Collegenews Issue25

Total Page:16

File Type:pdf, Size:1020Kb

Collegenews Issue25 HERTF collegeRDnews Issue 25, 2014 Oxford to Venice: Into the mix: Royal Institution: Bridge to Bridge bike ride, Celebrating 40 years of Reflections on the July 2014 co-education Christmas Lectures 2013 Issue25 Paul Wilkinson Paul FROM 12 WILL HUTTON I hope you like the new look Hertford was one of the first five Hertford’s academic community colleges to introduce co-education at is also looking to the future: we 16 Hertford College News. We’ve Oxford by admitting women in 1974 are currently embarking on an 6 10 updated our design but many (p. 10) – a fact echoed evocatively evaluation of the educational of the themes we cover will be when Alison Woollard delivered the and community experience that Royal Institution’s Christmas lectures we provide for graduates. Part Contents familiar. We carry on pushing at in 2013 (p. 12), only the fifth woman of this will involve a review of the boundaries that hold back to do so since their inauguration in the support we give to emerging fair opportunity. Equality and 1825. We currently have ten female academic talent as they navigate 3 From Will Hutton 12 Of worms and (wo)men: reflections Fellows at Hertford, a quarter of the a new world of digital publication access remain central Hertford fellowship, which despite being one and information sharing. Lucie on the Royal Institution Christmas values. But for all our pioneering of the more balanced gender ratios Burgess’s article (p. 16) about the 4 College news in Oxford, is still far from where we British Library touches on some of Lectures 2013 initiatives, I am constantly struck would like it to be. Student numbers the themes that our own graduates Alison Woollard that there is so much more we 6 Bridge to Bridge bike ride tell an intriguing story: of the current are facing, from preserving want to do. undergraduates, 232 are female and our academic heritage to the Farzana Aslam (1991), Jonathan Beckett 16 Libraries in the digital age 171 are male, a 58:42 percentage importance of curation in an age of (2007), Jamie Castell split. Amongst graduates, the ratio digital information dominance. Lucie Burgess (1993) is reversed – of our 206 graduates, 121 are male and 85 are female. Our most ambitious venture in 10 Into the mix: celebrating 40 years 18 Hertford rugby in Mongolia Does a career in academia pose a recent years is without doubt the of co-education at Oxford less attractive prospect to female decision to cycle 1,100km between John Collis (1989), Richard Foord (2011) students, or is there something else Oxford and Venice to raise funds Kate Stross (1974), Ellen Cheetham (2012) going on? for student support (p. 6). Again, this project emerged from one of 20 Dates for your diary When it comes to crossing Hertford’s longstanding convictions: boundaries, the Hertford rugby that it must continue to admit the team took this quite literally as best students, regardless of their they travelled across continents to financial background. We pioneered become only the second foreign team the outreach work that is now being to play in Mongolia (p. 18). As well as carried out across all Oxford and Hertford College News is published by being an unforgettable experience Cambridge colleges, and the bike the Members’ and Development Office for those who took part, it galvanised ride is the next step towards making for for members and friends of the college. an interest in Mongolian affairs at these access projects bigger and The opinions expressed are those of the writers and not necessarily the official Hertford as the team prepared for the bolder than ever. Hertford is using Call news trip, opening up discussions about its history to inform its future, and views of Hertford College. the global economy and a focus on a the funds raised by the bike ride Do you have a story you would like featured in the Editor: Claire Blake part of the world that does not often will allow us to build a system of Design: www.dougdawson.co.uk next issue of Hertford College News? Cover photo: Paul Wilkinson feature in our news. Perhaps it was student support that is essential Hertford’s tradition of supporting the for a new era of tuition fees, ever- Produced by: under-dog that led to the team being increasing competition for places, Email us at [email protected]. Members’ and Development Office beaten by the locals in their far- and uncertain job prospects after Hertford College Eastern matches! graduation. I’ll be cycling the full Oxford OX1 3BW distance, along with dozens of other T: +44 (0) 1865 279428 E: [email protected] Hertfordians – and I very much hope W: www.hertford.ox.ac.uk you will support us along the way! Hertford College is a registered charity in England and Wales, number 1137527 