DOCSLIB.ORG

MP/H Rules Presentation

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
MP/H Rules Presentation Malignant Meninges, Brain, Spinal Cord, Cranial Nerves, Pituitary Gland, Craniopharyngeal Duct and Pineal Gland 1 Equivalent Terms, Definitions, Charts and Illustrations • Benign and borderline intracranial and CNS tumors have a separate set of rules. 2 Equivalent Terms, Definitions, Charts and Illustrations • PNET (Primitive neuroectodermal tumor) – Central PNET – Supratentorial PNET • pPNET –not brain primary 3 Chart 1 Neuroepithelial Brain CNS • WHO Classification of Tumors of the brain and central nervous system • Not complete listing 4 Chart Instructions: Use this chart to code histology. The tree is arranged Neuroepithelial in descending order. Each branch is a histology group, starting at the top (9503) with the least specific terms and descending into more specific terms. Embryonal Ependymal Pineal Choroid plexus Neuronal and mixed Neuroblastic Glial Oligodendroglial tumors tumors tumors tumors neuronal-glial tumors tumors tumors tumors Ependymoma, Pineoblastoma Choroid plexus Olfactory neuroblastoma Oligodendroglioma NOS (9391) (9362) carcinoma Ganglioglioma, anaplastic (9522) NOS (9450) (9390) (9505 Olfactory neurocytoma Oligodendroglioma Ganglioglioma, malignant (9521) anaplastic (9451) Anasplastic ependymoma (9505) Olfactory neuroepithlioma Oligodendroblastoma (9392) (9523) (9460) Papillary ependymoma (9393) Glioma, NOS (9380) Atypical Ependymoblastoma Medulloepithelioma Medulloblastoma Supratentorial primitive tetratoid/rhabdoid (9392) (9501) (9470) neuroectodermal tumor tumor (9508) (PNET) (9473) Teratoid Demoplastic (9471) Neuroblastoma (9500) medulloepthelioma Large cell (9474) Ganglioneuroblastoma (9502) Medullomyoblastoma (9490) (9472) Mixed glioma Glial tumors of (9382) Astrocytic un certain tumors origin Astroblastoma (9430) Pleomorphic Gliomatosis cerebri (9381) Astrocytoma, Pilocytic xanthoastrocytoma Polar spongioblastoma NOS (9400) astrocytoma (9423) (9421) (9424) Anaplastic astrocytoma Glioblastoma, NOS (9401) and Glioblastoma Fibrillary astrocytoma multiforme (9440) (9420) Gemistocytic Giant cell glioblastoma astrocytoma (9411) (9441) Key:The ovals( )represent Protoplasmic Gliosarcoma (9442) group terms. astromytoma (9410) 5 Chart 2 Non-Neuroepithelial Brain CNS • WHO Classification of Tumors of the brain and central nervous system • Not complete listing 6 Non- Neuroepithelial Peripheral Germ Cell Meningioma, Nerve Tumors malignant Malignant peripheral Choriocarcinoma (9100) Meningeal sarcomatosis (9539) nerve sheath tumor (9540) Embryonal carcionoma Papillary meningioma, rhadboid Malignant peripheral nerve sheath (9070) meningioma (9538) tumor with rhabdomyoblastic Germinoma (9064) differentiation (MPNST) (9561) Immature teratoma (9080) Neurilemoma, malignant Mixed germ cell tumor (9085) (9560) Teratoma with malignant Perineurioma, malignant (9571) transformation (9084) Yolk sac tumor (9071) 7 Multiple Primary Rules 8 Unknown if Single or Multiple Tumors 9 Rule Site Behavior Notes/ Primary Examples UNKNOWN IF SINGLE OR Tumor(s) not MULTIPLE TUMORS described as metastasis M1 Brain Invasive (/3) and Multiple either a benign (/0) or uncertain/borderline (1) tumor 10 Rule Notes/Examples Primary UNKNOWN IF SINGLE Tumor(s) not described as metastasis OR MULTIPLE TUMOR M2 Use this rule only after all Single information sources have been exhausted. 11 Single Tumor 12 Rule Site Notes/Examples Primary SINGLE TUMOR Tumor not described as metastasis M3 Single The tumor may overlap onto or Single extend into adjacent/contiguous site or subsite 13 Multiple Tumors 14 Rule Site Behavior Notes/ Primary Examples MULTIPLE TUMORS Tumors not Multiple tumors may be a single described as primary or multiple primaries metastases M4 Brain Invasive (/3) and Multiple either a benign (/0) or uncertain/border- line (1) tumor 15 Rule Site Primary M5 Tumors with topography codes different Multiple at the second (Cxxx) and/or third (Cxxx) character 16 Rule Histology Primary M6 Glioblastoma or glioblastoma Single multiforme (9440) following a glial tumor (See Chart 1) 17 Rule Histology Notes/Examples Primary M7 Tumors Recurrence, progression or Single with any reappearance of histology histologies on the same codes on branch in Chart 1 or Chart 2 the same is always the same disease branch in process. Chart 1 or Example: Patient has Chart 2 astrocytoma. Ten years later the patient is diagnosed with glioblastoma multiforme. This is a progression or recurrence of the earlier astrocytoma. 