Issue 81 of the Genetics Society Newsletter
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ZMYND10 Functions in a Chaperone Relay During Axonemal Dynein Assembly
bioRxiv preprint doi: https://doi.org/10.1101/233718; this version posted December 13, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 ZMYND10 functions in a chaperone relay during axonemal dynein assembly. 2 3 Girish R Mali1,9 , Patricia Yeyati1, Seiya Mizuno2, Margaret A Keighren1, Petra zur Lage3, Amaya 4 Garcia-Munoz4, Atsuko Shimada5, Hiroyuki Takeda5, Frank Edlich6, Satoru Takahashi2,7, Alex von 5 Kreigsheim4,8, Andrew Jarman3 and Pleasantine Mill1,*. 6 7 1. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of 8 Edinburgh, Edinburgh, UK, EH4 2XU 9 2. Laboratory Animal Resource Centre, University of Tsukuba, Tsukuba, Japan, 305-8575 10 3. Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK, EH8 9XD 11 4. Systems Biology Ireland, University College Dublin, Dublin, Ireland 12 5. Department of Biological Sciences, University of Tokyo, Tokyo, Japan, 113-0033 13 6. Institute for Biochemistry and Molecular Biology, University of Freiburg, Freiburg, Germany, 14 79104 15 7. Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, 16 Japan, 305-8575 17 8. Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University 18 of Edinburgh, Edinburgh, UK, EH4 2XU 19 9. Current address: MRC Laboratory of Molecular Biology, Cambridge, UK, CB2 0QH 20 * Corresponding author: [email protected] 21 22 23 24 25 26 27 28 29 30 31 1 bioRxiv preprint doi: https://doi.org/10.1101/233718; this version posted December 13, 2017. -
Ventral Hindgut and Bladder Development
Ventral Hindgut and Bladder Development by Wei CHENG A thesis submitted in conformity with the requirements For the degree of PhD Graduate Department of Institute of Medical Science University of Toronto © Copyright by Wei Cheng, 2008 Library and Bibliotheque et 1*1 Archives Canada Archives Canada Published Heritage Direction du Branch Patrimoine de I'edition 395 Wellington Street 395, rue Wellington Ottawa ON K1A0N4 Ottawa ON K1A0N4 Canada Canada Your file Votre reference ISBN: 978-0-494-40009-8 Our file Notre reference ISBN: 978-0-494-40009-8 NOTICE: AVIS: The author has granted a non L'auteur a accorde une licence non exclusive exclusive license allowing Library permettant a la Bibliotheque et Archives and Archives Canada to reproduce, Canada de reproduire, publier, archiver, publish, archive, preserve, conserve, sauvegarder, conserver, transmettre au public communicate to the public by par telecommunication ou par Plntemet, prefer, telecommunication or on the Internet, distribuer et vendre des theses partout dans loan, distribute and sell theses le monde, a des fins commerciales ou autres, worldwide, for commercial or non sur support microforme, papier, electronique commercial purposes, in microform, et/ou autres formats. paper, electronic and/or any other formats. The author retains copyright L'auteur conserve la propriete du droit d'auteur ownership and moral rights in et des droits moraux qui protege cette these. this thesis. Neither the thesis Ni la these ni des extraits substantiels de nor substantial extracts from it celle-ci ne doivent etre imprimes ou autrement may be printed or otherwise reproduits sans son autorisation. reproduced without the author's permission. -
Gabriel Dover)
Dear Mr Darwin (Gabriel Dover) Home | Intro | About | Feedback | Prev | Next | Search Steele: Lamarck's Was Signature Darwin Wrong? Molecular Drive: the Third Force in evolution Geneticist Gabriel Dover claims that there is a third force in evolution: 'Molecular Drive' beside natural selection and neutral drift. Molecular drive is operationally distinct from natural selection and neutral drift. According to Dover it explains biological phenomena, such as the 700 copies of a ribosomal RNA gene and the origin of the 173 legs of the centipede, which natural selection and neutral drift alone cannot explain. by Gert Korthof version 1.3 24 Mar 2001 Were Darwin and Mendel both wrong? Molecular Drive is, according to Dover, an important factor in evolution, because it shapes the genomes and forms of organisms. Therefore Neo-Darwinism is incomplete without Molecular Drive. It is no wonder that the spread of novel genes was ascribed to natural selection, because it was the only known process that could promote the spread of novel genes. Dover doesn't reject the existence of natural selection but points out cases where natural selection clearly fails as a mechanism. Molecular drive is a non-Darwinian mechanism because it is independent of selection. We certainly need forces in evolution, since natural selection itself is not a force. It is the passive outcome of other processes. It is not an active process, notwithstanding its name. Natural selection as an explanation is too powerful for its own good. Molecular drive is non-Mendelian because some DNA segments are multiplied disproportional. In Mendelian genetics genes are present in just two copies (one on the maternal and one on the paternal chromosome). -
Download Program Guide
