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Home , David Botstein, Ira Herskowitz, Seymour Benzer

Genetics Society of America

Records, Proceedings and Reports

Prepared for the Fifty-Seventh Annual Meeting Held in Conjunction with the XVI International Congress of Genetics Toronto, Canada August 20-27, 1988

Published supplementaly material in GENETICS, Volume 11 9 as ~~

Prepared by The Secretary

Anthony P. Mahowald Department of Genetics Case Western Reserve University School of Medicine Cleveland, Ohio 441 06

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BOARDS, COMMITTEES AND REPRESENTATIVES FOR 1988

BOARDDIRECTORS OF Gerald R. Fink, President Adelaide T. C. Carpenter Daniel L. Hartl, Vice-president William F. Dove Anthony P. Mahowald, Secretary William M. Gelbart Allan C. Spradling, Treasurer Nancy Kleckner Elizabeth W. Jones, Past President Carol S. Newlon John W. Drake, Editor Virginia Walbot

GENETICS EDITORIALBOARD John W. Drake, Editor Richard R. Hudson Sally Lyman Allen Nancy A. Jenkins John Avise Elizabeth W. Jones Dorothea Bennett Nancy Kleckner Cathy C. Laurie John E. Boynton Wen-Hsiung Li Benjamin Burr Robert L. Metzenberg Marian Carlson Gisela Mosig Adelaide T. C. Carpenter Jeffrey R. Powell Deborah Charlesworth John R. Roth Arthur Chovnick Trudi Schupbach Michael T. Clegg William F. Sheridan Victoria G. Finnerty Allan C. Spradling Roger E. Ganschow Steven D. Tanksley William M. Gelbart Elizabeth Thompson Barry W. Glickman Michael Turelli Maureen R. Hanson Bruce S. Weir Robert K. Herman

ADMINISTRATIVE OFFICE Gerry Gurvitch, ExecutiveDirector Pat Arnold, Receptionist Judy Ashton, Membership Aide Nina Bestall, Meetings Aide Peggy Gardiner, Meetings Manager Scott Hodgkins, Accounting Assistant Karen Gould, Comptroller Margot Kiley, Membership Coordinator Krista Koziol, Publications Assistant Jane Salomon, ABMG Coordinator

COMMITTEES Executive Adelaide T. C. Carpenter Gerald R. Fink Daniel L. Hartl Anthony P. Mahowald Allan C. Spradling Administrative Office Allan C. Spradling, GSA Treasurer, Chair Management Maimon M. Cohen, ASHG Treasurer David E. Comings, ASHG Preszdent Daniel L. Hartl, GSA Vice-president Neil A. Holtzman, ASHG Secretary Anthony P. Mahowald, GSA Secretary Education Myron Levine, Chair Shirleen Roeder Alan R. Templeton s;3

Graduate Student Travel Cathy C. Laurie, Chair Awards Anthony Griffiths Maynard V. Olson Donald L. Riddle Undergraduate Research Franklin W. Stahl, Chair Fellowships Michael R. Culbertson Mariana F. Wolfner

Genetic Stocks Roy Curtiss 111, Chair Nicholas W. Gillham, ATCC Representative Elizabeth H. Harris, Lower Eukaryotes Susan E. Lewis, Vertebrates Charles M. Rick, Plants Thomas B. Shows, Jr., Cells and Viruses Ronny C. Woodruff, Invertebrates

Honors and Awards , Chair Gerald R. Fink, ex officio Anthony P. Mahowald, ex officio Robert L. Metzenberg

Nominating Jonathan W. Jarvik, Chair Philip Anderson Ross J. Maclntyre Anthony P. Mahowald, ex officio

1989 Program Robert Horvitz, Chair Michael T. Clegg Daniel L. Hartl, ex officio Martha M. Howe Susan L. Lindquist GSA Secretary, ex officio Rodney J. Rothstein Travel Awards, XVI Interna- Peter J. Bruns, Chair tional Congress of Genetics Michael T. Clegg David R. Cox Michael R. Culbertson Nicholas W. Gillham G. Wesley Hatfield John C. Lucchesi Gail Mandel John R. Pringle David T. Sullivan

REPRESENTATIVES Council of the International William F. Dove Genetics Federation John W. Drake Jack von Borstel National Council on Radiation Seymour Abrahamson Protection Assembly of Life Sciences, Anthony P. Mahowald, ex officio National Research Council

Board of Trustees, American Nicholas W. Gillham Type Culture Collection s4

PAST AND PRESENT OFFICERS OF THE SOCIETY

President Vice-president Secretary-Treasurer 1932 L. C. Dunn F. D. Richey P. W. Whiting 1933 R. A. Emerson P. W. Whiting 1934 Sewall Wright D. F. Jones P. W. Whiting 1935 D. F. Jones P. W. Whiting M. Demerec 1936 P. W. Whiting L. J. Stadler M. Demerec 1937 E. M. East L. J. Cole M. Demerec 1938 L. J. Stadler M. Demerec E. W. Lindstrom 1939 M. Demerec B. McClintock E. W. Lindstrom 1940 L. J. Cole Th. Dobzhansky E. W. Lindstrom 1941 Th. Dobzhansky E. W. Lindstrom B. P. Kaufmann 1942 E. W. Lindstrom M. M. Rhoades B. P. Kaufmann 1943 M. M. Rhoades G. W. Beadle B. P. Kaufmann 1944 A. H. Sturtevant B. P. Kaufmann L. H. Snyder 1945 B. McClintock P. C. Mangelsdorf L. H. Snyder 1946 G. W. Beadle Karl Sax L. H. Snyder 1947 H. J. Muller L. H. Snyder M. R. Irwin 1948 L. H. Snyder T. M. Sonneborn M. R. Irwin 1949 T. M. Sonneborn Curt Steven M. R. Irwin 1950 Curt Stern M. R. Irwin W. R. Singleton

