase protein 9.85 60.7 L Unknown + + RB6065 Smc Chromosome partition protein 5.67 136.6 D Cytoplasmic + + + RB8870 Mrp protein homolog-putative ATPase involved in 5.44 39.4 D Cytoplasmic + + chromosome partitioning RB11863 RecA RecA protein (Recombinase A) 5.57 39.9 L Unknown + + +

3.1.2 DNA replication initiation RB13225 RecQ_2 ATP-dependent DNA RecQ (EC 3.6.1.-) 8.56 61.7 L Cytoplasmic + + RB4610 RuvA Probable holliday junction DNA helicase 6.55 22.7 L Unknown + + RB8062 YoaA ATP-dependent helicase, DinG family 8.22 78.8 K Unknown + + + RB12363 PcrA_1 ATP-dependent DNA helicase (EC 3.6.1.-) 5.35 88.8 L Unknown + + RB4247 HrpA ATP-dependent helicase 6.82 154.2 L Cytoplasmic + + + RB4013 HrpB ATP-dependent helicase 6.44 93.5 L Cytoplasmic + + RB9344 Probable swi/snf family helicase 2 5.99 153.9 K Unknown + + RB8 Helicase 5.22 129.9 K Cytoplasmic + + RB3465 GyrA_1 DNA gyrase subunit A (EC 5.99.1.3) 9.25 90.8 L Cytoplasmic + + + RB8841 GyrA_2 DNA gyrase subunit A 5.11 108.9 L Unknown + + + RB9109 GyrB_3 DNA gyrase subunit B (EC 5.99.1.3) 4.86 98.6 L Cytoplasmic + + + RB9917 Ssb Single-strand binding protein (SSB) 5.33 18.1 L Unknown + RB3281 Hup Probable DNA-binding protein HU 7.55 15.8 L Cytoplasmic + + + RB6276 Hup Probable DNA-binding protein HU 10.64 11.3 L Unknown + + +

3.1.3 DNA RB10108 DnaN DNA III, beta chain (EC 2.7.7.7) 4.80 48.6 L Cytoplasmic + + RB12799 PolA DNA polymerase I (EC 2.7.7.7) 4.56 112.8 L Cytoplasmic + + RB1485 PolB DNA polymerase beta family (EC 2.7.7.7) 4.82 65.0 L Cytoplasmic + RB7610 YshC Similar to DNA-dependent DNA polymerase beta 5.98 47.7 E Multipe 0.99 + + + chain localization sites

3.1.4 DNA restriction/modification and repair RB10711 LigA_1 DNA ligase (EC 6.5.1.2) 4.81 78.3 L Cytoplasmic + + RB11371 HsdR_2 HsdR (EC 3.1.21.3) 5.81 130.9 V Cytoplasmic + + + RB10768 HsdM_1 Type I StySPI M protein (EC 4.81 56.1 V Unknown + + + 2.1.1.72) RB7237 MutS DNA mismatch repair protein 5.30 97.9 L Cytoplasmic + + RB8161 ExoA (EC 3.1.11.2) 6.10 29.7 L Cytoplasmic + + RB7959 UvrA_2 Exinuclease ABC subunit A 5.59 241.8 L Multipe + + + localization sites RB8397 UvrB UvrABC system protein B (Excinuclease ABC 6.48 80.3 L Cytoplasmic + + subunit B) (UvrB protein) RB2619 YabD Putative (EC 3.1.21.-) 4.54 30.6 L Cytoplasmic + + RB1386 Similar to nucleoside hydrolase (EC 3.2.2.1) 4.88 38.4 F Unknown 0.99 + + RB4654 Hypothetical protein 4.49 37.7 G Cytoplasmic + + +

3.2 RNA biosynthesis 3.2.1 Sigma factors RB6491 RNA polymerase subunit sigma-54 4.57 60.2 K Cytoplasmic + + RB4165 AlgU RNA polymerase sigma-H factor 4.47 78.0 K Unknown + + + RB8316 WhiG RNA polymerase sigma factor 5.33 31.3 K Cytoplasmic + + + RB6780 Sigma-70 factor 9.73 64.8 K Cytoplasmic + + + + RB6823 Transcription initiation factor sigma 70 9.69 65.7 K Cytoplasmic + + RB12372 RNA polymerase ECF-type sigma factor 5.68 27.5 K Unknown + + + RB10339 RpdD RNA polymerase sigma factor rpoD 10.12 60.4 K Cytoplasmic + + +

3.2.2 Regulation and Signal Transduction 3.2.2.1 Sigma 54-dependent Enhancer Binding Proteins RB2396 AtoC_1 Acetoacetate metabolism regulatory protein 6.51 53.9 T Cytoplasmic + + RB2731 Acetoacetate metabolism regulatory protein 6.52 54.9 T Cytoplasmic + + RB10323 AtoC_4 Acetoacetate metabolism regulatory protein 5.79 50.4 T Cytoplasmic + + RB12108 Probable response regulatory protein (AtoC) 4.91 54.3 T Cytoplasmic + + RB4487 NtrC_1 assimilation regulatory protein 4.58 56.2 T Cytoplasmic + + RB8745 Nitrogen fixation protein anfA (Sigma-54 6.04 70.1 T Cytoplasmic + + + dependendent transcription regulator containing a GAF and a FHA domains) RB8580 Probable sigma-54 modulation protein 6.15 12.7 J Cytoplasmic + + + + + RB2743 Nitrate/nitrite regulatory protein narP 6.13 23.0 T Cytoplasmic + + + + + + RB321 Response regulator 5.17 27.8 T Cytoplasmic + + + + RB6403 Probable response regulator 5.59 33.7 T Cytoplasmic + +

3.2.2.2 MoxR-related transcriptional regulatory proteins RB1798 MoxR_2 Methanol dehydrogenase regulator (MoxR) 4.57 40.6 R Cytoplasmic + + + homolog RB4081 MoxR_3 Probable regulatory protein 4.55 41.6 R Cytoplasmic + RB6056 MoxR_4 Putative moxR-like transcriptional regulator protein 5.16 40.0 R Cytoplasmic + + + RB8173 MoxR_6 Probable MoxR-related protein 5.11 37.6 R Cytoplasmic + + RB8983 MoxR_7 Hypothetical protein moxR 4.75 38.0 R Cytoplasmic + + + RB9108 MoxR_8 MoxR-related protein 4.95 39.7 R Cytoplasmic + RB9499 MoxR_9 MoxR-related protein 5.98 41.8 R Cytoplasmic + + + RB10517 YeaC Methanol dehydrogenase regulation homolog 4.53 34.3 R Cytoplasmic + RB6603 Methanol dehydrogenase regulatory protein 4.94 37.7 R Cytoplasmic + + (MoxR) RB8768 MoxR-type regulator 4.78 38.2 R Cytoplasmic + +

3.2.2.3 Regulatory proteins RB2975 GlnB_2 Nitrogen regulatory protein P-II 8.48 14.9 E Cytoplasmic + + + RB9431 CheY_3 Two-component system response regulator 7.00 26.9 T Cytoplasmic + + RB10491 CheY_3 Probable two-component system regulatory 4.55 35.5 T Cytoplasmic + protein RB11260 DksA_2 Probable dnaK (DksA-like) supressor protein 5.27 13.6 T Cytoplasmic + + RB5778 PhoA Probable alkaline (EC 3.1.3.1) 5.13 69.0 P Periplasmic + + RB4136 PhoB Probable regulatory components of sensory 4.39 16.1 T Cytoplasmic + + + transduction system RB7437 LexA_2 LexA protein (EC 3.4.21.88) 9.88 25.9 K Cytoplasmic + + RB4582 PhoH-like protein 5.37 41.0 T Cytoplasmic + + RB8796 Probable gntR-family transcription regulator 6.44 25.9 K Unknown + + RB7395 Similar to SP1 11.87 15.2 ++ Cytoplasmic + + RB6087 Similar to response regulator 4.64 13.8 T Cytoplasmic + + RB6217 Putative response regulator 4.22 15.9 T Cytoplasmic + + RB1321 Probable transcription repressor 5.01 34.2 K Multipe + localization sites RB1743 Probable transcription regulator 6.26 38.8 K Cytoplasmic + + + RB2680 Similar to suppressor for copper-sensitivity C 6.82 49.8 O Cytoplasmic 0.94 + + membrane RB1140 Response regulator 6.12 23.7 T Cytoplasmic + + RB10793 Probable two-component response regulator 6.10 70.7 T Cytoplasmic + + RB1483 Probable sensor /response 5.02 29.2 T Unknown + regulator (EC 2.7.3.-) RB10330 Sensory transduction histidine kinase-possibly 4.94 94.9 T Cytoplasmic + + sensor/response regulator hybrid (EC 2.7.3.-) membrane

