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Home , CCDC186, Eukaryotic translation, Nucleoporin 50, SAAL1

Table S7. Fast evolving (FEGs) identified in glyptosternoid and yellowhead catfish lineages.

Corrected Lineage ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000006266 stat1a signal transduction and activation of 1a 0.001721806 0.024407355 G. maculatum ENSDARG00000000542 gtf2e1 general IIE, polypeptide 1, alpha 0.000023597 0.000811335 G. maculatum ENSDARG00000001578 echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 0.00036297 0.008500863 G. maculatum ENSDARG00000041022 pdcd4b programmed cell death 4b 0.000000005 2.13E-07 G. maculatum ENSDARG00000007385 cct7 chaperonin containing TCP1, subunit 7 (eta) 0.001056443 0.018161829 G. maculatum ENSDARG00000011488 sirt2 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) 0.00029034 0.007331085 G. maculatum ENSDARG00000011510 rcc2 regulator of condensation 2 0.000796136 0.014617937 G. maculatum ENSDARG00000008032 sart3 squamous cell carcinoma recognised by T cells 3 0.000206028 0.005549021 G. maculatum ENSDARG00000004581 sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.002482116 0.030854611 G. maculatum ENSDARG00000015343 pgd phosphogluconate hydrogenase 0.002819885 0.033029658 G. maculatum ENSDARG00000016484 dkc1 dyskeratosis congenita 1, dyskerin 0.003469896 0.036890473 G. maculatum ENSDARG00000007477 fbxo8 F-box 8 0.001265581 0.021084319 G. maculatum ENSDARG00000012947 SKA2 spindle and kinetochore associated complex subunit 2 0 0 G. maculatum ENSDARG00000015851 pnn pinin, desmosome associated protein 0.001318057 0.0214348 G. maculatum ENSDARG00000006926 btd biotinidase 0.00073626 0.013834839 G. maculatum ENSDARG00000018681 saal1 -like 1 0.002577249 0.031509023 G. maculatum ENSDARG00000011146 uqcrb ubiquinol-cytochrome c reductase binding protein 0.004070529 0.040537557 G. maculatum ENSDARG00000016754 tbca tubulin cofactor a 0.000147047 0.004400518 G. maculatum ENSDARG00000019547 aaas achalasia, adrenocortical insufficiency, alacrimia 0.002234427 0.029119629 G. maculatum ENSDARG00000020679 clpp ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) 0.001206936 0.020316756 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000005210 coro2a coronin, binding protein, 2A 0.002436008 0.030754601 G. maculatum ENSDARG00000012899 ddx49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 0.000229766 0.006086916 G. maculatum ENSDARG00000010312 cp ceruloplasmin 0.003769125 0.039044269 G. maculatum ENSDARG00000008237 sars seryl-tRNA synthetase 0.003291941 0.035230309 G. maculatum ENSDARG00000017407 ttll12 tubulin tyrosine ligase-like family, member 12 0.003845119 0.039455724 G. maculatum ENSDARG00000017454 nup50 50 0.004568658 0.043686103 G. maculatum ENSDARG00000012777 nucks1b nuclear casein kinase and cyclin-dependent kinase substrate 1b 0.00015587 0.004579744 G. maculatum ENSDARG00000089880 sf3b3 splicing factor 3b, subunit 3 0.003087821 0.033577808 G. maculatum ENSDARG00000017046 wbp11 WW domain binding protein 11 0.000959739 0.016858024 G. maculatum ENSDARG00000029011 xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.002084363 0.027609267 G. maculatum ENSDARG00000004046 phf6 PHD finger protein 6 0.002298562 0.02947997 G. maculatum ENSDARG00000016516 rbm8a RNA binding motif protein 8A 0.002654712 0.032015034 G. maculatum ENSDARG00000014472 eukaryotic 4A, isoform 3 0.003040787 0.033577808 G. maculatum ENSDARG00000016889 eukaryotic translation initiation factor 3, subunit G 0.000035711 0.001177734 G. maculatum ENSDARG00000008292 eukaryotic translation initiation factor 2, subunit 3 gamma 0.000041642 0.001345869 G. maculatum ENSDARG00000003938 rpa1 replication protein A1 0.001553725 0.02324833 G. maculatum ENSDARG00000022675 otud6b OTU domain containing 6B 0.003060036 0.033577808 G. maculatum ENSDARG00000027899 shfm1 split hand/foot malformation (ectrodactyly) type 1 0.003116752 0.033577808 G. maculatum ENSDARG00000019877 rbks ribokinase 0.002061806 0.027609267 G. maculatum ENSDARG00000024818 rilpl2 Rab interacting lysosomal protein-like 2 0.000677485 0.013366015 G. maculatum ENSDARG00000026039 cyp1a cytochrome P450, family 1, subfamily A 0.000052094 0.001650665 G. maculatum ENSDARG00000021555 park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin 0.002261937 0.029242322 G. maculatum ENSDARG00000026892 gpatch11 G patch domain containing 11 0.000804661 0.014617937 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000028517 hbp1 HMG-box transcription factor 1 0.000163761 0.004725675 G. maculatum ENSDARG00000032353 tiprl TIP41, TOR signaling pathway regulator-like (S. cerevisiae) 0.001501471 0.022676422 G. maculatum ENSDARG00000006766 snd1 staphylococcal nuclease domain containing 1 0.000063177 0.001963347 G. maculatum ENSDARG00000034916 hat1 histone acetyltransferase 1 0.005427046 0.04927026 G. maculatum ENSDARG00000023583 coq9 coenzyme Q9 homolog (S. cerevisiae) 0.000122608 0.003738387 G. maculatum ENSDARG00000031098 timm50 translocase of inner mitochondrial membrane 50 homolog (yeast) 0.001439112 0.022361586 G. maculatum ENSDARG00000030789 ddx18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.000007626 0.000280082 G. maculatum ENSDARG00000014727 acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.000000015 6.06E-07 G. maculatum ENSDARG00000035264 riok2 RIO kinase 2 (yeast) 0.001962692 0.026878901 G. maculatum ENSDARG00000035427 surf6 surfeit 6 0.000002224 8.56E-05 G. maculatum ENSDARG00000035730 utp6 UTP6, small subunit (SSU) processome component, homolog (yeast) 0.003082966 0.033577808 G. maculatum ENSDARG00000036438 ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.002687116 0.032165774 G. maculatum ENSDARG00000038027 nol12 nucleolar protein 12 0.005002734 0.046953506 G. maculatum ENSDARG00000039134 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.000987917 0.017166386 G. maculatum ENSDARG00000040584 n6amt2 N-6 adenine-specific DNA methyltransferase 2 (putative) 0.001640073 0.023454495 G. maculatum ENSDARG00000041237 med18 mediator of RNA polymerase II transcription, subunit 18 homolog (yeast) 0.003587273 0.037400214 G. maculatum ENSDARG00000041570 mitochondrial L39 0.0003211 0.007862085 G. maculatum ENSDARG00000041908 usp39 specific peptidase 39 0.00292275 0.033261718 G. maculatum ENSDARG00000042147 rbbp5 retinoblastoma binding protein 5 0.000894998 0.015893591 G. maculatum ENSDARG00000042962 dgcr2 DiGeorge syndrome critical region gene 2 0.000461038 0.009933832 G. maculatum ENSDARG00000043105 qtrt1 queuine tRNA-ribosyltransferase 1 0.002798837 0.033029658 G. maculatum ENSDARG00000043457 gapdh glyceraldehyde-3-phosphate dehydrogenase 0.002401312 0.030555277 G. maculatum ENSDARG00000006666 BUD13 BUD13 homolog (S. cerevisiae) 0.002593255 0.031509023 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000044811 cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.004208614 0.04121891 G. maculatum ENSDARG00000045399 cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.002081082 0.027609267 G. maculatum ENSDARG00000045486 pawr PRKC, apoptosis, WT1, regulator 0.004545094 0.043686103 G. maculatum ENSDARG00000045928 psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.001363893 0.021608344 G. maculatum ENSDARG00000052247 alkbh4 alkB, alkylation repair homolog 4 (E. coli) 0.00355679 0.037323199 G. maculatum ENSDARG00000060494 eprs glutamyl-prolyl-tRNA synthetase 0.005146172 0.047521223 G. maculatum ENSDARG00000054191 pgk1 phosphoglycerate kinase 1 0.004090383 0.040537557 G. maculatum ENSDARG00000055472 nubp1 nucleotide binding protein 1 (MinD homolog, E. coli) 0.001849741 0.025548559 G. maculatum ENSDARG00000055562 mtpn myotrophin 0.001598867 0.023454495 G. maculatum ENSDARG00000056102 uxs1 UDP-glucuronic acid decarboxylase 1 0.001339675 0.0214348 G. maculatum ENSDARG00000056517 thoc3 THO complex 3 0.005288298 0.048281862 G. maculatum ENSDARG00000057021 vps36 vacuolar protein sorting 36 homolog (S. cerevisiae) 0.001496204 0.022676422 G. maculatum ENSDARG00000057727 fut11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.005026582 0.046953506 G. maculatum ENSDARG00000058005 hgd homogentisate 1,2-dioxygenase 0.001482593 0.022676422 G. maculatum ENSDARG00000057882 arpc3 actin related protein 