Sewetary Treasurer 195 1 M. R. Irwin J. W. Gowen W. R. Singleton E. W. Caspari 1952 J. W. Gowen R. E. Clausen W. R. Singleton E. W. Caspari 1953 R. E. Clausen W. R. Singleton C. P. Oliver E. W. Caspari 1954 J. T. Patterson R. A. Brink C. P. Oliver N. H. Giles, Jr. 1955 P. C. Mangelsdorf R. E. Cleland C. P. Oliver N. H. Giles, Jr. 1956 R. E. Cleland J. L. Bush H. B. Newcombe N. H. Giles, Jr. 1957 R. A. Brink C. P. Oliver H. B. Newcombe R. D. Owen 1958 C. P. Oliver J. F. Crow H. B. Newcombe R. D. Owen 1959 Karl Sax J. W. Boyes W. L. Russell R. D. Owen 1960 J. F. Crow H. B. Glass W. L. Russell D. Schwartz 1961 B. P. Kaufmann R. D. Owen W. L. Russell D. Schwartz 1962 R. D. Owen W. L. Russell E. B. Lewis D. Schwartz 1963 Jack Schulz S. Emerson E. B. Lewis E. Novitski 1964 S. Emerson H. L. Roman E. B. Lewis E. Novitski 1965 W. L. Russell E. W. Caspari R. P. Wagner E. Novitski 1966 E. W. Caspari E. B. Lewis R. P. Wagner A. H. Sparrow 1967 E. B. Lewis H. L. Roman R. P. Wagner A. H. Sparrow 1968 H. L. Roman C. Yanofsky B. Wallace A. H. Sparrow 1969 C. Yanofsky N. H. Giles, Jr. B. Wallace D. R. Stadler 1970 N. H. Giles, Jr. R. P. Wagner B. Wallace D. R. Stadler 197 1 R. P. Wagner R. D. Hotchkiss M. W. Shaw D. R. Stadler 1972 R. D. Hotchkiss M. M. Green M. W. Shaw G. Lefevre 1973 M. M. Green B. Wallace M. W. Shaw G. Lefevre 1974 B. Wallace 0. Smithies B. H. Judd G. Lefevre 1975 0. Smithies E. S. Russell B. H. Judd D. Lindsley 1976 E. S. Russell D. D. Perkins B. H. Judd D. Lindsley 1977 D. D. Perkins M. Shaw G. R. Fink D. Lindsley 1978 M. Shaw E. Sears G. R. Fink W. Welshons 1979 E. Sears W. K. Baker G. R. Fink W. Welshons 1980 W. K. Baker B. H. Judd D. T. Suzuki W. Welshons 1981 B. H. Judd H. L. Carson D. T. Suzuki A. Chovnick 1982 H. L. Carson M. L. Pardue D. T. Suzuki A. Chovnick 1983 M. L. Pardue R. W. Allard H. W. Lewis A. Chovnick 1984 R. W. Allard I. Herskowitz H. W. Lewis R. E. Esposito 1985 I. Herskowitz D. L. Lindsley H. W. Lewis R. E. Esposito 1986 D. L. Lindsley E. W. Jones A. P. Mahowald R. E. Esposito 1987 E. W. Jones G. R. Fink A. P. Mahowald A. C. Spradling 1988 G. R. Fink D. L. Hard A. P. Mahowald A. C. Spradling

Editors G. H. Schull(1916-1925) C. Stern (1947-1951) F. W. Caspari (1968-1972) D. E. Jones (1926-1935) R. A. Brink & J. F. Crow (1952-1956) D. R. Stadler (1973-1976) L. C. Dunn (1936-1939) C. P. Oliver & W. S. Stone (1957-1962) G. Lefevre (1977-1981) M. M. Rhoades (1940-1946) D. D. Perkins (1963-1967) J. W. Drake (1982-1991) s5

BYLAWS OF OF AMERICA (Revised June 9, 1986)