18 Rule Histology Primary M8 Tumors with histology codes on different Multiple branches in Chart 1 or Chart 2 19 Rule Histology Primary M9 Tumors with histology codes different Multiple at the first (xxxx), second (xxxx), or third (xxxx) number 20 Rule Notes/Examples Primary M10 Does 1: Neither timing nor laterality is used Single not to determine multiple primaries for meet malignant intracranial and CNS tumors. any of Example: The patient is treated for an the anaplastic astrocytoma (9401) in the above right parietal lobe. Three months later criteria the patient is diagnosed with a separate anaplastic astrocytoma in the left parietal lobe. This is one primary because laterality is not used to determine multiple primary status. 2: Multi-centric brain tumors which involve different lobes of the brain that do not meet any of the above criteria are the same disease process. 21 Histology Rules 22 Single Tumor 23 Rule Pathology/ Notes/Examples Code Cytology SINGLE TUMOR H1 No 1: Priority for using The pathology/ documents to code the histology cytology histology documented specimen or •Documentation in the by the the medical record that refers to physician pathology/ pathologic or cytologic cytology findings report is not •Physician’s reference to available type of cancer (histology) in the medical record •CT or MRI scans 24 Rule Pathology/ Notes/Examples Code Cytology SINGLE TUMOR H1 No 2: Code the specific The Continued pathology/ histology when histology cytology documented. documented specimen or 3: Code the histology by the the to 8000 physician pathology/ (cancer/malignant cytology neoplasm, NOS) as report is not stated by the physician available when nothing more specific is documented 25 Rule Pathology/Cytology Notes/ Code Specimen Examples H2 None from primary Code the The histology site behavior /3 from metastatic site 26 Rule Histology Code H3 At least two of the following Code 9382/3 (mixed cells and/or differentiation are glioma) present: •Astrocytoma •Oligodendroglioma •Ependymal 27 Rule Histology Code SINGLE TUMOR H4 One type The histology 28 Rule Histology Code H5 Diagnosis includes a non-specific The specific term and a specific term or type on the type same branch in Chart 1 or Chart 2 29 Rule Code H6 None of the above The histology with the conditions are met numerically higher ICD-O-3 code 30 Multiple Tumors Abstracted as a Single Primary 31 Rule Pathology/ Notes/Examples Code Cytology MULTIPLE TUMORS ABSTRACTED AS A SINGLE PRIMARY H7 No 1: Priority for using The pathology/ documents to code the histology cytology histology documented specimen or •Documentation in the by the the medical record that refers to physician pathology/ pathologic or cytologic cytology findings report is not •Physician’s reference to type available of cancer (histology) in the medical record •CT or MRI scans 32 Rule Pathology/ Notes/Examples Code Cytology MULTIPLE TUMORS ABSTRACTED AS A SINGLE PRIMARY H7 No 2: Code the specific The histology Continued pathology/ histology when documented cytology documented. by the specimen or 3: Code the histology to physician the 8000 (cancer/malignant pathology/ neoplasm, NOS) as stated cytology by the physician when report is not nothing more specific is available documented 33 Rule Pathology/Cytology Notes/ Code Specimen Examples H8 None from primary Code the The histology site behavior /3 from metastatic site 34 Rule Histology Code MULTIPLE TUMORS ABSTRACTED AS A SINGLE PRIMARY H9 One type The histology 35 Rule Histology Code H10 Diagnosis includes a non-specific The specific term and a specific term or type on type the same branch in Chart 1 or Chart 2 36 Rule Code H11 None of the above The histology with the conditions are met numerically higher ICD-O-3 code 37 MP/H Task Force 38.
