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Vacinas Baseadas Em Vírus Inativado Para Prevenção Da Covid-19
MINISTÉRIO DA ECONOMIA INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL OBSERVATÓRIO DE TECNOLOGIAS RELACIOADAS À COVID-19 VACINAS BASEADAS EM VÍRUS INATIVADO PARA PREVENÇÃO DA COVID-19 Autora: Tatiana Carestiato da Silva Colaboradoras: Cristina d’Urso de Souza Mendes Irene von der Weid Leticia Galeazzi Ferraz Núbia Gabriela Benício Chedid Nota de Copyright: Autorizada a reprodução desde que seja citada a fonte Equipe Observatório COVID-19 Alexandre Lopes Lourenço Cristina d’Urso de Souza Mendes Irene von der Weid Leticia Galeazzi Ferraz Núbia Gabriela Benício Chedid Tatiana Carestiato VACINAS BASEADAS EM VÍRUS INATIVADO Ademais, a invasão viral induz dano nas células, PARA PREVENÇÃO DA COVID-19 piroptose, infiltração de células imunes, expressão de citocinas pró-inflamatórias (tempestade de citocinas) e ativação do sistema imune adaptativo. Dependendo da carga viral e de 1. INTRODUÇÃO fatores do hospedeiro, como idade e condições médicas subjacentes, as respostas imunes contra o SARS-CoV-2 podem causar síndrome do desconforto respiratório agudo (SDRA), A COVID-19 é uma doença respiratória infecciosa falência de múltiplos órgãos e até a morte (Figura 2) (Chugh, et causada pelo SARS-CoV-2 (Figura 1) um novo beta al., 2021). coronavírus. Sendo principalmente uma doença respiratória, Os primeiros quadros respiratórios provocados pela ela é altamente transmissível por contatos diretos e indiretos e COVID-19 foram reportados às autoridades internacionais em exibe uma variedade de sintomas em diferentes indivíduos 31 de dezembro de 2019. Em janeiro de 2020, menos de um (Chugh, et al., 2021). mês depois que surgiram os primeiros relatórios da doença respiratória que estava atingindo as pessoas na cidade chinesa de Wuhan, os pesquisadores do país identificaram a causa: um novo coronavírus, que logo se chamaria SARS-CoV-2. -
Coronavirus: Quello Che C'è Da Sapere – 7 Giugno 2021
Coronavirus: quello che c’è da sapere – 7 giugno 2021 Sommario Quando è iniziata l’epidemia? ...................................................................2 Come viene diagnosticata la malattia Covid-19? ...................................23 Quando è arrivata in Italia? .......................................................................2 Che cosa sono i test sierologici? a cosa servono? ................................25 A cosa è dovuta l’infezione? .....................................................................2 Chi viene colpito dalla malattia Covid-19? ............................................25 Quanto è diffusa l’epidemia? ....................................................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................25 Che cosa sono i coronavirus? ...................................................................2 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....29 Qual è l’origine del virus? .........................................................................4 Il virus può mutare? ..................................................................................4 Esiste un vaccino? ...................................................................................31 Come si trasmette l’infezione? .................................................................9 Quali sono le terapie disponibili?............................................................46 I bambini sono più soggetti all’infezione? .............................................13 -
Microsoft Outlook
Morris, Max From: Morris, Max Sent: Wednesday, June 30, 2021 8:27 PM To: Morris, Max Subject: 06/30/2021 Coronavirus Daily Recap This email is provided for informational, non-commercial purposes only. Use or reliance on the information contained in this email is at your sole risk. This email is not provided by or affiliated in any way with Ally Financial Inc. These updates are being shared to multiple organizations, individuals and lists who/which are bcc’d. Best effort we are sending Daily updates during the business week, typically in the evening, a Weekend Recap on Monday mornings, and any significant breaking news events provided anytime. Please note some numbers included in the Statistics and news stories come from various sources and so can vary as they are constantly changing and not reported at the same time. All communications are TLP GREEN and can be shared freely. Know someone who might want to be added to our Updates? Of course ask them first, and then have them send us an email to [email protected]. Need to find a vaccine? Here are a few good sites and resources we have come across that may help: White House Vaccine Resource - Website to make it easier for people to find information, https://www.vaccines.gov/, and people can also text their zip code to 438829 to find out information about vaccination sites. CDC Vaccine Finder – https://vaccinefinder.org/ [Free government website where users can search for pharmacies and providers that offer vaccinations, currently limited number of states but expanding] Dr. -
