Supernus Prescribing Information & Patient Information

FOR PARKINSON’S DISEASE What is XADAGO?

XADAGO (saﬁnamide) is a prescription medicine known as a monoamine oxidase type B WHERE WILL YOU (MAO-B) inhibitor used with levodopa/carbidopa to treat adults with Parkinson’s disease (PD) who are having off episodes. XADAGO NEXT? XADAGO has not been shown to be effective to treat PD when taken as a single medicine (monotherapy).

XADAGO can help increase your on time and decrease your off time1

Important Safety Information Tell your physician if you are taking, or planning to take, any prescription or over-the-counter drugs. Do not take XADAGO if you are taking other monoamine oxidase inhibitors (MAOIs), as it could cause a sudden severe increase in your blood pressure.

® The combination of MAO-B inhibitors such as XADAGO and antidepressants has resulted in a serious and XADAGO can increase your daily on time sometimes fatal condition called serotonin syndrome. without troublesome dyskinesia1 (saﬁnamide) tablets 2

Please see the complete Important Safety Information on pages 12-13 and Please see the complete Important Safety Information on pages 12-13 the accompanying full Prescribing Information and Patient Information. and the accompanying full Prescribing Information and Patient Information. What is ON and OFF time? What is “good” ON time?

During a typical day, you experience on and off time.2 “Good” on time is when you don’t experience troublesome dyskinesia. As you experience diminishing beneﬁts of levodopa/carbidopa over time, it’s important to have “good” on time each day.2-4

• Your PD symptoms are at a minimum ON OFF Troublesome Dyskinesia is when: • Your oral levodopa/carbidopa medication is working well • Uncontrollable (involuntary), abnormal movements interfere with your daily activities ON TIME • You are moving and able to go about your day —even during on time5 • These abnormal movements often occur as a side effect of long-term treatment with levodopa/carbidopa6 • Examples of dyskinesia include fidgeting, writhing or wriggling, head bobbing, and • Your PD symptoms have re-emerged and are at body swaying7 or near their worst ON OFF • Your oral levodopa/carbidopa medication isn’t working well OFF TIME • Symptoms like stiffness (rigidity), freezing, shaking (tremor), (or off episodes) slowness, cramping, difficulty moving, shuffling, low voice, and loss of facial expression re-emerge

Important Safety Information Do not take XADAGO with opioid medications including meperidine, tramadol, methadone, or propoxyphene, as this could result in serious, sometimes fatal, reactions. Also, do not take XADAGO with amphetamine, cyclobenzaprine, methylphenidate, or St. John’s wort. Taking these drugs together can also result in serotonin syndrome, which could be fatal. Do not use XADAGO with dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior.

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® WHERE WILL YOU Please see the complete Important Safety Information on pages 12-13 XADAGO NEXT? (saﬁnamide) tablets and the accompanying full Prescribing Information and Patient Information. How can XADAGO help me? What can I expect when taking XADAGO?

XADAGO can increase your daily on time without troublesome dyskinesia and can help XADAGO can give you lasting on time without troublesome dyskinesia. Clinical trials showed that reduce your off time.3 patients taking once-daily XADAGO1:

• Saw improvements in their ability to move and take on their day as early as 2 to 4 weeks • Maintained those improvements over time without troublesome dyskinesia Studied In Over Patients

Clinical trials showed that once-daily XADAGO can3: • Increase daily on time—without troublesome dyskinesia XADAGO patients reported • Reduce off time and off time symptoms signiﬁcant improvements in their • Help improve your ability to move and take on your day health status at 6 months2,3*

Get more on time—up to 1 hour

*As assessed by the Parkinson’s Disease Questionnaire (PDQ-39), a PD-speciﬁc health status questionnaire. Results are based on the 100 mg/day dose of XADAGO.8

Important Safety Information Do not use XADAGO if you have hypersensitivity to saﬁnamide, as this can cause swelling of the tongue and mouth and trouble breathing. The most common side effects seen with XADAGO are uncontrolled movements (dyskinesia), falls, nausea, and insomnia.

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® WHERE WILL YOU Please see the complete Important Safety Information on pages 12-13 XADAGO NEXT? (saﬁnamide) tablets and the accompanying full Prescribing Information and Patient Information. What can I expect when taking XADAGO?* How does XADAGO Work?