2/3 complex, subunit 3 0.00411396 0.040537557 G. maculatum ENSDARG00000057805 mitochondrial ribosomal protein L28 0.004030129 0.040537557 G. maculatum ENSDARG00000058297 timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.000350615 0.008332262 G. maculatum ENSDARG00000058467 prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.001749149 0.024579346 G. maculatum ENSDARG00000059459 C5H2orf68 chromosome 2 open 68 0.000300013 0.007458785 G. maculatum ENSDARG00000059701 flii flightless I homolog (Drosophila) 0.000876024 0.015729498 asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate G. maculatum ENSDARG00000061235 alg5 0.000006091 0.000228908 beta-glucosyltransferase) G. maculatum ENSDARG00000061372 cog7 component of oligomeric golgi complex 7 0.005479159 0.04946548 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000061789 gnl1 guanine nucleotide binding protein-like 1 0.000449565 0.009933832 G. maculatum ENSDARG00000062511 golga3 golgi autoantigen, golgin subfamily a, 3 0.000539019 0.011312399 G. maculatum ENSDARG00000067613 dnajc25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.000245421 0.006295243 G. maculatum ENSDARG00000075690 ddrgk1 DDRGK domain containing 1 0.002820602 0.033029658 G. maculatum ENSDARG00000068289 eukaryotic translation initiation factor 3, subunit K 0.000000008 3.31E-07 G. maculatum ENSDARG00000068886 mrpl14 mitochondrial ribosomal protein L14 0.003103837 0.033577808 G. maculatum ENSDARG00000069092 xrn2 5'-3' exoribonuclease 2 0.00038249 0.008830055 G. maculatum ENSDARG00000069113 dbn1 drebrin 1 0.000729884 0.013834839 G. maculatum ENSDARG00000019231 spna2 spectrin alpha 2 0.000344782 0.008315936 G. maculatum ENSDARG00000031388 dctn2 dynactin 2 (p50) 0.003028315 0.033577808 G. maculatum ENSDARG00000070403 wdyhv1 WDYHV motif containing 1 0.0005788 0.01169176 G. maculatum ENSDARG00000040713 rbbp9 retinoblastoma binding protein 9 0.001770372 0.024663113 G. maculatum ENSDARG00000037358 polr3e polymerase (RNA) III (DNA directed) polypeptide E 0.000720084 0.013834839 G. maculatum ENSDARG00000075570 ide insulin-degrading enzyme 0.001338732 0.0214348 G. maculatum ENSDARG00000076066 6-Mar membrane-associated ring finger (C3HC4) 6 0.000026009 0.000875636 G. maculatum ENSDARG00000034178 cpsf1 cleavage and specific factor 1 0.002916019 0.033261718 G. maculatum ENSDARG00000074312 coa3 cytochrome C oxidase assembly factor 3 0.005241891 0.04813009 G. maculatum ENSDARG00000076350 C2CD5 (1 of 2) C2 calcium-dependent domain containing 5 0.000549491 0.011384326 G. maculatum ENSDARG00000012820 nop56 NOP56 ribonucleoprotein homolog 0.002857043 0.033215694 G. maculatum ENSDARG00000017842 syvn1 synovial apoptosis inhibitor 1, synoviolin 0.002469477 0.030854611 G. maculatum ENSDARG00000089260 dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.001299704 0.021431854 G. maculatum ENSDARG00000004906 stip1 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) 0.001638184 0.023454495 G. maculatum ENSDARG00000007901 crnkl1 crooked neck pre-mRNA splicing factor-like 1 (Drosophila) 0.004518246 0.043686103 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000078381 trip11 thyroid hormone receptor interactor 11 0.000000023 9.07E-07 G. maculatum ENSDARG00000077782 ACER2 alkaline ceramidase 2 0.001635107 0.023454495 G. maculatum ENSDARG00000075446 naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.000243801 0.006295243 G. maculatum ENSDARG00000061114 BX927294.1 Uncharacterized protein 0.002180126 0.028642956 G. maculatum ENSDARG00000076815 eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.000175375 0.00488631 G. maculatum ENSDARG00000059600 rabep1 rabaptin, RAB GTPase binding effector protein 1 0.00255262 0.031488809 C22H10orf76 (1 G. maculatum ENSDARG00000030790 open reading frame 76 0.000678226 0.013366015 of 2) G. maculatum ENSDARG00000075025 cdc123 cell division cycle 123 homolog (S. cerevisiae) 0.001130901 0.019237221 G. maculatum ENSDARG00000075192 yme1l1a YME1-like 1a 0.000203339 0.005549021 G. maculatum ENSDARG00000059919 C3H16orf58 chromosome 16 open reading frame 58 0.000457214 0.009933832 G. maculatum ENSDARG00000089106 ddb1 damage specific DNA binding protein 1 0.000565366 0.011564955 holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase G. maculatum ENSDARG00000039934 hlcs 0.004712899 0.044800263 (ATP-hydrolysing)) ligase) G. maculatum ENSDARG00000037965 srrm2 serine/ repetitive matrix 2 0.000172594 0.00488631 G. maculatum ENSDARG00000052377 psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.000007923 0.000284524 G. maculatum ENSDARG00000069373 crcp calcitonin gene-related peptide-receptor component protein 0.001995855 0.027103375 G. maculatum ENSDARG00000086618 psma3 proteasome (prosome, macropain) subunit, alpha type, 3 0.000728174 0.013834839 G. maculatum ENSDARG00000044820 cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.001415604 0.022209865 G. maculatum ENSDARG00000037930 rnf113a ring finger protein 113A 0.004389287 0.042729445 G. maculatum ENSDARG00000008947 rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.003083879 0.033577808 G. maculatum ENSDARG00000079949 supt16h suppressor of Ty 16 homolog (S. cerevisiae) 0.000397598 0.008923866 G. maculatum ENSDARG00000003846 mrpl21 mitochondrial ribosomal protein L21 0.002898478 0.033261718 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000020820 srp68 signal recognition particle 68 0.003857676 0.039455724 G. maculatum ENSDARG00000051800 fnbp4 formin binding protein 4 0.00051539 0.010958819 G. maculatum ENSDARG00000092285 cenpv protein V 0.003550821 0.037323199 G. maculatum ENSDARG00000038870 slu7 SLU7 splicing factor homolog (S. cerevisiae) 0.000395927 0.008923866 G. maculatum ENSDARG00000039338 gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0 0 G. maculatum ENSDARG00000012389 adar adenosine deaminase, RNA-specific 0.000805072 0.014617937 G. maculatum ENSDARG00000028379 trub2 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 0 0 G. maculatum ENSDARG00000074624 si:ch211-198a12.6 si:ch211-198a12.6 0 0 G. maculatum ENSDARG00000035136 sepw1 selenoprotein W, 1 0 0 G. maculatum ENSDARG00000044365 angptl3 angiopoietin-like 3 0.003987646 0.040528528 G. maculatum ENSDARG00000059634 thumpd3 THUMP domain containing 3 0 0 G. maculatum ENSDARG00000053571 adob 2-aminoethanethiol (cysteamine) dioxygenase b 0 0 G. maculatum ENSDARG00000095623 dpm2 dolichol-phosphate (beta-D) mannosyltransferase 2 0 0 G. maculatum ENSDARG00000059388 bdh1 3-hydroxybutyrate dehydrogenase, type 1 0.004085937 0.040537557 G. maculatum ENSDARG00000032037 bet1l blocked early in transport 1 homolog (S. cerevisiae)-like 0 0 G. maculatum ENSDARG00000075842 pigt phosphatidylinositol glycan anchor , class T 0 0 G. maculatum ENSDARG00000052271 slc22a18 solute carrier family 22 (organic cation transporter), member 18 0 0 G. maculatum ENSDARG00000038566 gnptg N-acetylglucosamine-1-phosphate transferase, gamma subunit 0 0 G. maculatum ENSDARG00000000779 sly1 suppressor of ypt1 0 0 G. maculatum ENSDARG00000076618 tm2d3 TM2 domain containing 3 0 0 G. maculatum ENSDARG00000019976 idi1 isopentenyl-diphosphate delta isomerase 1 0 0 G. maculatum ENSDARG00000039649 mtif3 mitochondrial translational initiation factor 3 0.00000993 0.000348845 G. maculatum ENSDARG00000045562 pus1 pseudouridine synthase 1 0 0 Corrected Lineage Gene ID Gene name Gene description P-value P-value G. maculatum ENSDARG00000092473 apopt1 apoptogenic 1, mitochondrial 0 0 G. maculatum ENSDARG00000042933 bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0 0 G. maculatum ENSDARG00000057928 mzt2b mitotic spindle organizing protein 2B 0 0 G. maculatum ENSDARG00000002690 rabif RAB interacting factor 0 0 G. maculatum ENSDARG00000033973 mrps23 mitochondrial ribosomal protein S23 0 0 G. maculatum ENSDARG00000043342 gpx3 glutathione peroxidase 3 (plasma) 0 0 G. maculatum ENSDARG00000070798 pmvk phosphomevalonate kinase 0 0 G. maculatum ENSDARG00000036650 cdadc1 cytidine and dCMP deaminase domain containing 1 0 0 G. maculatum ENSDARG00000042851 srp9 signal recognition particle 9 0 0 G. maculatum ENSDARG00000019406 C7H11orf68 open reading frame 68 0.00159557 0.023454495 P. sinensis ENSDARG00000020218 amfr autocrine motility factor receptor 0.000135769 0.002990638