2011 C. elegans Meeting Organizing Committee Co-chairs: Oliver Hobert Columbia University Meera Sundaram University of Pennsylvania Organizing Committee: Raffi Aroian University of California, San Diego Ikue Mori Nagoya University Jean-Louis Bessereau INSERM Benjamin Podbilewicz Technion Israel Institute of Keith Blackwell Harvard Medical School Technology Andrew Chisholm University of California, San Diego Valerie Reinke Yale University Barbara Conradt Dartmouth Medical School Janet Richmond University of Illinois, Chicago Marie Anne Felix CNRS-Institut Jacques Monod Ann Rougvie University of Minnesota David Greenstein University of Minnesota Shai Shaham Rockefeller University Alla Grishok Columbia University Ahna Skop University of Wisconsin, Madison Craig Hunter Harvard University Ralf Sommer Max-Planck Institute for Bill Kelly Emory University Developmental Biology, Tuebingen Ed Kipreos University of Georgia Asako Sugimoto RIKEN, Kobe Todd Lamitina University of Pennsylvania Heidi Tissenbaum University of Massachusetts Chris Li City College of New York Medical School Sponsored by The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 telephone: (301) 634-7300 fax: (301) 634-7079 e-mail: [email protected] Web site: http:/www.genetics-gsa.org Front cover design courtesy of Ahna Skop 1 Table of Contents Schedule of All Events.....................................................................................................................4 Maps University of California, Los Angeles, Campus .....................................................................7 -
Completed Thesis
THE UNIVERSITY OF WINCHESTER Faculty of Humanities and Social Sciences Human Uniqueness: Twenty-First Century Perspectives from Theology, Science and Archaeology Josephine Kiddle Bsc (Biology) MA (Religion) Thesis for the degree of Doctor of Philosophy February 2013 This Thesis has been completed as a requirement for a postgraduate research degree of the University of Winchester. The word count is: 89350 THE UNIVERSITY OF WINCHESTER ABSTRACT FOR THESIS Human Uniqueness: Twenty-First Century Perspectives from Theology, Science and Archaeology A project aiming to establish, through the three disciplines, the value of human uniqueness as an integrating factor for science with theology Josephine Kiddle Bsc (Biology) MA (Religion) Faculty of Humanities and Social Sciences Doctor of Philosophy February 2013 The theme that underlies the thesis is the challenge presented by science, as it developed from the time of the Enlightenment through the centuries until the present day, to Christian theology. The consequent conflict of ideas is traced in respect of biological science and the traditions of Protestant Christian doctrine, together with the advances of the developing discipline of prehistoric archaeology since the early nineteenth century. The common ground from which disagreement stemmed was the existence of human beings and the uniqueness of the human species as a group amongst all other creatures. With the conflict arising from this challenge, centring on the origin and history of human uniqueness, a rift became established between the disciplines which widened as they progressed through to the twentieth century. It is this separation that the thesis takes up and endeavours to analyse in the light of the influence of advancing science on the blending of philosophical scientific ideas with the elements of Christian faith of former centuries. -
Caenorhabditis Microbiota: Worm Guts Get Populated Laura C
Clark and Hodgkin BMC Biology (2016) 14:37 DOI 10.1186/s12915-016-0260-7 COMMENTARY Open Access Caenorhabditis microbiota: worm guts get populated Laura C. Clark and Jonathan Hodgkin* Please see related Research article: The native microbiome of the nematode Caenorhabditis elegans: Gateway to a new host-microbiome model, http://dx.doi.org/10.1186/s12915-016-0258-1 effects on the life history of the worm are often profound Abstract [2]. It has been increasingly recognized that the worm Until recently, almost nothing has been known about microbiota is an important consideration in achieving a the natural microbiota of the model nematode naturalistic experimental model in which to study, for Caenorhabditis elegans. Reporting their research in instance, host–pathogen interactions or worm behavior. BMC Biology, Dirksen and colleagues describe the first Dirksen et al [3] present the first step towards under- sequencing effort to characterize the gut microbiota standing understanding the complex interactions of the of environmentally isolated C. elegans and the related natural worm microbiota by reporting a 16S rDNA-based taxa Caenorhabditis briggsae and Caenorhabditis “head count” of the bacterial population present in wild remanei In contrast to the monoxenic, microbiota-free nematode isolates (Fig. 1). Interestingly, it appears that cultures that are studied in hundreds of laboratories, it nematodes isolated from diverse natural environment- appears that natural populations of Caenorhabditis s—and even those that have been maintained for a short harbor distinct microbiotas. time on E. coli following isolation—share a “core” host- defined microbiota. This finding is in agreement with work by Berg et al. -
Translational Activity of the Splicing Factor SRSF1 Is Required for Development and Cilia Function
