DOCSLIB.ORG

Us 2018 / 0344582 A1

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Us 2018 / 0344582 A1 US 20180344582A1 ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2018 /0344582 A1 Kim et al. ( 43 ) Pub . Date : Dec . 6 , 2018 ( 54 ) PREPARATION FOR ATTACHING TO Publication Classification TEETH OR SURROUNDING PART OF (51 ) Int. Ci. TEETH A61K 8 / 02 (2006 . 01 ) A61K 8 / 73 ( 2006 .01 ) ( 71 ) Applicant: LG Household & Health Care Ltd . , A61K 8 / 25 ( 2006 .01 ) Seoul (KR ) A61K 8 /69 ( 2006 .01 ) A61K 8 /81 (2006 .01 ) ( 72 ) Inventors : Ji - Young Kim , Daejeon (KR ); A610 11 /00 ( 2006 .01 ) Jae - Hyun Ahn , Daejeon (KR ) ; 2) U . S . CI. Jong -Hoon Kim , Daejeon (KR ) ; In - Ho CPC .. .. .. .. .. A61K 8 /02 ( 2013 . 01 ) ; A61K 8 / 736 Lee , Daejeon (KR ) ; Sang- Min Lee , ( 2013 .01 ) ; A61K 8 / 25 ( 2013 .01 ) ; A61K 9 / 70 Daejeon (KR ) ( 2013 .01 ) ; A61K 8 /69 ( 2013 .01 ) ; A61K 8 /81 ( 2013. 01 ); A61Q 11/ 00 ( 2013 .01 ) ; A61K 8 / 731 ( 73 ) Assignee : LG Household & Health Care Ltd . , (2013 .01 ) Seoul (KR ) (57 ) ABSTRACT The present invention provides a preparation for attaching to ( 21 ) Appl. No. : 15 / 778, 127 teeth or tooth peripheries, which comprises a malleable oral composition and an active ingredient for intra -oral delivery . ( 22 ) PCT Filed : Nov. 10 , 2016 Further, the present invention provides a preparation for attaching to teeth or tooth peripheries , which comprises an ( 86 ) PCT No. : PCT/ KR2016 /012934 oral composition in a hardening ointment -phase and an $ 371 ( c ) ( 1 ) , active ingredient for intra - oral delivery . The preparation of ( 2 ) Date : May 22 , 2018 the present invention may give high adhesive force to the desired site in spite of gaps between teeth or curves of teeth . (30 ) Foreign Application Priority Data The preparation of the present invention having high adhe sive force increases the time of adhesion to a target site in Nov. 24 , 2015 (KR ) . .. .. .. 10 -2015 -0164928 the oral cavity , and thus may be advantageous in achieving Dec. 3 , 2015 ( KR ) . .. .. .. .. 10 - 2015 - 0171541 an intended effect. tsar that JH heb. com Patent Application Publication Dec . 6 , 2018 Sheet 1 of 4 US 2018 /0344582 A1 FIG . 1 ( a ) . 12. 1911 TL11 - - - - - - ( b ) Patent Application Publication Dec . 6 , 2018 Sheet 2 of 4 US 2018 /0344582 A1 FIG . 2 : : . : . : : : : il ' ii .Vinttiiliopew : : : :: . : : IIIIIII firinin k iinni . ! . i ' Tilisi. iiiiiiii. i . n . 1 1 I . III I . : Iniis rii , , SHI . i i . is riiulisi . i . Ini . iiii . ii . : : : 1 . Nii , ' , AVITY . .I . II i II : : . I . '.. .. : . : . S ! ! ! . : ' ! . .1 . : . ADA ? . Fy - . Showing ?? . Patent Application Publication Dec . 6 , 2018 Sheet 3 of 4 US 2018 /0344582 A1 FIG . 3 Patent Application Publication Dec . 6 , 2018 Sheet 4 of 4 US 2018/ 0344582 A1 FIG . 4 , ," ? . ? - . ? ? ? ? ? ? , , , • • ' ' ' ' . ' .' ,' IT ' ' ' . ' . ' ' ' . ' ' . ' ? ? ? ? ' ' ' ' ? ' ' ? . thorn" / US 2018 /0344582 A1 Dec. 6 , 2018 PREPARATION FOR ATTACHING TO SUMMARY OF THE INVENTION TEETH OR SURROUNDING PART OF [0008 ] In order to solve the above problems, the present TEETH invention provides a preparation for delivering an active CROSS -REFERENCE TO RELATED ingredient whose physical properties are changed before attachment to teeth and after a period of time after the APPLICATIONS attachment. [0001 ] The present application claims priority to Korean [ 0009 ] Further , the present invention provides a prepara Patent Application No . 10 - 2015 - 0164928 filed on Nov . 24 , tion in a form that can be freely changed before use , and can 2015 , and Korean Patent Application No . 10 - 2015 -0171541 be adhered well to gaps between teeth or a boundary area filed on Dec . 