P. sinensis ENSDARG00000011553 atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 0.002643736 0.027967944

P. sinensis ENSDARG00000007385 cct7 chaperonin containing TCP1, subunit 7 (eta) 0.001223233 0.015735669

P. sinensis ENSDARG00000001788 atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.001307777 0.01655831

P. sinensis ENSDARG00000011488 sirt2 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) 0.000619334 0.009136597

P. sinensis ENSDARG00000008243 cct8 chaperonin containing TCP1, subunit 8 (theta) 0.000327427 0.005372476

P. sinensis ENSDARG00000003035 hspa9 heat shock protein 9 0.004937815 0.043152209

P. sinensis ENSDARG00000021107 sf3a2 splicing factor 3a, subunit 2 0.001027006 0.013536276

P. sinensis ENSDARG00000016173 cct3 chaperonin containing TCP1, subunit 3 (gamma) 0.000726974 0.01043727

P. sinensis ENSDARG00000008502 pno1 partner of NOB1 homolog (S. cerevisiae) 0.001717365 0.020041684

P. sinensis ENSDARG00000020608 sgut1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.000122675 0.002858861 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000018049 sf3b2 splicing factor 3b, subunit 2 0.00001388 0.000444628

P. sinensis ENSDARG00000020344 slc2a8 solute carrier family 2 (facilitated glucose transporter), member 8 0.002712469 0.028507517

P. sinensis ENSDARG00000016484 dkc1 dyskeratosis congenita 1, dyskerin 0.000000137 5.37E-06

P. sinensis ENSDARG00000016864 farsb phenylalanyl-tRNA synthetase, beta subunit 0.000519276 0.008106755

P. sinensis ENSDARG00000007216 ATP-binding cassette, sub-family E (OABP), member 1 0.000074811 0.001879626

P. sinensis ENSDARG00000009436 ubxn7 UBX domain protein 7 0.000266137 0.004976143

P. sinensis ENSDARG00000009449 PDCL3 phosducin-like 3 0.005198465 0.045178014

P. sinensis ENSDARG00000015352 lsg1 large subunit GTPase 1 homolog (S. cerevisiae) 0.005225815 0.045178014

P. sinensis ENSDARG00000015676 nmd3 NMD3 homolog (S. cerevisiae) 0.003567836 0.035414076

P. sinensis ENSDARG00000015221 nsrp1 nuclear speckle splicing regulatory protein 1 0.000941357 0.012699944

P. sinensis ENSDARG00000005273 ergic1 -golgi intermediate compartment (ERGIC) 1 0.00140144 0.01760559

P. sinensis ENSDARG00000002710 ncl nucleolin 0.000548709 0.008246019

P. sinensis ENSDARG00000014692 znf622 zinc finger protein 622 0.003792055 0.036512721

P. sinensis ENSDARG00000075325 mrpl16 mitochondrial ribosomal protein L16 0.0042004 0.038465094

P. sinensis ENSDARG00000014139 srp72 signal recognition particle 72 0.004918592 0.043152209

P. sinensis ENSDARG00000052462 pisd phosphatidylserine decarboxylase 0.002791452 0.028959063

P. sinensis ENSDARG00000015889 zc3h15 zinc finger CCCH-type containing 15 0.000000009 3.91E-07

P. sinensis ENSDARG00000012777 nucks1b nuclear casein kinase and cyclin-dependent kinase substrate 1b 0.000198895 0.00399779

P. sinensis ENSDARG00000018491 pdia4 protein disulfide isomerase associated 4 0.000017708 0.000547586 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000021398 mul1a mitochondrial E3 ubiquitin ligase 1a 0.000067379 0.001747507

