Wednesday 26 OCTOBER Thursday 27 OCTOBER

11:00 Maria Leptin Welcome address 08:25 Bus from Villa Toskana Hotel 08:30 Bus from ISG Hotel SESSION 1 Suzanne Eaton CHAIR Max Planck Institute of Molecular Cell Biology & Genetics, Dresden, DE 08:30 – 09:00 COFFEE BREAK EMBL OPERON FOYER 11:10 Helder Maiato Cracking the code of mitosis University of Porto, PT SESSION 5 Michael Way CHAIR The Francis Crick Institute, London, GB 11:30 Eugene Myers A forward-looking vision for microscopy and image analysis 09:00 Buzz Baum Cell division: its origins and mechanics Max Planck Institute of Molecular Cell Biology & Genetics, Dresden, DE University College London, GB 11:50 Adam Antebi Convergent mechanisms of longevity 09:20 Pekka Lappalainen Assembly of mechanosensitive actomyosin bundles in migrating cells Max Planck Institute for Biology of Ageing, Cologne, DE University of Helsinki, FI 12:10 Uwe Sauer Coordination of metabolism 09:40 Carsten Janke The tubulin code – generating signals to control microtubule function ETH Zurich, CH Institut Curie, Orsay, FR 12:30 Ehud Gazit Metabolite amyloids: a new paradigm for inborn error of metabolism 10:00 Carl-Philipp Heisenberg Cell and tissue mechanics in zebrafish gastrulation disorders Institute of Science and Technology Austria, Klosterneuburg, AT Tel Aviv University, IL 10:20 Erik Sahai Modelling lethal cancer phenotypes 12:50 – 13:20 LUNCH EMBL OPERON FOYER The Francis Crick Institute, London, GB

SESSION 2 Javier Paz-Ares CHAIR Universidad Autónoma de Madrid, ES 10:40 – 11:00 COFFEE BREAK EMBL OPERON FOYER

13:20 Simona Polo Ubiquitin signaling in cancer and neurodegeneration SESSION 6 Mario de Bono CHAIR MRC Laboratory of Molecular Biology, Cambridge, GB IFOM – Instituto FIRC di Oncologia Molecolare, Milan, IT 11:00 Rebecca Matsas Stem cells: a step closer to understanding and treating neurodegeneration 13:40 Roberto Solano The Jasmonate signaling pathway in plants Hellenic Pasteur Institute, Athens, GR Universidad Autónoma de Madrid, ES 11:20 Jean-Louis Bessereau Genetic deconstruction of the synapse 14:00 Randolf Menzel Memory consolidation during sleep in an insect, the honeybee Université Claude Bernard Lyon 1, FR Free University Berlin, DE 11:40 Pavel Tomancak Patterns of gene expression in development and evolution 14:20 Fiona Powrie Gut reactions: immune pathways in the intestine in health and disease Max Planck Institute of Molecular Cell Biology & Genetics, Dresden, DE University of Oxford, GB 12:00 Elena Cattaneo Neurons from stem cells for Huntington’s Disease research: combining 14:50 Andrew Carter Transporting cargo over long distances: insights from dynein/dynactin genetics with cell biology and evolution structures University of Milan, IT MRC Laboratory of Molecular Biology, Cambridge, GB 12:20 John Hardy The genomic basis of neurodegenerative disease 15:10 – 15:30 COFFEE BREAK EMBL OPERON FOYER University College London, GB