3 , 2015 in the Republic of Korea , the disclo between gums and teeth . sures of which are incorporated herein by reference . [0010 ) Further, the present invention provides a novel form of an oral preparation having excellent feeling of use , TECHNICAL FIELD which can be conveniently used without any feeling of being [0002 ] The present invention relates to a preparation for stained or sticky in the hands when attached to teeth or tooth delivering a drug into the oral cavity , and more specifically, peripheries . it relates to a novel form of an oral preparation , which can [ 0011] These and other objects and advantages of the effectively deliver an active ingredient to the desired site in present invention may be understood from the following the oral cavity . detailed description and will become more fully apparent from the exemplary embodiments of the present invention . Also , it will be easily understood that the objects and BACKGROUND OF THE INVENTION advantages of the present invention may be realized by the [ 0003 ] In order to deliver an oral active ingredient into the means shown in the appended claims and combinations oral cavity , the contact time with an active ingredient and the delivery amount play an important role . thereof. [ 00041 Paste formulations such as toothpaste have a dis Definition advantage that it is difficult to provide sufficient contact time at the target site due to insufficient viscosity and high [0012 ]. The term “ tooth peripheries ' used herein is gener solubility , and mouth trays intended for intraoral drug deliv ally a concept involving a region represented by gums, and ery have a disadvantage that they have a strong sense of may be used to mean including all of the mucosal regions foreign body and difficult to deliver a drug locally due to around teeth . The tooth peripheries can be used to mean their shape characteristics. Patch type or strip type is thin , so covering the region where an active ingredient for intra - oral it is difficult to deliver sufficient amount of an active delivery can be delivered together with the teeth when the ingredient, and flexibility is low , so there is a disadvantage preparation is applied to the teeth in the structure of the that it is difficult to be adhered to gaps between teeth , preparation . Herein , teeth or tooth peripheries ' is used boundary area between gums and teeth , and the like . together with ' teeth ' , and it may be understood herein to 0005 ] In order to solve the adhesion problem to the gaps include both the teeth and the tooth peripheries even if it is between teeth , boundary area between gums and teeth and described only as ' teeth ' . the like , Korean Patent No . 10 - 0623859 developed a deliv [ 0013 ] The term “oral composition in a hardening oint ery system for a tooth whitening component using in situ ment- phase ' used herein means an oral composition that gelling , but there was a disadvantage that it is necessary to does not have a certain shape before adhered to teeth , has an use a separate backing layer because it is highly flowable ointment phase of free - shape transformation , gradually loses when applied to the tooth surface. Further, WO 2003 / 037276 its fluidity , and its shape is fixed . Namely , it means an discloses a preparation to be sprayed in the oral cavity due ointment- type oral composition , which has a characteristic to its low initial viscosity , but there was a problem that the that the preparation of the present invention is ointment type difference between the normal storage temperature ( espe when the preparation is applied to teeth or tooth peripheries , cially in summer ) and the temperature in the oral cavity is after application , its viscosity increases up to the point of small and it is difficult to remove it because the phase adhesion , and it hardens at the point when it is removed from transition does not occur rapidly unless it is applied very teeth after adhesion . thin . [0014 ] The ‘hardening ointment - phase preparation may [0006 ] U . S . Pat . No . 