Load more

Recommended publications
  • Risk Factors for Gliomas and Meningiomas in Males in Los Angeles County1
    [CANCER RESEARCH 49, 6137-6143. November 1, 1989] Risk Factors for Gliomas and Meningiomas in Males in Los Angeles County1 Susan Preston-Martin,2 Wendy Mack, and Brian E. Henderson Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles, California 90033 ABSTRACT views with proxy respondents, we were unable to include a large proportion of otherwise eligible cases because they were deceased or Detailed job histories and information about other suspected risk were too ill or impaired to participate in an interview. The Los Angeles factors were obtained during interviews with 272 men aged 25-69 with a County Cancer Surveillance Program identified the cases (26). All primary brain tumor first diagnosed during 1980-1984 and with 272 diagnoses had been microscopically confirmed. individually matched neighbor controls. Separate analyses were con A total of 478 patients were identified. The hospital and attending ducted for the 202 glioma pairs and the 70 meningioma pairs. Meningi- physician granted us permission to contact 396 (83%) patients. We oma, but not glioma, was related to having a serious head injury 20 or were unable to locate 22 patients, 38 chose not to participate, and 60 more years before diagnosis (odds ratio (OR) = 2.3; 95% confidence were aphasie or too ill to complete the interview. We interviewed 277 interval (CI) = 1.1-5.4), and a clear dose-response effect was observed patients (74% of the 374 patients contacted about the study or 58% of relating meningioma risk to number of serious head injuries (/' for trend the initial 478 patients).
    [Show full text]
  • Malignant Peripheral Nerve Sheath Tumor (MPNST): an Overview with Emphasis on Pathology, Imaging and Management Strategies
    Thomas Jefferson University Jefferson Digital Commons Department of Neurosurgery Faculty Papers Department of Neurosurgery 6-2012 Malignant Peripheral Nerve Sheath Tumor (MPNST): An overview with emphasis on pathology, imaging and management strategies Timothy C. Beer 3rd year medical student, Jefferson Medical College Follow this and additional works at: https://jdc.jefferson.edu/neurosurgeryfp Part of the Medical Neurobiology Commons Let us know how access to this document benefits ouy Recommended Citation Beer, Timothy C., "Malignant Peripheral Nerve Sheath Tumor (MPNST): An overview with emphasis on pathology, imaging and management strategies" (2012). Department of Neurosurgery Faculty Papers. Paper 18. https://jdc.jefferson.edu/neurosurgeryfp/18 This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Department of Neurosurgery Faculty Papers by an authorized administrator of the Jefferson Digital Commons. For more information, please contact: [email protected]. An overview with emphasis
    [Show full text]
  • Original Article Outcome of Supratentorial Intraaxial Extra Ventricular Primary Pediatric Brain Tumors