The Genetics Society of America is organized to the nominees for Secretary. The Treasurer is also provide facilities for association and conference elected every third year, but not in the same year amongstudents ofgenetics, to promote the com- that the Secretary is elected. munication and publication of scientific knowledge, Six members of the Board of Directors, who hold to promote education and research in genetics, and no other office, shall be elected by the membership. to encourage interaction between workers in genetics Ballots for these positions shall bear the names of and those in related sciences. twice as many candidates as there are openings. The ARTICLE1. Membershi$.-All persons interested in two nominees receiving the highest number of votes genetics shall be eligible for active membership. Any shall be elected each year to serve for three years. person who hasbeen an active member of the Society Terms of all members of the Board shall begin on continuously for 20 years and whohas retired, is January 1 of the year following their election, and eligible for emeritus membership. All organizations shall end on December 31 of the year ending their interested in any field of genetics shall be eligiblefor term. sustaining membership. Each sustaining member ARTICLE3. Meetings.-An annual meeting open to shall have the privilege of being represented at any the entire membership of the Society shall beheld at meeting of the society by one delegate appointed by a time and place designated by the Board of Directors. the sustaining member. Such delegates shall be eli- The annual business meeting of the membership gible to hold office only if they are active members. shall be held during the annual meeting, at which ARTICLE2. Officers and the Board of Directors.-The the Board of Directors shall make its annual report officers of the Society shall be a President, a Vice- to the membership including the results of the elec- President who is also President-Elect, a Secretary, tion of officers. Special meetings may be called by and a Treasurer. They, together with the immediate the Board of Directors. Fiftymembers shall constitute Past-President, the Editor ofGENETICS, and six a quorum forany annual or special businessmeeting. other members elected by the Society shall constitute The program shall be arranged by the Secretary the Board of Directors. Each board member shall in accordance with the program rules adopted by the have one vote. The Board shall meet at least once Board ofDirectors. The Board of Directors may each year. Additional meetings may be called by the arrangefor joint programs with related scientific President. societies, and for presentation of invitation papers. ExecutiveCommittee: The Executive Committee of ARTICLE4. Amendments.-Amendments to these the Board of Directors shall consist of the President, Bylaws may be adopted at the annual meeting by a Vice-president, Secretary, Treasurer, and oneof the two-thirds vote of the members present and voting, elected Directors selected by the whole Board at its provided that any proposed amendment, signed by annual meeting. The Executive Committee shall act five members, has been submitted in writing to the by majorityvote in matters thatrequire attention Secretary at least three months before the annual between regular Board meetings. meeting, and has been communicated to the members Election of Officers and Tmof Office: The officers of the Society at least two weeks before the annual of the Society shall be elected by a simple majority meeting. of ballots cast by members of the Society. Each year ARTICLE5. Dues.-Annual dues for various classes the nominating committee shall submit the names of of members shall be fixedby the Board of Directors. at least two nominees for each position to be filled, Duesshall include a subscription to GENETICS. taking into consideration candidates suggested to the Graduatestudents who provide evidenceof their Secretary or theChair of the Nominating Committee. status are entitled to active membership at half the The ballot, mailed to all members, shalllist the regular dues, for a period not exceeding five years. nominees and also provide spaces for write-in votes. Husbands andwives both qualifying for membership At the end of the first year of service the Vice- individually may elect a combined membership en- President shall automatically become President and titling them to a single subscription to GENETICS, shall serve for one year in that capacity, and for one while entitling each of them to be listed as a member full year thereafter as a Director. That officer will and to vote. Emeritus members may elect tocontinue therefore serve for three full years on the Board of to receive GENETICS by paying halfthe regulardues, Directors. Every third year the ballot shall include or they may elect not to receive the journal and be s6 exemptfrom paying dues. Dues from sustaining Board and the Board ofDirectors, take measures members shall include one subscription to GE- necessary to assure an adequate income. NETICS. Payment for all classes of membership shall ARTICLE7. AdministrativeOffice.-An administra- be due January 1. New members shall be billed for tiveoffice shall be maintained for conducting the dues from the previous January 1 and shall receive business of the Society. It shall attend to such other GENETICS for the entireyear. Members whosedues matters as dictated by the Board of Directors. Super- are in arrears may expect not to receive publications visionof the administrative officeshall be the re- or communications of the Society and shall be ineli- sponsibility of the Administrative Director, who shall gible to vote. Members in arrears for one year shall implement the policies decided by the Board of be dropped from the rolls. A member who has been Directors. The Administrative Director shall provide dropped for nonpayment of dues may be reinstated staff support, as needed, to assist the officers of the on written request to the Secretary, accompanied by Society to carry out their responsibilities. The Presi- payment of dues for the year in which reinstatement dent shall have ultimate authority for the adminis- is desired. trative office and resolution of any conflicts related ARTICLE6. Publications.-The Society shall publish to it. GENETICS as its official journal. Subscription to the ARTICLE8. Duties of Officers.-The President shall Journal shall be considered an integral part of active preside at the meetings of the Society and the Board and sustaining membership. The subscription rate to of Directors. With the advice of the Board of Direc- nonmembers shall be set by the Board of Directors, tors, the President shall appoint such committeesand and shall be not less than the level of dues for active representatives asmay be needed. The Vice-Presi- members of the Society. dent shall preside in the absence of the President. In GENETICS shall be a periodical record of investi- the event of a vacancy in the office of President, the gation into heredity and variation. Publication in the Vice-president shallbecome President forthe re- Journal shall be open to members and nonmembers mainder of the unexpired term. In the event of a alike.Acceptance shall be decided after editorial vacancy in the office of Vice-president, Secretary or review, solely on the basis of merit and suitability. Treasurer, the Board of Directors shall appoint an Editorial Board. An Editorial Board of GENETICS active member to servefor the remainderof the year, shall be appointed by the Board of Directors, and andthe officeshall be filled atthe next annual shall consist of an appropriate number decided upon election. by the Board of Directors. Each member shall nor- The Secretary, in cooperation with the administra- mally serve a three-year term. The Editor shall be tive office, shall (1) keep the records of the Society; appointed by the Board of Directors for a term of (2) direct the arrangement of meeting plans in ac- five years, but such appointment may be extended cordance with the rules formulated by the Board of or terminated at any time by a two-thirds vote of the Directors and function ex officio with the Committee Board of Directors. The Editor shall be consulted in on Meeting Programs; (3) send to all members the discussions about term of appointment, but shall not dateand place ofthe annual meeting, a call for vote. The Board of Directors and theEditorial Board papers to be presented at that meeting, and a call shall advise the Editor in matters relating to Journal for suggestions for nomination for all offices to be policy, and shall with the Editor determine editorial filled by election. Not later than one month before policy for the Journal in all respects not specified by the annual meeting the Secretary shall send all mem- these Bylaws. bers a ballot bearing the names of nominees for The Editor ofGENETICS shall carry out policy office. (4)The Secretary shallprepare minutes of the decisions of the Board of Directors, and shallbe annual meeting, and shall present an annual report authorized to act for the Editorial Board in arriving to the members concerning actions of the Board of at editorial decisions and in conducting routine busi- Directors, activities of the Society and its committees ness. The Editor shall arrange meetings of the Edi- and representatives, andthe membership of the torial Board as necessary, or upon written request of Society; and (5) deposit those records of the Society, three members of the Editorial Board. The Editor no longer needed for current business, in the histor- shall preside over meetings of the Editorial Board, ical collection of the Library of the American Philo- and shall cast the deciding vote in case of a tie. The sophical Society. Editor shall, on request, communicate recommen- The Treasurer shall (1) have charge of all funds dations of the Board of Directors, or of Society of the Society and be responsible for their investment, members, to the Editorial Board, and shall represent (2) be bonded in an appropriate amount fixed by the the Editorial Board in dealing with the Board of President, (3) send to all members bills for annual Directors. The Editor shall submit an annual report duesand (4) prepare an annual statement to the to the Society regarding the operationof GENETICS. members of the financial status of the Society, to be The Editor shall, in cooperation with the Editorial audited by a certified public accountant. (5) The s7 Treasurer shall also provide the Administrative Di- areas of genetics. In addition, the Secretary shall be rector and Editor of GENETICS with funds necessary ex officio a non-voting member of the committee. No to operate the administrative office and to produce person shall serve as a voting member on the Nom- the Journal. inating Committee more than once during any four- AmmxE9. Committees: NominatingCommittee.-A year period. Nominating Committee shall be named each year by Other Committees: The President shall create and the Board of Directors and shallconsist of three appoint members tosuch other committeesas are active Society members who are not members of the deemed necessary or advisable by the Board of Board and who include representatives of different Directors.