2 www.hertford.ox.ac.uk [email protected] 3 HertfordCollegeNews Issue25 Frost Included Top scientists Stephen Frost Two of Hertford’s scientists, Professor (1995) was the Dame Kay Davies and Professor Hagan first ever Head Bayley, were named in the Science of Diversity and Council’s Top 100 Scientists list. Inclusion for the Kay was recognised for her research Olympic Games into molecular analysis of human at London 2012. genetic disease, particularly the COLLEGE His new book genetic basis of neuromuscular and The Inclusion neurological disorders, and as co- NEWS Imperative founder of the Oxford Centre of Gene examines how real inclusion creates Function, of which she is also the Terry Hughes (1964-2013) better business and builds better co-Director. Terry Hughes, who passed away on 24 October We welcome our societies, building on his success in 2013 at the age of 49, was a staunch supporter new Director of achieving unprecedented workforce Hagan was praised for his ground of Hertford. His tireless enthusiasm and energy inclusion across the 200,000 staff breaking research into the structures was valued enormously by the college, as well Development supporting the Olympics. and properties of biological as his financial support towards the boat club In January, molecules, especially proteins, and and student bursaries. Hertford their relationship to biological welcomed Julia evolution and disease. Hertford hosted a celebration of Terry’s life Thaxton as the in April with 38 of Terry’s friends, family and new Director of colleagues, as well as Hertford fellows and Development. representatives of the boat club. Over tea, we She was Harvey Anthony heard light-hearted stories from Terry’s time previously at St at Hertford and reminiscences about the many John’s College, lives he had touched. Even the weather reflected the mood of the day, with Cambridge, bursts of sunshine tempered by April rain showers. where she was Head of Major In tribute to Terry, his old room will be named after him and a plaque installed Gifts for their successful £50 to remember him. The boat club will also name their annual AGM dinner, when million fundraising campaign. current and past members gather together for a meal in Hall, in Terry’s memory. “I’m absolutely delighted to be A memorial fund for Terry has been established to provide bursaries and joining Hertford at such an exciting financial assistance for students in need, as well as continuing his support of time. The college, students and the boat club. In addition, Terry’s wife Maria will be joining us for the bike ride alumni have all given me a very this summer, cycling the full 704 miles (see pages 6-9). To make a contribution warm welcome, and together with We Day to Terry’s memorial fund, or to sponsor Maria on the bike ride, please contact Anna, Claire and Helena, I look Marc Kielburger (2000) and his brother Craig are co-founders of the international development and youth the Development Office. forward to building ever-stronger empowerment organisation, Free The Children. On 7th March they celebrated We Day, an event to inspire young relationships with old members.” people to become agents of change. They were joined by Prince Harry, Al Gore, Malala Yousafzai and Hertford’s Law Fellow Dr Alison Young, who is also a trustee of the UK branch of the charity. New Hertford film Hertford talking We’ve been delighted with the response from alumni who have watched our new Recent speakers at our Hertford video on Hertford (tinyurl.com/hertvid). Current students, Fellows and alumni Conversations have included Ian (including Natasha Kaplinsky and a few other familiar faces) all discuss what McEwan (author) who shared makes Hertford stand out from the crowd, especially our work on open access. anecdotes from researching his novels, Charlie Mayfield (Chairman Our thanks go to Anthony Geffen (CEO and Executive Producer at Atlantic of John Lewis partnership) on the Productions) for his generosity and talent in producing the film for us. Anthony advantages of a partnership model, came to the college for Geography tutorials with Professor Andrew Goudie whilst and Ben Summerskill (former CEO studying at St Benet’s Hall. Law books of Stonewall) on equality in the the 2016 date for renewal of the twenty first century. BBC’s Royal Charter draws closer. It’s not all about sponsored Hertford’s cyclists… Hertford is extremely grateful We were also The lecture was supported by an to Mayer Brown International The Oxford University Darts team delighted to exhibition on John Donne in the LLP for generously sponsoring recently won the 2014 National welcome Tony Hall Bodleian Library’s Proscholium, textbooks for law students for University Championship, ably (Director-General arranged by Hertford student Alice the next five years.
