INDEX

Volume 270, July-September, 1994

A69024, effects on cocaine seif-administra- prostatic, in human, canine and rat, 722 characterization of muscarinic recap- tion, in rat, 209 alpha-2 tars mediating acetylcholine-induced A71623, N-acetyl derivative, contractile ef- effects in kappa agonist-induced di- contraction and relaxation in rabbit fecta, in guinea pig ileum, 734 uresis, in rat, 244 intrapulmonary arteries, 269 Abrahams, T. P., Hornby, P. J. Chen K., mediation of rilmemdine sympathoin- Amantadine, renal transport, in rat, 979 Taveira DaSilva A. M. and Gills R. hibition by, 572 1-Aminobenzotriazole A.: The non-NMDA subtype of excit- multiple subtypes, 946, 958 inhibition of pulmonary P450 2Bx by, in atory amino acid receptor plays the rat 946, 958 guinea pig, 377 major role in control of cardiovascu- signaling pathways, in guinea pig duo- N-aralkylated derivatives, inhibition of lax function by the subretrofacial nu- denum, 788 pulmonary P450 2Bx by, in guinea dens in cats, 424 spinal interactions, 1301 pig, 377 Abruscato, T. J., see Brownson, E. A., 675 beta ‘y-Aminobutyric acid-evoked chloride cur- ABT 418 antagonist 5-HT responses, in rents, neurosteroid effects on, 1223 in vitro effects, 310 Chinese hamsterlung fibroblasts and -y-Aminobutyric acidA receptors in uiuo effects, 319 opossum renal epithelial cells, 938 anesthetic potency and, 987 ACA, see N-(p-Amylcinnamoyl)anthranilic endotheial, mediation of NE-induced effects on benzodiazepine efficacy, 485 acid vasodilation by, in rat, 520 ethanol effects on, mouse, 61 Acetaminophen, sulfation, molybdate liii- kinase effects in kappa receptor desen- [3H]TBOB binding, quantitative autora- pairment of, in rats, 1145 sitization, 1381 diography of, 362 N-Acetyl A71623, contractile effects, in triinetoquinol analog partial agonists, 1-Aminocyclopropanecarboxylic acid, dif- guinea pig ileum, 734 665 ferential effects, in punishment pro- Acetylcholine beta-3, agonist effects on antral ulcers, in cedure, 528 contractile and relaxant effects, musca- rat, 559 2-Amino-7-phosphonoheptanoic acid, dif- rinic receptors mediating, in rabbit Adrenocortical secretion ferential effects, in punishment pro- intrapulmonary arteries, 269 5-HT agonist effects on, 905 cedure, 528 extracellular levels, cholinesterase inhib- 5-HT2 agonist effects on, 918 [‘4C]-Aminopyrine, accumulation by pane- itor effects on, in rat, 277 Adrenocorticotropic hormone, pulsatile se- t,al cells, effects of cytokines on, in hippocampal efflux, 5-HT receptor ef- cretion, cocaine effects on, in men, canine, 440 fecta on, in guinea pig, 656 1134 Amnesia, dizodilpine, MDRC agonist effects pulmonary edema induced by, effects of Aging, effects on NE-induced vasodilation, on, 89 CGRP on, in rabbit, 30 in rat, 520 Amphetamines, see also Methamphetamine Acetylcholine receptors, see Muscarinic Agranulocytosis, vesnarinone-induced, 865 neurotoxicity receptors; Nicotinic receptors Aguayo, L G. and Pancetti, F. C.: Ethanol profiles, in C57BL/6J mouse, 741 NaAcetylCyclO(S,S)y8teinylNamethy modulation of the #{176}y-aminobutyric temperature effects on, in C57BL/6J larginyl-glycyl-aspartyl-penicffla- acidA- and glycine-activated C1 cur- mouse, 752 mine-amide, see SK&F 109760 rent in cultured mouse neurons, 61 ventral tegmental area, sensitization of (-)-4R-6-Acetyl-4-(di-n-propylamino)-1,3, Airways nucleus accumbens amphetamine lo- 4,5-tetrahydrobenz[c,dJindole, see PDE inhibitor effects in, in guinea pigs, comotor effects by, 690 LY293284 250 N-(p-Amylcinnamoyl)anthnanilic acid, ef- Action potential duration, human, effects of tachykinin receptors in, in guinea pigs, fects on AVP effects in rat insulin- class III drugs on, 460 1295 oma cells, 900 Adams, P., see Arneric, S. P., 310 Akunne, H. C., see Rothman, R B., 296 Amylin Adenosine, role in hemorrhagic hypoten- Akuzawa, S., see Nishida, A., 1256 binding sites, in rat brain, 779 sion, 589 Alatriopril, effects on cardiac hypertrophy cross-reactivity with CGRPa receptors, Adenosine analogs, relaxant effects of, role and hormonal responses, comparison 779 ofendothelium in, in rat renal artery, with captopril, in rats, 8 Analgesia 893 Albin, R. L., see Sakurai, S. Y., 362 alpha agonist, in amphibians, 540 Adenosine 3-phosphate 5-phosphosulfate, Albuquerque, E. X., see Pereira, E.F.R., 768 mu opioid, enhancement of, in suspended depletion by molybdate, in rats, 1145 Alcohol, see Ethanol mice, 1177 Adenosine receptors, renal artery, in rat, 893 Aldasoro, M., see Martinez, M. C., 622 spinal alpha-2 adrenergic interactions in, Adenosine triphoaphate Alkondon, M., see Pereira, E.F.R., 768 1301 dopamine release stimulation by, ethanol Allan, C. J. and Halushka, P. V.: Character- Anandamide, pharmacological activity, in inhibition of, 336 ization of human peripheral blood mice, 219 nilutamide effects on, 167 monocyte thromboxane A2 receptors, Anaphylaxis, pulmonary, Ro 25-1553 ef- Adrenal medullary cells, Ca/calmodulin- 446 fects in, 1289 dependent protein kinase regulation Allopregnanolone, antagonist effects on di- Anderson, D. J., see Anneric, S. P., 310 of Na-Ca exchange in, in bovine, zocilpine amnesia, 89 Anesthetic potency, and GABAA receptors, 104 987 Adrenoceptors methyl-1-piperazinyl)-3-hydroxy- Angelastro, M. R., see Durham, S. L., 185 a’pha, agonist analgesic effects, in am- benzyl)-N,N-diethylbenzamide dihy- Angiotensin converting enzyme, rate con- phibians, 540 drochloride, see BW373U86 stants in vivo, 260 alpha-i Almokalant, effects on human action poten- Angiotensin I converting enzyme, inhibitor antagonists, modulation of vasocon- tial duration, 460 effects on cardiac hypertrophy and stricter effects of NArg by, in rabbit, Altiere, R J., Travis, D. C., ROberts, J. and hormonal responses, in rats, 8 1152 Thompson, D. C.: Pharmacological Angiotensin H receptors 1398 lndsx 1399

antagonist modulation of renal vasocon- phosphatidylinositol cycle markers, PD 128483 in combination with cocaine strictor effects of NAng, in rabbit, 70 effects on, 1049 1152 ATP, see Adenosine triphosphate Behavioral activation, unit responses to 5- HT agonist and antagonist drugs cardiac SubtypeS, in bovine and human Atrial flutter, effects of procainamide and ventricular myocardium, 566 propafenone on excitable gap in, in during in cats, 1345 Anion transport, renal, stereoselective, in canine, 47 effects ofputative 5-HT antagonists on, rat, 329 Atrial reentry tachycandia, effects of pro- An.isotonic solutions, effects on epithelial cainamide and propafenone on excit- in cats, 1359 Behavioral sensitization, see also Desensiti- transport of hydrophilic compounds, able gap in, in canine, 47 in human, 1373 Atriopeptidase, inhibitor effects on cardiac zation Ansay, M., see Delaunois, A., 30 hypertrophy and hormonal re- amphetamine, 690 binge cocaine, 1387 Anteriorpituitary gland, ET-induced cAMP spouses, in rats, 8 cocaine, genetic analysis, 1230 accumulation in, in rat, 55 AU1akh, C. S., Mazzola-Pomietto, P., Woz- opioid, during intestinal inflammation, in Antiarrhythmic drugs niak, K. M., Hill, J. L and Murphy mice, 386 class Ill, effects on human action poten- D. L.: Evidence that 1-(25-dime- Beinborn, M., see Nompleggi, D. J., 440 tied duration, 460 thoxy-4-methylphenyl)-2-aminopro- Belica, P. S., see Nims, R W., 348 KT-362, 851 pane-induced hypophagia and hyper- Belknap, J. K., see Tolliver, B. K., 1230 Anticoagulation, warfarin, target-based thermia in rats is mediated by sero- Bell, G. I., see Raynor, K., 1381 pharmacokinetics, in rat, 554 tonin-2A receptors, 127 Auta, J., Giusti, P., Guidotti, A. and Costa, Bemesetron, mediation of DOM effects by, Antidepreasants, see Tnicycic antidepres- in rats, 127 santa E.: Imidazenil, a partial positive al- losteric modulator of GABAA recep- Bend, J. R., see Knickle, L C., 377 Antigens, hepatic, halothane-induced, 1325 Benovic, J., see Raynor, K., 1381 Antinociception tors, exhibits low tolerance and de- pendence liabilities in the rat, 1262 Benzazepine, dopamine D-1 antagonist ef- mediated by enkephalin, CCK B antago- fecta on cocaine self-administration, iiist effects on, 77 Autoradiography of amylin binding sites, in rat brain, 779 209 apinal clonidine, 1301 quantitative, of [3HJTBOB binding, 362 Benzodiazepines, efficacy, effects of chronic Antipsychotic drugs, differential effects on Autore, G., see Gaginella, T. S., 1239 flurazepam on, 485 neurotensin systems, 192 Avidin-biotin hemoperfusion systems, in Benzoylecgonine, fetal hemodynamic re- Antithrombotic agents, SK&F 106760, 614 rats, 356 sponse, in lambs, 118 Mitral ulcers, effects of beta-3 agonists on, 3-(4-Benzyl-piperaznyl)-1-cyclobutyl-1-hy- in rat, 589 AVP, see Arginine vasopressin Awad, J. A., Bunk, R F. and Roberts, L J. droxy-1-phenyl-2-propanone, see Anxiolytics, ABT 418, 310, 319 II: Effect of selenium deficiency and NPC-14695 Aorta glutathione-modulating agents on di- Berryer, P., see Ryan, J. W., 260 NE-induced vasodilation, mediation by quat toxicity and lipid peroxidation Berson A. Schmets, L Fiech C., Fau D. beta receptors, in rat, 520 in rats, 858 Wolf C. Fromenty B., Deachamps D. smooth muscle energy-force coupling in, and Pesaayre D.: Inhibition by nilu- in rabbit, 708 Awane, Y., see Ikeda, S., 728 Ayajiki, K., Okamura, T. andToda, N.: Neu- tamide of the mitochondrial reapira- Apamin-sensitive pituitary adenylate cy- rogenic relaxations caused by nic- tory chain and ATP formation. Poe- clase activating peptide receptors, otine in isolated cat middle cerebral sible contribution to the adverse ef- transmission in tenia by, 433 arteries, 795 fects of this antiandrogen, 167 Aquaresis, E2078, in human, 342 Bertaccini, G., see Poli, E., 788 1--d-Arabinofuranceylcytoalne, effect on Baclofen, effects on calcium channel cur- Bervoets, K., see Milan, M. J., 958 drug resistance, effect of dipyrida- rents, in rat, 466 Beta adrenergic receptor kinase, effects in mole on, 480 Balfag#{243}n,G., see Arribas, S., 520 kappa receptor desensitization, 1381 Arachidonylethanolamide, see Anandamide Barbital, pharmacodynamics of hepatic Bicarbonate-dependent amantadine trans- Argenti, D. and D’MeUo, A.: The pharma- CYP2B induction by, in rat, 348 port, in rat renal tubules, 979 codynamics of desipramine and des- Barbiturates, 5,5-diphenyl- and 5,5-diethyl- Biedler, J. L., see Standifer, K. M., 1246 methyldesipramine in rats, 512 substituted, pharmacodynannics of Biliary lipids, effects of lovastatin on, in Arginine vasopreesin, effects in rat insulin- hepatic CYP2B induction by, in rat, humans, 841 oma cells, inhibition by U-73122, 900 348 Billingaley, M. L, see Burkhart, K. K., 356 Arginine’-vasopreasin, ethanoltolerance by, BARK, see Beta adrenergic receptor kinase Biotinylated antibodies, avidin hemoperfu- 5-HT2 receptor effects in, 802 Barker, F. Ill, see Pang, K. S., 285 sion system, in rats, 356 Arita, M., see Cheng, Y.-N., 851 Baron, C. B., see Matsumoto, H., 708 Biotransformation, DCE, by CYP2E1, in Arneric, S. P., see Decker, M. W., 319 Barrett, J. E., see Foreman, M. M., 1270 mice, 371 Arneric S. P., Sullivan J. P. Briggs, C. A. Baumann, M. H., see Rothman, R B., 296 BisaCOdyl, mediation by nitric oxide, 1239 Donnelly-Roberts D., Anderson D. J. Bay K 8644 Bixler, M. A., see Winsauer, P. J., 142 Raszkiewicz, J. L Hughes M. L, Cad- effects in ajpha-2 adrenoceptor signaling, Black, S. C., Schasteen, C. S., Weiss R. H., man E. D. Adams, P. Garvey D. S., in guinea pig duodenum, 788 Riley D. P. Driscoll, E. M. and Luc- Wasicak J. T. and Williams M.: (S)- effects in H3 receptor signaling, in guinea chesi B. It: Inhibition of in vivo myo- 3-Methyl-5-(1-methyl-2-pyrrolidinyl pig duodenum, 788 cardial ischemia and reperfusion in- Beard, D., see Burkhart, K. K., 356 jury by a synthetic manganese-based isoxazole (ABT 418), 310 BE(2)-C neuroblastoma cells, opioid recep- superoxide dismutase mimetic, 1208 Arribas, S., Marin, J., Ponte, A., Balfag#{243}n, tors in, 1246 Black Americans, erythrocyte COMT activ- G. and Salaices, M.: Norepinephrine- Behavior ity, ethnic differences, 26 induced relaxations in rat aorta me- BW373U86 effects on, in rhesus monkeys, Blom-Rooeemalen, M.C.M., see Noach, diated by endothelial beta adrenocep- 1025 A.B.J., 1373 tors. Impairment by aging and hyper- chiorpyrifos effects on, in rats, 15 Blood, see Peripheral blood tension, 520 intrathecal nicotine effects on, 150 Blood brain barrier, enkephalin permeabil- Asthma, Ro 28-1583 effects in, 1289 low dose cocaine effects on, 1041 ity, effects of peptidases on, 675 AtaCk, J. R., Prior, A. M., Fletcher, S. R, motor, effects of rat adrenocep- Blood flow, gastric mucosal, beta-3 agonist Quirk, K., McKernan, R. and Ragan tors in, 958 enhancement of, effects on antral ul- C. L: Effects of L-690488, a prodrug nalmefene effects on, in rhesus monkeys, cars, in rat, 559 of the bisphosphonate inositol mon- 992 Blood pressure ophosphatase inhibitor L-690330 on PD 128483 effects on, 1049 caffeine effects on, in hypertension, 1063 1400 Index Vol. 270