During clinical trials, physicians reported that XADAGO, when added to levodopa/carbidopa, helped MAO-B is a substance that naturally breaks down chemicals in your brain, like dopamine. Too little control PD motor symptoms such as3,9: dopamine in your brain can cause impaired movement and PD motor symptoms like stiffness (rigidity), freezing, and shaking (tremor).1

More abilty to speak Less shaking (tremor)

XADAGO helps block MAO-B from Normal breaking down dopamine in your brain.1

With PD Dopamine More freedom of Less stiffness (rigidity) facial expression

Adding XADAGO to levodopa/carbidopa increases dopamine levels by preserving your body’s dopamine, as well as dopamine made from levodopa, at all stages of PD.

Improved balance Less slowed movement (bradykinesia)

Important Safety Information During treatment with XADAGO you may experience increases in blood pressure. Inform your physician if you have a history of high blood pressure. Possible symptoms of an unsafe rise in blood pressure include severe headache, blurred vision, confusion, seizures, shortness of breath, severe anxiety, and nausea and vomiting. *As assessed by the UPDRS III scale. Contact your doctor or seek immediate medical attention if you experience any of these symptoms.

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® WHERE WILL YOU Please see the complete Important Safety Information on pages 12-13 XADAGO NEXT? (saﬁnamide) tablets and the accompanying full Prescribing Information and Patient Information. How do I take XADAGO? What are the possible side effects of XADAGO?

Take XADAGO once daily in addition to your levodopa/carbidopa.1 Before taking XADAGO, tell your healthcare provider about all the medications and supplements you are taking.1 • XADAGO can be taken at any time of the day, with or without food1 While taking XADAGO, discuss with your healthcare provider any medications you may 1 • Over 87% of patients in clinical trials did not require a change in their levodopa dose2,3 consider starting. — XADAGO was simply added on! Most common side effects when taking XADAGO include1: • Uncontrolled, sudden movements (dyskinesia) • Falls • Nausea • Trouble falling asleep or sleeping (insomnia)

Restriction of foods and beverages containing tyramine is usually not required when treated with the recommended doses of XADAGO. However, it is recommended that you avoid foods containing high amounts of tyramine, such as aged cheeses, as some patients may have an increased sensitivity that could lead to an unsafe rise in blood pressure. All PD patients should be monitored for hallucinations, impulse control, and confusion. 50 mg* The recommended starting dose of XADAGO is 50 mg once daily

100 mg* After 2 weeks, your healthcare provider may decide to increase your daily dose to 100 mg once daily, if necessary

*Images above are not actual size of XADAGO tablets

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® WHERE WILL YOU Please see the complete Important Safety Information on pages 12-13 XADAGO NEXT? (saﬁnamide) tablets and the accompanying full Prescribing Information and Patient Information. Are there ﬁnancial assistance programs available? Important Safety Information

The XADAGO Prescription Savings Program helps eligible patients save on their XADAGO Indication prescriptions. With the program you can receive automatic savings at over 67,000 pharmacies— XADAGO is a prescription medicine known as a monoamine oxidase type B (MAO-B) inhibitor. no card needed! XADAGO is used with levodopa/carbidopa to treat adults with PD who are having off episodes. Limitations of Use XADAGO has not been shown to be effective to treat PD when taken as a single medicine (monotherapy). Pay Rx Important Safety Information for Patients as little as $25* Tell your physician if you are taking, or planning to take, any prescription or over-the-counter drugs. (save up to $125) • Do not take XADAGO if you are taking other monoamine oxidase inhibitors (MAOIs), on your XADAGO prescription each month as it could cause a sudden severe increase in your blood pressure. • The combination of MAO-B inhibitors such as XADAGO and antidepressants has resulted in a serious and sometimes fatal condition called serotonin syndrome. If you cannot afford your medication there are programs that may be able to help. • Do not take XADAGO with opioid medications including meperidine, tramadol, methadone, or propoxyphene, as this could result in serious, sometimes fatal, reactions. Call 1-888-4XADAGO, Option 3, to learn more. • Also, do not take XADAGO with amphetamine, cyclobenzaprine, methylphenidate, or St. John’s wort. Taking these drugs together can also result in serotonin syndrome, which could be fatal. Visit XADAGO.com to learn more • Do not use XADAGO with dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior. Do not use XADAGO if you have hypersensitivity to saﬁnamide, as this can cause swelling of the tongue and mouth and trouble breathing. You should not take XADAGO if you have severe liver disease. Do not exceed a dose of 50 mg per day of XADAGO if you have moderate liver disease. During treatment with XADAGO you may experience increases in blood pressure. Inform your physician if you have a history of high blood pressure. Possible symptoms of an unsafe rise in blood pressure include severe headache, blurred vision, confusion, seizures, shortness of breath, severe * Patients whose prescriptions will be paid for in part or in whole by Medicare, Medicaid, or any similar federal or state healthcare program, are not anxiety, and nausea and vomiting. Contact your doctor or seek immediate medical attention if you eligible for savings or rebates according to federal and state law. The actual savings on your out-of-pocket costs for XADAGO will vary according to reﬁll quantity, personal healthcare insurance coverage, and adherence to FDA dosing guidelines. experience any of these symptoms.