Coronavirus: Quello Che C'è Da Sapere – 26 Maggio 2021
Coronavirus: quello che c’è da sapere – 26 maggio 2021 Sommario Quando è iniziata l’epidemia? ...................................................................2 Come viene diagnosticata la malattia Covid-19? ...................................23 Quando è arrivata in Italia? .......................................................................2 Che cosa sono i test sierologici? a cosa servono? ................................24 A cosa è dovuta l’infezione? .....................................................................2 Chi viene colpito dalla malattia Covid-19? ............................................25 Quanto è diffusa l’epidemia? ....................................................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................25 Che cosa sono i coronavirus? ...................................................................2 Qual è l’origine del virus? .........................................................................4 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....29 Il virus può mutare? ..................................................................................5 Esiste un vaccino? ...................................................................................31 Come si trasmette l’infezione? .................................................................9 Quali sono le terapie disponibili?............................................................45 I bambini sono più soggetti all’infezione? .............................................13 -
Coronavirus: Quello Che C’È Da Sapere – 9 Aprile 2021 Sommario Quando È Iniziata L’Epidemia?
Coronavirus: quello che c’è da sapere – 9 aprile 2021 Sommario Quando è iniziata l’epidemia? ...................................................................2 Come viene diagnosticata la malattia Covid-19? ...................................21 Quando è arrivata in Italia? .......................................................................2 Che cosa sono i test sierologici? a cosa servono? ................................23 A cosa è dovuta l’infezione? .....................................................................2 Chi viene colpito dalla malattia Covid-19? ............................................24 Quanto è diffusa l’epidemia? ....................................................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................24 Che cosa sono i coronavirus? ...................................................................2 Qual è l’origine del virus? .........................................................................4 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....26 Il virus può mutare? ..................................................................................5 Esiste un vaccino? ...................................................................................27 Come si trasmette l’infezione? .................................................................9 Quali sono le terapie disponibili?............................................................37 I bambini sono più soggetti all’infezione? .............................................11 -
Coronavirus: Quello Che C'è Da Sapere – 12 Agosto 2021
Coronavirus: quello che c’è da sapere – 12 agosto 2021 Sommario Quando è iniziata l’epidemia? ......................................2 Che cosa sono i test sierologici? a cosa servono? ................................26 Quando è arrivata in Italia? ..........................................2 Chi viene colpito dalla malattia Covid-19? ............................................27 A cosa è dovuta l’infezione? .........................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................27 Quanto è diffusa l’epidemia? ....................................................................2 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....31 Che cosa sono i coronavirus? ...................................................................2 Qual è l’origine del virus? .........................................................................4 Il virus può diventare endemico?............................................................33 Il virus può mutare? ..................................................................................5 Esiste un vaccino? ...................................................................................33 Come si trasmette l’infezione? ...............................................................10 Quali sono le terapie disponibili?............................................................51 I bambini sono più soggetti all’infezione? .............................................15 Quali sono i rischi sanitari legati all’epidemia? .....................................64 -
Coronavirus: Quello Che C'è Da Sapere – 28 Maggio 2021