ETA and ETB-med’ated responses, inhi- Buckley, M. J., see Decker, M. W., 319 N-type bition by TAK-044, in rat, 728 Buhi, W. C., see Salhab, A. S., 392 effects in a4,ha-2 adrenoceptor signal- non-NMDA BAA receptor effects on, in Burcher, E., see Zeng, X.-P., 1295 ing, in guinea pig duodenum, 788 cats, 424 Burdette, D. E., see Sakurai, S. Y., 362 effects in H3 receptor signaling, in Bloomquist J. King E., Wright A. Mytili- Burk, R. F., see Awad, J. A., 858 guinea pig duodenum, 788 neou, C. Kimura K., Castagnoli K. Burkhart, J. P., see Durham, S. L, 185 opioid effects on, in rat, 466 and Castagnoli N., Jr.: i-Methyl-4- Burkhart, K. K., Beard, D. and Billingsley, voltage-sensitive phenylpyridinium-like neurotoxicity M. L.: Enhanced elimination of bio- in cardiomyocyte hypertrophy, 697 of a pyridinium metabolite derived tinylated antibodies by avidin-based effects in ameliorating effects of nefi- from haloperidol: Cell culture and hemoperfusion in rats, 356 racetam, 881 neurotransmitter uptake studies, 822 Burn, K., see Clozel, M., 228 Calcium/calmodulin-dependent protein ki- BMY 7378, effects on serotonergic unit ac- Bushnell, P. J., Kelly, K. L and Ward, T. nase tivity, in behaving cats, 1359 R.: Repeated inhibition of cholines- inhibitors, myocardiac effects, in fetal Boada, L. D., see Fern#{225}ndez, L., 1121 terase by chlorpyrifos in rats: Behav- mouse, 1319 Bochnowicz, S., see Underwood, D. C., 250 ioral, neurochemical and pharmaco- regulation of Na-Ca exchange by, in BOF-4272, pharmacokinetic and pharma- logical indices of tolerance, 15 bovine adrenal medullary cells, 104 codynamic properties, 453 Buspirone, unit responses to, in behaving Caldwell J. E. Szenohradszky J., Segredo V. Bolin, D. R., see O’Donnell, M., 1282; cats, 1345 Wright, P.M.C. McLoughlin C., O’Donnell, M., 1289 Butelman, E. R., see Negus, S. S., 1025 Sharma M. L. Gruenke, L D. Fisher Bolton Hunter-rat amylin, binding sites, in Butler, A. M., see Murray, M., 645 D. M. and Miller, R. D.: The phar- rat brain, 779 Butorphanol, subjective, psychomotor and macodynamics and pharmacoki- Booher, R. N., see Foreman, M. M., 1270 physiological effects, comparison netics of the metabolite 3-desacetyl- Boppana, V., see Nichols, A. J., 614 with morphine, in healthy volun- vecuronium (ORG 7268) and its par- Bosentan, pharmacological characteriza- teers, 579 ent compound vecuronium, in human tion, 228 [3H]t-Butylbicycloorthobenzoate, quantita- volunteers, 1216 Bouaziz, H., see Lothe, A., 1301 tive autoradiography of, 362 Calligaro, D. 0., see Foreman, M. M., 1270 Bowen, W. D., see Miyamoto, Y., 37 BW373U86, behavioral effects, in rhesus Cancer, ethacrynic acid pharmacokinetics BQ-123, inhibition of renal vasoconstricton monkeys, 1025 and bioavailabiity in, 1186 by, 269 Candura, S. M., see Ciccocioppo, R., 929 Caco-2 cells Bradykinin, role in myocardial precondi- Cannabinoids, endogenous, pharmacologi- cephalosporin transport in, 498 tioning, 681 cal activity, in mice, 219 hydrophilic compound transport across, Brain Capasso, F., see Gaginella, T. S., 1239 effects of anisotonic solutions on, amylin binding sites, in rat, 779 Captopril 1373 effects on cardiac hypertrophy and hor- uptake of [mnI13,3F,5T3 in, inhibition by Cadet, J. L., see Rothman, R. B., 296 desmethylimipramine, in rats, 111 monal responses, comparison with Cadman, E. D., see Arneric, S. P., 310 Bralet J. Marie C., Mossiat C. Lecomte, J.- alatriopril, in rats, 8 Cadmium, metallothionein cytoprotection M. Gros C. and Schwartz, J.-C.: Ef- against, IL-ifi effects on, 1313 renal hemodynamic effects, comparison fecta of alatriopril a mixed inhibitor with ramiprilat, 491 Caffeine of atriopeptidase and angiotensin-I 5-Carboxamidotryptamine, vasoconstrictor effects on Ca interactions between tro- converting enzyme on cardiac hyper- ponin subunits from bovine hearts, effects, in rabbit renal arteries, 650 Cardiac hypertrophy, effects of alatriopril trophy and hormonal responses in 831 rats with myocardial infarction. Com- effects on hypertension, 1063 on, comparison with captopril, in parison with captopril, 8 Caggiula, A. R., see Perkins, K. A., 628 rats, 8 Brase, D. A., see Smith, F. L., 1177 Cai, J. J., see Lee, H.-C., 1171 Cardiac myocytes Breimer, D. D., see Noach, A.B.J., 1373 Caine, S. B. and Koob, G. F.: Effects of KN-62 effects on, in fetal mouse, 1319 Brennan, J. M., see Lacreta, F. P., 1186 dopamine D-1 and D-2 antagonists KT-362 effects on ion currents in, in Brenner, G. M., Klopp, A. J., Deason, L. L. on cocaine self-administration under guinea pig, 851 and Stevens, C. W.: Analgesic po- different schedules of reinforcement Cardiomyocyte hypertrophy tency ofalpha adrenergic agents after in the rat, 209 1,4-dihydropyridine binding sites in, 697 systemic administration in amphibi- Calcitonin gene-related peptide, effects on effects of PKC on phosphodiesterase in, ans, 540 pulmonary edema, in rabbit, 30 in hamster hearts, 1171 Breu, V., see Clozel, M., 228 Calcitonin gene-related peptide-a receptors, voltage-sensitive calcium channels in, 697 Breuiller-Fouch#{233}, M., H#{233}luy, V., Fournier, human, cross-reactivity with rat Cardiorespiration, epibatidine effects on, T. and Ferr#{233},F.: Endothelin recep- amylin, 779 702 tore: Binding and phosphoinositide Calcium Cardiovascular system breakdown in human myometrium, esophageal smooth muscle fluxes, inhibi- intrathecal nicotine effects on, 150 973 tion by acute ethanol, 1057 subretrofacial nucleus control, non- Brigge, C. A., see Arneric, S. P., 310 intracellular NMDA EAA receptor effects on, in Brioni, J. D., see Decker, M. W., 319 AVP-stimulated increase, in rat insu- cats, 424 BRL 52974, diuretic effects, in rat, 244 linoma cells, 900 Carney, J. M., see Tolliver, B. K., 1230 BRL 53117, diuretic effects, in rat, 244 effects of opioid delta receptors on, in Carnitine transport, cephaloridine toxicity Bronchodilation NDS-47 cells, 40 to, in rabbit renal cortical mitochon- NPC-14695, 546 lindane effects on, in rat myometrial dna, 873 Ro 25-1553, 1282 smooth muscle cells, 1015 Carroll, F. I., see Rothman, R. B., 296 Bronchospasm, PDE inhibitor effects on, in xo effects on, in vascular endotheial Cassal, J.-M., see Clozel, M., 228 guinea pigs, 250 cells, 1197 Castagnoli, K., see Bboomquist, J., 822 Bronchus, tachykinin receptors in, in guinea sodium exchange, regulation by Ca/cal- Catagnoli, N., Jr., see Bboomquist, J., 822 pig, 1295 modulin-dependent protein kinase, Catechol-O-methyltransferase, erythrocyte Brooks, A. I., see Standifer, K. M., 1246 in bovine adrenal medullary cells, 104 activity, ethnic differences, 26 Brooks, D. P., see Wang, Y.-X., 244 Calcium blockers, intracellular, KT-362, Cation transport, renal, in rat, 979 Brownson, E. A., Abruscato, T. J., Gillespie, 851 Catravas, J. D., see Ryan, J. W., 260 T. J., Hruby, V. J. and Davis, T. P.: Calcium channels Caucasians Effect of peptidases at the blood IP-sensitive, release by lindane, in rat erythrocyte COMT activity, ethnic differ- brain barrier on the permeability of myometrial smooth muscle cells, ences, 26 enkephalin, 675 1015 interindividual P450 variations, 414 1994 lndsx 1401

Caudate membranes, multiple [mnI]RTI55 GABA-evoked, neurosteroid effects on, in combination with PD 128483, behav- binding sites in, in rat, 296 1223 ioral effects, 1049 CCK, see Cholecystokinin GABAA-activated differential effects on neurotensin sys- Cederbaum, A. I., see Wu, D., 407 anesthetic potency and, 987 tems, 192 Central nervous system ethanol effects on, in mouse, 61 effects on pulsatile ACTH secretion, in BAA receptors, blood pressure effects, in glycine-activated, ethanol effects on, in men, 1134 cats, 424 mouse, 61 fetal hemodynamic response, in lambs, intrathecal nicotinic receptors, cardiovas- 7-Chlorokynurenic acid, differential effects, 118 cular and behavioral effects, 150 in punishment procedure, 528 locomotor effects, in inbred mice, 1230 methamphetamine effects on, role of 5- m-Chlorophenyliperazine, hyperthermic ef- low dose, discriminative stimulus effects, HT2 receptors in, 97 fects, tolerance to, in rats, 127 1041 Cephaloridine, toxicity to carnitine trans- Chlorpyrifos, repeated inhibition of cholin- self-administration port, in rabbit renal cortical mito- esterase by, tolerance indices, in rats, effects ofdopamine D-1 and D-2 antag- chondria, 873 15 onists on, in rat, 209 Cephalosporins, oral, transport in Caco-2 Cholecystokinin A receptors, agonist con- interactions with dopamine effects on cells, 498 tractile effects, in guinea pig ileum, prolactin, in female rhesus monkeys, Cerebral arteries 734 1110 nicotine relaxation of, in cat, 795 Cholecystokinin B receptors, antagonist ef- sensitization and tolerance to, genetic vasopressin and desmopressin effects in, fects on antinociception mediated by analysis, 1230 in human, 622 enkephalins, 77 Cocaine analogs, RTI-55, multiple binding Cerebral blood flow, fetal response to co- Choleithiasis, effects of lovastatin on, in sites, in rat, 296 caine, cocaethylene and benzoylec- humans, 841 Coccini, T., see Ciccocioppo, R, 929 gonine, in lambs, 118 Cholesterol, effects of lovastatin on, in hu- Cognition, ABT 418 enhancing effects on, Cerebral cortex, see also Frontal cortex mans, 841 310, 319 neurons, GABAA receptor effects on ben- Cholinergic channel activators, ABT 418, Cognitive deficits zodiazepine efficacy, 485 310, 319 dizocilpine, neurosteroids antagonism of, neurotransmitters, cholinesterase inhibi- Cholinesterase, repeated inhibition by 89 tor effects on, in rat, 277 scopolamine-induced, calcium channelef- chlorpyrifos, tolerance indices, in rat RA,,IGIA adrenoceptors, comparison facts in amelioration by nefiracetam, rats, 15 with other alpha-2 populations, 946 881 Cholinesterase inhibitors CGRP, see Calcitonin gene-related peptide Colon, neurogenic inhibition in, in rabbit, effects in rats, 277 Chang, H., see Donnelly, R, 809 effects on MPTP neurotoxicity, 639 929 Chang, K.-J., see Negus, S. S., 1025 Choppin, A. and O’Connor, S. E.: 5- Colonic cells, transport of hydrophilic com- Chang, S. L, see Zadina, J. E., 1086 pounds across, effects of anisotonic HydroxytryptaminelD-like receptors Chemotherapy, resistance to, effect of di- solutions on, in human, 1373 mediate contraction of partially de- pyridamole on, 480 Comis, R L, see Lacreta, F. P., 1186 polarized rabbit renal arteries, 650 Chen, C.-S., see Chen, C.-Y., 1307 Compton, D. R., see Smith, P. B., 219 Chou, J. M., see Scott, P. A., 198 Chen, C.-Y., Pang, V. F. and Chen, C.-S.: Congestive heart failure, effects of alatrio- Chung, A.Y.K., see Ryan, J. W., 260 Assessment of ibuprofen-associated pril on, comparison with captopril, in Ciccocioppo, R, Onori, L, Messori, E., Can- nephrotoxicity in renal dysfunction, rats, 8 dura, S. M., Coccini, T. and Tonini, 1307 Contractions, see also Vasoconstriction M.: Role of nitric oxide-dependent Chen, K., see Abrahams, T. P., 424 acetyicholine-induced, muscarinic recap- and -independent mechanisms in Chen, K. and Zimmerman, B. G.: Compari- tore mediating, in rabbit intrapul- peristalsis and accommodation in the son of renal hemodynamic effect of monary arteries, 269 rabbit distal colon, 929 ramiprilat to captopril: Possible role cholecystokinin A receptor, in guinea pig Cimetidine, transepithelial flux, effects of of kinins, 491 ileum, 734 Chen, T.-H. Lee B. and Hsu, W. H.: Argi- P-glycoprotein on, in MDCK cells, 1 TXA2-induced, inhibitory effects of hy- Circular muscle, distal colon, NANC relax- nine vasopressin-stimulated insulin droxy fatty acids on, 1105 ation, nitric oxide mechanisms in, secretion and elevation of intracell- Convulsions, corticosterone effects on, mm- 929 ular Ca4 concentration in rat in- eralocorticoid receptors mediation of, Clarke, G. D., see Wang, Y.-X., 244 sulinoma cells: Influences of a in mice, 505 Clonidine phoapholipase C inhibitor 1-6-17- Corpus striatum, dopamine release in analgesic effects, in amphibians, 540 methoxyestra-135(i0)-trien-17-yl- effects of chronic cocaine on, in rats, 133 spinal effects, 1301 aminojhexyl]-1H-pyrrole-2,5-dione 5-HT-induced, in rats, 1158 (U-73122) and a phospholipase A2 Clozapine, differential effects on neuroten- restoration by fetal mesencephalic grafts, inhibitor N-(p)amilcinnamoyl an- sin systems, 192 in rat striatum, 814 thranilicacid, 900 Clozel M. Breu, V. Gray G. A., Kalina B. Corsi M. Palea S., Pietra C. Oliosi, B. Gay- Chen, X.-L, see Ryan, J. W., 260 Loffler, B.-M. Burn K., Cassal J.-M. iraghi G., Sugg E. Van Amsterdam, Cheney, D. L., see Romeo, E., 89 Hirth, G. Muller M., Neidhart W. F.T.M. and That D. G.: A further Cheng, J., see Standifer, K. M., 1246 and Ramuz H.: Pharmacological analysis of the contraction induced Cheng, Y-N., Kiyoeue, T. and Arita, M.: characterization of bosentan, a new by activation of cholecystokinin A Effects of KT-362, a new antiar- potent orally active nonpeptide en- receptors in guinea pig isOlated il- rhythmic agents, on membrane ionic dothelin receptor antagonist, 228 eum longitudinal muscle-myenteric currents of guinea pig ventricular Coalson, D. W., see Zacny, J. P., 579 plexus, 734 myocytes, 851 Coburn, R. F., see Matsumoto, H., 708 Corticosterone effects on convulsions, min- Chevalier, E., see Rivi#{232}re,P.J.M., 846 Cocaethylene, fetal hemodynamic response, eralocorticoid receptors mediation of, Chinese hanisterlung fibroblasts, cellular 5- in lambs, 118 in mice, 505 HT1 responses, 938 Cocaine mediation of morphine-suppressed nato- Chirino, R., see Fern#{225}ndez,L., 1121 binge administration ml killer cell activity by, 1127 Chioramphenicol, suppression ofP45O 2C11 behavioral sensitization during, 1387 Corticotropin releasing factor receptors, ef- by, in rat, 1367 dopamine receptor up-regulation dur- fects in ileus, in rats, 846 Chiordiazepoxide, effects on radiation-in- ing, 1387 Costa, E., see Auta, J., 1262 duced decreases in food intake, in chronic Costa, E., see Romeo, E., 89 rats, 142 effects on dopamine uptake, in rats, 133 Courjault-Gautier, F., Host, D., Leroy, D. Chloride channels effects on placenta, in rats, 392 and Toutain, H. J.: Dissimilar alter- 1402 Index Vol. 270

ations of sodium-coupled uptake by Daaka, Y., see Zhu, W., 1334 DIaz-Chico, B. N., see Fern#{225}ndez,L., 1121 platinum-coordination complexes in DAMGO DIaz-Chico, J. C., see Fern#{225}ndez, L., 1121 renal proximal tubular cells in pri- effects on calcium channel currents, in Diazepam mary culture, 1097 rat, 466 differential effects, in punishment proce- Covert, R. F., Schreiber, M. D., Tebbett, I. intrathecal, analgesic effects, enhance- dare, 528 R and Torgerson, L. J.: Hemody- ment of, in suspended mice, 1177 efficacy, effects of chronic flurazepam on, namic and cerebral blood flow effects Danziger, R., see Ujiie, K., 761 485 of cocaine, cocaethylene and benzoy- Davis, T. P., see Brownson, E. A., 675 Diazepam-binding inhibitor, mitochondrial lecgonine in conscious and anesthe- DBCA, see 5-Dimethylsulfamoyl-6,7-di- receptor complex, agonist effects on tized fetal lambs, 118 chloro-2,3-dihydrobenzofuran-2-car- dizocilpine amnesia, 89 Cox, B. M., see Tang, T., 40 boxylic acid 1,1-Dichloroethylene, CYP2E1 biotransfor- CPA, see N6-Cyclopentyladenosine DCE, see 1,1-Dichioroethylene mation of, in mouse liver, 371 CRF, see Corticotropin releasing factor de Boer, A. G., see Noach, A.B.J., 1373 trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1- Criswell, K. A., Stuenkel, E. L. and Loch- de Costa, B. R., see Rothman, R B., 296 pyrrolydinyl)-cyclohexyl]-benzene- Caruso, R.: Lindane increases intra- de Jonge, H. R., see Noach, A.B.J., 1373 acetamide methanesulfonate, see (± cellular calcium in rat myometrial Deamino-8-d-arginine vasopressin, see Des- )U-50,488H smooth muscle cells through modu- mopressin 1-[(3,4-Dichlorophenyl)acetyll-2-[(3-hy- lation of inositol 1,4,5-trisphosphate- Deason, L. L., see Brenner, G. M., 540 droxy-1-pyrrolidinyl)methyl]-4,4-di- sensitive stores, 1015 Decker M. W., Brioni J. D. Sullivan, J. P. methyl piperidine, see BRL 53117 Cross-reactivity, between human CGRPCX Buckley M. J., Radek R. J. Raszkiew- 5-[(3,4-Dichlorophenyl)acetyl]-4-(1-pyrrol- receptors and rat amylin, 779 icz, J. L. Kang C. J., Kim D.J.B. idinylmethyl)-4,5,6,7-tetrahydro-1H- Cross-talk, between PKC and cAMP path- Giardina, W. J. Wasicak J. T., imidazo[4,5-c]pyridine, see BRL ways, in hypertrophic cardiomy- Garvey D. S. Williams, M. and Ar- 52974 opathic hamster hearts, 1171 neric S. P.: (S)-3-Methyl-5-(1- 5,5-Diethylbarbituric acid, see Barbital 5-CT, see 5-Carboxamidotryptamine methyl-2-pyrrolidinyl)isoxazole 5,5-Diethylhydantoin, pharmacodynamics Cuadra, G., Summers, K. and Giacobini, E.: (ABT 418), 319 of hepatic CYP2B induction by, in DeCosta, B., see Negus, 1025 Cholinesterase inhibitor effects on S. S., rat, 348 neurotransmitters in rat cortex in Delaunois, A., Gustin, P. and Ansay, M.: 8-[2-(2,3-Dihydro-1,4-benzodioxin-2-yl- vivo, 277 Modulation of the acetylcholine- and methylamino)ethyl]-8-azaspiro[4,5]- Cyclic AMP, ET-induced accumulation, in substance P-induced pulmonary decane-7,9-dione methyl sulphonate, rat anterior pituitary gland, 55 edema by calcitonin gene-related see MDL 73005 Cyclic AMP-dependent phosphodiesterase, peptide in the rabbit, 30 (R)-1-[2,3-Dihydro-1-(2’-methylphenacyl)- effects of PKC on, in hamster hearts, Dependence, see also Tolerance 2-oxo-5-phenyl-1H-1,4-benzodiaze- 1171 morphine, delta-i opioid receptors in, in pin-3-yl]-3-(3-methylphenyl)urea, Cycbooxygenase-2, regulation by glucocorti- mice, 37 see YM022 coids, in peritoneal macrophages, Dependence liability, imidazenil, in rat, 1,4-Dihydropyridine, binding sites in car- 1340 1262 diomyocyte hypertrophy, 697 N-Cyclopentyladenosine, relaxant effects Derakhchan, K., Page, P., Lambert, C. and 3,4-Dihydroxyphenylalanine, metabolism, of, role of endothelium in, in rat renal Kus, T.: Effects of procainamide and effects of neonatal 6-hydroxydopa- artery, 893 propafenone on the composition of mine on, in rat, 713 Cyclophosphamide, inhibition of P450 3A the excitable gap in canine atrial Diisopropylfluorophosphate, effects on by, in human liver, 645 reentry tachycardia, 47 MPTP neurotoxicity, 639 17-N-Cyclopropylmethyl-3,14-j-dihydroxy- Dersch, C. M., see Rothman, R B., 296 1-(2,5-Dimethoxy-4-iodophenyl)-2-amino- 4,5-a-epoxy-6-methylenemorphinan 3-Desacetylvecuronium, pharmacology, in propane hydrochloride, see Nalmefene human volunteers, 1216 effects on adrenocortical secretion, 918 d-Cycloserine, differential effects, in pun- Descarries, L., see Molina-Holgado, E., 713 vasoconstrictor effects, in rabbit renal ar- ishment procedure, 528 Deschamps, D., see Berson, A., 167 teries, 650 CYP, see Cytochrome P450 Desensitization, see also Sensitization Cytidine monophosphorylphosphatidate, ef- kappa opioid receptor, 1381 1-(2,5-Dimethoxy-4-methylphenyl)-2-ami- nopropane, hypophagic and hyper- fects of L-690,488 on, 70 opioid thermic effects, mediation by 5-HT Cytisine in calcium channel currents, in rat, 466 receptors, in rats, 127 intrathecal, cardiovascular and behav- in SHSY5Y cells, 177 5-[3-[[2-(3,4-Dimethoxyphenyl)ethylj ioral effects, 150 soluble guanylyl cyclase, in rat medullary ligand specificity, in rat spinal cord, 159 interstitial cells, 761 amino]-1-oxopropylj-2,3,4,5-tetrahy- dro-1,5-benzothiazepinefumarate, Cytochrome P450 Desipramine, pharmacodynamics, in rats, 2B, hepatic induction pharmacody- 512 see KT-362 namics, in rat, 348 Desmethyldesipramine, pharmacody- N-(2,6-Dimethylphenyl)-2-(2-oxo-1-pyrrol- 2Bx, pulmonary, inactivation of, in guinea namics, in rats, 512 idinyl) acetamide, see Nefiracetam pig, 377 Desmethylimipramine, inhibition of [‘9j3, 5-Dimethylsulfamoyl-6,7-dichloro-2,3-dihy- 2C11, suppression by chloramphenicol, in 3’,5-T3 brain uptake by, in rats, 111 drobenzofuran-2-carboxylic acid, rat liver, 1367 Desmopressin, effects in human cerebral ar- stereoselective renal secretion, in rat, 2E1 teries, 622 329 DCE biotransformation by, in mouse Detweiler, D. J., see Lothe, A., 1301 Dipeptide transport systems, interaction liver, 371 DeVane, C. L., see Salhab, A. S., 392 with cephalosporin transport, in hu- kidney induction, in rat, 407 Dewar, K. M., see Molina-Holgado, E., 713 man, 498 3A, inhibition by oxazaphosphorines, in Dewey, W. L., see Smith, F. L., 1177 5,5-Diphenylbarbituric acid, hepatic human liver, 645 Dexamethasone, binding sites, induction by CYP2B induction by, pharmacody- interindividual variations, in human liver, ethinylestradiol, in male rat liver, namics of, in rat, 348 414 1121 5,5-Diphenylhydantoin, see Phenytoin Cytokines, recombinant, effects on canine Dexmedetomidine, analgesic effects, in am- Dipyridamole, effect on drug resistance, 480 parietal cells, 440 phibians, 540 Diquat toxicity, F2-isoprostanes in, in rats, Cytotoxicity, cadmium and cis-diammine- cis-Diamminedichloroplatinuzn, metallothi- 858 dichloroplatinum, metallothionein onein cytoprotection against, IL-1$ Diuresis, kappa agonist-induced, in rat, 244 protection against, IL-19 effects on, effects on, 1313 Dizocilpine, differential effects, in punish- 1313 Diarrhea, opioid effects, in mice, 386 ment procedure, 528 1994 Index 1403