P. sinensis ENSDARG00000003584 pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.001682117 0.01988856

P. sinensis ENSDARG00000002215 rtca RNA 3'-terminal phosphate cyclase 0.001732459 0.020041684

P. sinensis ENSDARG00000007169 itgb1bp1 integrin beta 1 binding protein 1 0.002438082 0.026489431

P. sinensis ENSDARG00000014031 abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.000260318 0.004924604

P. sinensis ENSDARG00000016415 dhtkd1 dehydrogenase E1 and transketolase domain containing 1 0.000000217 8.31E-06

P. sinensis ENSDARG00000014506 tmem126a transmembrane protein 126A 0.003219474 0.033185347

P. sinensis ENSDARG00000014472 eif4a3 eukaryotic translation initiation factor 4A, isoform 3 0.001452115 0.01805079

P. sinensis ENSDARG00000016889 eif3g eukaryotic translation initiation factor 3, subunit G 0.002177209 0.024197583 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac P. sinensis ENSDARG00000010149 atp5a1 0.000153897 0.003299552 muscle P. sinensis ENSDARG00000003938 rpa1 replication protein A1 0.000947757 0.012699944

P. sinensis ENSDARG00000024381 msto1 misato homolog 1 (Drosophila) 0.000032309 0.000911454

P. sinensis ENSDARG00000022675 otud6b OTU domain containing 6B 0.001778752 0.020430237

P. sinensis ENSDARG00000021753 ccdc25 coiled-coil domain containing 25 0.000863465 0.011969411

P. sinensis ENSDARG00000009754 zc3h11a zinc finger CCCH-type containing 11A 0.004116191 0.038259163

P. sinensis ENSDARG00000023852 lsm4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.000147104 0.00319653

P. sinensis ENSDARG00000022232 ppan peter pan homolog (Drosophila) 0.000227077 0.004399275

P. sinensis ENSDARG00000032564 ass1 argininosuccinate synthetase 1 0.002133821 0.023994295

P. sinensis ENSDARG00000034823 copg2 coatomer protein complex, subunit gamma 2 0.001195903 0.015508161 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000075380 kri1 KRI1 homolog 0.000169682 0.003590114

P. sinensis ENSDARG00000038743 copb2 coatomer protein complex, subunit beta 2 0.004107745 0.038259163

P. sinensis ENSDARG00000007421 ftcd formiminotransferase cyclodeaminase 0.003930961 0.03740228

P. sinensis ENSDARG00000035264 riok2 RIO kinase 2 (yeast) 0.00032154 0.005330271

P. sinensis ENSDARG00000036482 hexim1 hexamethylene bis-acetamide inducible 1 0.002055922 0.023281145

P. sinensis ENSDARG00000037570 polr1d polymerase (RNA) I polypeptide D 0.001295521 0.016533316

P. sinensis ENSDARG00000004726 trappc11 trafficking protein particle complex 11 0.000315118 0.005278227

P. sinensis ENSDARG00000037909 C3H19orf52 chromosome 19 open reading frame 52 0.000110425 0.0026502

P. sinensis ENSDARG00000038297 aspdh aspartate dehydrogenase domain containing 0.002394643 0.026194462

P. sinensis ENSDARG00000038360 thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 0.0016197 0.0194364

P. sinensis ENSDARG00000040072 scpep1 serine carboxypeptidase 1 0.005552258 0.047489526

P. sinensis ENSDARG00000040245 kpnb3 karyopherin () beta 3 0.000207263 0.004114554

P. sinensis ENSDARG00000040730 wdr75 WD repeat domain 75 0.000304117 0.005278227

P. sinensis ENSDARG00000041223 fam173a family with sequence similarity 173, member A 0.00067381 0.009761139

P. sinensis ENSDARG00000041340 MRPL51 mitochondrial ribosomal protein L51 0.000190313 0.003925576

P. sinensis ENSDARG00000058257 slc39a1 solute carrier family 39 (zinc transporter), member 1 0.000210722 0.004132207

P. sinensis ENSDARG00000042517 mitochondrial ribosomal protein S24 0.00473396 0.041986435

P. sinensis ENSDARG00000043635 cmc2 COX assembly mitochondrial protein 2 homolog (S. cerevisiae) 0.000875876 0.01203768

P. sinensis ENSDARG00000017864 txnrd1 thioredoxin reductase 1 0.00145933 0.01805079 Corrected Lineage Gene ID Gene name Gene description P-value P-value ribosomal RNA processing 9, small subunit (SSU) processome component, homolog P. sinensis ENSDARG00000041991 rrp9 0.000133193 0.002976319 (yeast) P. sinensis ENSDARG00000069525 gpn3 GPN-loop GTPase 3 0.000532757 0.008237243

P. sinensis ENSDARG00000044809 fpgs folylpolyglutamate synthase 0.004752196 0.041986435

P. sinensis ENSDARG00000045399 cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.000003317 0.000113484

P. sinensis ENSDARG00000045827 lyrm5b LYR motif containing 5b 0.003611535 0.035627904

P. sinensis ENSDARG00000051888 ist1 increased sodium tolerance 1 homolog (yeast) 0.000001516 5.30E-05

P. sinensis ENSDARG00000052819 tmem203 transmembrane protein 203 0.000845328 0.011819891

P. sinensis ENSDARG00000053225 gnl2 guanine nucleotide binding protein-like 2 (nucleolar) 0.000129812 0.002976319

P. sinensis ENSDARG00000060494 eprs glutamyl-prolyl-tRNA synthetase 0.001560151 0.019005476

P. sinensis ENSDARG00000070261 crlf3 cytokine receptor-like factor 3 0.004257952 0.038465094

P. sinensis ENSDARG00000054259 nat10 N-acetyltransferase 10 0.002029513 0.023145084

P. sinensis ENSDARG00000055445 SLC22A15 solute carrier family 22, member 15 0.005505965 0.04734541

P. sinensis ENSDARG00000055477 pelo pelota homolog (Drosophila) 0.000800301 0.011288456

P. sinensis ENSDARG00000056138 sf3b1 splicing factor 3b, subunit 1 0.000003884 0.000130114

P. sinensis ENSDARG00000056903 mrpl13 mitochondrial ribosomal protein L13 0.000438749 0.006985232

P. sinensis ENSDARG00000001940 dnajc1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.000133268 0.002976319

P. sinensis ENSDARG00000057414 phb prohibitin 0.000000546 1.95E-05

P. sinensis ENSDARG00000057435 c1qtnf3 C1q and related protein 3 0.000313134 0.005278227

P. sinensis ENSDARG00000059079 vps25 vacuolar protein sorting 25 (yeast) 0.002181996 0.024197583 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000059323 rpn1 ribophorin I 0.005627075 0.047874797

P. sinensis ENSDARG00000059701 flii flightless I homolog (Drosophila) 0.000019695 0.000586473

P. sinensis ENSDARG00000059866 cactin cactin 0.000270065 0.004991546

P. sinensis ENSDARG00000059902 vps16 vacuolar protein sorting protein 16 0.001127949 0.01474587

P. sinensis ENSDARG00000060489 mitochondrial ribosomal protein L32 0.003968457 0.037536934

P. sinensis ENSDARG00000061020 CCDC186 coiled-coil domain containing 186 0.000031393 0.000901428

P. sinensis ENSDARG00000061231 tinagl1 tubulointerstitial nephritis antigen-like 1 0.000770668 0.010966674

P. sinensis ENSDARG00000061789 gnl1 guanine nucleotide binding protein-like 1 0.000067056 0.001747507

P. sinensis ENSDARG00000062083 dph7 diphthamide biosynthesis 7 0.004215184 0.038465094

P. sinensis ENSDARG00000063147 ptdss2 phosphatidylserine synthase 2 0.000453344 0.007146835

P. sinensis ENSDARG00000063252 prcc papillary renal cell carcinoma (translocation-associated) 0.000938423 0.012699944

P. sinensis ENSDARG00000067607 srebf1 sterol regulatory element binding transcription factor 1 0.000544993 0.008246019

P. sinensis ENSDARG00000063686 xrcc6bp1 XRCC6 binding protein 1 0.004067767 0.038251283

P. sinensis ENSDARG00000077830 loh12cr1 loss of heterozygosity, 12, chromosomal region 1 homolog () 0.003815252 0.036517412