3.2.2.4 Sensor RB641 Sensory histidine protein kinase 5.09 132.0 T Cytoplasmic + + + membrane RB4759 Sensor protein fixL 6.81 46.0 T Cytoplasmic + + membrane RB1821 PknB_4 Probable serine/threonine-protein kinase (EC 5.41 88.4 R Cytoplasmic + + 2.7.1.-) RB5028 Probable serine/threonine-protein kinase pknB 5.25 203.5 R Cytoplasmic + + membrane RB5731 Serine/threonine protein kinase (EC 2.7.1.-) 6.71 59.6 R Cytoplasmic + + membrane RB6486 Probable serine/threonine protein kinase related 4.39 49.0 S Unknown 0.93 + protein RB7541 Similar to serine/threonine protein kinase related 4.24 75.1 S Unknown 0.97 + + protein RB9110 Similar to serine/threonine protein kinase related 4.68 63.3 S Unknown + protein RB10367 Probable serine/threonine protein kinase (EC 6.38 120.1 R Cytoplasmic + + 2.7.1.-) membrane RB10706 Similar to serine/threonine protein kinase related 4.30 122.9 S Unknown + + protein-putative PQQ-dependent oxidoreductase RB11660 Probable serine/threonine protein kinase related 4.65 80.9 S Unknown 0.99 + protein RB12303 Probable serine/threonine protein kinase related 4.54 66.6 S Unknown 0.91 + + protein

3.2.3 RNA polymerases RB1964 RpoA_1 Probable DNA-directed RNA polymerase alpha 4.67 55.6 K Cytoplasmic + + + + chain (EC 2.7.7.6) RB12626 RpoA_3 DNA-directed RNA polymerase alpha chain (EC 4.91 36.8 K Cytoplasmic + + + + + + 2.7.7.6) RB5414 RpoB DNA-directed RNA polymerase beta chain (EC 5.02 140.3 K Cytoplasmic + + + + 2.7.7.6) RB5416 RpoC DNA-directed RNA polymerase beta' chain (EC 6.82 159.2 K Cytoplasmic + + + 2.7.7.6) RB7088 RpoZ DNA-directed RNA polymerase omega chain (EC 4.08 10.1 K Cytoplasmic + + 2.7.7.6) RB818 /maturase (EC 2.7.7.49) 10.23 53.1 L Cytoplasmic + +

3.2.4 Transcription elongation and termination RB2780 GreA Transcription elongation factor 4.37 17.7 K Cytoplasmic + + + + + RB10458 Grp RNA-binding protein 10.32 21.1 R Unknown + + + + + + RB5507 NusA Transcription terminator protein A 4.00 54.0 K Cytoplasmic + + + + + RB7898 NusG Transcription antiterminator 4.08 25.1 K Unknown + + + RB4997 Rho_1 Probable transcription termination factor 6.34 57.9 K Cytoplasmic + + RB8777 Rho_2 Probable transcription termination factor rho 9.52 48.4 K Cytoplasmic + + +

3.2.5 RNA modification and RB5804 Pnp_2 Polyribonucleotide (EC 5.38 88.2 J Cytoplasmic + + + + + 2.7.7.8) RB9359 RtcA RNA 3-terminal phosphate cyclase (RNA-3- 7.89 38.4 A Cytoplasmic + + phosphate cyclase) (EC 6.5.1.4) membrane RB11230 Bfr Bacterioferritin 4.34 18.1 P Cytoplasmic + + RB9401 MiaB Putative tRNA-thiotransferase 6.52 53.3 J Cytoplasmic + + + RB8328 CMP-binding protein 5.97 35.6 R Cytoplasmic + + + RB6391 Rbn Probable ribonuclease BN (EC 3.1.-.-) 4.30 63.4 S Cytoplasmic + + membrane RB8595 Rne Ribonuclease E (EC 3.1.4.-) 8.10 61.0 J Cytoplasmic + + + RB5725 Rph Ribonuclease PH (EC 2.7.7.56) 4.59 26.3 J Unknown + + + RB9360 RtcB Hypothetical protein rtcB 6.95 55.2 S Cytoplasmic + +

3.3 Protein synthesis 3.3.1 Translation initiation and elongation factors RB5504 InfB Translation initiation factor IF-2 8.60 110.1 J Multipe + + localization sites RB1213 Efp_1 Elongation factor P (EF-P) 4.50 21.7 J Cytoplasmic + + + + + RB12577 Efp_2 Translation elongation factor EF-P 5.75 28.4 J Cytoplasmic + + RB5434 FusA_1 Elongation factor G (EF-G) 4.69 77.8 J Cytoplasmic + + + + RB7821 FusA_2 Elongation factor G 4.70 79.7 J Cytoplasmic 0.96 + + + RB10640 Tsf Elongation factor Ts (EF-Ts) 4.60 35.8 J Cytoplasmic + + + + + + RB7894 TufA Translational elongation factor-Tu 5.34 43.2 J Cytoplasmic + + + + + RB6466 TypA GTP-binding translation elongation factor homolog 5.12 70.4 T Cytoplasmic + + + + RB1270 Putative translation initiation inhibitor 4.96 16.5 J Cytoplasmic + + RB6395 Probable PKR inhibitor (Translation regulation) 4.57 85.7 R Unknown + + +

3.3.2 Translation termination RB3886 Frr Ribosome recycling factor (Ribosome releasing 4.65 22.2 J Cytoplasmic + + + factor) (RRF) RB5503 RbfA Ribosome-binding factor A 5.05 15.3 J Cytoplasmic + + + RB9305 PrfA Peptide chain release factor 1 4.84 40.8 J Cytoplasmic + + + RB6552 PrfB Peptide chain release factor 2 (RF-2) 4.58 37.7 J Cytoplasmic + +

3.3.3 Ribosomal proteins 3.3.3.1 Large subunit RB6482 RluD_2 Ribosomal large subunit pseudouridine synthase D 9.71 28.5 J Unknown + +

RB12839 RplA 50S ribosomal protein L1 9.76 24.2 J Unknown + + + + + RB7837 RplB 50S ribosomal protein L2 11.81 31.1 J Unknown + + + + + RB7833 RplC 50S ribosomal protein L3 11.13 24.7 J Unknown + + + + + RB7834 RplD 50S ribosomal protein L4 10.89 24.3 J Unknown + + + + + RB7852 RplE 50S ribosomal protein L5 10.53 22.2 J Cytoplasmic + + + + RB7856 RplF 50S ribosomal protein L6 10.07 19.7 J Unknown + + + + + RB9916 RplI Ribosomal protein L9 6.87 19.4 J Cytoplasmic + + + + + + + RB12840 RplJ Probable 50S ribosomal protein L10 4.92 18.8 J Unknown + + + RB7899 RplK 50S ribosomal protein L11 9.54 15.1 J Unknown + + + + + RB12842 RplL Probable 50S ribosomal protein L7/L12 4.29 14.5 J Unknown + + + + + + RB10471 RplM 50S ribosomal protein L13 9.62 17.4 J Cytoplasmic + + + RB7850 RplN 50S ribosomal protein L14 11.14 13.5 J Unknown + + + RB7841 RplP 50S ribosomal protein L16 11.25 15.3 J Unknown + + + RB12628 RplQ Probable 50S ribosomal protein L17 10.39 23.7 J Cytoplasmic + + + + + + RB7857 RplR 50S ribosomal protein L18 11.73 16.6 J Unknown + + + + RB12821 RplS 50S ribosomal protein L19 11.27 13.3 J Unknown + + + + RB10134 RplU 50S ribosomal protein L21 10.19 11.7 J Unknown + + + + RB7839 RplV 50S ribosomal protein L22 11.16 13.5 J Unknown + + + RB7851 RplX 50S ribosomal protein L24 10.80 12.5 J Cytoplasmic + + + RB9923 RplY Probable 50S ribosomal protein L25 4.44 22.8 J Cytoplasmic + + + + RB7846 RpmC Probable 50S ribosomal protein L29 10,48 8.3 J Unknown + + +