5 , 989, 569 discloses about applying a mean a preparation that is a semi- solid - type ointment such drug to the surface of a strip and delivering the drug by as dough or clay after application , but is molded with pressure , but there were problems that the active ingredient external force such as heat or pressure over time, gradually is temporarily released because the drug is applied on the loses its moldability and hardens, and finally permanently surface of the strip and adhered to teeth as it is , and it may transformed . cause strong stimulus in the gums around the teeth . Further , [0015 ] The term “hardening ' used herein may include not there was a disadvantage that physical properties , in par only hardening by the formation of a network structure such ticular , flexibility , of the drug to be applied are different from as an ionic crosslinked structure like an egg - box model but those of the strip , and therefore , adhesion to gaps between also a decrease in fluidity accompanied by a progress of teeth is difficult . polymerization reaction by light or a catalyst , and may mean [0007 ] The inventors of the present invention have studied a state of hardly hardening due to various factors such as for a long time to develop a novel form of a preparation , degree of absorption of water and degree of exposure to air, which can effectively deliver a drug into the oral cavity with and no further shape transformation . convenience of use , thereby completing the present inven [0016 ] The term “malleability ' used herein may mean that tion . the preparation of the present invention has shape trans US 2018 /0344582 A1 Dec. 6 , 2018 formability or can have moldability by external pressure . It preferably about 1 to 3 min or less after applying the also mean that the preparation is sufficiently flexible and it preparation of the present invention to teeth . is possible to transform to such a degree that when the [0024 ] The term “ timeof removal ofthe preparation ' in the preparation is adhered in the mouth , it can be completely present invention may mean the time that the drug is adhered to gaps between teeth or the fine portion between released from the oral cavity after it is adhered to teeth or a teeth and gums.
Load more

Recommended publications
  • Antiseptics and Disinfectants for the Treatment Of
    Verstraelen et al. BMC Infectious Diseases 2012, 12:148 http://www.biomedcentral.com/1471-2334/12/148 RESEARCH ARTICLE Open Access Antiseptics and disinfectants for the treatment of bacterial vaginosis: A systematic review Hans Verstraelen1*, Rita Verhelst2, Kristien Roelens1 and Marleen Temmerman1,2 Abstract Background: The study objective was to assess the available data on efficacy and tolerability of antiseptics and disinfectants in treating bacterial vaginosis (BV). Methods: A systematic search was conducted by consulting PubMed (1966-2010), CINAHL (1982-2010), IPA (1970- 2010), and the Cochrane CENTRAL databases. Clinical trials were searched for by the generic names of all antiseptics and disinfectants listed in the Anatomical Therapeutic Chemical (ATC) Classification System under the code D08A. Clinical trials were considered eligible if the efficacy of antiseptics and disinfectants in the treatment of BV was assessed in comparison to placebo or standard antibiotic treatment with metronidazole or clindamycin and if diagnosis of BV relied on standard criteria such as Amsel’s and Nugent’s criteria. Results: A total of 262 articles were found, of which 15 reports on clinical trials were assessed. Of these, four randomised controlled trials (RCTs) were withheld from analysis. Reasons for exclusion were primarily the lack of standard criteria to diagnose BV or to assess cure, and control treatment not involving placebo or standard antibiotic treatment. Risk of bias for the included studies was assessed with the Cochrane Collaboration’s tool for assessing risk of bias. Three studies showed non-inferiority of chlorhexidine and polyhexamethylene biguanide compared to metronidazole or clindamycin. One RCT found that a single vaginal douche with hydrogen peroxide was slightly, though significantly less effective than a single oral dose of metronidazole.