P. sinensis ENSDARG00000067838 C20H14orf169 chromosome 14 open reading frame 169 0.000368781 0.005929998

P. sinensis ENSDARG00000067944 actr8 ARP8 actin-related protein 8 homolog (yeast) 0.00424756 0.038465094

P. sinensis ENSDARG00000045017 pdrg1 p53 and DNA-damage regulated 1 0.000626855 0.00916348

P. sinensis ENSDARG00000068187 spg7 spastic paraplegia 7 0.000004424 0.000145179

P. sinensis ENSDARG00000068289 eif3k eukaryotic translation initiation factor 3, subunit K 0.000000414 1.51E-05 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000074703 CCDC97 coiled-coil domain containing 97 0.000354153 0.005752303

P. sinensis ENSDARG00000069092 xrn2 5'-3' exoribonuclease 2 0.000121199 0.002858861

P. sinensis ENSDARG00000039346 ndufa5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.000539647 0.008246019

P. sinensis ENSDARG00000057255 emc1 ER membrane protein complex subunit 1 0.001721304 0.020041684

P. sinensis ENSDARG00000040747 tm4sf4 transmembrane 4 L six family member 4 0.00029406 0.005253872

P. sinensis ENSDARG00000031198 hmg20a high-mobility group 20A 0.000560807 0.008349793

P. sinensis ENSDARG00000071087 slc35b4 solute carrier family 35, member B4 0.003678455 0.035637087

P. sinensis ENSDARG00000076761 ftsj FtsJ homolog 3 (E. coli) 0.002259124 0.024881311

P. sinensis ENSDARG00000002663 optn optineurin 0.003637211 0.035637087

P. sinensis ENSDARG00000040111 pi4kb phosphatidylinositol 4-kinase, catalytic, beta 0.000102455 0.002496176 MAP3K14 (2 of P. sinensis ENSDARG00000074060 mitogen-activated protein kinase kinase kinase 14 0.000046783 0.001297018 2) P. sinensis ENSDARG00000004906 stip1 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) 0.00163847 0.019515998

P. sinensis ENSDARG00000007901 crnkl1 crooked neck pre-mRNA splicing factor-like 1 (Drosophila) 0.000000018 7.62E-07

P. sinensis ENSDARG00000078381 trip11 thyroid hormone receptor interactor 11 0.00004862 0.001325101

P. sinensis ENSDARG00000078008 ATG7 autophagy related 7 0.002616183 0.02785975

P. sinensis ENSDARG00000003384 akap17a A kinase (PRKA) anchor protein 17A 0.000000096 3.86E-06

P. sinensis ENSDARG00000008224 vps35 vacuolar protein sorting 35 (yeast) 0.000000027 1.11E-06

P. sinensis ENSDARG00000069338 zgc:152863 zgc:152863 0.000309724 0.005278227

P. sinensis ENSDARG00000076815 eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.000025802 0.000754357 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000063069 gripap1 GRIP1 associated protein 1 0.00352664 0.035222591 C22H10orf76 (1 P. sinensis ENSDARG00000030790 chromosome 10 open reading frame 76 0.001597782 0.019317545 of 2) P. sinensis ENSDARG00000075192 yme1l1a YME1-like 1a 0.000071352 0.001821175

P. sinensis ENSDARG00000017891 tcp1 t-complex polypeptide 1 0.000192861 0.003925576

P. sinensis ENSDARG00000016345 ncoa5 nuclear receptor coactivator 5 0.00001909 0.000579183

P. sinensis ENSDARG00000029215 ube2z ubiquitin-conjugating enzyme E2Z 0.001525626 0.018726768

P. sinensis ENSDARG00000040238 pank4 pantothenate kinase 4 0.003458994 0.034900052

P. sinensis ENSDARG00000022682 add1 adducin 1 (alpha) 0.000240198 0.004598076

P. sinensis ENSDARG00000008480 trmt61a tRNA methyltransferase 61 homolog A (S. cerevisiae) 0.003678953 0.035637087

P. sinensis ENSDARG00000090219 wdr45 WD repeat domain 45 0.005699849 0.048238722

P. sinensis ENSDARG00000086100 CABZ01055500.1 Uncharacterized protein 0.00258861 0.02785975

P. sinensis ENSDARG00000008947 rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.000066445 0.001747507

P. sinensis ENSDARG00000059622 ubfd1 ubiquitin family domain containing 1 0.000304557 0.005278227

P. sinensis ENSDARG00000025766 DTX3 deltex 3, E3 ubiquitin ligase 0.004362605 0.039190329

P. sinensis ENSDARG00000079949 supt16h suppressor of Ty 16 homolog (S. cerevisiae) 0.004240284 0.038465094

P. sinensis ENSDARG00000044167 padi2 peptidyl arginine deiminase, type II 0.000279378 0.005104998

P. sinensis ENSDARG00000020820 srp68 signal recognition particle 68 0.003261758 0.03340705

P. sinensis ENSDARG00000043970 lrpprc leucine-rich PPR-motif containing 0.000000355 1.33E-05

P. sinensis ENSDARG00000040650 gps1 G protein pathway suppressor 1 0.000308676 0.005278227 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000021242 mvp major vault protein 0.00019111 0.003925576

P. sinensis ENSDARG00000038870 slu7 SLU7 splicing factor homolog (S. cerevisiae) 0.000078567 0.001943627

P. sinensis ENSDARG00000044380 rbmx2 RNA binding motif protein, X-linked 2 0.001009135 0.013410654

P. sinensis ENSDARG00000062374 leng9 leukocyte receptor cluster (LRC) member 9 0.002605736 0.02785975

P. sinensis ENSDARG00000039338 gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0 0

P. sinensis ENSDARG00000012389 adar adenosine deaminase, RNA-specific 0.004508207 0.040273316

P. sinensis ENSDARG00000028379 trub2 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 0 0

P. sinensis ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0 0

P. sinensis ENSDARG00000074624 si:ch211-198a12.6 si:ch211-198a12.6 0 0

P. sinensis ENSDARG00000035136 sepw1 selenoprotein W, 1 0 0

P. sinensis ENSDARG00000039208 nasp nuclear autoantigenic sperm protein (histone-binding) 0 0

P. sinensis ENSDARG00000059634 thumpd3 THUMP domain containing 3 0 0

P. sinensis ENSDARG00000031985 ppp2r4 protein phosphatase 2A activator, regulatory subunit 4 0 0

P. sinensis ENSDARG00000053571 adob 2-aminoethanethiol (cysteamine) dioxygenase b 0 0

P. sinensis ENSDARG00000078773 tmem70 transmembrane protein 70 0.003472642 0.034900052

P. sinensis ENSDARG00000013434 hira HIR histone cell cycle regulation defective homolog A (S. cerevisiae) 0 0

P. sinensis ENSDARG00000095623 dpm2 dolichol-phosphate (beta-D) mannosyltransferase 2 0 0

P. sinensis ENSDARG00000004925 immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0 0

P. sinensis ENSDARG00000092836 jmy junction mediating and regulatory protein, p53 cofactor 0.002784928 0.028959063 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. sinensis ENSDARG00000032037 bet1l blocked early in transport 1 homolog (S. cerevisiae)-like 0 0

