POSTER PRESENTATIONS POSTER SESSION 1 – Monday 15Th
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Olfactory Sulcus Morphology in Teenagers with First-Presentation
Psychiatry Research: Neuroimaging 292 (2019) 1–4 Contents lists available at ScienceDirect Psychiatry Research: Neuroimaging journal homepage: www.elsevier.com/locate/psychresns Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder T ⁎ Tsutomu Takahashia, , Yumiko Nishikawaa, Dennis Velakoulisb, Michio Suzukia, Patrick D. McGorryc,d, Christos Pantelisb, Andrew M. Chanenc,d a Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, Japan b Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia c Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia d Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia ARTICLE INFO ABSTRACT Keywords: Gray matter reduction of the orbitofrontal cortex (OFC) has been reported in borderline personality disorder Neurodevelopment (BPD), but it remains unknown whether the BPD patients exhibit morphologic changes of the olfactory sulcus, a Orbitofrontal cortex potential marker of forebrain development located on the OFC. We used magnetic resonance imaging to in- Trauma vestigate the length and depth of the olfactory sulcus in 20 teenagers (15 females and 5 males) with first- Impulsivity presentation BPD and 20 healthy controls (15 females and 5 males). While there was no group difference in the Magnetic resonance imaging length of the sulcus, the BPD patients (especially those with a history of trauma) had a significantly shallower right olfactory sulcus compared with controls. In addition, sulcus depth was negatively correlated with the severity of impulsivity and affective instability in the BPD patients. These preliminary findings may suggest a significant role of environmental risk factors (i.e., trauma exposure) during childhood to adolescence in the neurobiology of BPD. -
Trafficking and Signaling of Parkin-Associated
Distribution Agreement In presenting this thesis or dissertation as a partial fulfillment of the requirements for an advanced degree from Emory University, I hereby grant to Emory University and its agents the non-exclusive license to archive, make accessible, and display my thesis or dissertation in whole or in part in all forms of media, now or hereafter known, including display on the world wide web. I understand that I may select some access restrictions as part of the online submission of this thesis or dissertation. I retain all ownership rights to the copyright of the thesis or dissertation. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation. Signature: _____________________________ ______________ Jill Harley Dunham Date Trafficking and Signaling of Parkin-Associated Endothelin-Like Receptor GPR37 By Jill Harley Dunham B.S. The University of Georgia, 2003 Graduate Division of Biological and Biomedical Sciences Program in Molecular and Systems Pharmacology ________________________________ Randy Hall, Ph.D. Adviser _____________________________ Allan Levey, M.D., Ph.D. Committee Member _____________________________ John Hepler, Ph.D. Committee Member _____________________________ Lian Li, Ph.D. Committee Member Accepted: ________________________________ Lisa A. Tedesco, Ph.D. Dean of the Graduate School ________________________________ Date TRAFFICKING AND SIGNALING OF THE PARKIN-ASSOCIATED ENDOTHELIN-LIKE RECEPTOR GPR37 By Jill Harley Dunham B.S., University of Georgia, -
Ficha Catalográfica
Naiani Ferreira Marques Guanosina previne alterações mitocondriais, o efeito tipo- depressivo e o déficit olfatório induzido por modelos experimentais da doença de Parkinson Tese submetida ao Programa de Pós-graduação em Bioquímica do Centro de Ciências Biológicas da Universidade Federal de Santa Catarina como requisito parcial à obtenção do grau de doutora em Bioquímica. Orientadora: Profa. Dra. Carla Inês Tasca Florianópolis - SC 2019 Ficha de identificação da obra elaborada pelo autor, através do Programa de Geração Automática da Biblioteca Universitária da UFSC. Marques, Naiani Ferreira Guanosina previne alterações mitocondriais, o efeito tipo-depressivo e o déficit olfatório induzido por modelos experimentais da doença de Parkinson / Naiani Ferreira Marques ; orientadora, Carla Inês Tasca, 2019. 216 p. Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2019. Inclui referências. 1. Bioquímica. 2. Doença de Parkinson. 3. Guanosina. 4. 6-OHDA. 5. MPTP. I. Tasca, Carla Inês. II. Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Bioquímica. III. Título. Dedico esse trabalho aos meus pais Jairo e Cleusa que sempre trabalharam muito para garantir a minha educação e sempre foram meus maiores apoiadores. AGRADECIMENTOS Agradeço primeiramente aos meus pais Jairo e Cleusa por toda a base, pelos ensinamentos e pelo apoio incondicional em todas as fases da minha educação e da minha vida. A sabedoria de vocês sempre será meu exemplo em todos os aspectos. Agradeço muito a minha orientadora Profa Dra Carla Tasca pela experiência, pelo conhecimento, pelo seu tempo dedicado ao meu trabalho, pela paciência e por todas as oportunidades que estar em seu laboratório me proporcionaram. -
