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1 2 COMMITTEES Course Organizing Committee: María Soledad Espósito María Sol Fustiñana Joaquín Piriz Lorena Rela Meeting Organizing Committee: Ana Belén Elgoyhen Diego Gelman Pablo Helguera Rafael Pagani Arturo Romano Sociedad Argentina de Investigación en Neurociencias (SAN) President : Ana Belén Elgoyhen Vice-president : Arturo Romano Former president : Alejandro Schinder Secretary : Jesica Raingo Treasurer : Lorena Rela Vocal : Tomás Falzone Vocal : Liliana Cancela Vocal : M. Gustavo Murer Secretariat : Silvina Ceriani and Pablo Bramajo 3 Imagen de tapa: Daniela Di Bella 4 5 6 Dear SAN members, friends and colleagues: On behalf of the 2015 organizing committee and the SAN Board of Directors, it is my great pleasure to welcome you all to our XXX Annual Meeting, to the SAN-ISN special small conference and to the celebration of the 30th anniversary of the Sociedad Argentina de Investigación en Neurociencias. SAN was created by a group of pioneers who felt that it was the right time to acquire a differential identity from the classical school of biochemistry that characterized Argentine science. It was born as the Sociedad Argentina de Neuroquímica and one of its foundational missions was to promote the development of neurochemistry in our country. Ranwel Caputto, Department of Biological Chemistry, University of Córdoba, best known forhis work on ganglioside biochemistry in the nervous system, was SAN´s first president. Very quickly Argentine neuroscience grew in size and scope, beyond the borders of neurochemistry. A group of scientists, young investigators and students decided to organize yearly workshops to discuss their work in a friendly atmosphere and in a secluded place that would foster intense scientific discussions. Thus, the Taller Argentino de Neurociencias took shape. It was characterized by an important participation of students who were highly involved in the organization and by its lively discussions. During 2009 and 2010 SAN and Taller organized joint meetings in order to re-unite the entire neuroscience community. SAN renovated its name to Sociedad Argentina de Investigación en Neurociencias, and since 2011 the SAN Annual Meeting has been our yearly reunion. The Argentinean neuroscience community continues to grow and SAN has more than 600 members. It encompasses all areas of neuroscience, from cellular and molecular to cognitive and computational sciences. The XXX Annual meeting will be a clear reflection of the growth and strength of our society. With 400 participants, a very high quality scientific program and a shift in venue from the hills to the sea, we look forward to a vibrant, lively and exciting meeting. We want to thank the invited speakers who have traveled long distances to share their recent discoveries and all SAN members and participants for your continuing support to the society. A special thanks to sponsors and exhibitors that have supported this XXX Annual Meeting and celebration of the SAN 30th anniversary. Welcome all and enjoy the meeting. Ana Belén Elgoyhen SAN President 7 8 Index Program………………………………………………….……… 11 Recipients of Young ISN Neurochemistry Awards……………… 25 Abstracts: Course…………………………………………………. 29 Meeting: Plenary………………………………………… 33 Symposia………………………………………. 37 Young Investigator Symposium…………..…… 66 Short Talks………………………………..…… 78 Posters………………………………………… 94 9 10 SAN-ISN Course “State-of-the-art methods in Neuroscience Research” ROOM TOPACIO PROGRAM DAY 1: Sunday September 27 th 18:00-19:00 Registration 19:15-19:30 Welcome words by course organizers 19:30-21:00 Lecture I: “Mapping neuronal networks with viral tools” María Soledad Espósito , Friedrich Miescher Institute, Basel, Switzerland 21:00 Dinner DAY 2: Monday September 28 th 09:00-10:30 Lecture II: “In vivo 2-photon microscopy for dissection of neuronal circuits” Johannes Letzkus , Max Planck Institute for Brain Research, Frankfurt, Germany 10:30-11:00 Coffee Break 11 11:00-12:30 Lecture III: “Visualizing large-scale neural ensemble dynamics in freely behaving mice" Mark Schnitzer , Stanford School of Medicine, Howard Hughes Medical Institute, USA 12:30 -13:30 Lunch 14:00-15:30 Session A: Group 1-14 – paper discussion 16:00-17:30 Session B: Group 15-28 – paper discussion 17:30-19:00 Lecture IV: “Dissecting neuronal circuits using chemical genetic tools” Marcelo de Oliveira Dietrich, Yale School of Medicine, USA 19:00-19:30 Break 19:30-21:00 Lecture V: "In vivo optogenetics and electrophysiology" Alexxai Kravitz, NIDDK, NIDA, USA 21:00-23:00 Dinner and Poster presentation (Room Mediterráneo) DAY 3: Tuesday September 29 th 8:30-10:30 Session A: Group 15-28 – paper