    Original Article Outcome of supratentorial intraaxial extra ventricular primary pediatric brain tumors: A prospective study Mohana Rao Patibandla, Suchanda Bhattacharjee1, Megha S. Uppin2, Aniruddh Kumar Purohit1 Department of Neurosurgery, Krishna Institute of Medical Sciences Secunderabad, Departments of 1Neurosurgery and 2Pathology, Nizam’s Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India Address for correspondence: Dr. Mohana Rao Patibandla, Department of Neurosurgery, University of Colorado Denver, 13123, E 16th Ave, Aurora, CO 80045, USA. Email: [email protected] ABSTRACT Introduction: Tumors of the central nervous system (CNS) are the second most frequent malignancy of childhood and the most common solid tumor in this age group. CNS tumors represent approximately 17% of all malignancies in the pediatric age range, including adolescents. Glial neoplasms in children account for up to 60% of supratentorial intraaxial tumors. Their histological distribution and prognostic features differ from that of adults. Aims and Objectives: To study clinical and pathological characteristics, and to analyze the outcome using the Engel’s classification for seizures, Karnofsky’s score during the available follow‑up period of minimum 1 year following the surgical and adjuvant therapy of supratentorial intraaxial extraventricular primary pediatric (SIEPP) brain tumors in children equal or less than 18 years. Materials and Methods: The study design is a prospective study done in NIMS from October 2008 to January 2012. All the patients less than 18 years of age operated for SIEPP brain tumors proven histopathologically were included in the study. All the patients with recurrent or residual primary tumors or secondaries were excluded from the study. Post operative CT or magnetic resonance imaging (MRI) is done following surgery.
    [Show full text]
  • Charts Chart 1: Benign and Borderline Intracranial and CNS Tumors Chart
    Charts Chart 1: Benign and Borderline Intracranial and CNS Tumors Chart Glial Tumor Neuronal and Neuronal‐ Ependymomas glial Neoplasms Subependymoma Subependymal Giant (9383/1) Cell Astrocytoma(9384/1) Myyppxopapillar y Desmoplastic Infantile Ependymoma Astrocytoma (9412/1) (9394/1) Chart 1: Benign and Borderline Intracranial and CNS Tumors Chart Glial Tumor Neuronal and Neuronal‐ Ependymomas glial Neoplasms Subependymoma Subependymal Giant (9383/1) Cell Astrocytoma(9384/1) Myyppxopapillar y Desmoplastic Infantile Ependymoma Astrocytoma (9412/1) (9394/1) Use this chart to code histology. The tree is arranged Chart Instructions: Neuroepithelial in descending order. Each branch is a histology group, starting at the top (9503) with the least specific terms and descending into more specific terms. Ependymal Embryonal Pineal Choro id plexus Neuronal and mixed Neuroblastic Glial Oligodendroglial tumors tumors tumors tumors neuronal-glial tumors tumors tumors tumors Pineoblastoma Ependymoma, Choroid plexus Olfactory neuroblastoma Oligodendroglioma NOS (9391) (9362) carcinoma Ganglioglioma, anaplastic (9522) NOS (9450) Oligodendroglioma (9390) (9505 Olfactory neurocytoma Ganglioglioma, malignant (()9521) anaplastic (()9451) Anasplastic ependymoma (9505) Olfactory neuroepithlioma Oligodendroblastoma (9392) (9523) (9460) Papillary ependymoma (9393) Glioma, NOS (9380) Supratentorial primitive Atypical EdEpendymo bltblastoma MdllMedulloep ithliithelioma Medulloblastoma neuroectodermal tumor tetratoid/rhabdoid (9392) (9501) (9470) (PNET) (9473) tumor
    [Show full text]
  • Central Nervous System Tumors General ~1% of Tumors in Adults, but ~25% of Malignancies in Children (Only 2Nd to Leukemia)