MATTERS and Sound
Letters to the Editor 833 1 Kennedy WR, Alter M, Sung JH. Progressive seemed in the first days to originate exter- The inhibition was revealed in our studies proximal spinal and bulbar muscular atro- phy of late onset: a sex-linked recessive trait. nally and was heard bilaterally. The melody during a period of voluntary contraction by J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.56.7.833 on 1 July 1993. Downloaded from Neurology 1968;18:671-80. she heard was extremely loud, leading her stimulating the motor cortex at a strength 2 Harding AE, Thomas PK, Baraister M, to ask surrounding people to turn off the lower than that required to produce excita- Bradbury PG, Morgan-Hughes JA, radio, which she believed to be the source tion under the same conditions. A recent Ponsford JR. X-linked recessive bulbospinal neuronopathy: a report of ten cases. J Neurol of the tune. The music began suddenly, was study has reported that the discharge of Neurosurg Psychiatty 1982;45: 1012-19. slow, clear and reminiscent of popular motor neurons in the first dorsal interosseus 3 Mukai E, Mitsuma T, Takahashi A, Sobue I. songs that she had heard in her youth, but muscle of the hand of a patient with multi- Endocrinological study of hypogonadism and feminization in patients with bulbar were still unknown to her. She was able to ple sclerosis could be suppressed by tran- spinal muscular atrophy. Clin Neurol sing this melody. Shortly after the onset of scranial magnetic stimulation of the motor (Tokyo) 1984;24:925-9. -
Contribution of Enterococcus Faecalis to Urinary Tract Infection
Western University Scholarship@Western Electronic Thesis and Dissertation Repository 3-29-2018 3:00 PM Contribution of Enterococcus faecalis to urinary tract infection Samantha Ann Whiteside The University of Western Ontario Supervisor Reid, Gregor The University of Western Ontario Co-Supervisor Burton, Jeremy P. The University of Western Ontario Graduate Program in Microbiology and Immunology A thesis submitted in partial fulfillment of the equirr ements for the degree in Doctor of Philosophy © Samantha Ann Whiteside 2018 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Bacterial Infections and Mycoses Commons Recommended Citation Whiteside, Samantha Ann, "Contribution of Enterococcus faecalis to urinary tract infection" (2018). Electronic Thesis and Dissertation Repository. 5270. https://ir.lib.uwo.ca/etd/5270 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. Abstract The purpose of this thesis was to increase understanding of enterococcal urinary tract infection (UTI), in particular, the response of Enterococcus to antibiotic prophylaxis in vitro and in vivo and enterococcal communication with the bladder. We studied the in vitro effects of trimethoprim-sulfamethoxazole (TMP/SMX) and nitrofurantoin, two of the most commonly used antibiotic treatments for the management of both UTI and recurrent UTI (RUTI), on Enterococcus faecalis attachment to urothelial cells. In doing so, we documented increases in bacterial attachment at growth inhibitory concentrations of nitrofurantoin, but not TMP/SMX. This increased virulence did not correlate with increased expression of virulence factors but was correlated with increased expression of three putative genes. -
The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation During Adulthood and Critical Stages of Development
brain sciences The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development Edited by Angela Roberts Printed Edition of the Special Issue Published in Brain Sciences www.mdpi.com/journal/brainsci The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development Special Issue Editor Angela Roberts MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editor Angela Roberts University of Cambridge UK Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Actuators (ISSN 2076-0825) from 2018 to 2019 (available at: https://www.mdpi.com/journal/brainsci/special issues/Neuro Emotion). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03921-702-1 (Pbk) ISBN 978-3-03921-703-8 (PDF) c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. -
On the Scent of Human Olfactory Orbitofrontal Cortex: Meta-Analysis and Comparison to Non-Human Primates