Coronavirus: quello che c’è da sapere – 28 maggio 2021 Sommario Quando è iniziata l’epidemia? ...................................................................2 Come viene diagnosticata la malattia Covid-19? ...................................23 Quando è arrivata in Italia? .......................................................................2 Che cosa sono i test sierologici? a cosa servono? ................................25 A cosa è dovuta l’infezione? .....................................................................2 Chi viene colpito dalla malattia Covid-19? ............................................25 Quanto è diffusa l’epidemia? ....................................................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................25 Che cosa sono i coronavirus? ...................................................................2 Qual è l’origine del virus? .........................................................................4 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....29 Il virus può mutare? ..................................................................................5 Esiste un vaccino? ...................................................................................31 Come si trasmette l’infezione? .................................................................9 Quali sono le terapie disponibili?............................................................45 I bambini sono più soggetti all’infezione? .............................................13 -
Microsoft Outlook
Morris, Max From: Morris, Max Sent: Monday, June 28, 2021 8:36 PM To: Morris, Max Subject: 06/28/2021 Coronavirus Daily Recap This email is provided for informational, non-commercial purposes only. Use or reliance on the information contained in this email is at your sole risk. This email is not provided by or affiliated in any way with Ally Financial Inc. These updates are being shared to multiple organizations, individuals and lists who/which are bcc’d. Best effort we are sending Daily updates during the business week, typically in the evening, a Weekend Recap on Monday mornings, and any significant breaking news events provided anytime. Please note some numbers included in the Statistics and news stories come from various sources and so can vary as they are constantly changing and not reported at the same time. All communications are TLP GREEN and can be shared freely. Know someone who might want to be added to our Updates? Of course ask them first, and then have them send us an email to [email protected]. Need to find a vaccine? Here are a few good sites and resources we have come across that may help: White House Vaccine Resource - Website to make it easier for people to find information, https://www.vaccines.gov/, and people can also text their zip code to 438829 to find out information about vaccination sites. CDC Vaccine Finder – https://vaccinefinder.org/ [Free government website where users can search for pharmacies and providers that offer vaccinations, currently limited number of states but expanding] Dr. -
Coronavirus Vaccine Tracker
https://nyti.ms/2MHNdRL U.S.A. World Health Coronavirus Vaccine Tracker By Carl Zimmer, Jonathan Corum and Sui-Lee Wee Updated April 5, 2021 PHASE 1 PHASE 2 PHASE 3 AUTHORIZED APPROVED ABANDONED 50 35 23 5 8 4 Vaccines Vaccines Vaccines Vaccines Vaccines Vaccines testing safety in expanded in large-scale in early or approved abandoned and dosage safety trials efficacy tests limited use for full use after trials Vaccines typically require years of research and testing before reaching the clinic, but in 2020, scientists embarked on a race to produce safe and effective coronavirus vaccines in record time. Researchers are currently testing 86 vaccines in clinical trials on humans, and 23 have reached the final stages of testing. At least 77 preclinical vaccines are under active investigation in animals. New additions and recent updates April 5 The Walter Reed Army Institute of Research enters Phase 1. April 5 Japanʼs KM Biologics begins Phase 1/2. April 2 Franceʼs OSE Immunotherapeutics enters Phase 1. March 31 The Pfizer-BioNTech vaccine is highly effective in adolescents. March 31 Some Johnson & Johnson doses are delayed by a U.S. factory mix-up. March 30 Chinaʼs Jiangsu Rec-Biotechnology enters Phase 1. March 27 Turkeyʼs Middle East Technical and Bilkent University begin Phase 1. March 25 A vaccine from Chinaʼs Zhongyianke Biotech enters Phase 2. March 23 U.S. officials question the completeness of AstraZenecaʼs trial results. March 23 Daiichi Sankyo and the University of Tokyo enter Phase 1/2. March 22 AstraZenecaʼs vaccine is found to be 79% effective in a large U.S. -
Coronavirus: Quello Che C'è Da Sapere – 19 Luglio 2021
