Bracken. Supplementary Table 3. a Complete List of All Significantly Enriched Pcg Target Genes in Human Embryonic fibroblasts Anti-HA Anti-CBX8 Anti-SUZ12 Anti-K27me3
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Bracken. Supplementary Table 3. A complete list of all significantly enriched PcG target genes in human embryonic fibroblasts anti-HA anti-CBX8 anti-SUZ12 anti-K27me3 Gene name Description Gene ID MEAN Std Dev MEAN Std Dev MEAN Std Dev MEAN Std Dev Biological Process (Information extracted from DAVID http://apps1.niaid.nih.gov/david/) HOXD12 homeo box D12 NM_021193 4.446 0.319 3.574 0.529 2.945 0.528 Regulation of transcription, DNA-dependent. Development. HOXA11 homeobox protein A11 NM_005523 4.406 0.241 3.205 0.362 3.273 0.477 Regulation of transcription, DNA-dependent. Morphogenesis. OLIG2 oligodendrocyte lineage transcription factor 2 BC047511 4.117 0.379 3.189 0.244 2.999 0.386 Transcription. Regulation of transcription, DNA-dependent. Development. PHOX2B paired-like homeobox 2b NM_003924 4.685 0.233 2.869 0.706 2.721 0.316 Regulation of transcription, DNA-dependent. Development. Neurogenesis. SIM1 single-minded homolog 1 NM_005068 4.42 0.327 2.943 0.336 2.538 0.7 Transcription. Regulation of transcription, DNA-dependent. Signal transduction. Development. Neurogenesis. HOXA13 homeobox protein A13 NM_000522 3.728 0.517 3.166 0.696 2.958 0.979 Skeletal development. Regulation of transcription, DNA-dependent. Development. ZIC5 zinc finger protein of the cerebellum 5 NM_033132 4.279 0.315 2.562 0.479 2.95 0.613 LHX9 LIM homeobox 9 NM_020204 4.219 0.227 2.966 0.549 2.488 0.594 N/A Unknown (protein for MGC:15427) BC008699 4.286 0.463 2.298 0.379 2.934 0.495 HOXD13 homeo box D13 NM_000523 3.976 0.472 2.657 0.484 2.779 0.806 Skeletal development. Regulation of transcription, DNA-dependent. Transcription from RNA polymerase II promoter. Development, PAX3 paired box gene 3 isoform PAX3d NM_181458 4.171 0.497 2.296 0.523 2.795 0.31 Regulation of transcription, DNA-dependent. Transcription from RNA polymerase II promoter. Apoptosis. Development. Neurogenes PRDM13 PR domain containing 13 NM_021620 4.037 0.305 2.658 0.424 2.557 0.488 Transcription. Regulation of transcription, DNA-dependent. OLIG3 oligodendrocyte transcription factor 3 NM_175747 4.127 0.39 2.328 0.763 2.592 0.953 TAL1 T-cell acute lymphocytic leukemia 1 NM_003189 1.791 1.534 4.186 0.292 2.842 0.392 1.978 0.333 Transcription. Regulation of transcription, DNA-dependent. Cell proliferation . Cell differentiation. NKX2-5 " NK2 transcription factor related, locus 5" NM_004387 3.508 0.478 2.692 0.303 2.804 0.565 Negative regulation of transcription from RNA polymerase II promoter. Development. Heart development. HOXB9 homeo box B9 NM_024017 3.711 0.414 2.664 0.42 2.625 0.683 Regulation of transcription, DNA-dependent. Development. PAX-9 N/A U59628 3.894 0.437 2.958 0.354 2.102 0.587 Transcription. Regulation of transcription, DNA-dependent. Development. TLX3 " T-cell leukemia, homeobox 3" NM_021025 4.151 0.468 2.629 0.611 2.139 0.598 Regulation of transcription, DNA-dependent. Development. CYP26A1 " cytochrome P450, family 26, subfamily A, polypeptide 1 isoformNM_057157 2" 3.753 0.492 2.663 0.571 2.49 0.671 Electron transport. Metabolism. LGI3 leucine-rich glioma inactivated protein 3 AJ487518 3.615 0.555 2.582 0.658 2.684 0.556 N/A N/A AK026075 4.276 0.349 2.669 0.436 1.888 0.681 Regulation of cell cycle. Cytokinesis. Carbohydrate metabolism. Base-excision repair. FLJ32063 hypothetical protein FLJ32063 NM_153031 3.836 0.403 2.266 0.333 2.715 0.612 MEOX2 mesenchyme homeo box 2 NM_005924 4.075 0.534 2.148 0.429 2.542 0.545 Regulation of transcription, DNA-dependent. Development. Circulation. LHX1 LIM homeobox protein 1 NM_005568 3.811 0.442 2.903 0.796 2.009 0.906 Regulation of transcription, DNA-dependent. Neurogenesis. ZIC4 zinc finger protein of the cerebellum 4 NM_032153 4.079 0.383 2.701 0.549 1.928 0.878 N/A progesterone receptor B isoform AY382152 3.489 0.694 2.549 0.771 2.651 0.57 EVX1 even-skipped homeo box 1 NM_001989 3.661 0.429 2.078 0.223 2.917 0.543 SIX6 SIX6 protein BC065831 3.46 0.452 2.413 0.437 2.765 0.473 Regulation of transcription, DNA-dependent. Development. Visual perception. Organogenesis. CROC4 transcriptional activator of the c-fos promoter NM_006365 3.3 0.478 2.169 0.694 3.154 0.78 VGLL2 vestigial-like 2 isoform 1 NM_182645 3.986 0.503 2.279 0.619 2.342 0.709 Regulation of