Recommended publications
  • 100 Years of Genetics
    Heredity (2019) 123:1–3 https://doi.org/10.1038/s41437-019-0230-2 EDITORIAL 100 years of genetics Alison Woollard1 Received: 27 April 2019 / Accepted: 28 April 2019 © The Genetics Society 2019 The UK Genetics Society was founded on 25 June 1919 and “biometricians”; the Genetical Society was very much a this special issue of Heredity, a journal owned by the society of Mendelians. Remarkably, 16 of the original 87 Society, celebrates a century of genetics from the perspec- members were women—virtually unknown in scientific tives of nine past (and present) presidents. societies at the time. Saunders was a vice president from its The founding of the Genetical Society (as it was then beginning and its 4th president from 1936–1938. Perhaps known) is often attributed to William Bateson, although it the new, and somewhat radical, ideas of “genetics” pre- was actually the brain child of Edith Saunders. The enthu- sented a rare opportunity for women to engage in research siasm of Saunders to set up a genetics association is cited in because the field lacked recognition in universities, and was the anonymous 1916 report “Botany at the British Asso- therefore less attractive to men. 1234567890();,: 1234567890();,: ciation”, Nature, 98, 2456, p. 238. Furthermore, the actual Bateson and Saunders (along with Punnett) were also founding of the Society in 1919 “largely through the energy influential in the field of linkage analysis (“partial coupling” as of Miss E.R Saunders” is reported (anonymously) in they referred to it at the time), having made several observa- “Notes”, Nature, 103, 2596, p.
    [Show full text]
  • Issue 82 of the Genetics Society Newsletter
    JANUARY 2020 | ISSUE 82 GENETICS SOCIETY NEWS In this issue The Genetics Society News is edited by Margherita Colucci and items for future • Medal and Prize Lecture Announcements issues can be sent to the editor by email • “A Century of Genetics” conference to [email protected]. • Celebrating the centenary of Fisher 1918 The Newsletter is published twice a year, • Research and travel grant reports with copy dates of July and January. Speakers’ dinner at the “A Century of Genetics” conference, November 2019, Edinburgh. (Photo by Douglas Vernimmen) A WORD FROM THE EDITOR A word from the editor Welcome to Issue 82 elcome to the latest issue of reports in the Sectional Interest Wthe GenSoc Newsletter and Groups: Reports section. my first steps (pages?) as new editor. And why not (re)discovering another I am eager to start this journey with great milestone such as the publishing you through the latest Genetics of Fisher’s 1918 paper, “The correlation Society achievements and genetics between relatives on the supposition news! I would like to thank all of Mendelian inheritance”, recently GenSoc committee for giving me this reaching its centenary recurrence? opportunity. I am sure you will greatly enjoy the In this issue, I will bring you back to report in the Features section. the inspiring and lively atmosphere Enjoy! of the GenSoc meeting ‘A Century of Genetics’ in Edinburgh (November Best wishes, 2019) - a really big thanks to all of those Margherita Colucci who kindly contributed. Many Sectional Interest groups have been very active: you will find their In this issue, I will bring you back to the inspiring and lively atmosphere of the GenSoc meeting “A Century of Genetics” in Edinburgh (November 2019) - a really big thanks to all of those who kindly contributed.
