Descriptive Analysis of Pilocytic Astrocytomas using SEER 13 registry (1992-2002) and SEER 9 registry (1973-2002) data

Bridget J. McCarthy, Ph. D. Central Brain Tumor Registry of the United States

Brain Stem Pilocytic Astrocytoma Statistics

Selection: Histology = 9421 (Pilocytic astrocytoma) Primary site = C71.7 (Brain Stem: includes cerebral peduncle, basis pedunculi, choroid plexus of fourth ventricle, fourth ventricle NOS, infratentorial brain NOS, medulla oblongata, midbrain, olive, pons, pyramid)

Table 2. Annual percent change and incidence rates/100,000 person-years from the SEER 13 registry (1992-2002) data set by gender and race, age-adjusted to the 2000 US standard population. 1992-2002 (13 registries) N Rate/Trend (95% CI) Overall Incidence 124 0.029 (.024-.035)

1992-2002 Annual -0.1 (-5.9-6.0) Percent Change (APC) [No trend in incidence]

Gender: Male 60 0.028 (.021-.037) Female 64 0.030 (.023-.039)

Age at Diagnosis: 0-14 years 77 0.083 (.066-.104) < 20 years 86 0.070 (.056-.087) 20+ years 38 0.013 (.009-.017)

Race: Caucasian 100 0.031 (.026-.038) African American 9 0.016 (.007-.036) Asian/Pacific Islander 10 0.022 (.010-.045)

0.12

0.10

0.08

0.06

0.04

0.02

Incidence/100,000 person-years 0.00 001-0405-09 10-14 15-19 20-24 years years years years years

Figure 6. Incidence rates for brain stem pilocytic astrocytoma by age at diagnosis; SEER 1992- 2002, 13 registries.

4% Malignant tumor 5% 2% Malignant glioma 4% Ependymal tumors 4% Astrocytoma, NOS 6% 34% Anaplastic astrocytoma Fibrillary astrocytoma 11% Pilocytic astrocytoma Glioblastoma 2% Medulloblastoma 4% PNET 12% 13% Lymphoma 24 other histologies

Figure 7. The percentage of tumors in the Brain Stem (site code C71.7) by specific histology; SEER 1992-2002, 13 registries. 100 90 80 70 60 All Pilocytic 50 All Brain Stem Pilocytic 40 % Survival 30 20 10 0 0 1224364860 Months since diagnosis

Figure 8. Comparison of the relative survival rates for all pilocytic astrocytoma and brain stem specific pilocytic astrocytoma; SEER 1973-2002, 9 registries. - No significant differences between the two groups.

Brain Stem Pilocytic Astrocytomas

100 90 80 70 60 Male 50 40 Female

% Survival 30 20 10 0 0 1224364860 Months since diagnosis

Figure 9. Relative survival rates for brain stem pilocytic astrocytoma by gender; SEER 1973- 2002, 9 registries. - No significant differences between the two groups.

100 90 Brain Stem Pilocytic 80 <20 yrs 70 Brain Stem Pilocytic 60 20+ yrs 50 Pilocytic at other 40

% Survival sites <20 yrs 30 Pilocytic at other 20 sites 20+ yrs 10 0 0 1224364860 Months since diagnosis

Figure 10. Relative survival rates for brain stem pilocytic astrocytoma and for pilocytic astrocytoma for all other Brain and CNS sites by age groups (<20 years and 20+ years); SEER 1973-2002, 9 registries. - Significantly lower survival was found in those 20+ years at diagnosis compared to those <20 years at diagnosis. References: Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 9 Regs Public-Use, Nov 2004 Sub (1973-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.

Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 13 Regs Public-Use, Nov 2004 Sub for Expanded Races (1992-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.

Analyses conducted and provided by the Central Brain Tumor Registry of the United States using SEER 13 registry (1992-2002) and SEER 9 registry (1973-2002) data. The CBTRUS is not responsible for interpretations of these data made elsewhere and restricts its support to its analyses and statements placed on this website.