An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_005222025Cyc: 121 Cellular Overview Connections between pathways are omitted for legibility. pro a dicarboxylate a dicarboxylate an amino putrescine putrescine thiosulfate a hexose 6- glycine betaine glycine succinate γ-butyrobetaine L-ascorbate acid a dipeptide a dipeptide a dipeptide poly-β-1,6- 1-(β-D O-acetyl-L-serine O-acetyl-L-serine spermidine spermidine D-mannitol galactitol sulfate phosphate phosphate phosphate betaine Fe 3+ an amino an amino D-cellobiose an aromatic an aromatic a dipeptide 6 phosphate phosphate N-acetyl-D- thiamine cys cys spermidine spermidine protoheme 2+ citrate N -(D-fructosyl)-L-lysine L-proline betaine glutamate L-proline betaine L-carnitine acid an amino acid an amino an amino an amino an amino a tripeptide a tripeptide a tripeptide amino acid amino acid ribofuranosyl) (R)- putrescine Fe N-acetyl-D- molybdate phosphate a hydroxamate 3+ 3+ arbutin shikimate enterobactin 2-oxoglutarate N 6 -(D-psicosyl)-L-lysine D-sorbitol D-glucosamine D-mannitol galactitol N-acetylneuraminate N-acetylneuraminate sulfate sulfate sulfate glycine betaine 4-aminobutanoate 4-aminobutanoate glycine betaine ammonium Fe Fe acid acid acid acid acid glucosamine a dipeptide diphosphate nicotinamide pantothenate spermidine enterobactin muramate sulfate predicted Fe 3+ salicin predicted predicted predicted predicted predicted predicted predicted ABC predicted predicted predicted predicted predicted ABC ABC PEP-driven PEP-driven ABC ABC ABC transporter ABC PEP-driven ABC ABC ABC RS23895 RS19745 RS10320 RS02890 RS13700 RS06425 RS18935 transporter transporter RS12765 RS12770 RS08265 RS20570 RS20575 RS06380 RS20470 RS02380 RS07185 RS05795 RS20165 transporter RS01050 transporter RS01730 RS24720 RS03055 RS04525 transporter RS26845 RS07205 RS07260 RS05915 RS26305 RS01665 RS00415 transporter transporter RS25430 RS06010 RS25690 of glycine transporter RS21215 RS24040 transporter RS23175 RS20580 RS21675 transporter RS01435 RS18675 RS19880 RS21035 RS12735 RS27505 transporter RS03765 RS12585 RS25575 RS01645 RS17670 RS05740 RS14010 RS23675 RS20010 transporter of spermidine/ of spermidine/ of D-mannitol of galactitol of sulfate/ of phosphate of phosphate betaine/ of glycine of L- of Fe3+ of an of a dipeptide putrescine putrescine thiosulfate L-proline betaine ascorbate amino acid poly-β-1,6- O-acetyl-L-serine O-acetyl-L-serine an aromatic an aromatic 1-(β-D (R)- putrescine spermidine spermidine protoheme Fe 2+ N-acetyl-D- D-sorbitol D-glucosamine D-mannitol galactitol 1- molybdate phosphate a hydroxamate N-acetyl-D- D-cellobiose 6'-phosphate thiamine shikimate enterobactin 2-oxoglutarate citrate N 6 -(D-fructosyl)-L-lysine N-acetylneuraminate N-acetylneuraminate sulfate sulfate sulfate L-proline betaine glutamate 4-aminobutanoate L-proline betaine ammonium L-carnitine Fe 3+ Fe 3+ an amino an amino an amino an amino an amino an amino an amino a tripeptide a tripeptide a tripeptide a dipeptide ribofuranosyl) cys cys muramate 6- 6-phosphate 6-phosphate 1-phosphate phosphate phosphate phosphate 3+ arbutin-6-phosphate amino acid amino acid diphosphate pantothenate spermidine enterobactin 6 sulfate a hexose 6- Fe glucosamine N -(D-psicosyl)-L-lysine D-mannitol galactitol 1- glycine betaine 4-aminobutanoate glycine betaine γ acid acid acid acid acid acid acid nicotinamide succinate phosphate -butyrobetaine L-ascorbate 3+ a dipeptide a dipeptide a dipeptide salicin 6-phosphate putrescine putrescine 1-phosphate phosphate thiosulfate phosphate phosphate phosphate glycine Fe an amino a dipeptide pro 6-phosphate a dicarboxylate a dicarboxylate spermidine spermidine sulfate betaine acid glycine betaine

Cofactor, Carrier, and Vitamin Biosynthesis Degradation/ NADH repair ATP Utilization/ an inactive 4-amino-4- α-Kdo-(2->4)- an O 6 - a DNA containing L-alanyl-γ-D- a mature iron(III)-[N-(2,3- iron(III)-[N-(2,3- an N ω -(1- GDP-α-D- a [protein]- peptidoglycan D- UDP-N-acetyl- a ribonucleoside phosphoenol an L-asparaginyl- an L-cysteinyl- an L-alanyl- superpathway of ubiquinol- Assimilation - Other a reduced adenosylcobinamide a purine α α methylguanine α dihydroxybenzoyl) a lipid II dihydroxybenzoyl)-L- Fermentation mixed acid fermentation biosynthesis superpathway of pyrimidine Nucleoside and Nucleotide Degradation ribonucleoside SAM deoxy- -L- -Kdo-(2->6)- L-cysteine an apurinic/ glutamyl-meso-2,6- peptidoglycan alanyl-DAP crosslink -D-muramoyl- Asn Cys hydroxy-2- mannose Pro a protein biotin biosynthesis I [2Fe-2S] iron-sulfur superpathway of superpathway of tetrahydrofolate biosynthesis and salvage superpathway of tetrahydrofolate biosynthesis flavin biosynthesis I ( and plants) superpathway of coenzyme A biosynthesis I (bacteria) superpathway of thiamine diphosphate biosynthesis I NAD de novo biosynthesis 5-hydroxybenzimidazolyl citrate activation Secondary Metabolite Biosynthesis uracil degradation III superpathway of pyrimidine flavodoxin (n) diphosphate dGDP pyruvate [tRNA ] [tRNA ] [tRNA ] ATP xanthine xanthine lys RS18805 lys 8 biosynthesis (prokaryotic) superpathway of menaquinol-8 biosynthesis I L-cysteine biosynthesis molybdenum biosynthesis deoxyribonucleosides degradation superpathway of purine deoxyribonucleosides degradation purine nucleotides degradation II (aerobic) UTP and CTP dephosphorylation I triphosphate ribonucleoside arabinopyranosyl lipid IV (E. coli) in DNA apyrimidinic site diaminopimeloyl- UDP-N-acetyl- (meso-DAP L-alanyl-γ-D- -L-serine] complex serine trimer] complex oxopropyl) biotin RS20880 I (from aspartate) 5-methylbenzimidazolyl Polyprenyl Biosynthesis NADH acetoacetate A class 1b HslU--HslV cluster biosynthesis demethylmenaquinol-8 biosynthesis I VI (from L-methionine) adenosylcobamide biosynthesis ribonucleosides degradation 5'-triphosphate α uracil uracil 3-methyl-2- a 5,10- adenosylcobamide biosynthesis degradation reductase ditrans,octacis D-alanine -D-muramate containing) glutamyl-meso-2,6- serine-type ribonucleoside- -[protein]- GDP-mannose peptidase from adenosylcobinamide-GDP 3'-dephospho-CoA methylerythritol phosphate pathway I phosphoenolpyruvate ADP 2'-deoxycytidine uracil UTP bifunctional murein IPP a malonyl-[acp] chorismate oxobutanoate methylenetetrahydrofolate cys from adenosylcobinamide-GDP autoinducer AI-2 biosynthesis I aerobactin myo-inositol polyisoprenoid biosynthesis (E. coli) cytidine (to acetyl CoA) -undecaprenyl bifunctional III: diaminopimeloyl- NADPH- D-Ala-D-Ala NADPH- diphosphate aminoacyl-tRNA aminoacyl-tRNA L-arginine mannosyl Cys- ATPase L-cysteine desulfurase chorismate GTP GTP GTP ATP asp flagellum- AMP bifunctional DD-endopeptidase/ malonyl-ACP O- met cys 5-hydroxybenzimidazole NaMN biosynthesis biosynthesis 2'-deoxyguanosine cytidine anaerobic phosphate DNA-binding C9E50_RS12590 UDP-N- lytic D-alanyl-D-alanine dependent carboxypeptidase dependent reductase: pyruvate : hydrolase: hydrolase: tRNA(Pro) bifunctional subunit: met RS25515 met isopentenyl- isochorismate methionine L-aspartate 5-methylbenzimidazole NaMN 2-(5''-triphosphoribosyl)- D-glyceraldehyde specific cytidine pyrimidine CTP synthase nucleoside acetoacetate adenosylcobinamide murein LD- uracil RS06870 uracil methyltransferase isochorismate 3-methyl-2-oxobutanoate cysteine pyruvate pyruvate kinase: pyk phosphoenolpyruvate deaminase: cdd ribonucleoside- transcriptional acetylmuramate:L- transglycosylase ferric chelate DacD: dacD ferric chelate nrdF nrdE kinase: pyk C9E50_RS15575 C9E50_RS15575 protein C9E50_RS09445 /Cys- biotin-- hslU diphosphate cysteine synthase GTP GTP adenosyltransferase: oxidase: nadB 3'-dephosphocoenzyme- 3-phosphate D-glucopyranose ATP deaminase: 2'-deoxyadenosine utilization uridine (glutamine triphosphatase acetoacetyl-CoA kinase/ bifunctional DNA- carboxypeptidase: BioC: bioC synthase GTP cyclohydrolase hydroxymethyltransferase: desulfurase cysteine molybdopterin- SAM IPP pyruvate kinase I: carboxylase: pyrimidine 5'- triphosphate lipid IV(A) 4- regulator/O6- alanyl-gamma-D- domain-containing reductase: reductase: deglycase tRNA(Cys) [acetyl-CoA- Delta-: desulfurase EntC: entC cyclohydrolase cyclohydrolase metK 2-iminosuccinate nicotinate-nucleotide-- A synthase: lys 6-phosphate (R)-NADHX synthase cdd thymidine protein hydrolyzing) NudI: nudI : adenosylcobinamide- formamidopyrimidine mepS serine-type [+ 2 isozymes] ribonucleoside- aminoacyl-tRNA aminoacyl-tRNA GDP-mannose a peptide a malonyl-[acp] methyl ester EntC: entC II: ribA panB CsdA: csdA desulfurase synthase GTP nicotinate-nucleotide-- C9E50_RS12370 C9E50_RS26630 : pyrimidine/purine methylguanine-DNA nfeF nfeF deacylase carboxylase] CsdA: csdA I FolE: folE I FolE: folE SAM dimethylbenzimidazole C9E50_RS20465 1-deoxy-D-xylulose- bifunctional FliI: fliI pyrimidine/purine A: rutA : pyrG C9E50_RS12275 reductase- phosphate amino-4-deoxy-L- glycosylase/ glutamyl- meso- protein: D-Ala-D-Ala diphosphate hydrolase: hydrolase: HchA: hchA mannosyl predicted C9E50_RS04750 isochorismate CsdA: csdA adenylyltransferase dimethylbenzimidazole isopentenyl- C9E50_RS24390 nucleoside methyltransferase murein DD- YbaK: ybaK /biotin Re/Si-specific [+ 2 isozymes] isochorismate 7,8- 7,8- 2,5-diamino-6-(5-phospho-D- asp [+ 2 isozymes] quinolinate phosphoribosyltransferase: 2'-(5''-triphospho-α-D- 5-phosphate ADP-dependent 2'-deoxyuridine pyrimidine/purine adenosine nucleoside UDP acetoacetyl-CoA activating guanylyltransferase: arabinosyltransferase: DNA-(apurinic diaminopimelate C9E50_RS05010 carboxypeptidase a N- reductase: pyruvate C9E50_RS22975 C9E50_RS22975 protein hydrolase: ABC beta-ketoacyl- synthase an [L-cysteine [+ 2 isozymes] MoeB: moeB GTP 3',8- phosphoribosyltransferase: diphosphate F0F1 ATP [+ 3 isozymes] purine ribonucleosides degradation Ada: ada endopeptidase operon + + synthase dihydroneopterin dihydroneopterin ribosylamino)pyrimidin-4(3H)-one synthase 6 nucleoside phosphorylase: protein: nrdG arnT ligase: mpl N-(2,3- N-(2,3- dGTP H NAD(P)(+) H DMAPP 2-dehydropantoate cobT ribosyl)-3'-dephospho-CoA synthase: SAH N -hydroxy- Ins(3)P pyruvate oxaloacetate NAD(P)H-hydrate deaminase: phosphorylase: 5 (Z)-3- CTP cobU or apyrimidinic [+ 4 isozymes] DacD: dacD D-ala acetylglucosamine- C9E50_RS08130 deglycase C9E50_RS09540 met transporter met ACP synthase an S-sulfanyl-[L- MenF: menF desulfurase]-S- an [L-cysteine a carboxy-adenylated cyclase cobT Delta-isomerase: synthase: GMP IMP FMN-N -oxide acetyl-CoA C- MepM: mepM Fe 2+ Fe 2+ repressor MenF: menF 3'-triphosphate 3'-triphosphate bifunctional aspartate 1- NadA: nadA C9E50_RS21370 L-lysine dehydratase/ phosphorylase: C9E50_RS12645 ppnP ureidoacrylate ppnP methylated-DNA-- site) lyase: mutM [+ 3 isozymes] dihydroxybenzoyl) dihydroxybenzoyl) nrdA YajL: yajL transhydrogenase of L- II: fabF cysteine desulfurase] sulfanyl-L-cysteine a ThiS sulfur- desulfurase]-S- [small subunit of MoaA: moaA citrate lyase holo- C9E50_RS04750 NAD-dependent atpI atpB adenosine nucleoside acyltransferase adenosyl- -N-acetylmuramyl- a 2'- BirA: birA (2E,6E)- isochorismate dihydroneopterin dihydroneopterin diaminohydroxyphosphoribosylaminopyrimidine 2-dehydropantoate decarboxylase: 5'-methylthioadenosine/ inositol-1- NAD(P)H-hydrate ppnP uridine an active 4'-α-L-Ara4N di-trans,octa-cis [protein]-cysteine S- UDP-N-acetylmuramoyl- -L-serine -L-serine trimer tRNA Asn a tRNA Cys ala a tRNA Pro methionine a 3-oxoglutaryl- isochorismate cysteine carrier protein sulfanyl-L-cysteine molybdopterin synthase] (8S)-3',8-cyclo-7,8- quinolinate 5-hydroxybenzimidazole ribotide phosphate [acyl-carrier protein] D-lactate malic : atpE atpF purine-nucleoside pyrimidine 5'- IMP triphosphatase FadA: fadA a flavodoxin cobinamide a mature GlcNAc-1,6- peptidoglycan peptidoglycan (tetrapeptide) deoxyribonucleoside asn cys panD S-adenosylhomocysteine formate C- adenosine UMP 5'-deoxyadenosine α methyltransferase: D-mannose + + farnesyl scaffold triphosphate triphosphate deaminase/5-amino-6-(5-phosphoribosylamino) 2-reductase: panE 5-methylbenzimidazole ribotide phosphate 1-deoxy-D-xylulose monophosphatase: DMAPP epimerase: thymidine pyrimidine/purine phosphorylase: peroxyureidoacrylate/ phosphorylase: met ribonucleoside a purine - -Kdo-(2-> -undecaprenyl L-alanyl-γ-D- peptidoglycan anhMurNAc- UDP-N- pyrophosphoryl- 5'-diphosphate H RS10830 H [acp] methyl ester SAH desulfurase ThiS dihydroguanosine synthase: citX dehydrogenase: ldhA C9E50_RS13980 atpH atpA adenosine nucleotidase: dehydrogenase: NudI: nudI semiquinone phosphate a 3'-terminal a 5'-phospho- (n) tetrapeptide, tetrapeptide, a [protein]- diphosphate protein for 2-succinyl-5- diphosphatase: diphosphatase: 5-phosphate nucleosidase: mtnN acetyltransferase: pflB C9E50_RS25380 nucleoside ureidoacrylate C9E50_RS27295 [+ 2 isozymes] triphosphate 4)-α-KDO-(2- phosphate C9E50_RS14490 γ (R)-lactate GDP formate RS18655 formate 2-succinyl-5- uracil reductase RibD: ribD β CsdA: csdA molybdopterin 5'-triphosphate carboxylating suhB atpG phosphorylase: 2'-deoxyinosine deoD C9E50_RS24390 guaB pyrimidine 5'- ribonucleoside unsaturated sugar [DNA] glutamyl-meso-2,6- (meso-DAP L-Ala- -D-Glu- glycan chain 1 glycan chain 2 D-ala acetylmuramoyl- undecaprenol L-arginine biotinyl-5'- synthase: ispA 3-oxo-glutaryl- iron-sulfur enolpyruvyl- nudB nudB (R)-pantoate -alanine adenylyltransferase: adenosylcobinamide-GDP a holo [citrate lyase (2E,6E)- [+ 2 isozymes] (S)-NADHX pyrimidine/purine phosphorylase: deaminase: amidohydrolase adenosine CDP reductase >6)-lipid IV 5-amino-6-(5-phospho- synthase nicotinate- 1-deoxy-D-xylulose- 6 6 (S)-malate deoA FMN nucleotidase: acetyl-CoA 5'-diphosphate A diaminopimeloyl- containing) DAP-D-Ala L-alanyl-γ-D- adenylate enolpyruvyl- 7,8- 7,8- 5'-methylthioadenosine/ [+ 2 isozymes] thiF cyclic pyranopterin ribazoletransferase: cobS adenosylcobinamide-GDP S-ribosyl-L-homocysteine N -acetyl-N - bifunctional atpD atpC nucleoside C9E50_RS12645 [+ 3 isozymes] uracil deaminase: geranyl [acp] methyl ester cluster 6-hydroxy-3- D-ribosylamino)uracil sulfurtransferase: nucleotide acyl-carrier protein] 5-phosphate farnesyl (R)-lactate ATP-dependent ppnP RutB: rutB C9E50_RS24390 a [protein]-S- D-alanine glutamyl-meso-2,6- 6-hydroxy-3- dihydroneopterin dihydroneopterin S-adenosylhomocysteine a [ThiI sulfur- a carboxy- monophosphate ribazoletransferase: cobS hydroxy-L-lysine glucose-1- ATP phosphorylase: thymine XMP C9E50_RS12645 a guanine in DNA F0F1 ATP reductase: fabG assembly: iscU cyclohexene- α α diphosphate fumarate hydratase pyrimidine/purine purine-nucleoside methyl-L-cysteine + + formate RS06895 formate diphosphate cyclohexene- 3'-phosphate 3'-phosphate bifunctional pantoate-- nucleosidase: mtnN D-glyceraldehyde carrier protein]-S- adenylated-[ThiS C9E50_RS11955 synthase diphosphorylase: Co -[ -(5-hydroxybenzimidazolyl)]- [citrate (pro-3S)- lipoate biosynthesis reductoisomerase: / formate acetyl-CoA NADH-hydrate ppnP inosine guanosine [+ 3 isozymes] diaminopimeloyl- H H an S-sulfanyl-[cysteine 1-carboxylic- β Coα-[α-(5-methylbenzimidazolyl)]- S-ribosylhomocysteine synthase: ispA FumD: fumD (Z)-3- synthase (2E,6E)- a (3R)-3-hydroxyglutaryl- 1-carboxylic- diaminohydroxyphosphoribosylaminopyrimidine beta-alanine 3-phosphate sulfanyl-L-cysteine sulfur-carrier protein] MoaC: moaC nadC Co -adenosylcobamide 5'-phosphate lyase] ligase: citC and incorporation II ispC inositol dehydratase: nucleoside phosphorylase: pyrimidine 5'- carbamate D-alanine desulfurase]-[disordered- acid synthase: S-ribosyl-L- AIR tyr a thiocarboxylated Coβ-adenosylcobamide 5'-phosphate lyase: luxS [+ 5 isozymes] uridine aminoacrylate xanthosine adenosine inosine guanosine CMP uridine farnesyl [acp] methyl ester acid synthase: deaminase/5-amino-6-(5-phosphoribosylamino) ligase: panC adenosylcobalamin/alpha- phosphatase: geranyl C9E50_RS25380 phosphorylase: deoD nucleotidase: 5,6-dihydrouracil form scaffold menD homocysteine 1-deoxy-D-xylulose- [small subunit of cyclic pyranopterin NaMN 1 formate citrate (Si)- phosphorylase: pyrimidine/purine pyrimidine/purine diphosphate 3-hydroxyglutaryl- menD uracil reductase RibD: ribD phosphomethylpyrimidine adenylate:persulfide ribazole phosphatase: adenosylcobalamin/alpha- an acetyl-holo [citrate octanoate MEP N -citryl-N C9E50_RS17780 diphosphate phosphate acetaldehyde ppnP C9E50_RS24390 pyrimidine 5'- a 2,3,4-saturated β protein] complex 5-phosphate 2-iminoacetate phosphate AI-2 6 6 fumarate C9E50_RS27295 nucleoside nucleoside core a peptidoglycan dimer N-acetyl-muramoyl-(L- a 1-acyl-2- poly- -1,6- a [protein]- (2R,3S)-3- queuosine at a [protein] a [protein]- a (1->4)- guanine RS00620 guanine acetate RS24190 acetate D-erythro-7,8- D-erythro-7,8- transferase: thiF molybdopterin synthase] ribazole phosphatase: lyase acyl-carrier protein] lipoate-- -acetyl-N - hydrogenlyase: hycC acetyltransferase: pta dehydrogenase synthase: gltA NADH nucleotidase: an L-1- a reduced trimethylamine + phosphoenol an L-cysteinyl- synthase: ispA [acp] methyl ester [cysteine desulfurase]-S- 2-succinyl-6- 2-succinyl-6- chorismate chorismate 5-amino-6-(5-phospho- S-ribosylhomocysteine synthase ThiC: thiC synthase: synthase nicotinate-nucleotide C9E50_RS20345 (2E,6E)- purine-nucleoside phosphorylase: phosphorylase: [+ 3 isozymes] a [formate C acetyltransferase]-glycine a reduced flavodoxin SAM oligosaccharide- with pentapeptide 1,2-diacyl-sn- alanyl-γ-D-glutamyl-L- coenzyme A VibB arachidonoyl- a [glutamine- FMN NADH H N-acetyl-D- FAD glu ala glu position 34 C-terminal glu α-D-glucan dihydroneopterin dihydroneopterin (R)-pantothenate 2-C-methyl-D- hydroxy-L-lysine myo-inositol hycD hycF hycG (acetylating): pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine C9E50_RS24390 phosphatidylethanolamine N-oxide ATP L-threonine GMP dADP pyruvate isopropylmalate [tRNA Pro ] L-histidine hydroxy-2, 4- lyase: luxS C9E50_RS20345 protein phosphate succinate phosphorylase: CTP TorY protein synthetase]- Asp 1,4-alpha- (2E,6E)-farnesyl dehydratase: fabZ sulfanylcysteine:[acceptor hydroxy-2, 4- D-ribitylamino)uracil C9E50_RS21370 ThiH: thiH molybdopterin adenylyltransferase: Coα-[α-(5-hydroxybenzimidazolyl) erythritol 4-phosphate farnesyl ppnP ppnP lipid A (E. coli stems (meso- glycerol 3-phosphate lysyl-D-alanyl-D-alanine) sn-glycerol glucosamine multifunctional of a tRNA L-glutamate sensor cyclohexadiene- bifunctional aminodeoxychorismate bifunctional aminodeoxychorismate HMP-P Coα-[α-(5-methylbenzimidazolyl) ligase acetyltransferase: C9E50_RS21710 dehydrogenase/ deoD CO 3-oxopropanoate nucleoside nucleoside nucleoside nucleoside [+ 3 isozymes] L-tyrosine glucan diphosphate a (2E)-enoylglutaryl- protein]-cysteine cyclohexadiene- 5-amino-6-(5- type I 1-deoxy-D-xylulose a thiocarboxy- synthase: nadD ]-Coβ-adenosylcobamide cytidylyltransferase: diphosphate citrate purine-nucleoside purine-nucleoside xanthosine 2 K-12 core type) diaminopimelate 3-phosphate CTP D-malate/3- histidine a metal a metal sulfurtransferase: 1-carboxylate dihydroneopterin synthase dihydroneopterin synthase pantothenate L-homocysteine [ThiS-Protein] 2-iminoacetate ]-Coβ-adenosylcobamide a [lipoyl-carrierLplA: lplA synthase: ispA CO H C9E50_RS07825 fumarate reductase 3-ureidopropanoate phosphorylase: phosphorylase: phosphorylase: phosphorylase: NAD(P)H-flavin FAD:protein kinase branching predicted chorismate 1-carboxylate 5-phosphate moaE moaD nicotinate adenine 2 2 2-deoxy-α-D- cytidine pyruvate formate lyase containing) phosphatidate holo-ACP isopropylmalate/ octaprenyl [acp] methyl ester phospho-D- superpathway of heme b bifunctional 6 ispD (2R,4S)-2-methyl-2,4- aconitate hydratase phosphorylase: phosphorylase: malonic ppnP ppnP ppnP ppnP serine-type Trimethylamine-N- poly-beta-1,6- FMN glutamate- tRNA 30S Cys- cation cation C9E50_RS06685 synthase: menH synthase: menH aldolase/7,8- component 1: pabB aldolase/7,8- component 1: pabB kinase: coaA protein] N - acetaldehyde iron-sulfur: frdA 1-activating protein: pflA synthase: reductase: nucleotide 5'- tartarate DpiB: dpiB enzyme: ABC RS25920 diphosphate a [cysteine desulfurase]- ribitylamino)uracil biosynthesis from glutamate hydroxymethylpyrimidine dinucleotide 4-(cytidine 5'- dihydroxydihydrofuran-3-one aerobactin (2E,6E)-farnesyl α ribose 1-phosphate deoD deoD semialdehyde phosphoethanolamine cytidylyltransferase: D-Ala-D-Ala oxide reductase 2: phosphatidate bifunctional [glutamate- N-acetyl-D- pyruvate -cysteine glutamyl- ribosomal tRNA(Pro) taurine taurine chorismate enoyl-ACP 2-succinyl-5- dihydroneopterin aminodeoxychorismate dihydroneopterin aminodeoxychorismate octanoyl-L-lysine AcnA: acnA C9E50_RS25445 uracil 2-deoxy- -D- purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside C9E50_RS06505 C9E50_RS27240 transferase monophosphate glgB transporter acetate acetate synthase: ispB S-sulfanyl-[disordered- 2-succinyl-5- D-ribulose 5-phosphate phosphatase: ybjI (R)-4'- kinase/ thiazole synthase: ammonia- ammonia- diphospho)-2-C- diphosphate acetyl phosphate pyrimidine/purine reductase: [formate-C- transferase: N-acetylmuramoyl- cdsA carboxypeptidase C9E50_RS11345 cytidylyltransferase: -ammonia ligase]- glucosamine kinase: pyk dehydrogenase: ligase: gshA Q(34) protein /Cys- two- a (1,6)-α-D- lyase: ubiC reductase enolpyruvoyl-6- epimerase: folB synthase epimerase: folB synthase molybdopterin lipoyl ethanolamine bifunctional frdC frdD ribose 1-phosphate thymine phosphopentomutase: phosphorylase: phosphorylase: phosphorylase: phosphorylase: NADPH- ApbE: apbE nucleosidase: ppnN of taurine all-trans- form scaffold enolpyruvoyl-6- 5-amino-6-(5- phosphopantothenate phosphomethylpyrimidine C9E50_RS26450 dependent dependent methyl-D-erythritol hypoxanthine guanine nucleoside C9E50_RS17750 acetyltransferase]- C9E50_RS17390 L-alanine amidase: phosphatidate DacD: dacD trimethylamine- holo-[acyl- cdsA adenylyl-L-tyrosine N-deacetylase dmlA glutamate-- synthetase S6--L- tRNA(Cys) component glucosyl-(1,4) FabI: fabI hydroxy-3-cyclohexene- 6-(hydroxymethyl) component 2: pabA 6-(hydroxymethyl) component 2: pabA glu synthase: utilization ethanol aconitate hydratase degradation deoB deoD deoD deoD deoD Polymeric Compound Degradation dependent FMN choline RS21930 choline octaprenyl hydroxy-3-cyclohexene- 3,4-dihydroxy- bifunctional molybdopterin NAD(+) NAD(+) 2-methyladeninyl heme a biosynthesis 4-(cytidine 5'- octaprenyl ethanolamine phosphopentomutase: phosphorylase: β pyrimidine deoxyribonucleotides activating enzyme: cytidylyltransferase: carrier-protein] phosphorylase/ PgaB: pgaB 3-isopropylmalate deacylase system α 4-hydroxybenzoate protein] complex 1-carboxylate phospho-D- kinase: thiD 2-[(2R,5Z)-2-carboxy- glutathione- lipA (2E,6E)-farnesyl- dehydrogenase 2/2-methylisocitrate succinate 2-deoxy-D-ribose -alanine [+ 4 isozymes] C9E50_RS05215 [+ 2 isozymes] N-oxide phosphatidate reductase: ssuE cysteine ligase: GluQRS: glutamate - -glucan nitrate RS15460 nitrate diphosphate a glutaryl-[acp] methyl ester cysteine 1-carboxylate -7,8-dihydropterin 4-amino-4- -7,8-dihydropterin 4-amino-4- 2-butanone- phosphopantothenoylcysteine L-cystathionine adenylyltransferase: synthetase: synthetase: adenosylcobamide biosynthesis a [lipoyl-carrier diphospho) (2R,4S)-2-methyl-2,3,3,4- diphosphate utilization acetate deoB thymine ppnP 3-hydroxypropanoate dephosphorylation C9E50_RS26650 C9E50_RS14365 synthase: acpS [glutamate-- a [protein]-FMN- D-ribose 5- dehydrogenase: YbaK: ybaK sensor 2-succinyl-6- ribitylamino)uracil 4-methylthiazol-5(2H)- glutaredoxin diphosphate- EutG: eutG dehydratase: acnB 5-phosphate α-D-ribose- glycogen degradation I [+ 3 isozymes] reductase cytidylyltransferase: pyruvate C9E50_RS20645 gluQRS ligase: rimK desulfurase 2-succinyl-6- 2-amino-4-hydroxy-6- deoxychorismate 2-amino-4-hydroxy-6- deoxychorismate 4-phosphate HMP-PP from adenosylcobinamide-GDP 6 -2-C-methyl- tetrahydroxytetrahydrofuran kinase EutP: eutP ammonia-ligase] AMP L-threonine hydroxy-2, 4- phosphatase decarboxylase/ redox reactions C9E50_RS24195 nadE nadE protoheme protein]-N -[(R) specific synthase: ispB Chemoautotrophic 2-deoxy-D-ribose xanthine guanine purine-nucleoside 1-phosphate nucleoside triphosphate chitin degradation II (Vibrio) lipid A-core- N-acetyl-muramoyl-(L- TorA: torA C9E50_RS14365 partially guanine phosphate dATP leuB histidine 4-hydroxybenzoate beta-ketoacyl- CsdA: csdA hydroxy-2, 4- hydroxymethyldihydropteridine hydroxymethyldihydropteridine synthase: ribB an L-glutamyl-[tRNA Glu ] phosphopantothenate-- cystathionine ylidene]ethyl phosphate D-erythritol [+ 3 isozymes] [+ 2 isozymes] a [formate C acetyltransferase]- a 1,2-diacyl- adenylyltransferase: acetate 4-methyl-2- kinase aminodeoxychorismate aminodeoxychorismate YigB: yigB molybdopterin 2-methyladenine protoheme IX -dihydrolipoyl]- salmochelin biosynthesis ditrans,polycis- cis-aconitate 5-phosphate dehydrogenase: deaminase: phosphorylase: pyrophosphatase γ γ + deacetylated poly- biotin RS27315 biotin cyclohexadiene- + Energy Metabolism deoxyribose- pseudouridine 5'-deoxyadenosine phosphoethanolamine sn-glycerol a peptidoglycan dimer L-alanyl- -D- a CDP-2,3,4-saturated- alanyl- -D-glutamyl- D-ala a holo-[VibB aryl- FMNH NAD γ glutamyl- a [protein] C- cyclohexadiene- diphosphokinase: folK diphosphokinase: folK gamma- glutathione NAD kinase: ispE all-trans- 5,6-dihydrothymine phosphopentomutase: a glycogen a flavodoxin semiquinone met 3',5'-ADP glnE 2 oxopentanoate -L-glutamyl- octaprenyltransferase: ACP synthase [+ 2 isozymes] lyase: pabC lyase: pabC 1-deoxy-L-glycero- cysteine ligase CoaBC: coaBC adenine dinucleotide nicotinate-nucleotide-- farnesyltransferase: L-lysine undecaprenyl- ethanol xdhC xdhB xdhA guaD deoD YhdE: yhdE glycin -2-yl radical β-1,6-N-acetyl- α a tRNA Pro PmrB: pmrB cyanate RS21770 cyanate an S-sulfanyl-[cysteine 1-carboxylate 1-carboxylate (7,8-dihydropterin- (7,8-dihydropterin- glutamyl-tRNA synthase: metB thiamine 2-phospho-4-(cytidine octaprenyl acetate aconitate hydratase phosphate degradation deoB chitin (hep I) with pentapeptide stem glutamyl-meso-2,6- diacylglycerol L-lysyl-D-alanine) carrier protein] a CDP-1-acyl- D-alanine queuosine at terminal -L- cys a [protein]- C9E50_RS26160 I: fabB tetrulose 4-phosphate ARP (R)-4'- dimethylbenzimidazole cyoE diphosphate hydrogen oxidation deoxyribose- adenosine an oxidized trimethylamine D-glucosamine α desulfurase]-S- synthase: menH synthase: menH 6-yl)methyl 6-yl)methyl reductase: phosphate molybdopterin 5'-diphospho)-2-C- enterobactin diphosphate AcnA: acnA aldolase: deoC nucleoside triphosphate glycogen (meso-diaminopimelate diaminopimeloyl- 2-arachidonoyl- position 34 glutamate- - N-phospho- beta-ketoacyl- (1R,6R)-6-hydroxy-2- 4-aminobenzoate 4-aminobenzoate phosphopantothenoyl- phosphoribosyltransferase: ferroheme o synthase: ispU I (aerobic) phosphate nucleotides D-ribose 5- TorY protein a [glutamine Asp sulfanyl-[disordered- (1R,6R)-6-hydroxy-2- cys synthase: thiE superpathway of pyridoxal 5'-phosphate biosynthesis and salvage molybdotransferase enterobactin C- xanthine pseudouridine pyrophosphohydrolase: phosphorylase: containing) D-alanyl-D-alanine glycerol of a tRNA L-glutamate L-histidine predicted 3-octaprenyl-4- ACP synthase succinylcyclohexa-2,4- diphosphate diphosphate hemA L-cysteine a reduced thiamine salvage II cobT methyl-D-erythritol preQ biosynthesis bifunctional aldolase: degradation III phosphate synthetase]-O form scaffold succinylcyclohexa-2,4- 6,7-dimethyl-8- MoeA: moeA 2-C-methyl-D- 0 glucosyltransferase: 3-(carbamoylamino)- pseudouridine mazG C9E50_RS02120 predicted ABC hydroxybenzoate II: fabF diene-1-carboxylate (S)-4-amino-5- bifunctional glutaredoxin di-trans,octa-cis aconitate hydratase H deoC acetaldehyde D-glyceraldehyde 3-phosphate dCTP dCMP 4 -(5'-adenylyl) thiamine thiamine protein] complex diene-1-carboxylate dihydropteroate dihydropteroate ribityllumazine D-erythrose MoO -molybdopterin 4-amino-2-methyl-5- erythritol 2,4- C9E50_RS17135 2 2-methylpropanoate S-methyl-5'-thioadenosine xanthine kinase: maltodextrin a chitodextrin ABC transporter UbiD family [cysteine desulfurase]-S- oxopentanoate phosphopantothenoylcysteine thiamine phosphate glutaredoxin 2 2-methyladenine ribotide phosphate monoglucosyl- -undecaprenyl 2/2-methylisocitrate Ni/Fe-hydrogenase AMP -L-tyrosine maltose maltose a 3-oxopimeloyl- o-succinylbenzoate synthase: folP synthase: folP synthase: ribE 4-phosphate cofactor pyrimidinemethanol cyclodiphosphate (S)-lactate fermentation to propanoate, acetate and hydrogen degradation IV dehydrogenase: C9E50_RS08435 phosphorylase: transporter of thiamine decarboxylase: sulfanylcysteine:[acceptor o-succinylbenzoate glutamate-1- decarboxylase/ 2: grxB enterobactin diphosphate dehydratase: acnB b-type cytochrome D-glyceraldehyde acetaldehyde nucleotide 5'- pseudouridine [acp] methyl ester synthase: menC adenosylcobalamin ferroheme i synthase: ispF GTP geranyl acetaldehyde dehydrogenase S-methyl-5'- xdhC xdhB xdhA dUTP diphosphatase: malP of maltose C9E50_RS05635 protein]-cysteine synthase: menC semialdehyde phosphopantothenate-- thiamine- erythrose-4- [+ 2 isozymes] bifunctional monoglucosyl- undecaprenyl- subunit: hyaC 3-phosphate monophosphate 5'-phosphate 7,8- 7,8- GTP diphosphate C9E50_RS00840 core 4-amino-4- a carboxy- a peptidoglycan a peptide with a [glutamine DNA with adenine:7,8- 2069 N-acetyl-α- a [protein]-L- N,N'- an S-(1-hydroxy- an [amino group Mo 2+ RS19675 Mo 2+ 3-oxo-pimeloyl- sulfurtransferase: salvage from cobalamin 6,7-dimethyl-8-(1-D-ribityl)lumazine cysteine ligase CoaBC: coaBC phosphate phosphate a protein with hydroxymethylpyrimidine adenosylcobinamide-GDP 2-C-methyl-D-erythritol- diphosphate (S)-lactate D-threo-isocitrate A(H2) (acetylating): thioadenosine urate nucleosidase: ppnN an L-1- a ring-opened 7- a guanine 4-hydroxy-3- 2-succinylbenzoate 2,1-aminomutase: benzimidazolyl adenosylcobamide enterobactin C- acetaldehyde (R)-3-amino-2- 5'-methylthioadenosine/ an α-limit dextrin 34 lipid IV (E. coli) MoO - 5 formate 2-succinylbenzoate dihydropteroate dihydropteroate cyclohydrolase biosynthesis pseudouridine- [+ 2 isozymes] a 5,10-gly a uridine oligosaccharide- deoxy-α-L- A glu a (6S)-5- adenylated- dimer (generic) an N-terminal synthetase]-O dihydro-8- 2 D-muramoyl- glutamate-O diacetylchitobiose 2-oxopropyl) carrier protein]- sulfite RS27060 sulfite [acp] methyl ester C9E50_RS06685 C9E50_RS23160 kinase: thiL dehydrogenase: reduced L- kinase/ ribazoletransferase: cobS 2,4-cyclodiphosphate 7,8- glucosyltransferase: phosphatase: C9E50_RS21710 S-adenosylhomocysteine [+ 3 isozymes] dUTP dUMP a chitodextrin phosphatidylethanolamine methylguanine in DNA cys in 23S rRNA ATP xanthosine ATP roseoflavin IMP polyprenylbenzoate a [cysteine biosynthesis from I FolE: folE NADP-dependent dehydrogenase methylpropanoate methylenetetrahydrofolate in tRNA formyltetrahydrofolate 4 -(5'-adenylyl) oxoguanine mismatch molybdopterin -methyl-ester γ reductase: fabG bifunctional bifunctional cob(I)alamin riboflavin 4'-phosphopantetheine C9E50_RS04550 cysteine residues phosphomethylpyrimidine ybjG IPP adenine 5'-phosphate lipid A (E. coli arabinopyranosyl [ThiS sulfur- Xaa-L-proline bifunctional L-alanine(1-) -[protein]- 5'-phosphate C-terminal- - decarboxylase: ubiD desulfurase]-(S- o-succinylbenzoate- superpathway of adenosylcobalamin salvage from cobinamide I Coα-[α-(2-methyladenin-9-yl)]-Co adenosylcobinamide-GDP flavodoxin- dihydroneopterin C9E50_RS17135 isocitrate (acetylating): acetyl-CoA nucleosidase: mtnN α cofactor o-succinylbenzoate- tetrahydrofolate tetrahydrofolate synthase: ribE 5-aminolevulinate thiamine diphosphate 4-phospho- pyridoxal 5'-phosphate salvage II (plants) kinase: thiD glycosidase: limit dextrin -1,6- K-12 core type) ditrans,octacis carrier protein] -L-tyrosine 23S rRNA chitin L-cysteine (L-glutamate 5- GMP a (3R)-3-hydroxypimeloyl- sulfanyl) -[disordered- -CoA ligase: menE β-adenosylcobamide 5'-phosphate dependent 3'-triphosphate undecaprenyl- (2E,6E)- dehydrogenase: C9E50_RS21710 MTR bifunctional DNA- lytic formate L-fucose RS05295 L-fucose 2 -CoA ligase: menE synthase/ synthase/ pantetheine- hydroxyferroheme i benzimidazole salmochelin S4 C9E50_RS08440 glucohydrolase: -undecaprenyl bifunctional A/G-specific (guanine(2069)-N(7) chemotaxis semialdehyde-2-N-acetyl- reductase: 2-octaprenylphenol [acp] methyl ester form scaffold a 5,10- D-erythronate (E)-4-hydroxy- 6-carboxytetrahydropterin diphosphate farnesyl 5-hydroxy-CTP 5-hydroxy-CMP tRNA uridine-5- formamidopyrimidine transglycosylase leucyl N-acetylmuramoyl- disaccharide dehydrogenase- ala RS24205 ala 4-(2'-carboxyphenyl) dihydrofolate dihydrofolate riboflavin porphobilinogen phosphate cob(II)inamide HMP-P adenosylcobalamin/alpha- nicotinate-nucleotide-- pyruvate C9E50_RS16020 glgX phosphoethanolamine phosphate tetrahydrofolate adenine )-methyltransferase molybdenum cofactor ribonucleoside response regulator bifunctional yl)-L-glutamategamma- guaC protein] complex 4-(2'-carboxyphenyl) methenyltetrahydrofolate cob(II)alamin 4-phosphoerythronate pyridoxal 3-methylbut- synthase QueD: queD phosphatase: diphosphate Respiration acetyl-CoA uracil carboxymethylaminomethyl(34) glycosylase/ cysteine domain-containing aminopeptidase: bifunctional [glutamate- L-alanine amidase: deacetylase: protein N: fdnI fdnG FAD-dependent 2- 3-hydroxypimeloyl- -4-oxobutyryl-CoA synthase: folC synthase: folC synthase: hemB adenylyltransferase: ribazole phosphatase: dimethylbenzimidazole diglucosyl- transferase: synthase/ glycosylase: RlmK/23S rRNA guanylyltransferase hydrolase protein-glutamate riboflavin glutamyl- -4-oxobutyryl-CoA bifunctional cob(I)yrinic acid a,c-diamide dehydrogenase 5-(2-hydroxyethyl) bifunctional 2-enyl- C9E50_RS03870 synthase: ispA 2-oxoglutarate beta-N- synthesis enzyme MnmG: mnmG DNA-(apurinic desulfurase: protein: pepA -ammonia ligase]- C9E50_RS05215 chbG deglycase octaprenylphenol [acp] methyl ester 1,4-dihydroxy- bifunctional ethanolamine coaD C9E50_RS20345 phosphoribosyltransferase: 6-carboxy-5,6,7,8- enterobactin C- geranyl a debranched C9E50_RS17390 dihydrofolate mutY (guanine(2445)-N(2) MobA: mobA RihC: rihC methylesterase: formate kinase/FAD phosphate GMP fluoride RS20410 fluoride 1,4-dihydroxy- 7,8-dihydrofolate 7,8-dihydrofolate riboflavin kinase/ adenosyltransferase: cobO PdxB: pdxB -4-methylthiazole hydroxymethylpyrimidine diphosphate di-trans,octa-cis pyruvate formate C- 2-oxoglutarate decarboxylation to succinyl-CoA maltotetraose α acetylhexosaminidase: tRNA uridine-5- lipid IV(A) 4- or apyrimidinic C9E50_RS12350 C9E50_RS05010 Xaa-Pro adenylyl-L-tyrosine [+ 3 isozymes] HchA: hchA an [amino group ornithine ornithine hydroxylase: ubiI dehydratase: fabZ 2-naphthoyl- methylenetetrahydrofolate utilization cob(I)yrinic porphobilinogen α α cobT tetrahydropterin glucosyltransferase: diphosphate -limit dextrin synthase: folC )-methyltransferase C9E50_RS11290 dehydrogenase- synthetase: reductase: 2-naphthoyl- monoglutamate monoglutamate FAD synthetase: ribF 3'-dephospho-CoA cob(I)yrinic acid a,c-diamide (3R)-3-hydroxy-2-oxo- pyridoxal pyridoxine/ kinase/ Co -[ -(2-methyladenin-7- ferroheme a synthase: ispG -undecaprenyl carboxylase: accC acetyltransferase: N,N'- nagZ N,N',N''- carboxymethylaminomethyl(34) [+ 5 isozymes] amino-4-deoxy-L- site) lyase: mutM [+ 2 isozymes] [+ 5 isozymes] aminopeptidase: phosphorylase/ N-acetyl-β-D- protein carrier protein]- lys RS07760 lys 3-(all-trans a (2E)-enoylpimeloyl- CoA dehydrogenase/ acid a,c-diamide hydroxyethylthiazole β benzimidazole ribotide phosphate C9E50_RS17135 RlmL: rlmKL adenylyl acetate N subunit ribF argC a [cysteine desulfurase]- CoA pyridoxal/ yl)]-Co -adenosylcobamide 7-carboxy-7- phosphate pflB a [2-oxoglutarate synthesis GTPase MnmE: mnmE arabinosyltransferase: pepP [glutamate-- an N 7 - N-acetyl-D- glucosaminyl- deglycase C-terminal-γ- arg arg -octaprenyl) synthase: methenyltetrahydrofolate adenosyltransferase hydroxymethylbilane adenosyltransferase: cobO 4 phosphooxybutanoate phosphatase: kinase: thiM phosphomethylpyrimidine (E)-4-hydroxy-3- triglucosyl- Inorganic Nutrient Metabolism glycogen glycogen diacetylchitobiose triacetylchitotriose an apurinic site molybdenum D-ribofuranose xanthine alpha: fdnG [acp] methyl ester [scaffold protein- synthase: FMN dephospho- pyridoxamine deazaguanine dehydrogenase arnT ammonia-ligase] 2069 muramate (1->4)-D- YajL: yajL Ca 2+ RS03165 Ca 2+ benzene-1,2-diol cyclohydrolase FolD: folD synthase: hemC 3-phosphoserine/ C9E50_RS19670 kinase: thiD methylbut-2-en- oxaloacetate [+ 2 isozymes] phosphorylase:phosphorylase: beta-N- lipid A-core- a 1,2-diacyl- 2,6-diamino-4- a (6S)-5- GlcNAc-1,6- adenine within DNA methylguanine ala a [protein]-α- (5-phospho- (2Fe-2S)] complex menB EutT: eutT CoA kinase: 4-methyl-5-(2- adenosylcobinamide-GDP synthase enterobactin pyruvate fermentation 6 an apurinic site a thiocarboxy- a lipid II cofactor MeOH roseoflavin enoyl-ACP menB [corrinoid adenosyltranferase]-cob(II)inamide kinase: pdxK E2 protein] N 34 pyrophosphoethanolamine adenylyltransferase: in 23S rRNA glucosamine L-glutamyl)- bifunctional 3- 10 phosphohydroxythreonine [+ 2 isozymes] pyridoxine 4- 1-yl diphosphate C9E50_RS02120C9E50_RS02120 acetylhexosaminidase: a 5-carboxymethylaminomethyluridine sn-glycerol hydroxy-5-(N-methyl) formyltetrahydrofolate ala anhydro-MurNAc- a peptide with L-glutamate 1,4-dihydroxy-2- an N - [+ 2 isozymes] bifunctional coaE D-glyceraldehyde phosphooxyethyl) HMP-PP ribazoletransferase: cobS QueE: queE NAD-dependent to ethanol II -lipoyl-L-lysine (aminomethyl)phosphonate degradation a 7,8-dihydrofolate within DNA AMP [ThiS-Protein] a proteinogenic glnE an electron- adenine arg RS04570 arg demethylubiquinone 3- reductase 1,4-dihydroxy-2- a 7,8-dihydrofolate a 7,8-dihydrofolate preuroporphyrinogen pyruvate transaminase: serC pyridoxal dehydrogenase: 4-hydroxy- glyphosate degradation III superpathway of sulfate assimilation methylphosphonate dimethyl sulfide selenate reduction two-component alkanesulfonate monooxygenase taurine nagZ in tRNA di-trans,octa-cis formamidopyrimidine pentapeptide an N-terminal CO L-glutamate naphthoyl-CoA formyltetrahydrofolate cob(II)alamin- riboflavin kinase/ 3-phosphate thiazole 2-oxoglutarate maltodextrin maltodextrin lipid II amino acid a [protein]- 2 transfer quinol dinucleotide FabI: fabI naphthoyl-CoA kinase Coα-[α-(benzimidazolyl)]-Coβ- 3-methylbut- 7-carboxy-7- malic enzyme: formate acetyl-CoA and cysteine biosynthesis degradation I degradation degradation IV A -undecaprenyl L-proline (R)-lactate O-methyltransferase/2- (2E,6E)-farnesyl [corrinoid FAD synthetase: ribF coenzyme A 4-phosphooxy- pdxI pyruvate phosphorylase:phosphorylase: N-acetyl-D- L-cysteine allantoin RS20890 allantoin a [co-chaperone]- 1,4-dihydroxy- (2E,6E)-farnesyl dihydrofolate uroporphyrinogen- PdxY: pdxY adenosylcobamide 5'-phosphate 2-enyl deazaguanine C9E50_RS13980 dehydrogenase 2-oxoglutarate (aminomethyl)phosphonate II (oxidation) phosphate a [glutamine- octaprenyl-6-hydroxy a pimeloyl-[acp] methyl ester diphosphate 1,4-dihydroxy- dihydrofolate phosphoribosylglycinamide adenosyltranferase] L-threonine thiamine formate phosphate ubiquinone- E1 component: dehydrogenase glyphosate selenate an alkylsulfonate FMNH malP malP glucosamine [scaffold protein- 2-naphthoyl- diphosphate reductase: folA FAD III synthase: hemD 1-deoxy-D-xylulose- diphosphate 7-cyano-7- aminoalkylphosphonate sulfate 3-phospho-D-glycerate methylphosphonate 2 taurine synthetase]- arg arg phenol methylase: 2-naphthoyl- reductase: folA formyltransferase: purN [corrinoid adenosyltranferase]-cob(I)inamide 4-hydroxythreonine- phosphate adenosylcobalamin/alpha- (S)-malate hydrogenlyase: acetyltransferase: pta dependent pyruvate phosphonate dimethyl sulfide sulfate ADP (2Fe-2S)] complex octaprenyl CoA octaprenyl 5-phosphate reductase: deazaguanine sucA E1 component: N-acetyltransferase: phnO phosphonate taurine L-tyrosine RS25665 C9E50_RS08145 CoA 4-phosphate PLP pyridoxine synthase: thiE ribazole phosphatase: 4-hydroxy- hycC hycD dehydrogenase: poxB C-P lyase sulfate D-3- adenylyltransferase: pimeloyl-ACP SSQ1 diphosphate hydrolase: diphosphate aminopropanol a tetrahydrofolate uroporphyrinogen-III synthase: pyridoxine ispH synthase fumarate phosphate dihydrolipoyl sucA (acetamidomethyl)phosphonate C-P lyase dioxygenase: chloride RS12810 chloride 2-methoxy- hydrolase: cob(I)yrinic acid a,c-diamide dehydrogenase: C9E50_RS20345 3-methylbut- hycF hycG acetaldehyde system protein adenylyltransferase: phosphoglycerate cysD cysN agmatine agmatine methyl ester chaperone: synthase: ispB menI synthase: ispB phosphate a tetrahydrofolate cob(I)alamin- C9E50_RS21370 QueC: queC hydratase acetyltransferase: dehydrogenase: system protein adenosine 5'- tauD 6-(all-trans- menI adenosyltransferase: cobO C9E50_RS23970 Coα-[α-(benzimidazolyl) 2-enyl a [2-oxoglutarate a [2-oxoglutarate PhnG: phnG cysD cysN dehydrogenase: predicted hscA all-trans-octaprenyl biosynthesis II [corrinoid uroporphyrinogen pyridoxamine thiamine phosphate IPP Metabolic Regulator Biosynthesis FumD: fumD C9E50_RS07825 lpdA phosphonate C- PhnG: phnG dimethyl sulfoxide phosphoselenate 2-aminoacetaldehyde octaprenyl)phenol 1,4-dihydroxy- all-trans-octaprenyl cob(I)yrinic acid a,c-diamide 3-amino-1- β diphosphate H ethanolamine utilization dehydrogenase dehydrogenase α-D-ribose-1-[[+N 3- isozymes] a mature peptidoglycan (meso 3-phenyl-2- a 7,8-dihydro-8- a ribonucleoside a guanine 2445 RNase II poly-A a protein a [peptide] an L-1- ABC BioH: bioH a [chaperone-ATP]- 1,4-dihydroxy- NAD biosynthesis from 2-amino- decarboxylase: hemE 1-deoxy-D- pyridoxine/ ]-Co -adenosylcobamide preQ 2 P lyase system C9E50_RS04620 a nucleoside 34 2-octaprenyl-6- diphosphate 2-naphthoate adenosyltranferase] 0 ethanol dehydrogenase 6 6 APS α-D-ribose-1-[+ 2 isozymes] a peptidoglycan F6P a [ThiI sulfur-carrier an unsulfurated 2',3'-cyclic H O a RNA-DNA hybrid triphosphate β a cytidine phosphatidyl- arg arg diphosphate 2-naphthoate thr adenosyltransferase: cobO xylulose 5- hydroxyacetone pyridoxine/ pyridoxamine reductase: [+ 5 isozymes] acetyl phosphate E2 protein] N E2 protein] N -S- (phosphonomethyl) muropeptide degradation -diaminopimelate containing) oxopropanoate tyr cys cys oxoguanine in DNA L-cystathionine in 23S rRNA 2 substrate mRNA RNA thr with incorrect (R)- -lysine EF-P lys with N-terminal transporter [co-chaperone]- 3-carboxymuconate semialdehyde cob(I)yrinic acid lipoate pyridoxal/ pyridoxine/ thiamine- folate transformations III (E. coli) protein PhnG: phnG NAD(P)H-flavin protein]-L-cysteine [sulfur carrier] GTP triphosphate Ile2 potassium- methoxyphenyl L-threonine 3- pyridoxal ispH ppGpp metabolism EutG: eutG -dihydrolipoyl- succinyldihydrolipoyl- 3-phosphooxypyruvate methylphosphonate- phosphate bifunctional disulfide bonds in tRNA β aspartate sn-glycerol + + a pimeloyl-[acp] [scaffold protein- coproporphyrinogen III phosphate 1-phosphate pyridoxamine pyridoxal/ 5'-phosphate isopentenyl- glycine] 5-triphosphate 2',3'-cyclic-nucleotide threonine thiol:disulfide lipid of L-arginine K transporting K hydroxylase: ubiH 1,4-dihydroxy- 2-amino-3- a,c-diamide salvage II adenosylcobinamide pyridoxal/ phosphate trehalose biosynthesis I mannosylglycerate glycine betaine fumarate [+ 2 isozymes] adenylyl-sulfate 5-triphosphate FMNH2-dependent reductase: α γ (2Fe-2S)] complex 1,4-dihydroxy- dehydrogenase: kinase: pdxK pyridoxamine oxidase: pdxH phosphatase: diphosphate ethanolamine [+ 2 isozymes] L-lysine L-lysine α-D-ribose 1- alpha-D-ribose 1- -D- L-alanyl- -D-glutamyl-meso- lytic transglycosylase N-acetylmuramoyl- 2'-: 23S rRNA ammonia-lyase, interchange kinase ATPase 2-methoxy-6-all 2-naphthoate carboxymuconate- adenosyltransferase: a [lipoyl-carrier pyridoxamine kinase: thiL biosynthesis I biosynthesis I (Gram- kinase: cysC 3-phosphoserine alpha-D-ribose 1- selenite alkanesulfonate C9E50_RS27240 maltotriose fructose-6- bifunctional DNA- inorganic 8-amino-7- 2-naphthoate C9E50_RS00945 coproporphyrinogen bifunctional pyridoxine 5'- kinase: pdxK C9E50_RS19670 a tetrahydrofolate Delta-isomerase: succinate utilization (acetamidomethylphosphonate) methylphosphonate dimethyl sulfone glucopyranose 2,6-diaminopimeloyl-D-alanine domain-containing L-alanine amidase: aspartate/ cysteine cysteine cpdB bifunctional (guanine(2069)-N(7) II: DNA- biosynthetic: ilvA protein elongation tRNA beta- YegS: nitrite RS02395 nitrite trans-octaprenyl- 6-semialdehyde cobO protein]-N 6 -[(R pyridoxal pyridoxamine kinase: pdxK pppGpp D-glucopyranose negative bacteria) ethanol aminotransferase: methylphosphonate monooxygenase: NADPH- cyanate degradation phosphate formamidopyrimidine GTPase HI: rnhA oxononanoate SSQ1 polyprenyltransferase: polyprenyltransferase: L-threonine III oxidase: hemF pyridoxal phosphate thiamine diphosphate C9E50_RS04750 GTP pyrophosphokinase: UDP-α-D-glucose GDP-α-D- acetate kinase 5-triphosphate 1-phosphate maltodextrin tyrosine/aromatic desulfurase: )-methyltransferase C9E50_RS14770 triphosphatase: directed RNA DsbG: dsbG factor P--(R) lysidine(34) aspartyl- yegS 1,4-benzoquinol cob(I)yrinic acid )-lipoyl]-L-lysine adenosylcobinamide kinase pyridoxal 5'-phosphate pyridoxal 6-phosphate dehydrogenase/ 5-triphosphate PAPS serC 5-triphosphate ssuD dependent FMN muramoyltetrapeptide protein: C9E50_RS05215 aldolase: fsa desulfurase: glycosylase/ fused tRNA maltose regulon Era: era ribonuclease bifunctional 1-(3-sn- lipid A RS18605 lipid A synthase: bioF chaperone menA menA dehydrogenase: synthase: C9E50_RS05385 mannose choline EutP: eutP diphosphatase: phnM glucosidase: aminotransferase: C9E50_RS12350 RlmK/23S rRNA C9E50_RS03885 polymerase: -beta-lysine synthetase peptidase: bifunctional kinase/adenosylcobinamide- PdxY: kinase kinase methionine guanosine-5'- fumarate reductase alpha-D-ribose 1- α carboxypeptidase: ldcA C9E50_RS05010 [+ 3 isozymes] C9E50_RS12350 DNA-(apurinic nucleotidyltransferase/ transcriptional [+ 5 isozymes] threonine bifunctional phosphatidyl) yiaY quinolinate a,c-diamide protoporphyrinogen IX pdxJ pyridoxamineoxidase: pdxH choline 2-oxoglutarate -D-ribose-1-[N- diphosphatase: phnM reductase: ssuE CO carbonic anhydrase: malZ C9E50_RS18535 fructose-6- (guanine(2445)-N(2) HII: rnhB rpoC rpoB ligase: epmA TilS: tilS iadA demethylmenaquinone ATPase: hscA phosphate pdxY PdxY: bifunctional GTP triphosphate,3'-diphosphate iron-sulfur: frdA [+ 3 isozymes] methylphosphonate phosphoadenosine O-phospho-L-serine α-D-ribose-1- 2 γ [+ 6 isozymes] [+ 2 isozymes] [+ 2 isozymes] or apyrimidinic 2',3'-cyclic repressor/ RNase II protein-disulfide -sn-glycerol nitrite nitrite 8-amino-7-oxononanoate L-2-amino-3- adenosyltransferase: (R)-lipoate pyridoxine/ 5'-phosphate PdxY: pdxY synthase: metH DMAPP alpha,alpha- α dehydrogenase: Hydrogen dehydrogenase (phosphonomethyl) L-alanyl- -D-glutamyl- phosphate )-methyltransferase ammonia-lyase/L- methyltransferase/2- demethylmenaquinol-8 carboxylating guanylyltransferase: cobU pdxY diphosphokinase/ diphosphatase: gppA 2-O-( -D- C9E50_RS25445 5-triphosphate phosphosulfate methylphosphonate selenodiglutathione C9E50_RS21780 alpha-glucosidase: ditrans,octacis- aromatic amino site) lyase: mutM phosphodiesterase/ cystathionine substrate with [+ 2 isozymes] isomerase/ 3-phosphate RS14035 demethylmenaquinol-8 oxobutanoate cobO protoporphyrinogen pyridoxal/ pyridoxine 5'-phosphate trehalose- betA acetate E1 component: glycine] 5-phosphate methanesulfinate alpha-D-glucose meso-diaminopimelate a peptidoglycan aldolase: fsa H + AMP phosphate diphosphate serine ammonia- a [chaperone- guanosine-3',5'-bis mannosyl)- Production reductase: cysH carbonate dehydratase: C9E50_RS03755 acid transaminase: 2 RlmL: rlmKL phosphate a purine RS04765 a purine methoxy-6-polyprenyl- adenosylmethionine- an [2Fe-2S] nicotinate- adenosylcob(III) guanosine 3'-diphosphate phosphate frdC frdD diphosphatase: phnM phosphoserine 5-phosphate a mature peptidoglycan a mature peptidoglycan strand undecaprenyldiphospho- a [ThiI sulfur- 2' nucleotidase/ beta-lyase an N - GDP DNA a nucleoside 5'- no poly-A tail lyase TdcB: tdcB protein chain a lysidine 34 ADP]-[disordered- bifunctional lipoate-- oxidase: hemG pyridoxamine pyridoxine pyridoxamine dihydrofolate 3-phospho- betaine aldehyde sucA α-D-ribose-1-(2-N- alpha-D-ribose 1- phosphate-specific murein tripeptide pentapeptide C9E50_RS25990 a sulfurated nitrate nitrate 1,4-benzoquinol -8-amino-7- nucleotide adenosyl-cobinamide phosphate pyridoxine/ pyrophosphate 3'- 5'-triphosphate 3'- pyruvate fermentation to acetoin III phosphoadenosine phosphatase: alpha-D-ribose 1- C9E50_RS23605 γ N-acetyl-(N- ala carrier protein]-S- ala phosphatase Cca: cca MalY: malY methylguanine 2445 monophosphate DsbC: dsbC elongation factor Ile2 asp a peptide cluster protein alamin-[corrinoid protein kinase: pdxK 5'-phosphate 5'-phosphate reductase: folA synthase: otsA hydrogen methylphosphonate phosphoglucomutase: maltose amidase MpaA: mpaA with (L-alanyl- -D-glutamyl- (non-reducing terminus) 2-oxobutanoate a protein in tRNA Fe 2+ RS02230 Fe 2+ form scaffold demethylmenaquinone 5,6-dimethylbenzimidazole serine pyrophosphohydrolase: spoT diphosphatase: spoT D-glycerate betaine-aldehyde succinate acetamidomethylphosphonate) C9E50_RS24315 methylphosphonate D-glyceraldehyde [sulfur carrier] 7,8-dihydro- an apurinic site a ribonucleoside RNA EF-P, β-lysyl-Lys34 methylase UbiE: ubiE oxononanoate diphosphorylase: adenosyltranferase] ligase protoporphyrin IX pyridoxal/ propanoyl-CoA production V 5-phosphate C-P- phosphosulfate C9E50_RS20110 meso-2,6-diaminopimeloyl- acetylglucosaminyl)muramate 3-(4- dihydroxyacetone sulfanyl-L-cysteine cystathionine in 23S rRNA with correct protein] complex methyltransferase/2- bifunctional pyridoxal a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate α α mannosyl-3- 5-phosphate 5-phosphate C-P- 3-phosphate 8-oxoguanine within DNA 3'-phosphate 6-methoxy-3- transaminase: bioA nadC cob(I)yrinic acid LplA: lplA pyridoxamine pyridoxal lipoate biosynthesis , -trehalose dehydrogenase: pyruvate lyase PhnJ: phnJ reductase: carbamate hydrogencarbonate 4-alpha- L-alanyl-D-glutamate D-alanine) tetrapeptide beta-lyase: metC disulfide bonds Ptd Gro RS08320 Ptd Gro non- methoxy-6-polyprenyl- aminoacetone deferrochelatase/ adenosylcobinamide nicotinate-nucleotide-- kinase pyridoxamine pyridoxamine C9E50_RS06570 glycine cleavage system phosphoglycerate alpha-D-ribose 1- ser lyase PhnJ: phnJ glutathioselenol an aldehyde FMN hydroxyphenyl) phe 2 2 methyl-2-all- a,c-diamide kinase: pdxK phosphatase: and incorporation 6-phosphate betB formate C9E50_RS20515 methanesulfonate glucanotransferase: 7,8-diaminopelargonate chaperonin 1,4-benzoquinol heme b biosynthesis II NAD salvage pathway II (PNC IV cycle) kinase/adenosylcobinamide- dimethylbenzimidazole PdxY: 5'-phosphate 5'-phosphate aminomethyltransferase phosphatase- methylphosphonate 5-phospho-α-D-ribose 5-phospho-α- pyruvate trans-octaprenyl- NaMN adenosyltransferase: (lipoyl)adenylate peroxidase pyridoxal C9E50_RS19670 thymidylate III (Bacillus) cyanase: cynS malQ L-Ala-D/L-Glu a sugar RS06600 a sugar molecular methylase UbiE: ubiE (oxygen-independent) D-aminopropanol phosphate phosphoribosyltransferase: pdxY oxidase: pdxH oxidase: pdxH GcvT: gcvT a (6S)-5-formyltetrahydrofolate trehalose- related protein: glycine betaine ubiquinone- 5-phosphate C-P- 1,2-cyclic phosphate sulfite serine D-ribose 1,2- 1,4-benzoquinol cobO EfeB: efeB kinase synthase: thyA bifunctional FMNH2-dependent epimerase: pyruvate ATP-dependent chaperone dehydrogenase: nicotinate-nucleotide + cobT [+ 2 isozymes] phosphatase: C9E50_RS10760 lyase PhnJ: phnJ D-glucopyranose L-homocysteine preQ preQ 2-octaprenyl- lipoate-- 5-methoxybenzimidazolyl ferrochelatase: NAD guanylyltransferase: cobU methylenetetrahydrofolate5-formyltetrahydrofolate an octanoyl-[acp] GTP ppGpp dependent pyruvate 5-phospho-α-D-ribosyl acetyltransferase: cyclic phosphate alkanesulfonate C9E50_RS14550 0 RS01890 0 dethiobiotin menaquinol-8 uroporphyrinogen-III gldA adenylyltransferase: PdxY: pdxY otsB 2-O-(α-D- ubiquinone- a reduced NADPH-dependent α preQ preQ ATPase: hscA cob(I)yrinic acid protein adenosylcobamide biosynthesis dehydrogenase/ lipoyl(octanoyl) dehydrogenase: poxB 5-phospho-α-D-ribose 1,2-cyclic phosphate C9E50_RS11060 5-phospho- -D-ribosyl monooxygenase: 1 1 3-methyl-6- C9E50_RS21095 α-ribazole 5'-phosphate PLP cyclo-ligase: mannosyl)- (S)-methylmalonyl-CoA succinyl-CoA dependent pyruvate hydrogenase CO synthetase an [Fe-S cluster uroporphyrinogen (R)-1- nadD a,c-diamide ligase adenosylcobinamide-GDP methylenetetrahydrofolate assimilatory 1,2-cyclic phosphate hydrogen selenide 2 L-alanyl-L-glutamate a sugar RS21860 a sugar methoxy-1,4- from adenosylcobinamide-GDP methenyltetrahydrofolateC9E50_RS04635 transferase α,α-trehalose ubiquinone- 1,2-cyclic phosphate phosphodiesterase: serine O- ssuD nitrate cyanate glucokinase: BioD: bioD biosynthesis decarboxylase: hemE aminopropan-2-ol nicotinate adenine adenosyltransferase: LplA: lplA protoheme reductase: metF a [glycine-cleavage D-glycerate dehydrogenase: poxB sulfite reductase phosphodiesterase: UDP-N-acetyl- guanosine benzoquinol glutathione NAD salvage pathway I (PNC VI cycle) pyridoxamine folate transformations I cyclohydrolase FolD: folD LipB: lipB GTP pyrophosphokinase: dependent pyruvate 5-phospho-α-D-ribosyl phnP acetyltransferase: C9E50_RS07380 a nascent peptidoglycan an N-terminal core M-antigen α-D-glucose α N-acetyl-D- a holo-[EntF methyl β-D-glucoside a CDP- (S)-1-pyrroline- a peptidyl- chaperone]-ATP adeninyl adenosylcobamide coproporphyrinogen III cobO 5-methoxybenzimidazole acetaldehyde flavoprotein: sulfite reduction IV an L-phenylalanyl- GDP- -D-glucose α a ribonucleoside O-succinyl-L- β-aspartyl dipeptide carbonic acid H O MeOH selenite serine serine ATP-dependent dinucleotide a [glycine- tetrahydromonapterin biosynthesis a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate complex H protein] nucleoside-diphosphate C9E50_RS05385 methylmalonyl- phnP (meso-DAP containing) oligosaccharide- (variant) monomer 6-phosphate glucosamine -D-glucosamine 2',3'-cyclic L-seryl-carrier ser formate dipeptidase 2 2 hydroxylase: nicotinate-nucleotide-- adenosylcobinamide-GDP dehydrogenase: poxB 1,2-cyclic phosphate α-D-ribose 1,5- cysE (dissimilatory) cytosol nonspecific L-lysyl-[protein] [tRNA Phe ] dGTP IMP triphosphate homoserine 6-phosphate diacylglycerol 5-carboxylate ATP dethiobiotin biosynthesis from 5-methoxy-6-methylbenzimidazolyl cleavage complex biosynthesis a 5,10- N 6 -octanoyl-L-lysine kinase: C9E50_RS06765 cysJ cysI α Fatty Acid and Lipid Degradation undecaprenyl monophosphate trifunctional Dcp substrate catalase/ putative RS05065 ubiF ammonia- ribazoletransferase: cobS + bifunctional GTP CoA mutase: scpA phosphodiesterase: phnP -D-ribose 1,5- urea cycle lipid A (E. coli protein] RNA a sugar RS14620 a sugar oxygen-independent adenosylcobamide biosynthesis adenosylcobalamin 6 dimethylbenzimidazole NAD bisphosphate dipeptidase: pepD fused tRNA synthetase NAD salvage adenosylcobinamide-GDP dependent H protein] N -[(R ammonia- NAD(+) methylenetetrahydrofolate bifunctional a reduced O-acetyl-L-serine bisphosphate nitrate K-12 core type) diphosphate transcriptional peroxidase selenate thr thr coproporphyrinogen (R)-1-amino- from adenosylcobinamide-GDP phosphoribosyltransferase: cys glu diphosphokinase/ hydrogen sulfide lytic transglycosylase alpha,alpha- poly-beta-1,6 nucleotidyltransferase/ CDP-diacylglycerol beta-aspartyl- Ni/Fe- serine serine 3-demethylubiquinol-8 BioD: bioD pathway IV (from NAD(+) )-lipoyl]-L-lysine dependent diphosphatase: methylenetetrahydrofolate Tetrapyrrole Biosynthesis acetoin hydrogenase 3 α-D-ribose 1,5-bisphosphate ribose 1,5- nitrate leucyl/phenylalanyl- (no GlcNAc) anaerobic 6-phospho-beta- regulator/proline carbonic HPI: katG reductase III oxidase: hemN 2-propanol O 5-methoxy-6- cobT GTP methylenetetrahydrofolate guanosine-3',5'-bis (R)-methylmalonyl-CoA oleate β-oxidation β domain-containing N-acetyl-D- 2',3'-cyclic enterobactin cystathionine diphosphatase: peptidyl- nicotinamide riboside) adenine NAD(+) nudC adenosylcobalamin 5'-phosphate dehydrogenase/ guanosine-3',5'- bisphosphokinase: reductase fatty acid -oxidation I (generic) tRNA--protein trehalose- nucleotide 5'- glucosidase: peptidase: dehydrogenase/L- polynucleotide anhydrase: hydrogenase subunit RS05320 NAD salvage 1-(β-D -2-phosphate methylbenzimidazole synthetase: 5-methoxybenzimidazole NAD(+) reductase: metF a [lipoyl-carrier protein] pyrophosphate 3'- formate arg D-glucopyranose glu ala protein: glucosamine dGTPase: phosphodiesterase/ biosynthesis ribonucleoside- gamma- C9E50_RS26840 dipeptidase catalase/ 3-demethylubiquinone- dethiobiotin nicotinate-nucleotide-- nicotinate-nucleotide-- synthetase: GTP methenyltetrahydrofolate bis(diphosphate) 3'- phnN cysteine phosphate cytochrome transferase: phosphate monophosphate C9E50_RS05735 iadA glutamate gamma- adenylyltransferase C9E50_RS21780 large YgfK: ygfK a sugar RS05085 a sugar pathway III (to protoporphyrinogen IX nadE ribotide phosphate glutamate- diphosphatase: 6 siroheme biosynthesis pyrophosphohydrolase: spoT ribose 1,5- 6-phosphate O-antigen synthase: triphosphate synthase: metB Dcp: dcp peroxidase thr thr 8 3-O- ribofuranosyl) S-adenosyl-L-methionine cycle I nadE adenosylcobalamin/alpha- cyclohydrolase ammonia- a 5,10- cyclohydrolase FolD: folD N -octanoyl-L-lysine hydrogenlyase: acquisition c-type: oleate C9E50_RS05010 synthase: otsA C9E50_RS23125 2' nucleotidase/ bifunctional [+ 2 isozymes] subunit: hyaB serine serine nicotinamide riboside) dimethylbenzimidazole dimethylbenzimidazole a [lipoyl-carrier nicotinate adenine -cysteine nudC a 5-methyltetrahydrofolate bifunctional diphosphatase: spoT bisphosphokinase: phnN synthase B: cysM a (3Z)-alk-3-enoyl-CoA C9E50_RS18745 ligase pgaC nucleosidase: ppnN reductase: nrdD semialdehyde PcnB: pcnB carbonate KatP: katP selenate biotin synthase: nicotinamide + adenosylcobinamide- dependent hycC hycD PRPP [+ 4 isozymes] phosphatase Cca: cca isochorismatase/ methyltransferase: multifunctional phosphoribosyltransferase: phosphoribosyltransferase: NAD 6 NMN ribazole phosphatase: 7,8-dihydroneopterinI FolE: folE methylenetetrahydrofolate lipoyl thiosulfate napA napB CMP a 1,2-diacyl- dehydrogenase: dehydratase: + protein]-N -[(R dinucleotide nicotinamide- ligase: gshA methylenetetrahydrofolate 10 cysteine hydrogen sulfide a phosphate argininosuccinate acyl-CoA RfaL: rfaL a proteinogenic formaldehyde RS03610 C9E50_RS19345 NADP transcriptional GDP C9E50_RS20345 NAD(+) an N -formyltetrahydrofolate uroporphyrinogen-III Glycolysis hycF hycG α α 2',3'-cyclic-nucleotide aryl carrier sn-glycerol C9E50_RS08145 cobT cobT 3'-triphosphate serine synthase: lipA PRPP disproportionation nitrite ∆ 3 2 , -trehalose β asp putA C9E50_RS23605 + 5-methoxy-6- SAM )-lipoyl]-L-lysine nucleotide glutamate-- nicotinate adenine dinucleotidesynthetase: nadE NMN methionine dehydrogenase/ GDP adenine synthase A: cysK biosynthesis I monoester lyase: argH synthetase: -cis-∆ -trans- L-phenylalanyl- D-ribofuranose a 2'- succinate -D-glucose amino acid a dipeptide a sugar RS25800 a sugar thr thr NADP regulator/nicotinamide- adenine ribotide ribazoletransferase: uroporphyrinogen-III C- acid ammonium a mature peptidoglycan a nascent peptidoglycan Phe poly-β-1,6- 2'-phosphodiesterase: protein EntB: entB L-homocysteine MeOH 3-phosphate a peptide H O methylbenzimidazole amidase: pncC hydroxymethyltransferase: a [lipoyl-carrier H phosphoribosyltransferase: IV (rhodanese) Cofactor, Prosthetic Group, Electron Carrier Degradation a tRNA 6-phosphate UDP triphosphate 6-phosphate RNA 2 biotin adenosylcobalamin dihydroneopterin cysteine ligase: synthase: metH methenyltetrahydrofolate 2 C9E50_RS01835 enoyl-CoA L-lysyl-[protein] GDP 2'-deoxyguanosine 5-phosphate deoxyribonucleoside leu RS11725 leu ubiquinol-8 phosphatase: nucleotide phosphate cobS nicotinate-nucleotide 6 methyltransferase: hemX glycolysis III (from glucose) adenine phosphatase cytochrome with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) di-trans,octa-cis N-acetyl-D- hypoxanthine cpdB [+ 2 isozymes] glu protoporphyrin IX ribotide phosphate triphosphate 2'- C9E50_RS06570 cyclohydrolase FolD: folD protein]-N -[(R)- glycolysis I (from glucose 6-phosphate) C9E50_RS21125 E. coli M phoA Coα-[α-(5- nicotinamide C9E50_RS20645 phosphoribosyltransferase: cys thiosulfate carbamoyl- c nitrite [+ 3 isozymes] isomerase: LPS -undecaprenyl 5'-triphosphate adenylyltransferase/ methionine adenylyltransferase: nicotinate-nucleotide dihydrolipoyl]-L-lysine uroporphyrinogen-III C- cys AphA: aphA L-arginino- meso-2,6-diaminopimeloyl- with GlcNAc terminus glucosamine 3'-GMP CO H O + adenosylcobinamide- adenosylcobinamide- methoxybenzimidazolyl) mononucleotide epimerase: folX L-ornithine phosphate fadJ heme degradation V 2 2 NAD ribosylnicotinamide deferrochelatase/ menaquinol-7 biosynthesis nadD adenylyltransferase: methylenetetrahydrofolate methyltransferase: cobA C9E50_RS21125 diphosphate phosphate succinate reductase heme D-alanine) tetrapeptide diphosphate a seryl-[EntF a sugar RS04455 a sugar GDP GDP adenosyltransferase: metK ]-Coβ-adenosylcobamide deamidase-related γ 5-formyltetrahydrofolate folate polyglutamylation D-glucopyranose D-glucopyranose synthase: carB oleoyl-CoA kinase NadR: nadR peroxidase EfeB: efeB 7,8-dihydromonapterin -L-glutamyl- nadD dehydrogenase: folD precorrin-1 thiosulfate subunit degradation IV L-seryl-carrier ala RS05975 ala NAD(+) ribazoletransferase: ribazoletransferase: 5'-phosphate protein YfaY: cyclo-ligase: 6-phosphate diphosphate C9E50_RS24080 NMN ferrochelatase: 1,4-dihydroxy- triphosphate L-cysteine glucokinase: inorganic 3-mercaptopyruvate sulfurtransferase NrfD: nrfD acyl-CoA a (2E)-2-enoyl-CoA protoheme protein] lipoate diphosphatase: cobS cobS adenosylcobalamin/ C9E50_RS08050 prenylated FMNH glycine cleavage system C9E50_RS04635 uroporphyrinogen-III C- glucose-6- thiamine diphosphate thioredoxin Coα-[α-(adenin- C9E50_RS21095 Coα-[α-(5-methoxy-6- met SAH 2-naphthoate 2 bis(guanylyl molybdenum glutathione a 5,10- a (6S)-5- a tetrahydrofolate C9E50_RS07380 diphosphatase: YgaP: ygaP carbamoyl dehydrogenase: protoheme salvage I nudC alpha-ribazole 1,4-dihydroxy- biosynthesis NaMN bifunctional nicotinamide a tetrahydrofolate aminomethyltransferase methyltransferase: hemX Amine and Polyamine Biosynthesis phosphate inorganic 3-mercaptopyruvate ornithine ammonium a sugar RS08415 a sugar biosynthesis pathway multifunctional 9-yl)]-Coβ- methylbenzimidazolyl)]- cofactor) biosynthesis synthase: methenyltetrahydrofolate formyltetrahydrofolate C9E50_RS25075 phosphate C9E50_RS22700 3-hydroxybutyryl- hematinate- protoheme phosphatase: 2-naphthoate nicotinamidase/ GcvT: gcvT uroporphyrinogen-III C- D-glucopyranose isomerase: diphosphatase: sulfurtransferase: [+ 3 isozymes] carbamoyltransferase: long-chain- acyl-CoA anaerobilin a [ribosomal trimethylamine trimethylamine a 2'- cytidine 2',3'-cyclic adenosine a trans-delta2- val RS05900 val II (Bacillus) NMN transcriptional adenosylcobamide Coβ-adenosylcobamide 5'-methylthioadenosine/ MoO - gshB argininosuccinate enoyl-CoA CoA a 2,3,4-saturated (3R forming heme a sulfurated an [HPr]- phosphoenol a reduced c- a reduced an N-modified 1-butanesulfonate lysine within (R)-lipoate sn-glycerol an aromatic an ADP-sugar NADH phytol ethanol α-amylose (R)-lipoate C9E50_RS20345 polyprenyltransferase: prenol 2 [+ 2 isozymes] serine bifunctional superpathway of arginine and polyamine biosynthesis 6-phosphate C9E50_RS26245 C9E50_RS25075 argF acyl-CoA a 2,3,4-saturated fatty-acid-- dehydrogenase: synthase: protein S12] a charged tRNA a peptidyl-[tRNA] deoxyribonucleoside monophosphate 2',3'-cyclic a peptide 4-hydroxy-L-threonine cis-delta21- an oxidized regulator/nicotinamide- 5-methyltetrahydropteroyltriglutamate- S-adenosylhomocysteine NaMN DMAPP molybdopterin D-threo-7,8- pyrazinamidase: bifunctional methyltransferase: cobA cadaverine biosynthesis phosphate sseA synthase: argG hydratase: oxygenase L-histidine pyruvate type cytochrome N-oxide TorC protein N-oxide [DNA] aminoacyl-[tRNA] gcv protein H 3-phosphate amino acid lipoate-- HMP-PP 5'-phosphate 5'-phosphate Coα-[α-(5- menA glutathione hydroxymethyltransferase: tetrahydrofolate spermidine biosynthesis III glucose-6- dehydrogenase: fatty acid CoA ligase C9E50_RS12270 epimerase: fadB )-3-hydroxyacyl-CoA C9E50_RS01565 [sulfur carrier] L-aspartate 89 5'-triphosphate fused tRNA monophosphate C40:2-[acp] zinc-binding catalase/ 1,4-alpha- thioredoxin bifunctional UDP- nucleotide adenosylcobalamin/ - homocysteine S- nucleosidase: mtnN cofactor dihydroneopterin nicotinate pncA formyltetrahydrofolate methylenetetrahydrofolate thiocyanate sulfite L-citrulline fadB ChuS: chuS fused tRNA bifunctional 3- anaerobic glycerol- aspartate/ predicted protein thiamine adenosylcobalamin/ methoxybenzimidazolyl) demethylmenaquinol-7 bis(molybdenum C9E50_RS06570 synthase/ 10 precorrin-2 F6P phosphate hydrogen sulfide C9E50_RS12270 FadD: fadD nucleotidyltransferase/ peroxidase glucan sugar hydrolase/ adenylyltransferase/ an N - phosphate acyl-CoA Fe 3+ 3-phosphate ADP alcohol ABC alpha-ribazole alpha-ribazole methyltransferase: metE β isopentenol cofactor) dihydromonapterin phosphoribosyltransferase: deformylase: purU dehydrogenase/ phosphoenolpyruvate- nucleotidyltransferase/ FMNH2-dependent hydroxydecanoyl- lipoate-- tyrosine/aromatic NAD(+) branching ligase phosphate ]-Co -adenosylcobamide dihydrofolate formyltetrahydrofolate glu isomerase: (2E,9Z)- [+ 3 isozymes] a 2,3,4-saturateddehydrogenase: a 2,3,4-saturated (3S 2+ DNA polymerase 2',3'-cyclic Xaa-Pro low-specificity dehydrogenase: HPI: katG a sugar a sugar 5'-nucleotidase: ribosylnicotinamide phosphatase: phosphatase: methionine synthase: metH bifunctional kinase: thiM synthase: mobA reductase: folM pncB methenyltetrahydrofolate precorrin-2 SAM arg lys 6-phosphofructokinase anaerobilin Fe 30S ribosomal -protein bifunctional trimethylamine- trimethylamine- 2',3'-cyclic aminoacyl-tRNA alkanesulfonate ACP dehydratase/ protein ligase dehydrogenase: aminotransferase: compounds diphosphatase: transporter LplA: lplA synthase: thioredoxin- acyl carrier protein metabolism L-homocysteine S-ribosyl-L-homocysteine bis(molybdenum a 5,10- synthase: folC C9E50_RS26245 class II fructose- octadecenoyl-CoA fatty acyl CoAC9E50_RS22700 )-3-hydroxyacyl-CoA III subunit theta: phosphodiesterase/ aminopeptidase: L-threonine C9E50_RS14610 catalase/ enzyme: C9E50_RS21070 kinase NadR: nadR C9E50_RS20345 C9E50_RS20345 demethylmenaquinone nicotinate cyclohydrolase FolD: folD bifunctional dehydrogenase: cobA amino-acid N- lysine decarboxylase II: pfkB 3-hydroxyacyl-CoA protein S12 phosphotransferase: ptsP glycosyl N-oxide N-oxide phosphodiesterase/ hydrolase: monooxygenase: trans-2- LplA: lplA glpC glpA C9E50_RS18535 hydrolase nudC of a sugar (lipoyl)adenylate thiE disulfide β thiamine α α cofactor) 5,6,7,8- methylenetetrahydrofolate bisphosphatase: enoyl-CoA C9E50_RS11500 2' nucleotidase/ pepP aldolase: ltaE alcohol peroxidase glgB thiamine 1-( -D Coα-[α-(adenin- Co -[ -(5-methoxy-6- guanylyl molybdenum methyltransferase/2- NAD NAD phosphorylation tetrahydrofolate glutathione-peroxide arginine LdcC: ldcC dehydrogenase: methylthiotransferase transferase/ reductase reductase 2' nucleotidase/ C9E50_RS15575 ssuD decenoyl-ACP glycerol-3- NudE: nudE + tetrahydromonapterin lipoate biosynthesis acetyltransferase: adenosylmethionine F6P class II fructose- 6-phosphofructokinase: anaerobilin anaerobilin [+ 3 isozymes] phosphatase Cca: cca aromatic amino reductase: ribofuranosyl) NAD β salvage I methyl-benzimidazolyl)]- phosphorylation and prenyl phosphate molybdenum cofactor and dephosphorylation bifunctional redox reactions glpX hydratase: transpeptidase: TorA: torA TorA: torA [+ 11 isozymes] dehydrogenase KatP: katP amylopectin D-ribose RS25805 D-ribose lipoate-- phosphate 7-yl)]-Co - a holo acyl- cofactor biosynthesis methoxy-6-polyprenyl- an N 10 -formyltetrahydrofolate a tetrahydrofolate synthase/ sirohydrochlorin C9E50_RS05210 decarboxylase: lysine decarboxylase bisphosphate pfkA fadB RimO: rimO phosphatase Cca: cca aminoacyl-tRNA isomerase: fabA a [glycine-cleavage phosphate acid transaminase: reduced β- trxB nicotinamide Coβ-adenosylcobamide demethylmenaquinol- transhydrogenation guanylyltransferase and incorporation I tetrahydrofolate decarboxylase: speD fadB coenzyme A reductase: reductase: mrcB 2',3'-cyclic-nucleotide a cis,cis-delta3,21- AdhP: adhP acetaldehyde protein adenosylcobamide carrier protein demethylmenaquinol- 1,4-benzoquinol dihydrofolate adiA CadA: C9E50_RS25570 6-phosphofructokinase DHAP hydrolase: 6 dehydrogenase: α thiamine- S-ribosylhomocysteine MoO - 9 biosynthesis + aldolase: fbaAβ chuY chuY an [HPr protein]- 2',3'-cyclic-nucleotide glycolaldehyde complex H protein] N C9E50_RS25990 an -D-aldose nicotinamide D- thiamine 2 MobA: mobA NAD synthase/ GSSG cadaverine -D-fructose 1,6- acetyl-CoA C- 2'-phosphodiesterase: a proteinogenic C40:2-[acp] an aromatic AMP ligase 6 biosynthesis I molybdopterin methylase UbiE: ubiE NAD + glutathionylspermidine synthase: folC sirohydrochlorin N-acetyl-L-glutamate dAdoMet II: pfkB (S)-3-hydroxy-(9Z) a [ribosomal π pyruvate 2'-phosphodiesterase: C9E50_RS22975 a peptide gly 1-butanal sulfite C9E50_RS02140 1-phosphate ribonucleotide phytenal phosphate thiamine lyase: luxS all-trans- bis(guanylyl an octanoyl-[acp] dihydrofolate biosynthetic bisphosphate an unsulfurated N -phospho- an oxidized c- trimethylamine an oxidized trimethylamine [DNA] cpdB amino acid -[(R)-lipoyl]-L-lysine AMP biosynthesis 10 ferrochelatase: cobA allantoin degradation IV (anaerobic) Amine and Polyamine Degradation -octadecenoyl-CoA acyltransferase 5'-deoxyadenosine 2-oxo-acid LplA: lplA kinase: thiL kinase: all-trans- cofactor molybdenum cofactor 1,4-dihydroxy- NAD(+) molybdopterin) an N - arginine 6-phosphofructokinase: triose- superpathway of N-acetylglucosamine, N-acetylglucosamine D-carnitine met protein S12]-3- L-histidine a peptidyl- an uncharged cpdB DHAP predicted a [lipoyl-carrier a reduced holo-ACP 1,4-dihydroxy- nonaprenyl menaquinol-7 tetrahydropteridine recycling lipoyl(octanoyl) synthase: folC 4-aminobutanoate 3-hydroxyacyl-CoA a 2,3,4-saturated FadI: fadI a 2,3,4-saturated β-anaerubin δ-anaerubin [sulfur carrier] type cytochrome TorC protein 3'-cmp menaquinol-6 biosynthesis ACP thiK hexaprenyl guanylyltransferase 2-naphthoate kinase: nadK prenylated FMNH cofactor formyltetrahydrofolate acetylglutamate decarboxylase: pfkA phosphate superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass N-acetylmannosamine and N- degradation II degradation II methylsulfanyl- aminoacyl-[tRNA] tRNA 3'-AMP ABC 6 thiamine thioredoxin diphosphate 2 transferase siroheme degradation III 89 an N-modified an uncharged protein]-N -[(R menaquinol-9 biosynthesis synthase: thiamine cytidylyl molybdenum 2-naphthoate + Re/Si-specific glutathione spermidine a 5,10- glutathione- β dehydrogenase: fatty acyl CoA acetyl-CoA C- 3-oxoacyl-CoA L-aspartate D-ribose D-ribose diphosphate acyl carrier phosphodiesterase: diphosphate MobA: mobA NADP NADP + NAD(+) glutathione kinase: argB speA -D-fructose 1,6- isomerase: (S)-(+)-allantoin acetylneuraminate degradation N-acetyl-D- fatty acid β- transporter )-lipoyl]-L-lysine C9E50_RS06505 phosphate cofactor biosynthesis a 4a-hydroxytetrahydropteridine a [lipoyl-carrier protein]LipB: lipB NAD(P)(+) methylenetetrahydrofolate disulfide fadB acyltransferase amino acid tRNA demethylmenaquinol-6 protein activation acpH molybdopterin- 1,4-dihydroxy- phosphatase: kinase: peroxidase: bisphosphate tpiA glucosamine D-carnitine 4-aminobutanoate oxidation III of D-ribose [+ 2 isozymes] MoO - 1,4-dihydroxy- Re/Si-specific N 6 -octanoyl-L-lysine transhydrogenase: reductase: agmatine D-glucopyranose 6-phosphate N-acetylneuraminate N-acetylglucosamine 3-oxo-(9Z)- FadA: fadA demethylmenaquinol-9 thiamine- 2 guanine 2-naphthoate phoA nadK bifunctional C9E50_RS12195 N-acetylglutamyl-phosphate (unsaturated, bifunctional N-acetylneuraminate L-carnitine degradation I 4-aminobutyrate- 2+ 2+ an apo acyl- molybdopterin 2-naphthoate NAD(P)(+) pntA pntB gorA class II fructose- kinase: nagK octadecenoyl-CoA Co Co bifunctional phosphate dinucleotide polyprenyltransferase: lipoyl glutathionylspermidine D-glyceraldehyde glucose-6-phosphate -2-oxoglutarate odd number) 34 a 2'- an [RNA] 2''-O-acetyl- a (1->4)- RS09155 demethylmenaquinone carrier protein polyprenyltransferase: polyamine lyase: nanA N-acetyl-D- a (3Z)-alk-3- a 5,10- a 2-thiouridine a single D-threo-7,8- a 1-acyl-sn-glycero- salicin 6- a trans-delta2- a siderophore- Ni 2+ Ni 2+ holo-ACP kinase: thiL cofactor molybdenum cofactor menA transhydrogenase: a 6,7-dihydropteridine synthase: lipA amidase/synthase: N-acetyl- bisphosphate 3-phosphate isomerase: N-acetyl-D- acetyl-CoA C- hydrogen cyanide a sulfurated dithioerythritol thiosulfate (S)-2- ADP-D-ribose N-acetyl- cyanate α demethylmenaquinone methyltransferase/2- biosynthesis glucosamine L-carnitine transaminase: methylenetetrahydrofolate in tRNA stranded DNA dihydroneopterin deoxyribonucleoside [DNA] 3-phosphocholine glu containing phosphate a tRNA precursor cis-delta15- ADP-ribose L-threo-3-phenylserine bound Fe(III) ethylphosphate -D-glucan an apo acyl- cytidylyltransferase: menA pntA pntB gamma-glutamyl- aminopropyltransferase: aldolase: fbaA allantoate mannosamine L-carnitine enoyl-CoA∆ 3 ∆ 2 [sulfur carrier] ATP aminobutanoate L-citrulline methyltransferase/2- methoxy-6-polyprenyl- synthase: thiamine guanylylprotein B: mobB a [lipoyl-carrier C9E50_RS04185 type I C9E50_RS26245 6-phosphate gabT acyltransferase -cis- 5'-triphosphate cob(II)alamin cytidine C34:2-[acp] 1,4-alpha- carrier protein cytidylyl oxygen-insensitive 6 + speE bifunctional 3- acid methoxy-6-polyprenyl- C9E50_RS06505 diphosphate mocA molybdenum protein]-N -[(R)- NADP glutathione phosphate allantoate N-acetylmannosamine ethanolamine utilization FadA: fadA -trans- acetyl-CoA glucan 1,4-benzoquinol molybdenum demethylmenaquinol-9 NADPH NAD(P)H glyceraldehyde- F6P N-acetylglucosamine- 4-aminobutyrate hydroxydecanoyl- O-acetyl-ADP- ADP-ribose phosphatase [+ 2 isozymes] cofactor dihydrolipoyl]-L-lysine reductase: argC S-methyl-5'- N 1 -(3-aminopropyl) kinase: crotonobetaine/ enoyl-CoA tRNA uridine-5- thiosulfate bifunctional multifunctional acyl- 6-phospho-beta- NADPH- branching predicted 1,4-benzoquinol methylase UbiE: ubiE a holo acyl- cofactor demethylmenaquinol-6 nitroreductase: nfsB glutathionylspermidine triose- 3-phosphate deiminase: 6-phosphate transaminase: acetyl-CoA C- rhodanese: DNA polymerase glutamate- ACP dehydratase/ ribose deacetylase: low-specificity pyrophosphatase: acetylornithine AphA: aphA cyanase: N-acetyl-L-glutamate thioadenosine agmatine C9E50_RS03065 carnitine-CoA isomerase: carboxymethylaminomethyl(34) VII large subunit: xseA reductase dihydroneopterin CoA ribonuclease I: glucosidase: ribonuclease D: dependent enzyme: ATP-driven methylase UbiE: ubiE menaquinol-6 phosphate dehydrogenase: allC ethanolamine deacetylase: nagA C9E50_RS14665 acyltransferase C9E50_RS13690 III subunit theta: ethanolamine -cysteine C9E50_RS16935 L-threonine C9E50_RS03960 deacetylase: cynS Ni 2+ Ni 2+ carrier protein 6-phosphofructokinase N-acetyl-D- 3-dehydrocarnitine succinate fadJ synthesis enzyme MnmG: mnmG exodeoxyribonuclease cytochrome aldolase/7,8- I/protease I/ C9E50_RS20475 C9E50_RS05735 C9E50_RS11695 trans-2- ferric chelate alkaline glgB transporter menaquinol-9 a 5,6,7,8-tetrahydropteridine 5-semialdehyde isomerase: gap class II fructose- N-acetylglucosamine- ligase: caiC FadI: fadI thiosulfate C9E50_RS11500 utilization cob(I)yrinic ligase: gshA aldolase: ltaE argE II: pfkB (S)-ureidoglycine mannosamine ethanolamine semialdehyde a (2E)-2- VII small subunit: xseB B subunit: dihydroneopterin lysophospholipase [+ 2 isozymes] decenoyl-ACP reductase: phosphatase: of Ni2+ succinylornithine/ tpiA bisphosphatase: glpX 6-phosphate tRNA uridine-5- sulfurtransferase acid a,c-diamide starch Hormone Biosynthesis D-glyceraldehyde 6-phosphofructokinase: pfkA 6-phosphate ammonia- (7Z)-hexadecenoyl-CoA enoyl-CoA superpathway of N-acetylneuraminate degradation Carboxylate Degradation C9E50_RS12400 epimerase: folB [+ 11 isozymes] L1: tesA glutamate-- isomerase: fabA D-ribofuranose nfeF phoA acetylornithine DHAP 13-DPG deacetylase: nagA succinate- 2-methylcitrate cycle I pyruvate fermentation carboxymethylaminomethyl(34) GlpE: glpE adenosyltransferase a 5'-hydroxy- an [RNA]-3'- a cis,cis-delta3,15- acetate ADP-D-ribose ammonium CO 3-phosphate (S)-ureidoglycine N-acetylmannosamine- lyase: eutB eutC cysteine ligase: a nucleoside 5'- 5-phosphate ethanol 2 2+ 2+ transaminase: astC spermidine DHAP β-D-fructose 1,6-bisphosphate semialdehyde L-ascorbate to acetate II synthesis GTPase MnmE: mnmE a single-stranded EutT: eutT ribonucleotide- cytidine-3'- β-D-glucose a tRNA C34:2-[acp] benzaldehyde AMP acetate Ni RS09150 Ni ethylene biosynthesis III (microbes) type I aminohydrolase: 6-phosphate D-glucosamine acyl-CoA a ribonucleoside C9E50_RS20645 salicyl alcohol monophosphate gly L-citrulline hydrogencarbonate indole-3-acetate phosphoglycerate L-carnitinyl-CoA dehydrogenase: N-acetylneuraminate degradation I oligodeoxyribonucleotide 4,5-cis-dihydroxy- 6-(hydroxymethyl) [DNA] sn-glycero-3- 3'-[RNA] phosphate 6-phosphate allE acetaldehyde 6-phosphate crotonobetainyl- trimethylaminoacetone dehydrogenase: propanoate 5'-monophosphate an unsulfurated sulfite glycolaldehyde a carboxylate Fe 2+ a siderophore Fatty Acid and Lipid Biosynthesis N-acetyl-L-ornithine glyceraldehyde- kinase: class II fructose- 2-epimerase: gabD (bacterial, anaerobic) pyruvate thiocyanate a siderophore- biosynthesis triose-phosphate CoA C9E50_RS22700 N-acetylneuraminate a 5-aminomethyl-2- [sulfur carrier] 1,2-dithiacyclohexane -7,8-dihydropterin phosphocholine superpathway of L- Amino Acid Biosynthesis carbamoyl- 3-phosphate C9E50_RS04555 bisphosphate aldolase: fbaA (S)-ureidoglycolate C9E50_RS03060 L-carnitine L-ascorbate a 7,8-dihydrofolate γ-L-glutamyl-(S)- Co 2+ Co 2+ L-histidine biosynthesis superpathway of L-lysine, L-threonine and L-methionine biosynthesis I VI (bacteria) hydratase: caiD propionate- pyruvate thiouridine 34 in tRNA adenosylcobalamin superpathway of aromatic amino acid biosynthesis superpathway of L-tryptophan biosynthesis superpathway of L- superpathway of L- glycine superpathway of L-homoserine and L-methionine biosynthesis superpathway of branched chain amino acid biosynthesis glycine biosynthesis II phosphate bound Fe(III) dehydrogenase: isomerase: tpiA N-acetyl-D- succinate acyl-CoA lyase: nanA 6-phosphate 2+ RS20250 2+ isoleucine biosynthesis I acetylornithine 3-phospho- acetaldehyde ethanolamine CoA- -CoA dehydrogenase complex 2-aminobutanoate Mg Mg superpathway of fatty acids biosynthesis (E. coli) phenylalanine biosynthesis tyrosine biosynthesis biosynthesis IV synthase: carB gap glucosamine dehydrogenase: superpathway of lipopolysaccharide biosynthesis phosphatidylglycerol acyl-CoA hydrolysis deacetylase: argE trp D-glycerate ureidoglycolate malate/lactate/ dehydrogenase utilization ethanol α-D-glucosamine transferase: N-acetyl-D-mannosamine ligase: prpE dihydrolipoyllysine-residue superpathway of acetate D-erythrose D-erythrose a [glycine-cleavage C9E50_RS24080 6-phosphate C9E50_RS12270 biosynthesis II (non-plastidic) oxaloacetate PRPP oxaloacetate D-erythrose phosphoenol pyruvate 6 D-glyceraldehyde 3-phosphate dehydrogenase: ureidoglycolate (acetylating): dehydrogenase 6-phosphate caiB phosphoenolpyruvate D-erythrose phosphoenol asp thr complex H protein] N - 2,3- N-acetylglucosamine- γ-butyrobetainyl- crotonobetainyl- glycine betaine [+ 4 isozymes] 3-keto-L-gulonate acetyltransferase: aceF utilization and formation an E. coli an all-trans- GMP-N-ε-(N-α-acetyl 3''-O-acetyl- GDP-α-D- acetyl-CoA a 2,3,4-saturated aspartate/ 4-phosphate 4-phosphate thr 13-DPG allD C9E50_RS21710 EutG: eutG (2E,7Z)- N-acetylmannosamine an L-1- a peptidoglycan dimer (meso 1-(oleoyl)-sn-glycero-3- arbutin-6- D-gluconate a supercoiled 2+ 2+ a (3R)-3- ATP 4-phosphate pyruvate 4-phosphate pyruvate aminomethyldihydrolipoyl- glycine cleavage system L-ornithine a siderophore- 2,3-bisphosphoglycerate- diphosphoglycerate- dehydrogenase: glucosamine- CoA CoA 6-phosphate acetyl-CoA a 5-L-glutamyl- a protein with glutathione 1,4-dihydroxy- lysine methyl ester) 2,3- a tripeptide γ-L-glutamyl-(S)- (R)-NADPHX citrate Co RS27385 Co UDP-N-acetyl- DHAP aspartate/ acetolactate carbamoyl phosphate type I glyceraldehyde- 6-phosphate osmoregulated an amino acid -diaminopimelate containing) phosphoethanolamine polyisoprenyl ser phosphate gly 6-phosphate ADP-ribose L-allo-threonine mannose duplex DNA D-serine 2+ 2+ hydroxytetradecanoyl-[acp] fatty acyl CoA tyrosine/aromatic 3-deoxy-7- low-specificity bifunctional aspartate aminomethyltransferase (indol-3- independent malate/lactate/ C9E50_RS19215 [+ 2 isozymes] allantoin degradation hexadecenoyl-CoA kinase: propanoyl-CoA acetate phosphatidylethanolamine [peptide] a disulfide bond inosine XTP Mg Mg acetyl-CoA α-D-glucosamine multifunctional acyl- 3-deoxy-7- phosphoribosyltransferase: tyrosine/aromatic threonine synthase: L-lysine bound Fe(II) phosphoglycerate dependent 3-phosphate deacetylase: nagA 6-phosphate 3-keto-L- phosphate periplasmic 2-naphthoate diphosphate 5'-phosphoramidate dihydroxybenzoate 2-aminobutanoate fructose-1- bifunctional ATP- NAD(P)H- aminotransferase: phosphoheptulonate 3-deoxy-7- 3-deoxy-7- L-threonine kinase/homoserine gly GcvT: gcvT yl)pyruvate phosphoglycerate ureidoglycolate ureidoglycolate to glyoxylate III L-carnitine degradation III enoyl-CoA C9E50_RS03065 XTP/dITP D-serine carboxylase, CoA thioesterase phosphoheptulonate hisG aminotransferase: ammonia- ilvN ilvI L-methionine biosynthesis II (plants) glycine cleavage system kinase: phosphoglycerate dehydrogenase: gap N-acetylglucosamine- acetyl-CoA deaminase: gulonate-6- acetyltransferase: pta glucan (OPG) phosphate/6- ADP-dependent dependent long-chain fatty dependent C9E50_RS18535 synthase AroF: aroF phosphoheptulonate phosphoheptulonate aldolase: ltaE dehydrogenase I: thrA [+ 2 isozymes] ornithine mutase: gpmM dehydrogenase: dehydrogenase: hydratase: 2-methylcitrate ethanolamine serine-type multifunctional acyl- 6-phospho-beta- O-acetyl-ADP- GDP-mannose citrate lyase diphosphatase: ammonia- carboxyltransferase acyl-ACP--UDP-N- I/protease I/ synthase AroF: aroF 1-(5-phospho- C9E50_RS18535 lyase, aminomethyltransferase C9E50_RS04555 mutase: gpmA 6-phosphate ethanol nagB (S)-(+)-allantoin N-acetyl-D-mannosamine phosphate acetate- gamma- purine nucleoside peptidase glutathione phosphogluconate low-specificity NAD(P)H-hydrate DNA acid activation glycerol-3- asp [+ 2 isozymes] synthase AroF: aroF gly [+ 3 isozymes] phosphate fadB synthase: prpC phosphate utilization phosphoethanolamine D-Ala-D-Ala CoA thioesterase glutaredoxin 1,4-dihydroxy- enterobactin ribose deacetylase: pyrophosphatase lyase: 2+ 2+ subunit beta: accD acetylglucosamine O- lysophospholipase β synthase AroF: aroF [+ 2 isozymes] biosynthetic: GcvT: gcvT carbamoyltransferase: 13-DPG C9E50_RS19215 allD crotonobetainyl- L-carnitine 6-phosphate decarboxylase -CoA ribonucleoside T: pepT glucosidase: phosphatase: yqaB dehydratase/ subunit helicase C9E50_RS04400 Mg RS24995 Mg phosphate 3-deoxy-D-arabino- [+ 2 isozymes] -D-ribosyl)-ATP L-homoserine 3-phospho- 2-phospho- deacetylase: nagA acetyltransferase: pta F6P acetyltransferase: acetate kinase transferase: glutamyltransferase: carboxypeptidase I/protease I/ 2: grxB 2-naphthoate phosphoramidase: non-ribosomal synthase: C9E50_RS16935 L-threonine NudK: nudK dsdA acyltransferase: lpxA L1: tesA [+ 2 isozymes] [+ 2 isozymes] ilvA (S)-2-acetolactate [+ 2 isozymes] argF 2+ (indol-3-yl) N-carbamoyl- CoA (S)-3-hydroxy-(7Z) (2S,3S)-2- ligase: acs hydrolase C9E50_RS05735 alpha: citF RecQ: recQ [+ 2 isozymes] acetyl-CoA a long-chain fatty acid dehydrogenase: bifunctional heptulosonate bifunctional asp Fe D-glycerate D-glycerate D-glucosamine N-acetylmannosamine- UlaD: ulaD C9E50_RS07825 EutP: eutP C9E50_RS17390 C9E50_RS02025 DacD: dacD [+ 2 isozymes] polyprenyltransferase: hinT peptide gshB 6-phosphogluconate aldolase: ltaE NAD(P)H-hydrate pyruvate [+ 2 isozymes] 3-deoxy-D-arabino- L-aspartyl-4-phosphate a [glycine-cleavage a [glycine-cleavage acetaldehyde 2-oxoglycine phosphate dehydrogenase: -hexadecenoyl-CoA methylcitrate lysophospholipase RihC: rihC [+ 2 isozymes] [+ 2 isozymes] carboxylase gpsA a 2,3,4-saturated aspartate kinase/ 7-phosphate phosphoribosyl- 3-deoxy- 3-deoxy- bifunctional phosphopyruvate phosphoglycerate 6-phosphate allantoate 6-phosphate L-xylulose [+ 3 isozymes] menA synthetase phosphatase: yieH epimerase: α [+ 4 isozymes] XMP UDP-3-O-[(3R)-3- long-chain- sn-glycerol heptulosonate bifunctional ketol-acid complex H protein] N 6 complex H protein] N 6 2,3- acetyltransferase: caiA carnitine 3-hydroxyacyl-CoA 2-methylcitrate [+ 4 isozymes] [+ 2 isozymes] L1: tesA ADP-D-ribose -D-mannose a single carboxyl fatty acid homoserine AMP D-arabino- D-arabino- threonine homoserine kinase: thrB 2,3-bisphosphoglycerate- hydratase: kinase: C9E50_RS04555 2-epimerase: 5-phosphate acetyl phosphate acetyl phosphate acetyl-CoA an α-(5-L- EntF: entF a proteinogenic a dipeptide D-gluconate acetate C9E50_RS25380 galactitol RS09245 galactitol hydroxymyristoyl]-N- fatty-acid-- 3-dehydroquinate aspartate-semialdehyde reductoisomerase: -[(R)-lipoyl]-L-lysine -dihydrolipoyl-L-lysine asp L-citrulline diphosphoglycerate- C9E50_RS07825 monooxygenase: dehydrogenase: dehydratase: an E. coli osmoregulated a protein with α β GMP 1-phosphate stranded DNA transferase 3-phosphate 7-phosphate aspartate kinase/ ammonia- independent allantoate C9E50_RS03060 a 1,2-diacyl- glutamyl)- GSSG N- -acetyl lysine amino acid -D-glucose ophthalmate acetaldehyde (S)-NADPHX acetyl-α-D-glucosamine CoA ligase dehydrogenase synthase: aroB cyclohydrolase/ heptulosonate heptulosonate dehydrogenase: ilvC dependent C9E50_RS05410 urea degradation II yeaX yeaW fadB prpD L-ribulose-5- periplasmic glucan with a peptide a peptidoglycan with reduced L- GMP D-ribofuranose [+ 2 isozymes] hydroquinone gly acetate oxaloacetate subunit D-ribulose 5-phosphate glycerol-3- 3-dehydroquinate homoserine lyase/L- phosphoglycerate 3-phospho-D-glycerate deiminase: allC N-acetyl-D-glucosamine ethanolamine utilization sn-glycerol amino acid sn-glycero-3- DMKH methyl ester 6-phosphate UDP-3-O-acyl-N- FadD: fadD I: thrA phosphoribosyl- 7-phosphate 7-phosphate (2R)-2,3- superoxide phosphoglycerate phosphoenol α acetyl phosphate phosphate 3- D,D cross-links (meso- D-ala oleate cysteine residues 2 hypoxanthine alpha: accA phosphate 1-O- synthase: aroB dehydrogenase C9E50_RS07715 serine O-phospho-L-homoserine (indol-3-yl)acetate mutase: gpmM -D-glucosamine 3-oxo-(7Z)- 6-phosphate cis-2- acetate kinase EutP: eutP phosphotidylethanolamine phosphoethanolamine acetylglucosamine [+ 3 isozymes] [+ 2 isozymes] 3-dehydroquinate ATP diphosphatase 3-dehydroquinate 3-dehydroquinate dihydroxy-3- argininosuccinate mutase: gpmA pyruvate carbamoyl oxamate L-malic epimerase UlaE: diaminopimelate containing) L-cystine RS12100 L-cystine arabinose-5- a long-chain acyltransferase: I: thrA aspartate-semialdehyde ammonia- 2,3-bisphosphoglycerate- 2,3-diphosphoglycerate- 6-phosphate urea (S)-ureidoglycine trimethylamine hexadecenoyl-CoA methylaconitate [+ 3 isozymes] substituent deacetylase: lpxC HisIE: synthase: aroB synthase: aroB methylbutanoate synthase: argG superoxide phosphate ethanolamine semialdehyde N-acetylglucosamine- C9E50_RS25230 enterobactin malonyl-CoA phosphate fatty acyl-CoA C9E50_RS26155 L-aspartyl- type I 3- 3-dehydroquinate [+ 2 isozymes] dehydrogenase: asd lyase cystathionine gamma- 2-phospho- pyruvate independent dependent glucosamine- urease: ureC acetyl-CoA C- bifunctional phosphate UDP-3-O-(3- C9E50_RS09585 dihydroxy-acid glycine cleavage system dismutase utilization acetate 6-phosphate L-ribulose 5- acetate isomerase 4-phosphate dehydroquinate TdcB: tdcB synthase: metB D-glycerate phosphoenolpyruvate kinase: pyk phosphoglycerate phosphoglycerate carbamate 6-phosphate C9E50_RS17370 (S)-ureidoglycine acyltransferase aconitate acetyltransferase: pta ACP S- hydroxymyristoyl) glycerol-3- type I 3- 1-(5-phospho-β- L-aspartyl- 3-dehydroquinate 3-dehydroquinate L-aspartate 4-semialdehyde dehydratase: aminomethyltransferase L-arginino-succinate [Fe]: sodB mutase: gpmM mutase: gpmA kinase: arcC kinase EutP: eutP aminohydrolase: deacetylase: nagA phosphate GutQ: gutQ α dehydratase: aroD met phosphopyruvate synthase: ppsA pyruvate kinase I: deaminase: C9E50_RS17375 FadA: fadA hydratase 2/2- phosphate UDP-N-acetyl- di-trans,octa-cis a thiocarboxylated cyclic γ L-cystine RS10955 L-cystine malonyltransferase: - -D-glucosamine phosphate 1-O- aspartate- dehydroquinate D-ribosyl)-AMP 4-phosphate (2Z)-2-aminobut- ilvD GcvT: gcvT [+ 2 isozymes] [+ 2 isozymes] [+ 3 isozymes] allE N-acetylglucosamine- L-ribulose-5- undecaprenyldiphospho- α D-glucopyranose α an N-formyl-L- all-trans- all-trans- uridine 2'3'-cyclic L-alanyl- -D- an [RNA] a PepB a (1->4)- a peptide with arabinose-5- UDP-3-O-(3- type I 3- type I 3- L-cystathionine hydratase: C9E50_RS12370 nagB ammonium acetyl-CoA C- methylisocitrate acetyltransferase: α-D-glucosamine -undecaprenyl UDP- -D-glucose ADP- -D-glucose [SAMP] C- pyranopterin 1,4-dihydroxy- 1,4-dihydroxy- O-ureido-L- α acetyl-CoA N-methyl-L- a (2E)-docos- propan-1-ol glyoxal fabD acyltransferase semialdehyde 3-dehydroshikimate dehydratase: aroD bifunctional aspartate 2-enoate 3-methyl-2- [+ 3 isozymes] argininosuccinate hydrogen 2-phospho-D-glycerate (S)-malate 6-phosphate phosphate 4- D-gluconate N-acetylmuramoyl-L- 6-phosphate methionylaminoacyl- dodecaprenyl decaprenyl monophosphate glutamyl-L-lysyl- containing uridine aminopeptidase asp -D-glucan an N-terminal a protein ITP phosphate hydroxymyristoyl) bifunctional dehydroquinate dehydroquinate methionine- C9E50_RS05410 acetate acyltransferase dehydratase: acnB C9E50_RS07825 γ phosphate terminal glycine phosphate 2-naphthoate 2-naphthoate fused tRNA homoserine tryptophan 2-enoyl-[acp] PlsY: plsY dehydrogenase: aspartate- kinase/homoserine oxobutanoate lyase: argH peroxide pyruvate carbamate F6P (S)-ureidoglycolate deacetylase: nagA epimerase: degradation alanyl- -D-glutamyl-meso tRNA diphosphate diphosphate D-alanyl-D-alanine substrate acetyl-CoA bifunctional 3- L-alanine zinc-binding beta-barrel isoprenoid ACP S- isomerase glucosamine N- 3-dehydroshikimate phosphoribosyl- dehydratase: aroD dehydratase: aroD oxo-acid phosphoenol FadI: fadI nucleotidyltransferase/ XTP/dITP a 1-acyl-sn C9E50_RS07715 shikimate semialdehyde dehydrogenase I: thrA phosphopyruvate NAD-dependent (2R,3S)-2- araD -2,6-diaminopimeloyl- alpha- carboxylase, hydroxydecanoyl- alcohol assembly- biosynthesis AI-2 RS12755 AI-2 malonyltransferase: KdsD: kdsD acyltransferase: AMP superpathway of L-methionine biosynthesis (transsulfuration) bifunctional maltose arg transaminase: pyruvate alpha,alpha- 2',3'-cyclic diphosphatase: -glycerol 3- dehydrogenase: dehydrogenase: 3-dehydroshikimate 3-dehydroshikimate 2-isopropylmalate branched-chain- arg hydratase: C9E50_RS05410 ureidoglycolate malic enzyme: D-glucosamine 6-phosphate methylisocitrate D-gluconate D-alanyl-D-alanine undecaprenyl- molybdopterin peptide 1,4-dihydroxy- 1,4-dihydroxy- serine-type ribonuclease I: amylase: carboxyltransferase N-methyl-L- ACP dehydratase/ dehydrogenase: enhancing glyoxalase C9E50_RS17525 aldehydo-D-arabinose lpxD aspartate- shikimate cyclohydrolase/ bifunctional aspartate regulon transcriptional ybdL (5Z)-tetradecenoyl-CoA L-ribulose-5- trehalose- phosphodiesterase/ aminopeptidase argininosuccinate aminopeptidase C9E50_RS04400 phosphate ydiB C9E50_RS07715 2-iminobutanoate synthase: leuA amino-acid pyruvate lyase: allA C9E50_RS13980 gluconokinase: phosphate glucose synthase deformylase: 2-naphthoate 2-naphthoate D-Ala-D-Ala C9E50_RS20475 malS subunit beta: accD tryptophan trans-2- C9E50_RS14610 protease: ElbB: elbB 5-phosphate UDP-2-N,3-O-bis[(3R)- 1-acyl-sn-glycerol- semialdehyde dehydrogenase: phosphoribosyl- kinase/homoserine repressor/cystathionine phosphoenolpyruvate phosphate 4- propanoyl CoA undecaprenyldiphospho- phosphate 2' nucleotidase/ PepB: pepB synthase: argG N: pepN [+ 2 isozymes] aspartate- shikimate shikimate oxaloacetate transaminase: 4-(methylsulfanyl) kinase: pyk acyl-CoA methylisocitrate gntK phosphotransferase: catalytic subunit C9E50_RS02745 polyprenyltransferase: polyprenyltransferase: carboxypeptidase [+ 3 isozymes] oxidase: solA decenoyl-ACP alcohol C9E50_RS06885 glycolate a malonyl-[acp] 3-hydroxytetradecanoyl]- 3-phosphate dehydrogenase: shikimate ydiB ATP diphosphatase dehydrogenase II: beta-lyase MalY: malY arginine hydroxyl radical CO glyoxylate pyruvate epimerase UlaF: D-gluconate degradation I muramoylpentapeptide beta-N- synthase: otsA phosphatase Cca: cca AI-2 RS21865 AI-2 semialdehyde dehydrogenase: dehydrogenase: 2-iminobutanoate/ (2S)-2- ilvE -2-oxobutanoate pyruvate kinase I: sedoheptulose 2 dehydrogenase: lyase: prpB wcaJ MoaE: moaE menA menA malonyl-CoA dehydrogenase IMP α-D-glucosamine asd HisIE: C9E50_RS26705 decarboxylase: pyruvate kinase: pyk C9E50_RS25225 acetylglucosaminyltransferase: DacD: dacD a 5'-hydroxy- an [RNA]-3'- a (1->4)- isomerase: fabA a peptide acyltransferase: shikimate dehydrogenase: ydiB ydiB aspartate/ 2-iminopropanoate isopropylmalate cystathionine C9E50_RS12370 bisphosphate bypass phosphoenolpyruvate C9E50_RS12270 6-phosphate 2',3'-cyclic-nucleotide α maltohexaose a (3Z)-docos- AdhP: adhP ketoacyl-ACP UDP-2,3- shikimate C9E50_RS09585 adiA pyruvate kinase I: α-D-glucosamine 6-phosphate D-xylulose propanoyl-CoA murG α α a L-methionylaminoacyl- [+ 3 isozymes] ribonucleotide- uridine-3'- a proteinogenic canavaninosuccinate -D-glucan C9E50_RS01855 L-aspartate 4- asd tyrosine/aromatic deaminase: 3-isopropylmalate beta-lyase: metC L-ornithine synthase: ppsA α , -trehalose formate 2'-phosphodiesterase: a peptide formaldehyde 3-enoyl-[acp] ala a peptide synthase III: D-arabinofuranose diacylglucosamine a 1,2-diacyl- kinase 1-(5-phospho-β-D-ribosyl)- shikimate shikimate L-homoserine biosynthetic pyruvate D-sedoheptulose C9E50_RS12370 acyl-CoA pyruvate succinate 5-phosphate -D-glucopyranosyl- UMP a [SAMP] C- tRNA 3'-[RNA] phosphate amino acid trp 1-propanal semialdehyde shikimate aminotransferase: C9E50_RS24990 dehydratase: val glucosamine- ADP 6-phosphate molybdopterin DMK-12 DMKH2-10 cpdB C9E50_RS16715 5-phosphate diphosphatase: lpxH sn-glycerol AroL: aroL 5-[(5-phosphoribosylamino) L-aspartate 4- arginine 7-phosphate dehydrogenase: lipid II (meso UDP diphosphoundecaprenol terminal glycine L-alanyl-γ-D- predicted kinase C9E50_RS18535 leuC leuD 6-phosphate 3-deoxy-8- 3-phosphate bifunctional shikimate methylideneamino]imidazole- semialdehyde shikimate shikimate 2-oxobutanoate L-homocysteine 2-aminoprop-2-enoate decarboxylase: ethene pyruvate C9E50_RS22700 (S)-methylmalonyl- diaminopimelate containing) 3'-UMP glutamyl-L- D-ala ABC an acetoacetyl-[acp] AroL: aroL ornithine sedoheptulose- Secondary Metabolite Degradation deaminase: nagB pyruvate decarboxylation to acetyl CoA AI-2 AI-2 phosphooctulonate lipid X phosphatidate aspartate kinase/ kinase 4-carboxamide kinase kinase homoserine O- speA lys (2E,5Z)- CoA lysyl-D-alanine transporter of shikimate asp 2-isopropylmaleate decarboxylase 7-phosphate pyruvate synthase: kdsA cytidylyltransferase: homoserine AroK: aroK AroL: aroL AroL: aroL succinyltransferase: metA acetolactate 5-methyltetrahydropteroyltriglutamate- tetradecenoyl-CoA autoinducer 2 acetoacetyl- lipid-A- kinase 1-(5-phosphoribosyl) 4-hydroxy- bifunctional SpeF: speF kinase: pfkA dehydrogenase complex F6P a [pyruvate dehydrogenase pyruvate C9E50_RS14365 dehydrogenase shikimate shikimate bifunctional aspartate synthase: 3-isopropylmalate - homocysteine S- agmatine SAM lysine anhydromuropeptides recycling I superpathway of D-glucarate sulfoquinovose degradation I disaccharide AroK: aroK -5-((5- tetrahydrodipicolinate aspartate kinase/ D-sedoheptulose D-galactarate L-idonate 6 dehydrogenase 6 37 di-trans,octa-cis core a [ThiI sulfur- 6 all-trans- (1S,2R)-1- a [protein chain a [protein] N- an [amino group carrier 1498 [acp] I: thrA shikimate 3-phosphate cys ornithine dihydrolipoyllysine-residue superpathway of hexitol degradation (bacteria) ∆ 3 2 E2 protein] N -lipoyl-L-lysine N -dimethylallyladenosine an N -(1-hydroxy-2- 3-hydroxybenzoyl- a uracil a [protein]-L- KDO-8P kinase kinase kinase/homoserine ilvN ilvI dehydratase: methyltransferase: metE decarboxylase and D-galactarate degradation -cis-∆ -trans- enoyl-CoA 6-phosphofructokinase a sulfurated a uracil in tRNA 2-oxoglutarate 1-methyl-dAMP H O a uracil in DNA H O γ a primary alcohol an isocitrate (S)-NADPHX butan-1-ol (R)-glycerate tyr RS11180 tyr synthase: lpxB phosphatidate phosphoribosylamino) synthase: dapA homoserine O-succinyl-L-homoserine 1,7-bisphosphate degradation II degradation pyruvate(acetyl-transferring) -undecaprenyl oligosaccharide- carrier protein]- undecaprenyl 1,4-dihydroxy- C-(indol-3- 2 (R)-β-lysine elongation factor terminal-formyl- 2 protein]-C-terminal- - reductase: AroK: aroK AroK: aroK [+ 3 isozymes] leuC leuD 2-iminopropanoate decarboxylase: acetyltransferase: aceF GlcNAc-1,6- hydratase: class II fructose- pyruvate (R)-methylmalonyl- [sulfur carrier] in tRNA oxopropyl)-[protein]-L-lysine ser ATP CoA in 16S rRNA dehydrogenase IMP methionine cytidylyltransferase: bifunctional shikimate 3-phosphate methylideneamino) dehydrogenase dehydrogenase I: thrA methionine agmatinase: speB adenosylmethionine LdcC: ldcC α enoyl-CoA II: pfkB , homodimeric diphosphate diphosphate 2-naphthoate 34 L-methionine (L-glutamyl)-L-glutamate 16S rRNA alcohol zinc-binding peptide- fabG 3-phosphoshikimate 1- C9E50_RS04345 anhMurNAc- galactitol 1-(6-sulfo- -D-quinovosyl)glycerol bisphosphatase: CoA lipid A (E. coli S-sulfanyl- yl)glycerol EF-P]-L-lysine bifunctional bifunctional glycerate 3-deoxy-manno- lipid A disaccharide (E. coli) cdsA aspartate kinase/ imidazole-4- (2S,4S)-4- (S)-2-aceto-2- (2R,3S)-3- synthase: metH 2-iminobutanoate/ decarboxylase: speD D-glucarate galactarate L-idonate isomerase: fadB dehydrogenase type: aceE pyrimidine 5'- a (3R)-3- carboxyvinyltransferase: I: thrA shikimate 3- shikimate 3- [+ 2 isozymes] lysine sedoheptulose acetyl-CoA L-Ala-γ-D-Glu- glpX 6-phosphofructokinase: methylmalonyl- K-12 core type) L-cysteine 3-phosphate acetylglutamate (uracil(1498)-N(3))- dehydrogenase isocitrate ADP-dependent alcohol methionine 3-kinase: octulosonate-8- homoserine 3-phosphoshikimate 1- carboxamide isomerase: hydroxy-2,3,4,5- cystathionine gamma- hydroxybutanoate isopropylmalate 2-iminopropanoate galactarate fadB complex DNA oxidative protein deglycase uracil-DNA proofreading nucleotidase: hydroxybutanoyl- tetraacyldisaccharide a CDP- aroA bifunctional phosphate phosphate decarboxylase bisphosphate oxaloacetate DAP-D-Ala predicted pfkA pyruvate CoA tRNA (N6-isopentenyl 1,4-dihydroxy- FliI/YscN elongation peptide kinase: argB methyltransferase: AdhP: adhP dehydrogenase NAD(P)H-hydrate dehydrogenase: (S)-S-oxide glxK an acid RS15565 an dehydrogenase II: carboxyvinyltransferase: C9E50_RS09595 tetrahydrodipicolinate synthase: metB met deaminase: putrescine dAdoMet dehydratase: sulfoquinovosidase: yihQ (S)-3-hydroxy-(5Z) dihydrolipoyllysine- Kdo(2)-lipid A tRNA 4- demethylase HchA: hchA tryptophan glycosylase: thioesterase C9E50_RS24390 [acp] diacylglycerol 3-phosphoshikimate 1- L-aspartyl-4-phosphate ketol-acid multifunctional CadA: aldolase: fbaA PEP-driven glucarate dehydrogenase adenosine(37)-C2)- 2-naphthoate deformylase: 3 rsmE zinc-binding dehydratase/ C9E50_RS14610 reductase KdsC: kdsC 4'-kinase: lpxK C9E50_RS26705 5-enolpyruvoyl- aroA 4-hydroxy- aspartate kinase/ 3-phosphoshikimate 1- garD 5-dehydro- (3E,5Z)-tetradeca- -tetradecenoyl-CoA β-D-fructose 1,6-bisphosphate residue mutase: scpA thiouridine(8) AlkB: alkB protein deglycase synthase: family ATPase: factor P--(R) C9E50_RS06415 EntH: entH an [amino group carrier an N - kinase/ 3-phospho- beta-hydroxyacyl- reductoisomerase: C9E50_RS24990 C9E50_RS25570 N-acetylmuramoyl- galactarate phosphotransferase: 1498 NAD(P)H-hydrate [+ 3 isozymes] MsrA: msrA CDP-diacylglycerol-- shikimate 3-phosphate phosphoribulosylformimino- homoserine carboxyvinyltransferase: carboxyvinyltransferase: D-malate/3- transporter dehydratase: 5-dehydro-4- 6-sulfo-α-D-quinovose D-gluconate acetyltransferase: complex methylthiotransferase polyprenyltransferase: C9E50_RS04915 -beta-lysine C9E50_RS02745 protein]-C-terminal- methyluracil alcohol phosphatase: alcohol a protein-L- D-glycerate ACP dehydratase: lipid IV (E. coli) tetrahydrodipicolinate ilvC D-erythrose citrate (Si)-synthase: gltA L-alanine amidase: 3,5-dienoyl-CoA 3-hydroxyacyl-CoA succinyl-CoA lpxT synthase YajL: yajL trpB trpA epimerase: α-Kdo A glycerol-3-phosphate 3- 5-enolpyruvoyl- AICAR-phosphate dehydrogenase II: aroA aroA aspartate-semialdehyde isopropylmalate/ of galactitol: C9E50_RS05365 deoxy-D-glucarate dihydrolipoyllysine- MiaB: miaB menA ligase: epmA γ-(5-phospho-L- in 16S rRNA dehydrogenase: aceK dehydrogenase inosine C9E50_RS01830 L-homoserine chorismate reductase: dapB L-cystathionine pyruvate cadaverine DHAP dehydrogenase: aceF ThiI: thiI [+ 4 isozymes] a phosphorylated methionine- an acid RS02965 an acid oleate biosynthesis phosphatidyltransferase: shikimate 3-phosphate C9E50_RS26705 5-enolpyruvoyl- 5-enolpyruvoyl- dehydrogenase: (R)-2,3-dihydroxy- tartarate spermidine 4-phosphate malate dehydrogenase C9E50_RS05215 gatA gatB acyl-CoA pyruvate residue an apyrimidinic uracil glutamyl)-L-glutamate C9E50_RS14610 C9E50_RS25380 AdhP: adhP 3-deoxy-D-manno- synthase: (S)-2,3,4,5- galactarate glucarate fadB L-ascorbate dihydrolipoyl di-trans,octa-cis lipid A-core 1- formaldehyde succinate D-glyceraldehyde an N-terminal L- 3-hydroxybenzoate isocitrate (S)-S-oxide [+ 2 isozymes] 3-deoxy-manno- IV (anaerobic) pgsA shikimate 3- shikimate 3- C9E50_RS07715 3-methylpentanoate dehydrogenase: synthase: speE (quinone): mqo [+ 4 isozymes] thioesterase class II fructose- acetyltransferase: 6 dAMP site in DNA formate octulosonic acid chorismate imidazole aminopropylcadaverine PTS galactitol dehydratase: dehydratase: degradation II dehydrogenase a [pyruvate dehydrogenase 2-methylsulfanyl-N - -undecaprenyl diphosphate a [ThiI sulfur- a 4-thiouracil (R)-lactate a [protein]-L-lysine 3-phosphate trp H + [a protein chain methionyl-[protein] an aldehyde dehydrogenase NADPH 1-butanal octulosonate homoserine aroC tetrahydrodipicolinate NAD-dependent malic II: tesB 3-oxo-(5Z)- bisphosphate dehydrogenase: lpdA 37 an unsulfurated phosphate a (2E)-but- 1-(3-sn- phosphate phosphate aspartate-semialdehyde dihydroxy-acid dmlA 6-sulfo-D-quinovose a [pyruvate dehydrogenase E2 complex aceF6 5'-deoxyadenosine dimethylallyladenosine DMKH2-11 ADP transferase: synthase: glycerol bifunctional maltose synthase: speE β γ transporter garD gudD D-gluconate (bacterial, aerobic) E2 protein] N -S- met phosphate carrier protein]- in tRNA elongation factor cytidylyltransferase: a (3R)-3- phosphatidyl) kinase: thrB 2,3,4,5- chorismate chorismate acetyl-CoA enzyme: C9E50_RS13980 N-acetyl- -D- L-alanyl- -D- 2,5- acyl-CoA tetradecenoyl-CoA aldolase: fbaA 6 [sulfur carrier] an acid RS02970 an acid 2-enoyl-[acp] chorismate aroC phosphate L-homoserine dehydrogenase: asd regulon transcriptional dehydratase: 3-isopropylmalate subunit IIC: sulfoquinovose isomerase: protein] N -dihydrolipoyl-L-lysinedihydrolipoyllysine-acetyldihydrolipoyl-L-lysine in tRNA L-cysteine EF-P]-N-(β-L- kdsB C9E50_RS00875 hydroxydodecanoyl-[acp] -sn-glycerol tetrahydropyridine- synthase: synthase: glucosamine-1,6- glutamyl-meso-2,6- dioxopentanoate gluconokinase: thioesterase: acetyl-CoA C- L-ascorbate L-malate beta-hydroxyacyl- O-phospho- synthase: repressor/cystathionine ilvD dehydrogenase: spermidine aminopropylcadaverine C9E50_RS01730 5-dehydro-4- C9E50_RS27050 residue lysyl)-L-lysine 34 enoyl-ACP α-Kdo-(2->6)- gln 2,6-dicarboxylate N- malate synthase A: aceB anhydro-N-acetyl- diaminopimeloyl- triose-phosphate CMP-Kdo ACP dehydratase: 3-phosphate L-homoserine chorismate hisF hisH aroC aroC L-aspartate 4-semialdehyde beta-lyase MalY: malY (S)-3-methyl-2- leuB superpathway of L-aspartate (S)-malate citrate deoxy-D-glucarate gntK C9E50_RS01820 acyltransferase acetyltransferase: degradation II reductase lipid IV (E. coli) phosphatidylglycerophosphatase bifunctional anthranilate succinyltransferase: homoserine O- homoserine β-D-muramate D-alanine galactitol 1- FadI: fadI isomerase: tpiA A C9E50_RS01830 oxopentanoate (2S)-2-isopropyl- and L-asparagine biosynthesis 2-dehydro-3- 6-deoxy-6-sulfo-D-fructose D-gluconate (3E,5Z)- D-glyceraldehyde 3-phosphate DHAP aceF an anion RS19125 an anion FabI: fabI threonine synthase dapD succinyltransferase: kinase: thrB chorismate chorismate bifunctional aspartate cystathionine beta-N- phosphate L-dehydro- [2/3-O-acetyl-α-L-fucosyl]- 10 all-trans- 2251 a phosphorylated [+ 2 isozymes] C: yfhb chorismate mutase/ D-erythro-1- muramoyltetrapeptide tetradecadienoate acetyl-CoA C- (S)-malate β an L-methionyl- an N - a 1-acyl-2-lyso- crotonobetainyl- a nucleoside + a UDP-sugar guanosine a dipeptide with a synthase: anthranilate beta-lyase: metC branched-chain- 3-oxosuccinate aconitate hydratase deoxyglucarate 6-phosphate GDP- -L-fucose β L-carnitine 1,4-dihydroxy- an alkylated DNA FMN NAD(P)H H RNA a [protein]-L-tyrosine a protein with (S)-NADHX γ-L-glutamyl- roseoflavin cellulose [+ 2 isozymes] prephenate component AICAR N-succinyl- metA kinase/homoserine acetylhexosaminidase: carboxypeptidase: ldcA galactitol-1- 2-oxoglutarate type I ascorbate NAD-dependent (1->3)- -D-glucopyranosyl- Met formyltetrahydrofolate phosphatidylethanolamine DL-allothreonine CoA tridecaprenyl in 23S rRNA C-terminal L-proline isocitrate gly a butanoyl-[acp] a (2E)-dodec-2-enoyl-[acp] (imidazol-4- bifunctional bifunctional amino-acid AcnA: acnA aldolase: garL acyltransferase [initiator tRNA ] triphosphate a disulfide bond dITP an L-1- thrC I: trpE synthase 2-amino-6- dehydrogenase I: thrA glu nagZ γ phosphate 5- sulfofructose kinase: yihV malic enzyme: diphosphoundecaprenol diphosphate 2-naphthoate nucleoside triphosphate 23S rRNA tyrosine-protein dehydrogenase bifunctional D-alanine bifunctional dehydrogenase: yl)-glycerol cys O-phospho- chorismate mutase/ chorismate mutase/ L-alanyl- -D- D-sorbitol FadA: fadA glyceraldehyde- bifunctional UDP- bifunctional cellulase: KDO transferase: phosphatidyl- component ketopimelate transaminase: bifunctional aconitate dehydrogenase: C9E50_RS13980 pyrophosphohydrolase: (guanosine(2251) kinase Wzc: wzc protein-disulfide ADP-dependent XTP/dITP riboflavin beta- bifunctional 3- tyrA 3-phosphate O-succinyl-L- L-homoserine prephenate prephenate bifunctional aspartate L-homocysteine 2-aminoprop-2-enoate fumarate 1,6-anhydro-N- glutamyl-meso- 6-phosphate tartronate semialdehyde (3Z)-dodec- 3-phosphate colanic acid multifunctional acyl- L-carnitine DNA-3- NADPH- sugar hydrolase/ Xaa-Pro isocitrate bcsZ an anion RS19650 an anion C9E50_RS00875 sn-glycerol thr I: trpE N-succinyldiaminopimelate ilvE hydratase 2/2- β gatD acetyl-CoA pyruvate mazG ribonuclease PH: -2'-O)- tyrosine- reductase DsbD: NAD(P)H-hydrate diphosphatase: kinase/FAD hydroxydecanoyl- bifunctional homoserine kinase/homoserine 4-methyl-2- fumarate hydratase acetyl- -muramate diaminopimelate sorbitol-6- 6-deoxy-6-sulfo-D-fructose 1-phosphate dehydrogenase: methionyl-tRNA serine 1,4-dihydroxy- dehydrogenase glutathione ketoacyl- cyclopropane fatty acid bifunctional anthranilate aminotransferase: threonine dehydrogenase: dehydrogenase: aspartate/ methylisocitrate 2-hydroxy-3- L-galactonate 3-enoyl-CoA dehydroascorbate biosynthesis CoA thioesterase CoA- methyladenine dependent FMN 5'-nucleotidase: C9E50_RS00825 methyltransferase protein kinase: C9E50_RS25540 dipeptidase: dehydratase/ C9E50_RS04400 synthetase: ACP dehydratase/ histidinol- dehydrogenase II: oxopentanoate FumD: fumD anhydro-N- keto-D-tagatose phosphate gap formyltransferase: hydroxymethyltransferase: 2-naphthoate nucleoside a protein with kinase/ synthase: a cellodextrin ACP (CFA) biosynthesis threonine chorismate C9E50_RS02440 synthase: tyrA tyrA 5-methyltetrahydropteroyltriglutamate- ile tyrosine/aromatic aspartate dehydratase: acnB D-mannitol oxopropionate degradation ∆3,∆2- (bicyclic form) glycosyltransferase I/protease I/ transferase: glycosylase reductase: ssuE C9E50_RS21070 RlmB: rlmB C9E50_RS17890 pepQ NAD(P)H-hydrate [+ 2 isozymes] ribF trans-2- bifunctional anthranilate anthranilate phosphatase/ C9E50_RS26705 methionine L-isoleucine [+ 5 isozymes] acetylmuramic 6-phosphate dehydrogenase: C9E50_RS02740 C9E50_RS06570 polyprenyltransferase: triphosphate 2-O- reduced L- phosphatase: gshB Mg 2+ Mg 2+ synthase ammonia- mutase/ N-succinyl- cystathionine thrC bifunctional bifunctional - homocysteine S- branched-chain- aminotransferase: ammonia- 1-phosphate reductase: glxR sulfofructosephosphate aldehydo-L- enoyl-CoA WcaE: wcaE lysophospholipase caiB 2: alkA NAD(P)H-flavin a [protein]-L- epimerase: roseoflavin RS23980 α α decenoyl-ACP a [phospholipid] cis synthase glutamate imidazoleglycerol- synthase: metH biosynthesis III superpathway of glycolysis and the Entner-Doudoroff pathway acid kinase: srlD 13-DPG menA pyrophosphatase methylguanosine 2251 cysteine residues aceK dIMP Co 2+ Co 2+ II: fabF -Kdo-(2->4)- -Kdo- lyase, prephenate bifunctional anthranilate L,L-2,6- gamma- chorismate chorismate methyltransferase: metE 2-iminopropanoate amino-acid C9E50_RS18535 lyase: aspA Aromatic Compound Biosynthesis fumarate cis-aconitate aldolase: C9E50_RS27045 galactonate isomerase: L1: tesA reductase: an α-D-aldose UMP a nucleoside tyrosine phosphate C9E50_RS25380 5'-phosphate (2->6)-lipid IV (E. coli) isomerase: fabA phosphatidylglycerol -olefinic fatty acid dehydratase: amidotransferase component phosphate thr L-homoserine transaminase: anmK keto-D-fructose 2-hydroxy-3- α-L-fucosyl-(1->4)-[2/3- an N-formyl- YhdE: yhdE RNA in 23S rRNA a proteinogenic an isocitrate A cyclopropane fatty biosynthetic: diaminopimelate synthase: metB methionine mannitol-1- fadJ a DNA containing C9E50_RS27240 diphosphate pro beta- biosynthesis I (plastidic) synthase glutamate mutase/ mutase/ N-acetyl-D- oxopropionate phosphoglycerate α a tetrahydrofolate acetaldehyde a nucleoside 5'- an alkylated 1-phosphate amino acid dehydrogenase norophthalmate lauroyl acyl phospholipid ilvA pheA TrpG/anthranilate dehydratase succinyl- 2-iminobutanoate/ ilvE glu D-glucopyranose 6-phosphate succinate dehydrogenase: aconitate hydratase D-tagatofuranose 6-phosphate 2,3-dioxo- conversion of succinate to propanoate O-acetyl- -L-fucosyl]-(1- L-methionyl- gly crotono-betaine L-carnitinyl-CoA an apurinic/ NADH ketoacyl- amidotransferase component prephenate prephenate synthase: metH enterobactin biosynthesis glyoxylate phosphate 5- 3-sulfolactaldehyde DHAP (2E)-dodec- kinase: oxalate GDP met sn-glycero-3- monophosphate nucleobase a (3Z)-dodec-3-enoyl-[acp] phosphoribosyltransferase HisB: hisB methylaspartate asp C9E50_RS19930 muramate 6- reductase: D-tagaturonate L-gulonate >3)-β-D-glucopyranosyl- [initiator tRNA ] a carboxylate DMKH2-13 hemin RS12220 hemin ACP acyltransferase: DHAP synthase: TrpG/anthranilate diaminopimelate dehydratase: dehydratase: homoserine O- 2-iminopropanoate gallate biosynthesis 4-hydroxyphenylpyruvate AcnA: acnA 6-phosphate dehydrogenase: 2-enoyl-CoA C9E50_RS04555 degradation II phosphoethanolamine apyrimidinic site bifunctional TrpD: trpD 3-(imidazol-4- mutase subunit S: sdhA sdhC phosphate C9E50_RS03545 diphosphoundecaprenol + synthase lpxL a [phospholipid]C9E50_RS12445 phosphoribosyltransferase desuccinylase: L-cystathionine pheA pheA met deaminase: leu biosynthesis bifunctional aconitate tagatose-6- mtlD sulfolactaldehyde FMNH NAD(P) beta-ketoacyl- NAD(P)H- threonine prephenate yl)-2-oxopropyl succinyltransferase: metA C9E50_RS19850 asparagine chorismate N-acetylmuramic fatty acid succinyl-CoA 2 I: fabB α-Kdo-(2->4)-α-Kdo-(2-> fatty acid containing N-(5-phosphoribosyl) TrpD: trpD dapE C9E50_RS24990 succinate dehydrogenase/ hydratase 2/2- phosphate (R)-glycerate 3-reductase: yihU 3-phospho-D-glycerate oxalate methylmalonyl- ACP synthase dependent ammonia- phosphate synthase B: 3-dehydroquinate glucose-6-phosphate acid 6- oxidation 6)-(lauroyl)-lipid IV (E. coli) cyclopropane -anthranilate prephenate prephenate [+ 2 isozymes] type I 3- isochorismate tyr glucose-6-phosphate fumarate reductase methylisocitrate kinase: pfkA CoA a 3-oxohexanoyl- A II: fabF glycerol-3- lyase/L- N-(5-phosphoribosyl) histidinol- L,L- cys pyruvate (2S, 3S)-3- phosphate F6P complex hemin RS01570 hemin bifunctional bifunctional bifunctional indole-3-glycerol- bifunctional O-succinyl-L-homoserine C9E50_RS20190 dehydrogenase: zwf iron-sulfur subunit: glycerate 2- 3-sulfopropanediol 2,3- 3-keto-L-gulonate mutase: scpA a [2-oxoglutarate- di-trans,octa-cis α-D-Kdo-(2->4) α ε a cis-delta21-39- (2S,3S)-2,3- a [ribosomal 6-O-trans- a (1->4)- [acp] lauroyl-Kdo(2) a (5Z)-3-oxo- phosphate serine -anthranilate phosphate diaminopimelate methylaspartate dehydroquinate synthase aromatic amino isomerase: dehydratase: acnB etherase: murQ D-tagatofuranose 4-deoxy-L-threo-hex- subunit alpha 2,3-bisphosphoglycerate- a sulfurated quinoxaline-2- 2-oxoglutarate 1-methyl-dATP isobutanal 1,4-dihydroxy- 3-(N-morpholino) adenosylcobinamide N ,N -diacetyl-lysyl- fumarate citrate S-(hydroxymethyl) a [protein]-L- D-alanyl-D-alanine chorismate chorismate mutase/ maltose regulon bifunctional bifunctional aspartate- C9E50_RS25445 diphosphoglycerate- dehydrogenase -undecaprenyl -α-D-Kdo-(2->6) aryl-carrier protein GGPP asp oxo-40-methyl- β dihydroxy-5- protein L3]- DHAP methoxy-mycolyl- 3',5'-ADP α-D-glucan -lipid IV(A) dehydrogenase: ammonia- phosphate synthase TrpC/ dehydratase: aroD EntC: entC acid transaminase: C9E50_RS26245 N-acetyl-D- 1,6-bisphosphate 6-phosphofructokinase kinase: garK 4-enopyranuronate autoinducer AI-2 degradation FadJ: fadJ independent oxalyl-CoA SAM carboxyl adenylate propanesulfonate D-alanyl-D-alanine glutathione -isoaspartate tetradec-5-enoyl-[acp] prephenate bifunctional indole-3-glycerol- transaminase: transcriptional chorismate chorismate mutase/ -ammonia class II fructose- dependent [sulfur carrier] 6 diphosphate 2-naphthoate bifunctional oxohexanedioate L-glutamine D-alanyl- 3-oxotehexanoyl- myristoyltransferase: gpsA mutase/ phosphoribosylanthranilate diaminopimelate superpathway of L-serine 3-dehydroshikimate isochorismate C9E50_RS25990 succinate isocitrate lyase: aceA D-threo-isocitrate glucosamine II: pfkB degradation phosphoglycerate E2 protein] N - -lipid A (E. coli) bifunctional S-(hydroxymethyl) C59:1-[acp]cyclopropane fatty protein-L- 50S ribosomal NAD(P)H- trehalose 6- 3'(2'),5'- alpha- lyase phosphate synthase TrpC/ hisC repressor/ mutase/ prephenate cystathionine gamma- enoyl-CoA phosphoglycerate D-alanine + + [acyl-carrier msbB (5Z)-3-oxo- sn-glycerol prephenate dehydrogenase: isomerase TrpF: trpCF epimerase: dapF ligase: asnA 6-phosphate bisphosphatase: 2-phospho-D-glycerate 4-deoxy-L-threo-hex- mutase: gpmM oxalyl-CoA octanoyl-L-lysine adenosylcobinamide aconitate hydratase glutathione acyl phospholipid isoaspartate O- protein L3 dependent phosphate bisphosphate amylase: Cu RS20675 Cu TdcB: tdcB phosphoribosylanthranilate cystathionine prephenate dehydrogenase: synthase: metB and glycine biosynthesis I synthase aspartate/ 6-phospho D-glucono-1,5-lactone NADP-dependent tagatose- class II fructose- 6-phosphofructokinase: AI-2 hydratase: mutase: gpmA (R)-methylmalonyl- DNA oxidative acetaldehyde FMNH2-dependent serine-type L-aspartate trehalose- dipeptidase: protein] tetradec-5- 3-phosphate dehydratase: tyrA 1-(2- L-histidinol N-acetylglucosamine- glpX 4-enopyranuronate 3-keto-L-gulonate decarboxylase: propanoyl-CoA Kdo(2)-lipid A acyl carrier 1,4-dihydroxy- kinase/ 2/2-methylisocitrate dehydrogenase: synthase: methyltransferase: 2-dehydro-3- N(5)-glutamine glycerol-3- nucleotidase amyA lauroyl-Kdo(2) (2Z)-2-aminobut- isomerase TrpF: trpCF meso- beta-lyase dehydratase: tyrA L-cysteine biosynthesis VII methyloxaloacetate asn MenF: menF tyrosine/aromatic isocitrate dehydrogenase: succinate bisphosphate bisphosphate pfkA autoinducer- fadB CoA lipoyl demethylase dehydrogenase alkanesulfonate D-Ala-D-Ala oxidase: phosphatase: ddpX reductase: fabG enoyl-[acyl- pheA carboxyphenylamino) phosphate ADP-forming 6-phosphate DHAP D-galactonate degradation 6-phosphate C9E50_RS07460 phosphotransferase: protein: acpP 2-naphthoate adenosylcobinamide- dehydratase: acnB C9E50_RS21685 C9E50_RS12445 βpcm deoxyglucarate methyltransferase: phosphate CysQ: cysQ a (1->4)- -lipid IV(A) glycerol-3- 2-enoate 1-(2- diaminopimelate MalY: malY pheA 3-(4- (from S-sulfo-L-cysteine) 3-phospho-D-glycerate aminotransferase: 6-phosphogluconolactonase: F6P C9E50_RS16020 aldolase: aldolase: fbaAβ-D-fructose 1,6- 2 kinase: lsrK 2-phospho-D-glycerate synthase: AlkB: alkB (acetylating): monooxygenase: carboxypeptidase nadB a protein L- - trehalose-otsB α a (3R)-3- carrier-protein] 3-(4-hydroxyphenyl) -1-deoxy-D-ribulose succinate--CoA ligase (4S)-4-hydroxy-5- (S)-3- polyprenyltransferase: phosphate [+ 2 isozymes] a cis-keto-C60- dehydrogenase: -D-glucan + + myristoyltransferase: phosphate 1-O- bifunctional L-cystathionine D-3-phosphoglycerate L-asparaginase 1: 3,5- isochorismate 3-(4- C9E50_RS18535 C9E50_RS19665 deacetylase: nagA gatY gatZ 3-keto-L- lpxT [+ 3 isozymes] C9E50_RS21710 ssuD aconitate hydratase isoaspartate aldolase: garL a [ribosomalprmB D-ala Cu RS21045 Cu hydroxyhexanoyl- reductase: fabG 3-phenyl-2- pyruvate 5-phosphate carboxyphenylamino) cystathionine 3-phenyl-2- hydroxyphenyl) subunit beta: sucC bisphosphate phosphooxypentane- hydroxydodecanoyl-CoA formyl-CoA lipA menA guanylyltransferase: DacD: dacD meroacyl-[acp] gpsA trans-methoxy- AMP msbB acyltransferase: histidinol- diaminopimelate dehydrogenase: C9E50_RS11900 didehydroshikimate hydroxyphenyl) 6-phosphofructokinase N-acetylglucosamine- 5-dehydro-4-deoxy- D-galactonate gulonate-6- AcnA: acnA S-formylglutathione α-methyl ester protein L3]- [acp] oxopropanoate bifunctional indole-3-glycerol- -1-deoxy-D-ribulose beta-lyase: oxopropanoate pyruvate ser enterobactin tagatose- triose- 2,3-dione phosphopyruvate cobU [+ 3 isozymes] sn-glycerol mono-mycolate α-D-Kdo-(2->4)-α-D- a (3R,5Z)-3-hydroxy- C9E50_RS26155 aromatic amino phosphatase/ decarboxylase: lysA C9E50_RS04620 pyruvate D-gluconate 6-phosphate class II fructose- II: pfkB 6-phosphate D-glucuronate fatty acid phosphate formyl-CoA-- a [2-oxoglutarate α-D-Kdo-(2->4)-α- a quinoxaline-2- formaldehyde succinate 2-iminosuccinate succinate D-threo-isocitrate tartronate N 5 -methyl- beta-hydroxyacyl- phosphate synthase TrpC/ 5-phosphate metC aromatic amino L-asparaginase biosynthesis fructoselysine bisphosphate phosphate (4S)-4-hydroxy-5- hydratase: an unsulfurated di-trans,octa-cis- dATP 3-(N-morpholino) adenosyl-cobinamide pyruvate 3-phosphate Kdo-(2->6)-lipid A (E. coli) tetradec-5-enoyl-[acp] aromatic amino acid transaminase: imidazoleglycerol- aromatic amino bifunctional maltose 3-phosphooxypyruvate 2-oxobutanoate bisphosphatase: glpX 6-phosphofructokinase: deacetylase: nagA superpathway of hexuronide and hexuronate degradation 5-dehydro- oxidation decarboxylase oxalate CoA- 5'-deoxyadenosine met dehydrogenase D-Kdo-(2->6)-lipid carboxyl-[aryl- isobutanoyl-CoA NADH H + sulfite semialdehyde L-glutamine a metal a metal ACP dehydratase: glycerol-3- 2-iminobutanoate phosphoribosylanthranilate bifunctional indole-3-glycerol- acid transaminase: serine 2: ansB bifunctional and psicoselysine aldolase: isomerase: phosphonooxypentane- C9E50_RS05410 [sulfur carrier] undecaprenyl phosphate AMP demethylmenaquinol-4 propanal phosphate α ε RS23140 acid transaminase: C9E50_RS25990 phosphate lys acid transaminase: regulon transcriptional phosphogluconate pfkA 4-deoxy-D- complex UlaD: ulaD transferase: D-malate degradation E2 protein] N 6 A 1-diphosphate carrier protein] N ,N -diacetyl- cation cation