Issue 77 of the Genetics Society Newsletter
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SM08 Programme
SATELLITE MEETING Regulation of gene expression from a distance: exploring mechanisms The Royal Society at Chicheley Hall, home of the Kavli Royal Society International Centre Organised by Professor Wendy Bickmore and Professor Veronica van Heyningen FRS Wednesday 24 – Thursday 25 October 2012 DAY 1 DAY 2 SESSION 1 SESSION 2 SESSION 3 SESSION 4 Enhancer assays Quantitative and dynamic analysis Quantitative & dynamic analysis of Defining enhancers and their mechanisms – transgenes, genetics, and interactomes of transcription protein binding at regulatory of action Chair: Professor Nick Hastie CBE FRS Chair: elements Chair: Dr Duncan Odom Welcome by RS & lead 09.00 Professor Anne Ferguson-Smith Chair: Professor Constance Bonifer organiser The evolution of global Dynamic use of enhancers in Design rules for bacterial Massively parallel functional 09.05 enhancers 13.30 development 09.00 enhancers 13.15 dissection of mammalian enhancers Professor Denis Duboule Professor Mike Levine Dr Roee Amit Dr Rupali Patwardhan 09.30 Discussion 14.00 Discussion 09.30 Discussion 13.45 Discussion Complex protein dynamics at HERC2 rs12913832 modulates The pluripotent 3D genome Gene expression genomics eukaryotic regulatory human pigmentation by attenuating 09.45 14.15 09.45 Professor Wouter de Laat Dr Sarah Teichmann elements chromatin-loop formation between a 14.00 Dr Gordon Hager long-range enhancer and the OCA2 promoter 10.15 Discussion 14.45 Discussion 10.15 Discussion Dr Robert-Jan Palstra 10.30 Coffee 15.00 Tea 10.30 Coffee 14.15 Tea Maps of open chromatin -
The Story of a Rising Race
This is a reproduction of a library book that was digitized by Google as part of an ongoing effort to preserve the information in books and make it universally accessible. https://books.google.com Thestoryofarisingrace JamesJeffersonPipkin COUNCIIA.W.H. SOMENOTEDEDUCATORSOFRACE.THECOLORED T.WASHINGTON.BOOKER WESLHYHOFFMAN.JOHN THE STORY OF A RISING RACE THE NEGRO IN REVELATION, IN HISTORY AND IN CITIZENSHIP WHAT THE RACE HAS DONE AND IS DOING ARMS, ARTS, LETTERS, THE PULPIT, THE FORUM, THE SCHOOL, THE MARTS OF TRADE WITH THOSE MIGHTY WEAPONS IN THE BATTLE OF LIFE THE SHOVEL AND THE HOE A MESSAGE TO ALL MEN THAT HE IS IN THE WAY TO SOLVE THE RACE PROBLEM EOR HIMSELF REV. J . J . WPKIK WITH INTRODUCTION BY GEN. JOHN B. GORDON Former Major-General Confederate Army, United States Senator from Georgia. Ex-Commander United Confederate Veterans, Author "War Reminiscences," Etc. ^ CatJogua Proe. (JOPYHTUHT, 1902, BY N. ]).THOMP»ON PUBLISHING OOMPAN V NOT A TERM OF REPROACH. Supposing that this term (negro) was originally used as a phrase of contempt, is it not wilh us to elevate it? How often has it not happened that names originally given in reproach have been afterward adopted as a title of honor by those against whom they were used, as Methodists, Quakers, etc. t But as a proof that no unfavorable signification attached to the word when first employed, I may mention that long before the slave trade began travelers found the blacks on the coast of Africa preferring to be called Negroes. And in all the pre- slave trade literature the word was spelled with a capital N. -
Gene Expression Studies: from Case-Control to Multiple-Population-Based Studies
From the Institute of Human Genetics, Helmholtz Zentrum Munchen,¨ Deutsches Forschungszentrum fur¨ Gesundheit und Umwelt (GmbH) Head: Prof. Dr. Thomas Meitinger Gene expression studies: From case-control to multiple-population-based studies Thesis Submitted for a Doctoral Degree in Natural Sciences at the Faculty of Medicine, Ludwig-Maximilians-Universitat¨ Munchen¨ Katharina Schramm Dachau, Germany 2016 With approval of the Faculty of Medicine Ludwig-Maximilians-Universit¨atM ¨unchen Supervisor/Examiner: Prof. Dr. Thomas Illig Co-Examiners: Prof. Dr. Roland Kappler Dean: Prof. Dr. med. dent. Reinhard Hickel Date of oral examination: 22.12.2016 II Dedicated to my family. III Abstract Recent technological developments allow genome-wide scans of gene expression levels. The reduction of costs and increasing parallelization of processing enable the quantification of 47,000 transcripts in up to twelve samples on a single microarray. Thereby the data collec- tion of large population-based studies was improved. During my PhD, I first developed a workflow for the statistical analyses of case-control stu- dies of up to 50 samples. With large population-based data sets generated I established a pipeline for quality control, data preprocessing and correction for confounders, which re- sulted in substantially improved data. In total, I processed more than 3,000 genome-wide expression profiles using the generated pipeline. With 993 whole blood samples from the population-based KORA (Cooperative Health Research in the Region of Augsburg) study we established one of the largest population-based resource. Using this data set we contributed to a number of transcriptome-wide association studies within national (MetaXpress) and international (CHARGE) consortia. -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