Dizocilpine amnesia, MDRC agonist effects Driscoll, E. M., see Black, S. C., 1208 Enkephalins on, 89 Drug resistance antinociception mediated by, CCK B an- DM-9384, see Nefiracetam effect of dipyridamole on, 480 tagonist effects on, 77 D’Mello, A., see Argenti, D., 512 ethacrynic acid-modulated, in patients blood brain barrier permeability, effects DOI, see (±)-1-(2,5-Dimethoxy-4-iodo- with cancer, 1186 ofpeptidases on, 675 phenyl)-2-aminopropane Drugs, see specific drugs and drug tes effects on calcium channel currents, in DOM, see 1-(2,5-Dimethoxy-4-methyl- Duane, W. C.: Effects of lovastatin in hu- rat, 466 phenyl)-2-aminopropane mans on biliary lipid composition Eosinophils, pulmonary influx, PDE inhib- Domae, M., Yamada K., Inoue T. Satoh, M. and secretion as a function of dosage itor effects on, in guinea pigs, 250 and Furukawa T.: Endothelins stim- and treatment interval, 841 Epibatidine, ganglionic depolarizing effects, ulatecycic AMP accumulation in the Duodenum 702 isOlated rat anterior pituitary gland alpha-2 adrenoceptor signaling pathways, Epinephrine, analgesic effects, in amphibi- Possible involvement OfETA receptor in guinea pig, 788 ass, MO activation and prostaglandin E pro- antiulcer effects of YM022 in, in rats, Epithelial cells duction, 55 1256 intestinal Dombrowski, D. S., see Smith, F. L., 1177 H3 receptor signaling pathways, in guinea cephalosporin transport in, in human, Donnelly, R, Plato, P. A., Chang, H. and pig, 788 498 Reaven, G. M.: Effects of gemfibrozil Durham S. L., Hare C. M. Angelastro, M. transport across, effects of tonicity on, on triglyceride metabolism in DaM R. Burkhart J. P., Koehl J. R Mar- in human oolonic cell lines, 1373 salt-sensitive rats, 809 quart, A. L. Mehdi S., Pest N. P. and renal Donnelly-Roberts, D., see Arneric, S. P., 310 Janusz M. J.: Pharmacology of N-4- ETB receptor subtypes in, in porcine Dopamine (4-morpholinylcarbonyl)benzoyl-l- LLC-PK1 cells, 1035 effects on prolactin, interactions with co- prolinamide (MDL 101,146): A po- 5-HT18 responses, in opossum, 938 caine self-administration, in female tent orally active inhibitor of human Erythrocytes, COMT activity, ethnic differ- rhesus monkeys, 1110 neutrophil elastase, 185 ences, 26 extracellular levels, cholinesterase iaMb- Dutt, A., see Pan, B.-F., 1 Escobar, M. R, Wong, LT.Y. and Sitar, D. itor effects on, in rat, 277 Dynorphin A (1-17), effects on spinal cord- S.: Bicarbonate-dependent amanta- metabolism, effects of neonatal 6-hydrox- evoked potentials, pharmacological dine transport by rat renal cortical ydopamine on, in rat, 713 characterization of, 534 proximal and distal tubules, 979 neostriatal synthesis, role of5-HT2 recep- Dynorphin-A analogs, E2078, aquaretic ef- Esophageal smooth muscle, calcium fluxes tore in, 97 fects, in human, 342 in, ethanol inhibition of, 1057 release Dyslipidemia, gemfibrozil effects on triglyc- Ethacrynic acid, pharmacokinetics and bio- effects of chronic cocaine on, in rats, eride metabolism in, in DaM salt- availability study, in patients with 133 sensitive rats, 809 cancer, 1186 5-HT-induced, in rats, 1158 Ethanol E-2078, aquaretic effects, in human, 342 inhibition by D2 and D3 receptors, 475 acute, inhibition ofcalcium fluxes in mus- E-4031, effects on human action potential dc by, 1057 inhibition by ethanol, 336 duration, 460 restoration by fetal mesencephalic effects on GABAA receptors, mouse, 61 EAA receptors, see Excitatory amino acid effects on glycine receptors, mouse, 61 grafts, in rat striatum, 814 receptors inhibition of DA release by, 336 transporters, multiple [1I]RTI-55 bind- Edema, pulmonary tolerance to, 5-HT2 receptor effects in, ing sites for, in rat, 296 effects of CGRP on, in rabbit, 30 802 Dopamine autoreceptors, agonist behavioral effects of furosemide on, comparison with Ethinylestradiol, interaction with liver mi- effects, 1049 morphine, 1077 crosomes, in male rat, 1121 Dopamine receptors Eisenach, J. C., see Lothe, A., 1301 Ethnic differences, in erythrocyte COMT D1 Elastase, oral inhibitor, 185 activity, 26 agonist cocaine drug substitution, 1041 Electrical field stimulation, release of in- 5’-N-Ethylcarboxamidoadenosine, relaxant antagonist effects on cocaine self-ad- flammatory mediators by, in guinea effects of, role of endothelium in, in ministration, in rat, 209 pig trachea, 1166 rat renal artery, 893 D2 Elliott, S. J., see Wesson, D. E., 1197 1,i’-Ethylene-2,2’-dipyridylium, see Diquat agonist cocaine drug substitution, 1041 Endothelial cells, XO effects on Ca sig- Eticlopride, effects on cocaine self-admin- antagonist effects on cocaine self-ad- naling in, 1197 istration, in rat, 209 ministration, in rat, 209 Endothelin, cAMP accumulation induced Evans, W. E., see McLeod, H. L, 26 inhibition of dopamine release by, 475 by, in rat anterior pituitary gland, 55 Evoked potentials, spinal cord, dynorphin A D3, inhibition ofdopamine release by, 475 Endothelin receptors (1-17) effects on, pharmacological up-regulation, binge cocaine, 1387 in human myometrium, 973 characterization of, 534 Dopamine-altering drugs, differential ef- new oral antagonist, 228 Excitable gap, atrial, effects of procaina- fects on neurotensin systems, 192 EndothelinA receptors mide and propafenone on, in canine, Dopaminergic neurotoxicity, MPTP effects on ET-induced cAMP accumula- 47 effects of cholinergic drugs on, 639 tion in anterior pituitary gland, in Excitatory amino acid receptors, non- species sensitivity, 1000, 1008 rat, 55 NMDA, blood pressure effects, in Dorsal raphe nucleus, serotonergic neurons TAK-044 antagonist, 728 cats, 424 in, unit responses to EndothelinB receptors in behaving cats, 1345 subtypes in porcine kidney epithelial Faiman, C. P., Viu, E., Skolnick, P. and effects ofputative 5-HT antagonists on, LLC-PK1 cells, 1035 Trullas, R.: Differential effects of in behaving cats, 1359 TAK-044 antagonist, 728 compounds that act at strychnine- Dorsal root ganglion neurons, opioid effects Endothelium insensitive glycine receptors in a On calcium channel currents in, in beta receptors, mediation of NE-induced punishment procedure, 528 rat, 466 vasodilation by, in rat, 520 Fang, L, see McLeod, H. L, 26 Dorsal root ganglion-neuroblastoma hybrid renal artery, adenosine receptor-mediated Fatty acids ND8-47 cells, effects of opioid delta relaxation of, in rat, 893 hydroxy, inhibitory effects on thrombox- receptors on intracellular-free cal- Endotoxin-stimulated macrophages, THC ane, 1105 cium in, 40 enhancement of ILl secretion in, metabolism of, cephaloridine toxicity to, Dratman, M. B., see Gordon, J. T., 111 1334 in rabbit renal cortical mitochondria, Drewett, J. G., see Ujiie, K., 761 Energy-force coupling, smooth muscle, in 873 Drieze, J. M., see Mellon, N. K., 1110 rabbit aorta, 708 Fau, D., see Berson, A., 167 1404 Index VoL 270

Fedotozine, reversal of ileus by, in rats, 846 Tada K. and Jacobs B. L.: Effects of of, effects of inflammation on, in Feller, D. R., see Fraundorfer, P. F., 665 the putative 5-hydroxytryptaminelA mice, 386 d-Fenfluramine, neurotoxicity profiles, in antagonists BMY 7378, NAN 190 Gaviraghi, G., see Corsi, M., 734 7B6Jmouse, 741 and (-)-propranolol on serotonergic Ge, L.-J., see Zadina, J. E., 1086 Fernandes, L B., Hubbard, W. C. and Un- dorsal raphe unit activity in behaving Gelles, H., see Tech, S. K., 1134 dam, B. J.: Release of inflammatory cats, 1359 Gemfibrozil, effects on triglyceride metabo- mediators from guinea pig trachea by Fournier, A., see van Rossum, D., 779 lism, in Dahl salt-sensitive rats, 809 electrical field stimulation: Lack of Fournier, T., see Breuiller-Fouch#{233}, M., 973 Gepirone, effects on 5-HT1A responses, 198 neuronal involvement, 1166 Fournie-Zaluski, M. C., see Valverde, 0., 77 Gerak, L R., see France, C. P., 992 Fern#{225}ndez,L. Boada L. D., Luzardo 0. P. France, C. P. and Gerak, L R.: Behavioral Giacobini, E., see Cuadra, G., 277 Zumbado, M. Diaz-Chico J. C., DIaz- effects of 6-methylene naltrexone Giacomini, J. C., see Lubic, S. P., 697 Chico B. N. and Chirino R.: Ethiny- (nalmefene) in rhesus monkeys, 992 Giacomini, K. M., see Lubic, S. P., 697 lestradiol interacts with liver micro- Fraundorfer P. F., Fertel R. H. Miller, D. D. Giardina, W. J., see Decker, M. W., 319 somes and induces binding sites for and Feller D. R.: Biochemical and Gibb, J. W., see Gygi, S. P., 192 steroid hormones in the male rat pharmacological characterization of Gibb, J. W., see Johnson, M., 97 liver, 1121 high-affinity trimetoquinol analogs Gilbert, R. S., see Masferrer, J. L., 1340 Ferr#{233},F., see Breuiller-Fouch#{233}, M., 973 on guinea pig and human beta adre- Gillespie, T. J., see Brownson, E. A., 675 Ferrer, I., see Pol, 0., 386 nergic receptor subtypes: Evidence Gillis, R A., see Abrahams, T. P., 424 Fertel, R. H., see Fraundorfer, P. F., 665 for partial agonism, 665 Giovanni, A., Sieber, B.-A., Heikkila, R. E. Fetoplacental growth, chronic cocaine ef- Frazer, A., see Scott, P. A., 198 and Sonsalla, P. K.: Studies on ape- fects on, in rats, 392 Freier, D. 0. and Fuchs, B. A.: A mechanism cies sensitivity to the dopaminergic Fetus of action for morphine-induced im- neurotoxin 1-methyl-4-phenyl-1,2,3, hemodynamic responses to cocaine, co- munosuppression: Corticosterone 6-tetrahydropyridine. Part 1: Sys- caethylene and benzoylecgonine, in mediates morphine-induced suppres- temic administration, 1000 lambs, 118 sion of natural killer cell activity, Giovanni, A., Sonsalla, P. K. and Heikkila, mesencephalic graft transplantation, res- 1127 R E.: Studies on species sensitivity toration of dopamine overflow by, in Friedman, H., see Zhu, W., 1334 to the dopaminergic neurotoxin 1- rat striatum, 814 Fromenty, B., see Berson, A., 167 methyl-4-phenyul-i,2,3,6-tetrahy- Fiaugh, M. E., see Foreman, M. M., 1270 Frontal cortex, dopamine uptake in, effects dropyridine. Part 2: Central admin- Fibroblasts of chronic cocaine on, in rats, 133 istration of l-methyl-4-phenylpyri- 5-HT1B responses, in Chinese hamster Frusciante, M. J., see Javitt, D. C., 604 dinium, 1008 lung, 938 Fuchs, B. A., see Freier, D. 0., 1127 Giusti, P., see Auta, J., 1262 a42 nicotinic acetylcholine receptors in, Fujino, M., see Ikeda, S., 728 Glowa, J. R., see Rothman, R. B., 296 new agonist sites, 768 Fukami, T., see Ozaki, S., 1035 Glucocorticoids, cycbooxygenase regulation Fields, J., see Keshavarzian, A., 1057 Fuller, R. W., see Foreman, M. M., 1270 by, in peritoneal macrophages, 1340 Fisch, C., see Berson, A., 167 Furosemide, pulmonary and venous smooth Glutathione-modulating agents, effects on Fisher, D. M., see Caldwell, J. E., 1216 muscle relaxation by, comparison diquat toxicity and lipid peroxide- Fisher, M., Huangfu, D., Shen, T. Y. and with morphine, 1077 tion, in rats, 858 Guyenet, P. G.: Epibatidine, an al- Furukawa, T., see Domae, M., 55 Glycine receptors kaloid from the poison frog Epipedob- ethanol effects on, in mouse, 61 GABA, see ‘y-Aminobutyric acid ates tricolor, is a power ganglionic strychnine-insensitive, differential effects Gaginella, T. S., Mascolo, N., Izzo, A. A., depolarizing agent, 702 of compounds that act at, in punish- Autore, G. and Capasso, F.: Nitric Flemming, D., see Zacny, J. P., 579 ment procedure, 528 oxide as a mediator of bisacodyl and Fletcher, S. R., see Atack, J. R., 70 P-Glycoprotein, effects on transepitheial Flunarizine, effects in ameliorating effects phenolphthalein laxative action: In- flux of cimetidine, in MDCK cells, 1 of nefiracetam, 881 duction ofnitric oxide synthase, 1239 Glycoprotein lib/Ila antagonists, SK&F Flunitrazepam, efficacy, effects of chronic Galanthamine, a42 nicotinic acetylcholine 106760, in vivo pharmacological pro- flurazepam on, 485 receptor agonist effects, 768 ifie, 614 Flurazepam, chronic, effects on benzodiaze- Gallstones, effects of lovastatin on, in hu- Gobert, A., see Milan, M. J., 958 pine efficacy, 485 mans, 841 Goettler, J., see Perkins, K. A., 628 Fonts, C., see Perkins, K. A., 628 Ganglion neurons Goldstein, D. S., see Yadid, G., 1158 Food intake dorsal root, opioid effects on calcium Gordon J. T., Tomlinson E. E. Greenberg, DOM-induced decreases channels in, in rat, 466 J. and Dratman M. B.: An acute dose mediation by 5-HT receptors, in rats, dorsal root-neuroblastoma hybrid ND8- of desmethylimipramine inhibits 127 47 cells, opioid effects on intracellu- brain uptake of ‘933’,5-triiodothy- tolerance to, in rats, 127 lar-free calcium in, 40 ronine (T3) in thyroxine-induced but radiation-induced decreases, effects of Ganglionic nicotinic receptors, epibatidine not T3-induced hyperthyroid rats: chlordiazepoxide, 8-OH-DPAT and agonist, 702 Implications for tricydic antidepres- ondansetron on, in rats, 127 Gareau, Y., see Metters, K. M., 399 sant therapy, 111 Foreman M. M. Fuller R. W., Rasmussen Garippa, R. J., see O’Donnell, M., 1282 Goresky, C. A., see Pang, K. S., 285 K. Nelson, D. L. Calligaro D. 0., Garippa, R. J., see O’Donnell, M., 1289 Goshima, K., see Okazaki, K., 1319 Zhang L. Barrett, J. E. Booher R. N., Garvey, D. S., see Arneric, S. P., 310 Goto, S., see Higaki, K., 329 Paget C. J. Jr. and Fiaugh, M. E.: Garvey, D. S., see Decker, M. W., 319 Goz, B. and Jeffs, L.: The enhancement of Pharmacological characterization of Gastric acid, secretion, inhibition by 5-HT1- the frequency of resistance to N- LY293284: A 5-HT1A receptor agonist like receptors, in rat, 1139 phosphonoacetyl-l-aspartate and with high potency and selectivity, Gastric mucosal blood flow, beta-3 agonist methotrexate by 1-fi-d-arabinofura- 1270 enhancement of, effects on antral ul- nosylcytosine: The effect of dipyri- Forkert, P.-G., see Lee, R. P., 371 cers, in rat, 559 damole, 480 Fornal, C. A., Litto, W. J., Metzler, C. W., Gastric ulcers Gray, G. A., see Clozel, M., 228 Marrosu, F., Tada, K. and Jacobs, B. beta-3 agonist effects on, in rat, 559 Greenberg, J., see Gordon, J. T., 111 L.: Single-unit responses of seroto- effects of YM022 against, in rats, 1256 Greenberg, S., McGowan, C., Xie, J. and nergic dorsal raphe neurons to 5- Gastrin/cholecystokinin-B receptors, an- Summer, W. R.: Selective pulmonary HT agonist and antagonist drug ad- tagonist antiulcer effects, in rats, and venous smooth muscle relaxation ministration in behaving cats, 1345 1256 by furosemide: A comparison with Fornal, C. A., Marrosu, F., Metzler C. W., Gastrointestinal transit, opioid inhibition morphine, 1077 1994 Index 1405

