Measurements Drugs* Medication Therapy for Persons albuterol sulfate with Asthma- Absence of beclomethasone dipropionate Controller Therapy and budesonide Medication Therapy for Persons budesonide/formoterol fumarate with Asthma-Suboptimal ciclesonide Control dornase alfa flunisolide fluticasone furoate fluticasone furoate/vilanterol trifenatate fluticasone propionate fluticasone propionate/salmeterol xinafoate ivacaftor levalbuterol HCl levalbuterol tartrate lumacaftor/ivacaftor mometasone furoate mometasone furoate/formoterol fumarate montelukast sodium salmeterol xinafoate tezacaftor/ivacaftor theophylline anhydrous tobramycin zafirlukast zileuton Medication Adherence for amlodipine besylate/atorvastatin calcium Cholesterol Medications atorvastatin calcium ezetimibe/simvastatin fluvastatin sodium lovastatin pitavastatin calcium pitavastatin magnesium pravastatin sodium rosuvastatin calcium simvastatin Medication Adherence for albiglutide Diabetes Medications alogliptin benzoate alogliptin benzoate/metformin HCl alogliptin benzoate/pioglitazone HCl buspirone HCl canagliflozin canagliflozin/metformin HCl chlorpropamide

*Representatives of drugs included in measurement April 4, 2019, Page 1 Measurements Drugs* Medication Adherence for dapagliflozin propanediol Diabetes Medications dapagliflozin propanediol/metformin HCl dapagliflozin propanediol/saxagliptin HCl dulaglutide empagliflozin empagliflozin/linagliptin empagliflozin/metformin HCl ertugliflozin pidolate ertugliflozin pidolate/metformin HCl ertugliflozin pidolate/sitagliptin phosphate exenatide exenatide microspheres glimepiride glipizide glipizide/metformin HCl glyburide glyburide,micronized glyburide/metformin HCl linagliptin linagliptin/metformin HCl liraglutide lixisenatide metformin HCl nateglinide pioglitazone HCl pioglitazone HCl/glimepiride pioglitazone HCl/metformin HCl repaglinide repaglinide/metformin HCl rosiglitazone maleate saxagliptin HCl saxagliptin HCl/metformin HCl semaglutide sitagliptin phosphate sitagliptin phosphate/metformin HCl tolazamide tolbutamide triamterene/hydrochlorothiazide High-Risk Medications amitriptyline HCl amitriptyline HCl/chlordiazepoxide amobarbital sodium amoxapine aspirin/dipyridamole atropine sulfate atropine sulfate in 0.9 % sodium chloride benztropine mesylate brompheniramine maleate/phenylephrine HCl/dextromethorphan brompheniramine maleate/pseudoephedrine HCl/dextromethorphan butabarbital sodium butalbital/acetaminophen *Representatives of drugs included in measurement April 4, 2019, Page 2 Measurements Drugs* butalbital/acetaminophen/caffeine High-Risk Medications butalbital/acetaminophen/caffeine/codeine phosphate butalbital/aspirin/caffeine carbinoxamine maleate carisoprodol carisoprodol/aspirin carisoprodol/aspirin/codeine phosphate chlordiazepoxide/clidinium bromide chlorpheniramine maleate/codeine phosphate chlorpheniramine maleate/phenylephrine HCl chlorpheniramine maleate/phenylephrine HCl/dextromethorphan chlorpheniramine maleate/pseudoephedrine HCl/codeine chlorpropamide chlorzoxazone clemastine fumarate clomipramine HCl codeine phosphate/butalbital/aspirin/caffeine cyclobenzaprine HCl cyclobenzaprine HCl/irritants counter-irritants combo no.2 cyclobenzaprine HCl/TENS unit electrodes cyclobenzaprine HCl/TENS unit/TENS unit electrodes cyproheptadine HCl desipramine HCl desogestrel-ethinyl estradiol desogestrel-ethinyl estradiol/ethinyl estradiol dicyclomine HCl difenoxin HCl/atropine sulfate digoxin dimenhydrinate diphenhydramine HCl diphenoxylate HCl/atropine sulfate dipyridamole disopyramide phosphate doxepin HCl doxylamine succinate/pyridoxine HCl (B6) drospirenone/estradiol drospirenone/ethinyl estradiol/levomefolate calcium ergoloid mesylates estradiol estradiol acetate estradiol/levonorgestrel estradiol/norethindrone acetate estradiol/norgestimate estradiol/progesterone estrogens, conjugated estrogens, conjugated/bazedoxifene acetate estrogens, conjugated/medroxyprogesterone acetate estrogens,esterified estrogens,esterified/methyltestosterone eszopiclone *Representatives of drugs included in measurement April 4, 2019, Page 3 Measurements Drugs* ethinyl estradiol/drospirenone ethynodiol diacetate-ethinyl estradiol High-Risk Medications etonogestrel/ethinyl estradiol glyburide glyburide,micronized glyburide/metformin HCl guaifenesin/dextromethorphan HBr/pseudoephedrine HCl guanfacine HCl hydrocodone bitart/chlorpheniramine maleate/pseudoephedrine hydrocodone polistirex/chlorpheniramine polistirex hydroxyzine HCl hydroxyzine pamoate hyoscyamine sulfate imipramine HCl imipramine pamoate indomethacin indomethacin sodium indomethacin, submicronized isoxsuprine HCl ketorolac tromethamine levonorgestrel/ethinyl estradiol and ethinyl estradiol levonorgestrel/ethinyl estradiol/ferrous bisglycinate levonorgestrel-ethinyl estradiol meclizine HCl megestrol