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Home , Dimenhydrinate

- 1  ANTI- GROUP 1 ANTI- HISTAMINE

1.1 • CHLORPHENIRAMINE MALEATE Indication: For perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria. Unlabeled/investigation indication: N/A Usual dose: Oral 4 mg every 4-6 hours, not to exceed 24 mg/day . IV or IM or SubQ 5-40 mg. Adverse Reaction: - Central nervous system: Drowsiness,headache, excitability, fatigue, nervousness, dizziness - Respiratory: Thickening of bronchial secretions - Gastrointestinal: , xerostomia, diarrhea, abdominal pain, appetite increase, weight gain - Genitourinary: Urinary retention - Neuromuscular & skeletal: Arthralgia, weakness - Ocular: Diplopia - Renal: Polyuria - Respiratory: Pharyngitis Pregnancy risk factor: B Lactation: N/A Preparations: Tablets 4 mg ED(7) Injection 10 mg/mg ED(7), Syrup 2 mg/5 mL ED(7)

• Indication: Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria Unlabeled/investigation indication: Appetite stimulation, blepharospasm, cluster headaches, migraine headaches, Nelson's syndrome, pruritus, schizophrenia, spinal cord damage associated spasticity, and tardive dyskinesia Usual dose: Allergic conditions : Oral: 4-20 mg/day divided every 8 hours (not to exceed 0.5 mg/kg/day). Appetite stimulation : Oral 2 mg 4 times/day. Adverse Reaction: - Central nervous system: Drowsiness, dizziness, fatigue, headache, nervousness - Gastrointestinal: Abdominal pain, appetitie stimulation, diarrhea, nausea, xerostomia - Neuromuscular & skeletal: Arthralgia - Respiratory: Thickening of bronchial secretions, pharyngitis Pregnancy risk factor: B Lactation: Excretion in breast milk unknown/contraindicated Preparations: Tablets 4 mg ED(7)

  .!.2553  % &' %'   ()* +,)'& - 2  ANTI-HISTAMINE • HYDROCHLORIDE Indication: Relief of allergic symptoms caused by histamine release, prevention of , antitussive, -induced extrapyramidal symptoms and can be used for mild nighttime sedation. Unlabeled/investigation indication: N/A Usual Dose: Oral 25-50 mg 3-4 times/day every 4-6 hours, night-time sleep aid 50 mg at bedtime, not to exceed 400 mg/day . Adverse Reaction: - Cardiovascular: Hypotension, palpitation, - Central nervous system: Sedation, sleepiness, dizziness, disturbed coordination, headache, fatigue, nervousness, paradoxical excitement, , , - Dermatologic: Photosensitivity, rash, angioedema, urticaria - Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain, xerostomia, appetite increase, weight gain, dry mucous membranes, anorexia - Genitourinary: Urinary retention, urinary frequency, difficult urination - Hematologic: Hemolytic anemia, thrombocytopenia, agranulocytosis - Neuromuscular & skeletal: Tremor, paresthesia - Ocular: Blurred vision - Respiratory: Thickening of bronchial secretions Respiratory: Pharyngitis Pregnancy risk factor: B Lactation: Enters breast milk/contraindicated Preparations: Capsules 25 mg ED(7)

• DIMENHYDRINATE Indication: Treatment and prevention of nausea, , and vomiting associated with motion sickness. Unlabeled/investigation indication: Treatment of Meniere's disease Usual Dose: Oral: 50-100 mg every 4-6 hours, not to exceed 400 mg/day . Adverse Reaction: - Central nervous system: drowsiness, headache, fatigue, nervousness, dizziness - Gastrointestinal: Abdominal pain, diarrhea, increased appetite, nausea, weight gain, xerostomi - Neuromuscular & skeletal: Arthralgia - Respiratory: Thickening of bronchial secretions, pharyngitis Pregnancy risk factor: B Lactation: Enters breast milk/contraindicated Preparations: Tablets 50 mg ED(7), Injection 50 mg/mL ED(7)

  .!.2553  % &' %'   ()* +,)'& - 3  ANTI-HISTAMINE • HYDROCHLORIDE Indication: Treatment of anxiety, preoperative sedative, antipruritic. Unlabeled/investigation indication: , ethanol withdrawal symptoms. Usual Dose: Pruritus : Oral 25 mg 3-4 times/day. Anxiety: Oral 50-100 mg 4 times/day. Preoperative sedation: Oral 50-100 mg. Adverse Reaction: - Central nervous system: Dizziness, drowsiness, fatigue, hallucination, headache, nervousness - Dermatologic: Pruritus, rash, urticaria - Gastrointestinal: Xerostomia - Neuromuscular & skeletal: Involuntary movements, paresthesia, tremor - Ocular: Blurred vision - Respiratory: Thickening of bronchial secretions - Miscellaneous: Allergic reaction Pregnancy risk factor: C Lactation: Excretion in breast milk unknown/not recommended Preparations: Tablets 10 mg ED(7), 25 mg ED(7)

• HCL + PSEUDOEPHEDINE HCL Indication: Temporary relief of nasal congestion, decongest sinus openings, running nose, sneezing, itching of nose or throat and itchy, watery eyes due to common cold, hay fever, or other upper respiratory allergies Unlabeled/investigation indication: N/A Usual Dose: Oral 1 every 4-6 hours; do not exceed 4 doses in 24 hours. Adverse Reaction: - Cardiovascular: Tachycardia - Central nervous system: Drowsiness, nervousness, insomnia, transient stimulation, headache, fatigue, dizziness - Respiratory: Thickening of bronchial secretions, pharyngitis - Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia - Genitourinary: Dysuria - Neuromuscular & skeletal: Arthralgia, weakness - Miscellaneous: Diaphoresis Pregnancy risk factor: C Lactation: N/A Preparations: Tablets NED (Triprolidine hydrochloride 2.5 mg+ Pseudoephedrine hydrochloride 60 mg)

  .!.2553  % &' %'   ()* +,)'& - 4  ANTI-HISTAMINE 1.2 NON-SEDATIVE ANTIHISTAMINE • DIHYDROCHLORIDE Indication: Perennial and seasonal allergic rhinitis and other allergic symptoms including urticaria, chronic idiopathic urticaria Unlabeled/investigation indication : N/A Usual Dose: Oral 5-10 mg once daily Adverse Reaction: - Central nervous system: Headache, somnolence, insomnia, fatigue, malaise, dizziness - Gastrointestinal: Abdominal pain, dry mouth, diarrhea, nausea, vomiting - Respiratory: Epistaxis, pharyngitis, bronchospasm Pregnancy risk factor: B Lactation: Enters breast milk/not recommended Preparations: Tablets 10 mg ED(7)

• HCL Indication: Relief of symptoms associated with seasonal allergic rhinitis, treatment of chronic idiopathic urticaria. Unlabeled/investigation indication : N/A Usual Dose: Oral 60 mg twice daily or 180 mg once daily . Adverse Reaction: - Central nervous system: Headache, somnolence, dizziness, drowsiness, pain, fatigue - Gastrointestinal: Vomiting,dyspepsia, diarrhea, nausea - Endocrine & metabolic: Dysmenorrhea - Neuromuscular & skeletal: Myalgia, back pain - Otic: Otitis media - Respiratory: Upper respiratory tract infection, cough, nasopharyngitis - Miscellaneous: Viral infection, hypersensitivity reactions Pregnancy risk factor: C Lactation: Excretion in breast milk unknown/use caution (AAP rates "compatible") Preparations: Tablets 60 mg NED

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