Gregus, Z., see Oguro, T., 1145 Hepatitis, halothane, liver antigens in, 1325 substituted, pharmacodynamics of Grider, J. R, see Hellstrom, P. M., 236 Heptylphysoetigmine, cholinesterase inhib- hepatic CYP2B induction by, in rat, Grider, J. It, see Jin, J.-G., 433 itor effects, in rat, 277 348 Grobe, J. E., see Perkins, K. A., 628 Herschman, H. R., see Masferrer, J. L., 1340 Hydrophilic compounds, epithelial trans- Gros, C., see Bralet, J., 8 Herzer, W. A., see Jackson, E. K., 589 port, effects of anisotonic solutions Gruenke, L. D., see Caldwell, J. E., 1216 -y-Hexachlorocyclohexane, see Lindane on, in human, 1373 Guanylylcyclase, soluble, desensitization of, (+)-4,5,5a,6,7,8-Hexahydro-6-rnethyl-thia- Hydroxy fatty acids, n-6 and n-3, inhibitory in rat medullary interstitial cells, 761 zolo[4,5-fjquinoline-2-amine, see PD effects on thromboxane, 1105 Guengerich, F. P., see Shimada, T., 414 128483 8-Hydroxy-2-(di-n-propylamino)tetralin, Guidotti, A., see Auta, J., 1262; Romeo, E., Hidaka, H., see Okazaki, K., 1319 see 8-OH-DPAT 89 Higaki, K., Kadono, K., Goto, S. and Nak- 6-Hydroxydopamine, neonatal, effects on Gustmn, P., see Delaunois, A., 30 ano, M.: Stereoselective renal tubular monoamine metabolism, in rat, 713 Guyenet, P. G., see Fisher, M., 702 secretion of an organic anion in the 4-tert-butyl-N-[6-(2-Hydroxyethoxy)-5-(2- Gwathmey, J. K., see Liao, R, 831 isolated perfused rat kidney, 329 methoxy-phenoxy)-2,2’-bipyrimithn- Gygi, S. P., Gibb, J. W. and Hanson, G. R: Hill, J. L., see Aulakh, C. S., 127 4-ylj-benzenesulfonamide, see Boa- Differential effects of antipsychotic Hines, J., see Raynor, K., 1381 entan and psychotomimetic drugs on neu- Hippocampus 6-Hydroxylation, testosterone, P450 3A- rotensin systems of discrete extra- acetylcholine efflux, 5-HT1A receptor ef- dependent, inhibition by oxazaphos- pyramidal and limbic regions, 192 fects on, in guinea pig, 656 phorines, in human liver, 645 noradrenalin synthesis by, effects of rat 5-Hydroxytryptamine, see Serotonin Hadjiconstantinou, M., Hubble, J. P., Wem- adrenoceptors in, 958 5-Hydroxy-i-tryptophan, metabolism, ef- linger, T. A. and Neff, N. H.: En- Hirth, G., see Clozel, M., 228 fects of neonatal 6-hydroxydopamine hanced MPTP neurotoxicity after Histamine H3 receptors, signaling path- on, in rat, 713 treatment with isoflurophate or cho- ways, in guinea pig duodenum, 788 Hypertension linergic agonists, 639 Ho, A., see Unterwald, E. M., 1387 caffeine effects in, 1063 Hajj-Ali, A. F., Reilly, T. M. and Wong P. Hogarth, L., see Ujiie, K., 761 effects on NE-induced vasodilation, in C.: Modulation ofrenal vasoconstric- Honrado, C. P., see Standifer, K. M., 1246 rat, 520 tor effect of N#{176}-nitro-l-arginine in Hornby, P. J., see Abrahams, T. P., 424 gemfibrozil effects on triglyceride metab- rabbit by angiotensin II and alpha-i Hoshino, T., see Nozawa, Y., 566 olism in, in DaM salt-sensitive rats, adrenergic receptor blockade, 1152 Howell, R. E., Laemont, K. D., Kovalaky, 809 Haloperidol M. P., Lowe, V. C., Waid, P. P., Kin- Hyperthermia differential effects on neurotensin sys- nier, W. J. and Noronha-Blob, L.: m-CPP-induced, tolerance to, in rats, 127 tems, 192 Pulmonary pharmacology of a novel, DOM-induced pyridinium derivative, 1-methyl-4-phen- smooth muscle-selective muscarinic mediation by 5-HTM receptors, in rats, ylpyridinium-like neurotoxicity of, antagonist in vivo, 546 127 822 Hruby, V. J., see Brownson, E. A., 675 tolerance to, in rats, 127 Halothane-induced liver antigens, 1325 Hsu,C.-Y.,seeTune,B. M.,873 Hyperthyroidism, thyroxine-induced, des- Halpert, J. R., see Kraner, J. C., 1367 Hsu, W. H., see Chen, T.-H., 900 methylimipramine inhibition of [1IJ Halushka, P. V., see Allan, C. J., 446; Yin, 3,3’,5-T3 brain uptake in, in rats, 111 K., 1192 5-HT, see Serotonin HT-29.cll9A cells, transport of hydrophilic Hypertriglyceridemia, gemfibrozil effects Hanson, G. R, see Gyp, S. P., 192 on, in DaM salt-sensitive rats, 809 compounds across, effects of aniso- Hanson, G. R., see Johnson, M., 97 tonic solutions on, 1373 Hypertrophy Hare, C. M., see Durham, S. L, 185 cardiac, effects of alatriopril on, compar- Harrison, L M., see Zadina, J. E., 1086 5-HTP, see 5-Hydroxy-1-tryptophan Hu, X.-J. and Ticku, M. K.: Chronic flare- ison with captopril, in rats, 8 Harrison, N. L, see Zimmerman, S. A., 987 zepam treatment produces decreased cardiomyocyte Hartman, J. C., see Wall, T. M., 681 1,4-dihydropyridine binding sites in, efficacy ofthe benzodiazepine ligands Hartman, J. C., Kurc, G. M., Hullinger, T. and pentobarbital with -y-aminobu- 697 G., Wall, T. M., Sheehy, R. M. and effects ofPKC on phoephodiesterase in, tyric acid receptors in cortical neu- Shebuski, R. J.: Inhibition of nitric in hamster hearts, 1171 rons, 485 oxide synthase prevents myocardial voltage-sensitive calcium channels in, Huangfu, D., see Fisher, M., 702 protection by ramiprilat, 1071 697 Hubbard, W. C., see Fernandes, L. B., 1166 Haruno, A., see Nozawa, Y., 566 Hypophagia Hubble, J. P., see Hadjiconstantinou, M., Hasegawa, J., see Ohnishi, A., 342 DOM-induced 639 Hasegawa, T., see Yamada, K., 881 mediation by 5-HT receptors, in rats, Hughes, M. L., see Arneric, S. P., 310 Hay, D.W.P., see Underwood, D. C., 250 127 Hullinger, T. G., see Hartman, J. C., 1071 Heart, see also under Cardiac tolerance to, in rats, 127 Human calcitonin gene-related peptide-a hypertrophic cardiomyopathic, effects of radiation-induced, effects of chlordiaze- PKC on phosphodiesterase in, in receptors, cross-reactivity with rat poxide, 8-OH-DPAT and ondanse- hamster, 1171 amylin, 779 tron on, in rats, 127 Human neutrophil elastase, oral inhibitor, troponin subunits, calcium interactions Hypotension, hemorrhagic, role of adeno- between, effects of MCI-154 and cal- 185 sine in, 589 feine on, in bovine, 831 Human peripheral blood monocyte throm- Hypothalamo-pituitary-adrenocortical axis Heart failure, effects of alatriopril on, corn- boxane A2 receptors, characterization 5-HT agonist effects on, 905 parison with captopril, in rats, 8 of, 446 5-HT2 agonist effects on, 918 Human SHSY5Y neuroblastoma cells Heikkila, R. E., see Giovanni, A., 1000 Hypothermia, 5-HT1A, 541T1A agonist ef- Heikkila, R. E., see Giovanni, A., 1008 differential regulation of mu and delta fects on, 198 Hellstrom, P. M., Murthy, K. S., Grider, J. opioid receptors in, 1086 R and Makhlouf, G. M.: Coexistence opioid desensitization in, 177 Ibuprofen-associated nephrotoxicity, in ofthree tachykinin receptors coupled Human ventricular myocardium, angioten- renal dysfunction, 1307 to Ca signaling pathways in intes- sin II receptor subtypes, 566 Ifosfamide, inhibition of P450 3A by, in tinal muscle cells, 236 Humans human liver, 645 H#{233}luy,V., see Breuiller-Fouch#{234}, M., 973 ethnic differences in erythrocyte COMT Ihara, M., see Ozaki, S., 1035 Hemoperfusion, avidin-biotin system, in activity, 26 Ikeda, S., Awane, Y., Kusumoto, K., Waki- rats, 356 interindividual P450 variations, 414 masu, M., Watanabe, T. and Fujino Hemorrhagic hypotension, role of adenosine Hutson, P. H., see Wilkinson, L. 0., 656 M.: A new endothelin receptor antag- in, 589 Hydantoins, 5,5-diphenyl- and 5,5-diethyl- onist, TAK-044 shows long-lasting 1406 Index Vol. 270

inhibition of both ETA- and ETB- ethanol effects on, in mouse, 61 Kenna, J. G., see Knight, T. L., 1325 mediated blood pressure responses in glycine-activated, ethanol effects on, in Keshavarzian A. Zorub 0., Sayeed M. Ur- rats 728 mouse, 61 ban, G. Sweeney C., Winship D. and llama longitudinal muscle myenteric plexus, 1P3, see Inositol 1,4,5-trisphosphate Fields J.: Acute ethanol inhibits cal- contraction, by cholecystokinin A Ipsapirone, unit responses to, in behaving cium influxes into esophageal smooth receptor, in guinea pig, 734 cats, 1345 but not striated muscle: A possible Ileus, peritoneal-irritation-induced, fedoto- Isaac, L., see Ristic, H., 534 mechanism for ethanol-induced in- zine reversal of, in rats, 846 Ishikawa, K., see Ozaki, S., 1035 hibition of esophageal contractility, Imidazenil, tolerance and dependence liabil- Ishikawa, T., see Okazaki, K., 1319 1057 ities, in rat, 1262 Isoflurophate, effects on MPTP neurotox- Khan, I. M., Taylor, P. and Yaksh, T. L: Imidazoline receptors, mediation of rilmen- icity, 639 Cardiovascular and behavioral re- idine sympathoinhibition by, 572 F2-Isoprostanes, in diquat toxicity, in rats, sponses to nicotinic agents adminis- Immunoeuppreseion, morphine-induced, 858 tered intrathecally, 150 mediation by corticosterone, 1127 i-[N,0-bis(5-Isoquinolinesulfonyl)-N- Khan, I. M., Yaksh, T. L and Taylor, P.: Inabe, K., see Nozawa, Y., 566 methyl-l-tyrosyl]-4-phenylpipera- Ligand specificity of nicotinic acetyl- Inflammation, intestinal, opioid sensitize- zine, see KN-62 choline receptors in rat spinal cordi tion during, in mice, 386 Isosaki, M., Minami, N. and Nakashima, T.: Studies with nicotine and cytisine, InfLammatory mediators, EFS release, in Pharmacological evidence for regu- 159 guinea pig trachea, 1166 lation of Na-Ca exchange by Kiang, J. G., see Tang, T., 40 Inositol monophosphates, effects of L-690, Ca/calmodulin-dependent protein Kidneys, see also under Renal 488 on, 70 kinase in isolated bovine adrenal amantadine transport, in rat, 979 Inoaitol 1,3,4,5-tetrakisphoephate, effects of medullary cells, 104 cortical mitochondria, cephaloridine tox- L-690,488 on, 70 Ito, H., see Nishida, A., 1256 icity in, in rabbit, 873 Inositol triphoephate, and energy-force cou- Izu, L T., see Kim, W.-K., 336 cytochrome P4502E1 induction in, in rat, pling, in rabbit aorta, 708 Izzo, A. A., see Gaginella, T. S., 1239 407 Inositol 1,4,5-trisphosphate Jackson, E. K., see Kost, C. K., Jr., 1063 diquat toxicity, effects of selenium defi- effects of L-690,488 on, 70 Jackson, E. K., Herzer, W. A. and Kuan, C.- ciency and glutathione-modulating intracellular levels, AVP-stimulated in- J.: Role of adenosine in noradrenergic agents on, in rats, 858 crease, in rat insulinoma cells, 900 neurotransmission during hemor- dysfunction, ibuprofen-associated neph- Inositol 1,4,5-trisphosphate-sensitive cal- rhagic hypotension, 589 rotoxicity in, 1307 cium channels, release by lindane, in Jacob, R. G., see Perkins, K. A., 628 epithelial cells, 5-HT18 responses, in rat myometrial smooth muscle cells, Jacobs, B. L., see Fornal, C. A., 1345 opossum, 938 1015 Jacobs, B. L., see Fornal, C. A., 1359 hemodynamic effects of ramiprilat and Inotropic agents Janssen, Y.P.G., see Thijssen, H.H.W., 554 captopril on, 491 caffeine, in bovine hearts, 831 Janusz, M. J., see Durham, S. L, 185 Madin-Darby canine cells, P-glycoprotein MCI-154, in bovine hearts, 831 Japanese, interindividual P450 variations, effects on cimetidine transepithelial Inoue, T., see Domae, M., 55 414 flux across, 1 Insulin, secretion, AVP-stimulated increase, Javitt, D. C., Frusciante, M. J. and Zukin, porcine epithelial LLC-PK1 cells, ETB in rat insulinoma cells, 900 S. R.: Activation-related and activa- receptor subtypes in, 1035 Insulinoma cells, AVP effects in, inhibition tion-independent effects of polya- stereoselective secretion, in rat, 329 by U-73122, in rat, 900 mines on phencycidine receptor Kim, D.J.B., see Decker, M. W., 319 Interleukin-1 binding within the N-methyl-d-as- Kim, H. Y., see Karanian, J. W., 1105 effects on canine parietal cells, 440 partate receptor complex, 604 Kim, W.-K., Johnson, R. G., Izu, L T. and secretion, enhancement by THC, 1334 Jeffs, L., see Goz, B., 480 Rabin, R. A.: Chronic ethanol expo- Interleukin-1, effects on metallothionein Jim, J.-G., Katsoulis, S., Schmidt, W. E. sure inhibits ATP-stimulatedbut not induction and cytoprotection, 1313 and Grider, J. R: Inhibitory tram- KCI-stimulated dopamine release in Intestinal epitheial cells, cephalosporin mission in tenia coil mediated by dis- PC 12 cells, 336 transport in, in human, 498 tinct vasoactive intestinal peptide Kimura, K., see Bboomquist, J., 822 Intestinal inflammation, opioid sensitize- and apamin-sensitive pituitary aden- Kimura, R., see Nozawa, Y., 566 tion during, in mice, 386 ylate cyclase activating peptide King, E., see Bboomquist, J., 822 Intestinal muscle cells, tachykinin receptors receptors, 433 Kinnier, W. J., see Howell, R. E., 546 on, 236 Johnson, M., Sonsalla, P. K., Letter, A. A., Kiyosue, T., see Cheng, Y.-N., 851 Intracellular calcium Hanson, G. R. and Gibb, J. W.: Role Klaassen, C. D., see Oguro, T., 1145 AVP-stiniulated increase, in rat insulin- of the 5-HT2 receptor in the meth- Klein, T. W., see Zhu, W., 1334 oma cells, 900 amphetamine-induced neurochemi- Klopp, A. J., see Brenner, G. M., MO effects of opioid delta receptors on, in cal alterations, 97 KN-62, myocardiac effects, in fetal mouse, ND8-47 cells, 40 Johnson, R G., see Kim, W.-K., 336 1319 lindane effects on, in rat myometrial Jones, M. W., see Zimmerman, S. A., 987 Knickle, L C., Philpot, R. M. and Bend, J. smooth muscle cells, 1015 Junien, J.-L, see Rivi#{233}re,P.J.M., 846 R.: N-Aralkylated derivatives of 1- x0 effects on, in vascular endothelial Kadono, K., see Higaki, K., 329 aminobenzotriazole are potent iso- cells, 1197 Kalant, H., see Wu, P. H., 802 zyme- andlung-selective mechanism- Intracellular calcium blockers, KT-362, 851 Kalina, B., see Clozel, M., 228 based inhibitors of guinea pig cyto- Intrapulmonary arteries, muscarirnc recap- Kamato, T., see Nishida, A., 1256 chrome P.450 in viuo, 377 tore, pharmacological characteriza- Kang, C. J., see Decker, M. W., 319 Knight, T. L, Scatchard, K. M., Van Pelt, tion, in rabbit, 269 Karanian, J. W., Kim, H. Y. and Salem, N., F.N.A.M. and Kenna, J. G.: Sara him, K.-!., see Matsumoto, 5.-I., 498 Jr.: Inhibitory effects of n-6 and n-3 from patients with halothane hepa- him, M., see Okazaki, K., 1319 hydroxy fatty acids on thromboxane titis contain antibodies to halothane- him, Y., see Shimada, T., 414 (U46619)-induced smooth muscle induced liver antigens which are not 3$-[4’-Iodophenyljtropan-2fi-carboxylic contraction, 1105 detectable by immunoblotting, 1325 acid methyl ester, see RTI-55 Kastin, A. J., see Zadina, J. E., 1086 Kobayashi, A., see Nishida, A., 1256 Ion currents Katsoulis, S., see Jin, J.-G., 433 Kobayashi, S., see Lepor, H., 722 cardiac, effects of KT-362 on, in guinea Katz, J. L., see Terry, P., 1041 Kodama, H., see Kuratani, K., 559 pig, 851 Keith, L. D., see Roberts, A. J., 505 Koehl, J. It, see Durham, S. L, 185 GABAA-activated Kelly, K. L., see Bushnell, P. J., 15 Kokate, T. G., Svensson, B. E. and Rn- anesthetic potency and, 987 Kelly, M. L., see Mellon, N. K., 1110 gawski, M. A.: Antioonvulsant activ- 1994 Index 1407