    Last updated: 3/4/2021 Prepared by Kurt Schaberg Central Nervous System Tumors General ~1% of tumors in adults, but ~25% of malignancies in children (only 2nd to leukemia). Significant increase in incidence in primary brain tumors in elderly. Metastases to the brain far outnumber primary CNS tumors→ multiple cerebral tumors. One can develop a very good DDX by just location, age, and imaging. Differential Diagnosis by clinical information: Location Pediatric/Young Adult Older Adult Cerebral/ Ganglioglioma, DNET, PXA, Glioblastoma Multiforme (GBM) Supratentorial Ependymoma, AT/RT Infiltrating Astrocytoma (grades II-III), CNS Embryonal Neoplasms Oligodendroglioma, Metastases, Lymphoma, Infection Cerebellar/ PA, Medulloblastoma, Ependymoma, Metastases, Hemangioblastoma, Infratentorial/ Choroid plexus papilloma, AT/RT Choroid plexus papilloma, Subependymoma Fourth ventricle Brainstem PA, DMG Astrocytoma, Glioblastoma, DMG, Metastases Spinal cord Ependymoma, PA, DMG, MPE, Drop Ependymoma, Astrocytoma, DMG, MPE (filum), (intramedullary) metastases Paraganglioma (filum), Spinal cord Meningioma, Schwannoma, Schwannoma, Meningioma, (extramedullary) Metastases, Melanocytoma/melanoma Melanocytoma/melanoma, MPNST Spinal cord Bone tumor, Meningioma, Abscess, Herniated disk, Lymphoma, Abscess, (extradural) Vascular malformation, Metastases, Extra-axial/Dural/ Leukemia/lymphoma, Ewing Sarcoma, Meningioma, SFT, Metastases, Lymphoma, Leptomeningeal Rhabdomyosarcoma, Disseminated medulloblastoma, DLGNT, Sellar/infundibular Pituitary adenoma, Pituitary adenoma,
    [Show full text]
  • UCSD Moores Cancer Center Neuro-Oncology Program
    UCSD Moores Cancer Center Neuro-Oncology Program Recent Progress in Brain Tumors 6DQWRVK.HVDUL0'3K' 'LUHFWRU1HXUR2QFRORJ\ 3URIHVVRURI1HXURVFLHQFHV 0RRUHV&DQFHU&HQWHU 8QLYHUVLW\RI&DOLIRUQLD6DQ'LHJR “Brain Cancer for Life” Juvenile Pilocytic Astrocytoma Metastatic Brain Cancer Glioblastoma Multiforme Glioblastoma Multiforme Desmoplastic Infantile Ganglioglioma Desmoplastic Variant Astrocytoma Medulloblastoma Atypical Teratoid Rhabdoid Tumor Diffuse Intrinsic Pontine Glioma -Mutational analysis, microarray expression, epigenetic phenomenology -Age-specific biology of brain cancer -Is there an overlap? ? Neuroimmunology ? Stem cell hypothesis Courtesy of Dr. John Crawford Late Effects Long term effect of chemotherapy and radiation on neurocognition Risks of secondary malignancy secondary to chemotherapy and/or radiation Neurovascular long term effects: stroke, moya moya Courtesy of Dr. John Crawford Importance Increase in aging population with increased incidence of cancer Patients with cancer living longer and developing neurologic disorders due to nervous system relapse or toxicity from treatments Overview Introduction Clinical Presentation Primary Brain Tumors Metastatic Brain Tumors Leptomeningeal Metastases Primary CNS Lymphoma Paraneoplastic Syndromes Classification of Brain Tumors Tumors of Neuroepithelial Tissue Glial tumors (astrocytic, oligodendroglial, mixed) Neuronal and mixed neuronal-glial tumors Neuroblastic tumors Pineal parenchymal tumors Embryonal tumors Tumors of Peripheral Nerves Shwannoma Neurofibroma
    [Show full text]
  • What Are Brain and Spinal Cord Tumors in Children? ● Types of Brain and Spinal Cord Tumors in Children