11 12 Please see the complete Important Safety Information on pages 12-13 and ® theWHERE accompanying WILL full Prescribing YOU Information and Patient Information. Please see the accompanying full Prescribing Information and Patient Information. XADAGO NEXT? (saﬁnamide) tablets Notes

Some patients treated with XADAGO experienced drowsiness or sudden onset of sleep. Do not drive, operate heavy machinery, work in high places or do other dangerous activities until you know how XADAGO affects you. Restriction of foods and beverages containing tyramine is usually not required when treated with the recommended doses of XADAGO. However, it is recommended that you avoid foods containing high amounts of tyramine, such as aged cheeses, as some patients may have an increased sensitivity that could lead to an unsafe rise in blood pressure. All PD patients should be monitored for hallucinations, impulse control and confusion. The most common side effects seen with XADAGO are uncontrolled movements (dyskinesia), falls, nausea, and insomnia. It is not known if XADAGO is safe and effective in children. To report SUSPECTED ADVERSE REACTIONS or product complaints, contact US WorldMeds at 1-888-492-3246 (1-888-4XADAGO). You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Please see the accompanying full Prescribing Information and Patient Information.

References 1. XADAGO Full Prescribing Information. Louisville, KY: US WorldMeds; 2017. 2. Schapira AHV, Fox SH, Hauser RA, et al. Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol. 2017;74(2):216-224. 3. Borgohain R, Szasz J, Stanzione P, et al. Randomized trial of safinamide add-on to levodopa in Parkinson’s disease with motor fluctuations. Mov Disord. 2014;29(2):229-237. 4. Jankovic J. Motor fluctuations and dyskinesias in Parkinson’s disease: clinical manifestations. Mov Disord. 2005;20(Suppl 11):S11-S16. 5. U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke. (2014). Parkinson’s Disease: Hope Through Research (NIH Publication No. 15-139). Bethesda, MD: U.S. Government Printing Office. 6. Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson’s disease. Neurology. 2009;72(Suppl 4):S1-S136. 7. Dyskinesia. The Michael J. Fox Foundation for Parkinson’s Research. https://www.michaeljfox. org/understanding-parkinsons/living-with-pd/topic.php?dyskinesia. Last accessed April 12, 2018. 8. Jenkinson C, Fitzpatrick R, Peto V, et al. The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing. 1997;26(5):353-357. 9. Data on file. Louisville, KY: US WorldMeds; 2017.

WHERE WILL YOU XADAGO NEXT?

Once-daily XADAGO can3: • P rovide more daily on time— without troublesome dyskinesia • R educe the amount of off time that you experience during the day • I mprove your ability to move and take on your day

Visit XADAGO.com to learn more

Please see the complete Important Safety Information on pages 12-13 and the accompanying full Prescribing Information and Patient Information.

TM ®

Under License from Newron Pharmaceuticals SpA. ® US WorldMeds, LLC is the exclusive licensee and distributor of XADAGO in the United States and Its territories. WHERE WILL YOU ©2018. Zambon SpA. XADAGO is a registered trademark of Zambon SpA. USWM-XAD122-0418 (saﬁnamide) tablets XADAGO NEXT? (saﬁnamide) tablets IS MYOBLOC RIGHT FOR YOU?

What is sialorrhea?