P. sinensis ENSDARG00000075842 pigt phosphatidylinositol glycan anchor biosynthesis, class T 0 0

P. sinensis ENSDARG00000052271 slc22a18 solute carrier family 22 (organic cation transporter), member 18 0 0

P. sinensis ENSDARG00000025094 edem1 ER degradation enhancer, mannosidase alpha-like 1 0 0

P. sinensis ENSDARG00000038566 gnptg N-acetylglucosamine-1-phosphate transferase, gamma subunit 0 0

P. sinensis ENSDARG00000000779 sly1 suppressor of ypt1 0 0

P. sinensis ENSDARG00000092954 mrpl34 mitochondrial ribosomal protein L34 0 0

P. sinensis ENSDARG00000052738 hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0 0

P. sinensis ENSDARG00000076618 tm2d3 TM2 domain containing 3 0 0

P. sinensis ENSDARG00000092473 apopt1 apoptogenic 1, mitochondrial 0 0

P. sinensis ENSDARG00000042933 bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0 0

P. sinensis ENSDARG00000033973 mrps23 mitochondrial ribosomal protein S23 0 0

P. sinensis ENSDARG00000043342 gpx3 glutathione peroxidase 3 (plasma) 0 0

P. sinensis ENSDARG00000036650 cdadc1 cytidine and dCMP deaminase domain containing 1 0 0

P. sinensis ENSDARG00000004343 nelfe negative complex member E 0.003312642 0.03371347 P. macrotrema ENSDARG00000020218 amfr autocrine motility factor receptor 0.00000001 4.38E-07 P. macrotrema ENSDARG00000008551 pole3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.000142092 0.003838852 P. macrotrema ENSDARG00000016173 cct3 chaperonin containing TCP1, subunit 3 (gamma) 0.002474962 0.03458546 P. macrotrema ENSDARG00000009470 hnf1a HNF1 homeobox a 0.000906913 0.016760845 P. macrotrema ENSDARG00000016307 mrpl46 mitochondrial ribosomal protein L46 0.002411897 0.033997261 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000016484 dkc1 dyskeratosis congenita 1, dyskerin 0.000258974 0.006559326 P. macrotrema ENSDARG00000016864 farsb phenylalanyl-tRNA synthetase, beta subunit 0.000927704 0.016896721 P. macrotrema ENSDARG00000008953 pofut1 protein O-fucosyltransferase 1 0.003514236 0.043485317 P. macrotrema ENSDARG00000018903 aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.000512361 0.010647913 P. macrotrema ENSDARG00000014138 acot8 acyl-CoA thioesterase 8 0.001563046 0.026120593 P. macrotrema ENSDARG00000015851 pnn pinin, desmosome associated protein 0.002593533 0.035368885 P. macrotrema ENSDARG00000021439 ncoa4 nuclear receptor coactivator 4 0.000059157 0.00195701 P. macrotrema ENSDARG00000016080 nob1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.000460364 0.00985408 P. macrotrema ENSDARG00000075325 mrpl16 mitochondrial ribosomal protein L16 0.000268618 0.00669892 P. macrotrema ENSDARG00000013961 slc31a1 solute carrier family 31 (copper transporters), member 1 0.001013883 0.018060487 P. macrotrema ENSDARG00000013965 cul2 cullin 2 0.000344052 0.008082729 P. macrotrema ENSDARG00000008395 snupn snurportin 1 0.000590665 0.012119848 P. macrotrema ENSDARG00000011693 ttc36 tetratricopeptide repeat domain 36 0.002351757 0.033440334 P. macrotrema ENSDARG00000017658 gmppb GDP-mannose pyrophosphorylase B 0.001365646 0.023302233 dihydrolipoamide S-acetyltransferase (E2 component of P. macrotrema ENSDARG00000015918 dlat 0.000172046 0.004571911 complex) P. macrotrema ENSDARG00000009160 kmo kynurenine 3-monooxygenase 0.002674411 0.035828266 P. macrotrema ENSDARG00000019496 esd esterase D/formylglutathione hydrolase 0.001937606 0.029082031 P. macrotrema ENSDARG00000014031 abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.000508122 0.010647913 P. macrotrema ENSDARG00000009740 ppp1r7 protein phosphatase 1, regulatory (inhibitor) subunit 7 0.000225073 0.005791164 P. macrotrema ENSDARG00000016415 dhtkd1 dehydrogenase E1 and transketolase domain containing 1 0.000067995 0.002135979 P. macrotrema ENSDARG00000020448 adi1 acireductone dioxygenase 1 0.003357446 0.042501024 P. macrotrema ENSDARG00000007603 stxbp2 syntaxin binding protein 2 0.000060653 0.00196637 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000028614 mospd1 motile sperm domain containing 1 0.003487693 0.043485317 P. macrotrema ENSDARG00000026767 nol11 nucleolar protein 11 0.000070197 0.002146969 P. macrotrema ENSDARG00000024116 vamp8 vesicle-associated membrane protein 8 (endobrevin) 0.000710353 0.014042466 P. macrotrema ENSDARG00000021853 ntpcr nucleoside-triphosphatase, cancer-related 0.003107124 0.039973397 P. macrotrema ENSDARG00000022232 ppan peter pan homolog (Drosophila) 0.000725663 0.014172286 P. macrotrema ENSDARG00000031439 glrx3 glutaredoxin 3 0.00252101 0.034927839 P. macrotrema ENSDARG00000032769 slc38a9 solute carrier family 38, member 9 0.001897885 0.029082031 P. macrotrema ENSDARG00000032985 mrpl27 mitochondrial ribosomal protein L27 0.000335637 0.008000994 P. macrotrema ENSDARG00000075380 kri1 KRI1 homolog 0.000082424 0.00238588 P. macrotrema ENSDARG00000013058 ascc2 activating signal cointegrator 1 complex subunit 2 0.003268119 0.04171355 P. macrotrema ENSDARG00000033754 rbm48 RNA binding motif protein 48 0.001239841 0.021380662 P. macrotrema ENSDARG00000035332 C10H21orf59 chromosome 21 open reading frame 59 0.00121138 0.021114484 P. macrotrema ENSDARG00000035570 C5H9orf85 chromosome 9 open reading frame 85 0.000001133 4.27E-05 P. macrotrema ENSDARG00000036704 tmem18 transmembrane protein 18 0.001935986 0.029082031 P. macrotrema ENSDARG00000038281 NATD1 N-acetyltransferase domain containing 1 0.000846794 0.01614886 P. macrotrema ENSDARG00000038865 acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.004051491 0.04937945 P. macrotrema ENSDARG00000040853 shoc2 soc-2 suppressor of clear homolog (C. elegans) 0.001932064 0.029082031 P. macrotrema ENSDARG00000041237 med18 mediator of RNA polymerase II transcription, subunit 18 homolog (yeast) 0.000056972 0.001923992 P. macrotrema ENSDARG00000041362 chmp7 CHMP family, member 7 0.000000139 5.63E-06 P. macrotrema ENSDARG00000041575 trmt10c tRNA methyltransferase 10 homolog C (S. cerevisiae) 0.000104576 0.002873181 P. macrotrema ENSDARG00000075768 sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.001893118 0.029082031 P. macrotrema ENSDARG00000042658 acad8 acyl-Coenzyme A dehydrogenase family, member 8 0.002596482 0.035368885 P. macrotrema ENSDARG00000042780 apoba apolipoprotein Ba 0.001721742 0.028191351 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000043105 qtrt1 queuine tRNA-ribosyltransferase 1 