    cancer.org | 1.800.227.2345 About Brain and Spinal Cord Tumors in Children Overview and Types If your child has just been diagnosed with brain or spinal cord tumors or you are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. ● What Are Brain and Spinal Cord Tumors in Children? ● Types of Brain and Spinal Cord Tumors in Children Research and Statistics See the latest estimates for new cases of brain and spinal cord tumors in children in the US and what research is currently being done. ● Key Statistics for Brain and Spinal Cord Tumors in Children ● What’s New in Research for Childhood Brain and Spinal Cord Tumors? What Are Brain and Spinal Cord Tumors in Children? Brain and spinal cord tumors are masses of abnormal cells in the brain or spinal cord 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 that have grown out of control. Are brain and spinal cord tumors cancer? In most other parts of the body, there's an important difference between benign (non- cancerous) tumors and malignant tumors (cancers1). Benign tumors do not invade nearby tissues or spread to distant areas, and are almost never life threatening in other parts of the body. Malignant tumors (cancers) are so dangerous mainly because they can spread throughout the body. Brain tumors rarely spread to other parts of the body, though many of them are considered malignant because they can spread through the brain and spinal cord tissue. But even so-called benign tumors can press on and destroy normal brain tissue as they grow, which can lead to serious or sometimes even life-threatening damage.
    [Show full text]
  • Risk-Adapted Therapy for Young Children with Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma Or Ependymoma (Sjyc07)
    SJCRH SJYC07 CTG# - NCT00602667 Initial version, dated: 7/25/2007, Resubmitted to CPSRMC 9/24/2007 and 10/6/2007 (IRB Approved: 11/09/2007) Activation Date: 11/27/2007 Amendment 1.0 dated January 23, 2008, submitted to CPSRMC: January 23, 2008, IRB Approval: March 10, 2008 Amendment 2.0 dated April 16, 2008, submitted to CPSRMC: April 16, 2008, (IRB Approval: May 13, 2008) Revision 2.1 dated April 29, 2009 (IRB Approved: April 30, 2009 ) Amendment 3.0 dated June 22, 2009, submitted to CPSRMC: June 22, 2009 (IRB Approved: July 14, 2009) Activated: August 11, 2009 Amendment 4.0 dated March 01, 2010 (IRB Approved: April 20, 2010) Activated: May 3, 2010 Amendment 5.0 dated July 19, 2010 (IRB Approved: Sept 17, 2010) Activated: September 24, 2010 Amendment 6.0 dated August 27, 2012 (IRB approved: September 24, 2012) Activated: October 18, 2012 Amendment 7.0 dated February 22, 2013 (IRB approved: March 13, 2013) Activated: April 4, 2013 Amendment 8.0 dated March 20, 2014. Resubmitted to IRB May 20, 2014 (IRB approved: May 22, 2014) Activated: May 30, 2014 Amendment 9.0 dated August 26, 2014. (IRB approved: October 14, 2014) Activated: November 4, 2014 Un-numbered revision dated March 22, 2018. (IRB approved: March 27, 2018) Un-numbered revision dated October 22, 2018 (IRB approved: 10-24-2018) RISK-ADAPTED THERAPY FOR YOUNG CHILDREN WITH EMBRYONAL BRAIN TUMORS, HIGH-GRADE GLIOMA, CHOROID PLEXUS CARCINOMA OR EPENDYMOMA (SJYC07) Principal Investigator Amar Gajjar, M.D. Division of Neuro-Oncology Department of Oncology Section Coordinators David Ellison, M.D., Ph.D.