ity of neurosteroids: Correlation with through a 5-hydroxytryptamine1-like H. Detweiler D. J. and Eisenach, J. 7-aminobutyric acid-evoked chloride receptor in the rat, 1139 C.: Spinal cholinergic alpha-2 adre- current potentiation, 1223 Lepor, H., Zhang, W. Kobayashi, S. Tang nergic interactions in analgesia and Kondo, Y., Kuo, S.-M. and Laze, J. S.: In- R, Wang B. and ShapirO E.: A corn- hemodynamic control: Role of mus- terleukin-ifl-mediated metallothi- parison ofthe binding and functional carinic receptor subtypes and nitric onein induction and cytoprotection properties of alpha-i adrenoceptors oxide, 1301 against cadmium and cis-diarnrnine- and area density of smooth muscle in Lovastatin, effects on biliary lipids, in hu- dichloroplatinum, 1313 the human, canine and rat prostates, mans, 841 Kong, G., see Raynor, K., 1381 722 Lowe, V. C., see Howell, R. E., 546 Kong, H., see Raynor, K., 1381 Letter, A. A., see Johnson, M., 97 Lubet, R. A., see Nims, R W., 348 Koob, G. F., see Caine, S. B., 209 Leukotriene C4, binding sites in sheep lung, Lubic, S. P., GiacOmini, K. M. and Giacom- Kopin, L J., see Yadid, G., 1158 399 ini,J. C.: Increased 1,4-dihydropyri- Kost, C. K., Jr., Li, P., Pfeifer, C. A. and Leukotriene D4, binding sites in sheep lung, dine binding sites in serum-stimu- Jackson, E. K.: Telemetric blood 399 lated cardiomyocyte hypertrophy, pressure monitoring in benign 2-kid- Leukotriene receptors, in sheep lung, 399 697 ney, 1-clip renovascular hyperten- Li, P., see Kost, C. K., Jr., 1063; Lothe, A., Lucchesi, B. R, see Black, S. C., 1208 sion: Effect ofchronic caffeine inges- 1301 Lungs, see also under Pulmonary tion, 1063 Liao, R and Gwathmey, J. K.: Effects of ACE rate constants in vivo, 260 Koster, P. F., see Nichols, A. J., 614 MCI-1M and caffeine on Ca-regu- CGRP effects on pulmonary edema, in Kotzer, C. J., see Underwood, D. C., 250 lated interactions between troponin rabbit, 30 Kovaisky, M. P., see Howell, B.. E., 546 subunits from bovine heart, 831 CYP45O 2Bx inactivation, in guinea pig, Kraner, J. C., Morgan, E. T. and Halpert, Lichtor, J. L., see Zacny, J. P., 579 377 J. R.: Selective suppression of rat he- Lin, S. Z., see Want, Y., 814 eosinophil influx, PDE inhibitor effects patic cytochrome P450 2C11 by Lindane, effects on myometrial calcium, in on, in guinea pigs, 250 chloramphenicol, 1367 rat, 1015 fibroblast 5HT1B responses, in Chinese Kreek, M. J., see Unterwald, E. M., 1387 Lindstrom, J., see Pereira, E.F.R, 768 hamster, 938 KT-362, effects on cardiac ion currents, in Lipid peroxidation, effects of selenium de- leukotriene receptors in, in sheep, 399 guinea pig, 851 ficiency and glutathione-modulating relaxation by furosemide, comparison Kuan, C.-J., see Jackson, E. K., 589 agents on, in rats, 858 with morphine, 1077 Kuehnle, J. C., see Teoh, S. K., 1134 Lipoproteins, effects oflovastatin on, in hu- vascular muscarinic receptors, in rabbit, Kume, A., see Sakurai, S. Y., 362 mans, 841 269 Kuo, S.-M., see Kondo, Y., 1313 Lithium, effects on phosphatidylinositol Luo, X., see McLeod, H. L, 26 Kuratani, K., Kodama, H. and Yamaguchi, cycle, 70 Luttmann, M. A., see Underwood, D. C., 250 I.: Enhancement of gastric mucosal Litto, W. J., see Fornal, C. A., 1345 Luzardo, 0. P., see Fern#{225}ndez, L, 1121 blood flow by beta-3 adrenergic ago- Liu, J. C., see Want, Y., 814 LY293284, pharmacological characterize- nists prevents indomethacin-induced Liu, J.-F., see Wu, P. H., 802 tion, 1270 antral ulcer in the rat, Liu, L, see Oguro, T., 1145 559 Macrophages Kurc, G. M., see Hartman, J. C., 1071 Liver peritoneal, cycbooxygenase regulation by Kus, T., see Derakhchan, K., 47 antigens, halothane-induced, 1325 glucocorticoids in, 1340 Kusumoto, K., see Ikeda, S., 728 CYP2B induction pharmacodynamics, in rat, 348 THC enhancement of ILl secretion in, L-690,33O, effects on phosphatidylinositol CYP2C11 suppression by chlorampheni- 1334 cycle, 70 col, in rat, 1367 Madhu, C., see Oguro, T., 1145 L-690,488, effects on phosphatidylinositol CYP2E1 biotransformation of DCE in, in Madin-Darby canine kidney cells, cimeti- cycle, 70 mice, 371 dine transepithellal flux across, ef- Lacreta, F. P., Brennan, J. M., Nash, S. L, CYP3A inhibition by oxazaphosphorines, fects of P-glycoprotein on, 1 Comis, R. L, Tew, K. D. and in human, 645 Maelicke, A., see Pereira, E.F.R, 768 O’Dwyer, P. J.: Pharmacokinetics dexamethasone bindingsites in, induction Makhlouf, G. M., see Hellstrom, P. M., 236 and bioavailability study of ethac- by ethinylestradiol, in male rat liver, Maldonado, R., see Valverde, 0., 77 rynic acid as a modulator of drug 1121 Manchand, P. 5., see Nims, R. W., 348 resistance in patients with cancer, diquat toxicity, effects of selenium defi- Manganese-based superoxide dismutase mi- 1186 ciency and glutathione-modulating metic, reduction of infarct size by, Laemont, K. D., see Howell, It E., 546 agents on, in rats, 858 1208 Lambert, C., see Derakhchan, K., 47 interindividual P450 variations, in hu- Marie, C., see Bralet, J., 8 Lanca, A. J., see Wu, P. H., 802 man, 414 Maria, J., see Arribas, S., 520 Law, P. Y., see Prather, P. L, 177 PAPS depletion by molybdate in, in rats, Marquart, A. L, see Durham, S. L., 185 Laxatives, mediation by nitric oxide, 1239 1145 Marrosu, F., see Fornal, C. A., 1345 Laze, J. S., see Kondo, Y., 1313 salicylamide uptake, multiple indicator Marrosu, F., see Fornal, C. A., 1359 L-DOPA, see 3,4-Dthydroxyphenylalanine dilution study, in rat, 285 Martin, B. R., see Smith, P. B., 219 Le Marouille-Girardon, S., see Milan, M. Liver microsomes, ethinylestradiol interac- Martin, P. L and Potts, A. A.: The ends- J., 958 tion with, in male rat, 1121 thelium of the rat renal artery plays Lecomte, J.-M., see Bralet, J., 8 LLC-PK1 cells, ETB ptor subt3Tf)5 in, an obligatory role in A2 adenosine Lee, B., see Chen, T.-H., 900 1035 receptor-mediated relaxation in- Lee, H.-C., Cal, J. J. and Yu, H.: Effect of Uuch, S., see Martinez, M. C., 622 duced by 5’-N-ethylcarboxamidoad- protein kinase C on cyclic 3’,5’-aden- Loch-Caruso, R., see Criswell, K. A., 1015 enosine and N’-cyclopentyladeno- osine monophosphate-dependent Locomotion sine, 893 phoephodiesterase in hypertrophic cocaine effects on, in inbred mice, 1230 Martinez, M. C., Aldasoro, M, VHs, J. M., cardiomyopathic hamster hearts, nucleus accumbens amphetamine effects Medina, P. and iluch, S.: Responses 1171 on, sensitization by ventral tegmen- to vasopressin and desmopressin of Lee, K P. and Forkert, P.-G.: In vitro bio- tel area amphetamine, 690 human cerebral arteries, 622 transformation of 1,i-dichloroethyl- Loffler, B.-M., see Clozel, M., 228 Mascolo, N., see Gaginella, T. S., 1239 ene by hepatic cytochrome P-450 2E1 Lord, A., see Metters, K. M., 399 Masferrer, J. L, Reddy, S. T., Zweifel, B. in mice, 371 Losartan, binding sites in bovine and hu- S., Seibert, K., Needlernan P., Gilbert LePard, K. J. and Stephens, R. L, Jr.: Se- man ventricular myocardium, 566 R. S. and Herechman H. R.: In vioo rotonin inhibits gastric acid secretion Lothe, A. Li, P. Tong C., Yoon Y. Bouaziz, glucocorticoids regulate cycbooxygen- 1408 Index Vol. 270

ase-2 but not cycbooxygenase-1 in differential effects on neurotensin sys- dowson P., Renouard A. Le Mar- peritoneal macrophages, 1340 tems, 192 ouille-Girardon, S. and Gobert A.: Masserano, J. M., Venable, D. and Wyatt, neurochemical effects, role of 5-HT2 Multiple alpha-2 adrenergic receptor R J.: Effects of chronic cocaine ad- receptors in, 97 subtypes. II. Evidence for a role of ministration on [3H]dopamine up- neurotoxicity rat RA,IIOZA adrenergic receptors in take in the nucleus accumbens, stria- in C57BL/6J mouse, 741 the control of nociception, motor be- turn and frontal cortex of rats, 133 temperature effects on, in C57BL/6J havior and hippocampal synthesis of Matsumoto, H., Baron, C. B. and Coburn, mouse, 752 noradrenaline, 958 R. F.: Inositol triphosphate and en- Methotrexate, resistance to, effect of dipyr- Miller, D. B., see O’Callaghan, J. P., 741 ergy-force coupling in rabbit aorta, idamole on, 480 Miller, D. B. and O’Callaghan, J. P.: Envi- 708 (+)4-[n-5-(Methoxychroman-3-yl)n-pro- ronment-, drug- and stress-induced Matsumoto, 5.-I., Saito, H. and Inui, K.-!.: pylaminojbutyl-8-azaspiro[4,5]de- alterations in body temperature a!- Transcellular transport of oral ceph- cane-7,adione, see 5-20499 fect the neurotoxicity of substituted alosporins in human intestinal api- 5-Methoxy-N,N-dimethyltryptamine, unit amphetamines in the C57BL/6J thelial cells, Caco-2: Interaction with responses to, in behaving cats, 1345 mouse, 752 dipeptide transport systems in apical i-[6-[[17fi-Methoxyestra-i,3,5(iO)-trien- Miller, D. D., see Fraundorfer, P. F., 665 and basolateral membranes, 498 i7-ylaminoJhexyl]-iH-pyrrole-2,5- Miller, R. D., see Caldwell, J. E., 1216 Matsuura, N., see Nozawa, Y., 566 dione, see U-73122 Miller-Stein, C., see Nichols, A. J., 614 Mazzola-Pomietto, P., see Aulakh, C. S., 127 1-(2-Methoxyphenyl)-4-[4-(2-phthalim- Mimura, M., see Shimada, T., 414 McClain, R. M., see Nims, R. W., 348 ido)butyl]piperazine, see NAN-190 Minami, N., see Isosaki, M., 104 McGowan, C., see Greenberg, S., 1077 1-(2-Methoxyphenyl)-4-[4-(2-phthallm- Mineralocorticoid receptors, mediation of MCI-154, effects on Ca interactions be- ido)butyl]piperazine HEr, see NAN- effects of corticosterone on convul- tween troponin subunits from bovine 190 sions by, in mice, 505 hearts, 831 8-[2-[4-(2-Methoxyphenyl)-i-piperazinyl) Miosis, butorphanol, comparison with mor- McKernan, R., see Atack, J. R., 70 ethyl]-8-azaspiro[4,5]decane-7,9- phine, in healthy volunteers, 579 McLeod, H. L, Fang, L, Luo, X., Scott, E. dione, see BMY 7378 Mitochondria, renal cortical, cephaloridine P. and Evans, W. E.: Ethnic differ- N-Methyl-d-aspartate receptors toxicity in, in rabbit, 873 ences in erythrocyte catechol-O- activation of, spermidine effects on, 604 Mitochondrial diazepam-binding inhibitor methyltransfease activity in black antagonist differential effects, in punish- receptor complex, agonist effects on and white Americans, 26 meat procedure, 528 dizocilpine amnesia, 89 McLoughlin, C., see Caldwell, J. E., 1216 6-Methylene naltrexone, behavioral effects, Mitochondrial respiratory chain, effects of MDA, see Methylenedioxyamphetamine in rhesus monkeys, 992 nilutamide on, in rats, 167 MDCK cells, see Madin-Darby canine kid- Methylenedioxyamphetamine, neurotoxic- Miyamoto, Y., Bowen, W. D., Portoghese, ney cells ity P. 5. and Takemori, A. E.: Lack of MDL 72,222, see Bemesetron in C57BL/6J mouse, 741 involvement of delta-i opioid recep- MDL 73005, effects on acetylcholine efflux, temperature effects on, in C57BL/6J tore in the development of physical in guinea pig, 656 mouse, 752 dependence on morphine in mice, 37 MDL 101,146, pharmacology of, 185 Methylenedioxymethamphetamine, neuro- Miyata, K., see Nishida, A., 1256 MDMA, see Methylenedioxymethamphe- toxicity Molina-Holgado, E., Dewar, K. M., Descar- tamine in C57BL/6J mouse, 741 ries, L and Reader, T. A.: Altered MDRC, see Mitochondrial diazepam-bind- temperature effects on, in C57BL/6J dopamine and serotonin metabolism ing inhibitor receptor complex mouse, 752 in the dopamine-denervated and se- Mechoulam, R., see Smith, P. B., 219 (S)-3-Methyl-5-(1-methyl-2-pyrrolidi- rotonin-hyperinnervated neostria- Medina, P., see Martinez, M. C., 622 nyl)isoxazole, see ABT 418 tam of adult rat after neonatal 6- Medrano, T., see Salhab, A. S., 392 1-Methyl-4-phenylpyridinium, neurotoxic- hydroxydopamine, 713 Medullary cells, adrenal, Ca/calmodulin- ity, species sensitivity, 1000, 1008 Molybdate, PAPS depletion by, in rats, 1145 dependent protein kinase regulation 1-Methyl-4-phenylpyridinium-like neuro- Monoamines, metabolism, effects of neo- of Na-Ca exchange in, in bovine, toxicity, of haloperidol pyridinium natal 6-hydroxydopamine on, in rat, 104 derivative, 822 713 Medullary interstitial cells, desensitization 1-Methyl-4-phenyl-i,2,3,6-tetrahydropyri- Monocyte thromboxane A2 receptors, char- of soluble guanylyl cyclase in, in rat, dine, neurotoxicity acterization of, in human peripheral 761 effects of cholinergic drugs on, 639 blood, 446 Mehdi, S., see Durham, S. L., 185 species sensitivity, 1000, 1008 Mood, butorphanol effects on, comparison Mele, P. C., see Winsauer, P. J., 142 4-Methylpyrazole, induction of cytochrome with morphine, in healthy volun- Mellini, D. W., see Nims, R W., 348 P4502E1 in kidney by, in rat, 407 tears, 579 Mello, N. K., see Teoh, S. K., 1134 1-[2-(6-Methyl-2-pyridyl)ethylj-4-(4-meth- Morgan, E. T., see Kraner, J. C., 1367 Mello, N. K., Mendelson, J. H., Drieze, J. ylsulfonyl-aminobenzoyl)piperidine, Morphine M., Teoh, S. K., Kelly, M. L. and see E-4031 dependence on, delta-i opioid receptors Sholar, J. W.: Effects ofdopamine on a-Methylserotonin, effects in ethanol tol- in, in mice, 37 prolactin: Interactions with cocaine erance, 802 immunosuppression by, mechanism of ac- self-administration by female rhesus Metters, K. M., Gareau, Y., Lord, A., Roch- tion, 1127 monkeys, 1110 ette, C. and Sawyer, N.: Character- pulmonary and venous smooth muscle re- M#{233}nard,D. P., see van Rossum, D., 779 ization of specific binding sites for laxation by, comparison with furose- Mendelson, J. H., see Mellon, N. K., 1110 cysteinyl leukotrienes in sheep lung, mide, 1077 Mendelson, J. H., see Teoh, S. K., 1134 399 regulation of mu and delta opioid recep- Mesencephalic grafts, fetal, restoration of Metzler, C. W., see Fornal, C. A., 1345 tore by, in SH-SY5Y human neuro- dopamine overflow by, in rat stria- Metzler, C. W., see Fornal, C. A., 1359 blastoma cells, 1086 turn, 814 Microsomes, liver, ethinylestradiol interac- subjective, psychomotor and physiological Messori, E., see Ciccocioppo, R., 929 tion with, in male rat, 1121 effects, comparison with butor- Metallothionein, induction and cytoprotec- Middle cerebral arteries, nicotine relaxation phanol, in healthy volunteers, 579 tive effects, IL-lfi effects on, 1313 of, in cat, 795 suppression of natural killer cells by, me- Metergoline, mediation of DOM effects by, Middlerniss, D. N., see Wilkinson, L 0., 656 diation by corticosterone, 1127 in rats, 127 Mihara, M., see Ohnishi, A., 342 N-[4-(4-Morpholinylcarbonyl)benzoyl]-l- METH, see Methamphetamine Millan, M. J., see Renouard, A., 946 prolinamide, see MDL 101,146 Methamphetamine Millan M. J., Bervoets K. Rivet, J.-M. Wid- Mossiat, C., see Bralet, J., 8 1994 Index 1409