PROCEEDINGS OF THE 56TH ANNUAL BUSINESS MEETING June 14, 1987 Hilton Hotel, San Francisco,

The meeting was calledto order at 1:30p.m., Meeting ($12,682). Expenses exceeded income for President E. W. Jones presiding. both the GSA meeting and the Yeast Genetics and Approval of Minutes: The minutes of the June 9, Molecular meeting by a total of $31,760. 1986, Business Meeting as published in the 1987 The accounting system used by the Society is being Supplement to GENETICS (Vol. 116, No. 1, Part 2) modified to reflect the true cost ofindividual activities were approved. such as meetings and maintenance of membership Secretary’s Report (A. P. Mahowald): The results of records. The changes involve the allocationof an the election for positions whose term begins January appropriate shareof Administrative Office expenses 1, 1988, were announced as follows: to a specific Society function. Under the old system, Vice President: D. L. Hart1 the costs incurred in managing meetings appeared Directors: A. T. C. Carpenter and W. M. Gelbart to be lower than in the new system because Admin- One thousand and ninety-nine ballotswere cast, istrative Office expenses associated with organizing representing 42% of the members eligible to vote. the meetings werenot recognized as suchon financial The members of the Nominating Committee were statements. B. Hall (Chair), S. Lindquist, J. Kermicle, and The 1987 budget estimates include $950,730in A. Mahowald, ex officio. receipts and $929,800in disbursements, for a net The Society’s records indicate that there are 2,821 balance of $20,930. Sources of income will be similar paid members, distributed as follows: 2,268 regular to those in 1986, but costswill increase inseveral members (including 238 husband-wife members), areas, mostnotably the publicationof GENETICS 385 student members, and 168 emeritus members. and Administrative Office expenses associated with In June 1986, total paid membership was 2,619, so the new capabilities and duties of the staff. there has been an increase. Approximately 464 per- Income derived from invested assets has assumed sons had registered for the 1987 GSA Annual Meet- an increasingly important role in maintaining the ing. Society’s financial equilibrium. In January 1987 the Treasurer’s Report (A. C. Sprudlzng): The GSA re- Board of Directors voted to invest up to $150,000 in mains in excellent financial health. An audited finan- socially responsible stocks in order to. diversify GSA’s cial statement detailing the assets,income and ex- holdings and help ensurea steady level ofinvestment pendituresduring the year ended December 31, income. As of May 3 1, 1987, the Society owned stocks 1986, has been prepared; details appear in the 1987 valued at about $70,000, or 6% of total assets, plus Supplement to GENETICS. To summarize: during Certificates of Deposit ($504,000) and U.S. Govern- 1986 the Society’s assets increased from $1,057,715 ment Securities ($541,000). to $1,148,902 due to income of $982,818 and ex- Member dues for 1988 will increase by $5. penses of $89 1,631. The principal sources of income Editor’s Report (J. W. Drake): Net income from remain GENETICS (net approximately $143,000) and GENETICS is decreasing because more pages are interest from investedassets (net approximately being printed. In 1986, the number of pages reached $100,000). The Society expended $74,700 in awards, an all-time high since 1916, resulting in an additional including 25 undergraduate summer fellowships $50,000 in production costs. The larger format has ($60,000) and 60 student travel awards to the Annual provided some offsetting savings. Institutional sub- S8 scriptions will increase from $195 to $210 in 1988. chemicals. The initialinvitation to affiliate will be Those whowish to contribute articles for the new sent to yeast and Drosophila researchers who are not “Perspectives” column should contact W. Dove or members of GSA. Both groups have begun to form J. Crow. organizing committees that will interact with the GSA Starting September 1987, authors will be sent page Board on such matters as meeting management, and proofs instead of galley proofs, and the journal will the Board anticipates that other organismal groups be mailedon the 27th or 28th of the month preceding will follow suit. While GSA sponsorship of the yeast date ofissue. These measures should saveseveral meetings in 1986 and 1987 meant underwriting the days in production time. finances as well as providing logistical support, the Memberswho do not need their copiesof GE- Board hopes to have specialty meetings stabilize with NETICS may ask to have them sent to members of registration fees sufficient to break even. the International Genetics Federation in developing Student Awards Program: While the Undergraduate countries. Research Fellowship program is very competitiveand Future Meetings: The 29th annual Drosophila con- will continue, the Graduate Student Travel Awards ference will be held August 17-20, 1988, in Toronto program does not seem to attract as many students and willbe managed by the GSA Administrative to GSA meetings and membership as intended. The Office. The XVI International Congress of Genetics Board has therefore decided to terminate the pro- will be held August 20-27, 1988, in Toronto and the gramafter 1988. There wereobjections from the GSA meeting will be subsumed therein. The annual floor by members who saidthat theprogram provides GSA Business Meeting and theawards ceremony and a valuable and much appreciated experience for reception will be held during the Congress. P. Bruns students. They suggested that the program be cur- is seeking funds to support travel to the Congress. tailed rather than abandoned and that student ap- In 1989, the GSA meeting will again be held in plicants be required to be GSA members. Jones said tandem with the Yeast Genetics and Molecular Bi- the Board would take these suggestions into consid- ology meeting in June. In 1990, the GSA will meet eration.* jointly with the Genetics Society ofCanada. W. Sher- Other Business: It was suggested that GSA resume idan suggested thatthe Board consider meeting the practice of providing roommate service for meet- jointly with the developmental biologists. ing registrants. Jones said this could be investigated Affiliation: On June 13, 1987, the GSA Board of as long as such activitywould not present liability Directors voted to create a category of affiliateship problems. A. Templeton has been asked to explore with GSA in order to attract scientists who do work the possibility of collecting computer materials for related to genetics but who do not consider them- teaching genetics. selves geneticists. For an annual fee less than that paid by a member, an affiliate would be entitled to a Respectfully submitted, number of benefits, including a copy of the mem- ANTHONYP. MAHOWALD,Secreta9 bership directory (in which affiliates will be listed), a GERRYGURVITCH, Recording Secretary copy of the program and abstracts volume for his or her meeting (whether or not he or she registered), access to discount journal subscriptions offered by * At its January 1988 meeting, the Board voted that in 1989 CSA will GSA, and access to consortium bulk purchase of fund a maximum of thirty Graduate Student Travel Awards.