    [Show full text]
  • Tonsillopharyngitis - Acute (1 of 10)
    Tonsillopharyngitis - Acute (1 of 10) 1 Patient presents w/ sore throat 2 EVALUATION Yes EXPERT Are there signs of REFERRAL complication? No 3 4 EVALUATION Is Group A Beta-hemolytic Yes DIAGNOSIS Streptococcus (GABHS) • Rapid antigen detection test infection suspected? (RADT) • roat culture No TREATMENT EVALUATION No A Supportive management Is GABHS confi rmed? B Pharmacological therapy (Non-GABHS) Yes 5 TREATMENT A EVALUATE RESPONSEMIMS Supportive management TO THERAPY C Pharmacological therapy • Antibiotics Poor/No Good D Surgery, if recurrent or complicated response response REASSESS PATIENT COMPLETE THERAPY & REVIEW THE DIAGNOSIS© Not all products are available or approved for above use in all countries. Specifi c prescribing information may be found in the latest MIMS. B269 © MIMS Pediatrics 2020 Tonsillopharyngitis - Acute (2 of 10) 1 ACUTE TONSILLOPHARYNGITIS • Infl ammation of the tonsils & pharynx • Etiologies include bacterial (group A β-hemolytic streptococcus, Haemophilus infl uenzae, Fusobacterium sp, etc) & viral (infl uenza, adenovirus, coronavirus, rhinovirus, etc) pathogens • Sore throat is the most common presenting symptom in older children TONSILLOPHARYNGITIS 2 EVALUATION FOR COMPLICATIONS • Patients w/ sore throat may have deep neck infections including epiglottitis, peritonsillar or retropharyngeal abscess • Examine for signs of upper airway obstruction Signs & Symptoms of Sore roat w/ Complications • Trismus • Inability to swallow liquids • Increased salivation or drooling • Peritonsillar edema • Deviation of uvula
    [Show full text]
  • Report Name:Ukraine's Mrls for Veterinary Drugs
    Voluntary Report – Voluntary - Public Distribution Date: November 05,2020 Report Number: UP2020-0051 Report Name: Ukraine's MRLs for Veterinary Drugs Country: Ukraine Post: Kyiv Report Category: FAIRS Subject Report Prepared By: Oleksandr Tarassevych Approved By: Robin Gray Report Highlights: Ukraine adopted several maximum residue levels (MRLs) for veterinary drugs, coccidiostats and histomonostats in food products of animal origin. Ukraine also adopted a list of drugs residues that are not allowed in food products. THIS REPORT CONTAINS ASSESSMENTS OF COMMODITY AND TRADE ISSUES MADE BY USDA STAFF AND NOT NECESSARILY STATEMENTS OF OFFICIAL U.S. GOVERNMENT POLICY The Office of Agricultural Affairs of USDA/Foreign Agricultural Service in Kyiv, Ukraine prepared this report for U.S. exporters of domestic food and agricultural products. While every possible care was taken in the preparation of this report, information provided may not be completely accurate either because policies have changed since the time this report was written, or because clear and consistent information about these policies was not available. It is highly recommended U.S. exporters verify the full set of import requirements with their foreign customers, who are normally best equipped to research such matters with local authorities, before any goods are shipped. This FAIRS Subject Report accompanies other reports on Maximum, Residue Limits established by Ukraine in 2020. Related reports could be found under the following links: 1.) Ukraine's MRLs for Microbiological Contaminants_Kyiv_Ukraine_04-27-2020 2.) Ukraine's MRLs for Certain Contaminants_Kyiv_Ukraine_03-06-2020 Food Products of animal origin and/or ingredients of animal origin are not permitted in the Ukrainian market if they contain certain veterinary drugs residues in excess of the maximum residue levels established in Tables 1 and 2.
