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Cold Spring Harbor Symposia on Quantitative Biology COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLV---PART 1 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLV MOVABLE GENETIC ELEMENTS COLD SPRING HARBOR LABORATORY 1981 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME XLV 1981 by The Cold Spring Harbor Laboratory International Standard Book Number 0-87969-044-5 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANT1TA T1VE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena XXIII (1958) Exchange of Genetic Material: Mechanism I1 (1934) Aspects of Growth and Consequences Ili (1935) Photochemical Reactions XX1V (1959) Genetics and Twentieth Century Darwinism IV (1936) Excitation Phenomena XXV (1960) Biological Clocks V (1937) Internal Secretions XXV1 (I 961) Cellular Regulatory Mechanisms VI (1938) Protein Chemistry XXVll (1962) Basic Mechanisms in Animal Virus Biology VII (1939) Biological Oxidations XXVIlI (1963) Synthesis and Structure of Macromolecules VIII (1940) Permeability and the Nature of Cell Mem- XXIX (1964) Human Genetics branes XXX (1965) Sensory Receptors 1X (1941) Genes and Chromosomes: Structure and Organi- XXXI (1966) The Genetic Code zation XXXII (1967) Antibodies X (1942) The Relation of Hormones to Development XXXIlI (1968) Replication of DNA in Microorganisms XI (1946) Heredity and Variation in Microorganisms. XXX1V (1969) The Mechanism of Protein Synthesis XII (1947) Nucleic Acids and Nucleoproteins XXXV (1970) Transcription of Genetic Material XIII (1948) Biological Applications of Tracer Elements XXXVI (1971) Structure and Function of Proteins at the XIV (1949) Amino Acids and Proteins Three-dimensional Level XV (1950) Origin and Evolution of Man XXXVI1 (1972) The Mechanism of Muscle Contraction XVI (1951) Genes and Mutations XXXVIll (1973) Chromosome Structure and Function XVII (1952) The Neuron XXXIX (1974) Tumor Viruses XVIII (1953) Viruses XL (1975) The Synapse XIX (1954) The Mammalian Fetus: Physiological Aspects XLI (1976) Origins of Lymphocyte Diversity of Development XLll (1977) Chromatin XX (1955) Population Genetics: The Nature and Causes of XLIII (1978) DNA: Replication and Recombination Genetic Variability in Population XL1V (1979) Viral Oncogenes XXI (1956) Genetic Mechanisms: Structure and Function XXII (1957) Population Studies: Animal Ecology and De- mography The Symposium Volumes are published by The Cold Spring Harbor Laboratory, Box 100, Cold Spring Harbor, New York 11724. Symposium Participants ABou-SABE, MORAD A., Dept. of Microbiology, BESEMER, JURGEN, Dept. of Genetics, University of Rutgers University, New Brunswick, New Jersey K61n, Federal Republic of Germany AnMED, ASAD, Dept. of Genetics, University of Al- BIEK, DONALD, Dept. of Biology, University of Utah, berta, Edmonton, Canada Salt Lake City ANISIMOV, P. I., Antiplague Research Institute, Saratov, BIEZUNSKI, NAOMI, Dept. of Biology, Case Western USSR Reserve University, Cleveland, Ohio APPLEBY, DAVID, Institute of Toxicology, Albany Medi- BINGHAM, PAUL, NIEHS, National Institutes of Health, cal College, New York Research Triangle Park, North Carolina APPLEBY, NORMA, Institute of Toxicology, Albany BIRSHTEN, BARBARA,Dept. of Cell Biology, Albert Ein- Medical College, New York stein College of Medicine, Bronx, New York ARBER, WEANER, Biozentrum, University of Basel, BLAKESLEY, ROBERT, Bethesda Research Laboratories, Switzerland Inc., Rockville, Maryland ARNHEIM, NORMAN, Dept. of Biochemistry, State Uni- BLOCK, KARIN, Institute of Genetics, University of versity of New York, Stony Brook Lund, Sweden ATK1NS, JOHN F., Dept. of Biology, University of Utah, BOCCARA, MARTINE, INSERM, Pasteur Institute, Lille, Salt Lake City France AUERSWALD, E. A., Dept. of Microbiology, University BOISTARD,PIERRE, Dept. of Vegetable Pathology, Insti- of Heidelberg, Federal Republic of Germany rut National de la Recherche Agronomique, Ver- AUGUSTINE, ANDREI, Dept. of Microbiology, Columbia sailles, France University College of Physicians and Surgeons, BOAST, P1ET, Dept. of Biochemistry, University of Am- New York, New York sterdam, Holland AUSUBEL, FREDERICK, The Biological Laboratories, BOTCHAN, MICHAEL, Dept. of Molecular Biology, Uni- Harvard University, Cambridge, Massachusetts versity of California, Berkeley BABCOCK, MARLA, D-2 Carolina Apts., Carrboro, BOTSTEIN, DAVID, Dept. of Biology, Massachusetts In- North Carolina stitute of Technology, Cambridge BADE, ERNESTO, Faculty of Biology, University of BOURRET, ROBERT, Dept. of Biology, Massachusetts Konstanz, Federal Republic of Germany Institute of Technology, Cambridge BAKER, ROBERT, Dept. of Molecular Biology, Univer- BRENNER, SYDNEY, Laboratory of Molecular Biology, sity of