Report of Genemania Search

GeneMANIA http://www.genemania.org/print

Created on: 5 December 2012 00:06:51 Last database update: 19 July 2012 20:00:00 Application version: 3.1.1

Report of GeneMANIA search

Network image

POLR3H TAF1B

POLR1B

TAF1C POLR2L

POLR2F

RFWD2

0.33 Functions legend Networks legend transcription from RNA polymerase I promoter Co-expression query genes Co-localization Genetic interactions Pathway Physical interactions Predicted Shared protein domains

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Search parameters

Organism: H. sapiens (human)

Genes: TCOF1; TP53; POLR1C; POLR1D

Networks: Attributes:

Network weighting: Automatically selected weighting method (Biological process based)

Number of gene results: 20

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Networks

Co-expression 37.73 % Wang-Maris-2006 2.68 % Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Wang et al. (2006). Cancer Res . Source: Pearson correlation with 231,830 interactions from GEO Tags: transcription factors; cancer

Ramaswamy-Golub-2001 2.44 % Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al. (2001). Proc Natl Acad Sci U S A. Source: Pearson correlation with 226,615 interactions from supplementary material Tags: cancer

Radtke-Downing-2009 2.33 % Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Radtke et al. (2009). Proc Natl Acad Sci U S A . Source: Pearson correlation with 377,767 interactions from GEO Tags: transcription factors; nervous system; cancer

Gobble-Singer-2011 2.15 % Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Gobble et al. (2011). Cancer Res . Source: Pearson correlation with 449,507 interactions from GEO Tags: apoptosis; cell line; cultured cells; cancer; transcription factors

Kang-Willman-2010 2.04 % Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Kang et al. (2010). Blood . Source: Pearson correlation with 549,783 interactions from GEO Tags: transcription factors; lymphoma; cancer

Hummel-Siebert-2006 2.00 % A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. Hummel et al. (2006). N Engl J Med . Source: Pearson correlation with 466,765 interactions from GEO Tags: cancer

Jones-Libermann-2005 1.99 % Gene signatures of progression and metastasis in renal cell cancer. Jones et al. (2005). Clin Cancer Res . Source: Pearson correlation with 365,428 interactions from GEO Tags: transcription factors; disease; cancer

Bild-Nevins-2006 B 1.96 % Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al. (2006). Nature . Note: One of 3 datasets produced from this publication. Source: Pearson correlation with 254,105 interactions from GEO Tags: cultured cells; signal transduction; cancer; epithelial cells; cell line; disease; breast; transcription factors; breast cancer

Noble-Diehl-2008 1.92 % Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Noble et al. (2008). Gut . Source: Pearson correlation with 603,016 interactions from GEO

Wu-Garvey-2007 1.89 % The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Wu et al. (2007).

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Endocrine . Source: Pearson correlation with 223,988 interactions from GEO Tags: transcription factors; muscle; cultured cells

Nakayama-Hasegawa-2007 1.89 % Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Nakayama et al. (2007). Mod Pathol . Source: Pearson correlation with 361,398 interactions from GEO Tags: transcription factors; cancer

Burington-Shaughnessy-2008 1.88 % Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Burington et al. (2008). Clin Cancer Res . Source: Pearson correlation with 266,464 interactions from GEO Tags: transcription factors; time series; cancer; chemotherapy

Burczynski-Dorner-2006 1.77 % Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Burczynski et al. (2006). J Mol Diagn . Source: Pearson correlation with 419,356 interactions from GEO

Raue-Trappe-2012 1.72 % Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. Raue et al. (2012). J Appl Physiol . Source: Pearson correlation with 483,849 interactions from GEO

Rieger-Chu-2004 1.72 % Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al. (2004). Proc Natl Acad Sci U S A . Source: Pearson correlation with 220,846 interactions from GEO Tags: cultured cells; cell line

Arijs-Rutgeerts-2009 1.58 % Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs et al. (2009). PLoS One . Source: Pearson correlation with 570,210 interactions from GEO Tags: immune system

Peng-Katze-2009 1.54 % Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al. (2009). BMC Genomics . Source: Pearson correlation with 349,954 interactions from GEO Tags: liver

Berchtold-Cotman-2008 1.53 % Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold et al. (2008). Proc Natl Acad Sci U S A . Source: Pearson correlation with 507,933 interactions from GEO Tags: aging; brain

Toedter-Baribaud-2011 1.49 % Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis. Toedter et al. (2011). Am J Gastroenterol . Source: Pearson correlation with 572,082 interactions from GEO Tags: signal transduction; immune system

Perou-Botstein-1999 1.18 % Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al. (1999). Proc Natl Acad Sci U S A .

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Source: Pearson correlation with 50,804 interactions from supplementary material Tags: cultured cells; cancer; epithelial cells; signal transduction; breast; stromal cells; transcription factors; breast cancer

Physical interactions 32.73 % Behzadnia-Lührmann-2007 8.91 % Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia et al. (2007). EMBO J . Source: Direct interaction with 101 interactions from iRefIndex

Kneissl-Grummt-2003 5.94 % Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl et al. (2003). J Mol Biol . Source: Direct interaction with 83 interactions from iRefIndex Tags: cell proliferation; transcription factors; cultured cells; cell line

McFarland-Nussbaum-2008 4.19 % Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland et al. (2008). Mol Cell Proteomics . Source: Direct interaction with 152 interactions from iRefIndex Tags: brain; nervous system

Hutchins-Peters-2010 3.22 % Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al. (2010). Science . Source: Direct interaction with 141 interactions from iRefIndex Tags: cell proliferation; nervous system; localization

Jeronimo-Coulombe-2007 2.10 % Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo et al. (2007). Mol Cell . Source: Direct interaction with 660 interactions from iRefIndex Tags: cultured cells; cell line

Ramachandran-LaBaer-2004 1.26 % Self-assembling protein microarrays. Ramachandran et al. (2004). Science . Source: Direct interaction with 119 interactions from iRefIndex

Goudreault-Gingras-2009 1.13 % A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault et al. (2009). Mol Cell Proteomics . Source: Direct interaction with 242 interactions from iRefIndex Tags: nervous system

Sato-Conaway-2004 1.05 % A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato et al. (2004). Mol Cell . Source: Direct interaction with 235 interactions from iRefIndex Tags: transcription factors

Barr-Knapp-2009 0.75 % Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr et al. (2009). Cell . Source: Direct interaction with 177 interactions from iRefIndex

IREF-MPPI 0.52 % Source: Direct interaction with 385 interactions from iRefIndex

Jones-MacBeath-2006 0.47 % A quantitative protein interaction network for the ErbB receptors using protein microarrays. Jones et al. (2006). Nature .