discussion 11:00-13:00 Session B: Group 1-14 – paper discussion 12 XXX REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS PROGRAM DAY 1: Tuesday September 29 th 09:00-12:00 Registration 14:15 Welcome by Organizers (Room Atlantic) 14:30-15:30 Special Lecture (Room Atlantic) Chair: Joaquín Piriz , Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina "Next-generation optical technologies for cracking neural codes" Mark Schnitzer, Departments of Biological Sciences and of Applied Physics, Stanford School of Medicine, Howard Hughes Medical Institute, USA 15:30-16:00 Coffee break (Room Mediterráneo) 16:00-18:30 Symposium 1 & Symposium 2 Symposium 1 GADOR Symposium (Room Atlantic) “Technological advances to dissect neural circuits controlling behavior” Chair: M. Sol Fustiñana and M. Soledad Esposito , Friedrich Miescher Institute, Basel, Switzerland 13 - “Temporal stability of aversive memories is determined by Lateral Habenula activity” Joaquin Piriz , Instituto de Fisiología y Biofísica Bernardo Houssay, CONICET, Argentina - “Multitasking of AGRP neurons in metabolism and behavior” Marcelo de Oliveira Dietrich , Yale School of Medicine, USA - “Spontaneous neuronal network dynamics reveals circuit's functional adaptations for behavior” Sebastián A. Romano , Ecole Normale Supérieure, IBENS, Paris, France - “Disinhibition, a circuit mechanism for associative learning” Johannes Letzkus , Max Planck Institute for Brain Research, Frankfurt, Germany Symposium 2 (Room Topacio) “Glia at the Round Table: Microglia, Oligodendroglia and Astroglia in a Fruitful Dialogue” Chair: Juan María Pasquini , University of Buenos Aires, School of Pharmacy and Biochemistry, Argentina and Alberto Javier Ramos , Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Glia and Nervous System Energy Metabolism” Bruce Ransom , University of Washington, Seattle, USA 14 - “Analysis of myelination and remyelination in the optic nerve” Alain Chedotal , University of Paris, France - “Atypical astrocytes are present in the ischemic lesions and contribute to the expansion of reactive gliosis" Alberto Javier Ramos , Instituto de Biología Celular y Neurociencia, Prof. E. De Robertis, UBA-CONICET, Argentina - “Mag as key player of the bi-directional communication between axons and myelin: its impact on postnatal development and disease” Pablo Lopez , Instituto de Investigación Médica Mercedes y Martín Ferreyra, CONICET, Argentina 18:45-19:30 Opening Ceremony and Tribute to Past Presidents (Room Atlantic) 19:30-20:30 Opening Lecture (Room Atlantic) Chair: Ana Belén Elgoyhen , Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina “Emergence and mechanisms of cognition” György Buzsáki, The Neuroscience Institute, New York University School of Medicine, Ney York, USA 21:00 Welcome Reception Hotel 13 de Julio 15 DAY 2: Wednesday September 30 th 08:30-11:00 Symposium 3 & Symposium 4 Symposium 3 (Room Atlantic) “2015, The International Year of Light: Superresolution microscopies in Neuroscience” Chair: Francisco Barrantes , Instituto Investigaciones Biomédicas, UCA–CONICET, Argentina - “Nanoscopy 2.0. Converging and correlative technologies” Alberto Diaspro , Department of Nanophysics at the Istituto Italiano di Tecnologia, Genova, Italy - “Visualizing the details of neuronal polarity with fluorescence nanoscopy” Fernando Stefani, Centro de Investigaciones en Bionanociencias, Buenos Aires, Argentina - “Social organization of neurotransmitter receptor nanoclusters” Francisco Barrantes , Instituto Investigaciones Biomédicas, UCA–CONICET, Argentina - “Resolft microscopy of living cells in the nervous system" Ilaria Testa - Royal Institute of Technology, Stockholm, Sweden Symposium 4 (Room Topacio) “Translational approaches to model and treat SNC diseases ” 16 Chair: Elena Avale and Marcelo Rubinstein , Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina - “Levodopa induced dyskinesias: from classical pharmacology to molecular mechanisms” Oscar Gershanik , Instituto de Neurociencias de la Fundación Favaloro, Instituto de Investigaciones Farmacológicas, CONICET, Argentina - “Alzheimer’s disease, from a dish to the bed” Gorazd Bernard Stokin , St. Anne’s University Hospital, Brno, Czech Republic, Division of Neurology, University Medical Centre, Ljubljana, Slovenia - “What Can Movement Circuitry Tell Us About Obesity?” Alexxai Kravitz , NIDDK, NIDA, USA - “Phenotypic rescue in a mouse model of tauopathy using trans-splicing RNA reprogramming” Elena Avale , Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, CONICET, Argentina 11:00-11:30 Coffee break 11:30-13:15 Short Talks by students (1 & 2) Short Talks by Students 1 (Room Atlantic) Chair: Estela Maris Muñoz , Instituto