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The Buddha's Wager by Piya Tan
Revisioning Buddhism ©Piya Tan, 2017 The Buddha’s wager1 The Buddha always holds the Dharma first, as evident from the Gārava Sutta (S 6.2),2 which records one of the first key events in the Buddha’s life after the great awakening. In the Mahā,- parinibbāna Sutta (D 16),3 which records his last moments, too, the Buddha declares that the Dharma comes first, before the teacher. However, against the Buddha’s clear instructions, other Buddhist sectarians and later teachers put their Sutras and Teachings first. Such disregard from the Buddha arises from various reasons and conditions, but basically it was (and is) on account of desire for worldly gains and following, for putting down rivalry and dissent, and the influence of worldly conditions and other religions. The Buddha does not make such vital statements frivolously or as an option that we may dis- regard. He has very good reasons for giving us such initial and final instructions. To remind ourselves of the vitality of these instructions we will call them the “Buddha’s wager.” This wager or challenge can be simply put like this: The Buddha holds Dharma above himself. Buddha or no Buddha, Dharma is always there. The later sectarian Buddhist teachers place their Sutras and Teachings first. Without these gurus’ Sutras and Teachings, there are no later Buddhist sects. We don’t need the later Buddhist sects, and can and must go directly to the Dharma. Here, I think, is an almost infallible test for the authenticity of the historical Buddha’s teaching or the Buddha Dharma, the teaching of awakening. -
The Role of Puñña and Kusala in the Dialectic of the Twofold Right Vision and the Temporary Integration of Eternalism in the P
The Role of puñña and kusala in the Dialectic of the Twofold Right Vision and the Temporary Integration of Eternalism in the Path Towards Spiritual Emancipation According to the Pāli Nikāya s Krishna Del Toso Esercizi Filosofici 3, 2008, pp. 32-58 ISSN 1970-0164 THE ROLE OF PUÑÑA AND KUSALA IN THE DIALECTIC OF THE TWOFOLD RIGHT VISION AND THE TEMPORARY INTEGRATION OF ETERNALISM IN THE PATH TOWARDS SPIRITUAL EMANCIPATION ∗ ACCORDING TO THE PĀLI NIKĀYA S Krishna Del Toso …a motto adopted from one of Salvor Hardin’s epigrams, “ever let your sense of morals prevent you from doing what is right!” Isaac Asimov 1 Abstract : This article shows how in the Pāli Nikāya s, after having defined Eternalism and Nihilism as two opposed positions, Gotama makes a dialectical use of Eternalism as means to eliminate Nihilism, upheld to be the worst point of view because of its denial of kammic maturation in terms of puñña and pāpa . Assuming, from an Eternalist perspective, that actions have effects also beyond the present life, Gotama underlines the necessity of betting on the validity of moral kammic retribution. Having thus demonstrated the central ethical error of Nihilism, he subtly introduces peculiar Buddhist moral concepts ( kusala/akusala ) to purify the Eternalist vision from the doctrine of a real existing self ( attāvāda ) and from the puñña /pāpa dichotomy. We can summarize this dialectical course as follows: Nihilism is pāpa /akusala because it denies kamman , Eternalism is puñña /not-akusala because it upholds kamman from a non-Buddhist perspective, Buddhism is kusala because it admits the law of kamman not centered on a theory of a real existing self (anattāvāda ). -
USA Education Ph.D., Biology, Massachusetts Institute of Tech
Victor R. Ambros, Ph.D. Silverman Professor of Natural Sciences Program in Molecular Medicine University of Massachusetts Medical School373 Plantation Street, Suite 306 Worcester, MA 01605 (508) 856-6380 [email protected] Personal Born: Hanover, NH, USA on December 1, 1953 Citizenship: USA Education Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA 1976-1979 Thesis Title: The protein covalently linked to the 5' end of poliovirus RNA Advisor: Dr. David Baltimore B.S., Biology, Massachusetts Institute of Technology, Cambridge, MA 1971-1975 Professional Appointments Silverman Professor of Natural Sciences 2009-present Co-Director, RNA Therapeutics Institute 2009-2016 