CURRICULUM VITAE Dr. Jorge Torres, Assistant Professor 2009-Current Department of Chemistry and Biochemistry, University of California Los Angeles Office: 310-206-2092, Email: [email protected]

EDUCATION Postdoctoral Fellow Genentech INC, South San Francisco, CA 2006-2009 Department of Tumor and Angiogenesis

Stanford University, Palo Alto, CA 2004-2005 Department of Pathology

Ph.D. , Princeton, NJ 2004 Department of Molecular Biology

B.S. University of California, Santa Barbara, CA 1998 Department of Molecular Cellular and Developmental Biology

HONORS & AWARDS American Cancer Society Research Scholar Award 2014

Faculty Career Development Award, UCLA 2013

Cottrell Scholar Award, Research Corporation for Science Advancement 2013

Herbert Newby McCoy Award 2012

Faculty Career Development Award, UCLA 2012

Basil OʼConnor Award, March of Dimes Foundation 2011

V Scholar Award, The V Foundation for Cancer Research 2010

John McTague Career Development Chair 2009

Leukemia and Lymphoma Society Postdoctoral Fellowship 2005

Ruth L. Kirschstein National Research Service Award, NIH (declined) 2005

Stanford University Cancer Biology Postdoctoral Fellowship 2004

Leadership Alliance/Schering-Plough Fellowship 2003

Princeton University Molecular Biology Teaching Award 1999

Ford Baccalaureate Incentive Award for Outstanding Undergraduate Research 1998

Graduation Commencement Speaker 1998 MEMBERSHIPS UCLA Biomedical Engineering Interdepartmental Program (BME-IDP) 2011-Current UCLA Chemistry-Biology Interface Training Program (CBI) 2010-Current American Society for Biochemistry and Molecular Biology (ASBMB) 2010-Current UCLA Jonsson Comprehensive Cancer Center (JCCC) 2009-Current UCLA Molecular Biology Institute (MBI) 2009-Current UCLA BMB and ACCESS Graduate Programs 2009-Current American Society for Cell Biology (ASCB) 2005-Current

RESEARCH EXPERIENCE

Postdoctoral Fellow Proteomic and functional characterization of the mitotic spindle 2006-2009 Advisor : Dr. Peter Jackson, Genentech Inc

The ubiquitin proteasome system in cell cycle control 2004-2006 Advisor : Dr. Peter Jackson, Stanford University School of Medicine

Ph.D. Thesis The Rrm3p DNA helicase promotes genomic stability 1998-2003 Advisor: Dr. Virginia Zakian, Princeton University

Predoctoral Training Lab Rotation: Phenotypic characterization of piebald deficient mice 1998 Advisor: Dr. Shirley Tilghman, Princeton University

Lab Rotation: D. melanogaster deficiency screen for early developmental defects 1998 Advisor: Dr. Eric Wieschaus, Princeton University

Lab Rotation: Humanizing the yeast 1998 Advisor: Dr. Virginia Zakian, Princeton University

Undergraduate Training Undergraduate Research Project: Isolation and characterization of Telomere 1996-1998 Growth Inhibited Forever (TGIF) mutants in Tetrahymena thermophila Advisor: Dr. Eduardo Orias, University of California at Santa Barbara

Undergraduate Summer Research: Analysis of complete telomerase RNA 1997 substitution mutants in Tetrahymena thermophila Advisor: Dr. Elizabeth Blackburn, University of California at San Francisco

Undergraduate Summer Research: Tetrahymena Genome Project 1996 Advisor: Dr. Eduardo Orias, University of California at Santa Barbara

Undergraduate Summer Research: Anthropogenic effects on the sea anemone 1995 Advisor: Dr. Peter Girgis, University of California at Santa Barbara

2 Jorge Torres PUBLICATIONS

1. Bessler J.B., Torres J.Z., and Zakian V.A. “The Pif1p subfamily of helicases: region- specific DNA helicases?”, Trends in Cell Biology. 2001 Feb;11(2):60-65.

2. Torres J.Z., Bessler J.B., and Zakian V.A. “Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p” Genes & Development 2004 Mar 1;18(5):498-503.

3. Torres J.Z., Schnakenberg S.L. and Zakian V.A. “The Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra S phase checkpoint and fork restart activities”, Molecular and Cellular Biology 2004 Apr;24(8):3198-212.

4. Azvolinsky A, Dunaway S., Torres J.Z., Bessler B., and Zakian V.A. “The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes”, Genes & Development 2006 Nov 15;20(22):3104-16.

5. Ban K.H., Torres J.Z., Miller J.J., Mikhailov A., Nachury M.V., Tung J.J., Reider C.L. and Jackson P.K. “The END network couples spindle pole assembly to inhibition of the Anaphase Promoting Complex/Cyclosome in early mitosis”, Developmental Cell 2007 Jul;13(1):29-42.