Sialorrhea, more commonly known as drooling, is the medical term for an excess spillage of saliva from the mouth. It is a common symptom in certain neuro- DOES EXCESSIVE SALIVA OR degenerative diseases, such as Parkinson’s disease (PD).1 Chronic sialorrhea DROOLING NEGATIVELY AFFECT is when you’ve experienced this drooling for at least 3 months. Sialorrhea can affect up to 3 out of 4 YOUR EVERYDAY LIFE? patients with PD1

In many patients with sialorrhea, it’s not that their salivary glands are making too much saliva — it’s that their neurodegenerative disease, such as PD, makes it hard to swallow. The saliva builds up or “pools” in the mouth, which leads to drooling.

Sialorrhea can make many aspects of daily life more challenging.1

Speaking Eating Social Interaction Up to 77% of patients feel social and emotional effects of drooling1

Sialorrhea can also have physical consequences, including2: • Chapped lips, irritated skin around the mouth, and oral hygiene issues • Sleep problems and increased tiredness • Respiratory infections, such as pneumonia, and breathing problems How can MYOBLOC help?

MYOBLOC is a proven and effective treatment for adults who suffer from chronic sialorrhea. MYOBLOC works to disable a protein that would typically trigger the release of excessive acetylcholine (a chemical released by nerve cells) near the salivary glands. As a result, the glands produce less saliva.

*Actor Portrayal MYOBLOC can decrease symptoms of chronic sialorrhea in as little as 1 week and can last up to 3 months.3,4

By reducing these symptoms, you may feel more confident in your everyday life. MYOBLOC is indicated for the treatment of chronic sialorrhea in adults. Please see Important Safety Information on the back page and accompanying full Please see Important Safety Information on the back page and accompanying full Prescribing Information, Prescribing Information, including Boxed WARNING and Medication Guide. including Boxed WARNING and Medication Guide. Is MYOBLOC right for you? Review the questions about sialorrhea below: *Actor Portrayal

Does saliva dribble in the corner of your mouth Q Yes Q No during the day? IMPORTANT SAFETY INFORMATION (continued) MYOBLOC is a prescription medicine used in adults that is injected into: Does your pillow or bedding get wet from drooling Q Yes Q No • Muscles and used to treat the abnormal head position and neck pain that happens with cervical dystonia (CD) • Glands that make saliva and is used to treat long-lasting (chronic) drooling (sialorrhea) while you sleep? Do not receive MYOBLOC if you: are allergic to MYOBLOC or any of its ingredients (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as BOTOX® or BOTOX® Cosmetic, Does your clothing get wet from drooling during Q Yes Q No DYSPORT® , or XEOMIN® ; have a skin infection at the planned injection site. the day? Tell your doctor about all your medical conditions, including if you have: a disease that affects your muscles or nerves (such as ALS or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome); had any side effect from any botulinum toxin product in the past; a breathing problem, such as asthma or emphysema; a history of Do you carry tissues or a handkerchief in case you Q Yes Q No swallowing problems or aspiration; bleeding problems; drooping eyelids; plans to have surgery; had surgery on need to wipe away saliva? your face. Tell your doctor if you: are pregnant or plan to become pregnant (it is not known if MYOBLOC can harm your unborn baby); are breastfeeding or plan to breastfeed (it is not known if MYOBLOC passes into breast milk). Do you experience chronic cough? Q Yes Q No Tell your doctor about all medicines you take, including: prescription and over-the-counter medicines, vitamins, and herbal supplements. Using MYOBLOC with certain other medicines may cause serious side effects. Do not Do you ever feel embarrassed or self-conscious Q Yes Q No start any new medicines until you have told your doctor that you have received MYOBLOC in the past. about excess saliva or drooling? Especially tell your doctor if you: received any other botulinum toxin product in the last 4 months; received injections of botulinum toxin such as BOTOX® or BOTOX® Cosmetic, DYSPORT®, or XEOMIN® in the past (tell your doctor exactly which product you received); recently received an antibiotic injection; take muscle relaxants; take If you answered Yes to any of these questions, allergy or cold medicines; take sleep medicine. MYOBLOC can cause serious side effects, including allergic reactions. Symptoms of allergic reaction may include: itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint. Tell your doctor or get MYOBLOC may be right for you. medical help right away if you get wheezing, or trouble breathing, or if you get dizzy or faint. Other side effects of MYOBLOC include: • Cervical Dystonia: dry mouth, trouble swallowing, injection site discomfort or pain, headache Ask your doctor how MYOBLOC can help! • Sialorrhea: dry mouth, trouble swallowing For more information, refer to the Medication Guide or talk with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. IMPORTANT SAFETY INFORMATION Visit www.fda.gov/medwatch or call 1-800-FDA-1088. MYOBLOC® may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to weeks) after treatment with MYOBLOC: REFERENCES: 1. Leibner J, Ramjit A, Sedig L, Dai Y, Wu SS, Jacobsen C, et al. The impact of and the factors associated with drooling in Parkinson’s diseases. Parkinsonism Relat Disord. 2010;16(7):475–477. 2. Data on file. Solstice Neurosciences, LLC; Louisville, KY: • Problems swallowing, speaking, or breathing if the muscles that you use to breathe and swallow become 2019. 3. MYOBLOC® US Prescribing Information. Solstice Neurosciences, LLC; Louisville, KY: 2019. 4. Chinnapongse R, Gullo K, Nemeth P, Zhang Y, Griggs L. Safety and efficacy of botulinum toxin type B for treatment of sialorrhea in Parkinson’s disease: a prospective weak after the injection. Death can happen as a complication if you have severe problems with swallowing or double-blind trial. Mov Disord. 2012;27(2):219–226. breathing after treatment with MYOBLOC. • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with MYOBLOC. • Swallowing problems may last for several months. People who cannot swallow well may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving MYOBLOC have the highest risk of getting these problems. • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism myobloc.com include loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping MYOBLOC is a registered trademark of Solstice Neurosciences, LLC, a wholly-owned subsidiary of US WorldMeds, LLC. eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of All trademarks are the property of their respective owners. bladder control, trouble breathing, trouble swallowing (dysphagia). ©2019 US WorldMeds, LLC. USWMMYO-00037 09/19 Is APOKYN Right for You?

