March–April 2018 Research Bulletin

research AWARDS

Bjorn R. Chia-Yu (Jennifer) Chen, DMD, third Olsen, year DMSc student in periodontology, received MD, PhD, a research award from professor of the Osseointegration Foundation for her developmental research entitled, biology at “Electrophoretic Fusion of Perpendicular HSDM and Type I Collagen into Hersey professor Titanium Nanotube for the Future Peri-Implant Ligament.” The research of cell biology at focuses on utilizing a novel method to modify the HMS, received titanium surface in order to facilitate a biomimetic restoration of peri-implant soft tissue. Chen is an R21 award from NIH-NIAMS entitled, “A working in the Nagai Lab and her research mentor Mechanism for Tyrosine Phosphorylation of is Masazumi Nagai, DDS, PhD, research associate in oral medicine, infection, and immunity at HSDM. Extracellular Matrix Proteins” Additional faculty collaborating on this project include Shigemi Nagai, DDS, PhD and John This study is based on the Olsen Lab Da Silva, DMD, MPH. finding that a secreted kinase variant of the transmembrane-spanning cell surface Harvard China Fund Award fibroblast growth factor receptor kinase In partnership with Associate Dean Jane Barrow, in FGFR2 is expressed in multiple tissues. The the Office of Global and Community Health, Drs. Sang Park and Christine Riedy Murphy received a investigators have made several constructs for grant from the Harvard China Fund. Sang Park, expression of the secreted kinase in cultured MMSc, DMD, associate dean for dental education and associate professor of restorative dentistry cells and they have generated mice that can and biomaterials sciences and Christine Riedy be induced to express the kinase in specific Murphy, PhD, chair and Delta Dental associate professor of oral health policy and epidemiology, cells and tissues. The results of the study have are co-investigators on a recently-funded project the potential for breaking new ground in from The Harvard China Fund. HSDM was awarded a grant to fund a conference to be held October understanding how cells communicate and 2018 at the Harvard Shanghai Center, entitled interact with proteins in their extracellular “Improving Population Health through Oral Health in China: Strengthening the Oral Health matrix environment. Delivery System and Building Workforce Capacity through Innovative Strategies in Education, Care and Research.” STUDENT AWARDS & honors in research

Ali Shazib, Yisi (Daisy) Ji, DMD DMD, DMSc class of 2018, will receive student in oral honors in research when she medicine, received graduates in May. Ji has been a resident research involved in numerous research award from projects leading to twelve the American publications. Her honors project, Academy of “Management of Benign Oral Medicine, Pathology” was completed for his research under the mentorship of Zachary entitled, “Toxicity Profile and Cost- Peacock, DMD, MD, associate Analysis of a Young and Low-Risk professor of oral and maxillofacial surgery at HSDM. Cohort of Oral Cavity Squamous Cell After graduation, Ji will join the residency program in Carcinoma Patients.” Shazib’s research the Department of Oral and Maxillofacial Surgery at mentor is Alessandro Villa, DDS, PhD, Massachusetts General Hospital. MPH, assistant professor of oral medicine, infection, and immunity at HSDM, and associate surgeon in the Division of Oral Carolynn T. Vuong, DMD Medicine and Dentistry at Brigham and class of 2018, will receive honors Women’s Hospital. in research when she graduates in May. Her honors project, “Sealed Primary Molars are Less R. Frederick Likely to Develop Caries” was Lambert, DMD completed under the mentorship class of 2018, will of Rosalyn Sulyanto, DMD, receive honors instructor in developmental in research when biology at HSDM. After he graduates in graduation, Vuong will join the May. His honors residency program in the Pediatric Dentistry Division at project, “Factors the University of California, San Francisco. That Motivate Otherwise Healthy Young Adults Living with HIV Stephanie Lee, DMD class to Access and Utilize HIV Services of 2018, will receive honors in and Dental Services in Gugulethu, research when she graduates South Africa” was completed under in May. Her honors project, “A the mentorship of Jessica Haberer, MD, Vibration Device to Control associate professor of medicine and Injection Discomfort” was director of global health research at completed under the mentorship Massachusetts General Hospital and of Jeffry Shaefer, DMD, Catherine Orrell, PhD, associate professor assistant professor in oral and at the University of Cape Town Desmond maxillofacial surgery at HSDM. Tutu HIV Centre. After graduation, After graduation, Lee will join Lambert will pursue a master’s degree in the residency program at the Veteran’s Administration of public health at the Harvard T. H. Chan Northern California Health Care System. School of Public Health.