RB9304 RpmE 50S ribosomal protein L31 9.96 9.1 J Unknown + +

3.3.3.2 Small subunit RB2024 RpsA_1 30S ribosomal protein S1 5.03 59.8 J Cytoplasmic + + + + RB2543 RpsA_2 30S ribosomal protein S1 4.41 76.5 J Cytoplasmic + + + + RB10638 RspB Ribosomal protein S2 9.14 44.0 J Unknown + + + + RB7840 RpsC 30S ribosomal protein S3 10.63 26.6 J Unknown + + RB1233 RpsD 30S ribosomal protein S4 11.33 23.2 J Cytoplasmic + + + + + + RB7859 RpsE 30S ribosomal protein S5 10.64 18.8 J Cytoplasmic + + + + RB9920 RpsF Probable ribosomal protein S6 4.27 15.5 J Cytoplasmic + + + + + RB7820 RpsG 30S ribosomal protein S7 10.43 17.7 J Unknown + + + RB7855 RpsH_2 30S ribosomal protein S8 10.55 15.2 J Cytoplasmic + + + + RB10469 RpsI 30S ribosomal protein S9 11.23 15.0 J Cytoplasmic + + + + RB7829 RpsJ 30S ribosomal protein S10 10.52 12.0 J Unknown + + + + RB12625 RpsK 30S ribosomal protein S11 11.53 13.6 J Unknown + + + RB7818 RpsL 30S ribosomal protein S12 11.91 13.6 J Unknown + + + + RB12623 RpsM 30S ribosomal protein S13 10.95 14.5 J Unknown + + + + RB5801 RpsO Probable 30S ribosomal protein S15 10.74 10.2 J Cytoplasmic + + RB12824 RpsP 30S ribosomal protein S16 5.35 15.9 J Unknown + + + + + RB7849 RpsQ Probable 30S ribosomal protein S17 10.14 12.1 J Cytoplasmic + + + + RB7022 RpsT 30S ribosomal protein S20 12.33 10.2 J Cytoplasmic + +

3.3.4 Protein folding and targeting RB9103 ClpB Chaperone clpB 4.83 99.5 O Cytoplasmic + RB5681 Tig Trigger factor (TF) 4.44 66.6 O Cytoplasmic + + + + + + RB5754 Dnak_2 Probable chaperone protein DnaK 4.53 70.2 O Cytoplasmic + RB9105 DnaK_4 Chaperone protein dnaK (Heat shock 70 kDa 4.56 76.1 O Unknown + + + + + + protein) (HSP70) RB10242 DnaJ_1 DnaJ1 protein 7.10 35.2 O Cytoplasmic + + RB8974 GrpE GrpE protein (HSP-70 cofactor) 4.20 21.9 O Cytoplasmic + + + + RB8966 GroEL_1 60 kDa chaperonin 5.29 69.8 O Cytoplasmic + + + + + + RB8970 GroEL_2 60 kDa chaperonin 4.80 57.5 O Cytoplasmic + + + + + + RB10629 GroEL_3 60 kDa chaperonin 4.87 57.5 O Cytoplasmic + + + + + + RB8969 GroES_2 10 kDa chaperonin 4.87 10.6 O Cytoplasmic + + + + + RB10627 GroES_3 10 kDa chaperonin 3.99 10.0 O Cytoplasmic + + + + + RB10283 Hsp2 _2 Heat shock protein SP21 4.65 12.3 O Cytoplasmic + + RB11626 Similar to preprotein SecA chain 8.96 57.6 U Cytoplasmic + + RB11690 SecA_3 Preprotein translocase SecA subunit 4.87 139.8 U Cytoplasmic + + + + + RB7866 SecY Preprotein translocase secY subunit 9.71 50.9 U Cytoplasmic + + + membrane

3.3.5 Aminoacyl-tRNA sythetases RB9134 TyrS Tyrosyl-tRNA synthetase (EC 6.1.1.1) 5.03 48.7 J Cytoplasmic + + + RB6436 TrpS Tryptophanyl-tRNA synthetase (EC 6.1.1.2) 5.69 35.5 J Cytoplasmic + RB12129 ThrS Threonyl-tRNA synthetase (EC 6.1.1.3) 5.95 92.9 J Cytoplasmic + + + RB8919 LeuS Leucyl-tRNA synthetase (EC 6.1.1.4) 5.05 107.1 J Cytoplasmic + + + RB7259 IleS Probable isoleucyl-tRNA synthetase (EC 6.1.1.5) 4.93 137.2 J Cytoplasmic + + RB10883 LysS Lysyl-tRNA synthetase (EC 6.1.1.6) 4.65 61.7 J Multipe 0.95 + + + localization sites RB8543 AlaS Alanyl-tRNA synthetase (EC 6.1.1.7) 5.06 104.0 J Cytoplasmic + + + + RB1319 ValS Valyl-tRNA synthetase (EC 6.1.1.9) 4.71 116.6 J Cytoplasmic + + + RB5543 MetG Methionyl-tRNA synthetase (EC 6.1.1.10) 4.70 75.7 J Cytoplasmic + + + + RB12854 Fmt Methionyl-tRNA formyltransferase (EC 2.1.2.9) 6.18 36.0 J Cytoplasmic + RB1039 SerS Seryl-tRNA synthetase (EC 6.1.1.11) 4.99 48.8 J Cytoplasmic + + RB8253 AspS Aspartyl-tRNA synthetase (EC 6.1.1.12) 4.85 66.2 J Cytoplasmic + + + RB10547 GlyS Glycyl-tRNA synthetase (EC 6.1.1.14) 5.87 63.8 J Cytoplasmic + + + RB5178 ProS Prolyl tRNA synthetase (EC 6.1.1.15) 5.22 57.2 J Cytoplasmic + + RB4675 CysS Cysteinyl-tRNA synthetase (EC 6.1.1.16) 6.96 68.5 J Cytoplasmic + RB5747 ArgS Arginyl-tRNA synthetase (EC 6.1.1.19) 5.14 74.4 J Cytoplasmic + + RB7600 GltX Glutamyl-tRNA synthetase (EC 6.1.1.17) 5.09 60.2 J Cytoplasmic + + + + RB1578 GlnS Glutaminyl-tRNA synthetase (EC 6.1.1.18) 6.44 68.7 J Cytoplasmic + + + RB7114 PheS Phenylalanyl-tRNA synthetase alpha chain (EC 4.69 38.0 J Cytoplasmic + + 6.1.1.20) RB7112 PheT Phenylalanyl-tRNA synthetase beta chain (EC 4.73 74.1 J Cytoplasmic + + 6.1.1.20) RB251 HisS Histidyl-tRNA synthetase (EC 6.1.1.21) 4.76 47.7 J Cytoplasmic + + RB13263 AsnS Asparaginyl-tRNA synthetase (EC 6.1.1.22) 5.67 55.9 J Cytoplasmic + + + + RB4143 GatA Glutamyl-tRNA(Gln) amidotransferase subunit A 4.52 52.3 J Unknown + (EC 6.3.5.-) RB10852 GatB Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase 4.64 55.2 J Cytoplasmic + + subunit B (EC 6.3.5.-)