transcription. BARX1 BARX1 protein BC064363 2.831 1.001 2.992 0.765 2.767 0.89 Regulation of transcription, DNA-dependent. Regulation of transcription, DNA-dependent. Development. TLX2 " T-cell leukemia, homeobox 2 isoform 1" NM_016170 4.067 0.366 2.262 0.438 2.24 0.61 Regulation of transcription, DNA-dependent. Development. N/A N/A AK021601 4.357 0.32 1.46 0.537 2.713 0.386 FLJ20171 FLJ20171 protein BC067098 3.331 0.396 2.536 0.276 2.616 0.35 WT1 WT1 protein BC046461 3.819 0.629 2.266 0.576 2.365 0.745 Transcription. Regulation of transcription, DNA-dependent. Regulation of transcription, DNA-dependent. Cell cycle. KCNA1 " potassium voltage-gated channel, shaker-related subfamily, memberNM_000217 1" 3.287 0.54 2.432 0.607 2.685 0.678 Cation transport. Potassium ion transport. Muscle contraction. Synaptic transmission. PAX5 paired box 5 NM_016734 4.161 0.515 2.602 0.692 1.637 0.757 Transcription. Regulation of transcription, DNA-dependent. Transcription from RNA polymerase II promoter. Humoral immune response. GJB6 " gap junction protein, beta 6 (connexin 30)" NM_006783 3.07 0.59 2.551 0.835 2.751 0.798 Cell communication. Perception of sound. FOXB1 forkhead box B1 NM_012182 3.445 0.572 2.555 0.362 2.323 0.562 Transcription. Regulation of transcription, DNA-dependent. N/A Unknown (protein for MGC:70702) BC059780 2.688 0.434 2.38 0.312 3.225 0.449 HOXD9 homeo box D9 NM_014213 3.422 0.361 2.416 0.349 2.45 0.506 Regulation of transcription, DNA-dependent. Development. NR2E1 " nuclear receptor subfamily 2, group E, member 1" NM_003269 3.413 0.65 2.545 0.453 2.317 0.577 Transcription. Regulation of transcription, DNA-dependent. Development. Neurogenesis. HOXD8 homeo box D8 NM_019558 3.861 0.711 2.087 0.76 2.309 1.187 Regulation of transcription, DNA-dependent. Development. Determination of anterior/posterior axis, embryo. HCK hemopoietic cell kinase isoform p61HCK NM_002110 2.534 0.629 3.012 0.865 2.693 0.799 Protein amino acid phosphorylation. Intracellular signaling cascade. Mesoderm development. NEUROD1 neurogenic differentiation 1 NM_002500 3.588 0.313 2.044 0.392 2.524 0.681 Transcription. Regulation of transcription, DNA-dependent. Neurogenesis. Cell differentiation. LPL lipoprotein lipase precursor NM_000237 3.848 0.625 2.304 0.786 1.99 0.925 Fatty acid metabolism. Circulation. Lipid catabolism. ARX aristaless related homeobox NM_139058 3.24 0.465 2.566 0.502 2.268 0.779 Regulation of transcription, DNA-dependent. Development. HAND1 basic helix-loop-helix transcription factor HAND1 NM_004821 3.306 0.248 2.599 0.237 2.153 0.442 Regulation of transcription, DNA-dependent. Transcription from RNA polymerase II promoter. Development. NKX2-3 " NK2 transcription factor related, locus 3" NM_145285 3.129 0.629 2.155 0.291 2.759 0.494 TBX1 T-box 1 isoform C NM_080647 2.408 1.12 2.72 0.424 2.87 0.753 Regulation of transcription from RNA polymerase II promoter. Heart development. Morphogenesis. SNCB beta-synuclein NM_001001502 4.054 0.805 1.082 0.328 2.862 0.921 WIT-1 Wilms tumor associated protein NM_015855 3.713 0.417 2.208 0.421 2.068 0.334 Cell proliferation. N/A N/A AK125569 3.132 0.636 2.144 0.435 2.687 0.729 EN2 engrailed homolog 2 NM_001427 3.475 0.934 1.801 0.418 2.685 0.477 Regulation of transcription, DNA-dependent. Development. N/A N/A AK126665 2.745 0.419 2.61 0.552 2.588 0.449 N/A N/A AK123661 3.227 0.58 2.248 0.436 2.46 0.433 SIDT1 " SID1 transmembrane family, member 1" NM_017699 4.454 0.454 1.193 0.697 2.178 0.568 KIAA0322 N/A AB002320 3.263 0.56 2.043 0.796 2.519 0.689 Ubiquitin cycle. SPON1 " spondin 1, extracellular matrix protein" NM_006108 2.742 0.893 2.433 0.945 2.65 0.948 Cell adhesion. Development. BCAN brevican isoform 1 NM_021948 3.29 0.551 1.853 0.667 2.679 0.603 Cell adhesion. N/A N/A AK022595 3.709 0.534 2.414 0.548 1.679 0.583 Protein amino acid phosphorylation. Signal transduction. Alcohol metabolism. Lipid metabolism. Metabolism. DLX5 distal-less homeo box 5 NM_005221 3.162 0.899 1.925 0.487 2.687 0.889 Skeletal development. Regulation of transcription, DNA-dependent. Development. Neurogenesis. PRAC small nuclear protein PRAC NM_032391 3.769 0.483 1.915 0.83 2.089 0.578 FOXL2 forkhead box L2 NM_023067 3.344 0.696 2.237 0.665 2.184 0.575 Transcription. Regulation of transcription, DNA-dependent. ROBO3 " roundabout, axon guidance receptor, homolog 3" NM_022370 3.396 0.354 1.85 0.488 2.516 0.416 Chemotaxis. Neurogenesis. Sensory perception. Cell differentiation.