2 Research Bulletin • March – April 2018 • Harvard School of Dental Medicine STUDENT AWARDS & honors in research Oral Oncology Nisarg Fellowship at HSDM Patel, DMD class of 2018, received first place in the clinical science and

public health The objective of the proposed fellowship program is to research provide in-depth, focused training for community dentists so category for that they are adequately prepared to manage cancer patients Dentsply Sirona and the American before, during, and after cancer treatment. The program will Association for Dental Research contribute to an overall improvement in community health Student Competition for Advancing by increasing the knowledge, ability, and engagement of the Dental Research and Its Application general practitioner. Graduates of the fellowship program will (SCADA). Patel’s research is entitled, be expected to serve as community experts, providing a critical “A Medical Bundled Payment resource for oncologists, dentists, and cancer patients. Model Integrating Dental Care May Reduce Emergency Department Costs.” Patel’s research mentor is The Oral Oncology Fellowship Program is a one year, full- Salim Afshar, DMD, MD, instructor time training program for dentists who are committed to in oral and maxillofacial surgery at developing expertise in oncology and oral health and serving HSDM, and attending surgeon in oral as community leaders. Candidates must possess a DMD, DDS, and maxillofacial surgery at Boston or equivalent degree. Completion of a hospital-based general Children’s Hospital. practice residency (GPR) or equivalent is preferred. Applicants from countries in which English is not the primary language Nisarg Patel is photographed below must provide an official Test of English as a Foreign Language presenting his HSDM Student (TOEFL) score report. Research Day project to Deepti Shroff, DMD class of 2019, who received Trainees are appointed at HSDM, BWH, and DFCI. Clinical the 2018 SCADA Award (please see training is based at BWH and DFCI with additional rotations at description on page 6). other Harvard affiliated teaching hospitals as well as community health centers. Salary and benefits will be commensurate with HSDM Fellow Salary Scale. HSDM will offer one fellowship position per year. The admissions committee takes into account academic performance during dental school, personal statement, letters of recommendation, research experience, extracurricular activities, and prior postdoctoral clinical experience.

Oral Oncology Fellowship applications are due June 2018. Select candidates are invited for a mandatory interview in July 2018, and the Fellowship start date is October 2018. For additional information about the admissions process, please contact ([email protected]) or 617-432-1443. The Program Director is Alessandro Villa, DDS, PhD, MPH.

Research Bulletin • March – April 2018 • Harvard School of Dental Medicine 3 new research investigators