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Source: Direct interaction with 139 interactions from iRefIndex Tags: cultured cells; cell line

Sowa-Harper-2009 A 0.42 % Defining the human deubiquitinating enzyme interaction landscape. Sowa et al. (2009). Cell . Note: One of 2 datasets produced from this publication. Source: Direct interaction with 1,511 interactions from BioGRID

IREF-SMALL-SCALE-STUDIES 0.40 % Source: Direct interaction with 41,955 interactions from iRefIndex

Cannavo-Jiricny-2007 0.39 % Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. Cannavo et al. (2007). J Biol Chem . Source: Direct interaction with 109 interactions from iRefIndex Tags: transcription factors; cell line; cultured cells; cancer

BIOGRID-SMALL-SCALE-STUDIES 0.38 % Source: Direct interaction with 28,821 interactions from BioGRID

IREF-DIP 0.32 % Source: Direct interaction with 12,700 interactions from iRefIndex

IREF-BIND 0.32 % Source: Direct interaction with 5,310 interactions from iRefIndex

IREF-CORUM 0.20 % Source: Direct interaction with 637 interactions from iRefIndex

IREF-INTACT 0.17 % Source: Direct interaction with 21,448 interactions from iRefIndex

de Hoog-Mann-2004 0.15 % RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. de Hoog et al. (2004). Cell . Source: Direct interaction with 220 interactions from iRefIndex

Svendsen-Harper-2009 0.12 % Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen et al. (2009). Cell . Source: Direct interaction with 233 interactions from iRefIndex Tags: transcription factors; cultured cells; cell line

IREF-MINT 0.12 % Source: Direct interaction with 13,341 interactions from iRefIndex

Glatter-Gstaiger-2009 0.11 % An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Glatter et al. (2009). Mol Syst Biol . Source: Direct interaction with 307 interactions from iRefIndex Tags: cultured cells; cell line

Barrios-Rodiles-Wrana-2005 0.05 % High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles et al. (2005). Science . Source: Direct interaction with 547 interactions from iRefIndex Tags: cell signalling; cell line; cancer; epithelial cells; signal transduction; cultured cells; transcription factors

Predicted 16.14 % I2D-Chen-Pawson-2009-PiwiScreen-Mouse2Human 2.99 %

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Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Chen et al. (2009). Proc Natl Acad Sci U S A . Note: I2D predictions of protein protein interactions using Chen-Pawson-2009 Mus musculus data Source: Direct interaction with 30 interactions from I2D

I2D-Li-Vidal-2004-interolog-Worm2Human 2.68 % A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science . Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data Source: Direct interaction with 567 interactions from I2D

I2D-BioGRID-Yeast2Human 1.55 % BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using BioGRID Saccharomyces cerevisiae data Source: Direct interaction with 13,434 interactions from I2D

I2D-vonMering-Bork-2002-High-Yeast2Human 1.40 % Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature . Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data Source: Direct interaction with 1,196 interactions from I2D

I2D-Li-Vidal-2004-literature-Worm2Human 0.93 % A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science . Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data Source: Direct interaction with 15 interactions from I2D

I2D-vonMering-Bork-2002-Medium-Yeast2Human 0.82 % Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature . Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data Source: Direct interaction with 3,001 interactions from I2D

I2D-vonMering-Bork-2002-Low-Yeast2Human 0.76 % Comparative assessment of large-scale data sets of protein-protein interactions. von Mering et al. (2002). Nature . Note: I2D predictions of protein protein interactions using vonMering-Bork-2002 Saccharomyces cerevisiae data Source: Direct interaction with 16,074 interactions from I2D

Stuart-Kim-2003 0.63 % A gene-coexpression network for global discovery of conserved genetic modules. Stuart et al. (2003). Science . Source: 24,952 interactions from supplementary material Tags: cell proliferation; cultured cells; signal transduction; cancer

I2D-Yu-Vidal-2008-GoldStd-Yeast2Human 0.62 % High-quality binary protein interaction map of the yeast interactome network. Yu et al. (2008). Science . Note: I2D predictions of protein protein interactions using Yu Gold Standard Saccharomyces cerevisiae data Source: Direct interaction with 386 interactions from I2D Tags: transcription factors; signal transduction

I2D-IntAct-Rat2Human 0.58 % The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using IntAct Rattus norvegicus data Source: Direct interaction with 1,054 interactions from I2D

I2D-MINT-Mouse2Human 0.44 % MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett . Note: I2D predictions of protein protein interactions using MINT Mus musculus data Source: Direct interaction with 977 interactions from I2D

I2D-MINT-Rat2Human 0.44 %

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MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett . Note: I2D predictions of protein protein interactions using MINT Rattus norvegicus data Source: Direct interaction with 574 interactions from I2D

I2D-IntAct-Mouse2Human 0.41 % The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using IntAct Mus musculus data Source: Direct interaction with 3,422 interactions from I2D

I2D-BioGRID-Mouse2Human 0.35 % BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using BioGRID Mus musculus data Source: Direct interaction with 288 interactions from I2D

I2D-MGI-Mouse2Human 0.30 % Ontological visualization of protein-protein interactions. Drabkin et al. (2005). BMC Bioinformatics . Note: I2D predictions of protein protein interactions using MGI Mus musculus data Source: Direct interaction with 724 interactions from I2D

I2D-Li-Vidal-2004-CORE-1-Worm2Human 0.23 % A map of the interactome network of the metazoan C. elegans. Li et al. (2004). Science . Note: I2D predictions of protein protein interactions using Li-Vidal-2004 Caenorhabditis elegans data Source: Direct interaction with 103 interactions from I2D

I2D-IntAct-Fly2Human 0.22 % The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using IntAct Drosophila melanogaster data Source: Direct interaction with 3,920 interactions from I2D