Professor, Program in Molecular Medicine 2008-present University of Massachusetts Medical School, Worcester, MA Professor of Genetics, Dartmouth Medical School 2001-2007 Professor, Biological Sciences, Dartmouth Medical School 1996-2001 Associate Professor, Biological Sciences, Dartmouth Medical School 1992-1996 Associate Professor, Department of Cellular and Development Biology, 1988-1992 Harvard University, Cambridge, MA Assistant Professor, Department of Cellular and Development Biology, 1985-1988 Harvard University, Cambridge, MA Postdoctoral Research 1979-1985 Supervisor: Dr. H. Robert Horvitz Massachusetts Institute of Technology, Cambridge, MA Graduate Research 1976-1979 Supervisor: Dr. David Baltimore Massachusetts Institute of Technology, Cambridge, MA Research Assistant 1975-1976 Supervisor: Dr. David Baltimore Center for Cancer Research, -
Prince of Legend Free
FREE PRINCE OF LEGEND PDF Jack Ludlow | 320 pages | 15 Apr 2014 | ALLISON & BUSBY | 9780749015626 | English | London, United Kingdom Prince of Legend (TV Mini-Series ) - IMDb From " Veronica Mars " to Rebecca take a look back at the career of Armie Hammer on and off the screen. See the full gallery. Kanade and Takato who live in completely different worlds and have totally opposite personality start to compete for an important thing. Looking for something to watch? Choose an adventure below and discover your Prince of Legend favorite movie or TV show. Visit our What to Watch page. Sign In. Keep track of everything you watch; tell your friends. Full Cast and Crew. Release Dates. Official Sites. Company Credits. Technical Specs. Episode List. Plot Summary. Plot Keywords. Parents Guide. External Sites. User Reviews. User Ratings. External Reviews. Metacritic Reviews. Photo Gallery. Trailers and Videos. Crazy Credits. Alternate Versions. Rate This. Episode Guide. Added to Watchlist. The Evolution of Armie Hammer. Japanese drama. Share this Rating Title: Prince of Legend 5. Use the HTML below. You must be a registered user to use Prince of Legend IMDb rating plugin. Episodes Seasons. Photos Add Image Add an image Do you have any images for this title? Sho 10 episodes, Itsuki Fujiwara Kaiji Hiura 10 episodes, Makoto Hasegawa Riku Odajima 10 episodes, Hiroki Iijima Mitsuhiko Jissoji 10 episodes, Kazuma Kawamura Haru Sagasawa 10 Prince of Legend, Taichi Kodama Taichi 10 episodes, Keita Machida Riichi Yuki 10 Prince of Legend, Seiji Rokkaku Toshiya Suzaku 10 episodes, Reo Sano Aoi Ayanokoji 10 episodes, Mandy Sekiguchi Gabriel Sasazuka 10 episodes, Akihisa Shiono Yuta Hattori 10 episodes, Hokuto Yoshino Edit Storyline Kanade and Takato who live in completely different worlds and have totally opposite personality start to compete for an important thing. -
Distinctive Regulatory Architectures of Germline-Active and Somatic Genes in C
Downloaded from genome.cshlp.org on October 7, 2021 - Published by Cold Spring Harbor Laboratory Press Research Distinctive regulatory architectures of germline-active and somatic genes in C. elegans Jacques Serizay, Yan Dong, Jürgen Jänes, Michael Chesney, Chiara Cerrato, and Julie Ahringer The Gurdon Institute and Department of Genetics, University of Cambridge, CB2 1QN Cambridge, United Kingdom RNA profiling has provided increasingly detailed knowledge of gene expression patterns, yet the different regulatory ar- chitectures that drive them are not well understood. To address this, we profiled and compared transcriptional and regu- latory element activities across five tissues of Caenorhabditis elegans, covering ∼90% of cells. We find that the majority of promoters and enhancers have tissue-specific accessibility, and we discover regulatory grammars associated with ubiquitous, germline, and somatic tissue–specific gene expression patterns. In addition, we find that germline-active and soma-specific promoters have distinct features. Germline-active promoters have well-positioned +1 and −1 nucleosomes associated with a periodic 10-bp WW signal (W = A/T). Somatic tissue–specific promoters lack positioned nucleosomes and this signal, have wide nucleosome-depleted regions, and are more enriched for core promoter elements, which largely differ between tissues. We observe the 10-bp periodic WW signal at ubiquitous promoters in other animals, suggesting it is an ancient conserved signal. Our results show fundamental differences in regulatory architectures of germline and somatic tissue–specific genes, uncover regulatory rules for generating diverse gene expression patterns, and provide a tissue-specific resource for future studies. [Supplemental material is available for this article.] Cell type–specific transcription regulation underlies production tissues are achieved and whether expression is governed by dis- of the myriad of different cells generated during development. -