Expression of the Short Stature Homeobox Gene Shox Is Restricted by Proximal and Distal Signals in Chick Limb Buds and Affects the Length of Skeletal Elements
Developmental Biology 298 (2006) 585–596 www.elsevier.com/locate/ydbio Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements Eva Tiecke a, Fiona Bangs a, Rudiger Blaschke b, Elizabeth R. Farrell a, ⁎ Gudrun Rappold b, Cheryll Tickle a, a Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK b Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, D-69120 Heidelberg, Germany Received for publication 6 June 2006; accepted 10 July 2006 Available online 12 July 2006 Abstract SHOX is a homeobox-containing gene, highly conserved among species as diverse as fish, chicken and humans. SHOX gene mutations have been shown to cause idiopathic short stature and skeletal malformations frequently observed in human patients with Turner, Leri–Weill and Langer syndromes. We cloned the chicken orthologue of SHOX, studied its expression pattern and compared this with expression of the highly related Shox2. Shox is expressed in central regions of early chick limb buds and proximal two thirds of later limbs, whereas Shox2 is expressed more posteriorly in the proximal third of the limb bud. Shox expression is inhibited distally by signals from the apical ectodermal ridge, both Fgfs and Bmps, and proximally by retinoic acid signaling. We tested Shox functions by overexpression in embryos and micromass cultures. Shox- infected chick limbs had normal proximo-distal patterning but the length of skeletal elements was consistently increased. Primary chick limb bud cell cultures infected with Shox showed an initial increase in cartilage nodules but these did not enlarge. -
EMBC Annual Report 2007
EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation -
Principles of Development Lewis Wolpert
Principles of development lewis wolpert Continue The process of biological development is an amazing feat of tightly regulated cellular behavior - differentiation, movement and growth - powerful enough to lead to the appearance of a very complex living organism from a single cell, a fertilized egg. The principles of development clearly illustrate the universal principles governing this development process in a concise and accessible style. Written by two respected and influential development biologists, Lewis Volpert and Sheryl Tickle, it focuses on the systems that best illuminate the general principles covered by the text and avoids suppressing the reader with encyclopedic details. With co-authors whose experience spans discipline, The Principles of Development combines the careful study of the subject with ideas from some of the world's pioneers of research in development biology, guiding the student from the basics to the latest discoveries in the field. The Internet Resource Center Internet Resource Center to accompany the Principles of Development features For registered adopters of text: Electronic works of art: Figures from the book are available for download, for use in lectures. Journal Club: Proposed scientific papers and discussion related to the topics presented in the book direct the process of learning from the scientific literature. PowerPoint numbers: Figures inserted into PowerPoint for use in handouts and presentations. For students: Web links and web activities: Recommended websites related to each chapter guide students to further sources of information each accompanied by a brief overview of how the source can help with their research and thought issue to help think about the underlying issues. -
Written Evidence Submitted by the MRC Human Genetics Unit at The
Written evidence submitted by the MRC Human Genetics Unit at the University of Edinburgh and the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee (USC0001) We write in response to the UK Parliament Scottish Affairs Committee’s Call for Evidence in relation to Universities and Scotland. Our evidence pertains to “How Scottish university research fits in with UK university research”. We write as the directors of two UKRI Medical Research Council (MRC) Units based in Scottish Universities; the MRC Human Genetics Unit at the University of Edinburgh (https://www.ed.ac.uk/mrc-human-genetics-unit) and the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee (https://www.ppu.mrc.ac.uk). As part of UKRI, the MRC invests 40% of its annual budget on an intramural portfolio of institutes, units and centres. MRC Units are long term investments that tackle important, often high risk, research questions that cannot be addressed adequately through short-term response-mode grant funding. MRC Units develop new methods and research facilities, foster interdisciplinarity, and spearhead training of the next generation of research leaders. Most MRC Units are embedded within universities (MRC University Units) and, because of the scale and sustainability of their research funding - reviewed and renewed every 5 years, they have a major impact on the research landscape of the universities that they are embedded in, including in Scotland. The scale and quality of research funded in MRC Units greatly enhances academic leadership within the host university as well as the Research Excellence Grant (REG) income that the host university receives from the Scottish Funding Council. -