REPORT OF THE COMMITTEE ON HONORS AND AWARDS

The Societymakes two awards annually to honor awarded to Norman H. Giles andthe 1988 GSA members who have made outstanding contributions Medal willbe awarded jointly to DavidBotstein and to the science of genetics. The Thomas Hunt Morgan . The awards will be presented at 5 Medalrecognizes a lifetime contribution togenetics. p.m., Tuesday, August 23rd, at the XVIth Interna- The GeneticsSociety of America Medal recognizes tional Congressof Genetics, Toronto, Canada. particularly outstanding contributions to genetics within the past fifteen years. We are pleased to report that thethat 1988 ThomasHunt MorganMedal will be CHARLESYANOFSKY, Chair s9 1988 : Norman H. Giles

Since 1981, the Genetics Society of America has his finest work since his “retirement.” However, he annually awarded the Thomas Hunt Morgan Medal and his wife Doris, have been able to find more time to a scientistwho, during a lifetime of research, for bird-watching in remote places. Trips to Hudson teaching, and service, has made an especially large Bay and to Papua New Guinea are imminent. impact on the field of genetics. This year’s medalist, Over the years, Norman Giles has shown that he Norman H. Giles, fully upholds that tradition. has an uncanny eye not only for birds, but for what Norman Gileswas born in Atlanta, Georgia, in is important and permanently interesting in genetics. 1915. During childhood, he developed what was to Subjects that have caught his attention have the be a lifelong fascinationwith . He physiological nature of the as a unifying theme. attended college at Emory University, and then stud- His earlier published works (1939-55) were on mi- ied with Karl Sax at Harvard, receiving his Ph.D. in crosporogenesis and aberrations in Tra- 1940. After a year asa postdoctoral fellow, he became descantia. His first use of Neurospora as an experimen- instructor of botany at Yale and advanced through tal organism came closely after the original publica- the academic ranks. From 1947-50, he was principal tion of Beadle and Tatum and dealt with reversions biologist at Oak RidgeNational Laboratory, after of nutritional mutants-results which he still remem- which he returned to Yale. He was named Eugene bers as among his most satisfying.A series of impor- Higgins Professor of Genetics in 1961. A sabbatical tant papers followed, their subject matter ranging visit in 1959-60 to the University Genetics Institute from intragenic complementation and gene conver- of Copenhagen, as a Fulbright and a Guggenheim sion to gene clusters andthe molecularbasis of fellow, and a visitas a Guggenheim fellowto the regulation of gene activity. During this time, he Australian National University in 1966, were impor- attracted and inspired a number of younger scientists tant in helping him open up new lines of research. who went on to highly productive careers. In 1972, he returned to his native state, becoming A keyassociation has been his three decades of Fuller E. Callaway Professor of Genetics at the Uni- collaboration withMary E. Case. Their studies on versity of Georgia, Athens. the cluster of which regulates quinic acid His honors include, among many others, election utilization in Neurospora have progressed from nutri- to the National Academy of Sciences, U.S.A.; to the tional phenomenology in 1970 to the present, pro- Royal Danish Academy of Sciences and Letters; to viding some of our most detailed molecular insights presidency of the Genetics Society of America(1970) into eukaryote gene regulation. and to presidency of the American Society of Natu- ralists (1977). In 1986, he took on emeritus status. ROBERTL. METZENBERG Not one to rest on his laurels, he has done some of