Download Program Guide
2011 C. elegans Meeting Organizing Committee Co-chairs: Oliver Hobert Columbia University Meera Sundaram University of Pennsylvania Organizing Committee: Raffi Aroian University of California, San Diego Ikue Mori Nagoya University Jean-Louis Bessereau INSERM Benjamin Podbilewicz Technion Israel Institute of Keith Blackwell Harvard Medical School Technology Andrew Chisholm University of California, San Diego Valerie Reinke Yale University Barbara Conradt Dartmouth Medical School Janet Richmond University of Illinois, Chicago Marie Anne Felix CNRS-Institut Jacques Monod Ann Rougvie University of Minnesota David Greenstein University of Minnesota Shai Shaham Rockefeller University Alla Grishok Columbia University Ahna Skop University of Wisconsin, Madison Craig Hunter Harvard University Ralf Sommer Max-Planck Institute for Bill Kelly Emory University Developmental Biology, Tuebingen Ed Kipreos University of Georgia Asako Sugimoto RIKEN, Kobe Todd Lamitina University of Pennsylvania Heidi Tissenbaum University of Massachusetts Chris Li City College of New York Medical School Sponsored by The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 telephone: (301) 634-7300 fax: (301) 634-7079 e-mail: [email protected] Web site: http:/www.genetics-gsa.org Front cover design courtesy of Ahna Skop 1 Table of Contents Schedule of All Events.....................................................................................................................4 Maps University of California, Los Angeles, Campus .....................................................................7 -
Caenorhabditis Microbiota: Worm Guts Get Populated Laura C
Clark and Hodgkin BMC Biology (2016) 14:37 DOI 10.1186/s12915-016-0260-7 COMMENTARY Open Access Caenorhabditis microbiota: worm guts get populated Laura C. Clark and Jonathan Hodgkin* Please see related Research article: The native microbiome of the nematode Caenorhabditis elegans: Gateway to a new host-microbiome model, http://dx.doi.org/10.1186/s12915-016-0258-1 effects on the life history of the worm are often profound Abstract [2]. It has been increasingly recognized that the worm Until recently, almost nothing has been known about microbiota is an important consideration in achieving a the natural microbiota of the model nematode naturalistic experimental model in which to study, for Caenorhabditis elegans. Reporting their research in instance, host–pathogen interactions or worm behavior. BMC Biology, Dirksen and colleagues describe the first Dirksen et al [3] present the first step towards under- sequencing effort to characterize the gut microbiota standing understanding the complex interactions of the of environmentally isolated C. elegans and the related natural worm microbiota by reporting a 16S rDNA-based taxa Caenorhabditis briggsae and Caenorhabditis “head count” of the bacterial population present in wild remanei In contrast to the monoxenic, microbiota-free nematode isolates (Fig. 1). Interestingly, it appears that cultures that are studied in hundreds of laboratories, it nematodes isolated from diverse natural environment- appears that natural populations of Caenorhabditis s—and even those that have been maintained for a short harbor distinct microbiotas. time on E. coli following isolation—share a “core” host- defined microbiota. This finding is in agreement with work by Berg et al. -
Gurdon Institute 20122011 PROSPECTUS / ANNUAL REPORT 20112010