4. Conserved Hypothetical Proteins 4.1 RB9584 Ripening-induced protein-putative Zn-containing 4.95 34.2 C Unknown + + oxidoreductase RB5140 Probable NADH-dependent dehydrogenase 5.72 67.6 R Periplasmic + + + + RB1555 Probable NADH-dependent dehydrogenase 6.13 52.2 R Unknown 1.00 + + + + + + RB5365 Probable NADH-dependent dehydrogenase 6.59 51.7 R Unknown 0.99 + + + + RB6985 Probable NADH-dependent dehydrogenase 7.71 56.1 R Unknown + + + + RB8799 Probable NADH-dependent dyhydrogenase 6.41 51.8 R Unknown + RB9026 Probable NADH-dependent dyhydrogenase 7.55 52.8 R Unknown + + + RB9971 Probable NADH-dependent dyhydrogenase 6.97 50.7 R Unknown 0.99 + + + + RB6199 Dehydrogenase homolog 5.45 40.9 R Periplasmic 0.76 + + RB12038 Hypothetical protein (EC 1.-.-.-) 5.55 42.3 R Multipe + + + + localization sites RB4432 Putative oxidoreductase of the short-chain 4.74 28.2 Q Cytoplasmic 0.93 + + dehydrogenase family RB1939 Probable oxidoreductase 6.35 55.1 R Cytoplasmic + + + + RB2242 Oxidoreductase, short-chain 6.03 26.1 Q Cytoplasmic + + dehydrogenase/reductase family RB5701 Putative oxidase 8.15 122.1 C Cytoplasmic + + RB7193 Putative oxidoreductase 5.70 41.3 R Cytoplasmic + + RB8728 Putative oxidoreductase 5.06 27.7 Q Cytoplasmic + + + + RB2656 Probable oxidoreductase 4.34 37.8 R Unknown 0.99 + + RB6858 Hypothetical oxidoreductase 5.83 36.7 R Unknown 0.99 + + RB10967 Putative oxidoreductase (EC 1.-.-.-) 4.56 37.4 R Unknown + + +

4.2 RB13257 Probable oxidoreductase-putative hydrolase 4.60 32.5 R Unknown + + involved in aromatic ring cleavage (EC 3.7.1.-) (EC 3.1.1.-) RB3405 Putative hydrolase (EC 3.2.1.23) 4.96 86.1 G Unknown 1.00 + + + RB3635 Probable secreted glycosyl hydrolase 4.70 47.8 ++ Multipe 1.00 + + localization sites RB6615 Probable secreted glycosyl hydrolase 5.16 25.8 C Cytoplasmic 0.99 + + + RB9196 Probable secreted glycosyl hydrolase 5.62 50.5 ++ Unknown 0.99 + + + + RB5332 Probable phosphoesterase (EC 3.1.-.-) 4.46 22.2 R Cytoplasmic + RB10907 Probable phosphoesterase PH1616 (EC 3.1.-.-) 4.55 28.6 T Cytoplasmic + + RB10905 Probable phosphoesterase PH1616 (EC 3.1.-.-) 4.67 28.2 T Unknown + + + RB1044 Hypothetical protein putative metal-dependent 5.37 30.7 R Cytoplasmic + + hydrolases RB12347 Similar to hydrolase 5.99 35.9 R Cytoplasmic + +

4.3 Other enzymatic proteins RB10652 Probable C-methyltransferase (EC 2.1.1.-) 4.25 36.7 Q Cytoplasmic + RB11728 Hypothetical protein (EC 5.3.1.-) 4.55 32.4 G Cytoplasmic + + + +

