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Influenza Virus

Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C cause a mild respiratory illness and are not thought to cause epidemics. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.

www.MedChemExpress.com 1 Influenza Virus Inhibitors & Modulators

3,4'-Dihydroxyflavone hydrochloride (1-Adamantanamine hydrochloride; (3,4'-​DHF) Cat. No.: HY-111802 1-Adamantylamine hydrochloride; …) Cat. No.: HY-B0402A

Bioactivity: 3,4'-Dihydroxyflavone (3,4'-DHF) is an oral active flavonoid Bioactivity: Amantadine Hydrochloride is an antiviral and an with antiviral activity against Influenza A virus [1]. antiparkinsonian drug.

Purity: 98.20% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg 5 g, 10 g, 50 g

Aprotinin Arbidol hydrochloride Cat. No.: HY-P0017 ( hydrochloride) Cat. No.: HY-14904A

Bioactivity: Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) Bioactivity: Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively. enveloped viruses by blocking viral fusion with host cell membrane

Purity: Purity: 99.44% Clinical Data: Phase 4 Clinical Data: Phase 4 Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Baloxavir CEF1, Influenza Matrix Protein M1 58-66 Cat. No.: HY-109025A Cat. No.: HY-P0137

Bioactivity: Baloxavir is an anti-influenza agent extracted from patent WO Bioactivity: CEF1, Influenza Matrix Protein M1 (58-66) is an epitope 2017104691 A1. derived from the matrix protein of the influenza A virus [1].

Purity: 99.71% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CEF3 CEF6 Cat. No.: HY-P0289 Cat. No.: HY-P0313

Bioactivity: CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A Bioactivity: CEF6 is a 9-aa-long peptide corresponding to aa 418-426 of the virus M1 protein. The matrix (M1) protein of influenza A virus influenza A virus (H1N1) nucleocapsid protein. is a multifunctional protein that plays essential structural and functional roles in the virus life cycle.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

Dehydroandrographolide Desaminotyrosine Cat. No.: HY-N0676 (3-(4-Hydroxyphenyl)propionic acid) Cat. No.: HY-W015346

Bioactivity: Dehydroandrographolide is extracted from herbal medicine Bioactivity: Desaminotyrosine is a microbially associated metabolite Andrographis paniculata (Burm f) Nees; alleviate oxidative protecting from influenza through augmentation of type I stress in LPS-induced acute lung injury possibly by signaling. inactivating iNOS.

Purity: >98% Purity: 99.32% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 100 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Influenza A NP(366-374) Strain A/PR/8/35 Influenza NP 147-155 Cat. No.: HY-P1788 Cat. No.: HY-P1762

Bioactivity: Influenza A NP(366-374) Strain A/PR/8/35 is an Bioactivity: Influenza NP (147-155) is a K d restricted epitope from H2-Db-restricted epitope from Influenza A/PR/8/35 influenza nucleoprotein [1]. nucleoprotein [1].

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size:

JNJ4796 KIN1148 Cat. No.: HY-122907 Cat. No.: HY-101950

Bioactivity: JNJ4796 is an oral active fusion inhibitor of influenza virus, Bioactivity: KIN1148, a small-molecule IRF3 agonist, is a novel influenza neutralizing influenza A group 1 viruses by inhibiting vaccine adjuvant found to enhance flu vaccine efficacy. hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs) [1]. Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Laninamivir M2 ion channel blocker (L-Histidine, (R 125489) Cat. No.: HY-14818 N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, methyl ester) Cat. No.: HY-75867

Bioactivity: (R 125489) is a potent influenza neuraminidase Bioactivity: This compound is capable of inhibiting and blocking the activity of M2 ion channel. Antiviral agents. (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively [1]. Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 100 mg

M2e, human Moroxydine hydrochloride Cat. No.: HY-P1783 (ABOB hydrochloride) Cat. No.: HY-B0420A

Bioactivity: M2e, human, consisting of the 23 extracellular residues of M2 Bioactivity: Moroxydine HCl is a synthetic antiviral compound chemically (the third integral membrane protein of influenza A), has been belonging to the series of the heterocyclic biguanidines. remarkably conserved in all human influenza A, which is a Target: Influenza Virus Moroxydine is an that valid and versatile vaccine candidate to protect against any was originally developed in the 1950s as an influenza strain of human influenza A [1]. treatment. It has potential applications against a number of… Purity: >98% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: Launched Size: Size: 10mM x 1mL in Water, 100 mg, 500 mg, 1 g, 5 g, 10 g