6. Torres J.Z., Miller J.J. and Jackson P.K. “High throughput generation of tagged stable cell lines for proteomic analysis”, Proteomics 2009 May;9(10):2888-2891.

7. Torres J.Z., Ban K.H., and Jackson P.K. “A specific form of Phospho Protein Phosphatase 2 regulates Anaphase-promoting Complex/Cyclosome association with spindle poles”, Molecular Biology of the Cell 2010, March 15;21:897-904.

8. Torres J.Z.*, Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., and Jackson P.K. “The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly”, Cell 2011, Dec;9(6):1309-1323. *Corresponding Author

9. Torres, J.Z. “STARD9 is a novel mitotic kinesin and antimitotic target”, Bioarchitecture 2012 Jan 1;2(1):19-22.

10. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. “An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity”, Cancer Research 2013 Apr 22;73:2850-2862. PMID:23440422

11. Sakkiah, S., Arooj M., Lee K., and Torres J.Z. “Theoretical Approaches to Identify the Potent Scaffold for Human Sirtuin 1 Activator: Bayesian Modeling and Density Functional Theory” Medicinal Chemistry Research 2014 March 09, 23(5) 2161-2700.

3 Jorge Torres 12. Sakkiah S., Senese S., Yang Q., Lee K., and Torres J.Z. “Dynamic and Multi- pharmacophore Modeling for Designing Polo-box Domain Inhibitors” Plos One 2014 Jul 18, 9(7):e101405. PMCID: PMC4103762

Patent Torres J.Z., Senese S., Lo Y.C., Damoiseaux, R. The Microtaxls: A potent class of anti-cancer agents, US Patent Pending 2012

TEACHING EXPERIENCE MB298, The Cell Cycle: Mechanisms and Implications for Cancer Therapy 2013 C234, Ethics and Accountability in Biomedical Research 2012-2013 Chem 165/265, Posttranslational Modifications in Human Disease 2011-2014 Chem 269E, Cellular Assemblies 2010-2013 Guest lecture Chem 400 Safety in Chemical and Biochemical Research 2014 Guest lecture MSTP seminars, Targeting the Cell Division Machinery in Cancer 2009-2011 Guest lecture Biomedical Research 5B, Small Molecule Inhibitors of Cell Division 2012 Guest lecture Chem 269B, Novel Enzymatic Activities in Cell Division 2009 Assistant in Instruction: Advanced Genetics, Princeton University 1999 Assistant in Instruction: Introduction to Molecular Biology, Princeton University 1998 Undergraduate Teaching Fellow: High School Biology, Santa Barbara CA 1998

MENTORING EXPERIENCE Advisor: 1 Visiting research fellow working on lab projects, UCLA 2013-2014 Advisor: 2 Postdoctoral fellows working on lab projects, UCLA 2010-2014 Advisor: 3 Ph.D. graduate students working on thesis projects, UCLA 2010-2014 Advisor: 2 M.S. graduate students working on thesis projects, UCLA 2010-2012 Advisor: 1 Staff research associate working on lab projects, UCLA 2010-2014 Advisor: 18 graduate students working on lab rotation projects, UCLA 2009-2014 Advisor: 10 undergraduate students working on lab projects, UCLA 2009-2014 Intern Mentor: Graduate student working on summer internship, Genentech Inc. 2008 Thesis Mentor: Senior working on undergraduate research thesis, Princeton University 2003 Lab Mentor: Graduate student during lab rotation, Princeton University 2003 Preceptor: Introduction to Molecular Biology, Princeton University 2000 Tutor: Advanced biology and chemistry, University of California at Santa Barbara 1997

DIVERSTIY OUTREACH UCLA representative: UC CAMP/LSAMP 2014 University of California, California Alliance for Minority Participation (CAMP) and Lois Stokes Alliance for Minority Participation (LSAMP) Symposium. University of California Irvine

Mentor: UC LEADS 2013 University of California Leadership Excellence through Advanced Degrees (UC LEADS). Mentored undergraduate student during Summer of 2013

Speaker: Project STEPS/ Los Angeles Unified School District (LAUSD) 2013 Parent outreach symposium. STEPS/LAUSD invites students from underrepresented communities, who are interested in science, to UCLA to perform science experiments.