1988 Genetics Society of America Medal: David Botstein and Ira Herskowitz

David Botsteinand Ira Herskowitz haveeach made Botstein was involved in some of the early work in outstanding contributions to the fieldsof genetics yeast and developed several im- and molecular biology.Both started their careers portant host strains and plasmids. His work on yeast working on gene expression in : Bot- also has included studies of the regulation of a family stein in the Salmonella phage 22 and Herskowitz in of genes involvedin sucrose utilization. With his phage lambda. Both then switched their attention to student Marian Carlson, he discovered a novel mode yeast. The yeast world, for the better, has not been of regulation of one of these genes. He studied the the same since. genes coding for tubulin synthesis and the role of David Botstein workedon themechanisms ofhead these and other genes in cell division. In a different assembly, DNA encapsulation and DNA replication arena, David Botstein and collaborators in 1980 pro- in P22. He advanced the important concept of anal- posed the use of restriction fragment length poly- ysis of conditional lethal isolated as sup- morphisms (RFLPs) as genetic markers and, in par- pressors of genes coding for components of a struc- ticular, the use of RFLPs tomap the humangenome. tural complex as a means of identifying genes coding This approach is now being used in several labora- for other components of this complex. He also pro- tories to obtain detailed maps of human and other posed the useof reciprocal temperature shifts of genomes and clearly represents a major advance in differentially conditional mutations to establish the the genetic analysis of complex genomes. temporal sequence of function of these mutations. DavidBotstein was born in Zurich, Switzerland SI0 and was educated at Harvard and the University of differentiation. He and hisassociates have isolated Michigan. He was Professor of Genetics at Massachu- and analyzedmost of the genesinvolved in this setts Institute of Technology from 1967 until his very complex system. With Janet Kurjan, he isolated the recent move to the west coast to become Vice Presi- genefor one of the mating pheromones and has dent for Science at Genentech. He is a member of shown that it codes for a secretory-signal sequence the National Academy of Sciences. as well as for four copies of the pheromone. He has Ira Herskowitz studied the regulation of genes in alsoisolated the gene that controls mating type phage lambda, including sites that control a set of switching. late genes and the C1 gene. He did important re- Ira Herskowitz was born inBrooklyn and was search on host genes that control DNA replication of educated at the California Institute of Technology lambda. His work on yeast has been equally signifi- and Massachusetts Institute of Technology. He was cant. With his students, he has analyzed the complex on thefaculty ofthe from 1972 homothallism-heterothallism system, which had been to 1981. He is a member of the National Academy described but not understood for manyyears. On ofSciences. Since 198 1 he hasbeen Professor of the basisof a seriesof elegant experiments, Ira Genetics and Head of the Division of Genetics at the Herskowitz advanced the cassette model of mating University of California at San Francisco. type regulation and this model has become a para- digm for eukaryotic regulatory systems that control ROBERTK. MORTIMER

Recipients of GSA Honors

Thomas Hunt Morgan Medal Genetics Society of America Medal 1981 Barbara McClintock,Marcus M. Rhoades 1981Beatrice Mintz 1982 Sewall Wright 1982 Gerald R. Fink 1983Edward B. Lewis 1983 Charles Yanofsky 1984 George W. Beadle, R. Alexander Brink 1984David S. Hogness 1985 Herschel L. Roman 1985Philip Leder 1986 Seymour Benzer 1986 Gerald M. Rubin 1987 James F. Crow 1987Sydney Brenner 1988 Norman H. Giles 1988David Botstein, Ira Herskowitz sll

REPORT ON THE GENETICS SOCIETY OF CANADA AWARDS

The GeneticsSociety of Canada hasin its mem- The YoungScientist Award was given forthe first bership over 500 scientists working in various aspects time in 1987. It was bestowed upon Arthur J. Hilliker of genetics research in university, government and of the Department ofBotany and Genetics atthe industrial laboratories. The Societybestows two University of Guelph for his contributions in studies awards annually. The 1987Award of Excellence was of intergenic recombination, gene reorganization, givento Etta Kafer of the Genetics Department of linkage group conservation and segregation distor- McGill University, Montreal, forher outstanding tionin Drosophila. contributions to the geneticsof filamentous fungi.

1987 Genetics Society of Canada Award of Excellence: Etta Kafer

Etta Kafer carried out her undergraduate studies basis for the discussion of the implication for such atthe UniversitC de Lausanne, Switzerland, then cycles in fungi, but also helped to provide the intel- received her Ph.D. from the UniversitatZurich in lectualbasis forthe development ofsomatic cell 1953, working with Professor E. Hadorn. She went genetics in humans. A second area of research is the to the University of Glasgow as a Nuffield research nature andbehavior of chromosome rearrangements fellow, and as a Carnegie research fellowto the and aneuploids in Aspergallus. This work has led to Carnegie Institute and to Cold Spring Harbor. In the development of a short-term eukaryotic test sys- 1958, she joined thestaff of the Genetics Department tem for the detection of environmental agents that at McGill, where she has been Molson Professor of cause aneuploidy. Morerecently she hasbecome Genetics since 1983. interested in molecular mechanisms of chromosome Etta Kafer is well known for her pioneering work behavior approached through thestudy of mutagen- on mitotic recombination and chromosome assort- sensitive mutants, firstat the genetic, then at the ment in Aspergillus. Her clear elucidation of the ge- molecular level. neticsof parasexual systemsnot only formedthe