How can APOKYN help me? rapid. reliable. robust. APOKYN is a treatment that can be used along with your other PD medications, to rapidly and reliably provide oral levodopa-like effects, turning off time into Do you plan your day around your on time.2,3 Parkinson’s disease (PD) symptoms? Over time with oral levodopa medications, many patients start experiencing decreased “on” time and may be having what are known as “off episodes.” Off episodes are common and can happen at any time!4,5

You’re not alone — more than 350,000 people with PD experience off episodes1 Being on (or on time) is when: • Your oral levodopa medication is working well • Your PD symptoms are at a minimum • You are moving and able to go about your daily activities Start a conversation – talk to your doctor today

Off episodes (or off times) are when: • Your oral levodopa medication doesn’t work like it should and it’s not time for your next dose • The effects of your oral levodopa6,7: – Take a long time to work, especially in the morning – Don’t seem to work at all – Suddenly stop working and become unpredictable

• Your PD symptoms interrupt and interfere with your day to day life8 – Symptoms like tremor, slowness, stiffness, difficulty moving or walking and trouble getting around re-emerge – This may cause you to avoid certain activities8

Indication APOKYN is used by injection, as needed, to treat loss of control of body movements in people with advanced Parkinson’s disease (PD). This condition is also called hypomobility or off episodes. An off episode may include symptoms such as muscle stiffness, slow movements, and difficulty starting movements. APOKYN may improve your ability to control your movements when it is used during an off episode. Please see the Important Safety Information on back page and the accompanying This may help you walk, talk, or move around easier. APOKYN is not used to prevent full Prescribing Information and Pen Instructions for Use/Patient Information. off episodes. APOKYN does not take the place of your other medicines for PD.