The Wellcome Trust/Cancer Research UK Gurdon Institute 20122011 PROSPECTUS / ANNUAL REPORT 20112010 Gurdon I N S T I T U T E PROSPECTUS 2012 ANNUAL REPORT 2011 http://www.gurdon.cam.ac.uk CONTENTS THE INSTITUTE IN 2011 INTRODUCTION........................................................................................................................................3 HISTORICAL BACKGROUND..........................................................................................................4 CENTRAL SUPPORT SERVICES....................................................................................................5 FUNDING.........................................................................................................................................................5 RETREAT............................................................................................................................................................5 RESEARCH GROUPS.........................................................................................................6 MEMBERS OF THE INSTITUTE................................................................................44 CATEGORIES OF APPOINTMENT..............................................................................44 POSTGRADUATE OPPORTUNITIES..........................................................................44 SENIOR GROUP LEADERS.............................................................................................44 GROUP LEADERS.......................................................................................................................48 -
Sumoylation Regulates Protein Dynamics During Meiotic Chromosome Segregation in C
© 2019. Published by The Company of Biologists Ltd | Journal of Cell Science (2019) 132, jcs232330. doi:10.1242/jcs.232330 RESEARCH ARTICLE Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes Federico Pelisch*, Laura Bel Borja, Ellis G. Jaffray and Ronald T. Hay ABSTRACT studies of MT-dependent chromosome movement focused on Oocyte meiotic spindles in most species lack centrosomes and pulling forces generated by kinetochore MTs (kMTs) making the mechanisms that underlie faithful chromosome segregation end-on contacts with chromosomes (Cheeseman, 2014), there is in acentrosomal meiotic spindles are not well understood. In also evidence for pushing forces that are exerted on the segregating C. elegans oocytes, spindle microtubules exert a poleward force on chromosomes (Khodjakov et al., 2004; Nahaboo et al., 2015; š ́ chromosomes that is dependent on the microtubule-stabilising Laband et al., 2017; Vuku ic et al., 2017; Yu et al., 2019 preprint). protein CLS-2, the orthologue of the mammalian CLASP proteins. The nematode Caenorhabditis elegans contains holocentric The checkpoint kinase BUB-1 and CLS-2 localise in the central chromosomes (Maddox et al., 2004) and has served as an spindle and display a dynamic localisation pattern throughout extremely useful system to uncover mechanisms of meiosis and anaphase, but the signals regulating their anaphase-specific mitosis for almost 20 years (Oegema et al., 2001; Desai et al., 2003; localisation remains unknown. We have shown previously that Cheeseman et al., 2004, 2005; Monen et al., 2005). Meiosis is a SUMO regulates BUB-1 localisation during metaphase I. Here, we specialised cell division with two successive rounds of chromosome found that SUMO modification of BUB-1 is regulated by the SUMO E3 segregation that reduce the ploidy and generates haploid gametes ligase GEI-17 and the SUMO protease ULP-1. -
Transcriptomic Description of an Endogenous Female State in C
bioRxiv preprint first posted online Oct. 27, 2016; doi: http://dx.doi.org/10.1101/083113. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. Transcriptomic Description of an Endogenous Female State in C. elegans David Angeles-Albores1,y Daniel H.W. Leighton2,y Tiffany Tsou1 Tiffany H. Khaw1 Igor Antoshechkin3 Paul W. Sternberg1,* October 29, 2016 y These authors contributed equally to this work 1 Department of Biology and Biological Engineering, and Howard Hughes Medical Institute, Caltech, Pasadena, CA, 91125, USA 2 Department of Human Genetics, Department of Biological Chemistry, and Howard Hughes Medical Insti- tute, University of California, Los Angeles, Los Angeles, CA 90095, USA 3 Department of Biology and Biological Engineering, Caltech, Pasadena, CA, 91125, USA * Corresponding author. Contact:[email protected] Abstract Understanding genome and gene function in a whole organism requires us to fully compre- hend the life cycle and the physiology of the organism in question. Although C. elegans is traditionally though of as a hermaphrodite, XX animals exhaust their sperm and become (en- dogenous) females after 3 days of egg-laying. The molecular physiology of this state has not been studied as intensely as other parts of the life cycle, in spite of documented changes in behavior and metabolism that occur at this stage. To study the female state of C. elegans, we designed an experiment to measure the transcriptomes of 1st day adult females; endoge- nous, 6th day adult females; and at the same time points, mutant feminized worms. -
Profile of Gary Ruvkun
PROFILE Profile of Gary Ruvkun wash in the faint glow of a fluo- Brush with Molecular Biology rescent lamp, a pair of serpentine The story of Ruvkun’s metamorphosis Anematode worms lie on a Petri from a keen undergraduate into a leading plate, their see-through bodies light in his field of study begins at Har- magnified 100-fold by one of several vard University, where he enrolled in microscopes arrayed in a darkened bay in a Ph.D. program in 1976 upon returning National Academy of Sciences member to the United States. Like many other Gary Ruvkun’s laboratory at Massachu- scientific institutions across the world in setts General Hospital. While one of the the mid-1970s, Harvard was astir with the worms wiggles its way around the plate, promise of recombinant DNA technol- the other shows no signs of life, ogy, and Ruvkun wasted no time em- its midsection ruptured and its innards bracing its tools. “My undergraduate strewn asunder. A filter slides into place, education had not prepared me at all for and the worms are bathed in a dull recombinant DNA, but I immersed my- green haze. The wiggling worm has a bea- self into its culture at Harvard, much of con of nerve cells in its head, the ganglia which was James Watson’s creation from lit up by a genetic trick that has rescued a decade earlier,” Ruvkun says. Propelled the worm from death; its neighbor wears Gary Ruvkun. by a desire to be a part of the culture of no such beacon. The worms were deprived basic molecular biology, all while per- of a tiny RNA molecule, called a micro- forming science with the potential to im- RNA, which helps shepherd them through not 5-year-old children. -
Geidai Arts Summit 2012 from Asia to the World －The Development and Cooperation－
GEIDAI ARTS SUMMIT 2012 FROM ASIA TO THE WORLD －THE DEVELOPMENT AND COOPERATION－ 10/10/2012 Tokyo University of the Arts 参加大学 Univerity Invited Central Academy of Fine Arts 中央美術学院 Central Conservatory of Music 中央音楽学院 Academy of Arts & Design, Tsinghua University 清華大学美術学院 Shanghai Conservatory of Music 上海音楽学院 China Academy of Art 中国美術学院 Xinjiang Arts Institute 新疆芸術学院 Shanghai Institute of Visual Art, Fudan University 復旦大学上海視覚芸術学院 Tainan National University of the Arts 台南芸術大学 National Taiwan University of Arts 台湾芸術大学 Taipei National University of the Arts 台北芸術大学 College of Fine Arts, Seoul National University ソウル大学校美術大学 College of Music, Seoul National University ソウル大学校音楽大学 Korea National University of Arts 韓国芸術綜合学校 Daegu University 大邱大学校 Korean Academy of Film Arts 韓国映画アカデミー Korea National University of Cultural Heritage 韓國傳統文化大學校 Mongolian State University of Arts and Culture モンゴル国立文化芸術大学 Institut Seni Indonesia Yogyakarta インドネシア芸術大学ジョグジャカルタ校 Institut Seni Indonesia Denpasar インドネシア芸術大学デンパサール校 Vietnam University of Fine Arts ベトナム美術大学 Ho Chi Minh City University of Fine Arts ホーチミン市美術大学 Vietnam National Academy of Music ベトナム国家音楽学院 Silpakorn University シラパコーン大学 LASALLE College of the Arts ラサール芸術大学 National Academy of Arts, Culture & Heritage 国立芸術文化遺産大学 Aichi Prefectural University of Fine Arts and Music 愛知県立芸術大学 Okinawa Prefectural University of Arts 沖縄県立芸術大学 Kanazawa College of Art 金沢美術工芸大学 Kyoto City University of Arts 京都市立芸術大学 Tokyo University of the Arts 東京藝術大学 86 GEIDAI ARTS SUMMIT 2012 Contents 89 President’s Foreword 90 Schedule of