I2D-BIND-Rat2Human 0.22 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Rattus norvegicus data Source: Direct interaction with 556 interactions from I2D

I2D-Tewari-Vidal-2004-TGFb-Worm2Human 0.15 % Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari et al. (2004). Mol Cell . Note: I2D predictions of protein protein interactions usingTewari-Vidal-2004 Caenorhabditis elegans data Source: Direct interaction with 18 interactions from I2D Tags: development; cultured cells; cell line; signal transduction; cell signalling; transcription factors; kidney

I2D-BIND-Yeast2Human 0.10 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Saccharomyces cerevisiae data Source: Direct interaction with 1,543 interactions from I2D

I2D-MINT-Worm2Human 0.08 % MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett . Note: I2D predictions of protein protein interactions using MINT Caenorhabditis elegans data Source: Direct interaction with 1,166 interactions from I2D

I2D-INNATEDB-Mouse2Human 0.07 % InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Lynn et al. (2008). Mol Syst Biol . Note: I2D predictions of protein protein interactions using INNATEDB Mus musculus data

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Source: Direct interaction with 1,455 interactions from I2D Tags: signal transduction; immune system

I2D-BIND-Worm2Human 0.07 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Caenorhabditis elegans data Source: Direct interaction with 911 interactions from I2D

I2D-Tarassov-PCA-Yeast2Human 0.04 % An in vivo map of the yeast protein interactome. Tarassov et al. (2008). Science . Note: I2D predictions of protein protein interactions using Tarassov-Michnick-2008 Saccharomyces cerevisiae data Source: Direct interaction with 441 interactions from I2D Tags: cell proliferation

I2D-Krogan-Greenblatt-2006-NonCore-Yeast2Human 0.03 % Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Krogan et al. (2006). Nature . Note: I2D predictions of protein protein interactions using Krogan-Greenblatt-2006 Saccharomyces cerevisiae data Source: Direct interaction with 1,794 interactions from I2D

I2D-BIND-Mouse2Human 0.02 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Mus musculus data Source: Direct interaction with 1,198 interactions from I2D

Pathway 6.73 % PATHWAYCOMMONS-HUMANCYC < 0.01 % Source: Direct interaction with 685 interactions from Pathway Commons

Wu-Stein-2010 3.13 % A human functional protein interaction network and its application to cancer data analysis. Wu et al. (2010). Genome Biol . Source: 78,448 interactions from supplementary material Tags: transcription factors; cancer

PATHWAYCOMMONS-REACTOME 2.20 % Source: Direct interaction with 24,924 interactions from Pathway Commons

PATHWAYCOMMONS-IMID 0.73 % Source: Direct interaction with 937 interactions from Pathway Commons

PATHWAYCOMMONS-NCI_NATURE 0.40 % Source: Direct interaction with 10,118 interactions from Pathway Commons

PATHWAYCOMMONS-CELL_MAP 0.26 % Source: Direct interaction with 598 interactions from Pathway Commons

Co-localization 5.32 % Johnson-Shoemaker-2003 3.01 % Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Johnson et al. (2003). Science . Source: Pearson correlation with 426,934 interactions from GEO Tags: cultured cells; cell line

Schadt-Shoemaker-2004 2.31 % A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al. (2004). Genome Biol . Note: Predicted transcript array

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Source: Pearson correlation with 60,454 interactions from GEO

Shared protein domains 0.98 % PFAM 0.73 % Source: Pearson correlation with 530,357 interactions from Pfam

INTERPRO 0.25 % Source: Pearson correlation with 488,822 interactions from InterPro

Genetic interactions 0.36 % IREF-SMALL-SCALE-STUDIES 0.21 % Source: Direct interaction with 171 interactions from iRefIndex

BIOGRID-SMALL-SCALE-STUDIES 0.16 % Source: Direct interaction with 345 interactions from BioGRID

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Attributes

Attribute Gene

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Genes

TCOF1 Treacher Collins-Franceschetti syndrome 1 [Source:HGNC Symbol;Acc:11654] Functions: 1

Synonyms: ENSG00000070814; ENSP00000325223; ENSP00000367028; ENSP00000377811; ENSP00000390717; ENSP00000400939; ENSP00000406888; ENSP00000409944; ENSP00000421655; ENSP00000422567; ENSP00000426471; ENSP00000426587; ENSP00000427484; 6949; TCOF1; NP_000347; NP_001008657; NP_001128715; NP_001128716; NP_001128717; NP_001182070; NM_000356; NM_001008656; NM_001008657; NM_001135243; NM_001135244; NM_001135245; NM_001195141; MFD1; treacle; Q13428; TCOF_HUMAN; More at Entrez

POLR1D polymerase (RNA) I polypeptide D, 16kDa [Source:HGNC Symbol;Acc:20422] Functions: 1 2 3 4 5 6 7 8 12 13 14

Synonyms: ENSG00000186184; ENSP00000302478; ENSP00000382603; ENSP00000382604; 51082; POLR1D; NP_001193488; NP_057056; NP_689918; NM_001206559; NM_015972; NM_152705; AC19; MGC9850; RPA16; RPA9; RPAC2; RPC16; RPO1-3; TCS2; Q9Y2S0; RPAC2_HUMAN; More at Entrez

POLR1C polymerase (RNA) I polypeptide C, 30kDa [Source:HGNC Symbol;Acc:20194] Functions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Synonyms: ENSG00000171453; ENSP00000307212; ENSP00000361419; ENSP00000361448; ENSP00000361465; ENSP00000395401; ENSP00000409536; ENSP00000423773; 9533; POLR1C; NP_976035; NM_004875; NM_203290; RPA39; RPA40; RPA5; RPAC1; TCS3; O15160; RPAC1_HUMAN; More at Entrez

TP53 tumor protein p53 [Source:HGNC Symbol;Acc:11998] Functions: 1 16 17 31

Synonyms: ENSG00000141510; ENSP00000269305; ENSP00000352610; ENSP00000379735; ENSP00000391127; ENSP00000391478; ENSP00000394195; ENSP00000398846; ENSP00000402130; ENSP00000410739; ENSP00000423862; ENSP00000424104; ENSP00000425104; ENSP00000426252; ENSP00000437792; 7157; TP53; NP_000537; NP_001119584; NP_001119585; NP_001119586; NP_001119587; NP_001119588; NP_001119589; NP_001119590; NM_000546; NM_001126112; NM_001126113; NM_001126114; NM_001126115; NM_001126116; NM_001126117; NM_001126118; LFS1; P53; TRP53; P04637; P53_HUMAN; More at Entrez

POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) [Source:HGNC Symbol;Acc:30349] Functions: 3 5 9 10 11 12 13 14 21 22 34

Synonyms: ENSG00000100413; ENSP00000337627; ENSP00000347345; ENSP00000379761; ENSP00000385315; ENSP00000395674; ENSP00000408083; ENSP00000415053; 171568; POLR3H; NP_001018060; NP_001018062; NP_612211; NM_001018050; NM_001018051; NM_001018052; NM_138338; KIAA1665; RPC22.9; RPC8; Q9Y535; RPC8_HUMAN; More at Entrez

ZNRD1 zinc ribbon domain containing 1 [Source:HGNC Symbol;Acc:13182] Functions:

Synonyms: ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176;

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ENSG00000235443; ENSG00000236808; ENSG00000236949; ENSP00000331111; ENSP00000352333; ENSP00000365978; ENSP00000365981; ENSP00000373108; ENSP00000383500; ENSP00000383501; ENSP00000383503; ENSP00000387914; ENSP00000391809; ENSP00000393236; ENSP00000394779; ENSP00000395065; ENSP00000395397; ENSP00000396661; ENSP00000396922; ENSP00000397636; ENSP00000399302; ENSP00000399966; ENSP00000402198; ENSP00000405264; ENSP00000405636; ENSP00000407364; ENSP00000407715; ENSP00000410127; ENSP00000410530; ENSP00000410954; ENSP00000412369; ENSP00000413265; ENSP00000414110; ENSP00000414720; ENSP00000416599; 30834; ZNRD1; NP_055411; NP_740753; NM_014596; NM_170783; HTEX-6; hZR14; Rpa12; tctex-6; TEX6; Q9P1U0; RPA12_HUMAN; More at Entrez

RFWD2 ring finger and WD repeat domain 2 [Source:HGNC Symbol;Acc:17440] Functions:

Synonyms: ENSG00000143207; ENSP00000310943; ENSP00000356637; ENSP00000356638; ENSP00000356639; ENSP00000356641; ENSP00000393956; ENSP00000433517; ENSP00000433810; ENSP00000437212; ENSP00000437275; 64326; RFWD2; NP_001001740; NP_071902; NM_001001740; NM_022457; FLJ10416; RNF200; Q8NHY2; RFWD2_HUMAN; More at Entrez

POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa [Source:HGNC Symbol;Acc:9189] Functions: 5 6 9 10 11 15 16 17 18 19 20 23 24 25 26 27 28 29 30 31 32 33 35

36 37 38

Synonyms: ENSG00000102978; ENSP00000219252; 5432; POLR2C; NP_116558; NM_002694; NM_032940; hRPB33; hsRPB3; RPB3; RPB31; P19387; RPB3_HUMAN; More at Entrez

POLR1A polymerase (RNA) I polypeptide A, 194kDa [Source:HGNC Symbol;Acc:17264] Functions: 2 3 4 5 6 7 8 9 10 11

Synonyms: ENSG00000068654; ENSP00000263857; ENSP00000386300; ENSP00000386423; ENSP00000397321; 25885; POLR1A; NP_056240; NM_015425; A190; DKFZP586M0122; FLJ21915; RPA194; RPO1-4; RPO14; O95602; RPA1_HUMAN; More at Entrez

POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa [Source:HGNC Symbol;Acc:9199] Functions: 2 3 5 6 9 10 11 12 13 14 15 16 17 18 19 20 23 24 25 26 27 28 29 30 31 32 33 35

36 37 38

Synonyms: ENSG00000177700; ENSP00000324124; ENSP00000432807; 5441; POLR2L; NP_066951; NM_021128; hRPB7.6; hsRPB10b; RBP10; RPABC5; RPB10; RPB10beta; RPB7.6; P62875; RPAB5_HUMAN; More at Entrez

POLR1B polymerase (RNA) I polypeptide B, 128kDa [Source:HGNC Symbol;Acc:20454] Functions: 2 3 4 5 6 7 8

Synonyms: ENSG00000125630; ENSP00000263331; ENSP00000334589; ENSP00000387143; ENSP00000388577; ENSP00000390274; ENSP00000390973; ENSP00000394408; ENSP00000403094; ENSP00000405358; ENSP00000415754; ENSP00000437914; ENSP00000441192; ENSP00000444136; 84172; POLR1B; NP_001131076; NP_061887; NM_001137604; NM_019014; FLJ10816; FLJ21921; RPA135; Rpo1-2; Q9H9Y6; RPA2_HUMAN; More at Entrez

POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa [Source:HGNC Symbol;Acc:15763] Functions: 3 5 9 10 11 12 13 14 21 22 34

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Synonyms: ENSG00000132664; ENSP00000366828; 10621; POLR3F; NP_006457; NM_006466; RPC39; RPC6; Q9H1D9; RPC6_HUMAN; More at Entrez

SIN3A SIN3 homolog A, transcription regulator (yeast) [Source:HGNC Symbol;Acc:19353] Functions:

Synonyms: ENSG00000169375; ENSP00000353622; ENSP00000378402; ENSP00000378403; 25942; SIN3A; NP_001138829; NP_001138830; NP_056292; NM_001145357; NM_001145358; NM_015477; DKFZP434K2235; Q96ST3; SIN3A_HUMAN; More at Entrez

MYB v-myb myeloblastosis viral oncogene homolog (avian) [Source:HGNC Symbol;Acc:7545] Functions:

Synonyms: ENSG00000118513; ENSP00000237302; ENSP00000326328; ENSP00000339992; ENSP00000341050; ENSP00000356786; ENSP00000356788; ENSP00000390460; ENSP00000403387; ENSP00000410825; ENSP00000413011; ENSP00000432042; ENSP00000432168; ENSP00000432811; ENSP00000432851; ENSP00000432877; ENSP00000432948; ENSP00000433227; ENSP00000433458; ENSP00000433745; ENSP00000433844; ENSP00000434420; ENSP00000434639; ENSP00000434675; ENSP00000434723; ENSP00000434795; ENSP00000434816; ENSP00000434917; ENSP00000435055; ENSP00000435293; ENSP00000435497; ENSP00000435578; ENSP00000435595; ENSP00000435938; ENSP00000436385; ENSP00000436602; ENSP00000436605; ENSP00000436925; ENSP00000437081; ENSP00000437264; 4602; MYB; NP_001123644; NP_001123645; NP_001155128; NP_001155129; NP_001155130; NP_001155131; NP_001155132; NP_005366; NM_001130172; NM_001130173; NM_001161656; NM_001161657; NM_001161658; NM_001161659; NM_001161660; NM_005375; c-myb; c-myb_CDS; Cmyb; MYB_HUMAN; P10242; More at Entrez

GPN1 GPN-loop GTPase 1 [Source:HGNC Symbol;Acc:17030] Functions:

Synonyms: ENSG00000198522; ENSP00000264718; ENSP00000384255; ENSP00000395981; ENSP00000398115; ENSP00000412170; ENSP00000424678; ENSP00000427269; 11321; GPN1; NP_001138519; NP_001138520; NP_001138521; NP_009197; NM_001145047; NM_001145048; NM_001145049; NM_007266; NR_026735; ATPBD1A; MBDIN; NTPBP; RPAP4; XAB1; GPN1_HUMAN; Q9HCN4; More at Entrez

POLR2F polymerase (RNA) II (DNA directed) polypeptide F [Source:HGNC Symbol;Acc:9193] Functions: 3 5 6 9 10 11 12 13 14 15 16 17 18 19 20 23 24 25 26 27 28 29 30 31 32 33 35

36 37 38

Synonyms: ENSG00000100142; ENSP00000332130; ENSP00000384112; ENSP00000385725; ENSP00000389307; ENSP00000403852; ENSP00000406826; 5435; POLR2F; NP_068809; NM_021974; HRBP14.4; POLRF; RPABC2; RPB14.4; RPB6; P61218; RPAB2_HUMAN; More at Entrez

UBTF upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:12511] Functions: 2 3 4 5 6 7 8

Synonyms: ENSG00000108312; ENSP00000302640; ENSP00000345297; ENSP00000377231; ENSP00000390669; ENSP00000431295; ENSP00000431539; ENSP00000432925; ENSP00000433046; ENSP00000433625; ENSP00000435708; ENSP00000437180; 7343; UBTF; NP_001070151; NP_001070152; NP_055048; NM_001076683; NM_001076684; NM_014233; NR_045058; NOR-90; UBF; UBF-1; UBF1; P17480; UBF1_HUMAN; More at Entrez

TTF1 transcription termination factor, RNA polymerase I [Source:HGNC Symbol;Acc:12397] Functions:

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2 3 4

Synonyms: ENSG00000125482; ENSP00000245588; ENSP00000333920; 7270; TTF1; NP_001192225; NP_031370; NM_001205296; NM_007344; TTF-I; Q15361; TTF1_HUMAN; More at Entrez

PTRF polymerase I and transcript release factor [Source:HGNC Symbol;Acc:9688] Functions: 2 3 4 6 7

Synonyms: ENSG00000177469; ENSP00000349541; ENSP00000350313; 284119; PTRF; NP_036364; NM_012232; CAVIN; cavin-1; CAVIN1; CGL4; PTRF_HUMAN; Q6NZI2; More at Entrez

POLR2H polymerase (RNA) II (DNA directed) polypeptide H [Source:HGNC Symbol;Acc:9195] Functions: 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

36 37 38

Synonyms: ENSG00000163882; ENSP00000296223; ENSP00000392913; ENSP00000393773; ENSP00000398622; ENSP00000399882; ENSP00000403728; ENSP00000409065; ENSP00000411883; ENSP00000415536; 5437; POLR2H; NP_006223; NM_006232; hsRPB8; RPABC3; RPB17; RPB8; P52434; RPAB3_HUMAN; More at Entrez

RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:30346] Functions: 2 6 7

Synonyms: ENSG00000085721; ENSP00000198767; ENSP00000318484; ENSP00000402027; ENSP00000437963; 54700; RRN3; NP_060897; NM_018427; A-270G1.2; DKFZp566E104; TIFIA; Q9NYV6; RRN3_HUMAN; More at Entrez

TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa [Source:HGNC Symbol;Acc:11534] Functions: 2 3 4 5 6 7 8

Synonyms: ENSG00000103168; ENSP00000345305; ENSP00000367802; ENSP00000437900; ENSP00000439849; ENSP00000442230; 9013; TAF1C; NP_001230085; NP_001230086; NP_001230087; NP_001230088; NP_001230089; NP_005670; NP_647610; NM_001243156; NM_001243157; NM_001243158; NM_001243159; NM_001243160; NM_005679; NM_139353; MGC:39976; TAFI110; TAFI95; Q15572; TAF1C_HUMAN; More at Entrez

POLR1E polymerase (RNA) I polypeptide E, 53kDa [Source:HGNC Symbol;Acc:17631] Functions:

Synonyms: ENSG00000137054; ENSP00000367023; ENSP00000367029; ENSP00000397455; ENSP00000399887; 64425; POLR1E; NP_071935; NM_022490; FLJ13390; FLJ13970; PAF53; RP11-405L18.3; Q9GZS1; RPA49_HUMAN; More at Entrez

TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa [Source:HGNC Symbol;Acc:11533] Functions: 2 3 4 5 6 7 8

Synonyms: ENSG00000115750; ENSP00000263663; ENSP00000379542; ENSP00000384598; ENSP00000385959; ENSP00000402955; ENSP00000414184; 9014; TAF1B; NP_005671; NM_005680; MGC:9349; RAF1B; RAFI63; TAFI63; Q53T94; TAF1B_HUMAN; More at Entrez