0.001869005 0.029082031 P. macrotrema ENSDARG00000043359 rmnd5b required for meiotic nuclear division 5 homolog B (S. cerevisiae) 0.002001744 0.029769055 P. macrotrema ENSDARG00000006666 BUD13 BUD13 homolog (S. cerevisiae) 0.000075289 0.002260064 P. macrotrema ENSDARG00000045249 nif3l1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 0.00000045 1.74E-05 P. macrotrema ENSDARG00000045364 trappc3 trafficking protein particle complex 3 0.002637429 0.03562727 P. macrotrema ENSDARG00000045691 zcrb1 zinc finger CCHC-type and RNA binding motif 1 0.000426077 0.009461244 P. macrotrema ENSDARG00000060494 eprs glutamyl-prolyl-tRNA synthetase 0.000000091 3.78E-06 P. macrotrema ENSDARG00000055524 rnf7 ring finger protein 7 0.003008804 0.039332833 P. macrotrema ENSDARG00000055743 ankrd54 ankyrin repeat domain 54 0.000620798 0.012578919 P. macrotrema ENSDARG00000057435 c1qtnf3 C1q and tumor necrosis factor related protein 3 0.000094911 0.002699136 P. macrotrema ENSDARG00000058306 prpf18 PRP18 pre-mRNA processing factor 18 homolog (yeast) 0.002049927 0.029936321 P. macrotrema ENSDARG00000070097 vimp VCP-interacting membrane protein 0.00174566 0.028297149 P. macrotrema ENSDARG00000060380 coq6 coenzyme Q6 homolog, monooxygenase (S. cerevisiae) 0.000302199 0.007311412 P. macrotrema ENSDARG00000060922 dgcr14 DiGeorge syndrome critical region gene 14 0.000000049 2.09E-06 P. macrotrema ENSDARG00000061020 CCDC186 coiled-coil domain containing 186 0.000909904 0.016760845 P. macrotrema ENSDARG00000061186 itga4 integrin alpha 4 0.000410791 0.009248503 P. macrotrema ENSDARG00000061201 acsf2 acyl-CoA synthetase family member 2 0.000640396 0.012815826 P. macrotrema ENSDARG00000061505 mrps9 mitochondrial ribosomal protein S9 0.000449507 0.009846633 P. macrotrema ENSDARG00000062834 ecsit ECSIT homolog (Drosophila) 0.000078545 0.002314935 P. macrotrema ENSDARG00000063627 bop1 block of proliferation 1 0.001821896 0.029082031 P. macrotrema ENSDARG00000068289 eif3k eukaryotic translation initiation factor 3, subunit K 0.000003736 0.000137638 P. macrotrema ENSDARG00000045207 camlg calcium modulating ligand 0.000000212 8.38E-06 P. macrotrema ENSDARG00000013670 hyou1 hypoxia up-regulated 1 0.001612686 0.026675143 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000069242 pdia5 protein disulfide isomerase family A, member 5 0.000833445 0.016083504 P. macrotrema ENSDARG00000069313 oxa1l oxidase (cytochrome c) assembly 1-like 0.002204217 0.031902105 P. macrotrema ENSDARG00000017423 patl1 protein associated with II homolog 1 (yeast) 0.002026198 0.029858791 P. macrotrema ENSDARG00000070061 gfer growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) 0.003382253 0.042501024 P. macrotrema ENSDARG00000040747 tm4sf4 transmembrane 4 L six family member 4 0.003763237 0.046213691 P. macrotrema ENSDARG00000076559 RB1CC1 RB1-inducible coiled-coil 1 0.001100797 0.019395565 P. macrotrema ENSDARG00000011299 blzf1 basic leucine zipper nuclear factor 1 0.000391057 0.008928217 P. macrotrema ENSDARG00000077614 C13H6orf203 chromosome 6 open reading frame 203 0.000462005 0.00985408 P. macrotrema ENSDARG00000078381 trip11 thyroid hormone receptor interactor 11 0.000036547 0.001260483 P. macrotrema ENSDARG00000014817 ranbp1 RAN binding protein 1 0.000176494 0.004614464 P. macrotrema ENSDARG00000003384 akap17a A kinase (PRKA) anchor protein 17A 0.000008697 0.000313285 P. macrotrema ENSDARG00000076815 eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.001435371 0.024236837 P. macrotrema ENSDARG00000079881 TCAIM T cell activation inhibitor, mitochondrial 0.00006852 0.002135979 P. macrotrema ENSDARG00000073786 cmbl carboxymethylenebutenolidase-like (Pseudomonas) 0.002957779 0.038980161 P. macrotrema ENSDARG00000091831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.001877255 0.029082031 P. macrotrema ENSDARG00000087729 SMIM20 small integral membrane protein 20 0.000874829 0.016489509 P. macrotrema ENSDARG00000027009 zgc:85777 zgc:85777 0.000973733 0.017538013 P. macrotrema ENSDARG00000089937 dio3a deiodinase, iodothyronine, type IIIa 0.00309565 0.039973397 P. macrotrema ENSDARG00000003941 rrs1 RRS1 biogenesis regulator homolog (S. cerevisiae) 0.000104067 0.002873181 P. macrotrema ENSDARG00000034060 elac2 elaC homolog 2 (E. coli) 0.00292622 0.038880349 P. macrotrema ENSDARG00000043970 lrpprc leucine-rich PPR-motif containing 0.000359793 0.008331778 P. macrotrema ENSDARG00000039338 gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0 0 P. macrotrema ENSDARG00000028379 trub2 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 0 0 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0 0 P. macrotrema ENSDARG00000005799 smim14 small integral membrane protein 14 0 0 P. macrotrema ENSDARG00000035136 sepw1 selenoprotein W, 1 0 0 P. macrotrema ENSDARG00000039208 nasp nuclear autoantigenic sperm protein (histone-binding) 0 0 P. macrotrema ENSDARG00000059634 thumpd3 THUMP domain containing 3 0 0 P. macrotrema ENSDARG00000031985 ppp2r4 protein phosphatase 2A activator, regulatory subunit 4 0 0 P. macrotrema ENSDARG00000013434 hira HIR histone cell cycle regulation defective homolog A (S. cerevisiae) 0 0 P. macrotrema ENSDARG00000095623 dpm2 dolichol-phosphate (beta-D) mannosyltransferase 2 0 0 P. macrotrema ENSDARG00000004925 immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0 0 P. macrotrema ENSDARG00000032037 bet1l blocked early in transport 1 homolog (S. cerevisiae)-like 0 0 P. macrotrema ENSDARG00000075842 pigt phosphatidylinositol glycan anchor biosynthesis, class T 0 0 P. macrotrema ENSDARG00000052271 slc22a18 solute carrier family 22 (organic cation transporter), member 18 0 0 P. macrotrema ENSDARG00000025094 edem1 ER degradation enhancer, mannosidase alpha-like 1 0 0 P. macrotrema ENSDARG00000038566 gnptg N-acetylglucosamine-1-phosphate transferase, gamma subunit 0 0 P. macrotrema ENSDARG00000052738 hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0 0 P. macrotrema ENSDARG00000076618 tm2d3 TM2 domain containing 3 0 0 P. macrotrema ENSDARG00000039649 mtif3 mitochondrial translational initiation factor 3 0.000012951 0.000456382 P. macrotrema ENSDARG00000045562 pus1 pseudouridine synthase 1 0 0 P. macrotrema ENSDARG00000057928 mzt2b mitotic spindle organizing protein 2B 0 0 P. macrotrema ENSDARG00000033973 mrps23 mitochondrial ribosomal protein S23 0 0 P. macrotrema