    [Show full text]
  • Malignant CNS Solid Tumor Rules
    Malignant CNS and Peripheral Nerves Equivalent Terms and Definitions C470-C479, C700, C701, C709, C710-C719, C720-C725, C728, C729, C751-C753 (Excludes lymphoma and leukemia M9590 – M9992 and Kaposi sarcoma M9140) Introduction Note 1: This section includes the following primary sites: Peripheral nerves C470-C479; cerebral meninges C700; spinal meninges C701; meninges NOS C709; brain C710-C719; spinal cord C720; cauda equina C721; olfactory nerve C722; optic nerve C723; acoustic nerve C724; cranial nerve NOS C725; overlapping lesion of brain and central nervous system C728; nervous system NOS C729; pituitary gland C751; craniopharyngeal duct C752; pineal gland C753. Note 2: Non-malignant intracranial and CNS tumors have a separate set of rules. Note 3: 2007 MPH Rules and 2018 Solid Tumor Rules are used based on date of diagnosis. • Tumors diagnosed 01/01/2007 through 12/31/2017: Use 2007 MPH Rules • Tumors diagnosed 01/01/2018 and later: Use 2018 Solid Tumor Rules • The original tumor diagnosed before 1/1/2018 and a subsequent tumor diagnosed 1/1/2018 or later in the same primary site: Use the 2018 Solid Tumor Rules. Note 4: There must be a histologic, cytologic, radiographic, or clinical diagnosis of a malignant neoplasm /3. Note 5: Tumors from a number of primary sites metastasize to the brain. Do not use these rules for tumors described as metastases; report metastatic tumors using the rules for that primary site. Note 6: Pilocytic astrocytoma/juvenile pilocytic astrocytoma is reportable in North America as a malignant neoplasm 9421/3. • See the Non-malignant CNS Rules when the primary site is optic nerve and the diagnosis is either optic glioma or pilocytic astrocytoma.
    [Show full text]
  • Malignant Peripheral Nerve Sheath Tumors with T(X; 18). a Pathologic and Molecular Genetic Study Maureen J
    Malignant Peripheral Nerve Sheath Tumors with t(X; 18). A Pathologic and Molecular Genetic Study Maureen J. O’Sullivan, Michael Kyriakos, Xiaopei Zhu, Mark R. Wick,1 Paul E. Swanson, Louis P. Dehner, Paul A. Humphrey, John D. Pfeifer L.V. Ackerman Laboratory of Surgical Pathology, Washington University Medical Center, St. Louis, Missouri. KEY WORDS: Chromosomal translocation; malig- Spindle cell sarcomas often present the surgical pa- nant peripheral nerve sheath tumor; specificity; sy- thologist with a considerable diagnostic challenge. novial sarcoma; t(X;18). Malignant peripheral nerve sheath tumor, leiomy- Mod Pathol 2000;13(11):1253–1263 osarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The Spindle cell sarcomas include a wide variety of tu- application of ancillary diagnostic modalities, such mors, some of which, such as synovial sarcoma (SS) as immunohistochemistry and electron micros- and malignant peripheral nerve sheath tumor copy, may be helpful in the differentiation of these (MPNST), may have overlapping histologic fea- tumors, but in cases in which these adjunctive tech- tures. Because SS has classically been recognized as niques fail to demonstrate any more definitive evi- a neoplasm arising in the juxta-articular peripheral dence of differentiation, tumor categorization may soft tissue in adolescents or young adults (1–6), and remain difficult. Cytogenetic and molecular genetic MPNST has been associated with peripheral nerves, characterization of tumors have provided the basis especially in persons with neurofibromatosis (NF- for the application of molecular assays as the new- 1), clinical features have often been used as a est components of the diagnostic armamentarium. means to discriminate between the two tumors.