Emily Moore, MS, PhD, Corneliu Sima, joined the Yang Lab as a research DMD, DSc, MSc, fellow in the Department of has been appointed as Developmental Biology. Moore assistant professor in comes from Massillon, Ohio and the Department of Oral received her BS and MS degrees Medicine, Infection, in biomedical engineering from and Immunity at Case Western Reserve University. HSDM. Sima earned his For her master’s degree, Moore DMD degree in 2006 from worked in the Tissue Fabrication the University of Medicine and Mechanobiology Lab at Case and Pharmacy Cluj-Napoca in Romania. He Western Reserve University with Dr. Ozan Akkus where went on to study at the Boston University she built a custom device to test the fatigue life of bone Goldman School of Dental Medicine, earning specimens. She received her PhD degree in biomedical a DSc in oral biology and periodontology engineering from Columbia University where she worked in 2010. He then received an MSc degree in the Cell and Molecular Biomechanics Lab in the in periodontology from the University of Department of Biomedical Engineering with Dr. Chris Toronto in 2014 and was clinical instructor Jacobs. In the Yang Lab, Moore will create transgenic in periodontology from 2011–2014. In 2015, animal models to investigate the role of Wnt and Hippo Sima joined the Forsyth Institute as an assistant signaling in osteogenic precursors and dental pulp stem clinical investigator, with an appointment in oral cells with regards to their ability to become bone-forming medicine, infection, and immunity at HSDM cells. as a research fellow. Sima’s research focus is on joined the Yang Lab as translational investigation on the pathogenesis Bo Gao, of type 2 diabetes and periodontitis, and on a visiting graduate student in the developing therapeutic means to modulate Department of Developmental de-regulated inflammatory responses to Biology. Gao is an MD/PhD subgingival biofilms. candidate in spine surgery at Sun Yat-Sen University and the Sun Yara Halasa- Yat-Sen Memorial Hospital in Guangdong, China. In the Yang Rappel, DDS, MS, Lab, Gao will focus on studying the MA, PhD, a dentist, underlying genetic and pathogenic health economist, mechanism of scoliosis and the molecular investigation of and policy analyst, spine development. has been appointed as research fellow in the Department of Zhenhua Gao, DDS, PhD, Oral Health Policy joined the Ionescu Lab as a and Epidemiology visiting graduate student in the at HSDM. Prior to joining HSDM, Halasa- Department of Developmental Rappel was a senior research associate at Biology. Gao received his DDS the Schneider Institutes for Health Policy at from Weifang Medical University Brandeis University. She has over fourteen years in Shandong, China and his PhD of experience conducting research on health in Oral Maxillofacial Surgery financing, costing of health care services, cost from Capital Medical University of illness, modeling, economic evaluation of in Beijing, China. Gao’s previous health and health-related projects, and cost- research focused on tooth development and regeneration. effectiveness with a special focus on dengue, In the Ionescu Lab, Gao will focus on temproal mandibular malaria, and oral health. Halasa-Rappel has a joint development and jaw bone regeneration using several PhD in health policy from Brandeis University gene-modified mouse models. and has authored forty publications.

4 Research Bulletin • March – April 2018 • Harvard School of Dental Medicine Oral Medicine, Infection, and Immunity HSDM Publications Almazyad A, Li C, Tapia R, Robertson J, Collette D, Woo SB. Primordial odontogenic tumour: Report of two cases. Developmental Biology Histopathology 2018 Feb 19. Chalmers N, Wislar J, Hall M, Thurm C, Ng MW. Trends in pediatric dental care use. Dental Clinics of North America Bachour P, Sonis S. Predicting mucositis risk associated with 2018; 62(2):295-317.e12. cytotoxic cancer treatment regimens: rationale, complexity, and challenges. Current Opinions in Supportive Palliative Gao B, Ajima R, Yang W, Li C, Song H, Anderson M, Liu Care 2018; Mar 14. R, Lewandoski M, Yamaguchi T, Yang Y. Coordinated directional outgrowth and pattern formation by integration Belstrøm D, Grande M, Sembler-Møller M, Kirkby N, of Wnt5a and Fgf signaling in planar cell polarity. Cotton S, Paster B, Holmstrup P. Influence of periodontal Development 2018; Apr 3. treatment on subgingival and salivary microbiotas. Journal of Periodontology 2018; Feb 19. Lowery J, Rosen V. Bone morphogenetic protein-based therapeutic approaches. Cold Spring Harbor Perspectives in Elad S, Zinchuk K, Li S, Cutler C, Liesveld J, Treister N. Biology 2018;10(4). Economic and practical considerations in the treatment of oral mucosal chronic graft-versus-host disease. Biology of Niwa T, Yamakoshi Y, Yamazaki H, Karakida T, Chiba R, Blood and Marrow Transplantation 2018; Mar 1. Hu J, Nagano T, Yamamoto R, Simmer J, Margolis H, Gomi K. The dynamics of TGF-β in dental pulp, odontoblasts and Fan Y, Liu W, Bi R, Densmore M, Sato T, Mannstadt M, dentin. Scientific Reports 2018; 8(1):4450. Yuan Q, Zhou X, Olauson H, Larsson T, Toka H, Pollak M, Brown E, Lanske B. Interrelated role of Klotho and Oral and Maxillofacial Surgery calcium-sensing receptor in parathyroid hormone synthesis Ji Y, Lahey E. Conflicts of interest in clinical guidelines: Lack and parathyroid hyperplasia. Proceedings of the National of authors and disclosures in the AAOMS white papers. Academy of Sciences of USA 2018; Apr 4. Journal of Oral and Maxillofacial Surgery 2018; Mar 2. Movila A, Kajiya M, Wisitrasameewong W, Stashenko P, Resnick C, Daniels K, Vlahos M. Does Andrews facial Vardar-Sengul S, Hernandez M, Thomas Temple H, Kawai T. analysis predict esthetic sagittal maxillary position? Oral Intravital endoscopic technology for real-time monitoring of Surgery Oral Medicine Oral Pathology Oral Radiology 2018; inflammation caused in experimental periodontitis. Journal Feb 1. of Immunological Methods 2018; Mar 19.