Brain Research Reviews 50 (2005) 287 – 304 www.elsevier.com/locate/brainresrev Review On the scent of human olfactory orbitofrontal cortex: Meta-analysis and comparison to non-human primates Jay A. Gottfrieda,*, David H. Zaldb aDepartment of Neurology and the Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Searle 11-453, Chicago, IL 60611, USA bDepartment of Psychology, Vanderbilt University, Nashville, TN 37240, USA Accepted 25 August 2005 Available online 6 October 2005 Abstract It is widely accepted that the orbitofrontal cortex (OFC) represents the main neocortical target of primary olfactory cortex. In non-human primates, the olfactory neocortex is situated along the basal surface of the caudal frontal lobes, encompassing agranular and dysgranular OFC medially and agranular insula laterally, where this latter structure wraps onto the posterior orbital surface. Direct afferent inputs arrive from most primary olfactory areas, including piriform cortex, amygdala, and entorhinal cortex, in the absence of an obligatory thalamic relay. While such findings are almost exclusively derived from animal data, recent cytoarchitectonic studies indicate a close anatomical correspondence between non-human primate and human OFC. Given this cross-species conservation of structure, it has generally been presumed that the olfactory projection area in human OFC occupies the same posterior portions of OFC as seen in non-human primates. This review questions this assumption by providing a critical survey of the localization of primate and human olfactory neocortex. Based on a meta-analysis of human functional neuroimaging studies, the region of human OFC showing the greatest olfactory responsivity appears substantially rostral and in a different cytoarchitectural area than the orbital olfactory regions as defined in the monkey. -
Achems XLII April 19 – 23, 2021 Virtual Meeting Program & Abstracts
AChemS XLII April 19 – 23, 2021 Virtual Meeting Program & Abstracts Monday, April 19, 2021 Monday, April 19, 2021 10:00 - 12:00 PM Welcome & Keynote Lecture Chair(s): Max Fletcher Welcome by AChemS 2021 President. Linda Barlow University of Colorado Anschutz Medical Campus Program Highlights. Max Fletcher The University of Tennessee Health Science Center Awards Ceremony. Nirupa Chaudhari University of Miami KEYNOTE: Mouse Facial Expressions Reflect Emotions and Reveal Subjective Value. Nadine Gogolla Max Planck Institute of Neurobiology Questions & Answers Monday, April 19, 2021 12:00 - 1:00 PM Graduate Students and Postdoc Member Meet & Greet (Graduate Students and Postdocs Only) Chair(s): Jess Kanwal, Kellie Hyde, Kara Fulton Monday, April 19, 2021 1:00 - 3:00 PM Cell Types in Taste Buds and Tentacles 1 Chair(s): Thomas Finger, Sue Kinnamon Cell Types in Taste Buds and Tentacles. Thomas Finger Rocky Mtn. Taste & Smell Ctr. / U. Colo Med Sch This symposium will discuss the current thinking about the diversity of cells within taste buds and chemotactile sensory organs of octopus suckers. While octopus suckers may seem an odd juxtaposition, both taste buds and sucker chemosensory receptor cells share the property of being contact chemosensory organs responsive to sapid chemical cues crucial for eliciting feeding. Both sucker chemotactile sensory organs and taste buds possess different morphological types of receptor cells that correlate with different functional properties. Vertebrate taste buds are classically described as possessing 3 types of elongate taste cells yet recent studies suggest additional cell types exist and raise the question of how to define cell types in any chemoreceptor system. -
Purinergic Signaling in Cochlear Supporting Cells Reduces Hair
RESEARCH ARTICLE Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space Travis A Babola1, Calvin J Kersbergen1, Han Chin Wang1†, Dwight E Bergles1,2,3* 1The Solomon Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, United States; 2Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, United States; 3Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, United States Abstract Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement. In the auditory system, intrinsically generated activity arises within the cochlea, but the molecular mechanisms that initiate this activity remain poorly understood. We show that burst firing of mouse inner hair cells prior to hearing onset requires P2RY1 autoreceptors expressed by inner supporting cells. P2RY1 activation triggers K+ efflux and depolarization of hair cells, as well as osmotic shrinkage of supporting cells that dramatically increased the extracellular space and speed of K+ redistribution. Pharmacological inhibition or genetic disruption of P2RY1 suppressed neuronal burst firing by reducing K+ release, but unexpectedly enhanced their tonic firing, as water resorption by supporting cells reduced the extracellular space, leading to K+ accumulation. These studies indicate that purinergic signaling in *For correspondence: supporting cells regulates hair cell -
Musical Hallucinations in Schizophrenia
