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The PureSYNAPSE™ Integrative Mental Health Protocol‡ Developed with James Greenblatt, M.D.+

Product Name Ingredients Function‡ Dosing

• P5P (activated B6) 10 mg • Cognizen® citicoline 125 mg • Provides daily cognitive support 2 capsules, CogniPhos • (citrate) 5 mg • Sharp-PS® GREEN • Promotes mental sharpness 1-2 times daily, with meals Order Code: CGP1 • Acetyl-l- HCl 500 mg 100 mg • Supports positive mood and behavior Capsules: Capsules and EasySticks®: Capsules: • Neurophenol® proprietary • Meriva® highly bioavailable • Provides daily cognitive support 1 capsule with blend providing 85 mg of turmeric phytosome 300 mg • Promotes mental sharpness breakfast and flavonoids from blueberry • Green tea extract 100 mg dinner and grape extracts • Supports mood and emotional wellness CurcumaSorb Mind EasySticks®: EasySticks®: Order Codes: • Neurophenol® proprietary • Oligopin® pine bark extract 1 stick pack, MCUM6 (Capsules) blend providing 28 mg of 25 mg sprinkled directly ‡ flavonoids from blueberry • Grape seed extract 100 mg in the mouth, with CMESB3 (EasySticks®) and grape extracts a meal. Powder will • Glycine 1,000 mg • Meriva® highly bioavailable require multiple turmeric phytosome 100 mg • Organic whole fruit blueberry mouthfuls. Take powder 900 mg with a beverage. • Sharp-PS® GREEN Powder can be phosphatidylserine 100 mg mixed with food. • Metafolin® 833 mcg DFE • Rhodiola rosea extract 100 mg • Supports production 3 capsules before (L-5-MTHF 500 mcg) • Grape seed extract 100 mg • Provides daily cognitive support breakfast and dinner DopaPlus • Zinc (picolinate) 10 mg • Green tea extract 100 mg • Promotes mental sharpness Order Code: DOP1 • L-Tyrosine 1,000 mg • P5P (activated B6) 6.7 mg TARGETED SUPPORT TARGETED

• Metafolin® 833 mcg DFE • Meriva® highly bioavailable • Supports multiple 2 capsules before (L-5-MTHF 500 mcg) turmeric phytosome 250 mg neurotransmitter systems breakfast and NeuroPure • Zinc (picolinate) 10 mg • Quercetin 100 mg • Supports mood and emotional dinner wellness Order Code: NOP1 • DL-phenylalanine 700 mg • P5P (activated B6) 6.7 mg • 5-HTP 100 mg • Supports healthy eating behavior • Metafolin® 833 mcg DFE • 5-HTP 100 mg • Supports serotonin production 2 capsules before (L-5-MTHF 500 mcg) • 500 mg • Promotes healthy eating breakfast and dinner SeroPlus • Ascorbic Acid 100 mg • 200 mg behavior Order Code: SOP1 • Niacinamide 20 mg • Supports occasional stress • P5P (activated B6) 6.7 mg • 100 mg • Zinc (picolinate) 10 mg

‡ Amino Replete • Comprehensive blend of free-form amino acids, provided in the • Promotes daily wellness 1 scoop before ratios found naturally in high biological value (BV) protein sources • Provides amino acid precursors breakfast Order Code: AMR5 of neurotransmitters

• Comprehensive blend of B • Provides essential cofactors for 1 capsule with B-Complex Plus • Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF), the naturally neurotransmission a meal Order Codes: occurring, universally metabolized form of 667 mcg DFE • Supports mood and emotional BCP6 / BCP1 (L-5-MTHF 400 mcg) wellness • Helps maintain neuronal health Digestive • Proprietary vegetarian enzyme blend 391 mg • Supports digestion of proteins 1 capsule with Enzymes Ultra • Betaine HCl 500 mg and other macronutrients each meal with Betaine HCl • Promotes daily wellness Order Codes: FOUNDATIONAL SUPPORT FOUNDATIONAL DEUB9 / DEUB1 Please note that patients may not require all supplements listed. continued on back +Dr. James Greenblatt is a retained consultant for Pure Encapsulations. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Available for download at PureEncapsulations.com/puresynapseprotocol

PEP-PSYN-0219 These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The PureSYNAPSE™ Integrative Mental Health Protocol‡ Developed with James Greenblatt, M.D.+

Product Name Ingredients Function‡ Dosing

‡ EPA/DHA • EPA/DHA (300/200 mg) • EPA/DHA (300/200 mg) 1 softgel with essentials breakfast, lunch and dinner Order Codes: ED19 / ED11 Magnesium • Magnesium 120 mg • Supports relaxation 1 capsule with (glycinate) • Maintains healthy neuronal breakfast, lunch and dinner Order Codes: function MG9 / MG1 / MG3 • Active cholecalciferol form of D 125 mcg (5,000 IU) • Promotes healthy gene 1 capsule before Vitamin D3 3 expression in the brain to breakfast 125 mcg (5,000 IU) support mood and cognition Order Codes:

FOUNDATIONAL SUPPORT FOUNDATIONAL VD56 / VD51 / VD52

Cognizin® is a registered trademark of KYOWA HAKKO BIO., LTD. Meriva® is a trademark of Indena S.p.A. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany. Neurophenol® is a registered trademark used under license by Pure Encapsulations. Oligopin® is a registered trademark DRT and licensed to Pure Encapsulations. Sharp-PS® GREEN is a registered trademark of Enzymotec Ltd. +Dr. James Greenblatt is a retained consultant for Pure Encapsulations.

Available for download at PureEncapsulations.com/puresynapseprotocol

490 Boston Post Road, Sudbury, MA 01776 USA ‡These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. ©2019 Pure Encapsulations, LLC. All Rights Reserved.