Coronavirus: quello che c’è da sapere – 19 luglio 2021 Sommario Quando è iniziata l’epidemia? ......................................2 Che cosa sono i test sierologici? a cosa servono? ................................26 Quando è arrivata in Italia? ..........................................2 Chi viene colpito dalla malattia Covid-19? ............................................26 A cosa è dovuta l’infezione? .........................................2 Quanto è letale il virus? Quali sono i fattori di rischio? .........................26 Quanto è diffusa l’epidemia? ....................................................................2 Quali sono le conseguenze a medio e lungo termine del Covid-19? .....31 Che cosa sono i coronavirus? ...................................................................2 Qual è l’origine del virus? .........................................................................4 Il virus può diventare endemico?............................................................32 Il virus può mutare? ..................................................................................4 Esiste un vaccino? ...................................................................................33 Come si trasmette l’infezione? ...............................................................10 Quali sono le terapie disponibili?............................................................48 I bambini sono più soggetti all’infezione? .............................................14 Quali sono i rischi sanitari legati all’epidemia? .....................................60 -
COVID-19 Vaccines: a Review of the Safety and Efficacy of Current
pharmaceuticals Review COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials Zhi-Peng Yan 1,*,† , Ming Yang 2,† and Ching-Lung Lai 1,* 1 Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong 999077, China 2 Department of Ophthalmology, The University of Hong Kong, Hong Kong 999077, China; [email protected] * Correspondence: [email protected] (Z.-P.Y.); [email protected] (C.-L.L.); Tel.: +852-2255-4252 (C.-L.L.); Fax: +852-2816-2863 (C.-L.L.) † Co-first authors. Abstract: Various strategies have been designed to contain the COVID-19 pandemic. Among them, vaccine development is high on the agenda in spite of the unknown duration of the protection time. Various vaccines have been under clinical trials with promising results in different countries. The protective efficacy and the short-term and long-term side effects of the vaccines are of major concern. Therefore, comparing the protective efficacy and risks of vaccination is essential for the global control of COVID-19 through herd immunity. This study reviews the most recent data of 12 vaccines to evaluate their efficacy, safety profile and usage in various populations. Citation: Yan, Z.-P.; Yang, M.; Lai, C.-L. COVID-19 Vaccines: A Review Keywords: COVID-19; vaccine; safety; efficacy; herd immunity of the Safety and Efficacy of Current Clinical Trials. Pharmaceuticals 2021, 14, 406. https://doi.org/10.3390/ ph14050406 1. Introduction The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus Academic Editor: Juan Carlos Saiz 2 (SARS-CoV-2). Up till February 2021 it had infected more than 110 million patients, causing 2.4 million deaths worldwide, according to data recorded by the World Health Received: 25 March 2021 Organization (WHO) [1]. -
Reasons for Success and Lessons Learnt from Nanoscale Vaccines Against COVID-19
comment Reasons for success and lessons learnt from nanoscale vaccines against COVID-19 Almost all currently used vaccines against COVID-19 consist of either non-viral or viral nanoparticles. Here we attempt to understand the reasons behind the success of such advanced nanoscale vaccine technologies compared with clinically established conventional vaccines, and the lessons to be learnt from this potentially transformative development in the adoption and acceptance of nanotechnology for medicine. Thomas Kisby, Açelya Yilmazer and Kostas Kostarelos he outbreak of a novel coronavirus vaccine technologies such as those almost all of the candidates falling within the (CoV) causing severe acute based on inactivated/attenuated virions nanoscale size range (Fig. 1). Trespiratory syndrome (SARS) was (entire virus particles) or on viral protein The current scale of administration initially identified in China in late 2019 and fragments, which have traditionally led and therefore exposure to non-viral or rapidly developed into a global pandemic the way in terms of clinical presence, viral nanoparticles constitutes an with devastating health and economic market share and regulatory approval, unprecedented phenomenon of historic consequences1. Driven by this, concerted have been clearly outplayed in both speed proportions and implications. The effort by hundreds of laboratories across and immunoprotective efficacy by highly immediate reaction, even by some members the world has led to the most rapid vaccine innovative technologies with no prior of the scientific community, has been to development in history, with clinical approved clinical use4. Even more remarkable acclaim nanoscience and nanomedicine trials of promising candidates completed is that most of these vaccine candidates rely as ‘saviours’ of humankind.