The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences in Vivo
The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo Cyril Ribeyre, Judith Lopes, Jean-Baptiste Boulé, Aurele Piazza, Aurore Guédin, Virginia Zakian, Jean-Louis Mergny, Alain Nicolas To cite this version: Cyril Ribeyre, Judith Lopes, Jean-Baptiste Boulé, Aurele Piazza, Aurore Guédin, et al.. The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo. PLoS Genetics, Public Library of Science, 2009, 5 (5), pp.e1000475. 10.1371/jour- nal.pgen.1000475. hal-02109281 HAL Id: hal-02109281 https://hal.archives-ouvertes.fr/hal-02109281 Submitted on 24 Apr 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo Cyril Ribeyre1.¤, Judith Lopes1., Jean-Baptiste Boule´ 1,2, Aure` le Piazza1, Aurore Gue´din3, Virginia A. Zakian2, Jean-Louis Mergny3, Alain Nicolas1* 1 Recombinaison et Instabilite´ Ge´ne´tique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite´ Pierre et Marie Curie, Paris, France, 2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, 3 Laboratoire de Biophysique, Museum National d’Histoire Naturelle USM 503, INSERM U565, CNRS UMR5153, Paris, France Abstract In budding yeast, the Pif1 DNA helicase is involved in the maintenance of both nuclear and mitochondrial genomes, but its role in these processes is still poorly understood.
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