C9E50_RS01830 lipopolysaccharide (3R,5Z)-3- phosphate 1-O- isomerase TrpF: trpCF phosphate synthase TrpC/ C9E50_RS25990 acetyltransferase: 3-phosphoserine isochorismatase/ D-glucosamine degradation kbaY kbaZ tpiA 2,3-dione isomerase: lsrG D-ala C9E50_RS25990 aspartate/ dehydratase 2-aminoprop- C9E50_RS25990 repressor/cystathionine acetolactate asp gallate dehydratase: edd succinyl-CoA 2-oxoglutarate a β-D-glucuronoside glucuronate 2-dehydro-3-deoxy- 3-hydroxy-5- subunit alpha C9E50_RS07455 -lipoyl-L-lysine lysyl-D-alanine [+ 2 isozymes] heptosyltransferase hydroxy- acyltransferase 2-iminobutanoate/ phosphoribosylanthranilate L-homocysteine aspartate/ C9E50_RS11060 aminotransferase: serC aryl carrier 6-phosphate N 6 -(D-psicosyl) L-xylulose aspartate/ tyrosine/aromatic (1S,2R)-1-C-(indol-3- HisB: hisB 2-enoate aspartate/ beta-lyase MalY: malY synthase: β-D-fructose 1,6-bisphosphate isomerase: D-galactonate phosphooxypentane- FadB: fadB (R)-malate RfaC: rfaC tetradeca-5- PlsY: plsY 2-iminopropanoate isomerase TrpF: trpCF tyrosine/aromatic serine O- protein EntB: entB phosphoglucosamine -L-lysine D-glyceraldehyde phosphoenolpyruvate 5-phosphate a (2E)-hex- a 1-acyl-sn tyrosine/aromatic aminotransferase: yl)glycerol 3-phosphate tyrosine/aromatic ilvN ilvI KDGP DHAP kduI 2,4-dione formate multifunctional D-malate/3- a metal a metal enoyl-[acp] deaminase: (1S,2R)-1-C-(indol-3- 5-methyltetrahydropteroyltriglutamate- aminotransferase: cystathionine acetyltransferase: mutase: glmM 3-phosphate 3-oxododecanoyl-CoA L-ribulose-5- RS26855 2-enoyl-[acp] heptosyl-Kdo -lipid A histidinol O-phospho-L-serine [+ 3 isozymes] (2S,3S)-2,3-dihydroxy- class II fructose- fructoselysine 3- a 5-methylaminomethyl- ADP-L-glycero-β- α-Kdo-(2->4)- an [RNA]-3'- 37 RNase G an [RNA]-3'- a protein-L- 2 -glycerol 3- aminotransferase: C9E50_RS18535 aminotransferase: L-proline 3-hydroxy-5- isopropylmalate/tartarate D-cellobiose N-(4-oxoglutaryl)- adenine a dipetide with an N- cation cation dehydratase: fabZ C9E50_RS24990 yl)glycerol 3-phosphate - homocysteine S- methionine C9E50_RS18535 beta-lyase: metC cysE type I 3-deoxy-D-glycero- pyruvate geranyl 34 methyl red succinate formyl-CoA 2,3-dihydrobenzoate bisphosphate α phosphate 3- α isovalerate canavaninosuccinate A ammonium H O val L-tartrate enoyl-ACP phosphate C9E50_RS18535 tryptophan C9E50_RS18535 biosynthesis I (S)-2-aceto-2- [EntF L-seryl- -D-glucosamine epimerase: frlC acetyl-CoA C- dehydrogenase: dmlA selenophosphate 2-thiouridine D-manno-heptose -Kdo-(2->6)- 6'-phosphate L-cysteinylglycine a type IV prepilin 2 ribonucleoside- in tRNA degradation terminal L-aspartate thr ribonucleoside- a protein methionine- ADP-heptose--LPS histidinol synthase: KHG/KDPG aldolase: triose-phosphate 2-dehydro-3-deoxy- phosphonooxypentane- kinase: pyk ATP 1 a (2E,5Z)-tetradeca- 2-oxobutanoate tryptophan methyltransferase: metE 2-iminopropanoate phosphoserine 2,3-dihydro-2,3- aldolase: fbaA 1-phosphate glyceraldehyde- D-glucopyranuronate 2,5-hexodiulosonate phosphoenolpyruvate epimerase UlaE: diphosphate in tRNA lipid IV (E. coli) ammonium hydrogencarbonate 2',3'- tRNA(1)(Val) substrate mRNA multifunctional 3'-phosphate (R)-S-oxide reductase 1-acyl-sn-glycerol- tyr synthase: (from L-glutamate) hydroxybutanoate carrier protein] 6 D-galactonate 2,4-dione thiolase: lsrF acyltransferase pyruvate A RNA 3'- heptosyltransferase 2,5-dienoyl-[acp] uracil dehydrogenase: methionine metH tyr 2-aminoprop-2-enoate O-acetyl-L-serine thiosulfate phosphatase: C9E50_RS11460 isomerase: tpiA 2-oxoglutarate N -(D-fructosyl) 3-phosphate 2-dehydro- synthase: ppsA pyruvate kinase I: C9E50_RS25230 ribonuclease E: L-threonine 3- peptide- FabI: fabI 3-phosphate phe trpB trpA synthase: degradation phe L-homocysteine ketol-acid ammonia dihydroxybenzoate dehydrogenase E1 bifunctional UDP-N- 6-phosphate FadA: fadA cyclophosphateRNA 2',3'-cyclic (adenine(37)-N(6))- C9E50_RS16745 dehydrogenase: D-malate/3- terminal pitrilysin: methionine a metal a metal RfaF: rfaF acetolactate hisD synthase: 2-iminobutanoate/ glu C9E50_RS24315 holo-ACP ser -L-lysine dehydrogenase: 3-deoxy-D- DHAP C9E50_RS12370 L-ribulose 5- lipopolysaccharide 6-phospho-beta- deaminated FMN-dependent formyl-CoA-- RS00810 enoyl-ACP acyltransferase: ser trpB trpA I (reductive) reductoisomerase: assimilation cycle III dehydrogenase: dhbA component: sucA acetylglucosamine acetyl-CoA C- tRNA 2- acetate--CoA prepilin peptidase: argininosuccinate hydroxylamine phosphodiesterase: methyltransferase: dipeptidase C9E50_RS00945 isopropylmalate/ phosphate C9E50_RS05195 (R)-S-oxide cation cation synthase: metH 2-iminopropanoate synthase: D-glyceraldehyde 3-phosphate gap gluconate 5- phosphate heptosyltransferase glucosidase: glutathione NADH- oxalate CoA- ribonuclease G: a hexanoyl-[acp] (heptosyl) -Kdo -lipid A reductase C9E50_RS01855 ser uracil histidinal 5-methyltetrahydropteroyltriglutamate- cysteine glutathione glutamate 5- ilvC diphosphorylase/ selenouridine(34) carbamate kinase: ligase: acs C9E50_RS28015 lyase: argH reductase: hcp 6 C9E50_RS06440 PepE: pepE tartarate cyclase: rtcA 2 2 a 1,2-diacyl- ilvN ilvI indole indole deaminase: ser 2,3-dihydroxybenzoate C9E50_RS06505 enterobactin dehydrogenase acyltransferase pyruvate RfaC: rfaC C9E50_RS05735 amidase: azoreductase: transferase: an [RNA]-3'-thpR an N - C9E50_RS02940 L-threonine an [RNA]-3'- reductase FabI: fabI - homocysteine S- methionine synthase kinase: proB glucosamine-1- aldehydo-D- L-ribulose-5- synthase C9E50_RS20840 37 dehydrogenase: lipopolysaccharide sn-glycerol histidinol C9E50_RS24990 γ-L-glutamyl (R)-2,3-dihydroxy- ammonium glu [EntB aryl- non-ribosomal type I glyceraldehyde- 13-DPG aldehydo-D-glucuronate KduD: kduD FadI: fadI [+ 2 isozymes] C9E50_RS20405 C9E50_RS14350 C9E50_RS07455 prepilin peptidase: ribunucleoside- methyladenine an mRNA fragment dehydrogenase: ribonucleoside-2',3'- a peptide MsrB: msrB beta- [+ 3 isozymes] met synthase: metH holo-[acyl- 6 galacturonate phosphate 4- carbamate kinase: arcC val dmlA a [protein]-L- methyltransferase: metE 2-iminopropanoate B: cysM serine 3-methylpentanoate L-selenocysteine carrier protein] (2,3- 3-phosphate phosphate N- N -(6-phospho- D-glyceraldehyde MnmH: mnmH heptosyl- C9E50_RS02560 in tRNA yiaY cyclophosphate trp RS00190 trp glucosyltransferase: a (5Z)-tetradec-5-enoyl-[acp] 3-phosphate (S)-2-aceto-2- dehydrogenase: 5-phosphate carrier- peptide pyruvate formate C- epimerase: 2'-phosphate 1 a proteinogenic 2-hydroxy-3- methionine ketoacyl- superpathway of L-alanine biosynthesis tryptophan tryptophan pyruvate methionine hydroxymethyltransferase: biosynthesis I (bacteria) dihydroxybenzoyl) acetyltransferase D-fructosyl) phosphoglycerate glucuronate glucuronate 2-dehydro-3- 3-phosphate decanoyl-CoA citrate degradation Kdo -lipid IV isovaleryl-CoA diphosphate L-canavanine fumarate hydroxylamine asp C9E50_RS00885 5,6-dihydrouracil hisD dihydroxy-acid synthetase dehydrogenase: gap ADP 2 A AMP aminoacetone oxosuccinate ACP phosphatidate hydroxybutanoate synthase: synthase: 2-iminobutanoate/ glutamate-5- 4'-phosphopantetheinyl protein] TCA cycle TCA cycle I (prokaryotic) GlmU: glmU isomerase: isomerase: deoxy-D-gluconate acetyltransferase: araD D-glucopyranose N,N-dimethyl-1,4- amino acid glucosyl-(heptosyl) beta-ketoacyl- L-cysteine biosynthesis I synthase: metH a reduced C9E50_RS06570 dehydratase: glutamine adenylate EntF: entF -L-lysine kinase: acyl-CoA a 5-methylaminomethyl- (2E)-3,7- D-glucopyranose 2-oxoglutarate L-cysteinylglycine anthranilate formate succinyl-CoA synthase cytidylyltransferase: S-sulfo-L-cysteine transferase AcpT: acpT synthase: uxaC uxaC pflB 34 carbamoyl phosphate 6-phosphate phenylenediamine ketol-acid 3-methyl-2- trpB trpA imidazole- trpB trpA 2-iminopropanoate semialdehyde synthetase: sec synthase: entE 13-DPG N-acetyl-α-D- C9E50_RS04555 L-ribulose-5- 2-selenouridine dimethylocta- a cleaved type -Kdo -lipid A ACP synthase C9E50_RS14365 his glutaredoxin ilvD selenide ser a tRNA [+ 2 isozymes] acpS [+ 2 isozymes] dehydrogenase: an acetyl-holo [citrate a peptide trp RS03345 trp II: fabF 2 2 reductoisomerase: oxobutanoate met deaminase: dehydrogenase: gly C9E50_RS14690 glucosamine fructoselysine [+ 2 isozymes] phosphate 4- citrate in tRNA 2,6-diene-1-thiol IV prepilin lipopolysaccharide II: fabF lactate (S)-3-methyl-2- [+ 3 isozymes] acetyl-CoA 3-phospho- D-tagaturonate D-fructuronate C9E50_RS22700 lyase acyl-carrier protein] beta- phosphatidate ilvC branched-chain- alanine ser C9E50_RS24990 proA selenide, a holo-[EntB aryl- a holo-[EntF L- 1-phosphate 6-phosphate epimerase UlaF: core heptose(I) degradation oxopentanoate glutamate-- (2,3-dihydroxybenzoyl) (L-seryl)adenylate phosphoglycerate D-glycerate ketoacyl- a (7Z)-3-oxo- cytidylyltransferase: (R)-2,3-dihydroxy- amino-acid trp trp 3-ureidopropanoate superpathway of L-asparagine biosynthesis racemization water serine--tRNA carrier protein] seryl-carrier protein] deglycase: frlB tagaturonate fructuronate acyl-CoA C9E50_RS25225 kinase RfaP: rfaP imidazole-lactate L-glutamate L-glutamate-5- ammonia ligase: adenylate kinase: C9E50_RS04555 bifunctional UDP-N- 2,3- KDGP acetyl-CoA formate α a 5,6- ACP hexadec-7-enoyl-[acp] cdsA 3-methylpentanoate transaminase: serine acetyltransferase: pyruvate branched-chain- dikinase ligase: serS oxaloacetate 2,3-bisphosphoglycerate- reductase: reductase: dehydrogenase: D-xylulose citrate lyase acyl β -D-glucopyranosyl- N-acetyl-D-glucosaminyl-N- a cytosine 32 an [L-cysteine sn-glycero-3-phospho- RNase III mRNA UTP a cis-delta19- hydrogen a myo-inositol a [protein] (3R,5S)-3- Peptide RS11080 Peptide biosynthesis III semialdehyde C9E50_RS27105 acetylglucosamine GDP- -L-fucose glutathionylspermidine pimeloyl-CoA isethionate GDP-α-D- 20 (S)-5-hydroxyisourate A(H2) glucosyl-(heptosyl) - a CDP- C9E50_RS11060 amino-acid β-D-glucose diphosphoglycerate- C9E50_RS13760 C9E50_RS24660 C9E50_RS12270 carrier protein: citD diphosphoundecaprenol acetylmuramoyl-L-alanyl-D-glutamyl- in tRNA desulfurase]-S- N-(arachidonoyl) processing ala a PII protein 37-methoxy-38- dihydrouracil peroxide (L-serine/L- a protein ser hydroxy-1- synthase 2 (7Z)-3-oxo- dihydroxy-acid ilvE ala SelD: selD enterobactin enterobactin 3-phospho-D-glycerate diphosphorylase/ independent 5-phosphate UTP nucleoside triphosphate perosamine monophosphate Kdo -lipid A-phosphate diacylglycerol cys asp serine O- cys transaminase: 6-phosphate lys dependent KHG/KDPG acetaldehyde phosphate [+ 2 isozymes] 6-carboxy-L-lysyl-D-alanine sulfanyl-L-cysteine ethanolamine substrate methyl-C57:1-[acp]cyclopropane fatty in tRNA bifunctional threonine) pyrroline-5- I: fabB 2 hexadec-7- dehydratase: catabolic 2-oxoglutarate citrate (Si)-synthase: gltA glucosamine-1- phosphoglycerate (2E)-dec-2-enoyl-CoA pyrophosphatase tRNA metalloprotease: L-serine ilvE sec non-ribosomal non-ribosomal phosphoglycerate D-altronate D-mannonate hydroxyisourate phosphate carboxylate lipopolysaccharide CDP-diacylglycerol-- ilvD val imidazole-pyruvate alanine acetyltransferase: cysE gln selenophosphate an L-seryl-[tRNA ] 2,3-bisphosphoglycerate- 2,3-diphosphoglycerate- mutase: gpmM aldolase: dehydrogenase acetyltransferase: pta colanic acid YhdE: yhdE GDP-perosamine N- acyl phospholipid dihydrouridine(20/ catalase/ glucose-1- protein-serine/ ammonia-lyase: pyrroline-5- a 3-oxooctanoyl- enoyl-[acp] pyruvate NADP-specific peptide peptide malate dehydrogenase phosphate N- mutase: gpmA tRNA 2- bifunctional FMNH2-dependent hydrolase: hiuH C9E50_RS18630 Peptide RS14515 Peptide core β-alanine racemase independent dependent C9E50_RS11460 ∆ 2 (acetylating): phosphate a citryl-holo [citrate biosynthesis 8-amino-7- bifunctional acetyltransferase: synthase: 20a) synthase phosphatase/ threonine C9E50_RS05315 carboxylate [acp] reductase: fabG glycerol-3-phosphate 3- (S)-3-methyl-2- asparagine asparagine glutamate (S)-1-pyrroline- synthetase synthetase (quinone): mqo acetyltransferase trans- - muramoyltetrapeptide glycerophosphodiester ribonuclease III: glutathionylspermidine alkanesulfonate nucleoside triphosphate peroxidase [+ 3 isozymes] heptosyltransferase cysteine DadX: dadX O-acetyl-L-serine ile glutamate dipicolinate biosynthesis phosphoglycerate phosphoglycerate 2-phospho- altronate mannonate C9E50_RS21710 acetyltransferase: lyase acyl-carrier protein] glycosyltransferase thiocytidine(32) oxononanoate uridylyltransferase/ C9E50_RS09560 C9E50_RS12445 DusA: dusA (S)-2-oxo-4- inositol phosphatase: reductase: a (3R,7Z)-3-hydroxy- phosphatidyltransferase: oxopentanoate synthase B: synthase B: dehydrogenase: hydrogen sulfide 5-carboxylate EntF: entF EntF: entF NAD-dependent malic GlmU: glmU decenoyl-CoA carboxypeptidase: ldcA phosphodiesterase: ugpQ C9E50_RS06485 amidase/synthase: monooxygenase: pyrophosphohydrolase: GDP-4-acetamido- KatP: katP [+ 3 isozymes] valine--pyruvate desulfurase synthase large L-seryl-tRNA(Sec) mutase: gpmM mutase: gpmA D-glyceraldehyde C9E50_RS07825 synthetase synthase: bioF a cis-methoxy- 20 hydroxy-4-carboxy- proC 3-oxooctanoyl- RfaQ: rfaQ pgsA alanine C9E50_RS20190 alanine C9E50_RS11935 enzyme: C9E50_RS13980 D-glycerate dehydratase: dehydratase: pyruvate hydratase: WcaI: wcaI C9E50_RS04185 ssuD uridylyl-removing mazG 4-amino-4,6- a uracil in tRNA phosphatase: pphB a peptide pyruvate hexadec-7-enoyl-[acp] branched-chain- transaminase: CsdA: csdA C9E50_RS20190 pyrroline-5- subunit: gltB selenium [+ 2 isozymes] [+ 2 isozymes] UDP-N-acetyl- D-glucarate 3-phosphate citrate lyase acyl TtcA: ttcA C59-meroacyl-[acp] 5-ureidoimidazoline Hyp [acyl-carrier glucosyl-(heptosyl) - 1-(3-sn- transaminase: racemase: α phosphopyruvate C9E50_RS03700 uxuA fadJ acetaldehyde protein GlnD: glnD α C9E50_RS17780 [+ 3 isozymes] predicted 3 amino-acid aspartate--ammonia glutamate cysteine synthase B: cysM carboxylate transferase: asp 2-phospho-D-glycerate -D-glucosamine carrier protein: citD N-acetyl-D-glucosaminyl-N- RNase III UMP dideoxy- - protein] Kdo -lipid A-phosphate (3R,7Z)-3- phosphatidyl) avtA [+ 2 isozymes] C9E50_RS07425 his alr degradation II hydratase: α-L-fucosyl-(1->3)- 8-amino-7- A H O myo-inositol a [protein] Ser/Thr ABC 2 transaminase: synthase large reductase: a 2,3-dihydroxybenzoyl- enoyl-CoA [+ 2 isozymes] 32 an [L-cysteine anandamide an mRNA fragment D-mannose 2 reductase: hydroxy-hexadec- -sn-glycerol ligase: asnA cysteine synthase A: cysK glu C9E50_RS01095 a seryl-[EntF L- bifunctional aspartate (S)-malate citrate UDP-N-acetylglucosamine C9E50_RS05410 ethanolamine acetyl phosphate β acetylmuramoyl-L-alanyl-D- D-ala a 2-thiocytosine sn-glycerol 3-phosphate processing coenzyme A glycolaldehyde Peptide Peptide lipopolysaccharide ilvE asn D-ala subunit: gltB proC [EntB aryl- phosphopyruvate hydratase: -D-glucopyranosyl- GDP desulfurase]- glutathione spermidine oxononanoate sulfite transporter fabG 7-enoyl-[acp] seryl-carrier protein] kinase/homoserine 1-carboxyvinyltransferase: D-glucarate glutamyl-6-carboxy-L-lysine in tRNA product mRNA a uridylylated core heptose(II) 3-phosphate carrier protein] hydratase: phosphoenol fadB utilization ethanol oxaloacetate diphosphoundecaprenol L-cysteine of a peptide a (3R)-3- dehydratase: fabZ phosphatidylglycerophosphatase ala glu an L-selenocysteinyl- dehydrogenase I: thrA aconitate hydratase murA glucarate dehydrogenase ethanolamine PII protein kinase RfaY: rfaY ile asn cys pro C9E50_RS05410 α pyruvate salmochelin degradation (S)-3- hydroxyoctanoyl- C: yfhb [tRNA sec ] [+ 2 isozymes] AcnA: acnA UDP-N-acetyl- - dehydratase: 2-dehydro-3- EutG: eutG utilization glucosyl-(heptosyl) -Kdo a (2E,7Z)-hexadeca- enterobactin hydroxydecanoyl-CoA a vitamin RS23135 a vitamin [acp] 3 2 L-aspartyl-4-phosphate D-glucosamine- C9E50_RS05365 pyruvate deoxy-D-gluconate acetate kinase 2,7-dienoyl-[acp] [+ 2 isozymes] non-ribosomal phosphoenolpyruvate bifunctional aconitate iron(III)-[diglucosyl- iron(III)-[monoglucosyl- [+ 2 isozymes] beta-hydroxyacyl- -lipid A-bisphosphate an L-1- enolpyruvate phosphoenolpyruvate kinase: pyk (S)-3- EutP: eutP an apo-[LYS2 L- an sn-glycero-3- RNase E mRNA a 1-(1-alkenyl) a 3-(all-trans 746 966 RNase II a double 6-O-trans-keto- hydratase 2/2- glucarate 1 a ribonucleoside uridine stachyose a guanine sn-glycerol peptide enterobactin] complex enterobactin] complex cob(II)inamide coenzyme A 2-oxoglutarate N -methyladenine phospho-N-(acyl) processing -sn-glycero-3- a single -polyprenyl) sulfite GSSH degradation an acetyl ester a protein mycolyl-trehalose histidinol ACP dehydratase: lipopolysaccharide enoyl-ACP phosphatidyl- aspartate-semialdehyde pyruvate kinase: pyk fumarate hydratase methylisocitrate UDP-N- dehydratase: synthase: ppsA pyruvate kinase I: hydroxydecanoyl- ethanol [+ 3 isozymes] ATP 2-aminoadipyl- triphosphate in 23S rRNA in 16S rRNA 3-phosphate stranded DNA GTP synthetase phosphoenolpyruvate ethanolamine substrate phosphocholine stranded DNA benzene-1,2-diol bifunctional tRNA 16S rRNA substrate mRNA DNA gyrase 6-phosphate C9E50_RS01830 3-alpha- reductase sn-glycerol dehydrogenase: pyruvate kinase I: FumD: fumD dehydratase: acnB acetylenolpyruvoylglucosamine gudD C9E50_RS12370 CoA carrier-protein] bifunctional 3- L-glyceraldehyde D-alanyl-D-alanine- histidinol predicted Nucleoside and Nucleotide Biosynthesis EntF: entF synthase: ppsA 5-dehydro-4- acetate pseudouridine(32) (guanine(966)-N(2)) subunit B: trehalose- [+ 2 isozymes] galactosyltransferase: FabI: fabI C9E50_RS07715 C9E50_RS12370 [+ 5 isozymes] reductase: C9E50_RS26540 dehydrogenase: DNA oxidative demethylubiquinone 3- alpha- exoribonuclease II: 3-phosphate carboxypeptidase/ dehydrogenase: diguanylate ABC [+ 2 isozymes] deoxy-D-glucarate pyruvate KDGP iron(III)-[monoglucosyl-(2,3- curcumin degradation rhodanese: synthase/23S rRNA -methyltransferase: C9E50_RS00255 acetyl esterase: phosphatase: a vitamin a vitamin waaO fumarate cis-aconitate UDP-N-acetyl- iron(III)-[salmochelin fadB cob(I)yrinic acid a,c-diamide 4'-phosphopantetheinyl demethylase DNA primase: O-methyltransferase/2- galactosidase: C9E50_RS14770 reductase: endopeptidase hisD cyclase transporter a (2E)-oct- a (7Z)-hexadec-7-enoyl-[acp] aspartate-semialdehyde dihydroxybenzoylserine) glycerophosphodiester ribonuclease E: lysoplasmalogenase: C9E50_RS13690 pseudouridine(746) rsmD C9E50_RS21090 otsB galactosyl-glucosyl- superpathway of purine nucleotides de novo biosynthesis II pyruvate α-D-muramate S2] complex Detoxification transferase AcpT: acpT C9E50_RS22205 octaprenyl-6-hydroxy melA an N 2 - C9E50_RS04125 : AmpH: ampH trehalose- DgcN: dgcN of a vitamin 2-enoyl-[acp] superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis superpathway of pyrimidine superpathway of guanosine superpathway of superpathway of pyrimidine deoxyribonucleoside salvage adenine and guanine and an N-(2,3- dehydrogenase: asd 3-oxodecanoyl-CoA adenosyltransferase: cobO AlkB: alkB phosphodiesterase: ugpQ C9E50_RS16745 C9E50_RS01905 thiosulfate a nucleoside 5'- L-glyceraldehyde (heptosyl) -Kdo - ] complex [+ 2 isozymes] [+ 2 isozymes] synthase RluA: rluA 966 C9E50_RS27770 his [+ 5 isozymes] 3 2 superpathway of (Kdo) -lipid A biosynthesis Cell Structure Biosynthesis ribonucleotides de novo biosynthesis succinate dehydrogenase: aconitate hydratase ribitol D-arabitol KHG/KDPG 3 curcumin phenol methylase: 746 methylguanine [+ 2 isozymes] trans-keto- beta-ketoacyl- 2 β nucleotides de novo biosynthesis I adenosine nucleotides adenosine salvage V guanosine salvage II dihydroxybenzoyl)- UDP-N- cob(I)yrinic acid a,c-diamide sulfurtransferase a pseudouridine monophosphate a negatively enoyl-ACP lipid A-bisphosphate Escherichia coli serotype O9a O-antigen biosynthesis lipid IV biosynthesis (P. putida) Escherichia coli serotype O86 O-antigen biosynthesis -D-galactosaminyl-(1->3)-N-acetyl- Kdo transfer to lipid C9E50_RS19930 degradation degradation aldolase: NADPH-dependent C9E50_RS08145 3-phosphate mono-mycolate c-di-GMP ACP synthase A PRPP de novo biosynthesis I 2'-deoxycytidine L-aspartate 4-semialdehyde AcnA: acnA 2,5- acetyl-CoA C- reactive oxygen species degradation adenosyltransferase: cobO a 2-methoxy- α-D- in 16S rRNA a peptide pro RS21480 pro reductase UDP-D- α-D-galactosamine biosynthesis IV IV (P. putida) seryl-[EntF L-seryl- acetylmuramate:L- phenylmercury a holo-[LYS2 L- RNase E GlpE: glpE in 23S rRNA raffinose supercoiled DNA a (3R)-3- A gln sdhA sdhC C9E50_RS11460 curcumin/ arsenate 8-oxo-(d)GTP detoxification I arsenate arginine dependent formaldehyde succinate an N- sn-glycero-3- ssDNA/pppN(pN) 6-(all-trans- galactopyranose acetate an alcohol II: fabF α a (3R)-3- α hydrogencarbonate gln carrier protein] bifunctional aconitate alanyl-gamma-D- dioxopentanoate acyltransferase acetate degradation 3',5'-ADP 2-aminoadipyl- sn-glycerol an mRNA fragment a fatty aldehyde FabI: fabI glucose:(glucosyl) hydroxytetradecanoyl- UDP-N-acetyl- UDP-N-acetyl- -D-glucosamine UDP-N-acetyl- -D-glucosamine UDP-N-acetyl-α-D-glucosamine lipid IV hydrogencarbonate IMP adenine guanosine 4-hydroxy- succinate dehydrogenase/ ribitol D-arabinitol iron(III)-[diglucosyl-(2,3- dihydrocurcumin detoxification detoxification acid resistance adenine acylethanolamine processing phosphocholine hybrid polyprenyl)phenol hydroxydecanoyl- CMP-Kdo A amidophosphoribosyltransferase: purF IMP cytidine hydratase 2/2- glutamyl- meso- FadA: fadA adenosylcobinamide 3-phosphate n -1 LPS α-1,3- a (9Z)-3-oxo- [acp] α-D-glucosamine UDP-N-acetylglucosamine-- UDP-N-acetyl- UDP-N-acetylglucosamine-- (P. putida) asp enterobactin D-glyceraldehyde dihydroxybenzoylserine) iron(III)-[salmochelin reductase: curA superoxide III (thioredoxin) carrier-protein] product mRNA D-ribulose 5-phosphate [acp] α UDP-N-acetylglucosamine-- deaminase: pyrimidine/purine tetrahydrodipicolinate fumarate reductase methylisocitrate diaminopimelate acetyl-CoA C- mercuriphenyl II (glutaredoxin) triphosphate glutathione thiosulfate an octanoyl-[acp] glucosyltransferase: octadec-9-enoyl-[acp] undecaprenyl-phosphate N- -D-glucosamine undecaprenyl-phosphate N- carbamoyl-phosphate IMP non-ribosomal 3-phosphate pyruvate ] complex S1] complex dihydrocurcumin pro RS17705 pro undecaprenyl-phosphate N- β nucleoside synthase: dapA iron-sulfur subunit: 2 superoxide acetate dGTP GTP arg waaO acyl-ACP--UDP-N- acetylglucosaminephosphotransferase: wecA acetylglucosaminephosphotransferase: wecA 5-phospho- - gly synthase: carB carbamoyl-phosphate cdd dCMP peptide dehydratase: acnB ligase: mpl D-ribulose D-xylulose acyltransferase arsenate arsenate (9Z)-3-oxo- arabinose-5- α α acetylglucosaminephosphotransferase: wecA 3-deoxy-D-manno- dehydrogenase: phosphorylase: C9E50_RS25445 beta- galactosyl-(glucosyl) N-acetyl- -D-glucosaminyldiphospho- acyl-ACP--UDP-N- N-acetyl- -D-glucosaminyldiphospho- α D-ribosylamine synthase: carB adenylosuccinate synthetase (2S,4S)-4-hydroxy-2,3,4,5- 2-oxoglutarate NADPH-dependent FadI: fadI dismutase [Fe]: sodB arsenate reductase arginine octadec-9- acetylglucosamine O- phosphate N-acetyl- -D-glucosaminyldiphospho- octulosonic acid C9E50_RS24080 guaB (d)CMP kinase: ppnP guanine UDP-N-acetyl- ketoacyl- ditrans,octacis-undecaprenol acetylglucosamine O- ditrans,octacis-undecaprenol C9E50_RS24080 synthase: purA 2'-deoxyuridine EntF: entF tetrahydrodipicolinate succinate D-threo-isocitrate ribulokinase: xylulokinase: dihydrocurcumin [+ 2 isozymes] (glutaredoxin): arsC decarboxylase: adiA an 6-sulfo-α- 3-(all-trans- 3-(all-trans a (1->4)- an N-terminal L- 745 a HypE hydrogenase 6-O-cis-methoxy- -(heptosyl) -Kdo - acyltransferase: lpxA ditrans,octacis-undecaprenol transferase: α RNase R degradation a guanine D-erythro-7,8- cis-vaccenyl a nucleoside 2+ 2+ 2 3 2 enoyl-[acp] isomerase acyltransferase: lpxA phosphoribosylamine- C9E50_RS18625 purine-nucleoside -D-muramoyl- octanoyl-CoA 8-oxo-dGTP 8-oxo-GTP cob(II)alamin coenzyme A an apo-[aryl- 2-methylbutanoate hypoglycin A glutathione nonaprenyl) -decaprenyl) α alanyl-[S18 protein chitin enterobactin mycolyl-trehalose a protein Zn RS01900 Zn ACP lipid A-bisphosphate N-acetyl-alpha-D- C9E50_RS00875 [+ 2 isozymes] NADP-dependent γ araB xylB iron(III)-[salmochelin reductase: curA arsenate reductase arsenite biosynthetic arginine ATP substrate RNA D-quinovosyl -D-glucan in 23S rRNA mutated tRNA dihydroneopterin acetate maturation protein- triphosphate reductase: fabG GutQ: gutQ N-acetyl-alpha-D- -glycine ligase: purD asp XMP thymidine kinase: dCDP phosphorylase: xanthine L-alanyl- -D- hydrogen peroxide carrier protein] benzene-1,2-diol benzene-1,2-diol of 30S ribosome] 23S rRNA bifunctional 6-phosphate synthase lipopolysaccharide UDP-3-O-[(3R)-3- glucosaminyl-diphospho- carbamoyl phosphate isocitrate dehydrogenase: D-ribulose D-xylulose SX] complex (glutaredoxin): arsC acetate benzene Hg 2+ decarboxylase: speA diacylglycerol bifunctional 3- bifunctional 3- ribosomal- enterochelin S-carboxamidehydrogenase serine UDP-3-O-[(3R)-3- glucosaminyl-diphospho- carbamoyl phosphate asp adenylo-succinate phosphoribosyltransferase: ADP-forming glutamyl-meso-2,6- tetrahydrocurcumin acyl-CoA 8-oxo-dGTP agmatine trehalose- nucleoside II: fabF glucosyltransferase: a (3R,9Z)-3-hydroxy- hydroxymyristoyl]-N- arabinose-5- α-D-mannosyl-(1->3)-N-acetyl- ditrans, octacis- α-Kdo-(2->6) C9E50_RS15380 deoD enterobactin C9E50_RS16020 5-phosphate 5-phosphate arsenite demethylubiquinone 3- demethylubiquinone 3- maltodextrin protein-alanine N- beta-N- (guanine(745)-N(1)) exoribonuclease II: esterase: dihydroneopterin maturation endoprotease polymyxin resistance hydroxydecanoyl]- ditrans, octacis- glutamine- nucleoside- adenosine C9E50_RS22615 dipicolinate succinate--CoA ligase diaminopimelate dehydrogenase: diphosphatase acetate- phosphatase: triphosphatase C9E50_RS00905 octadec-9-enoyl-[acp] acetyl-α-D-glucosamine phosphate α-D-glucosaminyl-diphospho- undecaprenol 4-epimerase: -lipid IV GAR thymidine catalase HPII: katE glutathione 4'-phosphopantetheinyl gamma- ribonuclease R: O-methyltransferase/2- O-methyltransferase/2- glucosidase: acetyltransferase: acetylhexosaminidase: -methyltransferase: C9E50_RS14770 C9E50_RS20610 aldolase/7,8- acetyl esterase: carbamoyl DegP: degP Zn 2+ RS03935 Zn 2+ beta- galactosyl-(glucosyl) UDP-3-O-acyl-N- N-acetyl-α-D- undecaprenol 4-epimerase: A aspartate hydrolyzing GMP adenylosuccinate dUMP diphosphate hypoxanthine subunit beta: sucC C9E50_RS22700 MutT: mutT cob(I)yrinic acid a,c-diamide -CoA C9E50_RS25320 sulfoquinovosidase: rlmA N-(2,3- dihydroneopterin C9E50_RS21090 otsB NudI: nudI isomerase ditrans,octacis-undecaprenol UDP-α-D- C9E50_RS09490 (P. putida) aspartate [+ 2 isozymes] peroxidase: transferase AcpT: acpT glutamyltransferase: octaprenyl-6-hydroxy octaprenyl-6-hydroxy malZ an N-terminal N-acetyl-rimI nagZ an N 1 - dehydratase trehalose- [+ 2 isozymes] ketoacyl- (3R,9Z)-3- glucosamine C9E50_RS09490 carbamoyltransferase: synthase: guaA lyase: purB kinase: adenosine phosphoribosyltransferase: acyl-CoA 8-oxo-GMP adenosyltransferase: cobO ligase: acs yihQ a nucleoside 5'- a nucleoside -(heptosyl) -Kdo - acetylglucosamine KdsD: kdsD α 3-deoxy-D-manno- C9E50_RS12195 arsenite [+ 2 isozymes] C9E50_RS02025 745 dihydroxybenzoyl) epimerase: folB ACP 3 3 2 hydroxy-octadec- glucuronate UDP-3-O-acyl-N- N-acetyl- -D-galactosaminyldiphospho- α phosphoribosylglycinamide carbamoyltransferase: pyrB thymidylate thymidine kinase: C9E50_RS06765 8-oxo-dGMP phenol methylase: phenol methylase: alpha-glucosidase: L-alanyl-[S18 protein methylguanine a HypE hydrogenaseHypE: hypE cis-methoxy- a peptide N-acetyl- -D-galactosaminyldiphospho- pyrB deaminase: C9E50_RS23610 dehydrogenase: hydroxyl radical 0 cob(I)yrinic acid a,c-diamide monophosphate D-threo-7,8- diphosphate lipid A-bisphosphate deacetylase: lpxC aldehydo-D-arabinose ditrans,octacis-undecaprenol octulosonic acid formyltransferase 2: purT Hg C9E50_RS08145 C9E50_RS08145 of 30S ribosome] in 23S rRNA -L-serine mono-mycolate synthase 9-enoyl-[acp] UDP-glucuronate acetylglucosamine ditrans,octacis-undecaprenol aspartate GMP synthase: C9E50_RS15380 Amino Acid Degradation C9E50_RS12270 O arsenite adenosyltransferase: cobO 2-methoxy- 6-(all-trans- C9E50_RS03755 N-acetyl-D- dihydroneopterin cis-vaccenyl maturation Zn 2+ RS19740 Zn 2+ UDP-3-O-(3- 5-phosphate transferase: aspartate AMP dCTP C9E50_RS12645 2 2-methylbutanoyl- a diribonucleotide a nucleoside 5'- 6-sulfo-α-D- chitin acetate I: fabB dehydratase: fabZ α-D-mannosyl-(1->3)-α-D-mannosyl- dehydrogenase: deacetylase: lpxC carbamoyltransferase thyA H O a holo-[aryl- diphosphate 6-(all-trans- decaprenyl)-2- glucosamine protein-S-cyanate hydroxymyristoyl) carbamoyltransferase GMP 2 3',5'-ADP CoA monophosphate a 1,2-diglyceride alcohol α arnA UDP-3-O-(3- C9E50_RS00875 FGAR regulatory subunit: pyrI succinyl-CoA 2-oxoglutarate (2E)-oct-2-enoyl-CoA carrier protein] AMP hypoglycin B L-cysteinylglycine quinovose a 3-oxodecanoyl- a (2E,9Z)-octadeca- -α-D-glucosamine (1->3)-N-acetyl- -D-glucosaminyl- α-Kdo-(2->4)-α- regulatory subunit: pyrI inosine adenosylcobalamin nonaprenyl)phenol methoxy-phenol a (1->4)- core oligosaccharide- β hydroxydecanoyl) α guanylate kinase: superpathway of L-arginine triphosphate D-glucopyranose [acp] 2,9-dienoyl-[acp] UDP-3-O-(3- diphospho-ditrans,octacis-undecaprenol UDP- -L-threo- N-acetyl- -D-galactosaminyl-(1->3)-N β-D-galactosyl-(1->3)-N-acetyl- Kdo-(2->6)-lipid phosphoribosylformylglycinamidine adenylate kinase: L-threonine degradation I L-cysteine degradation II L-tyrosine degradation I L-alanine L-glutamate L-tryptophan L-threonine degradation IV L-aspartate α-D-glucan lipid A (E. coli K-12 -α-D-glucosamine α C9E50_RS00800 adenine and and L-ornithine degradation fatty acid Zn 2+ RS14455 Zn 2+ hydroxymyristoyl) D-arabinofuranose pentapyranos- -acetyl- -D-galactosaminyldiphospho- α-D-galactosaminyl-diphospho- IV (P. putida) synthase: purL C9E50_RS21100 inosine/ degradation I degradation VI degradation II degradation I 3-oxodecanoyl- core type) (no GlcNAc) enoyl-ACP UDP-3-O-(3- A N-carbamoyl-L-aspartate superpathway of 5-aminoimidazole adenosine salvage II oxidation glucosamine N- 5-phosphate 4-ulose ditrans,octacis-undecaprenol N-carbamoyl-L-aspartate dTMP (to