(12) Patent Application Publication (10) Pub. No.: US 2014/0031308A1 Diane Et Al
US 2014003 1308A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0031308A1 Diane et al. (43) Pub. Date: Jan. 30, 2014 (54) BENCHMARKS FOR NORMAL CELL on Feb. 8, 2011, provisional application No. 61/469, IDENTIFICATION 812, filed on Mar. 31, 2011. (76) Inventors: Longo Diane, Foster City, CA (US); Todd M. Covey, San Carlos, CA (US); Publication Classification David M. Soper, San Francisco, CA (US); Garry P. Nolan, San Francisco, (51) Int. C. CA (US); Alessandra Cesano, Redwood GOIN33/50 (2006.01) city, CA (US) G06F 9/72 (2006.01) (52) U.S. C. (21) Appl. No.: 13/821,539 CPC ............ G0IN33/5008 (2013.01); G06F 19/12 PCT Fled: Sep. 8, 2011 (2013.01) (22) USPC ...... 514/43; 435/29: 435/7.21: 703/11: 703/2 (86) PCT NO.: PCT/US11?01565 S371 (c)(1), (57) ABSTRACT (2), (4) Date: Oct. 2, 2013 Provided herein are methods, compositions, and kits for Related U.S. Application Data determining cell signaling profiles in normal cells and com (60) Provisional application No. 61/381,067, filed on Sep. paring the cell signaling profiles of normal cells to cell sig 8, 2010, provisional application No. 61/440,523, filed naling profiles from a test sample. Patent Application Publication Jan. 30, 2014 Sheet 1 of 37 US 2014/0031308A1 2 in 2d (2d 20 (2d 2 (2 (2d 2 on 33 it 33 Ée 38 it 38 St 38 is 38 St 38 is 33 38,. 38.H. 33. 38. g. .38. ; isSSSOC or SSSOCstor SSSOCis us SSSOOis or SSSOCis or SSSOCis or SSOCis or SSCOis of CSSSSSSSSSSSSSSSSSSSSSgo go 599 go go 399 go go 5992 q) q) 59.9 g g 599 Egg) as 99.2 g g 5992 gld go 599.
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