4.4 Others RB5697 Probable thiol-disulfide interchange protein 4.09 51.1 O Cytoplasmic + RB5824 Predicted GTPase 10.53 36.9 R Cytoplasmic + + RB2630 GTP-binding protein OBG 6.31 45.3 R Cytoplasmic + + + RB5186 Probable GTP-binding protein 4.63 42.3 J Cytoplasmic + RB5500 Hypothetical UPF0082 protein RB5500 4.29 26.5 S Cytoplasmic + + + RB4474 Hypothetical UPF0337 protein RB4474 8.22 18.5 S Unknown + + + + RB10934 Hypothetical UPF0337 protein RB10934 4.32 7.9 S Cytoplasmic + + RB4405 Probable DNA-binding protein 4.28 13.7 ++ Cytoplasmic + + RB1563 Similar to DOF zinc finger protein 9.16 14.9 ++ Cytoplasmic + + RB479 Similar to FKBP-rapamycin associated protein 4.90 123.3 ++ Unknown 0.99 + + RB3794 Conserved hypothetical ATP-binding protein 6.05 155.6 D Cytoplasmic + + HP0066 RB444 Putative ATP-binding protein 5.70 56.9 E Cytoplasmic + + RB6566 Similar to protein BmrU 9.63 35.6 I Unknown + + RB11701 Probable tetratricopeptide repeat family protein 5.10 100.3 R Cytoplasmic + + RB1109 Putative multi-domain protein 4.89 29.7 ++ Unknown 1.00 + + RB10823 Hypothetical protein-transmembrane region and 4.97 29.0 E Unknown 0.99 + + signal peptide prediction RB2912 Similar to lipoprotein 4.37 33.5 S Unknown 0.98 + + RB9201 Conserved Hypothetical protein 5.29 229.4 R Extracellular 0.99 + + RB365 Conserved Hypothetical protein 4.84 61.3 G Outer 1.00 + + + membrane RB4703 Conserved Hypothetical protein 5.23 78.1 ++ Outer 1.00 + + membrane RB282 Conserved Hypothetical protein 7.35 37.5 R Cytoplasmic 0.98 + + membrane RB6330 Probable integral membrane protein 4.61 32.5 ++ Unknown 0.98 + + RB9438 Probable large, multifunctional secreted protein 4.58 54.1 ++ Unknown 1.00 + RB8246 Probable transmembrane protein 6.43 29.6 S Unknown 0.99 + + + + RB12543 Conserved Hypothetical protein 9.46 37.6 ++ Cytoplasmic 0.99 + + membrane RB2647 Conserved Hypothetical protein 4.92 27.9 C Multipe 1.00 + + + + + + localization sites RB4500 Conserved Hypothetical protein 3.67 9.4 ++ Multipe 0.99 + + localization sites RB5657 Conserved Hypothetical protein 4.96 14.6 G Multipe 1.00 + + localization sites RB7120 Conserved Hypothetical protein 6.01 37.9 F Multipe 0.98 + localization sites RB10078 Conserved Hypothetical protein 4.73 76.9 O Multipe 0.99 + + + localization sites RB2640 Hypothetical protein signal peptide 4.62 38.1 G Cytoplasmic 0.99 + + + + RB1656 Conserved Hypothetical protein 4.82 97.4 T Cytoplasmic 0.80 + + + + RB5786 Conserved Hypothetical protein 4.52 50.4 R Cytoplasmic 0.87 + + RB7627 Conserved Hypothetical protein 6.35 58.2 R Cytoplasmic 0.95 + + RB9164 Conserved Hypothetical protein 5.40 66.4 O Cytoplasmic 0.99 + + RB10948 Conserved Hypothetical protein 4.21 17.1 C Unknown 0.94 + + + + RB6430 Conserved Hypothetical protein 5.30 32.3 D Unknown 0.99 + + + + + RB9034 Conserved Hypothetical protein 5.37 113.7 D Unknown 0.91 + + RB3639 Conserved Hypothetical protein 8.92 30.7 E Unknown 0.99 + + RB8980 Conserved Hypothetical protein 4.82 67.8 E Unknown 0.92 + RB13143 Conserved Hypothetical protein 4.50 46.5 E Unknown 1.00 + + RB2971 Conserved Hypothetical protein 6.53 37.5 G Unknown 0.76 + + RB3919 Conserved Hypothetical protein 5.00 179.1 G Unknown 0.96 + + RB11978 Conserved Hypothetical protein 6.19 97.3 G Unknown 0.98 + + RB13146 Conserved Hypothetical protein 7.21 35.9 G Unknown 1.00 + + RB11010 Conserved Hypothetical protein 4.88 30.9 H Unknown 1.00 + + + + RB6888 Conserved Hypothetical protein 4.23 45.8 J Unknown 0.99 + + RB2822 Conserved Hypothetical protein 7.32 54.4 L Unknown 0.81 + + RB85 Conserved Hypothetical protein 5.06 45.7 M Unknown 1.00 + + + RB4182 Conserved Hypothetical protein 5.11 48.8 O Unknown 1.00 + + + RB6145 Conserved Hypothetical protein 7.27 35.7 P Unknown 0.97 + + + RB2908 Conserved Hypothetical protein 5.47 34.4 Q Unknown 1.00 + RB3070 Conserved Hypothetical protein 5.90 55.9 R Unknown 0.99 + + + RB9546 Conserved Hypothetical protein 5.04 30.3 R Unknown 0.99 + RB11698 Conserved Hypothetical protein 4.23 26.5 R Unknown 1.00 + + + + RB12056 Conserved Hypothetical protein 4.71 122.7 R Unknown 0.92 + RB107 Conserved Hypothetical protein 4.39 49.4 S Unknown 0.93 + + RB10195 Conserved Hypothetical protein 5.30 29.3 S Unknown 1.00 + + RB11998 Conserved Hypothetical protein 4.08 45.9 S Unknown 1.00 + + RB12301 Conserved Hypothetical protein 4.36 20.5 S Unknown 1.00 + + + RB9101 Conserved Hypothetical protein 6.96 20.3 S Unknown 1.00 + + RB4256 Conserved Hypothetical protein 4.65 37.1 U Unknown 1.00 + + RB5608 Putative large multi-functional protein 4.78 50.1 V Unknown 1.00 + + + + RB395 Conserved Hypothetical protein 5.90 93.4 ++ Unknown 1.00 + + RB426 Conserved Hypothetical protein 4.89 134.5 ++ Unknown 1.00 + + RB569 Conserved Hypothetical protein 6.63 29.8 ++ Unknown 0.87 + + + + + RB778 Conserved Hypothetical protein 7.28 44.4 ++ Unknown 0.83 + + RB1776 Conserved Hypothetical protein 7.74 41.4 ++ Unknown 0.97 + + RB2901 Conserved Hypothetical protein 4.77 42.8 ++ Unknown 1.00 + + RB3804 Conserved Hypothetical protein 5.09 141.4 ++ Unknown 0.99 + + RB5031 Conserved Hypothetical protein 6.79 29.7 ++ Unknown 0.99 + + RB5763 Conserved Hypothetical protein 4.22 45.2 ++ Unknown 0.99 + RB6221 Conserved Hypothetical protein 4.79 112.9 ++ Unknown 0.99 + + RB6409 Conserved Hypothetical protein 5.29 40.1 ++ Unknown 0.95 + RB9849 Conserved Hypothetical protein 8.69 31.5 ++ Unknown 1.00 + + + RB10300 Conserved Hypothetical protein 6.10 115.7 ++ Unknown 0.94 + + RB10581 Conserved Hypothetical protein 6.61 41.4 ++ Unknown 0.96 + + + + + RB11575 Conserved Hypothetical protein 7.61 38.3 ++ Unknown 1.00 + RB12084 Conserved Hypothetical protein 4.67 31.8 ++ Unknown 0.98 + + RB12489 Conserved Hypothetical protein 8.08 38.5 ++ Unknown 0.92 + RB12556 Conserved Hypothetical protein 6.90 44.6 ++ Unknown 1.00 + + + RB13222 Conserved Hypothetical protein 8.79 22.8 ++ Unknown 0.99 + + + RB6668 Conserved Hypothetical protein 4.72 76.1 S Extracellular + + + RB123 Conserved Hypothetical protein 11.24 48.8 N Cytoplasmic + + membrane RB1013 Conserved Hypothetical protein 4.90 154.6 S Cytoplasmic + + + membrane RB6291 Conserved Hypothetical protein 6.64 37.2 S Cytoplasmic + + + membrane RB10801 Conserved Hypothetical protein 4.94 91.4 S Cytoplasmic + + membrane RB6447 Conserved Hypothetical protein 4.81 84.5 ++ Cytoplasmic + + membrane RB12673 Conserved Hypothetical protein 4.29 55.2 C Cytoplasmic + + membrane RB12928 Conserved Hypothetical protein 6.06 41.7 V Cytoplasmic + + membrane RB13042 Probable membrane protein 7.88 45.2 R Cytoplasmic + + membrane RB9132 Conserved Hypothetical protein 5.78 46.5 R Periplasmic + + + + RB10524 Conserved Hypothetical protein 4.74 103.9 K Periplasmic + + + RB154 Lipoprotein receptor-related protein 3.66 261.8 U Multipe + + localization sites RB3077 Conserved Hypothetical protein 3.84 628.9 U Multipe + + + localization sites RB6969 Conserved Hypothetical protein 6.42 48.4 S Multipe + + localization sites RB6978 Conserved Hypothetical protein 5.72 79.4 M Multipe + + localization sites RB12697 Conserved Hypothetical protein 3.71 177.9 ++ Multipe + + + + localization sites RB12790 Conserved Hypothetical protein 4.44 261.5 ++ Multipe + + localization sites RB11991 Conserved Hypothetical protein 6.68 33.9 B Cytoplasmic + + RB7619 Conserved Hypothetical protein 5.90 30.6 C Cytoplasmic + RB5404 Conserved Hypothetical protein 8.07 41.5 D Cytoplasmic + + + RB12167 Conserved Hypothetical protein 5.07 28.8 G Cytoplasmic + + + RB3924 Conserved Hypothetical protein 4.38 35.0 G Cytoplasmic + + RB6095 Conserved Hypothetical protein 3.87 72.3 G Cytoplasmic + + RB6386 Conserved Hypothetical protein 5.95 42.0 G Cytoplasmic + + + RB8266 Conserved Hypothetical protein 6.36 37.9 G Cytoplasmic + + RB9932 