20th Congress of the International Society for Human and Animal Mycology Geographic distribution of cryptococcosis in the state of Mato Grosso do Sul, Central-West Brazil region Marilene Rodrigues Chang, Rosianne Assis de Sousa Tsujisaki, Maína de Oliveira Nunes, Gláucia Moreira Espíndola Lima, Amanda Borges Colman, Dario Corrêa Júnior, Anamaria Mello Miranda Paniago, Simone Schneider Weber, Rinaldo Poncio Mendes Federal University of Mato Grosso do Sul, Campo Grande-MS, Brazil
INTRODUCTION RESULTS
Cryptococcosis is a systemic mycosis of global Of 79 cities in the Mato Grosso do Sul state, 35 distribution caused by species of the complexes (44.3%) had at least one case of cryptococcosis. Of the Cryptococcus neoformans and Cryptococcus gattii1 that 220 cases studied, 150 (68.2%) were from Campo can be found in soil, bird droppings, tree hollows and Grande, capital of Mato Grosso do Sul (126; 84% C. decaying wood.2,3 The Central-West Brazil region neoformans VNI, 9; 6% C. neoformans VNII and 15; 10% presents favorable environmental conditions (tropical of C. deuterogattii). Eight cases of cryptococcosis were altitude climate and average temperature between 20°C identified in the Pantanal region (Aquidauana, Anastácio, and 25°C) for the development of these fungi. The Mato Corumbá, Ladário and Miranda), seven by C. neoformans Grosso do Sul state is home to 65% of the Pantanal, an VNI and one by C. deuterogattii. The found molecular incredible biodiversity scenario with rich fauna and flora,4 types are similar to other Brazillian regions (Figures 1 and where birds migrate that can influence the geographical 2). The Figure 3 shows the Cryptococcosis cases distribution of Cryptococcus spp. in the region. grouped into each three years. Thee patients had a mean age of 40 years and consisted mostly of men (75.7%). OBJECTIVES Most of the Cryptococcus isolates were obtained from patients with human immunodeficiency virus (HIV) and The objective of this study was to document included 169 (97.1%) and five (2.9%) isolates of C. cases of cryptococcosis in Mato Grosso do Sul, Brazil neoformans and C. gattii complexes, respectively. according to the cities and to determine the molecular types of Cryptococcus spp involved. Figure 2- Frequency of Figure 3- Cryptococcosis cases grouped into Cryptococcus molecular types. each three years
80 VNI VNII VGII METHODS 70 Were included Cryptococcus spp. isolated from 60 5.5% 10.5% different clinical specimens isolated of inpatients at 50 University Hospital of the Federal University of Mato 40 Grosso do Sul from 1997 to 2016. The molecular types 30 were identified by the URA5-RFLP method.5 20 10 84%
Figure 1 - Distribution of molecular types of Cryptococcus in the state of 0 Number ofcases cryptococcosis of Mato Grosso do Sul and other regions of Brazil
Year CONCLUSION
The present study documents the occurrence of cryptococcosis, which is mainly caused by C. neoformans VNI in Mato Grosso do Sul, Brazil, with probable autochthonous cases in the Brazilian Pantanal, the world’s largest tropical wetland and a biome where cryptococcosis has not yet been explored.
Legend: (1) Água Clara. (2) Alcinópolis. (3) Amambai. (4) Anastácio. (5) Anaurilândia. (6) REFERENCES Angélica. (7) Antônio João. (8) Aparecida do Taboado. (9) Aquidauana. (10) Aral Moreira. (11) Bandeirantes. (12) Bataguassu. (13) Batayporã. (14) Bela Vista. (15) Bodoquena. (16) 1. KWON-CHUNG, K. J. et al. The case for adopting the “species complex” Bonito. (17) Brasilândia. (18) Caarapó. (19) Camapuã. (20) Campo Grande. (21) Caracol. nomenclature for the etiologic agents of cryptococcosis. American Society for (22) Cassilândia. (23) Chapadão do Sul. (24) Corguinho. (25) Coronel Sapucaia. (26) Microbiology, v. 2, n. 1, p. 1-7, Jan./Feb. 2017. Corumbá. (27) Costa Rica. (28) Coxim. (29) Deodápolis. (30) Dois Irmãos do Buriti. (31) 2. ELLIS, D.; PFEIFFER, T. The ecology of Cryptococcus neoformans. European Douradina. (32) Dourados. (33) Eldorado. (34) Fátima do Sul. (35) Figueirão. (36) Glória de Journal of Epidemiology, v. 8, n.3, p. 321-325, May 1992. Dourados. (37) Guia Lopes da Laguna. (38) Iguatemi. (39) Inocência. (40) Itaporã. (41) 3. LAZÉRA, M. S.; SALMITO CAVALCANTI, M. A.; LONDERO, A. T.; TRILLES, L.; Itaquiraí. (42) Ivinhema. (43) Japorã. (44) Jaraguari. (45) Jardim. (46) Jateí. (47) Juti. (48) NISHIKAWA, M. M.; WANKE, B. Possible primary ecological niche of Ladário. (49) Laguna Carapã. (50) Maracaju. (51) Miranda. (52) Mundo Novo. (53) Naviraí. Cryptococcus neoformans. Medical Mycology, v. 38, n. 5, p. 379-383, Oct. 2000. (54) Nioaque. (55) Nova Alvorada do Sul. (56) Nova Andradina. (57) Novo Horizonte do 4. Governo do Estado Mato Grosso do Sul. Turismo MS. Perfil MS. Available in: Sul. (58) Paraíso das Águas. (59) Paranaíba. (60) Paranhos. (61) Pedro Gomes. (62)
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