1987 Genetics Society of Canada Young Scientist Award: Arthur J. Hilliker

Arthur J. Hilliker carried out his undergraduate During postdoctoral research atthe University of studies at the University of British Columbia, where Connecticut, he studied the region of the XDH gene, he studied with D. J. Holm and completed a Ph.D. using a series of point mutants and deletions that in Zoology in 1975. He was a postdoctoral fellow in identified the genetic elements adjacent to the gene the Department of Biology at the University of Con- and supported thehypothesis of one gene: one chro- necticut in the laboratory of Arthur Chovnik. He was momere. This gene system is now one of the best then a research scientist at the Commonwealth Sci- characterized simple loci in Drosophila and serves as entific and Industrial Research Organization in Can- a model for thegeneralized simple euchromatic gene. berra, Australia, from 1978-81. He joined the De- While in Australia, Hilliker applied his knowledge partment of Botany and Genetics at the University of chromosome mechanics, cytogenetics, and in situ of Guelph in 1982. hybridization to draw important conclusions regard- The common theme of the papers that are the ing theorganization of repetitious sequence elements basis for this award is the natureof gene organization within the heterochromatin of the X chromosome. in higher eukaryotes. Hilliker’s first major contribu- Sincejoining thefaculty at the University of Guelph, tion involved the identification of a series of unique he has studied the three-dimensional structure of the vital genes that were identified in heterochromatin. interphase nucleus. s12

REPORT OF THE TREASURER

The following is the unaudited financial statement for the fiscal year 1987. The audited statement will be available from the Administrative Office.

STATEMENT OF ASSETS AND FUND BALANCES ARISING FROM CASH TRANSACTIONS December 31, 1987

Assets Editor’s Office-CheckingIPetty Cash $ 1,997.63 Administrative Office-Checking 135,520.76 Cash on Hand 25.00 Bulk Mail Deposit 517.78 Total Cash $ 138,061.17

Merrill Lynch Cash Management Account $ 29,752.28 Certificates of Deposit: Matures 3/28/88; @ 12.0% 50,000.00 Matures 3/14/89; @ 12.05% 50,000.00 Matures 1/16/89; @ 10.9% 50,000.00 Matures 6/18/91; @ 8.3% 50,000.00 Matures 6/18/93; @ 8.5% 50,000.00 Matures 1/16/91; @ 7.9% 50,000.00 Matures 10/22/90; @ 7.4% 14,000.00 Matures 10/19/88; @ 8.5% 90,000.00 Franklin U.S. Government Securities Fund 278,674.45 Government Income Securities, Inc. 155,009.96 Securities: Bellsouth Corp.-600 shares 25,226.44 Heinz Corp.-400 shares 17,951.56 ADP, 1nc.-600 shares 28,545.50 Total Investments 939,160.19

Furniture and Equipment $ 35,419.60 Less: Accumulated Depreciation (13.018.70) Total Furniture and Equipment 22.400.90

Total Assets $1,099,622.26

Fund Balances General Fund Fund Balance at January 1st $898,901.55 Excess of Cash Receipts over Disbursements (49.279.29) General Fund Balance at December 31st $ 849,622.26

Reserve Fund Fund Balance at December 3 1st 250,000.00

Total Fund Balances-All Funds $1,099,622.26 s13 STATEMENT OF CASH RECEIPTS AND DISBURSEMENTS For the Year Ending December 31,1987

Cash Receipts Membership Income $138,466.33 Journal Sales 40 1,033.64 Publications 54,792.91 Yeast Travel Award Donations 1 1,800.00 1987 GSA Annual Meeting 52,645.00 1987 Yeast Genetics Meeting 74,326.00 ABMG Contractual Fee 17,572.50 Interest Income-Administrative Office 3,065.91 Interest Income-Investments 104,452.85 Dividend Income-Investments 43,737.64 Gain on Sale of Securities 19,482.77 Miscellaneous Income 364.50

Total Receipts 1,740.05 $92

Cash Disbursements Membership Expense $ 29,960.19 Journal Publishing 369,3 1 1.42 Publications Expense 51,126.55 Drosophila Expense 2,179.87 Yeast Awards and Expense 12,250.82 1987 GSA Annual Meeting 10 1,949.96 1987 Yeast Genetics Meeting 11 1,467.48 Awards and Fellowships 94,563.71 ABMG Contract Expense 16,854.74 Other Expense 65,62 1.38 Administrative Office 115,733.22

Total Disbursements 971.019.34

Excess of Cash ReceiDts Cash of Excess over Disbursements @ 49,279.291

ALLANC. SPRADLING,Treasurer s14

REPORT OF THE EDITOR

For 1987, GENETICS introduced a larger page size figures and tables in the new double-column format. and a monthly column of comment, Perspectives, both The number of submitted manuscripts increased by of which were well received. The number of pages 6% to 371. Note, however, that printed articles reflect of regular articles was 2,095 and of abstracts and submissionsover a much wider interval thanthe annualreports was 104 fora totalof 2,199. When calendar year.Paid circulation increased by 2.5%to corrected for the new1987 page size,this is 1% more 4740. than the 1986 total. The number of printed articles increased by 7.7%224, to more thanthe increase for JOHN W. DRAKE,Editor total pages because of improved page efficiency for

REPORT OF THE SECRETARY

The Genetics Society of AmericaBoard of Directors The next Board meeting will be held from 1:OO- met on June 13, 1987, at the San Francisco Hilton 6:OO p.m. on August 24, 1988, in Conference Room Hotel in conjunction with the Annual Meeting of the A of the Sheraton Centre Hotel, in connection with Society. The Board also met at the Lee Building on the XVI International Congress of Genetics in To- the FASEB campus on January 16, 1988. ronto. The awards ceremony will occur at a special The Society continues to growat a steady pace, reception on August 23 at 5:OO p.m. at the Sheraton with 2,419 regular, 188 emeritus, and 436 student Centre Hotel. members, and 22 affiliates for a total of 3,065 mem- berdaffiliates as of December 3 1, 1987.The category ANTHONYP. MAHOWALD,Secretary of affiliate was established atthe June 13, 1987, Board of Directors meeting.