Conserved Hypothetical protein 6.11 35.1 G Cytoplasmic + + RB9261 Conserved Hypothetical protein 5.03 45.9 H Cytoplasmic + + + RB12138 Conserved Hypothetical protein 6.33 48.2 J Cytoplasmic + + RB12060 Conserved Hypothetical protein 4.21 15.4 L Cytoplasmic + + + + RB2408 Conserved Hypothetical protein 9.61 31.2 L Cytoplasmic + + RB6669 Conserved Hypothetical protein 4.81 202.5 N Cytoplasmic + + + + RB5051 Conserved Hypothetical protein 6.41 42.1 O Cytoplasmic + + RB12035 Conserved Hypothetical protein 4.55 38.7 P Cytoplasmic + + RB2690 Conserved Hypothetical protein 7.01 56.8 P Cytoplasmic + + RB2498 Conserved Hypothetical protein 6.65 33.1 Q Cytoplasmic + RB3371 Conserved Hypothetical protein 5.23 51.0 Q Cytoplasmic + + RB3632 Conserved Hypothetical protein 4.85 26.4 Q Cytoplasmic + + RB404 Conserved Hypothetical protein 4.67 87.6 Q Cytoplasmic + + RB10957 Conserved Hypothetical protein 5.75 11.6 R Cytoplasmic + + + RB11174 Conserved Hypothetical protein 4.88 51.2 R Cytoplasmic + + RB11227 Conserved Hypothetical protein 5.55 51.5 R Cytoplasmic + + RB11516 Conserved Hypothetical protein 5.01 22.7 R Cytoplasmic + + RB4156 Conserved Hypothetical protein 5.41 31.3 R Cytoplasmic + + RB4278 Conserved Hypothetical protein 4.40 101.9 R Cytoplasmic + RB5042 Conserved Hypothetical protein 4.42 29.6 R Cytoplasmic + + RB6416 Conserved Hypothetical protein 4.96 49.9 R Cytoplasmic + + RB8202 Conserved Hypothetical protein 4.53 25.6 R Cytoplasmic + + + RB8284 Conserved Hypothetical protein 4.66 35.7 R Cytoplasmic + + RB8368 Conserved Hypothetical protein 4.67 36.7 R Cytoplasmic + + RB10026 Conserved Hypothetical protein 6.94 98.3 S Cytoplasmic + + + RB10028 Conserved Hypothetical protein 4.66 39.7 S Cytoplasmic + + RB10030 Conserved Hypothetical protein 4.89 59.6 S Cytoplasmic + + RB10494 Conserved Hypothetical protein 5.67 48.2 S Cytoplasmic + + RB12421 Conserved Hypothetical protein 5.28 55.7 S Cytoplasmic + + RB2121 Conserved Hypothetical protein 6.86 34.9 S Cytoplasmic + + RB2714 Conserved Hypothetical protein 9.37 33.1 S Cytoplasmic + RB3221 Conserved Hypothetical protein 4.97 43.8 S Cytoplasmic + + RB3476 Conserved Hypothetical protein 5.17 36.3 S Cytoplasmic + + RB5613 Conserved Hypothetical protein 9.75 42.1 S Cytoplasmic + + RB5749 Conserved Hypothetical protein 4.42 20.7 S Cytoplasmic + + RB7750 Conserved Hypothetical protein 4.80 66.4 S Cytoplasmic + + RB8684 Conserved Hypothetical protein 6.24 38.7 S Cytoplasmic + + + RB9218 Conserved Hypothetical protein 4.73 25.7 S Cytoplasmic + + RB9433 Conserved Hypothetical protein 4.71 25.1 S Cytoplasmic + + RB13180 Conserved Hypothetical protein 5.64 56.5 T Cytoplasmic + + RB4742 Conserved Hypothetical protein 4.73 35.5 T Cytoplasmic + RB4744 Conserved Hypothetical protein 6.05 34.0 T Cytoplasmic + + RB7190 Conserved Hypothetical protein 4.38 69.0 T Cytoplasmic + + + + RB10164 Conserved Hypothetical protein 8.07 21.5 ++ Cytoplasmic + + RB10430 Conserved Hypothetical protein 9.83 37.9 ++ Cytoplasmic + + RB13173 Conserved Hypothetical protein 11.78 14.9 ++ Cytoplasmic + + RB1533 Conserved Hypothetical protein 5.34 45.0 ++ Cytoplasmic + + RB4129 Conserved Hypothetical protein 4.62 46.5 ++ Cytoplasmic + + + RB520 Conserved Hypothetical protein 4.84 41.3 ++ Cytoplasmic + + RB538 Conserved Hypothetical protein 5.69 52.1 ++ Cytoplasmic + RB6458 Conserved Hypothetical protein 6.90 29.7 ++ Cytoplasmic + + RB666 Conserved Hypothetical protein 4.21 8.3 ++ Cytoplasmic + + RB8018 Conserved Hypothetical protein 4.91 96.9 ++ Cytoplasmic + + RB11343 Conserved Hypothetical protein 12.23 10.8 C Unknown + + RB9262 Conserved Hypothetical protein 5.18 54.0 C Unknown + + + RB8557 Conserved Hypothetical protein 6.01 58.1 D Unknown + RB951 Conserved Hypothetical protein 12.28 25.6 D Unknown + + RB10483 Conserved Hypothetical protein 5.90 14.5 E Unknown + + + + + + + RB4738 Conserved Hypothetical protein 5.35 36.5 F Unknown + RB12844 Conserved Hypothetical protein 6.08 37.8 G Unknown + + + RB3944 Conserved Hypothetical protein 6.35 57.4 I Unknown + + + RB4347 Conserved Hypothetical protein 4.73 17.5 K Unknown + + + + + RB11397 Conserved Hypothetical protein 8.77 23.1 L Unknown + + + RB7243 Conserved Hypothetical protein 6.63 21.2 L Unknown + + RB12608 Conserved Hypothetical protein 4.97 66.7 M Unknown + + + RB7603 Conserved Hypothetical protein 5.10 91.2 M Unknown + + + RB10789 Conserved Hypothetical protein 4.46 21.7 O Unknown + + + + RB10235 Conserved Hypothetical protein 5.04 20.4 Q Unknown + + RB10061 Conserved Hypothetical protein 4.34 40.2 R Unknown + RB11958 Conserved Hypothetical protein 4.48 32.9 R Unknown + + RB12882 Conserved Hypothetical protein 3.68 35.7 R Unknown + + + RB2642 Conserved Hypothetical protein 5.17 13.9 R Unknown + + + RB452 Conserved Hypothetical protein 4.86 114.3 R Unknown + RB457 Conserved Hypothetical protein 5.50 43.1 R Unknown + RB4714 Conserved Hypothetical protein 6.53 47.3 R Unknown + + RB6590 Conserved Hypothetical protein 4.90 89.6 R Unknown + + RB8783 Conserved Hypothetical protein 7.09 36.0 R Unknown + + RB11176 Conserved Hypothetical protein 4.76 17.2 S Unknown + + + RB1854 Conserved Hypothetical protein 9.45 75.8 S Unknown + + RB2976 Conserved Hypothetical protein 4.89 21.6 S Unknown + RB4230 Conserved Hypothetical protein 5.44 37.2 S Unknown + + RB4512 Conserved Hypothetical protein 4.80 45.7 S Unknown + + RB4613 Conserved Hypothetical protein 4.66 12.2 S Unknown + + + RB4629 Conserved Hypothetical protein 4.43 10.2 S Unknown + + RB6530 Conserved Hypothetical protein 5.46 25.8 S Unknown + + RB6586 Conserved Hypothetical protein 5.59 21.9 S Unknown + + + RB7538 Conserved Hypothetical protein 4.66 73.1 S Unknown + + + RB8163 Conserved Hypothetical protein 5.77 25.7 S Unknown + + RB9587 Conserved Hypothetical protein 7.53 73.8 S Unknown + + RB11828 Conserved Hypothetical protein 4.15 69.8 U Unknown + + RB11585 Conserved Hypothetical protein 5.17 25.1 ++ Unknown + + RB12144 Conserved Hypothetical protein 12.10 11.5 ++ Unknown + + + RB12215 Conserved Hypothetical protein 10.78 18.7 ++ Unknown + + RB12250 Conserved Hypothetical protein 11.9 12.4 ++ Unknown + + RB12266 Conserved Hypothetical protein 12.14 7.5 ++ Unknown + + RB12297 Conserved Hypothetical protein 4.41 17.9 ++ Unknown + + RB12451 Conserved Hypothetical protein 8.62 33.9 ++ Unknown + + + RB12649 Conserved Hypothetical protein 10.06 12.6 ++ Unknown + + RB12707 Conserved Hypothetical protein 8.28 49.8 ++ Unknown + + + RB12770 Conserved Hypothetical protein 11.94 18.5 ++ Unknown + + RB13115 Conserved Hypothetical protein 8.39 8.8 ++ Unknown + + RB13183 Conserved Hypothetical protein 11.61 9.0 ++ Unknown + + RB13312 Conserved Hypothetical protein 8.29 45.1 ++ Unknown + + + RB13319 Conserved Hypothetical protein 7.22 45.2 ++ Unknown + + RB13327 Conserved Hypothetical protein 7.25 45.1 ++ Unknown + + + RB2398 Conserved Hypothetical protein 4.81 31.4 ++ Unknown + + RB2501 Conserved Hypothetical protein 5.22 34.4 ++ Unknown + + RB2560 Conserved Hypothetical protein 11.46 10.9 ++ Unknown + + RB2782 Conserved Hypothetical protein 7.35 63.8 ++ Unknown + + RB3400 Conserved Hypothetical protein 6.51 44.5 ++ Unknown + + RB3542 Conserved Hypothetical protein 6.79 43.7 ++ Unknown + + + RB3982 Conserved Hypothetical protein 4.81 9.7 ++ Unknown + + RB3995 Conserved Hypothetical protein 11.92 10.3 ++ Unknown + + RB4489 Conserved Hypothetical protein 5.56 18.5 ++ Unknown + + RB6610 Conserved Hypothetical protein 5.47 137.8 ++ Unknown + + + RB7822 Conserved Hypothetical protein 4.80 19.2 ++ Unknown + RB8223 Conserved Hypothetical protein 5.23 74.4 ++ Unknown + + RB870 Conserved Hypothetical protein 5.40 45.9 ++ Unknown + + + RB8898 Conserved Hypothetical protein 4.60 35.1 ++ Unknown + + +