Motor behavior, effects of rat adre- effects on acetylcholine efflux, in guinea species sensitivity, 1000, 1008 noceptore in, 958 pig, 656 Neurotransmission, noradrenergic, during Motor toxicity, neurosteroid, 1223 effects on serotonergic unit activity, in hemorrhagic hypotension, role of MP’FP, see i-Methyl-4-phenyl-i,2,3,6-tet- behaving cats, 1359 adenosine in, 589 rahydropyridine NANC, see Nonadrenergic, noncholinergic Neurotransmitters, cerebral cortex, cholin- MUller, M., see Clozel, M., 228 relaxation esterase inhibitor effects on, in rat, Multiple indicator dilution study, of hepatic Narahashi, T., see Nomura, K., 466 277 uptake of salicylamide, in rat, 285 Narahashi, T., see Tatebayashi, H., 595 Neutrophils, metabolism of vesnarinone by, Murphy, D. L., see Aulakh, C. S., 127 NArg, see N#{176}-Nitro-l-arginine 865 Murray, M., Butler, A. M. and Stupans, I.: Nash, S. L, see Lacreta, F. P., 1186 Newton, C., see Zhu, W., 1334 Competitive inhibition of human Natural killer cells, morphine-suppressed Nichols, A. J., Vasko, J. A. Koster, P. F. liver microsomal cytochrome P450 activity, mediation by corticosterone, Valocik R. E., Rhodes G. It Miller- 3A-dependent steroid 6fi-hydroxyl- 1127 Stein, C. Boppana V. and Samanen, ation activity by cycbophosphamide ND8-.47 cells, effects of opioid delta recep- J. M.: The in vivo pharmacological and ifosfamide in vitro, 645 tore on intracellular-free calcium in, profile of the novel glycoprotein Uhf Murthy, K. S., see Hellstrom, P. M., 236 40 lila antagonist SK&F 106760, 614 Muacarinic receptors NECA, see 5’-N-Ethylcarboxamidoadeno- Nicotine effects on MP’FP neurotoxicity, 639 sine arterial relaxation by, in cat middle care- lung vascular, pharmacological character- Needleman, P., see Masferrer, J. L., 1340 bral arteries, 795 ization, in rabbit, 269 Neff, N. H., see Hadjiconstantinou, M., 639 chronic and acute tolerance to, in hu- M2, spinal, 1301 Nefiracetam, ameliorating effects, effects of mans, 628 smooth muscle-selective antagonists, voltage-sensitive calcium channels intrathecal, cardiovascular and behav- new, 546 in,881 ioral effects, 150 Muscle, see also Smooth muscle Negus, S. S., Butelman, E. R, Chang, K.-J., isoxazole analog ABT 418, 310, 319 circular, NANC relaxation of, nitric oxide DeCosta, B., Winger, G. and Woods, ligand specificity, in rat spinal cord, 159 mechanisms in, in rabbit distal colon, J. H.: Behavioral effects of the sys- Nicotinic receptors temically active delta opioid agonist 929 a42 subtype, new agonist sites, 768 human papillary, action potential dare- BW373U86 in rhesus monkeys, 1025 effects on MPTP neurotoxicity, 639 Neidhart, W., see Cbozel, M., 228 tion of, effects of class ifi drugs on, epibatidine agonist, 702 460 Nelson, D. L., see Foreman, M. M., 1270 intrathecal administration, cardiovascu- Nelson, J. A., see Pan, B.-F., 1 ileum, cholecystokinin A receptor con- bar and behavioral effects, 150 traction, in guinea pig, 734 Neomycin, effects in ameliorating effects of ligands nefiracetam, 881 Muscle cells, intestinal, tachykinin recep- ABT418, 310, 319 Neonates, 6-hydroxydopamine lesions in, tore on, 236 specificity, in rat spinal cord, 159 effects on monoamine metabolism, in Mydriasis, NPC-14695, 546 Nifedipine, effects in ameliorating effects of rat, 713 Myocardial infarction nefiracetam, 881 Neostigmine, spinal clonidine interactions, effects of alatriopril on, comparison with Nigroatriatal systems, MPP neurotoxicity, 1301 captopril, in rats, 8 species sensitivity, 1008 Neostriatum effects oframiprilaton, role ofnitric oxide NIH 10365, see Nalmefene monoamine metabolism, effects of neo- synthase in, 1071 Nilutamide, effects on mitochondriab respi- natal 6-hydroxydopamine on, in rat, reduction by superoxide dismutase mi- ratory chain, in rats, 167 713 metic, 1208 Nims R. W. McClain R. M., Manchand P. MPP neurotoxicity, species sensitivity, Myocardial preconditioning, role of brady- S. Relics, P. 5. Thomas P. E., Mellini 1008 kininin,681 D. W. Utermahlen, W. E. Jr. and Nephrotoxicity, ibuprofen-associated, in Myocardium Lubet It A.: Comparative pharma- reperfusion injury, inhibition by super- renal dysfunction, 1307 Neuroblastoma cells codynamics of hepatic cytochrome oxide dismutase mimetic, 1208 P450 2B induction by 5,5-diphenyl- BE(2)-C, opioid receptors in, 1246 ventricular, angiotensin H receptor sub- and 55-diethyl-substituted barbitu- types, in bovine and human, 566 SHSY5Y differential regulation of mu and delta rates and hydantoins in the male Myocytes, ventricular F344iNGrrat, 348 KN-62 effects on, in fetal mouse, 1319 opioid receptors in, 1086 opioid desensitization in, 177 Nishida A. Takinami, Y. Yuki H., Koba- KT-362 effects on ion currents in, in yashi A. Akuzawa, S. Kamato T., Ito guinea pig, 851 Neurokinin-1 receptors, in guinea pig bron- chus, 1295 H. Yamano, M. Nagakura Y. and Mi- Myometrium yata, K.: YMO22 a potent and selec- endothelin receptors in, in human, 973 Neurokiin-2 receptors, in guinea pig bron- chus, 1295 tive gastrincholecystokinin-B recep- lindane effects on calcium in, in rat tor antagonist prevents gastric and smooth muscle cells, 1015 Neurokinin receptors, on intestinal muscle cells, 236 duodenal lesions in rat, 1256 Mytilineou, C., see Bboomquist, J., 822 Neurosteroids Nitric oxide Nabeshiina, T., see Yamada, K., 881 antagonist effects on dizocilpine amnesia, mechanisms in peristalsis and accommo- Nagakura, Y., see Nishida, A., 1256 89 dation in rabbit distal colon, 929 Nakano, M., see Higaki, K., 329 anticonvulsant effects, 1223 mediation of laxative action by, 1239 Nakashiina, M., see Uematsu, T., 453 Neurotensin systems, differential effects of release, A2 adenosine receptor-mediated, Nakashiina, T., see Isosaki, M., 104 antipsychotic and psychotomimetic in rat renal artery, 893 Nakayama, S., see Yamada, K., 881 drugs on, 192 synthesis, role in interinediolateral cell Nalmefene, behavioral effects, in rhesus Neurotoxicity column, 1301 monkeys, 992 amphetamine Nitric oxide receptors, guanylyl cyclase- Naloxone, effects on morphine-suppressed in C57BL/6J mouse, 741 linked, desensitization of, in rat med- natural killer cell activity, 1127 temperature effects on, in C57BL/6J uliary interstitial cells, 761 Naltrexone mouse, 752 Nitric oxide synthase effects on morphine-suppressed natural 1-methyl-4-phenylpyridinium-like, of effects in ramiprilat myocardial protec- killer cell activity, 1127 haloperidol pyridinium derivative, tion, 1071 6-methylene derivative, behavioral ef- 822 induction of, 1239 facts, in rhesus monkeys, 992 MPTP N#{176}-Nitro-l-arginine, renal vasoconstrictor NAN-190 effects of cholinergic drugs on, 639 effect, in rabbit, 1152 1410 nex Vol. 270

Nitrobenzylthioinosine, effect on drug re- Oguro, T., Gregus, Z., Madhu, C., Liu, L. Oral bronchodilatore, NPC-14695, 546 sistance, 480 and Klaassen, C. D.: Molybdate de- Oral cephalosporins, transport in Caco-2 NMDA receptors, see N-Methyl-d-aspartate pletes hepatic 3-phosphoadenosine 5- cells, 498 receptors phosphosulfate and impairs the sub- Oral elastase inhibitor, pharmacology of, Noach, A.B.J., Sakai, M., Bbom-Roosema- fation ofacataminophen in rats, 1145 185 len, M.C.M., de Jonge H. R. de Boar, O’Halloran, K. P., see Winsauer, P. J., 142 Oral endothelin receptor antagonists, new, A. G. and Breimer D. D.: Effect of 8-OH-DPAT 228 anisotonic conditions on the trans. effects on acetylcholine efflux, in guinea ORG 7268, see 3-Desacetylvecuronium port ofhydrophilic model compounds pig, 656 Organic anions, stereoselective renal secre- across monolayers of human cobonic effects on adrenocortical secretion, 905 tion, in rat, 329 call lines, 1373 effects on 5-HT responses, 198 Organic cations, renal transport, in rat, 979 Nociception, effects of rat adre- effects on radiation-induced decreases in Osborn, R R., see Underwood, D. C., 250 noceptors in, 958 food intake, in rats, 142 Oxazaphosphorines, inhibition of P450 3A Nompleggi, D. J., Beinborn, M., Roy, A. and unit responses to by, in human liver, 645 Wolfe, M. M.: The effect of recom- in behaving cats, 1345 Ozaki, S., iliara, M., Saeki, T., Fukami, T., binant cytokines on 14C]-aminopy- effects of putative 5-HT antagonists Ishikawa, K. and Yano, M.: Endothe- nine accumulation by IsOlated canine on, in behaving cats, 1359 lin ET receptors couple to two dis- parietal cells, 440 Ohler, A. and Ravens, U.: Effects of E-4031, tinct signaling pathways in porcine Nomura, K., Reuveny, E. and Narahashi, almokalant and tedisaznil on postrest kidney epithelial LLC-PK1 calls, T.: Opioid inhibition and desensiti- action potential duration of human 1035 zation ofcalcium channel currents in papillary muscles, 460 rat dorsal root ganglion neurons, 466 Ohnishi, A., Mihara, M., Yasuda, S., To- Pacak, K., see Yadid, G., 1158 PACAP, see pituitary adenylate cyclase ac- Nonadrenergic, noncholinergic relaxation, mono, Y., Hasegawa, J. and Tanaka, ofcircular muscle, nitric oxide mech- T.: Aquaretic effect of the stable dy- tivating peptide Page, p., see Derakhchan, K., 47 anisms in, in rabbit distal colon, 929 norphin-A analog E2O78 in the hu- Paget, C. J., Jr., see Foreman, M. M., 1270 Noradrenalin, hippocampal synthesis, ef- man, 342 Pain modulation, see Antinociception fects of rat R,,.M adrenoceptors in, Okamoto, T., see Okazaki, K., 1319 PALA, see N-Phosphonoacatyl-l-aspartate 958 Okamura, T., see Ayajiki, K., 795 Pales, S., see Corsi, M., 734 Noradrenergic neurotranamission, during Okazaki, K., Ishikawa, T., him, M., Tada, Palmier, C., see Pauwels, P. J., 938 hemorrhagic hypotension, role of M., Goshima, K., Okamoto, T. and Pan, B.-F., Dutt, A. and Nelson, J. A.: En- adenosine in, 589 Hidaka, H.: KN-62, a specific Ca4 hanced transepithelial flux of cime- Norepinephrine calmodulin-dependentprotein kinase tidineby Madin-Darby canine kidney analgesic effects, in amphibians, MO inhibitor, reversibly depresses the cells overexpressing human P-glyco- extracellular levels, cholinesterase inhib- rate of beating of cultured fetal protein, 1 itor effects on, in rat, 277 mouse cardiac myocytes, 1319 Pancetti, F. C., see Aguayo, L. G., 61 vasodilation by, mediation by beta recap- Oliosi, B., see Corei, M., 734 Pang, 1.-H., see Ujiie, K., 761 tore, in rat, 520 O’Malley, K. L, see Tang, L., 475 Noronha-Bbob, L, see Howell, R. E., 546 Pang, K. S., Barker, F. Ill, Schwab, A. J. Ondansetron and Goresky, C. A.: Demonstration Nozawa, Y., Haruno, A., Oda, N., Yamasaki, effects on DOM effects, in rats, 127 Y., Matsuura, N., Yamada, of rapid entry and a cellular binding S., lathe, effects on radiation-induced decreases in K., Kiinura, R, Suzuki, H. and Hosh- space for salicylamide in perfused rat food intake, in rats, 142 liver: A multiple indicator dilution ino, T.: Angiotensin II receptor sub- Onori, L., see Ciccocioppo, R., 929 types human ventric- study, 285 in bovine and Opioid receptors ular rnyocardium, 566 Pang, V. F., see Chen, C.-Y., 1307 delta Papillary muscles, human, action potential NPC-14695, pulmonary pharmacology, 546 agonist behavioral effects in rhesus Nucleus accumbens duration of, effects of class ifi drugs monkeys, 1025 on, 460 amphetamine administered to, locomotor in BE(2)-C neuroblastoma cells, 1246 effects, sensitization by ventral teg- PAPS, see Adenosine 3-phosphate 5-phos- desensitization in SHSY5Y cells, 177 phosulfate mental area amphetamine, 690 differential regulation in SH-SY5Y hu- dopamine uptake in, effects of chronic Parietal cells, effects of cytokines on, in man neuroblastoma cells, 1086 cocaine on, in rats, 133 canine, 440 effects on intracellular free calcium in Partilla, J. S., see Rothrnan, R. B., 296 O’Callaghan, J. P., see Miller, D. B., 752 ND&-47 cells, 40 Pascaud, X., see Rivi#{233}re,P.J.M., 846 O’Callaghan, J. P. and Miller, D. B.: Neu- sensitization during intestinal inflam- Passive avoidance rotoxicity profiles of substituted am- mation, in mice, 386 dizocilpine effects on, neurosteroids an- phetamines in the C57BLf6J mouse, delta-i, role in morphine dependence, in tagonism of, 89 741 mice, 37 scopolamine-induced impairment of, ef- O’Connor, S. E., see Choppin, A., 650 kappa fects of calcium channels in ameio- Ode, N., see Nozawa, Y., 566 agonist reversal of ileus by, in rats, 846 rating effects of nefiracetam on, 881 O’Donnell, M., Garippa R. J. Rinaldi, N. agonist-induced diuresis, in rat, 244 Pasternak, G. W., see Standifer, K. M., 1246 Selig W. M., Simko B. Renzetti, L desensitization, 1381 Pauwels P. J. and Palmier, C.: Differential Tannu S. A., Wasserman M. A. Wel- kappa3, in BE(2)-C neuroblastoma cells, functional activity of 5-hydroxy- ton, A. and Robin D. R.: Rn 25-1553: 1246 tryptamine receptor ligands and beta A novel long-acting vasoactive intes- mu adrenergic receptor antagonists at 5- final peptide agonist Part I: In vitro analgesic effects, enhancement of, in hydroxytryptamines receptor sites and in vivo bronchodilator studies, suspended mice, 1177 in Chinese hamster lung fibroblasts 1282 in BE(2)-C neuroblastoma cells, 1246 and opossum renal epithalial cells, O’Donnell, M. Garippa It J., Rinaldi N. desensitization in SHSY5Y cells, 177 938 Selig, W. M. Tocker J. E., Tannu S. differential regulation in SH-SYSY hu- PC 12 cells, ethanol inhibition ofDA release A. Wasserman, M. A. Walton A. and man neuroblastoma cells, 1086 in, 336 Robin, D. R.: Rn 25-1553: A novel effects on calcium channel currents, in PD 123177, binding sites in bovine and hu- bong-actingvasoactive intestinal pep- rat, 466 man ventricular myocardium, 566 tide agonist Part II: Effect on in vitro sensitization during intestinal inflam- PD 128483 and in vivo models of pulmonary an- mation, in mice, 386 behavioral effects, 1049 aphylaxis, 1289 Opioids, effects on calcium channel cur- in combination with cocaine, behavioral O’Dwyer, P. J., see Lacreta, F. P., 1186 rents, in rat, 466 effects, 1049 1994 Index 1411

PDE, see Phosphodiesterase cholinesterase inhibitor effects, in rat, 277 Protein kinase C, effects on phosphodiester- Pest, N. P., see Durham, S. L, 185 Pietra, C., see Corsi, M., 734 ase, in hamster hearts, 1171 Peng, X., see Pereira, E.F.R., 768 Pituitary adenylate cyclase activating pep- Protein kinases, Cafcalmodulin-depend- Pentobarbital, efficacy, effects of chronic tide, transmission in tenia by, 433 ent flurazepam on, 485 Pituitary gland, anterior, ET-induced inhibitor myocardiac effects, in fetal Peptidases, effects on enkephalin blood cAMP accumulation in, in rat, 55 mouse, 1319 brain barrier permeability, 675 PKC, see Protein kinase C regulation of Na-Ca exchange by, in Pereira E.F.R. Ailcondon M., Reinhardt- Placenta, chronic cocaine effects on, in rats, bovine adrenal medullary calls, 104 Maelicke S. Maelicke, A. Peng X., 392 Psychomotor impairment, butorphanol ef- Lindstrom J. Whiting, P. and Albu- Platelets facts, comparison with morphine, in querque E. X.: Physostigmine and antiaggregatory effects of F-series pros- healthy volunteers, 579 galanthamine: Probes for a novel tanoids in, in humans, 1192 Psychotornimetic drugs, differential effects binding site on the a4(32 subtype of human adrenoceptore, compari- on neurotensin systems, 192 neuronal nicotinic acetylcholine son with rat RA.QZA adrenoceptors, Puig, M. M., see Pol, 0., 386 receptors stably expressed in fibro- 946 Pulmonary anaphylaxis, Rn 25-1553 effects blast calls, 768 Platinum complexes, sodium-coupled up- in, 1289 Pulmonary edema Peripheral blood monocyte thromboxane A2 take in renal proximal tubular cells receptors, characterization of, in hu- by, 1097 effects of CGRP on, in rabbit, 30 effects offurosemide on, comparison with man, 446 Plato, P. A., see Donnelly, R., 809 morphine, 1077 Peristalsis, distal colon, nitric oxide mech- Pol, 0., Ferrer, I. and Puig, M. M.: Diarrhea Pulmonary vasculature anisms in, in rabbit, 929 associated with intestinal inflamma- ACE rate constants in vivo, 260 Peritoneal macrophages, cycbooxygenase tion increases the potency of mu and CGRP effects on, in rabbit, 30 regulation by glucocorticoids in, 1340 delta opioids on the inhibition of gas- muscarinic receptors in, in rabbit, 269 Peritoneal-irritation-inducad ileus, fedoto- trointestinal transit in mice, 386 zinc reversal of, in rats, 846 relaxation by furosemide, comparison Poli, E., Pozzoli, G. and Bertaccini, G.: Sig- with morphine, 1077 Perkins, K. A., Grobe J. E. Fonte, C. Goat- nal transducing mechanisms coupled Punishment, differential effects of corn- tler J., Caggiula A. R. Reynolds, W. to histamine H3 receptors and alpha- A. Stiller R. L., Scierka A. and Jacob pounds that act at strychnine-insen- 2 adrenoceptore in the guinea pig sitive glycine receptors in, 528 R G.: Chronic and acute tolerance to duodenum: Possible involvement of subjective, behavioral and cardiovas- Pyrazole, induction ofcytochrome P4502E1 N-type Ca channels, 788 cular effects of nicotine in humans, in kidney by, in rat, 407 Polyamines, effects on phencydidine recep- Pyrethroids, tetramethrin, effects on so- 628 tor binding, 604 Peroxidation, lipid, effects of selenium de- dium channels, 595 Ponte, A., see Arribas, S., 520 ficiency and glutathione-modulating Pyridinium, haboperidol derivative, 1- Porcine kidney epitheial LLC-PK1 cells, methyl-4-phenylpyridinium-like agents on, in rats, 858 ET5 receptor subtypes in, 1035 Perugini, M. and Vezina, P.: Amphetamine neurotoxicity of, 822 Portoghese, P. S., see Miyamoto, Y., 37 administered to the ventral tegmen- 6-[4-(4-Pyridyl)aminophenyl]-4,5-dihydro- Potassium chloride, stimulation of dopa- tab area sensitizes rats to the leo- 3(2H)-pyridazinone hydrochloride, mine release by, ethanol inhibition motor effects of nucleus accumbens see MCI-1M of, 336 amphetamine, 690 Quantitative autoradiography, of [3H] Potts, A. A., see Martin, P. L, 893 Pessayre, D., see Berson, A., 167 ThOB binding, 362 Pozzoli, G., see Poli, E., 788 Petrone, G., see Wang, Y.-X., 244 Quirion, R., see van Rossum, D., 779 Prather, P. L., Teal, A. W. and Law, P. Y.: Pfeifer, C. A., see Kost, C. K., Jr., 1063 Quirk, K., see Atack, J. R., 70 Mu and delta opioid receptor desen- Phencycidine receptors, binding, polya- sitization in undifferentiated human Rabin, R. A., see Kim, W.-K., 336 mines effects on, 604 neuroblastoma SHSY5Y cells, 177 Raclopride, effects on cocaine self-adminis- Phenolphthalein, mediation by nitric oxide, Preconditioning, myocardial, role of brady- tration, in rat, 209 1239 kinin in, 681 Radek, R. J., see Decker, M. W., 319 Phenytoin, pharmacodynamics of hepatic Pregnancy, chronic cocaine effects on pla- Radial maze test, neurosteroid antagonism CYP2B induction by, in rat, 348 centa in, in rats, 392 of dizocilpine effects, 89 Philpot, R. M., see Knickle, L. C., 377 Radiation, effects on food intake, effects of Phosphatidylinositol cycle, effects of L-690, Prior, A. M., see Atack, J. R., 70 Procainamide, effects on atrial excitable chlordiazepoxide, 8-OH-DPAT and 488 on, 70 ondansetron on, in rats, 127 Phosphodiesterase, effects of PKC on, in gap, in canine, 47 Prolactin, dopamine effects on, interactions Ragan, C. I., see Atack, J. R., 70 hamster hearts, 1171 with cocaine self-administration, in Ramiprilat Phosphodiesterase III inhibitors, airway ef- myocardial female rhesus monkeys, 1110 protection by, effects of nitric facts, in guinea pigs, 250 oxide synthase in, 1071 Propafenone, effects on atrial excitable gap, Phosphodiesterase IIIfIV inhibitors, airway renal hemodynamic effects, comparison in canine, 47 effects, in guinea pigs, 250 with captopril, 491 Propranolol Phosphodiesterase IV inhibitors, airway ef- Remus, H., see Cbosel, M., 228 effects on serotonergic unit activity, in fects, in guinea pigs, 250 Rasmussen, K., see Foreman, M. M., 1270 behaving cats, 1359 Phosphoinositide hydrolysis, induced by en- Raszkiewicz, J. L., see Arneric, S. P., 310 mediation of DOM effects by, in rats, 127 dothelinpeptides, in human myomet- Raszkiewicz, J. L., see Decker, M. W., 319 rium, 973 Prostaglandin E, effects on ET-induced Rat insulinoma calls, AVP effects in, inhi- Phospholipase A2, inhibitor effects on AVP cAMP accumulation in anterior pi- bition by U-73122, 900 effects in rat insulinoma cells, 900 tuitary gland, in rat, 55 Rate constants, for ACE in vivo, 260 Phospholipase C 8-epi-Prostaglandin F2[cfiOJa[cfl], antiag- Ravens, U., see Ohler, A., 460 endothelin receptor binding, in human gregatory effects in platelets, in hu- Raynor, K., Kong, H., Hines, J., Kong, G., myometrium, 973 mans, 1192 Benovic, J., Yasuda, K., Bell, G. I. inhibitor effects on AVP effects in rat Prostanoids, F-series, antiaggregatory ef- and Reisine, T.: Molecular mecha- insulinoma cells, 900 fects in platelets, in humans, 1192 nisms of agonist-induced desensiti- N-Phosphonoacetyl-l-aspartate, resistance Prostate gland zation of the cloned mouse kappa to, effect of dipyridamole on, 480 alpha-i adrenoceptore, in human, canine opioid receptor, 1381 Physostigmine and rat, 722 Razdan, R. K., see Smith, P. B., 219 a42 nicotinic acatylcholine receptor ag- smooth muscle area density, in human, Reader, T. A., see Molina-Holgado, E., 713 onist effects, 768 canine and rat, 722 Reaven, G. M., see Donnelly, R., 809 1412 Index Vol. 270