SESSION 3 Duncan Odom CHAIR University of Cambridge, GB 12:40 Rainer Friedrich Deconstruction and reconstruction of neuronal computations in the olfactory system 15:30 Kristina Djinovic-Carugo Toward the molecular structure of muscle Z-disk: by lego building blocks Friedrich Miescher Institute for Biomedical Research, Basel, CH University of Vienna, AT 13:00 Gilles Laurent Do dragons dream? 15:50 Roger Goody The structural and mechanistic basis for Rab action Max Planck Institute for Brain Research, Frankfurt, DE Max Planck Institute of Molecular Physiology, Dortmund, DE 13:20 – 14:00 LUNCH EMBL OPERON FOYER 16:10 Daniel Müller Molecular mechanics guiding cell shape changes in mitosis ETH Zurich, CH SESSION 7 Crisanto Gutierrez CHAIR Universidad Autónoma de Madrid, ES 16:30 Gulnara Yusupova Molecular basis for protein synthesis by the ribosome 14:00 Ian Tomlinson Before cancer evolution became fashionable ... Institute of Genetics and Molecular and Cellular Biology, Strasbourg, FR Wellcome Trust Centre for Human Genetics, Oxford, GB 16:50 Manajit Hayer-Hartl Chaperones for RuBisCO biogenesis and metabolic repair 14:20 Raffaella Santoro Long non-coding RNAs and the regulation of genome architecture Max Planck Institute of Biochemistry, Martinsried, DE University of Zurich, CH 17:10 Xiaodong Zhang Structures and mechanisms of macromolecular machines 14:40 Maria Mota The complexity and the simplicity of host-Plasmodium interactions Imperial College London, GB Universidade de Lisboa, PT 17:30 – 17:50 COFFEE BREAK EMBL OPERON FOYER 15:00 Agnieszka Chacinska Biogenesis of mitochondria International Institute of Molecular and Cell Biology, Warsaw, PL SESSION 4 Ian Chambers CHAIR University of Edinburgh, GB 15:20 Ana Caño-Delgado Brassinosteroid signaling in plant development 17:50 Hong Wu PTEN and cancer stem cells Centre de Recerca en Agrigenómica, Barcelona, ES Peking University, CN 15:40 Marcos Malumbres Cell cycle regulation and therapeutic opportunities in cancer 18:10 Frank Buchholz Genome editing and functional genomics in medicine Centro Nacional de Investigaciones Oncológicas, Madrid, ES TU Dresden, DE 16:00 – 16:20 COFFEE BREAK EMBL OPERON FOYER 18:30 Oscar Fernandez-Capetillo Exploring the roles of replicative stress in cancer and ageing Centro Nacional de Investigaciones Oncológicas, Madrid, ES SESSION 8 Deborah Bourc'his CHAIR Institut Curie, Paris, FR 18:50 Huck Hui Ng Systems biology of stem cells 16:20 Vishva Dixit Signaling lessons from Death Receptors: the inflammasome and beyond Genome Institute of Singapore, SG Genentech, Inc, South San Francisco, US 19:10 Hans Schöler Induction of pluripotency without Oct4 16:40 Alexander Stark Decoding transcriptional regulation in Drosophila Max Planck Institute for Molecular Biomedicine, Münster, DE Research Institute of Molecular Pathology, Vienna, AT 19:30 Douglas Winton Insights into intestinal self renewal from clonal dynamics 17:00 Antoine Peters Chromatin dynamics and epigenetic inheritance in mammalian University of Cambridge, GB reproduction 19:50 Buses to Palais Prinz Carl Friedrich Miescher Institute for Biomedical Research, Basel, CH 20:10 APÉRITIF PALAIS PRINZ CARL 17:20 Claire Rougeulle Long noncoding RNAs and X chromosome inactivation in mammals 20:30 GALA DINNER PALAIS PRINZ CARL Université Paris Diderot, FR 17:40 – 18:00 COFFEE BREAK EMBL OPERON FOYER 23:00 Buses to hotels 18:00 EMBO Members' Forum EMBL OPERON FOYER 19:40 Welcome Reception EMBO BUILDING 20:30 DINNER EMBL CANTEEN 22:15 Buses to hotels

EMBO Members Meeting 2016 | Programme www.embo.org EMBO Members Meeting 2016 | Programme www.embo.org Friday 28 OCTOBER 08:25 Bus from Villa Toskana Hotel 08:30 Bus from ISG Hotel 08:30 – 09:00 COFFEE BREAK EMBL OPERON FOYER

SESSION 9 Detlef Weigel CHAIR Max Planck Institute for Developmental Biology, Tübingen, DE

09:00 Didier Stainier Genetic compensation induced by deleterious mutations but not gene knockdowns Max Planck Institute for Heart and Lung Research, Bad Nauheim, DE 09:20 Jernej Ule Understanding the assembly of regulatory protein-RNA complexes University College London, GB 09:40 Dana Branzei Mechanisms and regulators of DNA replication and chromosome structure integrity IFOM – Instituto FIRC di Oncologia Molecolare, Milan, IT 10:00 Antonella Viola Signaling compartmentalization in immunity University of Padova, IT 10:20 Jan Lohmann Plant stem cell regulation: mobile transcription factors and the environment University of Heidelberg, DE 10:40 – 11:00 COFFEE BREAK EMBL OPERON FOYER

SESSION 10 Felix Wieland CHAIR University of Heidelberg, DE

11:00 Fatima Mechta-Grigoriou Investigating some pathophysiological consequences of chronic oxidative stress Institut Curie, Paris, FR 11:20 Detlev Arendt Evolution of the nervous system: a cell type perspective EMBL, Heidelberg, DE 11:40 István Katona Cell-type-specific nanoscale molecular imaging by VividSTORM Institute of Experimental Medicine, Budapest, HU 12:00 Danièle Werck-Reichhart Evolving fast and slow: cytochromes P450 shape plant metabolism Institute of Plant Molecular Biology, Strasbourg, FR 12:20 Vincent Savolainen Ecological genomics of the evolution of species on islands Imperial College London, UK 12:40 Jukka Jernvall Nature read in tooth University of Helsinki, FI 13:00 – 14:00 LUNCH EMBL CANTEEN

SESSION 11 Jonathan Howard CHAIR Instituto Gulbenkian de Ciência, Oeiras, PT

14:00 Andreas Wagner Robustness and innovation in the simplest molecular systems University of Zurich, CH 14:20 Magnus Nordborg The population genetics of Arabidopsis Gregor Mendel Institute of Molecular Plant Biology, Vienna, AT 14:40 Ove Nilsson Molecular regulation of tree phenology Umeå Plant Science Centre, SE 15:00 Virginijus Siksnys From CRISPR-Cas mechanism towards genome editing Vilnius University, LT 15:20 Hans-Reimer Rodewald Endogeneous barcoding: a new approach for high resolution in vivo lineage tracing DKFZ, Heidelberg, DE 15:40 John Briggs Coated vesicles and enveloped viruses – new views from cryo-EM EMBL, Heidelberg, DE 16:00 Jane Parker Networking in plant immunity Max Planck Institute for Plant Breeding Research, Cologne, DE 26 – 28 OCTOBER 2016 16:20 Maria Leptin Closing Address 16:30 FAREWELL DRINKS EMBL OPERON FOYER EMBO Members Meeting 2016 Programme

www.embo.org EMBO Members Meeting 2016 | Programme www.embo.org