pyruvate) [acyl-carrier reductase hydroxymyristoyl) ditrans,octacis-undecaprenol ribonucleotide biosynthesis guanosine kinase: arg thr tyr (via pyruvate) complex lipopolysaccharide N- acyltransferase: α α UDP-4-amino-4- FGAM cys thr asp β-D-galactosyl-(1->3)-α- 18 527 α a (1->4)- FabI: fabI 3-deoxy-8- -D-mannosyl-(1->3)- -D-mannosyl- GDP ADP dTMP kinase: C9E50_RS21085 ala subunit alpha an N-terminal an L-phenylalanyl- AsbD acyl- an acyl-[acyl- O-succinyl-L- a guanosine raffinose a guanine a [protein]- - a negatively an organic protein] acetylglucosaminyltransferase: lpxD α deoxy-L-arabinose glucosamine N- 2-oxoglutarate threonine ammonia- serine dehydratase glu trp Alcohol Degradation coenzyme A methanethiol acetate butanoyl-CoA coenzyme A RNA reduced riboflavin L-fucosyl-(1->4)-[2/3-O- cyclic-AMP a protein Ap4A an oligopeptide α-D-glucan phosphooctulonate (1->3)- -D-mannosyl-(1->3)-N- dihydroorotase: pyrC C9E50_RS16680 adenosine catabolic aspartate/ FadJ: fadJ arginyl-[protein] [tRNA Phe ] carrier protein] homoserine in tRNA in 16S rRNA L-glutamate supercoiled DNA hydroperoxide predicted reductase: aminotransferase: acyltransferase: dihydroorotase: pyrC PRPP dehydrogenase E1 lyase, biosynthetic: ilvA aromatic amino carrier protein α DNA 1,4-alpha- C9E50_RS00910 an oleoyl-[acp] UDP-2-N,3-O-bis[(3R)- synthase: kdsA acetyl-α-D-glucosaminyl-diphospho- β-D-galactosyl-(1->3)-N-acetyl-α- UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) phosphoribosylformylglycinamidine IMP ribonucleoside subunit alpha tryptophanase: tyrosine/aromatic NADPH-dependent acetyl- -L-fucosyl]-(1-> tRNA 16S rRNA protein-glutamate O- 3',5'-cyclic-AMP multifunctional acyl- alkyl ABC fabG lpxD ribonucleoside- dTDP arginine acid transaminase: alanine methylaspartate low-specificity enoyl-CoA bis(5'-nucleosyl)- oligopeptidase glucan Zn 2+ Zn 2+ 3-hydroxytetradecanoyl]- ditrans,octacis-undecaprenol arnB D-galactosaminyl-(1->3)-N-acetyl- cyclo-ligase: purM amidophosphoribosyltransferase: purF hydrolase Macromolecule Modification component: sucA bifunctional threonine family protein: tnaA aminotransferase: superpathway of glycol assimilatory sulfite 3)-β-D-glucopyranosyl- (guanosine(18)-2'-O) alpha- (guanine(527)-N(7) methyltransferase topoisomerase III: phosphodiesterase: CoA thioesterase hydroperoxide transporter a (3R)-3- core oligosaccharide-lipid α UDP-4-amino- UDP-2-N-[(3R)-3- UDP-N-acetyl-α-D-glucosamine (S)-dihydroorotate nucleoside- ribonucleoside- diphosphate decarboxylase: C9E50_RS25990 racemase mutase subunit S: 2-aminoprop- L-threonine hydratase: metabolism and degradation ethanol degradation II ethanol degradation I glycerol degradation II cystathionine acetate CoA- colanic acid C9E50_RS11925 tetraphosphatase B: ptrB branching -D-glucosamine KDO-8P α-D-galactosaminyldiphospho- (S)-dihydroorotate nucleoside- β RihC: rihC ammonia-lyase/L- C9E50_RS03615 C9E50_RS18535 leucyl/phenylalanyl- 4'-phosphopantetheinyl phosphate CoA pyrophosphatase: reductase flavoprotein diphosphoundecaprenol -methyltransferase galactosidase: )-methyltransferase CheR: cheR cpdA I/protease I/ reductase: of Zn2+ hydroxydecanoyl- UDP A (E. coli K-12 core type) 4-deoxy-β-L- hydroxydodecanoyl]- diphosphate diphosphate reductase: 5-phospho- - adiA 2-aminoprop- DadX: dadX C9E50_RS19850 2-enoate aldolase: ltaE fadB glycerol degradation V transferase YdiF: biosynthesis (symmetrical): apaH enzyme: UDP-2,3- AIR serine ammonia- aspartate/ oxaloacetate tRNA--protein transferase AcpT: acpT gamma- C9E50_RS11650 toxin ChpB: chpB subunit: cysJ TrmH: trmH 7 RsmG: rsmG a [protein]-L- [+ 3 isozymes] ahpF ahpC ditrans,octacis-undecaprenol UDP-N-acetylglucosamine kinase: reductase: diphosphate D-ribosylamine adenine tRNA-uridine 2-thiolation L-ornithine 2-enoate acyltransferase C9E50_RS12275 a 2'-O- melA an N - lysophospholipase [acp] arabinopyranose 3-O-[(3R)-3- C9E50_RS08130 biosynthetic lyase TdcB: tdcB tyrosine/aromatic alanine [+ 2 isozymes] (S)-3- ethylene glycol ethanol glycerol transferase: synthase: metB acetyltransferase glutamate-O 5 a peptide glgB diacylglucosamine 3-deoxy- α α α 1-carboxyvinyltransferase: kinase: and selenation (bacteria) 5-(methoxycarbonylmethoxy) ethanol [+ 2 isozymes] PlsX: plsX NADPH-dependent β methylguanosine 18 methylguanine 527 a relaxed DNA L1: tesA an alcohol serine RS27905 serine bifunctional 3- -D-Man-(1->3)- -D-Man-(1->3)- -D-Man- bifunctional UDP- hydroxydecanoyl]- 5-(carboxyamino) C9E50_RS06765 C9E50_RS08130 nrdA phosphoribosylamine- lipoprotein posttranslational modification arginine (2Z)-2-aminobut-2-enoate aminotransferase: racemase: glycerol 2-O-acetyl- -D-galactosyl-WcaB: wcaB AMP ADP diphosphatase: lpxH manno- α α α murA C9E50_RS06765 adenine uridine biosynthesis (2S, 3S)-3- acetaldehyde hydroxyoctanoyl-CoA ethanolamine ethanolamine bifunctional L- C9E50_RS18745 an [RNA]-3'- a 5'-hydroxy- FMN reductase: ssuE α in tRNA α in 16S rRNA -methyl-ester a GlgE-glycogen hydroxydecanoyl- (1->2)- -D-Man-(1->2)- -D-Man-(1->3)- - 4-amino-4-deoxy- α-D-glucosamine imidazole PRPP nrdA -glycine ligase: purD decarboxylase: C9E50_RS18535 alr gly lactaldehyde bifunctional L- (1->3)- -L-fucosyl-(1->4)- -D- a peptide superpathway of phospholipid biosynthesis I (bacteria) octulosonate-8- α α α β α PRPP orotate class 1b phosphoribosyltransferase: methylaspartate fatty acid utilization ethanol utilization ethanol 1,2-propanediol 3',5'-ADP 4'-phosphopantetheine ribonucleoside- ribonucleotide- riboflavin α sucrose ACP dehydratase/ lipid X D-Man-(1->3)- -Man-(1->3)- -D-GlcNAc- L-arabinose UDP-2,3- -L-fucosyl-(1->2)- -D-galactosyl-(1->3) UDP-N-acetyl- -D- ribonucleotide orotate class 1b dTTP cys a [prolipoprotein]- speA ornithine 3-(4- D-ala reductase: fucO 1,2-propanediol 3',5'-ADP a holo-[AsbD acyl- met succinate acetyl-CoA butanoate [2/3-O-acetyl- -L-fucosyl]- galactopyranose phosphatase α ribonucleoside- C9E50_RS21125 SAM 2-iminopropanoate acetaldehyde oxidation dehydrogenase dehydrogenase dehydrogenase/ L-phenylalanyl-L- an acyl phosphate 3'-phosphate 3'-[RNA] β trans-2- superpathway of unsaturated diphospho-ditrans,octacis-undecaprenol formyltransferase/ diacylglucosamine -N-acetyl- -D-galactosaminyl-(1->3)-N glucosamine-enolpyruvate synthase: purK GTP GAR prephenate decarboxylase 2-iminopropanoate hydroxyphenyl) methylaspartate Phe carrier protein] acyl-carrier protein (1->3)- -D-glucopyranosyl- orotate ribonucleoside- diphosphate L-cysteine dehydrogenase complex EutG: eutG EutG: eutG glycerol dehydrogenase/ arginyl-[protein] a tRNA cystine RS26690 cystine decenoyl-ACP fatty acids biosynthesis (E. coli) DHAP lipid-A- KdsC: kdsC UDP-glucuronic diphosphatase: lpxH -acetyl-α-D-galactosaminyldiphospho- glu orotate cysteine SpeF: speF pyruvate ammonia-lyase: 2-iminobutanoate/ glycolaldehyde diphosphoundecaprenol UDP-N- phosphoribosyltransferase: diphosphate reductase: prolipoprotein (acetylating): subunit alpha [+ 2 isozymes] dehydrogenase: glycerol isomerase: fabA disaccharide acid oxidase ditrans,octacis-undecaprenol N5-CAIR phosphoribosyltransferase: phosphoribosylglycinamide phosphoribosylglycinamide AMP desulfurase agmatine ornithine 2-iminobutanoate 2-iminobutanoate/ C9E50_RS19865 2-iminopropanoate [+ 2 isozymes] NAD(P)H-dependent α-Kdo acetylenolpyruvoylglucosamine pyrE reductase: nrdF nrdE diacylglyceryl C9E50_RS21710 FadB: fadB acetaldehyde acetaldehyde gldA dehydrogenase: a (3R)-3-hydroxydecanoyl-[acp] synthase: lpxB ArnA: arnA lipid X (P. putida) aspartate/glutamate pyrE formyltransferase 2: purT formyltransferase: purN CsdA: csdA carboxy-S- decarboxylase: 2-iminopropanoate deaminase: [+ 3 isozymes] [α-D-Man-(1->3)-α-D-Man-(1->3)-α-D-Man- reductase: C9E50_RS26540 5-(carboxyamino) nrdF nrdE transferase: dihydroxyacetone gldA 4 glycerol-3-phosphate lipid A disaccharide racemase: ala adenosyl-L- 2-iminobutanoate/ deaminase: an osmoregulated 13-[O(2')-β-D-glucopyranosyl-β-D- an O - α-maltose 6'- 3 an N-acetyl-β- a 3,5,7,9,11,13,15- 2030 2552 a glucosylated UDP-4-deoxy-4- mesaconate an L-1-phosphatidyl- a [protein]- 37 an N -methyladenine adenine uridine β an organic (3E)-5-chloro-2- predicted dehydrogenase: gpsA 3-deoxy-manno- (1->2)-α-D-Man-(1->2)] -α-D-Man-(1->3)-α- lipid-A- α imidazole [+ 2 isozymes] C9E50_RS05160 C9E50_RS04345 pyruvate C9E50_RS24990 acetyl-CoA 3-oxooctanoyl-CoA acetaldehyde acetaldehyde dihydroxyacetone DMAPP an adenosine oxalate acetyl-CoA a peptide with a 4-nitrocatecholsulfate maltose GDP- -L-fucose an oligopeptide a (2E)-dec- (E. coli) n formamido-β-L- C9E50_RS05090 UDP-N-acetyl- -D-muramate dADP FGAR an [L-cysteine methionine 2-iminopropanoate C9E50_RS24990 periplasmic glucan sn-glycerol glucopyranosyloxy]docosanoate L-cysteine methylthymine phosphate in DNA D-hexosaminide hepta-oxo- in 23S rRNA in 23S rRNA hydroperoxide asp oxopent-3-enoate glycogenin ABC bifunctional 3- octulosonate D-Man-(1->3)-α-D-Man-(1->3)-α-D-GlcNAc- disaccharide α-D-galactosyl-(1->3)-[α-L-fucosyl- ribonucleotide orotidine 5'-phosphate purine deoxyribonucleosides salvage a [prolipoprotein]- agmatinase: homogentisate glycolate dehydrogenase: dehydrogenase in tRNA leader sequence GDP-L-fucose 1,4-alpha- cystine cystine 2-enoyl-[acp] arabinopyranose glutamate orotidine 5'-phosphate desulfurase]-S- synthase deaminase: pyruvate O(6'')-acetate in DNA hexadecanoyl-[PKS-acp] 23S rRNA 23S rRNA : maltose O- thioredoxin- aspartate/ 2-keto-4- transporter hydroxydecanoyl- sn-glycerol 3-phosphate tetraacyldisaccharide cytidylyltransferase: diphospho-ditrans,octacis-undecaprenol synthase: lpxB (1->2)]-β-D-galactosyl-(1->3)-N- mutase: purE S-1,2-diacyl-sn- speB pyruvate acetyl-CoA C- adhE (acetylating): aldo/keto synthase: oligopeptidase glucan racemase: murI UDP-N-acetylmuramate- dGDP nucleoside- phosphoribosylformylglycinamidine sulfanyl-L-cysteine CmoA: cmoA C9E50_RS24990 L-glutamate beta-N- (adenine(2030)-N(6) (uridine(2552)-2'-O) C9E50_RS13880 acetyltransferase: dependent thiol glutamate pentenoate of cystine ACP dehydratase/ 4'-kinase: lpxK kdsB undecaprenyl- lipid A acetyl-α-D-galactosaminyl-(1->3)-N- orotidine-5'-phosphate glyceryl-L-cysteine acyltransferase C9E50_RS21710 phosphatidylglycerol-- 6-phospho-alpha- DNA-3- CoA:oxalate reductase: C9E50_RS09535 A: prlC branching -L-alanine ligase: murC orotidine-5'-phosphate diphosphate synthase: purL degradation IX (via acetate DHAP methylated-DNA-- tRNA (adenosine(37)-N6) acetylhexosaminidase: signal )-methyltransferase -methyltransferase sulfatase: C9E50_RS21175 peroxidase: racemase: hydratase: enoyl-ACP bifunctional 3- trans-2-decenoyl- phosphate acetyl-α-D-galactosaminyldiphospho- CAIR decarboxylase: pyrF 2'-deoxyguanosine 2'-deoxyadenosine 2-oxobutanoate FadA: fadA membrane-oligosaccharide acetyl esterase: glucosidase: methyladenine CoA-transferase: C9E50_RS22025 α lipid IV (E. coli) CMP-Kdo disaccharide D-glt decarboxylase: pyrF nucleoside- kinase: a 5- S-adenosyl-S- (S)-citramalate 4-aminobutanoate) DHAP [protein]-cysteine S- -dimethylallyltransferase peptidase RlmJ: RlmE: rlmE C9E50_RS18895 6-O-acetyl- -D- GDP-L-fucose C9E50_RS06955 mhpD enzyme: reductase hydroxydecanoyl- ACP isomerase: fabA glycerol-3-phosphate glycerol-3-phosphate A 4-deoxy-4- lipoprotein acetyl-CoA glycerophosphotransferase: C9E50_RS00315 glycosylase I: tag C9E50_RS07470 nagZ 9-hydroxy-3,5,7,11,13,15- a 2'-O- C9E50_RS05090 [DNA] RS02320 [DNA] (P. putida) ditrans,octacis-undecaprenol α 34 acetyl-CoA C- C9E50_RS21090 5-chloro-4-hydroxy- glgB α-D-Man-(1->2)-α-D-Man-(1->2)-[α-D-Man- UDP-N-acetyl- -D-muramoyl-L-alanine UMP diphosphate C9E50_RS06765 FGAM hydroxyuridine carboxymethyl- 4-maleyl- acetate--CoA methyltransferase: MiaA: miaA C9E50_RS01630 2552 glucopyranosyl- synthase: fcl [+ 2 isozymes] a peptide FabI: fabI ACP dehydratase/ 1-O-acyltransferase: 1-O-acyltransferase: formamido- phosphoribosylaminoimidazolesuccinocarboxamide UMP a [TusA sulfur- signal peptidase: 2-ketobutyrate formate- glyoxylate opgB I: lepB hexaoxohexadecanoyl- an N 6 - methyluridine 4-nitrocatechol D-aspartate [+ 3 isozymes] (1->3)-α-D-Man-(1->3)-α-D-Man-(1->2)- tetraacyldisaccharide kinase: in tRNA L-homocysteine acetoacetate D-serine degradation glu acyltransferase ligase: acs C9E50_RS14490 (1->4)-D-glucose GDP-4-dehydro- 2-oxopentanoate a glycogen trans-2- C9E50_RS26155 C9E50_RS26155 3-deoxy-D-manno- L-arabinose synthase: purC (d)CMP kinase: C9E50_RS24105 lyase/pyruvate L-lysine degradation I an N-acetyl-β- [PKS-acp] methyladenine 2030 in 23S rRNA an alcohol α α α UDP-N-acetylmuramoyl- phosphoribosylformylglycinamidine carrier protein]-S- glutamate FadI: fadI D-glucopyranose α-D-rhamnose -D-Man-(1->2)] - -D-Man-(1->3)- -D- 4'-kinase: lpxK (d)CMP kinase: C9E50_RS06765 dATP maleylacetoacetate 6 37 D-glucopyranose an apurinic site an alcohol decenoyl-ACP a (2E)-dec-2-enoyl-[acp] glycerol-3-phosphate glycerol-3-phosphate octulosonic acid n transferase: peptidoglycan maturation (meso-diaminopimelate containing) C9E50_RS18625 dGMP dAMP sulfanyl-L-cysteine formate-lyase: tdcE an osmoregulated N -dimethylallyladenosine 3-methyladenine acetate oxalyl-CoA D-hexosamine in 23S rRNA a decanoyl-[acp] Man-(1->3)-α-D-Man-(1->3)-α-D-GlcNAc- lipid IV L-alanine--D- SAICAR C9E50_RS18625 cyclo-ligase: purM tRNA 5- decarboxylase: glyoxylate malate acetyl-CoA acetate sophorosyloxydocosanoate a [protein]-S- 6-phosphate within DNA predicted isomerase: fabA transferase: arnC A UMP kinase: pyrH an (S-diacyl-sn- a lipoprotein isomerase: maiA hexanoyl-CoA periplasmic glucan with a 1,2-diacyl-sn-glycerol in tRNA a leader sequence a peptide 1-O-acyltransferase 1-O-acyltransferase diphospho-ditrans,octacis-undecaprenol (P. putida) glutamate ligase: murD UMP kinase: pyrH dGTP methoxyuridine(34) propanoyl-CoA D-serine C9E50_RS13910 carboligase: synthase glycerol and glycerophosphodiester degradation a thymine in DNA ABC bifunctional 3- C9E50_RS00875 4-deoxy-4- lipid II (meso glyceryl)-L-cysteinyl- signal peptide putrescine lys 4-fumaryl- acetate pyruvate phosphoglycerol substituent methyl-L-cysteine gln gln beta- PlsY: plsY PlsY: plsY adenylosuccinate UDP AIR /uridine 5-oxyacetic D-serine ammonia- glutamate acyl-CoA gcl A: aceB transporter hydroxydecanoyl- formamido-α-L- α diaminopimelate containing) UDP [apolipoprotein] lysine decarboxylase a (3Z)-dec- D-ala meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- a [TusD sulfur- acid(34) synthase signal peptide phosphate acetoacetate dehydrogenase: of L-glutamine ketoacyl- ACP dehydratase/ α-Kdo-(2->6)- arabinopyranosyl peptidoglycan lyase: purB nucleoside-diphosphate apolipoprotein N- LdcC: ldcC lyase: dsdA decarboxylase: a glycerophosphodiester 3-enoyl-[acp] L-alanyl-D-glutamate carrier protein]-S- CmoB: cmoB peptidase glutamate- putrescine propionyltransferase: glycerol UDP-N-acetyl- decaprenyl-diphospho-N- 6 2498 32 an oxidized a [lipoyl-carrier ACP lipid IV (E. coli) α α kinase: C9E50_RS06765 2-aminoprop-2-enoate C9E50_RS01490 C9E50_RS22700 tartronate 13-sophorosyloxydocosanoate a [protein]- a DNA methyl a [protein]-N - 3-(all-trans-heptaprenyl) a [lipoyl-carrier γ a cytidine a uridine D-ribulose long chain norsolorinate trans-2-decenoyl- a 1-acyl-sn-glycerol 3-phosphate a 1-acyl-sn-glycerol 3-phosphate A 3-O-phospho- -D-Man-(1->2)- -D-Man- ditrans,octacis glycosyltransferase acyltransferase: lnt lysine decarboxylase (S)-malate α a peptidoglycan 2-oxoadipate (R)-lipoate -butyrobetaine cholate chenodeoxycholate 6 synthase D-alanine--D- AICAR gln sulfanyl-L-cysteine SppA: sppA putrescine ligase: aminotransferase: C9E50_RS07825 4-aminobutanoate semialdehyde -D-glucosamine acetylmuramoyl-pentapeptide 6',6''-diacetate L-cysteine phosphotriester monoubiquitinyl-L-lysine benzene-1,2-diol protein]-L-lysine in 23S rRNA in tRNA Ins(2)P hybrid- protein]-N -[(R) 5-phosphate anthrone repressor LexA asn RS14135 asn beta- ACP isomerase: fabA KDO transferase: (1->2)-α-D-Man-(1->3)-α-D-Man-(1->3) -undecaprenyl UDP-N-acetylmuramoyl- PbpC: pbpC nucleoside- an N-acyl-(S-diacyl- CadA: C9E50_RS25570 L-proline degradation acyl-CoA polyphosphate II: fabF alanine ligase: ddlA ribonucleoside- UTP dGDP dADP a 5-(carboxymethoxy) C9E50_RS14690 ygjG glycerophosphodiester glycerol kinase bifunctional 3- 23S rRNA bifunctional tRNA bifunctional glucose- 7-alpha- 7-alpha- cluster protein -dihydrolipoyl]- 1-deoxyxylulose- hydrogenase ketoacyl- C9E50_RS00875 -[α-D-Man-(1->2)-α-D-Man-(1->2)-α-D- phosphate 4-deoxy-4-formamido- L-alanyl-D-glutamate-- [+ 4 isozymes] bifunctional diphosphate kinase: adenine and pyrimidine sn-glyceryl)-L- propanoyl phosphate cadaverine L-phenylalanine dehydrogenase: 2-hydroxy-3- NADH D-alanine--D- diphosphate reductase: uridine 34 in tRNA a peptide phosphodiesterase: ugpQ GlpK: glpK undecaprenyldiphospho- demethylubiquinone 3- (cytidine(2498)-2'-O) pseudouridine(32) 1-phosphatase/ hydroxysteroid hydroxysteroid L-lysine 5-phosphate polyphosphate 3 maturation repressor beta- ACP a (3Z)-dec-3-enoyl-[acp] 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- α α Man-(1->3)-α-D-Man-(1->3)] -α-D-Man- L-arabinose- 2, 6-diaminopimelate a nascent peptidoglycan phosphoribosylaminoimidazolecarboxamide C9E50_RS06765 adenosine salvage III ribonucleosides cysteinyl-[lipoprotein] γ acetoacetate fumarate degradation II (anaerobic) C9E50_RS12270 oxopropionate methylated-DNA-- lysozyme: 2-oxoglutarate carnitine oxidoreductase: dihydrolipoyl -Kdo-(2->4)- -Kdo- n alanine ligase B: C9E50_RS08130 nrdA CTP synthase (glutamine nucleoside- nucleoside- 5 -glutamyl- pro muramoylpentapeptide beta-N- acetyl esterase: deubiquitinase: O-methyltransferase/2- lipoate--protein -methyltransferase synthase/23S rRNA dehydrogenase: dehydrogenase: synthase kinase 1: ppk1 protein synthase 3-phosphate 3-phosphate α α a [TusE sulfur tRNA cmo U34 4-aminobutanal cadaverine reductase: C9E50_RS08885 inositol phosphatase: dehydrogenase: LexA: lexA ketoacyl- (2->6)-lipid IV (E. coli) (1->3)- -D-Man-(1->3)- -D-GlcNAc- phosphoundecaprenol ligase: murE with (L-alanyl-γ-D-glutamyl- formyltransferase/IMP cyclohydrolase: purH hydrolyzing): pyrG salvage III diphosphate diphosphate L-putrescine acetate kinase: 2-iminopropanoate [protein]-cysteine S- dehydrogenase E1 monooxygenase: C9E50_RS18815 YajO: yajO predicted A C9E50_RS23765 gln class 1b ribonucleoside- methyltransferase: aminotransferase: ygjG trans-hex-2-enoyl-CoA acetylglucosaminyltransferase: C9E50_RS21090 elaD octaprenyl-6-hydroxy ligase LplA: lplA RlmM: rlmM pseudouridine(746) C9E50_RS17780 hdhA hdhA HypC: hypC I: fabB beta-ketoacyl-ACP acyltransferase: acyltransferase: 34 carrier protein]-S trifunctional C9E50_RS03545 [+ 11 isozymes] component: sucA yeaX yeaW a 2-O- α α lpdA 1-deoxy-D- ACP diphospho-ditrans,octacis-undecaprenol deformylase: meso-2,6-diaminopimeloyl-D- UTP cytidine kinase: kinase: a uridine in tRNA γ-glutamylputrescine C9E50_RS07830 phe sn-glycerol 3-phosphate murG methyltransferase: phenol methylase: synthase RluA: rluA 3 ,12 -dihydroxy-7- a reduced hybrid- a [lipoyl-carrier long chain cleaved ABC synthase I: fabB C9E50_RS01855 C9E50_RS01855 UDP-N-acetyl-α-D-muramoyl-L-alanyl- FAICAR diphosphate adenine -sulfanylcysteine cmoM transcriptional methylcytidine 2498 myo-inositol 7-oxolithocholate xylulose 5- norsolorinate his his synthase beta- C9E50_RS08015 D-alanyl-D-alanine alanyl-D-alanine) pentapeptide CTP pyrimidine-specific propionate kinase: tdcD aromatic amino 2-iminobutanoate/ fatty acid 2-hydroxy-3- C9E50_RS14490 a pseudouridine 32 oxo-5β-cholan-24-oate protein]-N 6 -[(R polyphosphate transporter 4-amino-4- γ reductase: nrdF nrdE pyrimidine/purine C9E50_RS06765 C9E50_RS06765 oxidase: 5-aminopentanal regulator/proline β β C9E50_RS08145 cluster protein repressor LexA I: fabB ketoacyl- beta-ketoacyl-ACP α -D-glutamyl-meso-2,6-diaminopimelate ribonucleoside a 5-(methoxycarbonylmethoxy) acid transaminase: 2-iminopropanoate oxidation oxopropionate anaerobic glycerol- 13-[O(2')- -D-glucopyranosyl- -D- N-acetyl-D- a N-acetylmuramoyl- a [ubiquitin] C- 2-methoxy-6-(all-trans a [lipoyl-carrier protein]- in 23S rRNA in tRNA )-lipoyl]-L-lysine phosphate of L-histidine deoxy- -L- bifunctional CTP synthase nucleoside 34 C9E50_RS14670 succinate tRNA 2- uridine in tRNA propanoate dehydrogenase/L- decaprenyl-pyrophosphoryl- acetate glucopyranosyloxy]docosanoate a [protein]-L-lysine CO glutaryl-CoA NADH 6 trimethylamine a 3- ACP synthase II: fabF kdo(2)-lipid IV(A) α α arabinopyranosyl serine-type serine-type hydrolase RihA: rihA dGTP dATP 4-(γ-L- C9E50_RS25990 deaminase: complex reductase: glxR 3-phosphate UDP glucosamine pentapeptide- terminal glycine -heptaprenyl)phenol 2 N -[(R)-lipoyl]-L-lysine 3-O-methylphospho- -D-Man-(1->2)- - UDP-N-acetylmuramoyl- phosphoribosylaminoimidazolecarboxamide (glutamine phosphorylase: ppnP thiouridine(34) 1-pyrroline aminobutyraldehyde glutamate gamma- (N-acetylglucosamine)-N- O(6'')-acetate a [protein]-S- semialdehyde D-ala D-ala oxododecanoyl- synthase palmitoleoyltransferase: α α ditrans,octacis α D-Ala-D-Ala D-Ala-D-Ala ribonucleoside glutamylamino) L-arginine degradation C9E50_RS24990 subunit alpha dehydrogenase: [DNA] diphosphoundecaprenol a (5Z)-3-oxododec-5-enoyl-[acp] D-Man-(1->2)- -D-Man-(1->3)- -D-Man- -D-Kdo-(2->4) tripeptide--D-alanyl-D- formyltransferase/IMP cyclohydrolase: purH hydrolyzing): pyrG purine-nucleoside synthase dehydrogenase: patD semialdehyde aspartate/ (R)-glycerate acetylmuramyl-(pentapeptide) methyl-L-cysteine D-serine RS25160 D-serine [acp] II: fabF lpxP α α α carboxypeptidase carboxypeptidase a mature peptidoglycan with dUDP hydrolase RihC: rihC periplasmic disulfide bond reduction butanal II (AST pathway) FadJ: fadJ glpC glpA lauroyl (1->3)-[ -D-Man-(1->2)- -D-Man-(1->2) -undecaprenyl - -D-Kdo-(2->6) alanine ligase: murF phosphorylase: deoD MnmA: mnmA dehydrogenase: tyrosine/aromatic pyruvate 3-oxododecanoyl- a (5Z)-3- DacD: dacD DacD: dacD (L-alanyl-γ-D-glutamyl-meso- cytosine γ-glutamyl-γ- 5-aminopentanoate gly gly 3-oxo-cis-∆ 5 - LpxL/LpxP -α-D-Man-(1->3)-α-D-Man-(1->3)] -α-D- phosphate -lipid A (E. coli) CTP nucleoside- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) adenosine a [DsbD protein] two reduced aminotransferase: enoyl-CoA glycerate glycerol-3-phosphate [acyl-carrier acyltransferase: n IMP adenine and putA 1 oxododec- α α α [+ 4 isozymes] [+ 4 isozymes] 2,6-diaminopimeloyl-D-alanyl- a reduced aminobutyraldehyde (S)-1-pyrroline- a [glycine-cleavage an N - p-nitrophenyl-α-D- α-L-fucosyl-(1->3)- 1402 RNase E dodecenoyl-[acp] a 1,2-diacyl-sn-glycerol 3-phosphate family Kdo(2)- Man-(1->3)- -D-Man-(1->3)- -D-GlcNAc- UDP-N-acetyl- -D-muramoyl-L- diphosphate kinase: cytosine 34 carrying a cysteine residues arg C9E50_RS18535 hydratase: 2-kinase: dehydrogenase: a sophorosyloxyfatty N-acetyl-4-O- a cytidine a [release factor]- a [phospholipid]- protein] lpxL D-alanine) pentapeptide nucleoside adenosine salvage I a 2-thiouridine dehydrogenase: puuC L-threonine 3-phenyl-2- complex H protein] 2-oxoglutarate ethyladenine isobutanoate glycerophosphoserine a 9S rRNA β-D-glucopyranosyl- Ins(1)P degradation [DNA] 3-methylgentisate L-dopa an unfolded 5-enoyl-[acp] reductase: fabG lipid IV(A) lauroyl/ diphospho-ditrans,octacis-undecaprenol lipid IV(A) 4- alanyl-γ-D-glutamyl-meso-2,6- C9E50_RS06765 CTP adenosine deaminase: codA thioredoxin disulfide bond in a protein aminobutyraldehyde arginine N- 5-carboxylate fadB garK C9E50_RS02140 a sulfurated [sulfur carrier] SAM galactopyranoside acid 6',6''-diacetate acetylneuraminate in 16S rRNA L-glutamine oleate a protein met phe RS20670 phe reductase: fabG ∆ 5 triphosphatase in tRNA 4-(γ-L- oxopropanoate 6 protein 3-oxo-cis- - phosphatidate amino-4-deoxy-L- diaminopimeloyl-D-alanyl-D-alanine a nascent peptidoglycan a nascent peptidoglycan dehydrogenase: patD degradation III (to succinyltransferase: N -octanoyl-L-lysine in DNA diphosphoundecaprenolcolanic acid 16S rRNA peptide chain bifunctional glucose- cyclopropane fatty substrate mRNA DNA polymerase ATP-dependent gentisate 1,2- a (3R)-3- palmitoleoyl γ NudI: nudI deaminase: uracil adenine salvage L-threonine (S)-3- 2-phospho- amino-acid N- 4,5-DOPA dodecenoyl- a (3R,5Z)-3-hydroxydodec- cytidylyltransferase: arabinosyltransferase: with (L-alanyl- -D-glutamyl- with D,D cross-links (meso- dUTP nucleoside tRNA uridine-5- glutamylamino) methylglyoxal) DHAP (cytidine(1402)-2'-O) release factor acyl phospholipid ribonuclease E: III subunit theta: hydroxydodecanoyl- acyltransferase: C9E50_RS12645 adenosine N 2 -succinyl-astA degradation II hydroxyhexanoyl-CoA D-glycerate alpha- sialate O- biosynthesis 1-phosphatase/ Clp endopeptidase acetyltransferase: dioxygenase: dioxygenase chaperonin [acp] 5-enoyl-[acp] C9E50_RS14365 arnT meso-2,6-diaminopimeloyl- diaminopimelate containing) IMP CDP triphosphatase carboxymethylaminomethyl(34) butanoate glutarate semialdehyde DNA oxidative acetate--CoA glycerophosphodiester acetyl esterase: ribonuclease E: -methyltransferase: N(5)-glutamine synthase: C9E50_RS16745 C9E50_RS11500 [acp] lpxL dUTP diphosphatase: pyrimidine/purine thr L-arginine L-serine degradation lipoyl galactosidase: melA acetylesterase: acetyltransferase inositol phosphatase: proteolytic C9E50_RS05210 gtdA extradiol: ygiD GroEL: groL reductase: 5 D-alanine) tetrapeptide dehydrogenase: NudI: nudI synthesis enzyme MnmG: mnmG 3-hydroxyhexanoyl- demethylase ligase: acs phosphodiesterase: ugpQ C9E50_RS21090 C9E50_RS16745 rsmI methyltransferase: C9E50_RS12445 (2E)-2-methyl- 3-hydroxy cis ∆ - phosphatidate C9E50_RS00840 inosine nucleoside L-threonine 3- L-glutamate-5- C9E50_RS23495 [2/3-O-acetyl-α-L-fucosyl]-WcaF: wcaF a 2'-O- C9E50_RS17780 [+ 9 isozymes] subunit ClpP: clpP glycerol RS26795 glycerol beta-hydroxyacyl- fabG 4'-α-L-Ara4N-α- guaB ribonucleoside- adenine tRNA uridine-5- gamma- N-succinylarginine phenylacetaldehyde thr CoA synthase: lipA AlkB: alkB prmC a [phospholipid]- a nucleoside 5'- N-acetyl-L- 4,6-dioxohept- dodecenoyl-[acp] cytidylyltransferase: cdsA [+ 2 isozymes] phosphorylase: ppnP semialdehyde β methylcytidine 1402 myo-inositol an mRNA fragment 4,5-seco-dopa a protein ACP dehydratase: α L,D- muramoyltetrapeptide L,D- diphosphate reductase: CDP glutamyl-gamma- dehydrogenase: dehydrogenase: (1->3)- -D-glucopyranosyl- a [release factor]-N 5 dihydrosterculate a peptide a (3R,5Z)-3- dehydratase: fabZ α-Kdo-(2->4)-α- Kdo-(2->4)- - a mature peptidoglycan carboxymethylaminomethyl(34) dihydrolase: astB ser L-threonine 3- monophosphate methionine 2-enedioate C9E50_RS01830 transpeptidase: ldtA carboxypeptidase: ldcA transpeptidase: ldtA C9E50_RS08130 nrdA dUMP pyrimidine/purine purine-nucleoside aminobutyrate C9E50_RS00945 trifunctional fadB D-galactopyranose a sophorosyloxyfatty diphosphoundecaprenol in 16S rRNA -methyl-L-glutamine hydroxydodec- a CDP-diacylglycerol Kdo-(2->6)-(lauroyl) Kdo-(2->6)-[P4'- with D,D cross-links (meso- ribonucleoside- synthesis GTPase MnmE: mnmE 2 dehydrogenase: a [glycine-cleavage isobutanoyl-CoA sn-glycerol 4-nitrophenol acetate a 5S rRNA an rRNA fragment [+ 2 isozymes] Kdo -(palmitoleoyl) ribonucleoside- nucleoside phosphorylase: deoD L-threonine glutarate N -succinyl- transcriptional L-serine an unsulfurated acetaldehyde an adenine in DNA succinate diphosphate ser acid O(6'')-acetate acetate N-acetylneuraminate predicted 5-enoyl-[acp] a (2E,5Z)-dodeca-3,5-dienoyl-[acp] -lipid IV (E. coli) 2 α-L-ara4N]-lipid A [+ 4 isozymes] [+ 3 isozymes] a mature peptidoglycan diaminopimelate containing) class 1b ribonucleoside- diphosphate adenine deaminase: adeD adenine a 5-carboxymethylaminomethyl- hydrolase: puuD C9E50_RS00945 5'-deoxyadenosine met complex H protein] N 6 AMP 3-phosphate A -lipid IV a nascent peptidoglycan with γ thymidylate phosphorylase: ppnP adenine L-ornithine regulator/proline ammonia-lyase: 3-oxohexanoyl-CoA Aldehyde Degradation ABC 3-hydroxy cis A with (L-alanyl- -D-glutamyl- XMP diphosphate diphosphate phosphoribosyltransferase: 34 dehydrogenase: [sulfur carrier] a (2E)-dodec- lauroyl-Kdo(2) γ synthase: thyA reductase: 2-thiouridine in tRNA L-threonine -[(R)-lipoyl]-L-lysine D-xylose D-xylose ∆ 5 CDP-diacylglycerol-- CDP-diacylglycerol--serine a nascent peptidoglycan (L-alanyl- -D-glutamyl-meso- a nascent peptidoglycan glutarate succinylornithine/ dehydrogenase/L- phenylacetate C9E50_RS05315 transporter 2-enoyl-[acp] -dodecenoyl- -lipid IV(A) lauroyl-Kdo(2) meso-2,6-diaminopimeloyl- reductase: nrdF nrdE reductase purine-nucleoside C9E50_RS21125 yiaY dehydrogenase: acetyl-CoA C- enoyl-ACP glycerol-3-phosphate 3- O-phosphatidyltransferase: with L,D cross links (meso- 2,6-diaminopimelate) tripeptide with (L-alanyl-γ-D-glutamyl- dTMP C9E50_RS08130 UDP adenine 5-aminomethyl- L-2-amino-3- hydroxylase: csiD acetylornithine glutamate gamma- [+ 3 isozymes] of D-xylose [acp] myristoyltransferase: -lipid IV(A) D-alanine) tetrapeptide glutamine- subunit phosphorylase: deoD 4-aminobutanoate 2-aminoprop- yiaY acyltransferase methylglyoxal degradation I enoyl-ACP reductase FabI: fabI dCDP nrdA hypoxanthine phosphoribosyltransferase: 2-thiouridine oxobutanoate L-lactaldehyde L-lactaldehyde 1 phosphatidyltransferase: pssA myristoyltransferase: diaminopimelate containing) meso-2,6-diaminopimeloyl- alpha: nrdA transaminase: astC semialdehyde L-2-amino-3- methylglyoxal an N - a Chi-site containing an α-D- a long-linear an [apo BCAA 1402 1835 38- (2Z)-2- dehydratase: msbB hydrolyzing asp dTMP kinase: 2 2-enoate a [pyruvate dehydrogenase E2 α a sophorosyloxyfatty N-acetyl-9-O- a cytidine a guanine a uridine reductase class 1b ribonucleoside- C9E50_RS21125 synthase: protein S-nitrosylation protein-disulfide 4-aminobutyrate- (S)-2-hydroxyglutarate N -succinyl- FadA: fadA degradation III degradation (aerobic) degradation 2-oxoglutarate -D-glucopyranose α melibionate dehydrogenase E2 protein] Ins(5)P β L(or D)-O- 4-methylgentisate hydroxyhexa- fabZ pgsA msbB glycine) tetrapeptide nucleoside- ribonucleoside- hypoxanthine dehydrogenase: oxobutanoate a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine methyladenine double stranded RecA galactoside -D-glucan acid O(6'')-acetate acetylneuraminate in 16S rRNA in 23S rRNA 40 in tRNA L-ornithine -alanine a protein ala D-xylose RS26210 D-xylose GMP C9E50_RS16680 