SATELLITE MEETING Regulation of expression from a distance: exploring mechanisms The Royal Society at Chicheley Hall, home of the Kavli Royal Society International Centre Organised by Professor Wendy Bickmore and Professor Veronica van Heyningen FRS Wednesday 24 – Thursday 25 October 2012

DAY 1 DAY 2 SESSION 1 SESSION 2 SESSION 3 SESSION 4 Enhancer assays Quantitative and dynamic analysis Quantitative & dynamic analysis of Defining enhancers and their mechanisms – transgenes, , and interactomes of protein binding at regulatory of action Chair: Professor Nick Hastie CBE FRS Chair: elements Chair: Dr Duncan Odom Welcome by RS & lead 09.00 Professor Anne Ferguson-Smith Chair: Professor Constance Bonifer organiser The of global Dynamic use of enhancers in Design rules for bacterial Massively parallel functional 09.05 enhancers 13.30 development 09.00 enhancers 13.15 dissection of mammalian enhancers Professor Denis Duboule Professor Mike Levine Dr Roee Amit Dr Rupali Patwardhan 09.30 Discussion 14.00 Discussion 09.30 Discussion 13.45 Discussion Complex protein dynamics at HERC2 rs12913832 modulates The pluripotent 3D eukaryotic regulatory human pigmentation by attenuating 09.45 14.15 09.45 Professor Wouter de Laat Dr Sarah Teichmann elements chromatin-loop formation between a 14.00 Dr Gordon Hager long-range enhancer and the OCA2 promoter 10.15 Discussion 14.45 Discussion 10.15 Discussion Dr Robert-Jan Palstra 10.30 Coffee 15.00 Tea 10.30 Coffee 14.15 Tea Maps of open chromatin from Exploring gene expression at Transcription factors and DNA Variant enhancer loci in 11.00 association signals to function 15.30 the single cell level 11.00 regulatory elements 14.45 Dr Peter Scacheri Dr Panos Deloukas Dr Jon Chubb Dr Martha Bulyk 11.30 Discussion 16.00 Discussion 11.30 Discussion 15.15 Discussion Transcription factor search Controlling long-range Deciphering the cis -regulatory kinetics explored at the level genomic interactions to 11.45 code 16.15 11.45 15.30 Panel discussion of single molecules reprogram the β-globin locus Dr Eileen Furlong Dr Johann Elf Dr Gerd Blobel 12.15 Discussion 16.45 Discussion 12.15 Discussion 16.00 CLOSE 12.30 LUNCH 17.00 CLOSE 12.30 LUNCH