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UCLA representative: UC LEADS 2013 University of California Leadership Excellence through Advanced Degrees (UC LEADS) Research and Leadership Symposium. University of California Santa Cruz

UCLA representative: UC CAMP/LSAMP 2013 University of California, California Alliance for Minority Participation (CAMP) and Lois Stokes Alliance for Minority Participation (LSAMP) Symposium. University of California Irvine

Talk: “Novel drugs in the Treatment of Cancer” 2012 UCLA Bridge Program, purpose is to increase underrepresented minorities (URMs) in the biomedical sciences. Pierce College

Talk: “Small Molecule Inhibitors of Cell Division” 2012 UCLA Summer Program for Undergraduate Research (SPUR), University of California Los Angeles

Panelist: Discussion with underrepresented minority (URM) groups in the sciences. 2012 UCLA Bridge Program, University of California Los Angeles

Talk: “Small Molecule Inhibitors of Cell Division” 2011 UCLA Society for the Advancement of Chicanos and Native Americans in Science (SACNAS), University of California Los Angeles

Talk: “Targeting the Cell Division Machinery in Cancer” 2010 UCLA Minority Access to Research Careers (MARC), University of California Los Angeles

Minority postdoctoral fellow/summer intern recruitment, Genentech Inc 2008

Minority student recruitment, Princeton University Graduate School 2003

OTHER PROFESSIONAL RESPONSIBILITIES Assistant Master: Rockefeller College, Princeton University 2002-2004 Resident Coordinator: Freshman Scholars Institute-Science, Princeton University 2001-2003 Graduate student colloquium organizer, Princeton University 2003

TALKS & POSTERS Talk: “Chemical Dissection of The Cell Cycle” 2014 Cold Springs Harbor Laboratory Cell Cycle Meeting Talk: “Discovery of New Drugs to Combat Cancer” 2014 American Cancer Society Survivor Kickoff Talk: “Integrating Chemical Biology Into Research-based Discovery Learning” 2013 Cottrell Scholar Conference, “Connecting Educators, Building Communities” Talk: “Targeting Cancer Cell Division” 2013 Stanford University School of Medicine, Cancer Cell Biology Program 5 Jorge Torres Ambassador/Talk: “New Drugs to Fight Cancer” 2013 UCLA Bruin Day Talk: “Targeting Cancer Cell Division” 2013 Jonsson Comprehensive Cancer Center Lecture: “Targeting The Cell Division Machinery In Cancer” 2012 UCLA Medical Student Training Program (MSTP) Lecture: “Small Molecule Inhibitors of Cell Division” 2012 UCLA Biomedical Research 5HB Talk: “Novel Anticancer Agents” 2012 Jonsson Comprehensive Cancer Center/TORI Labs Strategic Meeting Talk: “The STARD9 Kinesin is Required for Mitotic Progression” 2012 Cold Springs Harbor Laboratory Cell Cycle Meeting Talk: “Small Molecule Inhibitors of Cell Division” 2012 Trinity University, Chemistry Department Talk: “Targeting the Cell Division Machinery in Cancer” 2012 UCLA Cancer and Stem Cell Program Talk: “Targeting the Cell Division Machinery in Cancer” 2011 UCLA ACCESS Retreat Talk: “Targeting the Cell Division Machinery in Cancer” 2011 UCLA Molecular Biology Institute (MBI) Retreat Talk: “Enzymatic Activities in Cell Division and Cancer” 2011 California State University Los Angeles, Chemistry Department Talk: “PP2A regulates the association of the APC/C with mitotic spindle poles” 2009 EMBO Research Conference Poster: “Proteomic and functional characterization of the mitotic spindle” 2008 ASCB Research Conference Talk: “Identification of KifX, a novel mitotic kinesin necessary for spindle assembly ” 2008 Genentech Postdoctoral Offsite Poster: “PP2A regulates the association of the APC/C with mitotic spindle poles” 2008 Cold Springs Harbor Laboratory Cell Cycle Meeting Poster: “Proteomic and functional characterization of the mitotic spindle” 2007 FASEB Summer Research Conference, Mitosis: Spindle Assembly and Function Poster: “Identification of novel proteins involved in mitotic spindle assembly” 2006 ASCB Research Conference Poster: “Identification of mitotic microtubule associated proteins” 2006 Cold Springs Harbor Laboratory Cell Cycle Meeting Talk: “PP2A regulates the association of the APC/C with mitotic spindle poles” 2005 Genentech Postdoctoral Offsite Poster: “Identification of mitotic microtubule associated proteins” 2005 ASCB Research Conference Talk: “The Rrm3p DNA helicase promotes genomic stability” 2003 Princeton University Molecular Biology Retreat Poster: “Understanding rrm3 sgs1 synthetic sickness in Saccharomyces cerevisiae” 2002 Keystone Research Conference, DNA Helicases, Cancer and Aging Poster: “Understanding rrm3 sgs1 synthetic sickness in Saccharomyces cerevisiae” 2001 FASEB Research Conference, Helicases: Roles in Human Diseases Talk: “Isolation of Telomere Growth Inhibit Forever (TGIF) mutants in T. thermophila” 1998

6 Jorge Torres UCSB Undergraduate Research Colloquium Talk: “Analysis of Telomerase RNA substitution mutants in T. thermophila” 1997 UCSF Summer Research Training Program Talk: “The Tetrahymena thermophila genome project” 1997 UCSB Undergraduate Research Colloquium Talk: “Anthropogenic effects on the sea anemone Anthopleura elegantissima” 1995 UCSB Undergraduate Research Colloquium

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