diphosphate AMP methylglyoxal 6 phosphoserine FabI: fabI a (5Z)-dodec-5-enoyl-[acp] lauroyl-Kdo(2) diphosphate kinase: ribonucleoside- diphosphate xanthine mnmC and denitrosylation reductase DsbD: -2-oxoglutarate L-glutamine L-glutamate 5- putA acetyl-CoA C- (anaerobic) in DNA DNA with a blunt end N -dihydrolipoyl-L-lysine 16S rRNA 23S rRNA tRNA 2,5-dienoate a 3-sn-phosphatidyl-L-serine lauroyl-Kdo(2) a mature peptidoglycan with synthase: reductase: L-2-hydroxyglutarate bifunctional glucose- 4-aminobutyrate- gentisate 1,2- 2-keto-4- a (2E,5Z)-dodeca- -lipid IV(A) γ adenylosuccinate dTDP formate diphosphate reductase phosphoribosyltransferase: AMP a 5-aminomethyl-2- C9E50_RS25540 transaminase: degradation I semialdehyde L-histidine glycine C- acyltransferase lactoylglutathione methylglyoxal (S)-lactaldehyde dihydrolipoyl (cytosine(1402)-N(4) (guanine(1835)-N(2) pseudouridine(38- arginine N- phosphoserine alanine 1-(3-sn-phosphatidyl)- -lipid IV(A) a mature peptidoglycan (L-alanyl- -D-glutamyl-meso- guaA C9E50_RS06765 C9E50_RS08130 xanthine a [protein]- a [DsbD protein] (S)-lactaldehyde alpha- 4-alpha- sialate O- alpha- 1-phosphatase/ -2-oxoglutarate endopeptidase La: dioxygenase: pentenoate a dodecanoyl-[acp] 3,5-dienoyl-[acp] myristoyltransferase: C9E50_RS22615 34 an oxidized an intra- dehydrogenase: lhgO succinylglutamate- acetyltransferase: kbl FadI: fadI lyase: gloA methylglyoxal dehydrogenase: succinyltransferase: phosphatase: transaminase: beta-ketoacyl-ACP sn-glycerol 3-phosphate phosphatidylserine with L,D cross-links (meso- 2,6-diaminopimelate) tripeptide synthase: purA reductase: subunit phosphoribosyltransferase: thiouridine in tRNA with reduced L- gabT aminoacetone glu degradation IV (R)-S- lactaldehyde DNA oxidative galactosidase: glucanotransferase: acetyl esterase: galactosidase: )-methyltransferase )-methyltransferase inositol phosphatase: 40) synthase C9E50_RS21275 gtdA msbB myristoyltransferase: a mature peptidoglycan dCTP nucleoside- nrdA L-cysteine thioredoxin protein disulfide semialdehyde 2-iminopropanoate reductase exodeoxyribonuclease acetylesterase: lpdA astA transaminase: C9E50_RS24315 C9E50_RS07425 hydratase: lactose RS21760 lactose enoyl-ACP synthase I: fabB nrdF nrdE alpha: nrdA C9E50_RS22615 hypoxanthine cysteine residues 4-aminobutyrate lipoyl synthase: lipA demethylase C9E50_RS21090 4 RsmH: rsmH 2 RlmG: rlmG TruA: truA (2E)-3-methyl- decarboxylase: psd α msbB diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- anaerobic 5-methylaminomethyl- gln 2-oxoglutarate lactoylglutathione reductase: fucO melA malQ melA an [apo BCAA an N - an N - C9E50_RS17780 38- 2 gabT mhpD phosphatidylglycerophosphatase -D-Kdo-(2->4) GMP diphosphate kinase: class 1b phosphoribosyltransferase: dehydrogenase: gly butanoyl-CoA YeaE: yeaE AlkB: alkB V: recC recB recD C9E50_RS23495 a pseudouridine N -succinyl- reductase beta-ketoacyl-ACP adenylo-succinate 2-thiouridine-forming transaminase: his 2-iminobutanoate/ (S)-lactate (S)-propane- 1402 1835 4,6-dioxohept- pyruvate (S)-4-hydroxy- beta- C: yfhb -α-D-Kdo-(2->6) (Kdo) -lipid meso-2,6-diaminopimeloyl- ribonucleoside- dCDP hypoxanthine CTP synthase hydroxyacylglutathione hydroxyacetone dehydrogenase E2 methylcytidine methylguanine myo-inositol 40 in tRNA L-ornithine 3-oxopropanoate serine a peptide synthase II: fabF 2 C9E50_RS06765 ribonucleoside- C9E50_RS23610 astD 1,2-diol 6 2-enedioate 2-oxohexanoate FabI: fabI an L-1-phosphatidylethanolamine -lipid A (E. coli) A, cold adapted glycine) tetrapeptide triphosphate phosphoribosyltransferase: methyltransferase: C9E50_RS14665 (glutamine 2-iminopropanoate acyl-CoA hydrolase GloC: gloC α-D- a non a short 1,4- α-D- protein] N -lipoyl-L-lysine in 16S rRNA in 23S rRNA ketoacyl- [+ 2 isozymes] diphosphate a [protein] 3- 2 L-asparagine quinone-dependent a sophorosyloxyfatty pyruvate RS24490 pyruvate guanylate kinase: adenylosuccinate reductase: nrdD C9E50_RS23610 mnmC succinate hydrolyzing) N - deaminase: dehydrogenase: a [pyruvate dehydrogenase a double stranded DNA galactosylated α acetate N-acetylneuraminate D-gluconate ACP a (5Z)-dodec- a (7Z)-3-oxotetradec-7-enoyl-[acp] dTTP nucleoside- reductase: nitrosothio- methylglyoxal degradation I hydroxyacylglutathione bifunctional L- L-lactate 5'-deoxyadenosine an adenine in DNA formaldehyde succinate galactopyranose -D-glucan acid acetate galactopyranose laurate an L-1-phosphatidyl-sn-glycerol C9E50_RS00800 lyase: purB IMP N-end rule pathway I (prokaryotic) semialdehyde : pyrG succinylglutamate L-glutamine C9E50_RS24990 C9E50_RS22700 met 6 an unsulfurated [sulfur carrier] with a RecA protein synthase 5-enoyl-[acp] diphosphate xanthine and a 5-methylaminomethyl- L-alanine imidazole-pyruvate hydrolase: gloB 1,2-propanediol dehydrogenase: lldD E2 protein] N -lipoyl-L-lysine galactose acceptor nrdF nrdE 34 degradation II loaded 3' overhang 7 IMP 2-thiouridine in tRNA [+ 7 isozymes] succinylglutamate acyl-CoA II: fabF beta- 3-oxo-cis-∆ - kinase: xanthosine salvage leucyl/phenylalanyl- NADP-dependent pyruvate dehydrogenase/ acyl-CoA succinate glu desuccinylase: astE asn dehydrogenase: (R)-lactate pyruvate beta- ketoacyl- tetradecenoyl-[acp] cardiolipin cardiolipin synthase: GDP AMP C9E50_RS06765 dUDP UTP tRNA 2- tRNA--protein succinate- glycerol synthetase: semialdehyde L-asparaginase 1: 3 gln C9E50_RS12270 dehydrogenase: an N - 1207 1618 747 an oxidized 6-O-α-mycolyl- a [protein]- ketoacyl- ACP reductase: fabG synthase ClsB: clsB C9E50_RS16930 selenouridine(34) transferase: semialdehyde UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N S-(2-hydroxyacyl) a guanine adenine a uracil α C9E50_RS01835 superpathway of pyrimidine ribonucleosides salvage xanthosine a [protein] dehydrogenase glutamate C9E50_RS11900 2-oxoglutarate a proteinogenic leukotriene-C4 [DNA] isoprimeverose choline 2,3- Ins(4)P -D-lyxopyranose NaMN a DNA segment superpathway of guanine and guanosine salvage dCTP nucleoside- anaerobic synthase C9E50_RS18745 dehydrogenase: glu gldA C1 Compound Utilization and Assimilation -acetylmuramoyl-L-alanyl-γ- methylcytosine glutathione in 16S rRNA in 23S rRNA in 23S rRNA asp nitroaromatic trehalose 6- L-tyrosine ACP [+ 3 isozymes] synthase a (3R,7Z)-3-hydroxytetradec- adenylate kinase: a [protein]- an N-terminal N-terminal L- (NAD + ): gabD synthase large imidazole-lactate L-asparaginase crotonyl-CoA amino acid dAMP diaminopropanoate D-lyxose/D- diphosphate ribonucleoside- pyrimidine/purine MnmH: mnmH S-nitrosoglutathione gabD (S)-propane- D-glutamyl-L-lysyl- D-alanine in DNA 16S rRNA 23S rRNA bifunctional glucose- 23S rRNA bifunctional UDP- compound recombinase phosphate phosphate synthase I: fabB 7-enoyl-[acp] C9E50_RS21100 cytidine L-cysteine arginyl-[protein] leucyl-L-arginine subunit: gltB 2: ansB mannose family aspartate/ NAD(P)H trehalose- protein- lauroyl-CoA dCTP deaminase: kinase: triphosphate nucleoside a 5-methylaminomethyl- enoyl-CoA 1,2-diol formaldehyde oxidation undecaprenyldiphospho- 5'-deoxynucleotidase: diaminopropionate (guanine(1207)-N(2) (adenine(1618)-N(6) 1-phosphatase/ (uracil(747)-C(5))- sugar hydrolase/ RecA: recA I: fabB 7 glu pyruvate formaldehyde oxidation carnitine tyrosine/aromatic tyrosine- beta- 3-hydroxy cis ∆ - C9E50_RS06765 reductase: nrdD 2-(S-geranyl) S-(hydroxymethyl) succinate asp DNA oxidative exodeoxyribonuclease alpha- hydroxyacylglutathione )-methyltransferase )-methyltransferase methyltransferase sugar isomerase: 5'-nucleotidase: nitroreductase: phosphatase: Ptd Gro ribonucleoside- guanosine C9E50_RS09365 phosphorylase: ppnP hydratase: VII (THF pathway) II (glutathione-dependent) muramoylpentapeptide beta-N- gamma- monooxygenase: yfdR ammonia-lyase: dpaL inositol phosphatase: aminotransferase: [+ 2 isozymes] phosphatase ketoacyl- tetradecenoyl-[acp] 2 cytidine deaminase: cdd 34 glutathione xylosidase: yicI C9E50_RS25815 C9E50_RS11915 otsB ADP thiouridine in tRNA leucyl/phenylalanyl- fadB demethylase glutamyltransferase: I: sbcB hydrolase: gloB 2 RsmC: rsmC 6 RlmF: rlmF RlmC: rlmC C9E50_RS21070 a DNA segment diphosphate purine-nucleoside acetylglucosaminyltransferase: [+ 2 isozymes] an N - an N - C9E50_RS17780 747 C9E50_RS18535 a reduced α α Etp: etp a 3-oxotetradecanoyl- ACP dehydratase: fabZ dehydrogenase: yeaX yeaW a 5-methyluracil β-D- , '-trehalose dUTP tRNA 2- tRNA--protein formaldehyde AlkB: alkB C9E50_RS02025 pyruvate 1207 1618 D-xylulose in reverse a [protein]- reductase: phosphorylase: deoD C9E50_RS21685 (S)-3- formaldehyde murG methylguanine methyladenine myo-inositol oxaloacetate nitroaromatic 6-α-mycolate [acp] synthase ribonucleoside- uridine CMP xanthine selenouridine(34) transferase: 2'-deoxyadenosine in 23S rRNA ribosylnicotinate orientation L-tyrosine a (2E,7Z)-tetradeca- nucleoside- C9E50_RS08130 ribonucleoside- dUTP hydroxybutanoyl-CoA a 2'- α in 16S rRNA in 23S rRNA compound II: fabF diphosphate pyrimidine/purine synthase S-(hydroxysulfenamide) C9E50_RS18745 a [protein] D-glucopyranose -D-xylopyranose a 2-hydroxy 3-oxotetradecanoyl- 2,7-dienoyl-[acp] diphosphate nrdA ribonucleoside- diphosphate diphosphatase: (d)CMP kinase: xanthine an N-terminal (S)-3- ditrans,octacis-undecaprenyldiphospho- UDP a cytosine in DNA formaldehyde succinate α γ deoxyribonucleoside [DNA] glutathione glycolaldehyde trimethylamine a (7Z)-3- reductase nucleoside pyrimidine-specific MnmH: mnmH glutathione N-terminal L- a 5,10- an -( -L-glutamyl) carboxylate [acyl-carrier protein] kinase: diphosphate reductase: C9E50_RS00840 C9E50_RS18625 phosphoribosyltransferase: L-lysyl-[protein] hydroxybutanoyl- S-(hydroxymethyl) N-acetyl-(N-acetylglucosaminyl)muramoyl- leukotriene-D4 5'-monophosphate oxotetradec- enoyl-ACP stearate biosynthesis Carbohydrate Biosynthesis subunit class 1b phosphorylase: ribonucleoside a 5-methylaminomethyl- leucyl-L-lysine methylenetetrahydrofolate γ -L-amino acid reductase: fabG C9E50_RS06765 reductase C9E50_RS08130 uridine kinase: C9E50_RS22615 CoA glutathione L-alanyl- -D-glutamyl-L-lysyl-D-alanine a (3R)-3- 7-enoyl-[acp] reductase FabI: fabI II (bacteria and plants) alpha: nrdA ribonucleoside- inosine/ ppnP [+ 2 isozymes] hydrolase RihA: rihA CDP superpathway of pyrimidine 2-(Se-phospho) 7 nrdA bifunctional 3-oxo-cis-∆ - diphosphate subunit C9E50_RS09360 selenouridine 34 in tRNA dehydrogeanse: formate hydroxytetradecanoyl- gluconeogenesis I guanosine kinase: xanthine purine-nucleoside dUMP uracil ribonucleoside nucleobases salvage methylenetetrahydrofolate tetradecenoyl- GDP-L-colitose enterobacterial common antigen biosynthesis alpha: nrdA tRNA 2- fadB hydrogenlyase 5-amino-4- a pseudouridine 1915 a double a DNA containing a guanine 1516 a double-stranded [acp] a (7Z)-tetradec-7-enoyl-[acp] UDP-N-acetyl- CMP-N- dTDP-L-rhamnose UDP-N-acetyl-D- reductase: class 1b C9E50_RS21085 phosphorylase: hydrolase RihC: rihC XMP hydroxylamine dehydrogenase/ coenzyme A an apo [peptidyl- PRPP a proteinogenic glutathione [DNA] coenzyme A 2-succinylbenzoate 3-hydroxypropanoate an mRNA L-cysteate DNA with lesion syringaldazine [acp] a palmitoyl-[acp] CMP-diacetamido- biosynthesis phosphoribosyltransferase: thymidylate phosphoribosyltransferase: uracil selenouridine(34) transcriptional imidazolecarboxyamide in 23S rRNA stranded DNA an apurinic/ in 16S rRNA Ins(6)P oligonucleotide met D-cysteine beta-hydroxyacyl- β-L-fucosamine acetylneuraminate biosynthesis glucosamine biosynthesis I nrdF nrdE ribonucleoside- deoD tRNA processing methenyltetrahydrofolate carrier protein] amino acid dGMP ATP reductase: fabG (S)-malate 8-epilegionaminic UDP-N-acetyl-α-D-glucosamine C9E50_RS22615 synthase: thyA C9E50_RS06865 uracil synthase acetoacetyl-CoA activator 23S rRNA bifunctional NADP- DNase: apyrimidinic site 16S rRNA bifunctional glucose- mRNA aspartate/ excinuclease polyphenol ACP dehydratase: beta-ketoacyl-ACP biosynthesis biosynthesis GDP-α-D- α diphosphate UMP uracil methionine- a (3R,7Z)-3- acid biosynthesis UDP-N-acetyl- α-D-glucopyranose D-glucopyranose -D-glucopyranose 1-phosphate hypoxanthine nucleoside-diphosphate phosphoribosyltransferase: cyclohydrolase FolD: folD FlhA: flhA (pseudouridine(1915)- dependent 3-hydroxy (guanine(1516)-N(2) oligoribonuclease: tyrosine/aromatic ABC subunit D-cysteine C9E50_RS01830 synthase I: fabB UDP-N-acetyl- II (bacteria) mannose UDP-N- reductase: dTMP MnmH: mnmH acetyl-CoA C- adenine 5'-deoxynucleotidase: C9E50_RS16350 1-phosphatase/ interferase HigB: oxo-acid oxidase: hydroxytetradec- a 3-oxooctadecanoyl- α-D-glucosamine UDP-N-acetyl- 1-phosphate 6-phosphate GDP- phosphoribosyltransferase: (d)CMP kinase: kinase: C9E50_RS06765 C9E50_RS06865 a 5-methylaminomethyl- a polycistronic tRNA precursor a 5,10- 4'-phosphopantetheinyl gamma- exodeoxyribonuclease N(3))-methyltransferase o-succinylbenzoate- acid dehydrogenase/ V: C9E50_RS26410 )-methyltransferase C9E50_RS25410 aminotransferase: adenylate cyclase: UvrC: uvrC desulfhydrase: α α glucose-6- nrdF nrdE acyltransferase [+ 2 isozymes] phosphoribosyltransferase: yfdR [+ 2 isozymes] inositol phosphatase: C9E50_RS03740 transaminase: pgeF [+ 2 isozymes] beta-ketoacyl-ACP [acp] -D-glucosamine -D-glucosamine glucose-1-phosphate acetylglucosamine glucose-1-phosphate guanine dTMP kinase: UMP 34 methenyltetrahydrofolate III: xthA RlmH: rlmH -CoA ligase: menE RsmJ: rsmJ C9E50_RS18535 C9E50_RS27440 dcyD tetramethoxy 7-enoyl-[acp] mannose 4,6- C9E50_RS23610 C9E50_RS18625 2-selenouridine ammonium transferase AcpT: acpT glutamyltransferase: an N 3 - 3-hydroxypropionate [+ 2 isozymes] a 2'- an N 2 - C9E50_RS17780 a nucleoside 5'- ybdL [+ 3 isozymes] ∆ 7 synthase II: fabF thymidylyltransferase phosphate 2-epimerase (non- thymidylyltransferase FadA: fadA C9E50_RS21125 a 5'-phosphooligonucleotide an mRNA fragment DNA without a (2E)-tetradec- 3-hydroxy cis NAD-dependent UDP-2-acetamido- dehydratase: C9E50_RS16680 UMP kinase: pyrH (d)CMP kinase: in tRNA bifunctional S-formylglutathione [+ 2 isozymes] C9E50_RS02025 1915 dehydrogenase deoxyribonucleoside 1516 3-sulfopyruvate 4-(methylsulfanyl) pyruvate azobismethylene (R)-3- malate NAD-dependent α RfbA: rfbA isomerase: hydrolyzing): GTP dGDP dADP ATP methylpseudouridine methylguanine myo-inositol monophosphate cyclic-AMP 2-enoyl-[acp] -tetradecenoyl- malic enzyme: UDP-2-acetamido- N-acetyl- -D- gmd di-trans,octa-cis- RfbA: rfbA GMP pyrimidine ribonuclease E: [+ 2 isozymes] methylenetetrahydrofolate YdfG: ydfG 2'-deoxyguanosine -2-oxobutanoate lesion quinine a (9Z)-3-oxohexadec-9-enoyl-[acp] hydroxystearoyl- 2,6-dideoxy- dTDP-α-D-glucose C9E50_RS26245 dTDP UDP C9E50_RS18625 a 2'- in 23S rRNA 5'-monophosphate in 16S rRNA [acp] dehydrogenase: malic enzyme: 2,6-dideoxy- mannosamine C9E50_RS27555 undecaprenyl phosphate UDP-N-acetyl-α-D-glucosamine α C9E50_RS16745 ribonuclease E: S-formylglutathione 4-(2'-carboxyphenyl) enoyl-ACP [acp] C9E50_RS13980 ADP-L-glycero-β-D-manno β-L-arabino- F6P GDP- dTDP- -D-glucose nucleobases salvage II UMP kinase: pyrH acetyl-CoA dehydrogenase/ a holo [peptidyl- AICAR α γ deoxyribonucleoside [DNA] 3-oxopropanoate dehydratase: C9E50_RS13980 C9E50_RS13980 β-L-arabino- dTDP-glucose 4,6- α nucleoside- nucleoside-diphosphate C9E50_RS16745 hydrolase YeiG: 3',5'-ADP an -( -L-glutamyl) -4-oxobutyryl-CoA reductase 3-oxo-cis-∆ 9 - reductase: fabG -heptose biosynthesis hex-4-ulose mannose 4,6- UDP-N-acetyl- -D-mannosamine dTDP-glucose 4,6- methenyltetrahydrofolate carrier protein] L-cysteinylglycine 5'-monophosphate fabZ hex-4-ulose dehydratase: rffG UDP-N-acetylglucosamine-- anaerobic nucleoside- nucleoside- anaerobic cytosine diphosphate kinase: C9E50_RS06765 UDP exoribonuclease II: C9E50_RS08495 -L-amino acid FabI: fabI hexadecenoyl-[acp] a (3R)-3- glutamine-- dehydratase: dehydratase: rffG queuosine a tRNA precursor with a 5' Carbohydrate Degradation cyclohydrolase FolD: folD a (2E,7Z)- D-sedoheptulose dTDP-4-dehydro-6- UDP-N-acetyl-D- undecaprenyl-phosphate N- ribonucleoside- diphosphate diphosphate ribonucleoside- cytosine deaminase: codA kinase: C9E50_RS14770 S-formylglutathione reductase: fabG hydroxyoctadecanoyl- N-acetyl-D- fructose-6- gmd UTP nucleoside-diphosphate biosynthesis I (de novo) extension and a long 3' trailer an N 10 - tetradeca-2,7- 7-phosphate deoxy-α-D-glucopyranose GDP-4-dehydro- mannosamine dTDP-4-dehydro-6- triphosphate kinase: kinase: triphosphate C9E50_RS06765 a tRNA precursor with hydrolase: fghA a myristoyl-[acp] [acp] oxaloacetate D-sedoheptulose mannosamine phosphate acetylglucosaminephosphotransferase: wecA kinase: C9E50_RS06765 α undecaprenyl-diphospho-N-acetylmuramoyl-L- a methylated β an N-terminal L- 967 UDP-2-acetamido- α-D-rhamnose dehydrogenase: deoxy-α-D-glucopyranose uracil a 5' extension and formyltetrahydrofolate UDP-N-acetyl- -D-glucosamine UDP-N-acetyl-α-D-muramoyl- a single- an [amino group carrier protein]-C- selaginose N-acetyl- - 3-heptaprenyl-4- a cytosine a [phospholipid]- an insertion sequence a (2E,4Z)- D-glyceraldehyde a ribonucleoside a phosphate phosphoenol dienoyl-[acp] a (3R,9Z)-3-hydroxyhexadec- beta-hydroxyacyl- pyruvate UDP-4-amino- 7-phosphate transaminase reductase: nrdD C9E50_RS06765 C9E50_RS06765 reductase: nrdD dTTP preQ superpathway of glucose and xylose degradation alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine D-alanyl-D-alanine 2-oxoglutarate nucleobase alanyl-[S5 protein an acyl phosphate spermidine an aldehyde enoyl-ACP 2,6-dideoxy-β-L- α wecC α dTDP-4-amino-4,6- uracil CTP synthase (glutamine UTP 0 a short 3' extension D-arabinose degradation I D-galactosamine and N- L-lyxose degradation glucose and glucose-1-phosphate degradation D-arabinose formate L-alanyl-γ-D-glutamyl-L-lysine stranded RNA terminal-γ-(L-ornithyl)-L-glutamate neuraminate hydroxybenzoate in 16S rRNA palmitoleate element IS30 dienoyl-CoA 5'-monophosphate monoester pyruvate beta- 9-enoyl-[acp] ACP dehydratase: 4,6-dideoxy- isomerase: lpcA UDP- -D- (isomerizing) N-acetyl- -D- NADPH-dependent 7- formyltetrahydrofolate within DNA of 30S ribosome] 16S rRNA cyclopropane fatty NADPH-dependent aldehyde aldehyde reductase phosphoenolpyruvate D-glycero-D- lyxo-4-hexulose α dideoxygalactose phosphoribosyltransferase: hydrolyzing): pyrG exoribonuclease II: ribonuclease D-glucopyranose acetyl-D-galactosamine degradation II undecaprenyldiphospho- succinylornithine/ 30S ribosomal 4-hydroxy-3- transposase: spermidine N1- 5'/3'- alkaline 3-hydroxy cis ∆ 9 - C9E50_RS01830 N-acetyl-β- dTDP-4-dehydro- galacturonate : glmS UDP-N-acetyl- -D- glucosaminyldiphospho- CTP synthase (glutamine cyano-7-deazaguanine ribonuclease D: deformylase: purU dehydrogenase pyruvate ketoacyl- carboxykinase phosphoenolpyruvate manno-heptose N-acetyl-β- C9E50_RS14770 ribonuclease PH: D-arabinopyranose degradation α acetylornithine kojibiose protein S5 alanine polyprenylbenzoate (cytosine(967)-C(5) acyl phospholipid C9E50_RS06175 acylphosphatase: acetyltransferase: 2,4-dienoyl- nucleotidase dehydrogenase FabI: fabI hexadecenoyl-[acp] [+ 2 isozymes] L-idosamine β-L-rhamnose biosynthesis I 2-GDP- mannosaminuronate ditrans,octacis-undecaprenol transaminase: rffA dGTP dATP C9E50_RS06865 hydrolyzing): pyrG reductase QueF: queF C9E50_RS11695 P protein 6-phosphate Entner-Doudoroff pathway I β-L-lyxopyranose -D-glucopyranose 1-phosphate D-arabinopyranose muramoylpentapeptide beta-N- UDP-N-acetylmuramoyl- DNA oxidative N-acetylneuraminate iron-sulfur phosphatase: kinase: pyk ACP (ATP): pckA synthase: ppsA 7-phosphate neuraminate D-glucosamine ribonuclease D: N-acetyl-D- polyribonucleotide transaminase: astC phosphorylase: N-acetyltransferase: decarboxylase: ubiD )-methyltransferase synthase: [+ 4 isozymes] C9E50_RS18335 speG CoA reductase: SurE: surE iron-sulfur (from UDP-D- preQ C9E50_RS00825 component: rnpA glucose-6- L-lyxose L-fucose formate acetylglucosaminyltransferase: tripeptide--D-alanyl-D- lyase: nanA subunit: paoA phoA synthase a (7Z)-tetradec- dehydratase: fabZ α 6-phosphate [(2S,3S,6R)-5- dTDP-4-amino-4,6- UMP CTP CTP 1 L-fucose galactosamine demethylase nucleotidyltransferase: pnp an [amino group carrier protein]- RsmB: rsmB C9E50_RS12445 an insertion 8 C9E50_RS03750 subunit: paoA a (2E)-octadec- bifunctional D-glycero- UDP-N-acetyl-β- UDP- -D- lipopolysaccharide N- C9E50_RS11695 D-glucopyranose murG ycjT an N-terminal N-acetyl-rimJ 967 a [phospholipid]-8- N - [+ 3 isozymes] II: fabF 7-enoyl-[acp] glucuronate) amino-6-methyl- dideoxy-α-D-galactose a tRNA precursor with phosphate 6-phosphate isomerase: isomerase: alanine ligase: murF AlkB: alkB C-terminal-γ-(L-glutamate 5- 2-heptaprenylphenol a 5-methylcytosine sequence IS30 with a carboxylate a (2E)-2- an alcohol pyruvate a (2E,9Z)-hexadeca- 2-enoyl-[acp] phosphoenol beta-D-manno- L-pneumosamine glucuronate phosphoglucosamine acetylmannosaminouronosyltransferase: rffM 6-phosphate isomerase: fucI bifunctional glucose- L-alanyl-[S5 protein (2-hexylcyclopropyl) acetylspermidine (R)-glycerate a ribonucleoside a carboxylate 3,6-dihydro- tRNA-guanine a short 3' extension dehydrogenase: rhaA fucI semialdehyde-2-yl)-L-glutamate in 16S rRNA integrated transposon enoyl-CoA beta- beta- 2,9-dienoyl-[acp] pyruvate UDP-2,4- heptose-7-phosphate dTDP-β-L-rhamnose dTDP-4-amino-4,6- N-acetylglucosamine- 1-phosphatase/ alpha-D-glucose β N-acetyl-β-D- of 30S ribosome] octanoate enoyl-ACP CMP-N-acetyl- mutase: glmM 2H-pyran-3-ol] transglycosylase: tgt zwf glucose-6- D-ribulose L-xylulose D-ribulose ditrans,octacis-undecaprenyldiphospho-N- UDP-N-acetyl-α-D-muramoyl-L-alanyl- a nucleoside a single- -D-glucopyranose α α pyruvate ketoacyl- ketoacyl- diacetamido- kinase/D-glycero- β UDP-α-D- N-acetyl-β-D-mannosaminuronyl- dideoxy-D-galactose 6-phosphate inositol phosphatase: phosphate-specific UDP a nucleobase , -trehalose mannosamine reductase phosphopyruvate -neuraminate α-D-glucosamine a tRNA precursor 6-phospho phosphate β γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine formaldehyde succinate stranded RNA 1-phosphate ACP ACP enoyl-ACP 2,4,6-trideoxy- beta-D-manno- galacturonate (1->4)-N-acetyl-α-D- acyltransferase: rffC a 7-aminomethyl-7- deacetylase: nagA C9E50_RS17780 phosphoglucomutase: acetyl-(N-acetyl- -D-glucosaminyl)muramoyl-L- within DNA diphosphate FabI: fabI hydratase: 34 with a 5' extension ribonuclease PH: ribonuclease D: L-fuculokinase: ribulokinase: reductase FabI: fabI fatty acid elongation -- saturated β-L-idopyranose UDP-N-acetyl- 1-phosphate glucosaminyl-diphospho- deazaguanosine in tRNA D-glucono- dehydrogenase: C9E50_RS20110 alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthase synthase C9E50_RS05410 heptose 1-phosphate β dTDP-4-acetamido-4,6- C9E50_RS00825 C9E50_RS11695 fucK N-acetylglucosamine- glucose-1- araB -L-fucosamine bifunctional UDP-N- α 1,5-lactone zwf I: fabB I: fabB a stearoyl-[acp] adenylyltransferase 2-GDP- ditrans,octacis-undecaprenol dideoxy- -D-galactose tRNA preQ1(34) S- 6-phosphate L-xylulose phosphatase: yihX 2-phospho- acetylglucosamine adenosylmethionine ribonuclease: rnpA 6-phosphogluconolactonase: 6-phospho glucokinase: D-ribulose a pyrimidine a palmitoleoyl-[acp] HldE: hldE [(2S,3S,6R) D-ribulose 1-phosphate deacetylase: nagA 5-phosphate glucosyl-(heptosyl) - UDP-α-D-glucuronate adenine 1518 / uridine 955/2504/ uridine 2457 an N-acyl-D- a double a uracil 1939 a (2E,4E)- a [protein]-L- an adenosine 34 a 3-oxohexadecanoyl- beta- an acetoacetyl-[acp] D-glycerate β colanic acid building blocks biosynthesis diphosphorylase/ TDP-N-acetylfucosamine:lipid II N- C9E50_RS19665 D-glucono- C9E50_RS07380 5-phosphate 3 D-glucopyranose maltopentaose glycyl-glycine glutathione glycerophosphoglycerol 2-keto-D-gluconate putrescine spermidine wound RNA gentisate HMP-PP D-glycero- -D- -5-imino-6- ribosyltransferase- Kdo -lipid A-phosphate ribonucleotide 1519 mannosamine proline (ω = 180) Arg2 ketoacyl- UDP-2,4- 1,5-lactone D-galactosamine L-ribulose-5- D-glucopyranose D-glucopyranose 6-phosphate 2 adenine in 16S rRNA 2580 in 23S rRNA in 23S rRNA stranded DNA in 23S rRNA dienoyl-CoA in [tRNA ] [acp] 2,3-bisphosphoglycerate- manno-heptose glucosamine-1- acetylfucosaminyltransferase: rffT isomerase QueA: queA D-gluconate 2-O-α-mannosyl-D- 2,5-didehydrogluconate 16S rRNA 23S rRNA recombination- 23S rRNA NADPH-dependent ATP-dependent peptidylprolyl tRNA ACP diacetamido- methyloxan-3-ol] L-fuculose- 6-phosphate phosphate 3- 23S rRNA N-acetylmannosamine spermidine N1- spermidine N1- gentisate 1,2- HMP-PP (R)-3- beta-ketoacyl-ACP independent 1,7-bisphosphate D-glucopyranose 6-phosphate phosphate N- 6-phosphate 6-phosphogluconolactonase: glycerate degradation reductase DkgB: dkgB (adenine(1518)-N(6)/ pseudouridine(955/ promoting (uracil(1939)-C(5)) 2,4-dienoyl- RNA helicase isomerase adenosine(34) 2,4,6-trideoxy-β- 34 4-alpha- nucleotide 5'- pseudouridine(2457) kinase: acetyltransferase: acetyltransferase: dioxygenase: phosphatase: synthase phosphoglycerate acetyltransferase (enterobacterial common antigen) an epoxyqueuosine in tRNA C9E50_RS19665 phosphate D-galactosamine- epimerase UlaE: UDP- gamma- hydroxypalmitoyl- synthase II: fabF stearate L-gulopyranose D-glycero- 5-oxo-L-proline metabolism 6-phosphogluconate 2-O-(6-phospho- glucanotransferase: glycerophosphodiester 2,5-didehydrogluconate monophosphate adenine(1519)-N(6))- 2504/2580) synthase RluE: rluE C9E50_RS03065 nuclease -methyltransferase speG speG CoA reductase: SrmB: srmB B: ppiB deaminase gtdA cof II: fabF mutase: gpmM GlmU: glmU -undecaprenyl diphosphate an uncharged tRNA aldolase: fucA 6-phosphate C9E50_RS25230 glucuronate:LPS(HepIII) glutamyltransferase: α [acp] beta-D-manno- D-gluconate α-D-mannosyl) trehalose degradation phosphodiesterase: ugpQ reductase DkgA: dkgA nucleosidase: ppnN dimethyltransferase synthase RluC: rluC 2457 an N-acyl- -D- RpnA: rpnA RlmD: rlmD 1 C9E50_RS03750 [+ 4 isozymes] [+ 8 isozymes] TadA: tadA alpha-D-glucose glucose-6-phosphate GDP-4-dehydro- tRNA dehydrogenase, malQ 955/ a pseudouridine 1939 N - 34 a (9Z)-3- palmitoleate a 3-oxoacyl-[acp] 3-phospho- heptose 1,7- N-acetyl-α-D- deaminase/ L-ribulose 5- D-glucono-1,5-lactone glycosyltransferase: waaH C9E50_RS02025 a pseudouridine mannosamine a 5-methyluracil N-acetylputrescine a (2E)-2- a [protein]-L- an inosine 3-maleylpyruvate HMP-P reductase: fabG an (11Z)-3-oxooctadec- acyl-CoA lipid III flippase a [protein] with a [protein] with decarboxylating: gndA 6-phosphate 2-deoxy-D-ribose degradation I -D-glycerate VI (periplasmic) 2,5-didehydro-D-gluconate 6 RsmA: rsmA1518 a 5'-phosphooligonucleotide an unwound RNA oxohexadec- phosphate-specific isomerase: 3,6-dideoxy- epoxyqueuosine(34) isomerase: N -dimethyladenine in 23S rRNA acetylspermidine ω Arg2 a (3R)-3- synthetase: D-glycerate bisphosphate 7- glucosamine DHAP glycolaldehyde phosphate superpathway of Aromatic Compound Degradation 2504/2580 in 23S rRNA 6-phosphate in 23S rRNA enoyl-CoA proline ( = 0) in [tRNA ] 11-enoyl-[acp] C9E50_RS26245 α WzxE: wzxE reductase QueG: queG an N-terminal an N-terminal D-ribulose 6 1519 9-enoyl-[acp] 2,4-diacetamido- phosphoglucomutase: -D-mannose phosphogluconate C9E50_RS03480 α α phenylethylamine 4-hydroxyphenylacetate 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation glucosyl-(heptosyl) - a pyrimidine base D-ribose 5- /N -dimethyladenine hydroxyhexadecanoyl- C9E50_RS01835 phosphoglycerate phosphatase: 1-phosphate L-ribulose-5- , -trehalose 3 UDP maltose maltotetraose γ-L-glutamyl- glycerol sn-glycerol 3-oxo-cis-∆ 9 - β C9E50_RS20110 (enterobacterial common antigen) L-glutamine L-glutamate 5-phosphate dehydratase: edd 2-deoxy-D-ribose (R)-glycerate degradation L-cysteinylglycine phosphate in 16S rRNA [acp] 3-oxo-cis-vaccenoyl- 2,4,6-trideoxy- - gmhB a queuosine 34 in tRNA D-tagatofuranose phosphate 4- degradation glucosyluronate-Kdo 3-phosphate [+ 3 isozymes] kinase: bifunctional UDP-N- -undecaprenyl diphosphate 2 glycylglycine beta-hydroxyacyl- hexadecenoyl- L-gulopyranose D-glycero-β-D- F6P N 6 -L-threonylcarbamoyladenosine 37 6-phosphate -lipid A-phosphate [acp] reductase: fabG beta- C9E50_RS04555 acetylglucosamine ribulose-phosphate epimerase: glycerate 2-phenylethylamine (4-hydroxyphenyl) 3-phenylpropanoate ACP dehydratase: [acp] stearoyl-CoA manno-heptose α -modified tRNA biosynthesis ribose-5- KDGP D-gluconate alpha,alpha- ketoacyl- -D-glucopyranose 1-phosphate diphosphorylase/ GDP-β-colitose tagatose-6- araD 2-kinase: acetate C9E50_RS01830 reductase: fabG a (3R,11Z)-3-hydroxyoctadec- 1-phosphate mannose-6-phosphate glutathione 3-epimerase: phosphate glycolate trehalase TreF: treF 3-phenylpropionate/ ACP 13-DPG glucosamine-1- a [protein] with phosphate L-ribulose-5- garK α-Kdo-(2->4)-α-Kdo- 1407 2604 65 6-O-cis-keto- 2-deoxy-D- a (3R,9Z)-3- 11-enoyl-[acp] UTP--glucose-1-phosphate isomerase: manA γ-L-glutamyl C9E50_RS02345 isomerase 2-deoxy-D-ribose cinnamic acid dioxygenase: an L-1- D-glucopyranose maltohexaose acetate 3-hydroxy-5- sn-glycero-3- (R)-glycerate maltohexaose CMP a cytosine a uridine (Z)-3- a uridine a [protein] Ser/Thr (2R,3S)-3- a supercoiled [+ 2 isozymes] synthase 5,7-diacetamido- bifunctional D-glycero- phosphate N- an N-terminal 5- thr D-xylose KHG/KDPG kinase: pfkA phosphate 4- (3,4-dihydroxyphenyl) (2->6)-lipid IV (E. coli) spermine N-ethylmaleimide an aldehyde mycolyl-trehalose AIRs glucose 6- hydroxyhexadec- a (3R)-3- uridylyltransferase RpiA: rpiA 5-phosphate 2-phospho- phenylacetaldehyde C9E50_RS06640 A phosphatidylethanolamine oxohexanoyl-CoA phosphoethanolamine in 16S rRNA in 23S rRNA ureidoacrylate in tRNA isopropylmalate duplex DNA beta-hydroxyacyl- a 2,3,4-saturated type I 3,5,7,9- beta-D-manno- acetyltransferase glutathione-specific γ- oxo-L-proline 5-phosphate threonylcarbamoyl- aldolase: D-tagatofuranose epimerase UlaF: aldose 1-epimerase: acetate glyoxylate/hydroxypyruvate 16S rRNA peroxyureidoacrylate/ ATP-dependent aldehyde 6-phosphate phosphate a (2E)-hexadec- 9-enoyl-[acp] I: fabB hydroxyacyl-[acyl- GalF: galF D-mannopyranose 6-phosphate GDP-D-perosamine xylose D-xylulose D-glycerate C9E50_RS06645 23S rRNA tRNA serine/threonine spermidine N1- 3-isopropylmalate aminoimidazole 9 ACP dehydratase: fatty acyl-[acp] glyceraldehyde- tetradeoxy-L- C9E50_RS06615 nucleotide 5'- N-ethylmaleimide