    [Show full text]
  • New Jersey State Cancer Registry List of Reportable Diseases and Conditions Effective Date March 10, 2011; Revised March 2019
    New Jersey State Cancer Registry List of reportable diseases and conditions Effective date March 10, 2011; Revised March 2019 General Rules for Reportability (a) If a diagnosis includes any of the following words, every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report the case to the Department in accordance with the provisions of N.J.A.C. 8:57A. Cancer; Carcinoma; Adenocarcinoma; Carcinoid tumor; Leukemia; Lymphoma; Malignant; and/or Sarcoma (b) Every New Jersey health care facility, physician, dentist, other health care provider or independent clinical laboratory shall report any case having a diagnosis listed at (g) below and which contains any of the following terms in the final diagnosis to the Department in accordance with the provisions of N.J.A.C. 8:57A. Apparent(ly); Appears; Compatible/Compatible with; Consistent with; Favors; Malignant appearing; Most likely; Presumed; Probable; Suspect(ed); Suspicious (for); and/or Typical (of) (c) Basal cell carcinomas and squamous cell carcinomas of the skin are NOT reportable, except when they are diagnosed in the labia, clitoris, vulva, prepuce, penis or scrotum. (d) Carcinoma in situ of the cervix and/or cervical squamous intraepithelial neoplasia III (CIN III) are NOT reportable. (e) Insofar as soft tissue tumors can arise in almost any body site, the primary site of the soft tissue tumor shall also be examined for any questionable neoplasm. NJSCR REPORTABILITY LIST – 2019 1 (f) If any uncertainty regarding the reporting of a particular case exists, the health care facility, physician, dentist, other health care provider or independent clinical laboratory shall contact the Department for guidance at (609) 633‐0500 or view information on the following website http://www.nj.gov/health/ces/njscr.shtml.
    [Show full text]
  • Adrenal and Paraganglia Tumors Adrenal Cortical Tumors IHC: (+) SF1, Inhibin, Melan-A, Calretinin, Synaptophysin, (-) Chromogranin, Cytokeratin, S100
    Last updated: 11/11/2020 Prepared by Kurt Schaberg Adrenal and Paraganglia Tumors Adrenal Cortical Tumors IHC: (+) SF1, Inhibin, Melan-A, Calretinin, Synaptophysin, (-) Chromogranin, Cytokeratin, S100. Often variable!! Adrenal Cortical Adenoma Benign. Very common. Often incidentally identified. Usually unilateral solitary masses with atrophic background adrenal gland. Tumor cells can be lipid-rich (clearer) or lipid-poor (pinker) arranged in nests and cords separated by abundant vasculature. Occasional lipofuscin pigment. Nuclei generally small and round (occasional extreme “endocrine atypia” is common). Low/no mitotic activity. Intact reticulin framework. On a spectrum with and may hard to differentiate from hyperplastic nodules, which is more often multinodular (background hyperplasia) and bilateral. Can be non-functional (85%) or functional (15%). Associated with MEN1, FAP, Carney Complex, among Aldosterone-producing→ “Conn syndrome”→ others… hypertension and hypokalemia If aldosterone-secreting adenoma is treated with Cortisol-producing→ (ACTH-independent) spironolactone→ “spironolactone bodies” (below) “Cushing Syndrome” → central obesity, moon face, hirsutism, poor healing, striae Sex-hormone-producing→ Rare (more common in carcinomas). Symptoms depend on hormone/sex (virilization or feminization) Adrenal Cortical Carcinoma Malignant. Most common in older adults. Can present with an incidental unilateral mass or with an endocrinopathy (see above). Solid, broad trabeculae, or large nested growth (more diffuse, and larger groups than in adenomas) Thick fibrous capsule with occasional fibrous bands. Frequent tumor necrosis. Frequent vascular or capsular invasion. Increased mitotic activity. Variants: Oncocytic, Myxoid, Sarcomatoid Mostly sporadic, but can be associated with Lynch Syndrome and Li-Fraumeni Syndrome Distinguishing between an Adrenal Cortical Adenoma vs Carcinoma Weiss Criteria: Weiss Criteria (≥3 = Malignant) Most widely used system, but doesn’t work as well High nuclear grade (based of Fuhrman criteria) in borderline cases or variants.
    [Show full text]