Lectures and Seminars, Michaelmas Term 2014
WEDNESDay 8 octobEr 2014 • SUPPLEMENt (1) to No 5071 • VoL 145 Gazette Supplement Lectures and Seminars, Michaelmas term 2014 Romanes Lecture 26 Pharmacology, anatomical reuters Institute for the Study of Neuropharmacology and Drug Journalism Discovery Seminars Latin american centre Charles Simonyi Lecture 26 Physiology, anatomy and Genetics Foundation for Law, Justice and Society Population Health Maison Française Humanities 26 Psychiatry oxford Martin School Museum of Natural History TORCH | The Oxford Research Centre in Social Sciences 35 the Humanities Population ageing Classics anthropology and Museum Ethnography Ian ramsey centre English Language and Literature Archaeology Rhodes House English /History/History of Art/Theology/ Education McDonald centre for theology, Ethics and Public Life Music International Development (Queen History Elizabeth House) Colleges, Halls and Societies 47 History of Art Internet Institute Linguistics, Philology and Phonetics Law All Souls Medieval and Modern Languages Politics and International relations Green templeton Music Social Policy and Intervention Keble Oriental Studies Socio-legal Studies Kellogg Philosophy Sociology Mansfield Theology and Religion Nuffield Department for Continuing St Antony’s Education 40 Mathematical, Physical and St Catherine’s Life Sciences 32 Kellogg college centre for creative St Edmund Hall Chemistry Writing St Hilda’s Earth Sciences St John’s Institutes, Centres and Engineering Science Somerville Museums 41 e-Research Centre University college Materials ashmolean Museum -
Science and Stormont Monday 10 October 2016 Antimicrobial Resistance
Science and Stormont Monday 10 October 2016 Antimicrobial Resistance Programme Senate Chamber & the Long Gallery, Parliament Buildings, Stormont 12:30pm : Registrations, exhibition & light refreshments 3:45pm : TEA BREAK The Long Gallery 4:15pm : Panel two 1:45pm : Proceed to the Senate Chamber for the Afternoon Tackling Antimicrobial Resistance - Presentations A Multidisciplinary Approach 2:00pm : Opening Address Dr Patrick Dunlop, Lecturer in Engineering Naomi Long MLA, Chair, Northern Ireland Materials (NIBEC), Ulster University and Chair NI Assembly All-Party Group on Science and AMR Network Technology Natural alternatives to antibiotics Prof Paul Ross, Head of College of Science 2:05pm : Welcome and introduction Engineering and Food Science, University College Prof Sir John Holman, President, Royal Society of Cork Chemistry Tackling AMR, an Industry Perspective 2:15pm : Together against the bugs: scientific and political Dr Robert Grundy, Co-Chair Life and Health leadership on a mission Sciences, Department for the Economy’s MATRIX Dr Michael McBride, Chief Medical Officer, panel Northern Ireland 5:15pm : MLA Panel 2:40pm : Session Chair Naomi Long MLA, Chair, Northern Ireland Dr Geetha Srinivasan, Queen’s University Belfast, Assembly All-Party Group on STEM and member, Royal Society of Chemistry Steve Aiken OBE MLA, Vice Chair, All-Party Group 2:45pm : Panel one on STEM Antibiotic use in care homes Caoimhe Archibald MLA, Vice Chair, All-Party Prof Michael Tunney, Chair in Clinical Pharmacy, Group on STEM School of Pharmacy, Queen’s -
100 Years of Genetics
Heredity (2019) 123:1–3 https://doi.org/10.1038/s41437-019-0230-2 EDITORIAL 100 years of genetics Alison Woollard1 Received: 27 April 2019 / Accepted: 28 April 2019 © The Genetics Society 2019 The UK Genetics Society was founded on 25 June 1919 and “biometricians”; the Genetical Society was very much a this special issue of Heredity, a journal owned by the society of Mendelians. Remarkably, 16 of the original 87 Society, celebrates a century of genetics from the perspec- members were women—virtually unknown in scientific tives of nine past (and present) presidents. societies at the time. Saunders was a vice president from its The founding of the Genetical Society (as it was then beginning and its 4th president from 1936–1938. Perhaps known) is often attributed to William Bateson, although it the new, and somewhat radical, ideas of “genetics” pre- was actually the brain child of Edith Saunders. The enthu- sented a rare opportunity for women to engage in research siasm of Saunders to set up a genetics association is cited in because the field lacked recognition in universities, and was the anonymous 1916 report “Botany at the British Asso- therefore less attractive to men. 1234567890();,: 1234567890();,: ciation”, Nature, 98, 2456, p. 238. Furthermore, the actual Bateson and Saunders (along with Punnett) were also founding of the Society in 1919 “largely through the energy influential in the field of linkage analysis (“partial coupling” as of Miss E.R Saunders” is reported (anonymously) in they referred to it at the time), having made several observa- “Notes”, Nature, 103, 2596, p. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work.