trehalose- hexitol 2-enoyl-[acp] 3-hydroxy cis ∆ beta-hydroxyacyl-carrier protein] heptose-7-phosphate GlmU: glmU glutamylcyclotransferase: AMP synthase: 5-phosphate D-ribose 5- C9E50_RS11460 1,6-bisphosphate C9E50_RS25225 deoxyribose- 3-(3-hydroxyphenyl)propanoate 4-alpha- reductase GhrB: ghrB (cytosine(1407)-C(5) pseudouridine(2604) ureidoacrylate pseudouridine(65) protein kinase: acetyltransferase: dehydratase: helicase: ferredoxin riboside kinase: C9E50_RS01830 triose- 3-phosphate glycero-D-galacto- UTP--glucose-1-phosphate biosynthesis isomerase: [+ 2 isozymes] 3-(5,6-dihydroxycyclohexa- kdo(2)-lipid A acetate CoA- alpha-glucosidase: monophosphate reductase: nemA phosphatase: phosphatase -hexadecenoyl- ACP dehydratase: kinase/D-glycero- phosphomannomutase UDP-N-acetyl- C9E50_RS15485 C9E50_RS14885 phosphate D-xylulose phosphate α β glucanotransferase: glycerophosphodiester glyoxylate/hydroxypyruvate )-methyltransferase synthase RluF: rluF amidohydrolase synthase TruC: truC C9E50_RS27165 speG leuC leuD C9E50_RS12490 oxidoreductase: C9E50_RS07515 enoyl-ACP phosphate dehydrogenase: non-2-ulosonate uridylyltransferase glycogen biosynthesis I (from ADP-D-Glucose) xylA -D-glucopyranose -D-glucopyranose 1,3-dien-1-yl)propanoate phosphoethanolamine transferase YdiF: C9E50_RS03755 nucleosidase: ppnN otsB HxpB: hxpB [acp] [+ 2 isozymes] C9E50_RS17580 beta-D-manno- CpsG: cpsG α α D-glyceraldehyde tagatose- phosphodiesterase: ugpQ reductase GhrA: ghrA RsmF: rsmF 2604 RutB: rutB 65 [+ 4 isozymes] C9E50_RS12385 -D-glucosamine GDP- -D-mannose L-threonylcarbamoyladenylate 5-phosphate aldolase: 2-hydroxy-5- 7''-transferase: eptB malQ 1407 a pseudouridine a pseudouridine a [protein] (L-serine/L- (2S)-2- 2-deoxy- reductase isomerase: gap GalU: galU pyruvate 3-(3-hydroxy- C9E50_RS12275 a 5-methylcytosine (Z)-3- N 1 -acetylspermine N-ethylsuccinimide a single trehalose-cis-keto- AIR dehydratase: a (2E,11Z)-octadeca- [+ 2 isozymes] heptose 1-phosphate phosphomannomutase dTDP-N-acetylviosamine GDP-mannose synthase type 1 TsaC: tsaC D-xylulose 3-phosphate bisphosphate deoC phenylacetate hydroxypyruvate in 23S rRNA in tRNA isopropylmalate a carboxylate D-glucose FabI: fabI tpiA 5-oxo-L-proline (L-threonylcarbamoyl) transketolase: tkt D-galactose degradation I (Leloir pathway) carboxymethylmuconate 2,3-dihydroxy-2,3- phenyl)propionate/ in 16S rRNA aminoacrylate threonine) phosphate stranded DNA mono-mycolate fabZ D-glyceraldehyde adenylyltransferase α CpsG: cpsG D-glucopyranose 6-phosphate biosynthesis 4,6-dehydratase: type I aldolase: D-ribofuranose cytosine 2,11-dienoyl-[acp] DHAP UDP- -D-glucose adenylate transketolase: tkt semialdehyde dihydrophenylpropionate 3-hydroxycinnamic 7-O-[2-aminoethoxy(hydroxy) D-glucopyranose maltopentaose a (2E,9Z)- 3-phosphate CMP-5,7- HldE: hldE gmd 5-oxoprolinase: xylulokinase: D-sedoheptulose D-glyceraldehyde glyceraldehyde- gatY gatZ fucose degradation D-glyceraldehyde a 1,2-diacyl-sn-glycerol maltopentaose maltose 3-hydroxy-5- ethanolamine sn-glycerol 5-phosphate a palmitoyl-[acp] α α-D-glucopyranose 2-hydroxy-5- acid hydroxylase: phosphoryl]-α-D-Kdo-(2->4) acetyl-CoA hexadeca-2,9- enoyl-ACP ADP-D-glycero-β- -D-mannose 1-phosphate alpha-D-glucose tRNA (adenosine(37)-N6)- xylB 7-phosphate 3-phosphate β-D-galactopyranose acetaldehyde dehydrogenase: oxohexanoate 3-phosphate diacetamido- 1-phosphate GDP-mannose pxpA 3-phosphate tagatose- 3-phosphate trehalose degradation I (low osmolarity) carboxymethylmuconate C9E50_RS21730 -α-D-Kdo-(2->6)-lipid IV dienoyl-[acp] reductase FabI: fabI enoyl-ACP a trans-2- D-manno-heptose UDP-glucose 4- UDP-glucose 6- phosphate-specific glucose-1-phosphate threonylcarbamoyltransferase D-xylulose C9E50_RS06630 A a 2,3,4-saturated 3,5,7,9- 4,6-dehydratase: pxpC pxpB dehydrogenase: aldose 1- bisphosphate β-L-fucopyranose acetaldehyde semialdehyde enoyl-ACP reductase enoyl-[acyl- epimerase GalE: galE dehydrogenase: mannose-1-phosphate phosphoglucomutase: thymidylyltransferase complex dimerization 5-phosphate α α phenylacetyl-CoA fatty acyl-[acp] tetradeoxy-L- ADP- gmd transaldolase A: gap epimerase: aldolase: dehydrogenase , -trehalose dehydrogenase: gabD reductase carrier protein] class II fructose- C9E50_RS09570 guanyltransferase: cpsB C9E50_RS20110 GDP-4-dehydro- subunit type 1 TsaB: tsaB cinnamate and 3-hydroxycinnamate α-D-Kdo-(2->4)-α-D- an L-1- a 1-O-(alk-1-enyl)-sn-glycero- a 2,3,4-saturated a cytosine 1962 uridine 2605 a cytidine 34 in a uridine 13 propane- a secondary a cis-vaccenoyl-[acp] FabI: fabI glycero-D-galacto- glyceromanno- α RfbA: rfbA glu C9E50_RS07050 kbaY kbaZ L-fucose (acetylating): 6-phosphate 2,3-DHP D-glucopyranose a maltodextrin acetate (R)-glycerate maltoheptaose c-di-GMP tellurite a cytosine in DNA isovaleryl-CoA an aryl sulfate 7,8-dihydropterin glycerol 1- UDP- -D-galactose α-D-glucopyranose dTDP-α-D-glucose α-D-rhamnose [+ 2 isozymes] C9E50_RS06615 5-carboxymethyl-2- degradation to 2-hydroxypentadienoate Kdo-(2->6)-lipid A (E. coli) met his FabI: fabI bisphosphate non-2-ulosonate heptose 6- α transaldolase: tal 13-DPG mutarotase: fucU phosphatidylethanolamine 3-phosphoethanolamine fatty acyl CoA in 23S rRNA in 23S rRNA [elongator tRNA ] in tRNA 1,3-diamine alcohol phosphate palmitate UDP-α-D-glucuronate GDP- -D-mannose 1-phosphate GDP-perosamine an N 6 -L- [+ 2 isozymes] C9E50_RS21710 hydroxymuconate glyoxylate/hydroxypyruvate cyclic-guanylate- 23S rRNA sulfatase: zinc-binding aldolase: fbaA epimerase: rfaD dTDP-glucose 4,6- D-glyceraldehyde trehalose degradation II (cytosolic) alpha,alpha- 2,3-dihydroxyphenylpropionate/ 23S rRNA tRNA(Met) cytidine tRNA tellurite resistance spermidine N1- DNA methylase: isovaleryl-CoA guanine hexitol a palmitoleoyl-[acp] (Kdo) -lipid A enoyl-ACP synthase: periplasmic disulfide bond formation threonylcarbamoyladenine 37 DHAP α 2-(1,2-epoxy-1,2- cinnamate reductase GhrA: ghrA specific (cytosine(1962)-C(5) C9E50_RS13880 alcohol histidine 2 GDP-mannose 4,6- α -L-fucopyranose 2, 3-dihydroxicinnamic 4-alpha- pseudouridine(2605) acetyltransferase: pseudouridine(13) methyltransferase acetyltransferase: C9E50_RS08845 dehydrogenase: deaminase: acyl-CoA ADP-L-glycero-β- glucose-1-phosphate dehydratase: rffG D-erythrose phosphoglycerate -D-galactopyranose 3-phosphate acetyl-CoA phosphotrehalase: kdo(2)-lipid A acetate CoA- alpha-glucosidase: ammonia-lyase: phosphatase biosynthesis II (P. putida) reductase dehydratase: gmd C9E50_RS09520 in tRNA F6P dihydrophenyl) acid 1,2-dioxygenase: glucanotransferase: lysoplasmalogenase: glyoxylate/hydroxypyruvate phosphodiesterase )-methyltransferase synthase RluB: rluB C9E50_RS06985 synthase TruD: truD TehB: tehB speG C9E50_RS25280 sulfatase: dehydrogenase: guaD synthetase: D-manno-heptose adenylyltransferase: dTDP-4-dehydro-6- two reduced a [DsbA protein] a [DsbB protein] 4-phosphate kinase: α,α-trehalose treC 3-phenylpropionate/ phosphoethanolamine transferase YdiF: C9E50_RS03755 [+ 3 isozymes] C9E50_RS19900 HpxA: hxpA α α FabI: fabI L-fucose acetyl-CoA C9E50_RS01905 reductase GhrB: ghrB PdeF: pdeF RlmI: rlmI 2605 4 34 13 C9E50_RS18895 C9E50_RS14610 C9E50_RS01835 cis-vaccenate -Kdo-(2->4)- - GDP-mannose 4,6- glgC deoxy-α-D-glucopyranose an electron- C9E50_RS04555 galactokinase: C9E50_RS21725 7''-transferase: eptB malQ 1962 a pseudouridine an N -acetylcytidine a pseudouridine N-(3-aminopropyl) a 5-methylcytosine 3-methylcrotonyl- 7,8- beta- β cysteine residues carrying a with reduced L- transketolase: tkt isomerase: fucI (3E,5R)-5-carboxy-2- cinnamic acid C9E50_RS12275 a 5-methylcytosine methanetelluronate glycerol [+ 3 isozymes] Kdo-(2->6)-lipid -D-fructose 1,6- PRPP biosynthesis dehydratase: gmd α transfer quinone galK (2Z,4E)-2-hydroxy-6- hydroxypyruvate [+ 5 isozymes] in 23S rRNA in [elongator tRNA met ] in tRNA acetamide in DNA CoA a phenol a ketone urocanate dihydrolumazine ketoacyl- a (1->4)-α-D-glucan ADP-α-D-glucose GDP- -D-perosamine in a protein disulfide bond cysteine residues transketolase: tkt 3-phospho- alpha,alpha- glucokinase: oxohept-3-enedioate dioxygenase: 5'-phosphoguanylyl(3'->5') in 23S rRNA IV (P. putida) bisphosphate oxonona-2,4-diene-1,9-dioate 7-O-[2-aminoethoxy(hydroxy) A cellulose α D-glycerate L-fuculose C9E50_RS06640 sn-glycero-3- D-glucopyranose maltohexaose guanosine palmitoyl-CoA ACP LpxL/LpxP class II fructose- D-ribose 5- GDP-4-dehydro- -D-rhamnose D-glyceraldehyde α-D-galactose trehalase TreF: treF D-glucopyranose C9E50_RS07380 α a 1,2-diacyl-sn-glycerol a maltodextrin maltose a fatty aldehyde a 2,3,4-saturated palmitoleate biosynthesis glycogen L-rhamnose 2,3- UDP-α-D-glucose L-rhamnose degradation I D-glucopyranose 2-oxepin-2(3H)- 2-hydroxy-6-ketonona-2,4- C9E50_RS06645 phosphoryl]- -D-Kdo-(2->4) phosphoethanolamine acetyl-CoA synthase family Kdo(2)- bisphosphatase: phosphate dTDP-viosamine 3-phosphate 1-phosphate L-fuculokinase: 6-phosphate α fatty acid biotin-carboxyl carrier protein assembly ribose-phosphate GDP-L-fucose synthase: fcl synthase degradation II diphosphoglycerate- ylideneacetyl-CoA dienedioate hydrolase: (2E)-3-(5,6- - -D-Kdo-(2->6)-lipid A II: fabF lipid IV(A) lauroyl/ glpX fucK β-D-glucopyranose α-D-glucopyranose cellulose pyrophosphokinase: GDP-L-fucose synthase: GlgA: glgA type I dependent α-L-rhamnopyranose (4Z)-2-oxohept- C9E50_RS21720 dihydroxycyclohexa- palmitoleoyl a [biotin carboxyl- UDP- 4-enedioate C9E50_RS15560 C9E50_RS09535 α glyceraldehyde- L-rhamnopyranose phosphoglycerate 1,3-dien-1-yl) an (S-diacyl-sn- a 2'- 516 an (11Z)-3- acyltransferase: F6P a (1->4)- -D-glucan L-fuculose 1-phosphate (2Z)-2-hydroxypenta-2,4-dienoate an L-1- a plant soluble a 2-acyl-1-lyso- long chain 3-nonaprenyl-4- a uridine 3-hydroxy-4- (S)-2- carrier protein]-L-lysine forming PRPP dTDP-N-acetylviosamine 3-phosphate mutase: gpmA L-rhamnose prop-2-enoate glyceryl)-L-cysteinyl- D-glucopyranose acetate pentanoyl-CoA (R)-glycerate maltopentaose deoxyribonucleoside 3-hydroxybenzoate 5,6-dihydrouracil 2-oxoglutaramate methylglyoxal pyrazinamide DHAP L-tartrate D-glucopyranose oxooctadec- lpxL GDP-4-dehydro-6-deoxy-β-L-galactose 3-oxo-5,6- phosphatidylethanolamine heteroglycan phosphatidylethanolamine polyphosphate hydroxybenzoate in 16S rRNA methyl-benzoate hydroxyglutarate bifunctional biotin- glucose-6- cellulose 1,4-alpha-glucan dehydrogenase: mutarotase: [apolipoprotein] glyoxylate/hydroxypyruvate 5'-monophosphate 11-enoyl-[acp] α-Kdo-(2->4) 2-phospho- melibiose degradation didehydrosuberyl- 2-keto-4-pentenoate 3-hydroxycinnamate 4-hydroxy-3- 16S rRNA 3-hydroxybenzoate 3-hydroxybenzoate NAD-dependent L-2- NADH- bifunctional L(+)-tartrate xylose -[acetyl-CoA- phosphate synthase branching gap L-rhamnofuranose rhaM L-fuculose- 5'-deoxynucleotidase: 2-oxoglutaramate methylglyoxal 3-oxo-cis- -α-Kdo-(2->6) GDP-L-fucose synthase: fcl D-glycerate D-glucopyranose CoA semialdehyde (4S)-4-hydroxy-2- hydratase: mhpD cis-3-(2- 4-alpha- reductase GhrB: ghrB polyprenylbenzoate pseudouridine(516) 6-monooxygenase: 6-monooxygenase: dihydropyrimidine hydroxyglutarate dependent nicotinamidase/ dehydratase: isomerase: carboxylase] ligase/ isomerase: catalytic enzyme: glgB a [DsbA protein] a [DsbB protein] phosphate acetate CoA- alpha-glucosidase: exopolyphosphatase: ppx C9E50_RS07855 amidase: yafV synthase: mgsA vaccenoyl- -(lauroyl)-lipid GDP-L-fucose synthase: an intra- an electron- phosphopyruvate β-L-rhamnopyranose oxoheptanedioate carboxyethenyl)- apolipoprotein N- glucanotransferase: lysophospholipase glyoxylate/hydroxypyruvate decarboxylase: ubiD synthase RsuA: rsuA C9E50_RS08590 C9E50_RS08590 dehydrogenase oxidase: lhgO methylglyoxal pyrazinamidase: ttdB ttdA xylA [acp] biotin operon C9E50_RS26245 subunit: with reduced L- carrying a 13-DPG aldolase: fucA melibiose 3,5-cyclohexadiene- transferase YdiF: C9E50_RS03755 [+ 2 isozymes] IV (P. putida) C9E50_RS09535 a glycogen protein disulfide transfer quinol hydratase: glucokinase: (S)-4-hydroxy-2-oxopentanoate 3-hydroxy-trans- acyltransferase: lnt malQ L2: pldB reductase GhrA: ghrA a 16S rRNA subunit PreA: preA reductase: ydjG pncA keto-D-fructose A bcsA cysteine residues disulfide bond L-rhamnose C9E50_RS12275 long chain a 2'- pyrazine-2- reductase: repressor BirA: birA D-glucopyranose C9E50_RS07380 1,2-diol cinnamate 2-nonaprenylphenol 516 gentisate 4-methylgentisate 2-oxoglutarate 2-oxoglutarate methylglyoxal oxaloacetate β C9E50_RS05410 3-oxo-5,6- hydroxypyruvate pseudouridine uracil hydroxyacetone fabG cellulose GDP- -L-fucose phosphoglycerate L-rhamnono- isomerase: dehydrogenase: polyphosphate deoxyribonucleoside carboxylate a [biotin carboxyl-carrier 6-phosphate DHAP (S)-lactaldehyde alpha-galactosidase: melA didehydrosuberyl- 4-hydroxy-2-oxovalerate hydroxylase: an N-acyl-(S-diacyl- a plant soluble 6 kinase: phosphoenol rhaA a 2-acyl-1-lyso- sn-glycero-3- D-glucopyranose maltotetraose a (3R,11Z)-3- protein]-N -biotinyl-L-lysine 1,4-lactone D-glucopyranose 6-phosphate aldolase: dmpG C9E50_RS06630 C9E50_RS21730 maltose a carboxylate hydroxyoctadec- α-Kdo-(2->4) Aminoacyl-tRNA Charging C9E50_RS04555 pyruvate CoA succinate semialdehyde phosphatidylethanolamine sn-glyceryl)-L- heteroglycan phosphoethanolamine acetyl-CoA pentanoate α keto-L-rhamnulose cysteinyl-[lipoprotein] 11-enoyl-[acp] - -Kdo-(2->6) 3-phospho- pyruvate D-galactopyranose D-glucopyranose acetaldehyde 2,3-dihydroxy- UDP-glucose:α- NADP-dependent beta-hydroxyacyl- -lipid A form tRNA charging D-glycerate kinase: pyk trans-cinnamate D-galactose- UDP-glucose succinate- acetaldehyde ACP dehydratase: C (P. putida) a [biotin carboxyl-carrier-protein 2,3-bisphosphoglycerate- L-rhamnonate pyruvate kinase I: trans-2,3- UDP-α-D-galactose α-L-fucosyl-(1->4)-[2/3-O-acetyl-α-L- 2-amino-6-[1-hydroxyethyl]- (3-aminopropyl) a pyrimidine nucleoside 3-decaprenyl-4- a uridine 55 3-hydroxy-5- a [protein]- a [protein]- semialdehyde 2,3- β α β π τ C9E50_RS01830 6 1-phosphate 4-epimerase L-arabinose dehydrogenase (acetylating) β seleno-L- a -D glucoside glyoxylate uroporphyrinogen-I an -limit dextrin maltose -D-fructofuranose hydroxypyruvate N -phospho- N -phospho- (S)-malate ribulose D-altropyranose dimer]-N -biotinyl-L-lysine independent C9E50_RS12370 chitobiose degradation dehydroadipyl-coA dehydrogenase: dihydroxycinnamate fucosyl]-(1->3)- -D-glucopyranosyl- 7-methyl-7,8-dihydropterin phosphonate hydroxybenzoate in tRNA methyl-benzoate trp a tRNA Trp lys a tRNA Lys a tRNA Ala ala his a tRNA His elongator tRNA Met met initiator tRNA Met met arg a tRNA Arg tRNA asp asp thr a tRNA Thr tyr a tRNA Tyr asn tRNA Asn gln a tRNA Gln leu a tRNA Leu cys a tRNA Cys pro a tRNA Pro ile a tRNA Ile phe a tRNA Phe gly a tRNA Gly L-rhamnonate uridylyltransferase: GalE: galE L-rhamnulofuranose degradation I : C9E50_RS21710 homocysteine glyoxylate/hydroxypyruvate L-histidine L-histidine [+ 2 isozymes] ser Val glu phosphoglycerate diphosphoundecaprenol 2-amino-4-hydroxy-6- 4-hydroxy-3- 4-alpha- tRNA 3-hydroxybenzoate hydroxypyruvate malate L-fucose acetyl-CoA ser a tRNA val a tRNA glu a tRNA pyruvate α galT gabD dioxygenase: 5-methyltetrahydropteroyltriglutamate- aminoalkylphosphonate uroporphyrinogen alpha-glucosidase: fructokinase: phosphohistidine phosphohistidine ribulokinase: a (2E,11Z)- mutase: gpmM dehydratase: -D-glucopyranose α N,N'-diacetylchitobiose colanic acid biosynthesis hydroxymethyldihydropteridine ribosylpyrimidine reductase GhrA: ghrA polyprenylbenzoate glucanotransferase: pseudouridine(55) 6-monooxygenase: isomerase: dehydrogenase isomerase: α-Kdo-(2->4) α-Kdo-(2->4) carboxylase, UDP- -D-galactose rhamnulokinase: L-arabinopyranose acetyl-CoA C9E50_RS21725 - homocysteine S- beta-glucosidase N-acetyltransferase: phnO decarboxylase: hemE C9E50_RS03755 C9E50_RS21515 phosphatase phosphatase araB octadeca-2,11- rhmD 1-phosphate 6'-phosphate succinate (2Z,4E,7E)-2- glycosyltransferase diphosphokinase: folK nucleosidase: rihB glyoxylate/hydroxypyruvate decarboxylase: ubiD malQ synthase TruB: truB C9E50_RS08590 C9E50_RS20900 (quinone): mqo fucI α α carboxyltransferase acetyl-CoA tryptophan-- lysine--tRNA ligase: lysS alanine--tRNA histidine--tRNA methionine--tRNA methionine--tRNA arginine--tRNA aspartate--tRNA threonine--tRNA tyrosine--tRNA asparagine-- glutamine--tRNA leucine--tRNA cysteine--tRNA proline--tRNA isoleucine-- phenylalanine--tRNA glycine--tRNA 2-phospho- rhaB L-arabinose chitin (3S)- methyltransferase: metE BglX: bglX α SixA: sixA SixA: sixA dienoyl-[acp] - -Kdo-(2->6) - -Kdo-(2->6) 2-dehydro- [1-(2-amino-7-methyl-4-oxo- reductase GhrB: ghrB a -limit dextrin 55 L(or D)-ribulose subunit beta: accD carboxylase serine--tRNA ligase: serS valine--tRNA ligase: valS D-glycerate D-gulosides kojibiose degradation hydroxy-6-oxonona- WcaC: wcaC (2-acetamidopropyl) a pseudouridine D-glucopyranose tartronate keto-D-psicose enoyl-ACP -lipid A form -lipid A form tRNA ligase: trpS lysine--tRNA ligase: lysS ligase: alaS ligase: hisS ligase: metG ligase: metG ligase: argS ligase: aspS ligase: thrS ligase: tyrS tRNA ligase: asnS ligase: glnS ligase: leuS ligase: cysS ligase: proS tRNA ligase: ileS ligase: pheS pheT ligase: glyQ glyS 3-deoxy-L- alpha-D-glucose L-rhamnulose isomerase: disaccharide hydroxyadipyl- 7,8-dihydro-3H-pteridin- coproporphyrinogen I 2-decaprenylphenol with short branches 3-methylgentisate F6P a [protein]- a [protein]- oxaloacetate 5-phosphate biotin carboxylase phosphopyruvate conversion to 2,4,7-triene-1,9-dioate SeMet phosphonate glycolate in tRNA semialdehyde reductase D (P. putida) A (P. putida) acetyl-CoA rhamnonate phosphate-specific 1-phosphate araA N-monoacetylchitobiosedeacetylase: chbG CoA 6-yl)]ethyl diphosphate D-ribofuranose a pyrimidine base L-histidine L-histidine subunit: accC hydratase: L-ribulose D-glucosides 2-hydroxy-6- β-D-galactosyl-(1->3)-α-L-fucosyl-(1-> a non glucosylated FabI: fabI carboxylase 2-keto-3-deoxy- ribose phosphoglucomutase: D-allose 6'-phosphate kojibiose UDP D-glucopyranose an L-tryptophanyl-[tRNA Trp ] an L-lysyl-[tRNA Lys ] an L-alanyl-[tRNA Ala ] an L-histidyl-[tRNA His ] an L-methionyl-[elongator tRNA Met ] an L-methionyl-[initiator tRNA Met ] an L-arginyl-[tRNA Arg ] an L-aspartyl-[tRNA asp ] an L-threonyl-[tRNA Thr ] an L-tyrosyl-[tRNA Tyr ] an L-asparaginyl-[tRNA Asn ] an L-seryl-[tRNA ser ] an L-glutaminyl-[tRNA Gln ] an L-leucyl-[tRNA Leu ] an L-cysteinyl-[tRNA Cys ] an L-prolyl-[tRNA Pro ] an L-isoleucyl-[tRNA Ile ] an L-valyl-[tRNA Val ] an L-phenylalanyl-[tRNA Phe ] a glycyl-[tRNA Gly ] an L-glutamyl-[tRNA Glu ] C9E50_RS05410 oxononadienedioate/ 4)-[2/3-O-acetyl-α-L-fucosyl]-(1->3)-β-D- D-glucose acceptor carboxyl transferase L-rhamnonate phosphorylation C9E50_RS20110 degradation rhamnulose- a D-guloside kojibiose a cis- subunit alpha: accA ribulokinase: D-guloside 3- 6-phospho-beta- phosphorylase: 2-hydroxy-6- glucopyranosyl-diphosphoundecaprenol α phosphoenol aldolase: 1-phosphate vaccenoyl-[acp] -Kdo-(2->4) β-D-ribopyranose D-glucopyranose araB dehydrogenase: glucosidase: ycjT 3-oxoadipyl-CoA oxononatrienedioate α a [carboxyl-carrier protein dimer]- pyruvate C9E50_RS08070 D-allopyranose aldolase: rhaD β-D-glucopyranose - -Kdo-(2->6) D-ribose 6-phosphate L-ribulose 5- C9E50_RS05735 hydrolase: 6 6 C9E50_RS14610 an N -L- α 5,6- a [protein]- N -carboxybiotinyl-L-lysine pyruvate a 3-dehydro- 1-phosphate 3-methyl-2- 5,10-methylene- [(S)-1- a double (Z)-2- a 5' triphospho- a 4-hydroxy-3- dCMP D-ribulose N-acetyl- - an aliphatic 2-methyl-1,4- -lipid A form pyranase: phosphate [+ 2 isozymes] C9E50_RS21720 37 maltotriose a glucan uroporphyrinogen-III coproporphyrinogen III thiosulfate xylan β-D-allopyranose kinase: pyk (S)-lactaldehyde oxobutanoate tetrahydromethanopterin threonylcarbamoyladenine 5-phosphate neuraminate dihydrothymine α ω N-phospho- B (P. putida) rbsD aldehydo-D-allose DHAP (S)-lactaldehyde D-guloside N-acetyl-D-glucosamine beta- aminoethyl]phosphonate stranded DNA methylureidoacrylate [mRNA] polyprenylbenzoate 5'-deoxynucleotidase: , -diamine benzoquinone pyruvate kinase I: L-ribulose-5- (2Z)-2-hydroxypenta- in tRNA uroporphyrinogen-III C- peroxyureidoacrylate/ RNA 4-hydroxy-3- N-acetylneuraminate NAD-dependent spermidine N1- NAD(P)H:quinone L-histidine thiosulfate alpha- D-ribose β-D-ribofuranose 6-phosphate 3-dehydro- 6-phosphate phosphoglucomutase: tRNA cyclic N6- aminoalkylphosphonate exodeoxyribonuclease yfdR phosphoribulokinase: porphyrinogen phosphohistidine cis-vaccenate C9E50_RS12370 phosphate 4- 2,4-dienoate 3-methyl-2-oxobutanoate 4-alpha- methyltransferase: cobA ureidoacrylate pyrophosphohydrolase: polyprenylbenzoate epimerase: dihydropyrimidine acetyltransferase: oxidoreductase: sulfurtransferase xylosidase: pyranase: lactose D-guloside 4- pgmB succinyl-CoA threonylcarbamoyladenosine(37) N-acetyltransferase: phnO V: recC recB recD [+ 2 isozymes] C9E50_RS02460 peroxidase: yfeX phosphatase D-mannose epimerase: hydroxymethyltransferase: glucanotransferase: uroporphyrinogen-III C- amidohydrolase rppH decarboxylase: ubiD C9E50_RS24725 dehydrogenase speG qorB GlpE: glpE yicI rbsD pyruvate degradation III epimerase: β-D-glucose synthase TcdA: tcdA 2'-deoxycytidine N-acetyl-β- subunit PreA: preA SixA: sixA degradation araD panB a cyclic N 6 -L- [(1S)-1- malQ methyltransferase: hemX RutB: rutB a 5'-phospho- a 2-(all-trans- D-ribulose-1,5- an aliphatic N- methyl-1,4- α β (S)-lactate C9E50_RS14605 6-phosphate a 5'-phosphooligonucleotide (Z)-2- coproporphyrin III neuraminate thymine a [protein]- sulfite -D-xylopyranose -D-allofuranose D-mannopyranose D-allulose 6- fructose degradation L-ribulose-5- a 3-dehydro- threonylcarbamoyladenosine acetamidoethyl]phosphonate precorrin-2 [mRNA] polyprenyl)phenol bisphosphate acetyl-diamine benzoquinol D-ribofuranose lactose methylaminoacrylate L-histidine D-lactate 6-phosphate phosphate phosphate 4- D-glucoside 37 in tRNA mannose-6- β a glucan D-glucopyranose dehydrogenase: ribokinase: -D-fructofuranose epimerase UlaF: D-glucoside 3- 2-dehydropantoate THMPT phosphate β-D- 1-phosphate C9E50_RS25225 ldhA rbsK 1-phosphofructokinase: dehydrogenase: (S)-lactate isomerase: galactopyranose D-xylulose C9E50_RS14600 D-ribofuranose manA fruK F6P β-D-fructose 1,6- 5-phosphate 2,5-diamino-6-(5- dUMP dTMP uridine (R)-lactate 5-phosphate F6P a D-glucoside phosphatidylglycerolphosphate [(R)-1- a uridine in tRNA (2-aminoethyl) a single a 23S rRNA an α-limit dextrin a β-D-galactoside D-sedoheptulose (R)-propane- a D-hexose bisphosphate phospho-D-ribitylamino) 1911/1915/1917 a [histone]-L-lysine 3-mercaptopyruvate 2-phosphoglycolate 5-methylcytosine 5-fluorocytosine (1-oleoyl, 2-palmitoyl) aminoethyl]phosphonate phosphonate stranded DNA uridine 5'-deoxynucleotidase: 5'-deoxynucleotidase: 1,2-diol pyrimidin-4(3H)-one tRNA dihydrouridine(16) 23S rRNA 3-mercaptopyruvate 4-alpha- phosphoglycolate galactoside O- uridine kinase: cytosine cytosine bifunctional phosphatidylglycerophosphatase aminoalkylphosphonate aminoalkylphosphonate deoxyribonuclease protein lysine yfdR yfdR fructokinase: lactaldehyde glucokinase: synthase DusC: dusC pseudouridine(1911/ sulfurtransferase: glucanotransferase: phosphatase: acetyltransferase: C9E50_RS09360 deaminase: deaminase: diaminohydroxyphosphoribosylaminopyrimidine A: pgpA N-acetyltransferase: phnO N-acetyltransferase: phnO IV: C9E50_RS08470 acetyltransferase: pat [+ 2 isozymes] [+ 2 isozymes] C9E50_RS21515 reductase: fucO C9E50_RS07380 deaminase/5-amino-6-(5-phosphoribosylamino) tRNA dihydrouridine 1915/1917) sseA malQ C9E50_RS02350 lacA codA codA [+ 2 isozymes] synthase RluD: rluD 2'-deoxyuridine a debranched a 6-acetyl-β- thymidine UMP uracil reductase RibD: ribD [(1R)-1- synthase DusB: dusB (2-acetamidoethyl) a [histone]-N 6 - D-sedoheptulose D-hexose 6- thymine 5-fluorouracil 1-oleoyl-2-palmitoyl- a 5'-phosphooligonucleotide a pseudouridine 1911/ pyruvate α glycolate (R)-lactaldehyde 5-amino-6-(5-phospho- a 5,6-dihydrouridine in tRNA -limit dextrin D-galactoside 1-phosphate phosphate 4-amino-4- phosphatidylglycerol acetamidoethyl]phosphonate phosphonate 1915/1917 in 23S rRNA acetyl-L-lysine an L-sorbose 1-phosphate a branched- D-ribitylamino)uracil deoxy-α-L- α D-fructose 1-phosphate chain N-acetyl- -D- arabinopyranosyl cys galactosamine methyl glutamate N,N'- an aliphatic sn-glycerol α D-mannose 6-phosphate amino acid maltose an an ditrans,octacis N-acetyl- -D-galactosamine 1-phosphate D-mannose guanine guanine D-fructose D-fructose D-fructose L-arabinose glutathione 1-phosphate D-galactose a sugar 6- a sugar 6- asp diacetylchitobiose sulfonate 3-phosphate (enterobacterial α glutathione molybdate putrescine glutamate M-antigen a microcin a maltodextrin oligopeptide oligopeptide -undecaprenyl phosphonate N-(4- an L-sorbose 1-phosphate N-acetyl- -D-galactosamine 1-phosphate an L-sorbose 1-phosphate an L-sorbose 1-phosphate 6-phosphate an L- arsenite 1-phosphate 1-phosphate 1-phosphate putrescine a branched- cadaverine phosphate phosphate 6'-phosphate 2-dehydro- L-tartrate 3-(3- common antigen) a basic α sn-glycerol monomer α phosphate a peptide aminobenzoyl) D-trehalose maltose 6'- a C4- D-fructose 1-phosphate D-fructose 1-phosphate D-fructose 1-phosphate D-fructose 1-phosphate sorbose 1- a lipopolysaccharide a lipopolysaccharide glutamate ornithine chain D-glucose D-glucose 6- D-glucose 6- lys lys a sugar 6- a sugar 6- a sugar 6- asp 3-deoxy-D- -L- an aromatic hydroxyphenyl) a D- a lyso- a purine -D- L-homoserine serine serine serine serine thr -undecaprenyl a macrolide homoserine D-fructose N-acetyl-α-D- amino acid a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside antimonite a nucleotide a nucleotide a nucleotide L-arabinose D-glucose (S)-lactate putrescine putrescine D-gluconate D-gluconate D-gluconate melibiose succinate 3-phenylpropanoate 3-phosphate undecaprenyl a carbohydrate pyrimidine a phospholipid a sulfonate a dicarboxylate antibiotic -L-glutamate microcin J25 6-phosphate phosphate 2-nitroimidazole dicarboxylate D-mannose 6-phosphate D-mannose 6-phosphate D-mannose 6-phosphate D-mannose 6-phosphate predicted phosphate amino acid predicted D-galactose phosphate phosphate phosphate phosphate phosphate gluconate arabinopyranose carboxylate propanoate glucoronoside phospholipid ribonucleoside xylopyranose thr thr thr thr thr diphosphate lactone glucosamine predicted predicted a polysaccharide a polysaccharide predicted predicted diphosphate PEP-driven predicted predicted ABC predicted predicted predicted predicted 4-amino-4-deoxy- predicted predicted predicted predicted predicted predicted PEP-driven ABC predicted predicted predicted predicted ABC ABC predicted predicted ABC transporter predicted ABC predicted ABC ABC ABC transporter ABC ABC ABC ABC L-arabinose- PEP-driven PEP-driven PEP-driven PEP-driven ABC ABC transporter transporter ABC PEP-driven PEP-driven PEP-driven transporter transporter ABC RS19155 RS24435 RS24440 RS03585 RS03710 RS27335 RS27525 RS21605 transporter of RS18775 RS27330 RS07390 RS14485 RS08215 RS25010 RS12655 RS11770 RS17660 RS20425 RS07820 RS21420 RS24620 RS08445 RS08460 RS04350 RS07360 RS11625 RS26280 RS03495 RS03500 of D- RS26275 RS01610 RS06255 RS13245 RS06200 efflux transporter of efflux transporter of RS00770 transporter RS13725 RS23875 RS01010 transporter RS20105 RS21485 of a RS08515 RS16665 RS07240 RS09645 RS14700 RS09390 RS17880 RS25565 RS08485 RS23590 RS00310 RS03490 transporter RS24670 RS02065 RS02200 RS25870 RS26880 RS25640 RS11215 RS08570 RS03840 RS06655 RS08095 RS21700 RS09470 RS14615 RS12680 RS05120 RS17760 RS03170 RS00450 RS18495 RS14255 transporter transporter of transporter RS01190 phosphoundecaprenol transporter transporter transporter transporter transporter transporter of N-acetyl- of D- transporter transporter transporter transporter of N,N'- of an of sn- transporter phosphonate mannose/ a lipopolysaccharide a lipopolysaccharide of L- of L-cysteine/ branched- of glutamate/ of maltose/a a tripeptide/an of an flippase of D-mannose of D-fructose of D-fructose of D-fructose of glutathione of molybdate alpha-D- galactose/a of putrescine of a sugar of a sugar diacetylchitobiose aliphatic glycerol 3- of a microcin D-fructose/ arabinose glutathione chain L-aspartate maltodextrin oligopeptide oligopeptide N-(4- L-sorbose N-acetyl-α-D-galactosamine L-sorbose N-acetyl-α-D-galactosamine a branched- galactosamine D-glucose methyl group 2-dehydro- α-L- sulfonate phosphate 3-(3- a D- α-D- a peptide D-fructose trehalose maltose α a C4- a basic L-sorbose L-sorbose L-arabinose D-glucose amino acid D-glucose D-glucose a sugar a sugar a sugar D-gluconate D-gluconate D-gluconate melibiose an aromatic sn-glycerol a carbohydrate a lyso- pyrimidine (enterobacterial a macrolide homoserine aminobenzoyl) N-acetyl- -D- a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside a nucleoside D-fructose D-fructose D-fructose L-sorbose a nucleotide glutamate (S)-lactate chain D-galactose putrescine putrescine lys 3-deoxy-D- arabinopyranose 3-phenylpropanoate hydroxyphenyl) M-antigen glucoronoside a phospholipid a sulfonate a dicarboxylate xylopyranose L-homoserine serine serine serine serine antibiotic microcin J25 2-nitroimidazole dicarboxylate amino acid antimonite a nucleotide a nucleotide a polysaccharide a polysaccharide N,N'- carboxylate succinate 3-phosphate phospholipid thr common antigen) phosphonate lactone -L-glutamate glucosamine D-mannose D-mannose D-mannose D-fructose D-mannose D-fructose D-fructose D-fructose ornithine amino acid lys a sugar a sugar asp gluconate propanoate monomer a purine maltose 4-amino-4- thr thr thr thr thr a lipopolysaccharide a lipopolysaccharide glutathione molybdate α putrescine diacetylchitobiose a microcin an an -undecaprenyl D-mannose arsenite L-arabinose cys putrescine N-acetyl- -D- methyl cadaverine glutamate glutamate an aliphatic L-tartrate sn-glycerol undecaprenyl ribonucleoside a maltodextrin deoxy-α-L- L-sorbose guanine guanine a branched- oligopeptide oligopeptide diphosphate glutathione galactosamine D-galactose asp sulfonate 3-phosphate diphosphate arabinopyranosyl D-fructose chain ditrans,octacis D-mannose amino acid -undecaprenyl phosphate This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.