Southern California, Los Angeles Medical Research Council, Cambridge, England BALTIMORE, DAVID, Dept. of Cancer Research, Massa- BROREIN, WILLIAM, JR., 1199 Beacon St., Brookline, chusetts Institute of Technology, Cambridge Massachusetts BANK, ARTHUR,Hammer Health Sciences Center, Co- BUKHARI, AHMAD I., Cold Spring Harbor Laboratory, lumbia University, New York, New York New York BEDBROOK, J. R., Plant Industry Division, CSIRO, BURR, BENJAMIN, Dept. of Biology, Brookhaven Na- Canberra, Australia tional Laboratory, Upton, New York BENNETT, P. M., Dept. of Bacteriology, University of BURTON, WILLIAM, Bethesda Research Laboratories, Bristol, England Inc., Rockville, Maryland BENSON, SPENCER, Dept. of Cancer Biology, Frederick CABEZON, TERESA, Smith Kline-RIT, Rixensart, Bel- Cancer Research Center, Frederick, Maryland gium BERG, CLAIREM., Dept. of Biological Sciences, Univer- CAIRNS, JOHN, Imperial Cancer Research Fund Labo- sity of Connecticut, Storrs ratories, London, England BERG, DOUGLAS, Dept. of Microbiology, Washington CALOS, MICHELE, Dept. of Molecular Biology, Univer- University Medical School, St. Louis, Missouri sity of Geneva, Switzerland BERNARDI, ALBERTO,Genetics Center, CNRS, Gif-sur- CAMPBELL, ALLAN M., Dept. of Biological Sciences, Yvette, France Stanford University, California BERNINGER, MARK, Bethesda Research Laboratories, CANNON, FRANK,ARC Unit of Nitrogen Fixation, Uni- Inc., Rockville, Maryland versity of Sussex, Brighton, England BERTANI, G1USEPPE, Dept. of Microbial Genetics, CARDILLO, THOMAS, Dept. of Radiation Biology and Karolinska Institute, Stockholm, Sweden Biophysics, University of Rochester, New York BERTRAND, KEV1N, Dept. of Microbiology, University CARLSON, MAR1AN, Dept. of Biology, Massachusetts of California, Irvine Institute of Technology, Cambridge vi SYMPOSIUM PARTICIPANTS CASADABAN,MALCOLM, Dept. of Biophysics and Theo- EMERICK, ANNE, Cetus Corporation, Berkeley, Califor- retical Biology, University of Chicago, Illinois nia CASEY, JAMES, Dept. of Chemistry, California Institute ENDOW, SHARYN,Dept. of Microbiology and Immunol- of Technology, Pasadena ogy, Duke University Medical Center, Durham, CHACONAS, GEORGE, Cold Spring Harbor Laboratory, North Carolina New York ENGELS, WILLIAM, Dept. of Genetics, University of CHANDLER, MICHAEL, Dept. of Molecular Biology, Wisconsin, Madison University of Geneva, Switzerland ERNST, JOACHIM, Dept. of Radiological Biology and CHATTORAJ, DHRUBA,NICHHD, National Institutes of Biophysics, University of Rochester, New York Health, Bethesda, Maryland ERREDE, BEVERLY, Dept. of Radiation Biology and CLOWES, ROYSTON, Dept. of Biology, University of Biophysics, University of Rochester, New York Texas at Dallas, Richardson FALLEN, MICHAEL, Dept. of Genetics, Universit6 Libre COHEN, S. N., Dept. of Genetics, Stanford University de Bruxelles, Rhode-St.-Gen~se, Belgium School of Medicine, California FARABAUGH, PHILIP, Dept. of Biochemistry, Cornell COLLINS, JOHN, Gessellschaft Biotechnologische fur University, Ithaca, New York Schungsstehle, Braunschweig, Federal Republic of FASY, THOMAS M., Dept. of Pathology, Mt. Sinai Germany School of Medicine, New York, New York COMEAU, ANNE M., Dept. of Biology, Brandeis Univer- FEDOROFF, NINA, Dept. of Embryology, Carnegie In- sity, Waltham, Massachusetts stitution of Washington, Baltimore, Maryland CORNELIS, GUY, Dept. of Microbiology, Catholic Uni- FEINGOLD, JAY, Dept. of Molecular Biology, Albert versity of Louvain, Brussels, Belgium Einstein College of Medicine, Bronx, New York COZZARELLI, NICHOLAS, Dept. of Biochemistry, Uni- FENNEWALD, MICHAEL, Dept. of Biochemistry, Univer- versity of Chicago, Illinois sity of Chicago, Illinois CROW, JAMES F., Dept. of Genetics, University of Wis- FINCHAM, JOHN R. S., Dept. of Genetics, University of consin, Madison Edinburgh, Scotland DATTA, NAOMI, Hammersmith Hospital, Royal Post- FINK, GERALD, Cornell University, Ithaca, New York graduate Medical School, London, England FLAVELL, ANDREW, Sidney Farber Cancer Institute, DAvis, MARK M., California Institute of Technology, Boston, Massachusetts Pasadena FLAVELL, RICHARD B., Plant Breeding Institute, Cam- DAVlSON, JOHN, Institute of Cell Pathology, Brussels, bridge, England Belgium FLEISSNER, ERW1N, Sloan-Kettering Institute for DE BRUIJN,FRANS J., The Biological Laboratories, Har- Cancer Research, New York, New York vard University, Cambridge, Massachusetts FLYNN, ANN E., New England Biological Laboratories, DECARIS, BERNARD, Dept. of Genetics, University of Inc., Beverly, Massachusetts Paris, Orsay, France FOSTER, T. J., Dept. of Microbiology, Trinity College, DE CROMBRUGGHE,BENOIT, NCI, National Institutes of Dublin, Ireland Health, Bethesda, Maryland
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