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Functions

Function FDR Coverage 1 query genes n/a 4 / 4 2 transcription from RNA polymerase I promoter 1.24E-24 12 / 31 3 transcription termination, DNA-dependent 2.28E-24 14 / 80 4 termination of RNA polymerase I transcription 2.14E-21 10 / 21 5 transcription elongation, DNA-dependent 3.43E-21 13 / 93 6 transcription initiation, DNA-dependent 3.47E-21 13 / 95 7 transcription initiation from RNA polymerase I promoter 3.47E-21 10 / 23 8 transcription elongation from RNA polymerase I promoter 3.08E-16 8 / 19 9 DNA-directed RNA polymerase complex 3.99E-16 8 / 20 10 nuclear DNA-directed RNA polymerase complex 3.99E-16 8 / 20 11 RNA polymerase complex 5.8E-16 8 / 21 12 termination of RNA polymerase III transcription 8.63E-14 7 / 18 13 transcription elongation from RNA polymerase III promoter 8.63E-14 7 / 18 14 transcription from RNA polymerase III promoter 2.44E-10 7 / 50 15 DNA-directed RNA polymerase II, core complex 1.23E-6 4 / 12 16 nucleotide-excision repair 2.04E-5 5 / 66 17 DNA-directed RNA polymerase II, holoenzyme 2.59E-5 5 / 70 18 mRNA capping 5.21E-5 4 / 30 19 RNA capping 5.21E-5 4 / 30 20 transcription-coupled nucleotide-excision repair 2.42E-4 4 / 44 21 DNA-directed RNA polymerase activity 3.36E-4 3 / 12 22 RNA polymerase activity 3.36E-4 3 / 12 23 positive regulation of viral transcription 4.47E-4 4 / 53 24 regulation of viral transcription 9.79E-4 4 / 65 25 transcription elongation from RNA polymerase II promoter 9.98E-4 4 / 66 26 positive regulation of viral reproduction 1.38E-3 4 / 73 27 transcription initiation from RNA polymerase II promoter 1.38E-3 4 / 73 28 positive regulation of reproductive process 1.57E-3 4 / 76 29 regulation of viral reproduction 2.72E-3 4 / 88 30 regulation of reproductive process 5.93E-3 4 / 108 31 DNA repair 1.15E-2 5 / 272 32 viral transcription 1.86E-2 4 / 148 33 viral genome expression 1.86E-2 4 / 148 34 nucleotidyltransferase activity 2.6E-2 3 / 56 35 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5.39E-2 4 / 199 36 nuclear mRNA splicing, via spliceosome 5.39E-2 4 / 199 37 RNA splicing, via transesterification reactions 5.88E-2 4 / 205 38 viral infectious cycle 7.91E-2 4 / 223

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Interactions

Gene 1 Gene 2 Weight Network group Networks POLR1E POLR1C 0.05299441143870354 Co-expression Gobble-Singer-2011 Nakayama-Hasegawa-2007 Noble-Diehl-2008 POLR2H POLR1C 0.052315068896859884 Co-expression Hummel-Siebert-2006 Jones-Libermann-2005 Radtke-Downing-2009 Raue-Trappe-2012 Rieger-Chu-2004 POLR2F POLR2L 0.05006556352600455 Co-expression Burington-Shaughnessy-2008 Hummel-Siebert-2006 Radtke-Downing-2009 Rieger-Chu-2004 TAF1C TCOF1 0.03268304094672203 Co-expression Burczynski-Dorner-2006 Hummel-Siebert-2006 POLR2H POLR2F 0.031273342901840806 Co-expression Hummel-Siebert-2006 Ramaswamy-Golub-2001 Rieger-Chu-2004 Wang-Maris-2006 POLR2H POLR2L 0.029264433309435844 Co-expression Burington-Shaughnessy-2008 Perou-Botstein-1999 POLR1B POLR1C 0.02799347834661603 Co-expression Noble-Diehl-2008 Radtke-Downing-2009 Toedter-Baribaud-2011 UBTF TP53 0.018856141716241837 Co-expression Arijs-Rutgeerts-2009 Hummel-Siebert-2006 POLR1E POLR1B 0.018781453371047974 Co-expression Noble-Diehl-2008 POLR2H UBTF 0.01759769581258297 Co-expression Burczynski-Dorner-2006 Raue-Trappe-2012 RRN3 POLR3F 0.01755282049998641 Co-expression Burczynski-Dorner-2006 Hummel-Siebert-2006 RRN3 POLR1B 0.016349932178854942 Co-expression Berchtold-Cotman-2008 TAF1B GPN1 0.01577702723443508 Co-expression Nakayama-Hasegawa-2007 POLR1E POLR2H 0.014650033786892891 Co-expression Hummel-Siebert-2006 TTF1 GPN1 0.013628131709992886 Co-expression Berchtold-Cotman-2008 GPN1 POLR1B 0.012004873715341091 Co-expression Peng-Katze-2009 GPN1 POLR1D 0.011355874128639698 Co-expression Peng-Katze-2009 UBTF TCOF1 0.011311623733490705 Co-expression Hummel-Siebert-2006 Peng-Katze-2009 POLR2L TCOF1 0.008954513818025589 Co-expression Rieger-Chu-2004 TTF1 POLR1C 0.008769222535192966 Co-expression Wang-Maris-2006 POLR2F POLR1D 0.008307566866278648 Co-expression Hummel-Siebert-2006 POLR2F POLR2C 0.007247660309076309 Co-expression Rieger-Chu-2004 POLR2F POLR1C 0.007141913287341595 Co-expression Hummel-Siebert-2006 POLR2H ZNRD1 0.006904680747538805 Co-expression Raue-Trappe-2012 TTF1 POLR1B 0.006768825463950634 Co-expression Radtke-Downing-2009 POLR1B TCOF1 0.004555733874440193 Co-expression Radtke-Downing-2009 TAF1C POLR2H 0.004304722882807255 Co-expression Peng-Katze-2009 TAF1C POLR1B 0.003631519852206111 Co-expression Radtke-Downing-2009 POLR2H GPN1 0.0035566245205700397 Co-expression Raue-Trappe-2012 TP53 TCOF1 0.015287617221474648 Co-localization Johnson-Shoemaker-2003 UBTF TP53 0.011607907712459564 Co-localization Johnson-Shoemaker-2003 TTF1 ZNRD1 0.00794569868594408 Co-localization Johnson-Shoemaker-2003 RFWD2 TP53 0.6730232015252113 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 MYB SIN3A 0.5637890240177512 Pathway PATHWAYCOMMONS-NCI_NATURE PATHWAYCOMMONS-REACTOME SIN3A TP53 0.3628394901752472 Pathway PATHWAYCOMMONS-REACTOME MYB TP53 0.3628394901752472 Pathway PATHWAYCOMMONS-REACTOME

