GeneMANIA http://www.genemania.org/print Created on: 5 December 2012 00:06:51 Last database update: 19 July 2012 20:00:00 Application version: 3.1.1 Report of GeneMANIA search Network image POLR3H TAF1B POLR1B TAF1C POLR2L POLR2F RFWD2 0.33 Functions legend Networks legend transcription from RNA polymerase I promoter Co-expression query genes Co-localization Genetic interactions Pathway Physical interactions Predicted Shared protein domains 第1页 共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print Search parameters Organism: H. sapiens (human) Genes: TCOF1; TP53; POLR1C; POLR1D Networks: Attributes: Network weighting: Automatically selected weighting method (Biological process based) Number of gene results: 20 第2页 共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print Networks Co-expression 37.73 % Wang-Maris-2006 2.68 % Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Wang et al. (2006). Cancer Res . Source: Pearson correlation with 231,830 interactions from GEO Tags: transcription factors; cancer Ramaswamy-Golub-2001 2.44 % Multiclass cancer diagnosis using tumor gene expression signatures. Ramaswamy et al. (2001). Proc Natl Acad Sci U S A. Source: Pearson correlation with 226,615 interactions from supplementary material Tags: cancer Radtke-Downing-2009 2.33 % Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Radtke et al. (2009). Proc Natl Acad Sci U S A . Source: Pearson correlation with 377,767 interactions from GEO Tags: transcription factors; nervous system; cancer Gobble-Singer-2011 2.15 % Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Gobble et al. (2011). Cancer Res . Source: Pearson correlation with 449,507 interactions from GEO Tags: apoptosis; cell line; cultured cells; cancer; transcription factors Kang-Willman-2010 2.04 % Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Kang et al. (2010). Blood . Source: Pearson correlation with 549,783 interactions from GEO Tags: transcription factors; lymphoma; cancer Hummel-Siebert-2006 2.00 % A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. Hummel et al. (2006). N Engl J Med . Source: Pearson correlation with 466,765 interactions from GEO Tags: cancer Jones-Libermann-2005 1.99 % Gene signatures of progression and metastasis in renal cell cancer. Jones et al. (2005). Clin Cancer Res . Source: Pearson correlation with 365,428 interactions from GEO Tags: transcription factors; disease; cancer Bild-Nevins-2006 B 1.96 % Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al. (2006). Nature . Note: One of 3 datasets produced from this publication. Source: Pearson correlation with 254,105 interactions from GEO Tags: cultured cells; signal transduction; cancer; epithelial cells; cell line; disease; breast; transcription factors; breast cancer Noble-Diehl-2008 1.92 % Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Noble et al. (2008). Gut . Source: Pearson correlation with 603,016 interactions from GEO Wu-Garvey-2007 1.89 % The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Wu et al. (2007). 第3页 共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print Endocrine . Source: Pearson correlation with 223,988 interactions from GEO Tags: transcription factors; muscle; cultured cells Nakayama-Hasegawa-2007 1.89 % Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Nakayama et al. (2007). Mod Pathol . Source: Pearson correlation with 361,398 interactions from GEO Tags: transcription factors; cancer Burington-Shaughnessy-2008 1.88 % Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Burington et al. (2008). Clin Cancer Res . Source: Pearson correlation with 266,464 interactions from GEO Tags: transcription factors; time series; cancer; chemotherapy Burczynski-Dorner-2006 1.77 % Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Burczynski et al. (2006). J Mol Diagn . Source: Pearson correlation with 419,356 interactions from GEO Raue-Trappe-2012 1.72 % Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. Raue et al. (2012). J Appl Physiol . Source: Pearson correlation with 483,849 interactions from GEO Rieger-Chu-2004 1.72 % Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al. (2004). Proc Natl Acad Sci U S A . Source: Pearson correlation with 220,846 interactions from GEO Tags: cultured cells; cell line Arijs-Rutgeerts-2009 1.58 % Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs et al. (2009). PLoS One . Source: Pearson correlation with 570,210 interactions from GEO Tags: immune system Peng-Katze-2009 1.54 % Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al. (2009). BMC Genomics . Source: Pearson correlation with 349,954 interactions from GEO Tags: liver Berchtold-Cotman-2008 1.53 % Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold et al. (2008). Proc Natl Acad Sci U S A . Source: Pearson correlation with 507,933 interactions from GEO Tags: aging; brain Toedter-Baribaud-2011 1.49 % Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis. Toedter et al. (2011). Am J Gastroenterol . Source: Pearson correlation with 572,082 interactions from GEO Tags: signal transduction; immune system Perou-Botstein-1999 1.18 % Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al. (1999). Proc Natl Acad Sci U S A . 第4页 共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print Source: Pearson correlation with 50,804 interactions from supplementary material Tags: cultured cells; cancer; epithelial cells; signal transduction; breast; stromal cells; transcription factors; breast cancer Physical interactions 32.73 % Behzadnia-Lührmann-2007 8.91 % Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia et al. (2007). EMBO J . Source: Direct interaction with 101 interactions from iRefIndex Kneissl-Grummt-2003 5.94 % Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl et al. (2003). J Mol Biol . Source: Direct interaction with 83 interactions from iRefIndex Tags: cell proliferation; transcription factors; cultured cells; cell line McFarland-Nussbaum-2008 4.19 % Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland et al. (2008). Mol Cell Proteomics . Source: Direct interaction with 152 interactions from iRefIndex Tags: brain; nervous system Hutchins-Peters-2010 3.22 % Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al. (2010). Science . Source: Direct interaction with 141 interactions from iRefIndex Tags: cell proliferation; nervous system; localization Jeronimo-Coulombe-2007 2.10 % Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo et al. (2007). Mol Cell . Source: Direct interaction with 660 interactions from iRefIndex Tags: cultured cells; cell line Ramachandran-LaBaer-2004 1.26 % Self-assembling protein microarrays. Ramachandran et al. (2004). Science . Source: Direct interaction with 119 interactions from iRefIndex Goudreault-Gingras-2009 1.13 % A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Goudreault et al. (2009). Mol Cell Proteomics . Source: Direct interaction with 242 interactions from iRefIndex Tags: nervous system Sato-Conaway-2004 1.05 % A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato et al. (2004). Mol Cell . Source: Direct interaction with 235 interactions from iRefIndex Tags: transcription factors Barr-Knapp-2009 0.75 % Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr et al. (2009). Cell . Source: Direct interaction with 177 interactions from iRefIndex IREF-MPPI 0.52 % Source: Direct interaction with 385 interactions from iRefIndex Jones-MacBeath-2006 0.47 % A quantitative protein interaction network for the ErbB receptors using protein microarrays. Jones et al. (2006). Nature . 第5页 共25页 2012/12/5 13:27 GeneMANIA http://www.genemania.org/print Source: Direct interaction with 139 interactions from iRefIndex Tags: cultured cells; cell line Sowa-Harper-2009 A 0.42 % Defining the human deubiquitinating enzyme interaction landscape. Sowa et al. (2009).