    [Show full text]
  • Neuronal Function of Tbx20 Conserved from Nematodes to Vertebrates
    Available online at www.sciencedirect.com Developmental Biology 317 (2008) 671–685 www.elsevier.com/developmentalbiology Genomes & Developmental Control Neuronal function of Tbx20 conserved from nematodes to vertebrates Roger Pocock a,1,2, Marina Mione b,1,3, Sagair Hussain c, Sara Maxwell a, Marco Pontecorvi d, ⁎ ⁎ Sobia Aslam a, Dianne Gerrelli e, Jane C. Sowden c, , Alison Woollard a, a Genetics Unit, Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, UK b Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK c Developmental Biology Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK d Department of Biology, University College London, Gower Street, London WC1E 6BT, UK e Neural Development Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK Received for publication 27 September 2007; revised 4 February 2008; accepted 6 February 2008 Available online 21 February 2008 Abstract The Tbx20 orthologue, mab-9, is required for development of the Caenorhabditis elegans hindgut, whereas several vertebrate Tbx20 genes promote heart development. Here we show that Tbx20 orthologues also have a role in motor neuron development that is conserved between invertebrates and vertebrates. mab-9 mutants exhibit guidance defects in dorsally projecting axons from motor neurons located in the ventral nerve cord. Danio rerio (Zebrafish) tbx20 morphants show defects in the migration patterns of motor neuron soma of the facial and trigeminal motor neuron groups. Human TBX20 is expressed in motor neurons in the developing hindbrain of human embryos and we show that human TBX20 can substitute for zebrafish tbx20 in promoting cranial motor neuron migration.
    [Show full text]
  • Genetics Society News
    JULY 2016 | ISSUE 75 GENETICS SOCIETY NEWS In this issue The Genetics Society News is edited by Manuela Marescotti and items for future • Medal awarded issues can be sent to the editor, by email to • Meetings [email protected]. • Student and Travel Reports The Newsletter is published twice a year, with copy dates of July and January. Cover image: Coming of Age: The Legacy of Dolly at 20 Interview with Professor Sir Ian Wilmut. See page 19 A WORD FROM THE EDITOR A word from the editor Welcome to Issue 75 Welcome to a new issue of our could lead to a world populated newsletter. by “photocopies” of few perfect I would like to point out the people; till now, after studying interesting interview granted genetics for almost the past 20 by Professor Sir Ian Wilmut to years, I learned the real and Dr Kay Boulton and Dr Doug less catastrophic meaning of Vernimmen on the occasion of “cloning”, but, more importantly, the 20th anniversary of the birth the implications in different of Dolly the sheep. Who would fields. have thought that such a mild and Also you will find a big number gentle animal, as a sheep could of reports authored by scientists revolutionise the scientific world? that have been supported by our Her Finn Dorset and Blackface Society, to form themselves, or ‘parents’ could never have dreamt new generations of geneticists or of such great things. to progress in their research. It is funny to think for me, how Read on and enjoy. this achievement changed shape Best wishes, in my mind since 1998 when I was Manuela Marescotti just a teen-ager, believing that it Professor Sir Ian Wilmut discusses the 20th anniversary of the birth of Dolly the sheep.
    [Show full text]
  • Caenorhabditis Elegans
    Canterbury Christ Church University’s repository of research outputs http://create.canterbury.ac.uk Copyright © and Moral Rights for this thesis are retained by the author and/or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder/s. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given e.g. Stastna, J. (2016) Natural Variation in lifespan and stress responses in Caenorhabditis elegans. Ph.D. thesis, Canterbury Christ Church University. Contact: [email protected] Natural Variation in Lifespan and Stress Responses in Caenorhabditis elegans by Jana J Stastna Canterbury Christ Church University Thesis submitted for the Degree of Doctor of Philosophy 2016 I II Acknowledgements This work would not have been possible without the help of a great number of people. First and foremost, I would like to thank my supervisor, Simon Harvey for his extreme patience, helpful guidance and stimulating discussions and in assisting me with my PhD project and for allowing me to develop into a real scientist! Thanks to Jan Kammenga and L. Basten Snoek from Wageningen University, Netherlands for the opportunity to work with brand new panel of 4- parental recombinant inbred lines as well as N2/CB4856 RILS and nearly isogenic lines and CB4856/N2 RILs.