5 Hypothetical proteins RB1337 Hypothetical protein 4.74 50.1 ++ Extracellular 1.00 + + + RB3437 Hypothetical protein 4.46 48.6 ++ Outer 1.00 + membrane RB9527 Hypothetical protein 6.53 52.5 ++ Outer 0.99 + + + membrane RB12795 Hypothetical protein 4.49 87.6 ++ Outer 0.95 + + membrane RB9474 Hypothetical protein 5.49 87.3 ++ Cytoplasmic 0.99 + + membrane RB12676 Hypothetical protein 9.37 49.6 G Cytoplasmic 0.99 + + membrane RB1002 Hypothetical protein 5.25 77.5 E Multipe 0.86 + + localization sites RB1950 Hypothetical protein 4.57 73.1 ++ Multipe 0.99 + + localization sites RB6257 Hypothetical protein 4.63 22.5 C Multipe 0.89 + + localization sites RB10386 Hypothetical protein 4.49 31.1 D Multipe 0.99 + + localization sites RB12073 Hypothetical protein 5.94 32.8 G Multipe 1.00 + + + + localization sites RB12968 Hypothetical protein 4.65 74.6 ++ Multipe 1.00 + localization sites RB7447 Hypothetical protein 12.33 24.4 ++ Cytoplasmic 0.84 + + RB9010 Hypothetical protein 9.50 31.2 T Cytoplasmic 0.88 + + RB2 Hypothetical protein 3.70 6.5 ++ Unknown 0.98 + + RB5 Hypothetical protein 4.21 41.4 ++ Unknown 1.00 + + + RB512 Hypothetical protein 4.27 47.7 M Unknown 1.00 + + RB1252 Hypothetical protein 3.83 72.5 O Unknown 0.99 + + + + RB1260 Hypothetical protein 4.35 36.5 ++ Unknown 1.00 + + RB1467 Hypothetical protein 5.62 133.2 E Unknown 1.00 + + RB1523 Hypothetical protein 7.26 16.7 ++ Unknown 0.87 + + RB1979 Hypothetical protein 5.04 111.7 ++ Unknown 0.99 + + RB2003 Hypothetical protein 5.14 31.4 D Unknown 1.00 + + RB2096 Hypothetical protein 5.23 36.4 J Unknown 0.90 + + + RB2125 Hypothetical protein 4.77 25.7 ++ Unknown 1.00 + + RB2830 Hypothetical protein 4.51 46.4 I Unknown 1.00 + + + RB3462 Hypothetical protein 9.36 20.0 ++ Unknown 1.00 + + + RB3577 Hypothetical protein 6.12 20.0 E Unknown 0.99 + RB4127 Probable secreted protein 6.52 31.1 R Unknown 0.84 + RB4272 Hypothetical protein 7.69 49.3 O Unknown 0.93 + + RB4464 Hypothetical protein 5.11 25.7 D Unknown 0.99 + + RB4919 Hypothetical protein 7.04 19.0 P Unknown 1.00 + + RB5240 Hypothetical protein 5.03 19.5 ++ Unknown 1.00 + + RB5575 Hypothetical protein 9.48 34.2 R Unknown 1.00 + + RB5811 Hypothetical protein 4.94 32.0 S Unknown 1.00 + RB6127 Hypothetical protein 4.37 156.6 N Unknown 1.00 + + + RB6658 Hypothetical protein 5.71 38.0 ++ Unknown 1.00 + + RB6771 Hypothetical protein 6.19 40.6 ++ Unknown 0.98 + RB6789 Hypothetical protein 4.98 20.2 ++ Unknown 0.79 + + RB6941 Hypothetical protein 6.68 21.8 ++ Unknown 0.99 + + RB7235 Hypothetical protein 4.72 29.4 ++ Unknown 0.99 + + + + RB7267 Hypothetical protein 4.74 62.9 ++ Unknown 1.00 + + + RB7364 Hypothetical protein 5.01 45.3 G Unknown 0.99 + + RB7658 Hypothetical protein 7.52 22.1 R Unknown 1.00 + + + RB8228 Hypothetical protein 4.45 38.5 ++ Unknown 1.00 + + + + RB8559 Hypothetical protein 5.95 20.3 ++ Unknown 0.98 + + RB9020 Hypothetical protein 6.28 42.6 L Unknown 0.98 + + RB9037 Hypothetical protein 6.37 37.0 R Unknown 1.00 + + RB9512 Hypothetical protein 4.27 34.9 ++ Unknown 0.99 + RB9566 Hypothetical protein 11.07 4.1 ++ Unknown 0.86 + + RB9945 Hypothetical protein 5.22 35.6 ++ Unknown 1.00 + + + RB10077 Hypothetical protein 3.38 9.6 ++ Unknown 0.99 + + + RB10460 Hypothetical protein 4.42 51.7 ++ Unknown 0.99 + RB11107 Hypothetical protein 6.94 25.1 S Unknown 1.00 + + + + RB11952 Hypothetical protein 9.15 14.5 ++ Unknown 1.00 + + + RB12461 Hypothetical protein 4.29 61.3 N Unknown 0.99 + + + + RB12634 Hypothetical protein 6.63 17.5 ++ Unknown 0.98 + + RB12808 Hypothetical protein 4.58 41.0 ++ Unknown 1.00 + RB12965 Hypothetical protein 11.04 22.3 R Unknown 1.00 + + RB1722 Probable 60 kDa outer membrane protein 5.41 70.4 M Outer + + + (Precursor) membrane RB752 Hypothetical protein 4.90 109.9 ++ Outer + + membrane RB10835 Hypothetical protein 4.59 108.4 ++ Outer + membrane RB675 Hypothetical protein 6.74 50.5 F Cytoplasmic + + membrane RB2432 Hypothetical protein 9.84 30.5 G Cytoplasmic + + membrane RB3252 Hypothetical protein 6.27 36.6 R Cytoplasmic + + membrane RB6233 Hypothetical protein 11.60 6.4 R Cytoplasmic + + membrane RB7418 Hypothetical protein 4.68 387.8 N Multipe + + localization sites RB7093 Hypothetical protein 3.61 22.4 ++ Cytoplasmic + + membrane RB8992 Hypothetical protein 4.39 73.2 ++ Cytoplasmic + + membrane RB9327 Hypothetical protein 8.42 37.5 ++ Cytoplasmic + + membrane RB8846 Hypothetical protein 4.02 33.9 C Cytoplasmic + + RB5214 Hypothetical protein 6.12 57.1 D Cytoplasmic + + RB6107 Hypothetical protein 6.15 77.4 L Cytoplasmic + + RB34 Hypothetical protein 4.48 29.0 O Cytoplasmic + + RB5241 Hypothetical protein 4.24 24.6 O Cytoplasmic + + RB3689 Hypothetical protein 4.72 27.1 Q Cytoplasmic + + + + RB12428 Hypothetical protein 7.31 36.2 R Cytoplasmic + + RB3710 Hypothetical protein 5.49 60.0 R Cytoplasmic + + RB9350 Hypothetical protein 5.83 83.2 R Cytoplasmic + + RB9494 Hypothetical protein 4.83 31.0 R Cytoplasmic + + RB9860 Hypothetical protein 4.84 37.7 R Cytoplasmic + + + + RB6713 Hypothetical protein 4.59 34.5 T Cytoplasmic + RB8677 Hypothetical protein 5.81 33.2 T Cytoplasmic + + RB7439 Hypothetical protein 8.22 47.9 U Cytoplasmic + + RB272 Hypothetical protein 8.83 4.4 ++ Cytoplasmic + + RB363 Hypothetical protein 9.65 9.3 ++ Cytoplasmic + + RB481 Hypothetical protein 5.00 125.9 ++ Cytoplasmic + + RB733 Hypothetical protein 7.31 32.8 ++ Cytoplasmic + + RB1632 Hypothetical protein 7.30 24.7 ++ Cytoplasmic + + + RB2719 Hypothetical protein 9.89 9.4 ++ Cytoplasmic + + RB2955 Hypothetical protein 8.79 12.4 ++ Cytoplasmic + + RB3112 Hypothetical protein 8.09 36.3 ++ Cytoplasmic + + RB3633 Hypothetical protein 12.07 10.1 ++ Cytoplasmic + + RB3661 Hypothetical protein 6.08 33.5 ++ Cytoplasmic + + RB4255 Hypothetical protein 8.80 21.6 ++ Cytoplasmic + + RB5401 Hypothetical protein 4.42 44.0 ++ Cytoplasmic + + RB7065 Hypothetical protein 8.50 22.6 ++ Cytoplasmic + + RB7555 Hypothetical protein 11.54 20.8 ++ Cytoplasmic + + RB8137 Hypothetical protein 4.43 8.6 ++ Cytoplasmic + + RB8337 Hypothetical protein 4.84 77.4 ++ Cytoplasmic + + RB8672 Hypothetical protein 11.52 13.8 ++ Cytoplasmic + + RB10530 Hypothetical protein 5.74 19.3 ++ Cytoplasmic + RB10620 Hypothetical protein 10.25 5.7 ++ Cytoplasmic + + RB10710 Hypothetical protein 5.40 69.2 ++ Cytoplasmic + + RB10956 Hypothetical protein 4.79 13.0 ++ Cytoplasmic + + + RB2016 Hypothetical protein 10.04 58.5 D Unknown + + RB7045 Hypothetical protein 8.61 16.8 E Unknown + + RB1535 Hypothetical protein 5.19 49.4 G Unknown + + + + RB4041 Hypothetical protein 4.96 35.0 G Unknown + RB11262 Hypothetical protein 5.03 35.7 I Unknown + RB8140 Hypothetical protein 4.11 62.4 N Unknown + + RB10088 Hypothetical protein 8.13 41.8 S Unknown + + RB3630 Hypothetical protein 6.72 34.7 S Unknown + + RB71 Hypothetical protein 4.52 16.2 ++ Unknown + + RB439 Hypothetical protein 8.39 11.5 ++ Unknown + + RB484 Hypothetical protein 10.68 6.2 ++ Unknown + + RB812 Hypothetical protein 12.33 8.0 ++ Unknown + + RB839 Hypothetical protein 6.49 6.7 ++ Unknown + + RB913 Hypothetical protein 8.65 50.3 ++ Unknown + + RB1088 Hypothetical protein 5.16 39.0 ++ Unknown + + RB1132 Hypothetical protein 8.68 6.1 ++ Unknown + + RB1183 Hypothetical protein 8.72 18.2 ++ Unknown + + RB12787 Hypothetical protein 5.19 56.0 ++ Unknown + RB1449 Hypothetical protein 9.96 7.5 ++ Unknown + + + + RB1634 Hypothetical protein 3.70 40.7 ++ Unknown + + RB1766 Hypothetical protein 4.01 4.1 ++ Unknown + + RB1838 Hypothetical protein 6.38 4.1 ++ Unknown + + RB1937 Hypothetical protein 11.48 4.3 ++ Unknown + + RB1961 Hypothetical protein 11.89 13.4 ++ Unknown + + RB2019 Hypothetical protein 11.92 7.0 ++ Unknown + + RB2075 Hypothetical protein 6.37 32.7 ++ Unknown + + + RB2140 Hypothetical protein 11.94 5.5 ++ Unknown + + RB2176 Hypothetical protein 11.05 14.4 ++ Unknown + + RB2454 Hypothetical protein 10.22 24.8 ++ Unknown + + + RB2587 Hypothetical protein 11.31 5.4 ++ Unknown + + RB2867 Hypothetical protein 4.75 78.1 ++ Unknown + + + RB2922 Hypothetical protein 7.52 5.4 ++ Unknown + + RB3062 Hypothetical protein 9.14 11.1 ++ Unknown + + RB3151 Hypothetical protein 10.92 8.3 ++ Unknown + + RB3387 Hypothetical protein 10.60 8.7 ++ Unknown + + + RB3847 Hypothetical protein 11.21 4.6 ++ Unknown + + RB3858 Hypothetical protein 8.99 6.9 ++ Unknown + + RB3882 Hypothetical protein 12.39 5.9 ++ Unknown + + RB4393 Hypothetical protein 11.96 8.4 ++ Unknown + + RB4468 Hypothetical protein 4.56 16.4 ++ Unknown + + RB4480 Hypothetical protein 6.51 9.4 ++ Unknown + + + RB4529 Hypothetical protein 4.45 19.1 ++ Unknown + + RB4536 Hypothetical protein 11.86 8.1 ++ Unknown + + + RB4644 Hypothetical protein 11.96 12.4 ++ Unknown + + RB4691 Hypothetical protein 12.00 32.3 ++ Unknown + + RB4810 Hypothetical protein 10.79 13.1 ++ Unknown + + RB4832 Hypothetical protein 9.20 8.0 ++ Unknown + + RB5088 Hypothetical protein 6.34 6.1 ++ Unknown + + RB5096 Hypothetical protein 12.51 8.6 ++ Unknown + + RB5225 Hypothetical protein 12.22 9.7 ++ Unknown + + RB5353 Hypothetical protein 12.13 32.2 ++ Unknown + + RB5374 Hypothetical protein 10.36 22.9 ++ Unknown + + RB5511 Hypothetical protein 4.51 58.3 ++ Unknown + RB5551 Hypothetical protein 6.07 70.9 ++ Unknown + + RB5649 Hypothetical protein 7.48 23.2 ++ Unknown + + RB5745 Hypothetical protein 10.98 13.6 ++ Unknown + + + RB5781 Hypothetical protein 8.48 30.7 ++ Unknown + + + RB6137 Hypothetical protein 10.00 11.5 ++ Unknown + + RB6310 Hypothetical protein 10.07 9.4 ++ Unknown + + RB659 Hypothetical protein 10.54 7.4 ++ Unknown + + RB6778 Hypothetical protein 5.71 6.6 ++ Unknown + + RB6799 Hypothetical protein 6.71 43.7 ++ Unknown + + + RB6909 Hypothetical protein 10.75 9.7 ++ Unknown + + RB6991 Hypothetical protein 10.47 55.9 ++ Unknown + + RB7188 Hypothetical protein 11.40 7.6 ++ Unknown + + RB7203 Hypothetical protein 4.63 16.8 ++ Unknown + + RB7290 Hypothetical protein 9.59 4.2 ++ Unknown + + RB7471 Hypothetical protein 11.90 10.6 ++ Unknown + + RB7594 Hypothetical protein 9.17 11.8 ++ Unknown + + RB7638 Hypothetical protein 12.02 14.5 ++ Unknown + + RB7984 Hypothetical protein 8.06 3.8 ++ Unknown + + RB8067 Hypothetical protein 6.52 7.3 ++ Unknown + + RB8520 Hypothetical protein 8.56 4.5 ++ Unknown + + RB8876 Hypothetical protein 8.51 9.6 ++ Unknown + + RB8957 Hypothetical protein 4.77 26.8 ++ Unknown + + + RB9030 Hypothetical protein 3.95 91.5 ++ Unknown + + + + RB9160 Hypothetical protein 10.72 12.9 ++ Unknown + + RB9532 Hypothetical protein 10.25 12.0 ++ Unknown + + RB9620 Hypothetical protein 7.25 63.6 ++ Unknown + + RB9798 Hypothetical protein 4.97 41.5 ++ Unknown + + RB9878 Hypothetical protein 9.28 13.3 ++ Unknown + + RB9903 Hypothetical protein 9.27 28.9 ++ Unknown + + RB9904 Hypothetical protein 10.87 9.3 ++ Unknown + + RB10958 Hypothetical protein 5.38 18.1 ++ Unknown + + + RB11114 Hypothetical protein 12.22 6.9 ++ Unknown + +