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Gene 1 Gene 2 Weight Network group Networks RRN3 POLR1C 0.1458246186375618 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 RRN3 POLR1A 0.1458246186375618 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 RRN3 POLR1B 0.1458246186375618 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF TTF1 0.14107448607683182 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF POLR1C 0.13862960785627365 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF POLR1A 0.13862960785627365 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF POLR1B 0.13862960785627365 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C RRN3 0.1351505070924759 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B RRN3 0.1351505070924759 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 RRN3 UBTF 0.13222891837358475 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TTF1 POLR1C 0.13113992288708687 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TTF1 POLR1A 0.13113992288708687 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TTF1 POLR1B 0.13113992288708687 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1A POLR1C 0.12909648567438126 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1B POLR1C 0.12909648567438126 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1B POLR1A 0.12909648567438126 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C PTRF 0.12846234440803528 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B PTRF 0.12846234440803528 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF UBTF 0.1256781928241253 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C TTF1 0.12215796858072281 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B TTF1 0.12215796858072281 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TTF1 UBTF 0.11973979696631432 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C POLR1C 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C POLR1A 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C POLR1B 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B POLR1C 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B POLR1A 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B POLR1B 0.11938184127211571 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 UBTF POLR1C 0.11670558154582977 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 UBTF POLR1A 0.11670558154582977 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 UBTF POLR1B 0.11670558154582977 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B TAF1C 0.11133501678705215 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010

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Gene 1 Gene 2 Weight Network group Networks TAF1C UBTF 0.10917764902114868 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B UBTF 0.10917764902114868 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 RRN3 POLR1D 0.10856501385569572 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 PTRF POLR1D 0.10326792299747467 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1C POLR1D 0.0969071201980114 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1A POLR1D 0.0969071201980114 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR1B POLR1D 0.0969071201980114 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TTF1 POLR1D 0.09577823802828789 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C POLR1D 0.08680080808699131 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B POLR1D 0.08680080808699131 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 UBTF POLR1D 0.0838380977511406 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR3F POLR3H 0.057033585384488106 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 RRN3 POLR2H 0.030604212544858456 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H PTRF 0.02909355890005827 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H TTF1 0.027542217634618282 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR1C 0.02708494197577238 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR1A 0.02708494197577238 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR1B 0.02708494197577238 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1C POLR2H 0.025076947174966335 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 TAF1B POLR2H 0.025076947174966335 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H UBTF 0.024525683373212814 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR1D 0.020240852143615484 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR3H 0.017995670437812805 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2H POLR3F 0.017995670437812805 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2F POLR3H 0.009932531975209713 Pathway Wu-Stein-2010 POLR2F POLR3F 0.009932531975209713 Pathway Wu-Stein-2010 POLR2L POLR3H 0.009874592535197735 Pathway Wu-Stein-2010 POLR3F POLR2L 0.009874592535197735 Pathway Wu-Stein-2010 POLR2H POLR2C 0.007357744034379721 Pathway PATHWAYCOMMONS-REACTOME Wu-Stein-2010 POLR2F POLR2C 0.0038973321206867695 Pathway Wu-Stein-2010 POLR2L POLR2C 0.0038745980709791183 Pathway Wu-Stein-2010 TP53 POLR1D 0.0035816568415611982 Pathway Wu-Stein-2010 POLR2F POLR2L 0.0032394963782280684 Pathway Wu-Stein-2010 POLR2H POLR2F 0.0030434054788202047 Pathway Wu-Stein-2010 POLR2H POLR2L 0.0030256526079028845 Pathway Wu-Stein-2010

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Gene 1 Gene 2 Weight Network group Networks RRN3 POLR1B 1.4368633106350899 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-SMALL-SCALE-STUDIES POLR1C POLR1D 1.0504403114318848 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-INTACT IREF-SMALL-SCALE-STUDIES TAF1B TAF1C 0.8587040901184082 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-MINT IREF-SMALL-SCALE-STUDIES RRN3 POLR1A 0.6451053842902184 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-SMALL-SCALE-STUDIES PTRF TTF1 0.6403888463973999 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR1E POLR1C 0.5803605988621712 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-INTACT IREF-SMALL-SCALE-STUDIES POLR1B POLR1A 0.5637804418802261 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-INTACT IREF-SMALL-SCALE-STUDIES GPN1 TCOF1 0.563532218337059 Physical interactions BIOGRID-SMALL-SCALE-STUDIES Jeronimo-Coulombe-2007 POLR3H POLR1D 0.5239562839269638 Physical interactions BIOGRID-SMALL-SCALE-STUDIES Jeronimo-Coulombe-2007 POLR2F POLR2C 0.3485749512910843 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-SMALL-SCALE-STUDIES POLR2H POLR2L 0.3406679630279541 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-SMALL-SCALE-STUDIES TAF1B RRN3 0.30825871229171753 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-SMALL-SCALE-STUDIES TAF1C RRN3 0.23484709113836288 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR2H POLR2C 0.2263004146516323 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-SMALL-SCALE-STUDIES POLR1E RRN3 0.2197500616312027 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR1A POLR1C 0.21708431839942932 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR2L POLR2C 0.21192549914121628 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-SMALL-SCALE-STUDIES POLR1E POLR1A 0.1967935785651207 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR2L POLR1A 0.17394085973501205 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES TAF1C UBTF 0.15959029272198677 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR2H POLR3H 0.15867524594068527 Physical interactions BIOGRID-SMALL-SCALE-STUDIES Jeronimo-Coulombe-2007 POLR1E UBTF 0.14974116906523705 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR2H POLR1A 0.13747454807162285 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES POLR1E POLR1B 0.12723010778427124 Physical interactions IREF-SMALL-SCALE-STUDIES POLR1E TAF1C 0.1150503009557724 Physical interactions IREF-SMALL-SCALE-STUDIES TAF1B UBTF 0.1002437211573124 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES

第20页共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks RRN3 UBTF 0.09918853640556335 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES RFWD2 TP53 0.09116645995527506 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-MINT IREF-SMALL-SCALE-STUDIES UBTF TCOF1 0.08879648149013519 Physical interactions IREF-SMALL-SCALE-STUDIES SIN3A TP53 0.04129608068615198 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-INTACT IREF-SMALL-SCALE-STUDIES TAF1C TP53 0.02181276772171259 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES TAF1B TP53 0.014044425450265408 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES MYB SIN3A 0.008338980376720428 Physical interactions BIOGRID-SMALL-SCALE-STUDIES POLR1C POLR1D 3.441799560561776 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-IntAct-Fly2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-Tarassov-PCA-Yeast2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human Stuart-Kim-2003 POLR1B ZNRD1 1.3840446323156357 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human PTRF TTF1 1.0 Predicted I2D-MGI-Mouse2Human TAF1C UBTF 1.0 Predicted I2D-INNATEDB-Mouse2Human POLR2H POLR1A 0.8298430629074574 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR2H POLR3F 0.7048367559909821 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR2L POLR2C 0.6164088658988476 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR1E UBTF 0.5505102276802063 Predicted I2D-MGI-Mouse2Human POLR2F POLR2L 0.5102242939174175 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2F POLR1A 0.5003009140491486 Predicted I2D-BioGRID-Yeast2Human I2D-Tarassov-PCA-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human

第21页共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks POLR1B POLR1A 0.4934942349791527 Predicted I2D-BioGRID-Yeast2Human I2D-Tarassov-PCA-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2H POLR2C 0.4642408508807421 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2L POLR1C 0.4628187455236912 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2H ZNRD1 0.43228595703840256 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human Stuart-Kim-2003 POLR1A POLR1C 0.4087204709649086 Predicted I2D-BioGRID-Yeast2Human I2D-Tarassov-PCA-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR3H POLR1D 0.40834516659379005 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human Stuart-Kim-2003 ZNRD1 POLR1D 0.3979923203587532 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR3F POLR2L 0.3971976116299629 Predicted I2D-BioGRID-Yeast2Human I2D-Krogan-Greenblatt-2006-NonCore- Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2L ZNRD1 0.388639934360981 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR3F POLR3H 0.3766598030924797 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1B POLR2L 0.3584729991853237 Predicted I2D-BIND-Yeast2Human I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human SIN3A TP53 0.34491419792175293 Predicted I2D-BIND-Mouse2Human ZNRD1 POLR1C 0.3373086340725422 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human TAF1B TAF1C 0.3333333432674408 Predicted I2D-MGI-Mouse2Human POLR2H POLR3H 0.3175918906927109 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human

第22页共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks POLR2F POLR3H 0.31411265581846237 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2L POLR3H 0.30187076702713966 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2F ZNRD1 0.2856021448969841 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR1A ZNRD1 0.26698385179042816 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR3H POLR1C 0.2602542135864496 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR3F POLR1C 0.2529993373900652 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2F POLR1C 0.24347246810793877 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human Stuart-Kim-2003 POLR2F POLR2C 0.21192333847284317 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2C POLR1D 0.21184154599905014 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human POLR2H POLR1C 0.18268642015755177 Predicted I2D-BioGRID-Yeast2Human I2D-Li-Vidal-2004-interolog- Worm2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR1E POLR3F 0.17384841293096542 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR3F POLR1D 0.17302072793245316 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1E POLR1A 0.15776997804641724 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human RRN3 POLR1A 0.1465923935174942 Predicted I2D-BioGRID-Yeast2Human POLR1E POLR2F 0.13140543177723885 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2F POLR1D 0.13123420625925064 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1E ZNRD1 0.12455945461988449 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human

第23页共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks POLR1E POLR1C 0.11973503418266773 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2F POLR3F 0.11683361604809761 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1E POLR1B 0.10440737009048462 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR2L POLR1A 0.09695062413811684 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR2H POLR2L 0.09242084994912148 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR3F POLR1B 0.09224188514053822 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR3F POLR1A 0.0883014127612114 Predicted I2D-vonMering-Bork-2002- High-Yeast2Human RRN3 POLR1B 0.08741117268800735 Predicted I2D-BioGRID-Yeast2Human POLR1E POLR2L 0.08331841975450516 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2H POLR2F 0.08210313692688942 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR2H POLR1B 0.08036884106695652 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR1E POLR2H 0.07500526681542397 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2F POLR1B 0.06976061873137951 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1E POLR1D 0.06903833523392677 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR1B POLR1C 0.06380256917327642 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- High-Yeast2Human POLR1A POLR1D 0.062433574348688126 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2H POLR1D 0.060888539999723434 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR3F ZNRD1 0.04915152117609978 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2L POLR1D 0.03847617283463478 Predicted I2D-BioGRID-Yeast2Human POLR1B POLR1D 0.03530633356422186 Predicted I2D-BioGRID-Yeast2Human I2D-vonMering-Bork-2002- Low-Yeast2Human POLR1A POLR3H 0.033949024975299835 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human POLR1E POLR3H 0.03391522914171219 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human POLR1A POLR2C 0.025406721979379654 Predicted I2D-vonMering-Bork-2002-Medium- Yeast2Human POLR1B POLR2C 0.024021483957767487 Predicted I2D-vonMering-Bork-2002-Medium- Yeast2Human SIN3A POLR1C 0.01688564382493496 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human

第24页共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks POLR1B POLR3H 0.016727389767766 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human GPN1 POLR1B 0.006285037379711866 Predicted I2D-vonMering-Bork-2002- Low-Yeast2Human POLR2C POLR1C 0.8062065839767456 Shared protein domains INTERPRO PFAM POLR1C POLR1D 0.3599122613668442 Shared protein domains INTERPRO PFAM POLR2C POLR1D 0.3599122613668442 Shared protein domains INTERPRO PFAM TTF1 MYB 0.028836460784077644 Shared protein domains INTERPRO

Search results generated by the GeneMANIA algorithm (genemania.org)

第25页共25页 2012/12/5 13:27