*Actor Portrayal Important Safety Information for Patients

® Do not take APOKYN if you are being treated with certain drugs called 5HT3 antagonists (including Anzemet , rapid. reliable. robust. Kytril®, Zofran®, Lotronex®, and Aloxi®) that are used for nausea and vomiting or irritable bowel syndrome. People taking these types of drugs with APOKYN experienced severely low blood pressure and lost consciousness or “blacked out.” Do not take APOKYN if you are allergic to APOKYN or its ingredients, notably sodium metabisulfite. Sulfites can Review the questions below to see if APOKYN is right for you: cause severe, life-threatening allergic reactions in some people, especially in people with asthma. Before taking APOKYN, tell your healthcare provider about all your medical conditions, including if you have dizziness, fainting spells, low blood pressure, asthma, liver problems, kidney problems, heart problems, a mental disorder called 1. Do you have difficulty getting started in the morning because your major psychotic disorder, have had a stroke or other brain problems, or drink alcohol. oral levodopa medication takes a long time to work? Tell your healthcare provider about all medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements, because APOKYN may interact with other medicines causing serious side effects. Yes No APOKYN must be injected just under the skin and not into a vein. Injecting APOKYN into a vein could cause a blood clot. 2. Are there times when your oral levodopa medication takes too long Your healthcare provider may prescribe a medicine called Tigan® (trimethobenzamide hydrochloride) to help prevent to work, or sometimes doesn’t seem to work at all? the severe nausea and vomiting that may occur when taking APOKYN. If Tigan is prescribed, your healthcare provider will determine how long you should remain on this medicine. Yes No Some patients taking APOKYN may get sleepy during the day or fall asleep without warning doing everyday activities. Do not take medicines that make you sleepy while you are taking APOKYN. Until it is known how APOKYN 3. Are there times when your oral levodopa medication suddenly stops affects your ability to stay alert, you should not drive a car or operate heavy machinery. APOKYN may lower blood pressure and cause dizziness and fainting, especially when starting treatment or if the working or becomes unpredictable? dose is increased. Alcohol, antihypertensives, and nitrates may increase this risk. Patients should not get up too fast from sitting or after lying down to minimize these problems. Do not drink alcohol while you are using APOKYN. Yes No If you take nitroglycerin under your tongue while using APOKYN, your blood pressure may decrease and cause dizziness. Lie down and try to avoid standing for at least 45 minutes after taking nitroglycerin. 4. Do you avoid activities or schedule activities (errands, shopping, etc.) The changes that occur with PD and the effects of some PD medicines can increase the risk of falling. APOKYN can around off times or anticipated off times? also increase this risk. APOKYN can cause or worsen psychotic-like behavior including hallucinations (seeing or hearing things that are not Yes No real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking. Call your healthcare provider right away if you experience any of these symptoms. 5. Are there times you feel self-conscious or embarrassed about your Some people with PD may get sudden, uncontrolled movements (dyskinesias) after treatment with some PD off times? medicines. APOKYN can cause or worsen this effect. Some people with PD have reported new or increased gambling urges, increased sexual urges, and other intense Yes No urges, while taking PD medicines, including APOKYN. If you experience new or increased urges, tell your healthcare provider. 6. Would your daily activities be easier if you had a reliable PD If you experience shortness of breath, fast heartbeat, chest pain, a change in your heartbeat, or faint while taking treatment that rapidly ended 95% of your off times in as early as APOKYN, you should call your healthcare provider right away. The most common side effects seen in clinical studies with APOKYN were: yawning; sleepiness; dyskinesias; dizziness; 10 minutes? runny nose; nausea and/or vomiting; hallucinations/confusion; and swelling of hands, arms, legs, and feet. Some patients may notice soreness, redness, bruising, or itching at the injection site. Change the site with each Yes No injection. APOKYN may cause prolonged, painful erections in some people. If you have an erection that lasts more than 4 hours, If you answered Yes to any of these questions, you should call your healthcare provider right away. Tell your healthcare provider if you are pregnant, plan to become pregnant, if you are breast-feeding or planning to APOKYN may be right for you. breast-feed. It is not known if APOKYN can harm your unborn baby or if APOKYN passes into breast milk. To report SUSPECTED ADVERSE REACTIONS or product complaints, contact US WorldMeds at 1-877-727-6596 (1-877-7APOKYN). You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Patients and care partners must receive complete instructions on the proper use of APOKYN. Please see full Prescribing Information and Pen Instructions for Use/Patient Information. Ask your doctor about how APOKYN can help you be on and live life. All trademarks are property of their respective owners. References: 1. Christmann BL, et al. Decision Resources Group. December 2015. 2. Pfeiffer RF, et al. Parkinsonism Relat Disord. 2007;13(2):93-100. 3. Pahwa R, et al. J Neurol Sci. 2007;258:137-143. 4. Swope DM. Neurology. 2004;62 (Suppl4):S27-S31. 5. Stacy M, et al. Parkinsonism Relat Disord. 2008;14:85-92. 6. Jankovic J. Mov Disord. 2005;20 (Suppl11):S11–S16. 7. Isaacson S, et al. Mov Disord Clin Pract. 2017;4(1):78–83. 8. Hechtner MC, et al. Please see the Important Safety Information on back page and the accompanying Parkinsonism Relat Disord. 2014;20:969–974. full Prescribing Information and Pen Instructions for Use/Patient Information. apokyn.com