    [Show full text]
  • Issue 74 of the Genetics Society Newsletter
    JANUARY 2016 | ISSUE 74 GENETICS SOCIETY NEWS In this issue The Genetics Society News is edited by Manuela Marescotti and items for future • Medal awarded issues can be sent to the editor, by email • Meetings to [email protected]. • Student and Travel Reports The Newsletter is published twice a year, with copy dates of July and January. Cover image from the 2016 Genetics Society Autumn Meeting Functional genetic variation in the non-coding genome 10 – 11 November 2016, The Royal Society, London A WORD FROM THE EDITOR A word from the editor Welcome to ISSUE 74. 2016 has just begun and the ideal way Besides these two exciting articles to ease into the New Year is to take you will find a number of reports a break from the bench and to leaf written by the scientists supported through the new issue of the Genetics by the Genetics Society to organise Society newsletter with a cup of or to attend a genetics-related coffee! event. I would like to highlight In particular, you will find a very that these articles are no less topical interview granted to Kat interesting than the two mentioned Arney by Professor Alison Woollard, above. In fact, these articles upon being awarded the JBS clearly convey the enthusiasm Haldane lecture, because of her burning in you after a conference, great commitment and ability to where you had the opportunity communicate genetics. Professor to bring together scientists of the Woollard and Kat went together same field to network and build through the “genetic revolutions” up new collaborations that will mentioned by Alison during her benefit their research; or, that of a JBS Haldane lecture.
    [Show full text]
  • Issue 77 of the Genetics Society Newsletter
    2017 Genetics Society / British Society for Genetic Medicine Meeting The Human Genome in Healthcare 23 – 24 November 2017, The Royal Society, London This meeting is a joint event between the Genetics Society and the Speakers British Society for Genetic Medicine. Kaitlin Samocha Harvard Medical School/Broad Institute, USA Recent technological advances provide the ability to directly access Don Conrad Washington University School of Medicine, USA variation within an individual’s genome, providing vast potential for Joe Marsh University of Edinburgh, UK personalising and improving healthcare. The ‘Human Genome in Denis Lo Chinese University of Hong Kong, Hong Kong Healthcare’ meeting aims to explore the science that underpins current and potential future applications of the human genome to Serena Nik-Zainal Sanger Institute, UK inform diagnostics, prognostics and personalisation of therapies. Magnus Ingelman-Sundberg Karolinska Institute, Sweden Jakub Tola University of Minnesota, USA We have an outstanding line up of speakers from around the world Joe Pickrell New York Genome Centre, USA who will provide insight into the approaches through which an JULY 2017 | ISSUE 77 individual’s genome can be harnessed to improve healthcare. Sessions will focus on advances in approaches to interpret an Scientific Organisers individual’s genome in theGENETICS context of rare disease, common SOCIETYMichael Simpson King’sNEWS College London and Genomics plc complex disease and cancer, alongside approaches aiming to Jim Huggett LGC & University of Surrey provide more effective personalised therapies. In this issue Emma WoodwardThe Genetics Society Central News isManchester edited by University Hospitals NHS Lynsey Hall and items for future issues The meeting will explore how• Joint the spring impact meeting of variation within an Foundation Trust (British Society for Genetic Medicine) can be sent to the editor by email to individual’s genome is leveraged• Future frommeetings a population scale genotypic [email protected].
