International Journal of Environmental Research and Public Health Article Efficacy and Pharmacological Appropriateness of Cinnarizine and Dimenhydrinate in the Treatment of Vertigo and Related Symptoms Fulvio Plescia 1 , Pietro Salvago 2, Francesco Dispenza 3, Giuseppe Messina 4,5 , Emanuele Cannizzaro 1 and Francesco Martines 2,* 1 Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, Via del Vespro 133, 90127 Palermo, Italy;
[email protected] (F.P.);
[email protected] (E.C.) 2 Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata (BiND), Sezione di Audiologia, Università Degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, Italy;
[email protected] 3 UOC Otorinolaringoiatria, A.O.U.P. “Paolo Giaccone”, Via del Vespro 129, 90127 Palermo, Italy;
[email protected] 4 Department of Psychological, Pedagogical and Human Movement Sciences, University of Palermo, Via Giovanni Pascoli 6, Palermo 90144, Italy;
[email protected] 5 PosturaLab Center, 90127 Palermo, Italy * Correspondence:
[email protected] Abstract: Vertigo is not itself a disease, but rather a symptom of various syndromes and disorders that jeopardize balance function, which is essential for daily activities. It is an abnormal sensation of motion that usually occurs in the absence of motion, or when a motion is sensed inaccurately. Due to Citation: Plescia, F.; Salvago, P.; the complexity of the etiopathogenesis of vertigo, many pharmacological treatments have been tested Dispenza, F.; Messina, G.; Cannizzaro, for efficacy on vertigo. Among these drugs, cinnarizine, usually given together with dimenhydrinate, E.; Martines, F. Efficacy and appears to be the first-line pharmacotherapy for the management of vertigo and inner ear disorders.