Resnick C, Kooiman T, Calabrese C, Didier R, Padwa B, Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan Estroff J, Koudstaal M. In utero glossoptosis in fetuses with C, Van Dyke T. Author Correction: ERV1 overexpression in Robin squence: Measurements from prenatal MRI. Cleft myeloid cells protects against high fat diet induced obesity Palate-Craniofacial Journal 2018;55(4):562-567. and glucose intolerance. Scientific Reports 2018; 8(1):4143.

Resnick C, Kooiman T, Calabrese C, Zurakowski D, Padwa Villa A, Sonis S. Oral leukoplakia remains a challenging B, Koudstaal M, Estroff J. An algorithm for predicting Robin condition. Oral Diseases 2018;24(1-2):179-183. sequence from fetal MRI. Prenatal Diagnostics 2018; Feb 19. Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, Han Resnick C, Pedersen T, Abramowicz S, Twilt M, Stoustrup P. X, Tang G. Increased infiltration of CD11 c^{+/CD123+ dendritic cell subsets and joint in juvenile idiopathic arthritis. Journal of Oral and upregulation of TLR/IFN-α signaling participate in Maxillofacial Surgery 2018; Feb 26. pathogenesis of oral lichen planus. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2017; Dec 18. Stoustrup P, Iversen C, Kristensen K, Resnick C, Verna C, Nørholt S, Abramowicz S, Küseler A, Cattaneo P, Herlin Yeh S, Wilk K, Lin C, Intini G. In vivo 3D histomorphometry T, Pedersen T. Assessment of dentofacial growth deviation quantifies bone apposition and skeletal progenitor cell in juvenile idiopathic arthritis: Reliability and validity of differentiation. Scientfic Reports 2018; 8(1):5580. three-dimensional morphometric measures. PLoS One 2018;13(3):e0194177. Oral Health Policy and Epidemiology Aherne J, Hamnvik O, Barrow J, Nunn J. Incorporating Restorative Dentistry and Biomaterials oral health as part of routine diabetes care in Ireland. Irish Medical Journal 2017;110(10):660. Sciences Nokar S, Sadighpour L, Shirzad H, Shahrokhi Rad A, Helmi M, Spinella M, Seymour B. Community water Keshvad A. Evaluation of signs, symptoms, and occlusal fluoridation online: an analysis of the digital media factors among patients with temporomandibular disorders ecosystem. Jouranl of Public Health Dentistry 2018; Mar 30. according to Helkimo index. Cranio 2018; Mar 30;1-6.}