    [Show full text]
  • Program Abstracts COMPLETO
    C. elegans development, cell biology and gene expression 13 – 17 June 2018 | Barcelona, Spain Abstract Book meetings.embo.org/event/18-c-elegans Logo design: Ahna Skop T-shirts, mugs, bags, and other items with the Barcelona C. elegans meeting logo can be ordered online: https://www.cafepress.com/celegans/15377503 https://www.cafepress.com/celegans/15377551 2 Program & Abstract Book EMBO workshop C. elegans Development, Cell Biology & Gene Expression Combined C. elegans Topic Meeting and European C. elegans meeting June 13 - 17, 2018 Meeting Organizers • Sander van den Heuvel. Utrecht University, NL • Sophie Jarriault. IGBMC, FR • Alex Hajnal. University of Zurich, CH Co-Organizers • Julian Ceron. Bellvitge Biomedical Research Institute - IDIBELL, ES • Luisa Cochella. Research Institute of Molecular Pathology (IMP), AT • Ben Lehner. Centre for Genomic Regulation, ES Scientific Committee • Erik Anderson, Northwersten University, USA • Michael Barkoulas, Imperial College London, UK • Henrik Bringmann, Max Planck Institute for Biophysical Chemistry, DE • Olivia Casanueva, Babraham Institute, UK • Julian Ceron, Bellvitge Biomedical Research Institute-IDIBELL, ES • Barbara Conradt, Ludwig-Maximilians-Universität München, DE • Thorsten Hoppe, University of Cologne, DE • Jane Hubbard, Skirball Institute of Biomolecular Medicine, USA • Janine Kirstein, FMP Berlin, DE • Ben Lehner, Centre for Genomic Regulation, ES • Christian Pohl, Goethe-Universität Frankfurt, DE • Benjamin Podbilewicz, Technion Israel Institute of Technology, IL • Ahna Skop,
    [Show full text]
  • Biologist-Archive
    TheTHE SOCIETY OF BIOLOGY MAGAZINE ■ ISSN 0006-3347Biologist ■ SOCIETYOFBIOLOGY.ORG VOL 61 NO 2 ■ APR/MAY 2014 Our closest kin Why have we done so little to protect the great apes? TOXICOLOGY NEUROSCIENCE INTERVIEW POISON TO POTION GUIDING LIGHT DR ALISON WOOLLARD The medical potential Understanding behaviour On her Royal of arsenic with optogenetics Institution Lectures GENETICS AND GENOMICS IN MEDICINE Tom Strachan, Judith Goodship and Patrick Chinnery, all at Newcastle University, • Covers basicUK genetics relevant to health and disease • Covers basic genetics relevant to health and disease • Ex plainsJune technological 2014 • Paperback advances and • how £46.00 they are significant to medicine • CoversEx- basicplainsJune genetics technological 2014 relevant • Paperback advances to health and and • how £46.00 disease they are significant to medicine • In cludesJune500pp up-to-date 2014 • 270 • knowledge Paperbackillus • ISBN: about • the£46.00978-0-8153-4480-3 role of genetics in complex diseases • ExIn- plainscludes technologicalup-to-date knowledge advances about and how the rolethey of are genetics significant in complex to medicine diseases • Clini cal500pp disorder • boxes270 giveillus detailed • ISBN: insight 978-0-8153-4480-3 into the role of genetics in specific diseases • InClini- cludescalThis500pp disorder new up-to-date textbook • boxes270 knowledge giveillusexplains detailed • ISBN:the about scienceinsight the978-0-8153-4480-3 role intobehind ofthe genetics therole uses of geneticsin of complex genetics in specific diseases diseases • InThis cludes new pharmacogenetics textbook explains and the how science genetic behind knowledge the uses can of be genetics used in therapy and • CliniIn- calcludesand disorder genomics pharmacogenetics boxes in medicine give detailed and today.
    [Show full text]
  • Identification of Cis-Regulatory Elements from the C. Elegans T-Box
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Developmental Biology 317 (2008) 695–704 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/developmentalbiology Genomes & Developmental Control Identification of cis-regulatory elements from the C. elegans T-box gene mab-9 reveals a novel role for mab-9 in hypodermal function Peter J. Appleford, Maria Gravato-Nobre, Toby Braun, Alison Woollard ⁎ Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK article info abstract Article history: We have identified Conserved Non-coding Elements (CNEs) in the regulatory region of Caenorhabditis elegans Received for publication 8 October 2007 and Caenorhabditis briggsae mab-9, a T-box gene known to be important for cell fate specification in the Revised 14 February 2008 developing C. elegans hindgut. Two adjacent CNEs (a region 78 bp in length) are both necessary and sufficient Accepted 23 February 2008 to drive reporter gene expression in posterior hypodermal cells. The failure of a genomic mab-9∷gfp construct Available online 18 March 2008 lacking this region to express in posterior hypodermis correlates with the inability of this construct to completely rescue the mab-9 mutant phenotype. Transgenic males carrying this construct in a mab-9 mutant Keywords: background exhibit tail abnormalities including morphogenetic defects, altered tail autofluorescence and C. elegans abnormal lectin-binding properties. Hermaphrodites display reduced susceptibility to the C. elegans pathogen T-box mab-9 Microbacterium nematophilum. This comparative genomics approach has therefore revealed a previously Hypodermis unknown role for mab-9 in hypodermal function and we suggest that MAB-9 is required for the secretion and/ cis-regulation or modification of posterior cuticle.