bioRxiv preprint doi: https://doi.org/10.1101/2020.09.04.263251; this version posted September 4, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Haward, Maslon, Yeyati et al. Translational activity of the splicing factor SRSF1 is required for development and cilia function Fiona Haward,1,5,6 Magdalena M. Maslon,1,6 Patricia L. Yeyati,1,6 Nicolas Bellora,2 Jan N. Hansen,3 Stuart Aitken,1 Jennifer Lawson,1 Alex von Kriegsheim,4 Dagmar Wachten,3 Pleasantine Mill,1,* Ian R. Adams1,* and Javier F. Cáceres1,7,* 1MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK 2IPATEC, ConseJo Nacional de Investigaciones, Científicas y Técnicas (CONICET)- Universidad Nacional del Comahue, 8400, Bariloche, Argentina. 3Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany 4Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK 5Present address: Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK 6These authors contributed equally to this work 7Lead contact *Correspondence: [email protected]; [email protected]; [email protected] Running title: Nucleo-cytoplasmic shuttling of SR proteins [Key Words: SR proteins; SRSF1; alternative splicing; mRNA translation; cilia] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.04.263251; this version posted September 4, 2020. -
From the President's Desk
JAN/FEB 2006 From the President’s desk: 2006, the 75th anniversary of the Genetics Society of America, will be marked by a number of initiatives to reinvigorate the Society’s mission of promoting research and education in genetics. A highlight was the recently held GSA sponsored conference, “Genetic Analysis: From Model Organisms to Human Biology” in San Diego from January 5-7. This conference emphasized the importance of model organism research by illustrating the crucial contributions to human biology resulting from discoveries in these organisms. The National Institutes of Health (NIH) supported this conference both financially and by participation of key NIH administrators, including Jeremy M. Berg, director of the National Institute of General Medical Sciences. In addition to the superb science talks by international leaders the MOHB conference showcased other important and new GSA initiatives including education, public policy advocacy, graduate student support and recognition of outstanding model organism geneticists. Robin Wright, Education Committee chair, led a round table discussion on undergraduate education and the Joint Steering Committee for Public Policy and the Congressional Liaison Committee sponsored a session on science advocacy and public policy. There was a mentor lunch to support graduate students and postdocs in the next steps of their careers, and the three GSA medals were presented during the banquet, with Victor Ambros receiving the GSA Medal, Fred Sherman the Beadle Award, and Masatoshi Nei the Morgan Award. (For research highlights at the meeting, see pages 6 and 7 of this issue.) The 75th anniversary will also usher in changes to our society’s journal, GENETICS. -
Mating Patterns in a Hybrid Zone of Fire-Bellied Toads
Heredity (2005) 94, 247–257 & 2005 Nature Publishing Group All rights reserved 0018-067X/05 $30.00 www.nature.com/hdy Mating patterns in a hybrid zone of fire-bellied toads (Bombina): inferences from adult and full-sib genotypes BNu¨ rnberger1, NH Barton2, LEB Kruuk2 and TH Vines1,2,3 1Department Biologie II, Ludwig-Maximilians-Universita¨tMu¨nchen, Grosshaderner Str. 2, 82152 Planegg-Martinsried, Germany; 2Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland We present two novel methods to infer mating patterns from The second approach is based solely on the offspring genetic data. They differ from existing statistical methods of genotypes and relies on the fact that a linear relation exists parentage inference in that they apply to populations that between associations among the offspring and those in the deviate from Hardy–Weinberg and linkage equilibrium, and population of breeding pairs. We apply both methods to a so are suited for the study of assortative mating in hybrid sample from the hybrid zone between the fire-bellied toads zones. The core data set consists of genotypes at several Bombina bombina and B. variegata (Anura: Disco glossidae) loci for a number of full-sib clutches of unknown parentage. in Croatia. Consistently, both approaches provide no Our inference is based throughout on estimates of allelic evidence for a departure from random mating, despite associations within and across loci, such as heterozygote adequate statistical power. Instead, B. variegata-like indivi- deficit and pairwise linkage disequilibrium. In the first duals among the adults contributed disproportionately to the method, the most likely parents of a given clutch are offspring cohort, consistent with their preference for the type determined from the genotypic distribution of the associated of breeding habitat in which this study was conducted. -
Genetics Society News