1987 GRADUATE STUDENT TRAVEL AWARDS

For thethird year, the GeneticsSociety of America 1987, 60 students received awards of up to $600 conducted a competitive awards program to help each. The namesof the recipients follow. defray expenses of graduate students presenting papersthe at Annual Meeting. Graduatestudent BARRYS. GANETZKY,Chair travel awards mayusedbecover to the costof CATHYC. LAURIE,MAYNARD V. OLSON transportation, lodging, meals and registration. In

1987 Recipients Hassan Ashktorab Jian-Bing Fan Thomas Laz Fredric Rosenberg Mark Batzer Guy Farish Pung-Choo Lee John Salmeron Cynthia Bayer I. K. Farrance Janine Maddock P. E. Schwartz Lynn Bemis David Featherston Kiran Madura J. Andrew Shaw Paul Bentzen Karen Hahnenberger J. Ellen Marsden Nancy Shen Robert Booher R. Keith Hamby Janna McLean Brenda Shirley Kevin Brady Robert Hawley Barbara McLean Jae Song Anne Bullerjahn Ellen Heath Bruce McPheron Terry Starr Robin Bush Jeanne Hirsch H. Allen Orr William Strauss Denise Clark Tom Hobman Michael Pietro Ronald Susek Mary Davis Shelley Horne Kay Pleyte Craig Tepper Leslie DeLong Robert Johnson Laura Ranum Jan Trybula Angela DiBenedetto Monica Justice Christopher Roberts Shirley Wang Mercedes Ebbert Kenneth Koo Steven Robinow Charles Wilke Arri Eisen Philip Krasney Charles Romano Yan Zhu s15

1987 UNDERGRADUATE emy Thorner): Isolation of calcium channel mutants RESEARCH FELLOWSHIPS in Saccharomyces cerevisiae. Margaret Sun Leng Lee, (Dale Last year, 135 applicants competed for 25 under- Kaiser): Cloning the spoAIII developmental gene of graduate fellowships of $2,400 each to fund research M. xanthw. for aneight-week period during thesummer. Juniors, Malcolm Lippert, Hope College (James Gentile): Ac- or seniors in theirfourth year andintending to tivation of promutagens by the greenalga Selmmtrum attend graduate school after graduation were eligible capricornutum in the plant cell-microbe coincubation to apply. The sponsors in whose laboratory the assay. research was carried out were GSA members. Every effort was made to support students in diverse areas George Mallouk, UCLA (Richard Weiss): Cloning of of genetics and in a variety of institutions. Names thestructural gene for arginase from Neurospora and affiliations of award recipients, their sponsors’ crassa. names, and the titles of their research projects are CeciliaMoens, York University (B. W. Glickman): listed below. Mutational mechanism of benzo[a]pyrene in the LacZ RAY D. OWEN,Chair gene of E. coli. FRANKLINW. STAHL,MARIANA F. WOLFNER John Oblong, Loyola University of Chicago(Howard 1987 Recipients Laten): Enzymeactivity of cytokinin synthesis in Saccharomyces cerevisiae. Eric Bain, (Edward C. Cox): Separation ofcbromosome-sized DNA molecules Amanda Paulovich, Carnegie MellonUniversity from P. pallzdum by pulsed-field gel electrophoresis. (John Woolford): Isolation of mutant alleles of the Saccharomyces cerevisiae CRY1 gene encoding ribo- Richard Bernstein, Cornell University (Stanley Zah- somal protein 59. ler): Construction and use of a new Tn9 17-lac2 fusion transposon. RobinRingley, Duke University (Craig Giroux): Retroposon mutagenesis and gene cloning in yeast: Andrea Bonny, Universityof Notre Dame(Mary meiosis specific genes. Clancy): Isolation of meiotic mutants of yeast. Janet Rosenthal, Cornell University (Thomas Fox): Richard Chin, (Fotis Kafatos): A Regulation of the yeast mitochondrial gene for cyto- linker scanner experiment on the promotor of the chrome oxidase subunit I1 by the nuclear gene developmentally regulated chorion gene pair A/ PET1 12. BL.12 of the silkmoth Bombyx mori. Robert Schroetke, University of Colorado, Colorado Claire DeLeo,Villanova University (R. William Springs (James Mattoon): The effects of mutant RAS- Marks): Sperm use patterns in multiply mated female oncogenes on mitochondrial biosynthesis in yeast. . David Stern, Cornell University (Charles Aquadro): SarahGaffen, Carnegie MellonUniversity (Steven Molecular and phenotypic variation atthe period Scholnick):Zn vitro mutagenesis of the Drosophila dopa locus within and between populations of Drosophila decarboxylase gene. melanogaster and D. simulans. Susan Glass, Duke University (Sharyn Endow): Anal- Elaine Sugarman, Brandeis University (James ysis of the ribosomal genes of diploid Drosophila tissue Haber): Gene conversion and crossing-over created containing the Ybb-rev ribosomal gene . by an HO induced double-strand break. David Higgs, University of Minnesota (Ronald Phil- Herman Tampe, CatholicUniversity (John Golin): lips): The effect of heterochromatic knobs on maize Mitotic recombination in yeast. tissue culture variability. Marc Jacobs, Stanford University (Ward Watt): Study Elly Tanaka, Harvard UniversityIRadcliffeCollege of natural selection on polygenic variation in the wild. (Lawrence Goldstein): A genetic and molecular anal- ysis of the 205K microtubule-associated protein gene Bryan Julien, (Mark Levinthal): in Drosophila. Genetic and biochemical analysis of threonine non- utilizing (Tuc-) mutants of E. coli. Rabiya Tuma, Universityof California, Berkeley (Kathryn Anderson): Genetic and molecular analysis Peggy Kolm, University of California, Berkeley (Jer- of a group of dysgenic revertants of the TI 84c allele.