Recombinant cytokines, effects on canine receptor complex agonists antagonize by three chemically dissimilar 5- parietal cells, 440 dizocilpine amnesia Putative role for HT agonists, 198 Red blood cells, see Erythrocytes allopregnanolone, 89 Segredo, V., see Caldwell, J. E., 1216 Reddy, S. T., see Masferrer, J. L., 1340 Roques, B. P., see Valverde, 0., 77 Seibert, K., see Masferrer, J. L., 1340 Reilly, T. M., see Hajj-Ali, A. F., 1152 Rothman R B. Cadet J. L, Akunne H. C. Seizures, neurosteroid effects against, 1223 Reinhardt-Maelicke, S., see Pereira, E.F.R., Silverthorn, M. L. Baumann M. H., Selenium, deficiency, effects on diquat tox- 768 Carroll F. I. Rice, K. C. de Costa B. icity and lipid peroxidation, in rats, Reisine, T., see Raynor, K., 1381 R., Partilla J. S. Wang, J.-B. Uhl G., 858 Relaxation, see also Vasodilation Glows J. R. and Derech C. M.: Stud- Self-administration, cocaine circular muscle, NANC, nitric oxide ies of the biogenic amine transport- effects of dopamine D-1 and D-2 antago- mechanisms in, in rabbit distal colon, are., 296 nists on, in rat, 209 929 Roy, A., see Nompleggi, D. J., 440 interactions with dopamine effects on Renal artery, adenosine receptors, in rat, RTI-55, multiple binding sites, in rat, 296 prolactin, in female rhesus monkeys, 893 Rubenfeld, J. M., see Unterwald, E. M., 1387 1110 Renal insufficiency, ibuprofen-associated Ryan J. W. Valido F. A., Sequeira M. J. Selig, W. M., see O’Donnell, M., 1282 nephrotoxicity in, 1307 Chung, A.Y.K. Berryer P., Chen X.- Selig, W. M., see O’Donnell, M., 1289 Renal tubules L. and Catravas J. D.: Estimation of Sensitization, see also Desensitization amantadine transport, in rat, 979 rate constants for reactions of pub- amphetamine, 690 proximal, cellular sodium-coupled uptake monary microvascular angiotensin binge cocaine, 1387 by platinum complexes in, 1097 converting enzyme with an inhibitor cocaine, genetic analysis, 1230 stereoselective secretion, in rat, 329 and a substrate in vivo, 260 opioid, during intestinal inflammation, in Renal vasoconstriction 2S-20499, effects on 5-HT responses, 198 mice, 386 5-HT1D-like receptor, in rabbit, 650 Saeki, T., see Ozaki, S., 1035 Septide-selective receptors, in guinea pig NArg, in rabbit, 1152 Saito, H., see Matsumoto, 5.-I., 498 bronchus, 1295 Renouard, A., see Millan, M. J., 958 Sakai, M., see Noach, A.B.J., 1373 Sequeira, M. J., see Ryan, J. W., 260 Renouard A., Widdowson P. S. and Millan Sakurai, S. Y., Kume, A., Burdette, D. E. Serotonin M. J.: Multiple alpha2 adrenergic and Albin, R. L: Quantitative auto- extracellular levels, cholinesterase inhib- receptor subtypes. I. Comparison of radiography of [3HJt-butylbicycboor- itor effects on, in rat, 277 [3HRJX821002-labeled rat thobenzoate binding to the -y-amino- inhibition ofacid secretion by, in rat, 1139 adrenergic receptors in cerebral cor- butyric acid receptorA complex, 362 metabolism, effects of neonatal 6-hydrox- tex to human HA,I,IZA adrenergic Salaices, M., see Arribas, S., 520 ydopamine on, in rat, 713 receptor and other populations of Salem, N., Jr., see Karanian, J. W., 1105 striatal dopamine release induced by, in aipha-2 adrenergic subtypes, 946 Salhab, A. S., DeVane, C. L, Medrano, T., rats, 1158 Renovascular hypertension, caffeine effects Buhi, W. C., Tebbett, I. R and Shiv- transporters, multiple [mnI]RTI55 bind- 1063 ing sites for, in rat, 296 in, crick, K. T.: Fetoplacental growth Renzetti, L, see O’Donnell, M., 1282 and placental protein synthesis in vasoconstrictor effects, in rabbit renal ar- Respiration, mitochondrial chain, effects of teries, 650 rats after chronic maternal cocaine nilutamide on, in rats, 167 Serotonin receptors administration, 392 Reuveny, E., see Nomura, K., 466 ligand 5-HT1B responses, in Chinese ham- Salicylamide, hepatic uptake, multiple in- Reynolds, W. A., see Perkins, K. A., 628 star lung fibroblasts and opossum dicator dilution study, in rat, 285 Rhodes, G. R., see Nichols, A. J., 614 renal epithelial cells, 938 Salivation, NPC-14695 inhibition, 546 Rice, K. C., see Rnthman, R B., 296 vasoconstrictor effects, in rabbit renal ar- Samanen, J. M., see Nichols, A. J., 614 Riley, D. P., see Black, S. C., 1208 teries, 650 Saphier, D., see Welch, J. E., 918 Rilmenidine, sympathoinhibitory effects, Serotonin syndrome, 5-HT1A agonist effects Saphier, D. and Welch, J. E.: Central stim- 572 on, 198 ulation ofadrenocortical secretion by Rinaldi, N., see O’Donnell, M., 1282 Serotonin1-like receptors, inhibition of acid 5-hydroxytryptamine agonists is Rinaldi, N., see O’Donnell, M., 1289 secretion by, in rat, 1139 mediated by sympathomedullary ac- Ristic, H. and Isaac, L: Pharmacological Serotonin receptors tivation, 905 characterization of dynorphin A (1- agonists Sarnyai, Z., see Teoh, S. K., 1134 17)-induced effects on spinal cord- effects on adrenocortical secretion, 905 Satoh, M., see Domae, M., 55 evoked potentials, 534 5-HT1A responses, 198 Sawyer, N., see Metters, K. M., 399 Ritanserin, mediation of DOM effects by, in pharmacological characterization, 1270 Sayeed, M., see Keshavarzian, A., 1057 rats, 127 unit responses, in behaving cats, 1345 Sbacchi, M., see 244 Rivet, J.-M., see Milan, M. J., 958 Wang, Y.-X., antagonist unit responses, in behaving Rivi#{232}re,P.J.M., Pascaud, X., Chevalier, E. SC-52608, reduction of infarct size by, 1208 cats, 1345 and Junien, J.-L: Fedotozine rever- Scatchard, K. M., see Knight, T. L., 1325 effects on acetylcholine efflux, in guinea sal of peritoneal-irritation-induced SCH23390, effects on cocaine self-adminis- pig, 656 ileus in rats: Possible peripheral ac- tration, in rat, 209 putative antagonist unit responses, in be- tion on sensory afferents, 846 SCH39166, effects on cocaine self-adminis- having cats, 1359 Rn 25-1553 tration, in rat, 209 SerotoninlB receptors, cellular responses, in bronchodilator studies, 1282 Schasteen, C. S., see Black, S. C., 1208 Chinese hamster lung fibroblasts and effects in pulmonary anaphylaxis, 1289 Schmets, L, see Berson, A., 167 opossum renal epitheial cells, 938 Rn 47-0203, see Bosentan Schmidt, W. E., see Jin, J.-G., 433 Serotoninm-like receptors, vasoconstrictor Roberts, A. J. and Keith, L. D.: Mineralo- Schreiber, M. D., see Covert, R. F., 118 effects, in rabbit renal arteries, 650 corticoid receptors mediate the en- Schwab, A. J., see Pang, K. S., 285 Serotonin2 receptors hancing effects of corticosterone on Schwartz, J.-C., see Bralet, J., 8 agonist effects on adrenocortical secre- convulsion susceptibility in mice, 505 Scierka, A., see Perkins, K. A., 628 tion, 918 Roberts, J., see Altiere, R J., 269 Scopolamine, impairment of passive avoid- effects in ethanol tolerance, 802 Roberts, L J. II, see Awad, J. A., 858 ance tasks by, effects of calcium role in METH-induced neurochemical al- Rnchette, C., see Metters, K. M., 399 channels in ameliorating effects of terations, 97 Rogawski, M. A., see Kokate, T. G., 1223 nefiracetam on, 881 vasoconstrictor effects, in rabbit renal ar- Rnlipram, airway effects, in guinea pigs, 250 Scott, E. P., see McLeod, H. L, 26 teries, 650 Romeo, E., Chancy, D. L., Zivkovic, I., Scott, P. A., Chou, J. M., Tang, H. and Serotonin receptors, mediation of DOM Costa, E. and Guidotti, A.: Mitochon- Frazer, A.: Differential induction of effects by, in rats, 127 dual diazepam-binding inhibitor 5-HT1A-mediated responses in vivo Shapiro, E., see Lepor, H., 722 1994 Index 1413

Sharma, M. L., see Caldwell, J. E., 1216 Spinal cord, nicotinic receptors in Takemori, A. E., see Miyamoto, Y., 37 Shebuski, R. J., see Hartman, J. C., 1071 intrathecal, cardiovascular and behav- Takinami, Y., see Nishida, A., 1256 Sheehy, R., see Wall, T. M., 681 ioral effects, 150 Tanaka, T., see Ohnishi, A., 342 Sheehy, R. M., see Hartman, J. C., 1071 ligand specificity, in rat, 159 Tang, H., see Scott, P. A., 198 Shen, T. Y., see Fisher, M., 702 Spinal cord-evoked potentials, dynorphin A Tang, L, Todd, R. D. and O’Malley, K. L: Shimada T. Yamazaki H., Mimura M. him, (1-17) effects on, 534 Dopamine D2 and D3 receptors in- Y. and Guengerich F. P.: Interindi- Spiperone hibit dopamine release, 475 vidual variations in human liver cy- effects on cocaine sell-administration, in Tang, R, see Lepor, H., 722 tochrome P-450 enzymes involved in rat, 209 Tang, T., Kiang, J. G. and Cox, B. M.: the oxidation of drugs carcinogens mediation of DOM effects by, in rats, 127 Opiolds acting through delta recap- and toxic chemicals: Studies with Spironolactone, mediation of effects of cor- tore elicit a transient increase in the liver microsomes of 30 Japanese and ticosterone on convulsions by, in intracellular free calcium concentra- 30 Caucasians, 414 mice, 505 tion in dorsal root ganglion-neuro- Shiotani, T., see Yamada, K., 881 Springer, S. A., see Teoh, S. K., 1134 blastoma hybrid ND8-47 cells, 40 Shiverick, K. T., see Salhab, A. S., 392 Standifer K. M. Cheng, J. Brooks A. I., Tannu, S. A., see O’Donnell, M., 1282 Sholar, J. W., see Mellon, N. K., 1110 Honrado C. P. Su, W. Visconti L. M., Tannu, S. A., see O’Donnell, M., 1289 Biedler J. L. and Pasternak G. W.: Sholar, J. W., see Teoh, S. K., 1134 Tatebayashi, H. and Narahashi, T.: Differ- Biochemical and pharmacological SHSY5Y calls ential mechanism of action of the characterization of mu, delta and differential regulation of mu and delta pyrethroid tetramethrin on tetrodo- kappa; opioid receptors expressed in opioid receptors in, 1086 toxin-sensitive and tetrodotoxin-re- BE(2)-C neuroblastoma calls, 1246 opioid desensitization in, 177 sistant sodium channels, 595 Star, R. A., see Ujiie, K., 761 Sieber, B.-A., see Giovanni, A., 1000 Taveira DaSilva, A. M., see Abrahams, T. Starke, K., see Urban, R., 572 Siguazodan, airway effects, in guinea pigs, P., 424 250 Stephens, R. L., Jr., see LePard, K. J., 1139 Steroids, cycbooxygenase regulation by, in Taylor, P., see Khan, I. M., 150 Silverthorn, M. L, see Rnthman, R. B., 296 Taylor, P., see Khan, I. M., 159 Simko, B., see O’Donnell, M., 1282 peritoneal macrophages, 1340 Stevens, C. W., see Brenner, G. M., 540 [3H]TBOB, see [HJt-Butylbicycboortho- Sitar, D. S., see Escobar, M. R., 979 benzoate SK&F 106760, in vivo pharmacological pro- Stiller, R. L., see Perkins, K. A., 628 Tebbett, I. R., see Covert, R. F., 118 ifie, 614 Stomach ulcers Tebbett, I. R., see Saihab, A. S., 392 Skolnick, P., see Faiman, C. P., 528 beta-3 agonist effects on, in rat, 559 Tedisamil, effects on human action poten- Smith, F. L, Brass, D. A., Dombrowski, D. effects of YM022 against, in rats, 1256 tial duration, 460 S. and Dewey, W. L.: Endogenous St-Pierre, S., see van Rnssum, D., 779 Telemetric blood pressure monitoring, cal- opioids released by suspending mice Strychnine-insensitive glycine receptors, feine effects on, in hypertension, by the tail selectively enhance spinal differential effects ofoompounds that 1063 mu opioid analgesia, 1177 act at, in punishment procedure, 528 Temperature, effects on amphetamine neu- Smith, P. B., Compton, D. R., Welch, S. P., Stuenkel, E. L., see Criswell, K. A., 1015 rotoxicity, in C57BLf6J mouse, 752 Razdan, R. K., Mechoulam, R and Stupans, I., see Murray, M., 645 Tenia coli, transmission by PACAP and Martin, B. R.: The pharmacological Su, W., see Standifer, K. M., 1246 VIP in, 433 activity of anandamide, a putative Subretrofacial nucleus, cardiovascular con- Teoh, S. K., see Mellon, N. K., 1110 endogenous cannabinoid, in mice, trol by, non-NMDA BAA receptor Teoh, S. K., Sarnyai, Z., Mendelson, J. H., 219 effects on, in cats, 424 Mello, N. K., Springer, S. A., Sholar, Smooth muscle Substance P, pulmonary edema induced by, effects of CGRP on, in rabbit, 30 J. W., Wapler, M., Kuehnle, J. C. and aortic, energy-force coupling, in rabbit, Gelles, H.: Cocaine effects on pulsa- 708 Sugg, E., see Corsi, M., 734 Sulfation, ofacetaminophen, impairment by tile secretion of ACTH in men, 1134 esophageal, ethanol inhibition of calcium rnolybdate, in rats, 1145 Terry, P., Witkin, J. M. and Katz, J. L: fluxes in, 1057 Sullivan, J. P., see Arneric, S. P., 310 Pharmacological characterization of myometrial cells, lindane effects on cal- Sullivan, J. P., see Decker, M. W., 319 the novel discriminative stimulus ef- cium in, in rat, 1015 Summer, W. R., see Greenberg, S., 1077 prostate, area density of, in human, ca- facts ofa low dose ofcocaine, 1041 Summers, K., see Cuadra, G., 277 Testosterone 6-hydroxylation, P450 3A- nine and rat, 722 Superoxide dismutase mimetic, reduction of pulmonary and venous, relaxation by fu- dependent, inhibition by oxazaphos- infarct size by, 1208 rosemide, comparison with mor- phorines, in human liver, 645 Suzuki, H., see Nozawa, Y., 566 9-Tetrahydrocannabinol, enhancement phine, 1077 of Svensson, B. E., see Kokate, T. G., 1223 TXA2-induced contractions, inhibitory ILl secretion by, 1334 Sweeney, C., see Keshavarzian, A., 1057 effects ofhydroxy fatty acids on, 1105 Tetramethrin, effects on sodium channels, Sympathoinhibition Smooth muscle-selective muscarinic antag- 595 rilmenidine, 572 onists, new, 546 Tetrapivaloyloxymethyl 1-(4-hydroxyphen- UK 14304, 572 Sodium channels, tetramethrin effects on, oxy)ethane-i,1-bisphosphonate, see Synthetic manganese-based superoxide cbs- 595 L-690,488 mutase mimetic, reduction of infarct Tetrodotoxin-resistant sodium channels, te- Sodium-calcium exchange, regulation by sizeby, 1208 Cafcalmodulin-dependent tramethrin effects on, 595 protein Szabo, B., see Urban, R., 572 kinase, medullary Tetrodotoxin-sensitive sodium channels, te- in bovine adrenal Szenohradszky, J., see Caldwell, J. E., 1216 calls, 104 tramethrin effects on, 595 Sodium-coupled uptake, by platinum corn- T3, see Triiodothyronine Tew, K. D., see Lacreta, F. P., 1186 plexes, in renal proximal tubular Tachycardia, atrial reentry, effects of pro- Thapar, P., see Zacny, J. P., 579 cells, 1097 cainamide and propafenone on excit- THC, see i9-Tetrahydrocannabinol Sodium-(±)-8-(3-methoxy-4-phenylsulfl- able gap in, in canine, 47 Thijssen, H.H.W. and Janssen, Y.P.G.: nylphenyl)pyrazolo[1,5-aJ-1,3,5-tria- Tachykinin receptors Target-based warfarin pharmaco- zine-4-olate monohydrate, see BOF- in guinea pig bronchus, 1295 kinetics in the rat: The link with 4272 on intestinal muscle cells, 236 the anticoagulant effect, SM Sonsalla, P. K., see Giovanni, A., 1000 Tada, K., see Fornal, C. A., 1345, 1359 Thomas, P. E., see Nims, R. W., 348 Sonsalla, P. K., see Giovanni, A., 1008 Tada, M., see Okazaki, K., 1319 Thompson, D. C., see Altiere, R. J., 269 Sonsalla, P. K., see Johnson, M., 97 TAK-044 Thompson, W. K., see Zacny, J. P., 579 Spermidine, effects on NMDA receptor ac- inhibition ofrenal vasoconstricton by, 269 Thromboxane, inhibitory effects of hydroxy tivation, 604 pharmacological proffle, in rat, 728 fatty acids on, 1105 1414 Index Vol. 270