acetate meperidine HCl meperidine HCl in 0.9 % sodium chloride meperidine HCl in 0.9 % sodium chloride/PF meperidine HCl/PF meprobamate metaxalone methenamine/methylene blue/benzoic acid/salicylat/hyoscyamin methenamine/sod phosph,monobasic/methylene blue/hyoscyamine methocarbamol methyldopa methyldopa/hydrochlorothiazide methyldopate HCl mycophenolate sodium nifedipine nitrofurantoin nitrofurantoin macrocrystal nitrofurantoin monohydrate/macrocrystals norethindrone acetate-ethinyl estradiol norethindrone acetate-ethinyl estradiol/ferrous fumarate norethindrone-ethinyl estradiol norethindrone-ethinyl estradiol/ferrous fumarate norgestimate-ethinyl estradiol norgestrel-ethinyl estradiol nortriptyline HCl opium/belladonna alkaloids *Representatives of drugs included in measurement April 4, 2019, Page 4 Measurements Drugs* orphenadrine citrate paroxetine HCl paroxetine mesylate High-Risk Medications pentazocine HCl/naloxone HCl pentazocine lactate pentobarbital sodium perphenazine/amitriptyline HCl phenobarbital phenobarbital sodium phenobarbital sodium in 0.9 % sodium chloride phenobarbital/hyoscyamine sulf/atropine sulf/scopolamine Hb phenylephrine HCl/promethazine HCl promethazine HCl promethazine HCl in 0.9 % sodium chloride promethazine HCl/codeine promethazine HCl/dextromethorphan HBr promethazine/phenylephrine HCl/codeine propantheline bromide protriptyline HCl pseudoephedrine HCl/chlorpheniramine maleate/bellad alk scopolamine secobarbital sodium thyroid,pork trihexyphenidyl HCl trimipramine maleate triprolidine HCl/phenylephrine HCl/codeine phosphate zaleplon zolpidem tartrate Medication Adherence for aliskiren hemifumarate Hypertension aliskiren hemifumarate/hydrochlorothiazide amlodipine besylate/benazepril HCl amlodipine besylate/olmesartan medoxomil amlodipine besylate/valsartan amlodipine besylate/valsartan/hydrochlorothiazide azilsartan medoxomil azilsartan medoxomil/chlorthalidone benazepril HCl benazepril HCl/hydrochlorothiazide candesartan cilexetil candesartan cilexetil/hydrochlorothiazide captopril captopril/hydrochlorothiazide enalapril maleate enalapril maleate/hydrochlorothiazide eprosartan mesylate fosinopril sodium fosinopril sodium/hydrochlorothiazide irbesartan irbesartan/hydrochlorothiazide lisinopril *Representatives of drugs included in measurement April 4, 2019, Page 5 Measurements Drugs* lisinopril/hydrochlorothiazide losartan potassium losartan potassium/hydrochlorothiazide moexipril HCl Medication Adherence for nebivolol HCl/valsartan Hypertension olmesartan medoxomil olmesartan medoxomil/amlodipine besylate/hydrochlorothiazide olmesartan medoxomil/hydrochlorothiazide perindopril arginine/amlodipine besylate perindopril erbumine quinapril HCl quinapril HCl/hydrochlorothiazide ramipril telmisartan telmisartan/amlodipine besylate telmisartan/hydrochlorothiazide trandolapril trandolapril/verapamil HCl valsartan valsartan/hydrochlorothiazide Statin Use in Patients with acarbose Diabetes albiglutide alogliptin benzoate alogliptin benzoate/metformin HCl alogliptin benzoate/pioglitazone HCl amlodipine besylate/atorvastatin calcium atorvastatin calcium buspirone HCl canagliflozin canagliflozin/metformin HCl chlorpropamide dapagliflozin propanediol dapagliflozin propanediol/metformin HCl dapagliflozin propanediol/saxagliptin HCl dulaglutide empagliflozin empagliflozin/linagliptin empagliflozin/metformin HCl ertugliflozin pidolate ertugliflozin pidolate/metformin HCl ertugliflozin pidolate/sitagliptin phosphate exenatide exenatide microspheres ezetimibe/simvastatin fluvastatin sodium glimepiride glipizide glipizide/metformin HCl glyburide glyburide,micronized *Representatives of drugs included in measurement April 4, 2019, Page 6 Measurements Drugs* glyburide/metformin HCl insulin aspart insulin aspart (niacinamide) insulin aspart protamine human/insulin aspart insulin degludec Statin Use in Patients with insulin degludec/liraglutide Diabetes insulin detemir insulin glargine,human recombinant analog insulin glargine,human recombinant analog/lixisenatide insulin glulisine insulin lispro insulin lispro protamine and insulin lispro insulin NPH human isophane insulin NPH human isophane/insulin regular, human insulin regular, human linagliptin linagliptin/metformin HCl liraglutide lixisenatide lovastatin metformin HCl miglitol nateglinide pioglitazone HCl pioglitazone HCl/glimepiride pioglitazone HCl/metformin HCl pitavastatin calcium pitavastatin magnesium pramipexole di-HCl pramlintide acetate pravastatin sodium repaglinide repaglinide/metformin HCl rosiglitazone maleate rosuvastatin calcium saxagliptin HCl saxagliptin HCl/metformin HCl semaglutide simvastatin sitagliptin phosphate sitagliptin phosphate/metformin HCl tolazamide tolbutamide triamterene/hydrochlorothiazide

*Representatives of drugs included in measurement April 4, 2019, Page 7