July 2008 . ISSUE 59 GENETICS SOCIETY NEWS www.genetics.org.uk IN THIS ISSUE Genetics Society News is edited by Steve Russell. Items for future issues should be sent to Steve Russell, preferably by email to • Genetics Society Epigenetics Meeting [email protected], or hard copy to Department of Genetics, • Genetics Society Sponsored Meetings University of Cambridge, Downing Street, Cambridge CB2 3EH. The Newsletter is published twice a year, with copy dates of 1st June and • Travel, Fieldwork and Studentship Reports 26th November. • John Evans: an Appreciation Cocoons of the parasitoid wasp Cotesia vestalis on cabbage leaf in Taiwan. From the • Twelve Galton Lectures fieldwork report by Jetske G. de Boer on page 36. • My Favourite Paper A WORD FROM THE EDITOR A word from the editor ow soon until the $1000 based on the results of tests we genome is actually with barely understand! Here in the Hus and individual UK there is currently a sequencing is widespread? The moratorium, adhered to by publication of increasing most insurers, on the use of numbers of individual human genetic testing information for genome sequences suggests assessing life insurance that we should start to consider applications. It is important some of the implications that this remains in place and associated with the availability its effectiveness is reviewed of personal genetic well before the current information. In this issue we moratorium expires in 2011. present two articles reflecting The Human Genetics on his issue: a report from a Commission Genetics Society sponsored (http://www.hgc.gov.uk) meeting recently held in monitor issues relating to Cambridge organised by The genetic discrimination in the Triple Helix, an international UK and are a point of contact undergraduate organisation, as for those with any concerns in the Millennium Technology Prize. -
3718 Issue63july2010 1.Pdf
Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 1 JULYJULLYY 2010 | ISSUEISSUE 63 GENETICSGENNETICSS SOCIETYSOCIEETY NENEWSEWS In this issue The Genetics Society NewsNewws is edited by U Genetics Society PresidentPresident Honoured Honoured ProfProf David Hosken and items ittems for future future issues can be sent to thee editor,editor, preferably preferably U Mouse Genetics Meeting by email to [email protected],D.J.Hosken@@exeter.ac.uk, or U SponsoredSponsored Meetings Meetings hardhard copy to Chair in Evolutionary Evoolutionary Biology, Biology, UniversityUniversity of Exeter,Exeter, Cornwall Cornnwall Campus, U The JBS Haldane LectureLecture Tremough,Tremough, Penryn, TR10 0 9EZ UK.UK. The U Schools Evolutionn ConferenceConference Newsletter is published twicet a year,year, with copy dates of 1st June andand 26th November.November. U TaxiTaxi Drivers The British YeastYeaste Group Group descend on Oxford Oxford for their 2010 meeting: m see the reportreport on page 35. 3 Image © Georgina McLoughlin Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 2 A WORD FROM THE EDITOR A word from the editor Welcome to issue 63. In this issue we announce a UK is recognised with the award of a CBE in the new Genetics Society Prize to Queen’s Birthday Honours, tells us about one of Welcome to my last issue as join the medals and lectures we her favourite papers by Susan Lindquist, the 2010 editor of the Genetics Society award. The JBS Haldane Mendel Lecturer. Somewhat unusually we have a News, after 3 years in the hot Lecture will be awarded couple of Taxi Drivers in this issue – Brian and seat and a total of 8 years on annually to recognise Deborah Charlesworth are not so happy about the committee it is time to excellence in communicating the way that the print media deals with some move on before I really outstay aspects of genetics research to scientific issues and Chris Ponting bemoans the my welcome! It has been a the public. -
DNA Evidence: Probability, Population Genetics, and the Courts David H
Penn State Law eLibrary Journal Articles Faculty Works 1993 DNA Evidence: Probability, Population Genetics, and the Courts David H. Kaye Penn State Law Follow this and additional works at: http://elibrary.law.psu.edu/fac_works Part of the Criminal Law Commons, Evidence Commons, and the Science and Technology Law Commons Recommended Citation David H. Kaye, DNA Evidence: Probability, Population Genetics, and the Courts, 7 Harv. J.L. & Tech. 101 (1993). This Article is brought to you for free and open access by the Faculty Works at Penn State Law eLibrary. It has been accepted for inclusion in Journal Articles by an authorized administrator of Penn State Law eLibrary. For more information, please contact [email protected]. Volume 7, Fall Issue, 1993 DNA EVIDENCE: PROBABILITY, POPULATION GENETICS, AND THE COURTS David H. Kaye* INTRODUCTION Courts, attorneys, scientists, statisticians, journalists, and government 4 agencies have been explaining,' examining, 2 promoting,3 proselytizing, denigrating,5 and otherwise struggling with DNA identification evidence at least since 1985.6 In the first wave of cases, expert testimony for the * Regents' Professor, Arizona State University College of Law, Box 877906, Tempe, AZ 85287-7906 (602 965-2922, [email protected]). A version of this paper was presented at the 1992 Joint Statistical Meetings of the American Statistical Association, the Biometric Society, and the Institute of Mathematical Statistics. I am grateful to Herman Cheroff for comments on that paper and to Colin Aitken, Richard Lempert, Bruce Weir, and especially Bernard Devlin for comments on later drafts. The errors that remain despite this guidance are entirely my own.