Thromboxane A2 receptors, human periph- cephaloridine to carnitine transport and in combination with cocaine, eral blood monocyte, 446 and fatty acid metabolism in rabbit 1049 Thromboxane Aprostaglandin H2 recap- renal cortical mitochondria Struc- Vascular endotheial cells, XO effects on tore, F-series prostanoids binding to, ture-activity relationships, 873 Ca signaling in, 1197 in human platelets, 1192 TXA, see Thromboxane Vascular muscarinic receptors, lung, phar- Thyroxine-induced hyperthyroidism, des- U-46619, inhibitory effects of hydroxy fatty macological characterization, in rab- methylimipramine inhibition of [In1] acids on, 1105 bit, 269 Vascular smooth muscle, TXA2-induced 3,3’,S-T3 brain uptake in, in rats, 111 U-50488H, reversal of ileus by, in rats, 846 contractions, inhibitory effects of hy- Ticku, M. K., see Hu, X.-J., 485 U-73122, inhibition of AVP effects in rat droxy fatty acids on, 1105 TMQ analogs, see Trimetoquinol analogs insulinoma cells by, 900 Tocker, J. E., see O’Donnell, M., 1289 Uematsu, T. and Nakashima, M.: Pharma- Vasko, J. A., see Nichols, A. J., 614 Teds, N., see Ayajiki, K., 795 cokinetic and pharmacodynamic Vasoactive intestinal peptide see novel agonist Todd, H. D., Tang, L, 475 properties of a novel xanthine oxi- Tolerance, see also Dependence dase inhibitor, BOF-4272, in healthy bronchodilator studies, 1282 chlorpyrifos, in rats, 15 volunteers, 453 effects in pulmonary anaphylaxis, 1289 cocaine, genetic analysis, 1230 Uetrecht, J. P., Zahid, N. and Whitfield, D.: transmission in tenia by, 433 Vasoconstriction m-CPP, in rats, 127 Metabolism of vesnarinone by acti- DOM, in rats, 127 vated neutrophils: Implications for aortic, energj-force coupling in, in rabbit, ethanol, 5-HT2 receptor effects in, 802 vesnarinone-induced agranulocyto- 708 nicotine, in humans, 628 sis, 865 intrapulmonary, acatylcholine-induced, muscarinic receptors mediating, in Tolerance liability, imidazenil, in rat, 1262 Uhl, G., see Rothman, R. B., 296 Tolliver, B. K., Belknap, J. K., Woods, W. Ujiie, K., Hogarth L, Danziger R. Drewett, rabbit, 269 E. and Carney, J. M.: Genetic analy- J. G. Yuen P.S.T., Pang 1.-H. and renal ETB-mediated, inhibition by TAK-044, sis of sensitization and tolerance to Star R. A.: Homologous and heterol- cocaine, 1230 ogous desensitization of a guanylyl in rat, 728 Tomlinson, E. E., see Gordon, J. T., 111 cyclase-linked nitric oxide receptor in S-HT1D-like receptor, in rabbit, 650 NArg, in rabbit, 1152 Tomono, Y., see Ohnishi, A., 342 cultured rat medullary interstitial Tong, C., see Lothe, A., 1301 calls, 761 Vasodilation acetylcholine-induced, muscarimc recap- Tomcity, effects on epithelial transport, in UK 14304, sympathoinhibitory effects, 572 tore mediating, in rabbit intrapul- human colonic cell lines, 1373 Ulcers Tonini, M., see Ciccocioppo, R., 929 antral, effects ofbeta-3 agonists on, in rat, monary arteries, 269 Torgerson, L. J., see Covert, R. F., 118 559 adenosine analog, role of endotheium in, Torphy, T. J., see Underwood, D. C., 250 gastric and duodenal, effects of YMO22 in rat renal artery, 893 furosemide, comparison with morphine, Toxicity, see also Neurotoxicity against, in rats, 1256 cadmium and cis-diamminedichloropla- Undem, B. J., see Fernandes, L B., 1166 1077 KT-362, 851 tinum, metallothionein protection Underwood D. C., Kotzer C. J. Bochnowicz, against, IL-1 effects on, 1313 S. Osborn R. R., Luttmann M. A. NE-induced, mediation by beta receptors, cephaloridine, in rabbit renal cortical mi- Hay, D.W.P. and Torphy T. J.: Corn- in rat, 520 nicotine, in cat middle cerebral arteries, tochondria, 873 parison of phosphodiesterase III N 795 diquat and dual III N inhibitors on bron- Vasopressin, effects in human cerebral ar- effects of selenium deficiency and glu- chospasm and pulmonary eosinophil teries, 622 tathione-modulating agents on, in influx in guinea pigs, 250 Vasopressin receptors, human, 622 rats, 858 Unterwald, E. M., Ho, A., Rubenfeld, J. M. Vecuronium, pharmacology, in human vol- Frisoprostanes in, in rats, 858 and Kreek, M. J.: Time course of the unteers, 1216 ibuprofen-associated, in renal dysfunc- development of behavioral sensitize- Venable, D., see Masserano, J. M., 133 tion, 1307 tion and dopamine receptor up-regu- Ventral tegmental area, amphetamine ad- motor, neurosteroid, 1223 lation during binge cocaine adminis- ministered to, sensitization of nu- Trachea, electrical field stimulation of, re- tration, 1387 claus accumbens amphetamine leo- lease of inflammatory mediators by, Urban, G., see Keshavarzian, A., 1057 motor effects by, 690 in guinea pig, 1166 Urban, R., Szabo, B. and Starke, K.: Is the Ventricular myocardium, angiotensin H Transplantation, of fetal mesencaphalic sympathoinhibitory effect of rilmen- receptor subtypes, in bovine and hu- grafts, restoration of dopamine over- idine mediatadby a4,ha-2 adrenocep- man, 566 flow by, in rat striatum, 814 . tore or imidazoline receptors, 572 Ventricular myocytes Uric acid, serum level decrease by BOF- Tricycic antidepressants, inhibition of [IJ KN-62 effects on, in fetal mouse, 1319 4272, 453 3,3’,S-T3 brain uptake by, in rats, 111 KT-362 effects on ion currents in, in Utermahlen, W. E., Jr., see Nims, R. W., Triglyceride, metabolism of, gemfibrozil ef- guinea pig, 851 fects on, in Dahi salt-sensitive rats, 348 Verrees, J. F., see Winsauer, P. J., 142 809 Valido, F. A., see Ryan, J. W., 260 Vesnarinone, metabolism by neutrophils, 3,3’,S-Triiodothyronine3, brain uptake in- Valocik, R. E., see Nichols, A. J., 614 865 hibition by desmethylimipramine, in Valverde, 0., Maldonado, R., Fournie-Zalu- Vezina, P., see Perugini, M., 690 rats, 111 ski, M. C. and Roques, B. P.: Chole- Vila, J. M., see Martinez, M. C., 622 i-(3’,4’,S’-Trimethoxybenzyl)-6,7-dihy- cystokinin B antagonists strongly po- VIP, see Vasoactive intestinal peptide droxy-1,2,3,4-tetrahydroisoquinoline tentiate antinociception mediated by Visconti, L M., see Standifer, K. M., 1246 analogs, see Trimetoquinol analogs endogenous enkephalins, 77 Vitamin K cycle, effects on anticoagulation, Trimetoquinol analogs, as partial beta adre- Van Amsterdam, F.T.M., see Corsi, M., 734 in rat, SM nocaptor agonists, 665 Van Pelt, F.N.A.M., see Knight, T. L, 1325 Viu, E., see Faiman, C. P., 528 Trist, D. G., see Corsi, M., 734 van Rossum, D., M#{233}nard,D. P., Fournier, Voltage-sensitive calcium channels in car- Troponin, Ca interactions between heart A., St-Pierre, S. and Quirion, R.: Au- diomyocyte hypertrophy, 697 subunits, effects of MCI-1M and cal- toradiographic distribution and effects in ameliorating effects of nefira- feine on, in bovine, 831 receptor binding profile of [usI]Bol cetam, 881 Trullas, R, see Faiman, C. P., 528 ton Hunter-rat amylin binding sites Teal, A. W., see Prather, P. L., 177 in the rat brain, 779 Waid, P. P., see Howell, R. E., MS Tumor necrosis factor-a, effects on canine Vanover, K. E. and Woolverton, W. L: Be- Wakimasu, M., see Ikeda, S., 728 parietal cells, 440 havioral effects of the dopamine au- Wall, T. M., see Hartman, J. C., 1071 Thne, B. M. and Hsu, C.-Y.: Toxicity of toreceptor agonist PD 128483 alone Wall, T. M., Sheehy, R. and Hartman, J. C.: 1994 Index 1415

Role ofbradykinin in myocardial pre- the guinea pig: Agonist efficacy influ- Yamazaki, H., see Shimada, T., 414 conditioning, 681 ences functional activity in vivo, 656 Yan, Y.-T., see Yin, K., 1192 Wang, B., see Lepor, H., 722 Williams, M., see Arnaric, S. P., 310 Yano, M., see Ozaki, S., 1035 Wang, J.-B., see Rnthman, It B., 296 Williams, M., see Decker, M. W., 319 Yasuda, K., see Raynor, K., 1381 Wang, S. D., see Want, Y., 814 Winger, G., see Negus, S. S., 1025 Yasuda, S., see Ohnishi, A., 342 Wang, Y., Wang, S. D., Lin, S. Z. and Liu, Winsauer, P. J., Verrees, J. F., O’Halloran, Yin, K., Halushka, P. V., Yan, Y.-T., and J. C.: Restoration of dopamine over- K. P., Bixler, M. A. and Male, P. C.: Wong, P.Y.-K.: Antiaggregatory ac- flow and clearance from the 6-hy- Effects of chlordiazepoxide, 8-OH- tivity of 8-epi-prostaglandin R and droxydopamine lesioned rat striatum DPAT and ondansetron on radia- other F-series prostanoids and their reinnervated by fetal mesencephalic tion-induced decreases in food intake binding to thromboxane Ailprosta- grafts, 814 in rats, 142 glandin H2 receptors in human plate- Wang, Y.-X., Clarke, G. D., Sbacchi, M., Winship, D., see Keshavarzian, A., 1057 lets, 1192 Petrone, G. and Brooks, D. P.: Con- Witkin, J. M., see Terry, P., 1041 YMO22, antiulcer effects, in rats, 1256 Yohimbine, effects in kappa agonist-induced tribution of alpha-2 adrenoceptors to Wolf, C., see Berson, A., 167 diuresis, in rat, 244 kappa opioid agonist-induced water Wolfe, M. M., see Nompleggi, D. J., 440 Yoon, Y., see Lothe, A., 1301 diuresis in the rat, 244 Wong, LT.Y., see Eacobar, M. R, 979 Yu, H., see Lee, H.-C., 1171 Wapler, M., see Teoh, S. K., 1134 Wong, P.Y.-K., see Yin, K., 1192 Yuan, P.S.T., see Ujiie, K., 761 Wong, P. C., see Hajj-Ali, A. F., 1152 Ward, T. R, see Bushnell, P. J., 15 Yuki, H., see Nishida, A., 1256 Warfarin, target-based pharmacokinetics, Woods, J. H., see Negus, S. S., 1025 in rat, SM Woods, W. E., see Tolliver, B. K., 1230 Zacny, J. P., Lichtor, J. L., Thapar, P., Wasicak, J. T., see Arneric, S. P., 310 Woolverton, W. L, see Vanover, K. E., 1049 Coalson, D. W., Flemming, D. and Wasicak, J. T., see Decker, M. W., 319 Wozniak, K. M., see Aulakh, C. S., 127 Thompson, W. K.: Comparing the Wasserman, M. A., see O’Donnell, M., 1282 Wright, A., see Bboomquist, J., 822 subjective, psychomotor and physio- Wasserman, M. A., see O’Donnell, M., 1289 Wright, P.M.C., see Caldwell, J. E., 1216 logical effects of intravenous butor- phanol and morphine in healthy vol- Watanaba, T., see Ikeda, S., 728 Wu, D. and Cederbaum, A. I.: Characteriza- unteers, 579 Water diuresis, kappa agonist-induced, in tion of pyrazole and 4-methylpyra- Zadina, J. E., Harrison, L M., Ge, L-J., rat, 244 sole induction of cytochrome P45O2E1 in rat kidney, 407 Kastin, A. J. and Chang S. L: Differ- Water maze test, neurosteroids antagonism Wu, P. H., Liu, J.-F., Lan#{231}a,A. J. and ential regulation ofmu and delta opi- of dizocilpine effects, 89 Kalant, H.: Selective involvement of ate receptors by morphine, selective Weiss, It H., see Black, S. C., 1208 central S-HT2 receptors in the main- agonists and antagonists and differ- Welch, J. E., see Saphier, D., 905 tenanca of tolerance to ethanol by entiating agents in SH-SY5Y human Welch, J. E. and Saphier, D.: Central and arginine8-vasopressin, 802 neuroblastoma cells, 1086 peripheral mechanisms in the stim- Wyatt, R. J., see Masserano, J. M., 133 Zahid, N., see Uetrecht, J. P., 865 ulation ofadrenocortical secretion by Zardaverine, airway effects, in guinea pigs, the S-hydroxytryptamine2 agonist, Xanthine oxidase 250 (±)-1-(2,5-dimethoxy-4-iodophenyl)- BOF-4272 inhibitor, 453 Zeng, X.-P. and Burcher, E.: Use of selective 2-aminopropane, 918 effects on Ca signaling in vascular endo- antagonists for further characteriza- Welch, S. P., see Smith, P. B., 219 thelial calls, 1197 tion oftachykinin neurokinin-2, neu- Welton, A., see O’Donnell, M., 1282 Xie, J., see Greenberg, S., 1077 rokinin-1 andpossible “septide-selec- Walton, A., see O’Donnell, M., 1289 tive” receptors in guinea pig bron- Yadid, G., Pacak, K., Kopin, I. J. and Gold- chus, 1295 Wemlinger, T. A., see Hadjiconstantinou, stein, D. S.: Endogenous serotonin M., 639 Zhang, L, see Foreman, M. M., 1270 stimulates striatal dopamine release Zhang, W., see Lepor, H., 722 Wesson, D. E. and Elliott, S. J.: Xanthine in conscious rats, 1158 oxidase inhibits transmembrane sig- Thu, W., Newton, C., Daaka, Y., Friedman, Yaksh, T. L, see Khan, I. M., 150 H. and Klein, T. W.: h-Tetrahydro- nal transduction in vascular endothe- Yaksh, T. L, see Khan, I. M., 159 cannahinol enhances the secretion of lialcalls, 1197 Yamada, K., see Domae, M., 55 interleukin 1 from endotoxin-stimu- Whites Yamada. K., Nakayama, S., Shiotani, T. lated macrophages, 1334 erythrocyte COMT activity, ethnic differ- Hasegawa, T. and Nabeshima, T.: Zimmerman, B. G., see Chen, K., 491 ences, 26 Possible involvement of the activa- Zimmerman, S. A., Jones, M. W. and Har- interindividual P450 variations, 414 tion of voltage-sensitive calcium rison, N. L.: Potentiation of y-anii- Whitfield, D., see Uetrecht, J. P., 865 channels in the ameliorating effects nobutyric acicL receptor Cl current Whiting, P., see Pereira, E.F.R., 768 of nefiracetam on scopolamine-in- correlates with in vivo anesthetic po- Widdowson, P., see Milan, M. J., 958 duced impairment of performance in tency, 987 Widdowson, P. S., see Renouard, A, 946 a passive avoidance task, 881 Zivkovic, I., see Romeo, E., 89 Wilkinson, L 0., Middlemiss, D. N. and Yamada, S., see Nozawa, Y., 566 Zorub, 0., see Keshavarzian, A., 1057 Hutson, P. H.: 5-HT receptor acti- Yamaguchi, I., see Kuratani, K., 559 Zukin, S. R., see Javitt, D. C., 604 vation increases hippocampal acetyl- Yamano, M., see Nishida, A., 1256 Zumbado, M., see Fern#{225}ndez, L, 1121 choline efflux and motor activity in Yamasaki, Y., see Nozawa, Y., 566 Zweifel, B. S., see Masfarrer, J. L., 1340 METABOLISM AND DIiIiITION TheBioloolcalrate of Chemicals

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