Nitazoxanide Nitazoxanide D4 (NTZ; NSC 697855) Cat. No.: HY-B0217 (NTZ D4; NSC-697855 D4) Cat. No.: HY-B0217S

Bioactivity: Nitazoxanide is a synthetic nitrothiazolyl-salicylamide Bioactivity: Nitazoxanide D4 is the deuterium labeled Nitazoxanide, which derivative and an antiprotozoal agent. (IC50 for canine is an antiprotozoal agent. influenza virus ranges from 0.17 to 0.21 μM). Target: Others Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies… Purity: 95.24% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

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Nucleozin acid Cat. No.: HY-50001 (GS 4071; Ro 64-0802; oseltamivir carboxylate) Cat. No.: HY-13318

Bioactivity: Nucleozin targets influenza A nucleoprotein (NP), a Bioactivity: Oseltamivir acid (GS 4071; Ro 64-0802; oseltamivir multifunctional, RNA-binding protein necessary for virus carboxylate), the ethyl ester prodrug of GS 4071, is an

replication. IC50 Value: Target: Influenza Virus NP Nucleozin inhibitor of influenza virus neuraminidase with an IC50 of targets influenza A nucleoprotein, a multifunctional, approximately 100 nM. RNA-binding protein necessary for virus replication. It… Purity: 99.45% Purity: 98.60% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 50 mg

Oseltamivir phosphate PA (224-233), Influenza (GS 4104) Cat. No.: HY-17016 Cat. No.: HY-P1580

Bioactivity: Oseltamivir phosphate (GS 4104) is a Bioactivity: PA (224-233), Influenza is a 10-aa peptide, a fragment of recommended for the treatment and prophylaxis of influenza A polymerase 2 protein in influenza A virus. and B.

Purity: 99.85% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 100 mg, 500 mg

Peramivir trihydrate (RWJ-270201; BCX-1812) Cat. No.: HY-17015A (RWJ 270201 trihydrate; BCX 1812 trihydrate) Cat. No.: HY-17015

Bioactivity: Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a Bioactivity: Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

Purity: >98% Purity: 99.91% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg

Pimodivir RIG-1 modulator 1 (VX-787) Cat. No.: HY-12353A Cat. No.: HY-107902

Bioactivity: (VX-787) is an orally bioavailable inhibitor of Bioactivity: RIG-1 modulator 1 is an anti-viral compound which can be influenza A virus polymerases through interaction with the useful for the treatment of viral infections including viral PB2 subunit. influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1.

Purity: 99.04% Purity: 98.81% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 1 mg, 5 mg, 10 mg, 50 mg

Rimantadine hydrochloride (1-Rimantadine) Cat. No.: HY-B0338 Cat. No.: HY-B0338A

Bioactivity: Rimantadine (Flumadine) is an anti-influenza virus drug. Bioactivity: Rimantadine Hcl (Flumadine) is an anti-influenza virus drug.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg, 1 g

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RO-7 S119-8 Cat. No.: HY-112684 Cat. No.: HY-112543

Bioactivity: RO-7 is a next-generation polymerase (PA) endonuclease Bioactivity: S119-8 is a broad spectrum inhibitor of influenza A and B inhibitor of influenza A and B viruses. viruses.

Purity: >98% Purity: 99.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg, 250 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Sodium copper chlorophyllin SP187 Cat. No.: HY-B2226 (MON-​DNJ; UV4) Cat. No.: HY-U00160

Bioactivity: Sodium copper chlorophyllin exerts antiviral activities against Bioactivity: SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active Influenza virus and HIV with IC50s of 50 to 100 μM for both of them. against influenza and dengue in vivo.

Purity: Purity: 99.30% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g

Theaflavin Cat. No.: HY-N0243 Cat. No.: HY-13210

Bioactivity: Theaflavin is a suitable natural inhibitor against influenza A Bioactivity: Zanamivir is an influenza viral neuraminidase inhibitor ( H1N1) neuraminidase. with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

Purity: 99.09% Purity: 99.59% Clinical Data: No Development Reported Clinical Data: Launched Size: 2 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg

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