Mental Illness 2015; volume 7:6065 Musical hallucinations in reported having musical hallucinations.4 Notably the musical hallucinations tended to Correspondence: Robert G. Bota, UC Irvine schizophrenia be sudden in onset, familiar, and mixed instru- Health Neuropsychiatric Center, 101 The City mental and vocal, with most patients having a Drive South, Orange, CA 92868, USA. Jessica Galant-Swafford, Robert Bota soothing affective response to the music Tel.:+1.714.456.2056. Department of Psychiatry, University of (62%). Interestingly, when the musical halluci- E-mail: [email protected] California, Irvine, CA, USA nations had more religious content, the patients claimed to have less volitional control Received for publication: 8 June 2015. Accepted for publication: 8 June 2015. Musical hallucinations (MH) are complex over them. This suggests that the presence or phenomena that are associated with hearing absence of religious content in the musical This work is licensed under a Creative Commons loss, brain disease (glioma, epilepsy, cere- hallucination may be useful for differentiating Attribution NonCommercial 3.0 License (CC BY- brovascular disease, encephalitis), and psychi- between musical imagery and musical halluci- NC 3.0). atric disorders such as major depressive disor- nations. ©Copyright J. Galant-Swafford and R. Bota, 2015 der, bipolar disease, and schizophrenia. MH Baba and Hamada suggest that musical hal- lucinations in patients with schizophrenia are Licensee PAGEPress, Italy are also commonly seen in people without Mental Illness 2015; 7:6065 phenomena that originate as memory repre- otorhinolaryngological, neurological, or mental doi:10.4081/mi.2015.6065 illness pathology.1 sentations or pseudo-hallucinations akin to In his novel Musicophilia, Oliver Sacks evoked musical imagery, which transition into true hallucinations during the progression of writes that his patients with musical halluci- cal content that were obsessive-compulsive in the disease. -
Musical Hallucinations, Musical Imagery, and Earworms: a New Phenomenological Survey
Consciousness and Cognition 65 (2018) 83–94 Contents lists available at ScienceDirect Consciousness and Cognition journal homepage: www.elsevier.com/locate/concog Musical hallucinations, musical imagery, and earworms: A new phenomenological survey T ⁎ Peter Moseleya,b, , Ben Alderson-Daya, Sukhbinder Kumarc, Charles Fernyhougha a Psychology Department, Durham University, South Road, Durham DH1 3LE, United Kingdom b School of Psychology, University of Central Lancashire, Marsh Lane, Preston PR1 2HE, United Kingdom c Institute of Neuroscience, Newcastle University, Newcastle NE1 7RU, United Kingdom ARTICLE INFO ABSTRACT Keywords: Musical hallucinations (MH) account for a significant proportion of auditory hallucinations, but Auditory hallucinations there is a relative lack of research into their phenomenology. In contrast, much research has Musical hallucinations focused on other forms of internally generated musical experience, such as earworms (in- Earworms voluntary and repetitive inner music), showing that they can vary in perceived control, repeti- Mental imagery tiveness, and in their effect on mood. We conducted a large online survey (N = 270), including Phenomenology 44 participants with MH, asking participants to rate imagery, earworms, or MH on several variables. MH were reported as occurring less frequently, with less controllability, less lyrical content, and lower familiarity, than other forms of inner music. MH were also less likely to be reported by participants with higher levels of musical expertise. The findings are outlined in relation to other forms of hallucinatory experience and inner music, and their implications for psychological models of hallucinations discussed. 1. Introduction Auditory hallucinations (AH) are defined as the conscious experience of sounds that occur in the absence of any actual sensory input. -
Aubinet-The-Craft-Of-Yoiking-Revised
Title page 1 The Craft of Yoiking Title page 2 The Craft of Yoiking Philosophical Variations on Sámi Chants Stéphane Aubinet PhD thesis Department of Musicology University of Oslo 2020 Table of contents Abstract vii Sammendrag ix Acknowledgements xi Abbreviations xv Introduction 1 The Sámi 2 | The yoik 11 [Sonic pictures 17; Creation and apprenticeship 22; Musical structure 25; Vocal technique 29; Modern yoiks 34 ] | Theoretical landscape 39 [Social anthropology 46; Musicology 52; Philosophy 59 ] | Strategies of attention 64 [Getting acquainted 68; Conversations 71; Yoik courses 76; Consultations 81; Authority 88 ] | Variations 94 1st variation: Horizon 101 On the risks of metamorphosis in various practices Along the horizon 103 | Beyond the horizon 114 | Modern horizons 121 | Antlered ideas 125 2nd variation: Enchantment 129 On how animals and the wind (might) engage in yoiking Yoiks to non-humans 131 | The bear and the elk 136 | Enchantment and belief 141 | Yoiks from non-humans 147 | The blowing of the wind 152 | A thousand colours in the land 160 3rd variation: Creature 169 On the yoik’s creative and semiotic processes Painting with sounds 171 | The creation of new yoiks 180 | Listening as an outsider 193 | Creaturely semiosis 200 | The apostle and the genius 207 vi The Craft of Yoiking 4th variation: Depth 213 On the world inside humans and its animation Animal depths 214 | Modal depths 222 | Spiritual depths 227 | Breathed depths 231 | Appetition 236 | Modern depths 241 | Literate depths 248 5th variation: Echo 251 On temporality