Research Bulletin • March – April 2018 • Harvard School of Dental Medicine 5 Multi-Departmental Bassir S, Chase I, Paster B, Gordon L, Kleinman M, Kieran Deepti Shroff, M, Kim D, Sonis A. Microbiome at sites of gingival recession in children with Hutchinson-Gilford progeria syndrome. DMD class of 2019, Journal of Periodontology 2018; Feb 19. received the 2018 Candamo F, Tobey M, Simon L. Teaching dental students American Dental about incarceration and correctional dentistry: Results Association/Dentsply from a national survey. Journal of Dental Education 2018;82(3):299-305. Student Clinician Research Program Fortier K, Shroff D, Reebye U. Review: An overview and Award. analysis of novel oral anticoagulants and their dental implications. Gerodontology 2018; Feb 28. Shroff has been active in numerous research projects Ishii T, Ruiz-Torruella M, Ikeda A, Shindo S, Movila A, including one at Boston Children’s Hospital with Mawardi H, Albassam A, Kayal R, Al-Dharrab A, Egashira K, Wisitrasameewong W, Yamamoto K, Mira A, Sueishi K, Dr. Rosalyn Sulyanto, instructor in developmental Han X, Taubman M, Miyamoto T, Kawai T. OC-STAMP biology, to assess parental perception and acceptance promotes osteoclast fusion for pathogenic bone resorption of silver diamine fluoride. This project was funded in periodontitis via up-regulation of permissive fusogen by the Samuel D. Harris Fund for Children’s Dental CD9. FASEB Journal 2018; Mar 13. Health. Shroff also worked with Dr. Sang Park and Jamjoom F, Lee D. Modification of clinically short locator colleagues on a project that was published in the abutments using laser welding. Journal of Prosthetic Journal of Dental Education entitled, “A Reflection Dentistry 2018; Feb 8. Curriculum for Longitudinal Community-Based Lambert R, Wong C, Woodmansey K, Rowland B, Horne Clinical Experiences: Impact on Student Perceptions S, Seymour B. A national survey of U.S. dental students’ of the Safety Net.” Additionally, Shroff worked on a experiences with international service trips. Journal of project at Massachusetts General Hospital with Dr. Dental Education 2018;82(4):366-372. Katherine Klein, instructor in oral and maxillofacial Lee C, Kobayashi H, Lee S, Ohyama H. The role of digital surgery and Dr. David Keith, professor of oral and 3D scanned models in dental students’ self-assessments in maxillofacial surgery, evaluating the outcomes of TJR/ preclinical operative dentistry. Journal of Dental Education orthognathic surgeries. Her research has resulted in 2018;82(4):399-405. four publications and several abstract presentations. Park S, Price M, Karimbux N. The dental school interview as The American Dental Association/Dentsply Student a predictor of dental students’ OSCE performance. Journal of Clinician Research Program Award will support Shroff Dental Education 2018;82(3):269-276. in attending and presenting her research at the next Resnick C, Partridge J, Dang R, Burashed H, Padwa B, American Dental Association annual meeting. Mulliken J. Augmentation of the median tubercle with dermis-fat graft in children with repaired cleft lip. Plastic and Reconstructive Surgery 2018;141(4):540e-546e.

Yoon H, Sohn P, Jin S, Hawazin E, Lee S. Fracture resistance A publication of the of CAD/CAM-fabricated lithium disilicate MOD inlays and onlays with various cavity preparation designs. Journal of Office of Research Prosthodontics 2018; Mar 13. 188 Longwood Avenue ­ Zhao N, Cao J, Xu L, Tang Q, Dobrolecki L, Lv X, Talukdar Boston, MA 02115 M, Lu Y, Wang X, Hu D, Shi Q, Xiang Y, Wang Y, Liu X, www.hsdm.harvard.edu Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng X, Hartig S, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson J, Kaipparettu B, Putluri N, Sicheri F, Rosen Malcolm Whitman, PhD, Interim Dean for Research J, Lewis M, Chen X. Pharmacological targeting of MYC- Dawn M. DeCosta, Editor and Layout regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. Journal of Clinical Investigation 2018; Feb 26. Heather M. Denny, Editing Leanne Jacobellis, Editing Amy Fenton, Editing

6 Research Bulletin • March – April 2018 • Harvard School of Dental Medicine