ENSDARG00000043342 gpx3 glutathione peroxidase 3 (plasma) 0 0 P. macrotrema ENSDARG00000005230 ssr2 signal sequence receptor, beta 0 0 P. macrotrema ENSDARG00000070798 pmvk phosphomevalonate kinase 0 0 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. macrotrema ENSDARG00000036650 cdadc1 cytidine and dCMP deaminase domain containing 1 0 0 P. macrotrema ENSDARG00000058597 nt5c3a 5'-nucleotidase, cytosolic IIIA 0 0 P. fulvidraco ENSDARG00000020218 amfr autocrine motility factor receptor 0.001108919 0.027235723 P. fulvidraco ENSDARG00000007385 cct7 chaperonin containing TCP1, subunit 7 (eta) 0.000050289 0.001988255 P. fulvidraco ENSDARG00000016484 dkc1 dyskeratosis congenita 1, dyskerin 0.001959838 0.044123575 P. fulvidraco ENSDARG00000007955 iars isoleucyl-tRNA synthetase 0.00011033 0.003974332 P. fulvidraco ENSDARG00000005210 coro2a coronin, actin binding protein, 2A 0.000258908 0.008393797 P. fulvidraco ENSDARG00000017454 nup50 nucleoporin 50 0.000254656 0.008393797 P. fulvidraco ENSDARG00000004727 cmss1 cms1 ribosomal small subunit homolog (yeast) 0.000870604 0.023043326 P. fulvidraco ENSDARG00000016867 rnf128a ring finger protein 128a 0.002312777 0.048680812 P. fulvidraco ENSDARG00000004527 pin4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) 0.000710445 0.019855713 P. fulvidraco ENSDARG00000014031 abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.000088309 0.003253384 P. fulvidraco ENSDARG00000021555 park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin 0.002476036 0.049963743 P. fulvidraco ENSDARG00000054224 IPO11 importin 11 0.002435335 0.049963743 P. fulvidraco ENSDARG00000002830 trmt2a trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.002496646 0.049963743 P. fulvidraco ENSDARG00000033855 rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.000296613 0.009427641 P. fulvidraco ENSDARG00000035763 CABZ01086801.1 Uncharacterized protein 0.000025985 0.001053042 P. fulvidraco ENSDARG00000037906 alkbh7 alkB, alkylation repair homolog 7 (E. coli) 0.001012644 0.025253783 P. fulvidraco ENSDARG00000038207 aldh4a1 aldehyde dehydrogenase 4 family, member A1 0.00079218 0.021502781 P. fulvidraco ENSDARG00000042458 rfc4 replication factor C (activator 1) 4 0.001238664 0.029968274 P. fulvidraco ENSDARG00000042780 apoba apolipoprotein Ba 0.000051942 0.002004714 P. fulvidraco ENSDARG00000043336 exosc7 exosome component 7 0.002342445 0.048680812 P. fulvidraco ENSDARG00000043542 znf259 zinc finger protein 259 0.00171466 0.039147378 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. fulvidraco ENSDARG00000027310 LSP1 lymphocyte-specific protein 1 0.00007237 0.002728181 P. fulvidraco ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 0.000922705 0.023370388 P. fulvidraco ENSDARG00000056099 gtf2h5 general transcription factor IIH, polypeptide 5 0.000215713 0.007284808 P. fulvidraco ENSDARG00000059866 cactin cactin 0.002178934 0.047730433 P. fulvidraco ENSDARG00000063572 perp PERP, TP53 apoptosis effector 0.00232001 0.048680812 P. fulvidraco ENSDARG00000056605 wbp2 WW domain binding protein 2 0.000004394 0.000187439 P. fulvidraco ENSDARG00000070029 ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.000198157 0.006834308 P. fulvidraco ENSDARG00000076761 ftsj FtsJ homolog 3 (E. coli) 0.000381082 0.011439517 P. fulvidraco ENSDARG00000003527 mak16 MAK16 homolog (S. cerevisiae) 0.001708812 0.039147378 P. fulvidraco ENSDARG00000015653 tnip1 TNFAIP3 interacting protein 1 0.001678137 0.039147378 P. fulvidraco ENSDARG00000075936 sugp1 SURP and G patch domain containing 1 0.000313794 0.009781925 P. fulvidraco ENSDARG00000078418 meaf6 MYST/Esa1-associated factor 6 0.002000584 0.044423927 P. fulvidraco ENSDARG00000074028 ZNFX1 zinc finger, NFX1-type containing 1 0.001497608 0.035700332 P. fulvidraco ENSDARG00000008560 brap BRCA1 associated protein 0.000916579 0.023370388 P. fulvidraco ENSDARG00000044567 ttc1 tetratricopeptide repeat domain 1 0.002300153 0.048680812 P. fulvidraco ENSDARG00000037935 aldh16a1 aldehyde dehydrogenase 16 family, member A1 0.000795908 0.021502781 P. fulvidraco ENSDARG00000028379 trub2 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 0 0 P. fulvidraco ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0 0 P. fulvidraco ENSDARG00000093188 si:dkey-75a21.2 si:dkey-75a21.2 0.000159251 0.005611867 P. fulvidraco ENSDARG00000005799 smim14 small integral membrane protein 14 0 0 P. fulvidraco ENSDARG00000031985 ppp2r4 protein phosphatase 2A activator, regulatory subunit 4 0 0 P. fulvidraco ENSDARG00000053571 adob 2-aminoethanethiol (cysteamine) dioxygenase b 0 0 P. fulvidraco ENSDARG00000095623 dpm2 dolichol-phosphate (beta-D) mannosyltransferase 2 0 0 Corrected Lineage Gene ID Gene name Gene description P-value P-value P. fulvidraco ENSDARG00000004925 immp2l IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0 0 P. fulvidraco ENSDARG00000032037 bet1l blocked early in transport 1 homolog (S. cerevisiae)-like 0 0 P. fulvidraco ENSDARG00000075842 pigt phosphatidylinositol glycan anchor biosynthesis, class T 0 0 P. fulvidraco ENSDARG00000052271 slc22a18 solute carrier family 22 (organic cation transporter), member 18 0 0 P. fulvidraco ENSDARG00000025094 edem1 ER degradation enhancer, mannosidase alpha-like 1 0 0 P. fulvidraco ENSDARG00000000779 sly1 suppressor of ypt1 0 0 P. fulvidraco ENSDARG00000092954 mrpl34 mitochondrial ribosomal protein L34 0 0 P. fulvidraco ENSDARG00000052738 hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0 0 P. fulvidraco ENSDARG00000076618 tm2d3 TM2 domain containing 3 0 0 P. fulvidraco ENSDARG00000019976 idi1 isopentenyl-diphosphate delta isomerase 1 0 0 P. fulvidraco ENSDARG00000039649 mtif3 mitochondrial translational initiation factor 3 0.000012426 0.000516476 P. fulvidraco ENSDARG00000045562 pus1 pseudouridine synthase 1 0 0 P. fulvidraco ENSDARG00000092473 apopt1 apoptogenic 1, mitochondrial 0 0 P. fulvidraco ENSDARG00000042933 bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0 0 P. fulvidraco ENSDARG00000057928 mzt2b mitotic spindle organizing protein 2B 0 0 P. fulvidraco ENSDARG00000043342 gpx3 glutathione peroxidase 3 (plasma) 0 0 P. fulvidraco ENSDARG00000005230 ssr2 signal sequence receptor, beta 0 0 P. fulvidraco ENSDARG00000042851 srp9 signal recognition particle 9 0 0 P. fulvidraco ENSDARG00000058597 nt5c3a 5'-nucleotidase, cytosolic IIIA 0 0