Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Tebanicline Catalog Number : T3694 CAS Number : 198283-73-7 Molecular Formula : C9H11ClN2O Molecular Weight : 198.65

Description: Tebanicline (ABT-594, Ebanicline) acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. Tebanicline is an effective synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analog of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, Tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

DMSO Soluble Solubility ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Receptor (IC50) nAChR

Reference 1. Hayashi T, et al.Neurosci Lett. 2016 Dec 7;638:46-50. 2. Nirogi R. et al. Eur J Pharmacol. 2011 Oct 1;668(1-2):155-62.

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