    [Show full text]
  • Evolution of the Developmental Gene Toolkit in Caenorhabditis Elegans
    Journal of Developmental Biology Review How Weird is The Worm? Evolution of the Developmental Gene Toolkit in Caenorhabditis elegans Emily A. Baker and Alison Woollard * Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK; [email protected] * Correspondence: [email protected]; Tel.: +44-01865-613263 Received: 15 July 2019; Accepted: 25 September 2019; Published: 28 September 2019 Abstract: Comparative developmental biology and comparative genomics are the cornerstones of evolutionary developmental biology. Decades of fruitful research using nematodes have produced detailed accounts of the developmental and genomic variation in the nematode phylum. Evolutionary developmental biologists are now utilising these data as a tool with which to interrogate the evolutionary basis for the similarities and differences observed in Nematoda. Nematodes have often seemed atypical compared to the rest of the animal kingdom—from their totally lineage-dependent mode of embryogenesis to their abandonment of key toolkit genes usually deployed by bilaterians for proper development—worms are notorious rule breakers of the bilaterian handbook. However, exploring the nature of these deviations is providing answers to some of the biggest questions about the evolution of animal development. For example, why is the evolvability of each embryonic stage not the same? Why can evolution sometimes tolerate the loss of genes involved in key developmental events? Lastly, why does natural selection act to radically diverge toolkit genes in number and sequence in certain taxa? In answering these questions, insight is not only being provided about the evolution of nematodes, but of all metazoans. Keywords: gene toolkit; evo-devo; gene duplication 1.
    [Show full text]
  • Poster Presentations
    POSTER PRESENTATIONS P-000: poster session A P-000: poster session B P-000: poster session C Development P-001 NHR-40, a Caenorhabditis elegans Supplementary Nuclear Receptor Regulates the Development of Embryos and L1 Larvae E. Brozova, K. Simeckova, Z. Kostrouch and M. Kostrouchova P-002 Elucidating the Role of MicroRNAs in C. elegans Development A. Clark and E. Miska P-003 Understanding the Role of a Non-Peptidase Member of the ACE Family in Nematode Moulting H.L. Craig, C. Hunton, D.R. Brooks and R.E. Isaac P-004 RNAi Screens in C. elegans to Identify Signalling Modulators in Vulval Development C. Crombie and A. Fraser P-005 A GFP Reporter Based Screen for the Notch Target Genes during Vulval Development S. Farooqui, I. Rimann and A. Hajnal P-006 Comprehensive Analysis of Gene Expression Patterns of Hedgehog-Related Genes L. Hao, R. Johnsen, G. Lauter, D. Baillie, T.R. Bürglin P-007 GEI-16, a Putative Component of the Hemidesmosome, is Necessary for Tissue Stability and Epithelial Morphogenesis S.B. Hetherington, F.I. Pellerone, C.A. Behm P-008 Valproic Acid Affects Gene Expression and Development in Caenorhabditis elegans M. Kostrouchova, P. Liby, M. Kostrouchova and Z. Kostrouch P-009 Inhibition of bir-1, the Homologue of Human Survivin, Induces Changes of Expression of Developmentally Active Collagen Genes in L1 Larval Stage P. Liby, M. Kostrouchova, M. Pohludka, J. Vohanka, E. Brozova, M. Kostrouchova and Z. Kostrouch P-010 NHR-25 Role in the Seam Cell Differentiation in C. elegans M. Machackova, M. Silhankova, M. Jindra and M.
    [Show full text]