1. Tumours of Neuroepithelial Tissue • • • • • • • • • • • • • • • •
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WHO Classification of Tumors of the Central Nervous System 1. Tumours of Neuroepithelial 1.4 Ependymal tumours Tissue • Ependymoma 1.1 Astrocytic tumours • Variants: Cellular • Diffuse astrocytoma • Papillary • Variants: Fibrillary astrocytoma • Clear cell • Protoplasmic astrocytoma • Tanycytic • Gemistocytic astrocytoma • Anaplastic ependymoma • Anaplastic astrocytoma • Myxopapillary ependymoma • Glioblastoma • Subependymoma • Variants: Giant cell glioblastoma 1.5 Choroid plexus tumours • Gliosarcoma • Choroid plexus papilloma • Pilocytic astrocytoma • Choroid plexus carcinoma • Pleomorphic xanthoastrocytoma 1.6 Glial tumours of uncertain origin • Subependymal giant cell astrocytoma • Astroblastoma 1.2 Oligodendroglial tumours • Gliomatosis cerebri • Oligodendroglioma • Chordoid glioma of the 3rd ventricle • Anaplastic oligodendroglioma 1.7 Neuronal and mixed neuronalglial tumours 1.3 Mixed gliomas • Gangliocytoma • Oligoastrocytoma • Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos) • Anaplastic oligoastrocytoma • Desmoplastic infantile astrocytoma/ganglioglioma • Oligodendroglioma • Dysembryoplastic neuroepithelial tumour • Anaplastic oligodendroglioma • Ganglioglioma Page 1 of 4 WHO Classification of Tumors of the Central Nervous System • Anaplastic ganglioglioma • tumour (PNET) • Central neurocytoma • Variants: Neuroblastoma • Cerebellar liponeurocytoma • Ganglioneuroblastoma • Paraganglioma of the filum terminale • Atypical teratoid/rhabdoid tumour 1.8 Neuroblastic tumours • Olfactory neuroblastoma (Aesthesioneuroblastoma) 2. Tumours of Peripheral Nerves 2.1 Schwannoma • Olfactory neuroepithelioma (Neurilemmoma, Neurinoma) • Neuroblastomas of the adrenal gland and sympathetic nervous • Variants: Cellular system • 1.9 Pineal parenchymal tumours • Plexiform Melanotic • Pineocytoma • 2.2 Neurofibroma • Pineoblastoma Variant: Plexiform • Pineal parenchymal tumour of intermediate differentiation • 1.10 Embryonal tumours 2.3 Perineurioma Variants: Intraneual perineurioma • Medulloepithelioma • Soft tissue perineurioma • Ependymoblastoma • 2.4 Malignant peripheral nerve sheath tumour (MPNST) • Medulloblastoma Variants: Epithelioid • Variants: Desmoblastic medulloblastoma • MPNST with divergent mesenchymal and/or epithelial differentia- • Large cell medulloblastoma • tion • Medullomyoblastoma Melanotic • Melanotic medulloblastoma • Melanotic psamomatous • Supratentorial primitive neuroectodermal • Page 2 of 4 WHO Classification of Tumors of the Central Nervous System 3. Tumours of Meninges • Liposarcoma (intracranial) 3.1 Tumours of meningothelial cells • Solitary fibrous tumour • Meningioma • Fibrosarcoma • Variants: Meningothelial • Malignant fibrous histiocytoma • Fibrous (fibroblastic) • Leiomyoma • Transitional (mixed) • Leiomyosarcoma • Psammomatous • Rhabdomyosarcoma • Angiomatous • Chondroma • Microcystic • Chondrosarcoma • Secretory • Osteoma • Lymphoplasmacyte-rich • Osteosarcoma • Metaplastic • Osteochondroma • Clear cell • Haemangioma • Chordoid • Epitheloid haemangioendothelioma • Atypical • Haemangiopericytoma • Papillary • Angiosarcoma • Rhabdoid • Kaposi sarcoma • Anaplastic 3.3 Primary melanocytic lesions 3.2 Mesenchymal, nonmeningothelial tumours • Diffuse melanocytosis • Lipoma • Melanocytoma • Angiolipoma • Malignant melanoma • Hibernoma • Meningeal melanomatosis Page 3 of 4 WHO Classification of Tumors of the Central Nervous System 3.4 Tumours of uncertain histogenesis • Granular cell tumour • Haemangioblastoma 7. Metastatic Tumours 4. Lymphomas and Haemopoetic • Neoplasms • Malignant lymphoma • Plasmacytoma • Granulocytic sarcoma 5. Germ Cell Tumours • Germinoma • Embryonal carcinoma • Yolk sac tumour • Choriocarcinoma • Teratoma • Variants: Mature • Immature • Teratoma with malignant • transformation • Mixed germ cell tumours 6. Tumours of the Sellar Region • Craniopharyngeom • Variants: Adamantinomatous • Papillary Page 4 of 4.