    [Show full text]
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
    [Show full text]
  • Unduh File PDF
    Majalah Farmasetika, 3 (5) 2018, 98-101 https://doi.org/10.24198/farmasetika.v3i5.21633 e-ISSN : 2686-2506 Perkembangan Obat Sariawan dan Terapi Alternatifnya Prilly Mutiara Sandy*, Fira Burhanisa Irawan Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Padjadjaran, Sumedang 45363 email: [email protected] Abstrak : Sariawan merupakan penyakit mulut yang sudah tidak asing lagi. Berbagai kalangan mulai dari balita, remaja, orang tua, maupun lanjut usia tentu pernah mengalami penyakit tersebut. Efek dari sariawan itu sendiri ialah bisa menyebabkan para penderitanya tidak nafsu makan dan mulut terasa perih. Pengobatan yang dapat dilakukan adalah dengan mengonsumsi zat pemati rasa dan antiseptika.Pemakaiannya obat bisa dilakukan sebanyak 2-3 kali dalam sehari. Selain dengan zat pemati rasa, sariawan juga dapat diobati dengan antiseptika. Hasil terbaik dari penggunaan antiseptika terbukti oleh obat kumur provid-ion (Betadine) dan klorheksidin dalam bentuk tablet hisap srta larutan peroksida 3%. Selain itu juga bisa menggunakan obat kumur yang mengandung Chlorhexidine gluconate 2%, sodium hyaluronate, PVP , dan glycyrrhetinic. BPOM menganjurkan penggunaan obat-obat yang memiliki kandungan enzydamine HCL, providone iodine 1%, atau kombinasi dequalinium chloride dan vitamin C. Bagi yang ingin menyembuhkan sariawan dengan bahan-bahan alami, yaitu: tanaman gambir, daun sirih, air garam, dan cabai. Keyword : obat, sariawan, terapi alternative Outline • Pendahuluan • Terapi sariawan • Albothyl (policresulen) • Terapi alternatif • Kesimpulan Pendahuluan Sariawan atau aphtous stomatitis adalah luka yang terdapat di dalam mulut yang biasanya berbentuk oval atau bulat berwarna putih dan dapat menimbulkan rasa tidak sakit serta tidak nyaman. Sariawan disebabkan oleh beberapa hal, diantaranya ialah kurangnya vit C, vit B12 dan bisa juga karena adanya infeksi yang disebabkan oleh bakteri, virus, atau jamur.
    [Show full text]
  • Vr Meds Ex01 3B 0825S Coding Manual Supplement Page 1
    vr_meds_ex01_3b_0825s Coding Manual Supplement MEDNAME OTHER_CODE ATC_CODE SYSTEM THER_GP PHRM_GP CHEM_GP SODIUM FLUORIDE A12CD01 A01AA01 A A01 A01A A01AA SODIUM MONOFLUOROPHOSPHATE A12CD02 A01AA02 A A01 A01A A01AA HYDROGEN PEROXIDE D08AX01 A01AB02 A A01 A01A A01AB HYDROGEN PEROXIDE S02AA06 A01AB02 A A01 A01A A01AB CHLORHEXIDINE B05CA02 A01AB03 A A01 A01A A01AB CHLORHEXIDINE D08AC02 A01AB03 A A01 A01A A01AB CHLORHEXIDINE D09AA12 A01AB03 A A01 A01A A01AB CHLORHEXIDINE R02AA05 A01AB03 A A01 A01A A01AB CHLORHEXIDINE S01AX09 A01AB03 A A01 A01A A01AB CHLORHEXIDINE S02AA09 A01AB03 A A01 A01A A01AB CHLORHEXIDINE S03AA04 A01AB03 A A01 A01A A01AB AMPHOTERICIN B A07AA07 A01AB04 A A01 A01A A01AB AMPHOTERICIN B G01AA03 A01AB04 A A01 A01A A01AB AMPHOTERICIN B J02AA01 A01AB04 A A01 A01A A01AB POLYNOXYLIN D01AE05 A01AB05 A A01 A01A A01AB OXYQUINOLINE D08AH03 A01AB07 A A01 A01A A01AB OXYQUINOLINE G01AC30 A01AB07 A A01 A01A A01AB OXYQUINOLINE R02AA14 A01AB07 A A01 A01A A01AB NEOMYCIN A07AA01 A01AB08 A A01 A01A A01AB NEOMYCIN B05CA09 A01AB08 A A01 A01A A01AB NEOMYCIN D06AX04 A01AB08 A A01 A01A A01AB NEOMYCIN J01GB05 A01AB08 A A01 A01A A01AB NEOMYCIN R02AB01 A01AB08 A A01 A01A A01AB NEOMYCIN S01AA03 A01AB08 A A01 A01A A01AB NEOMYCIN S02AA07 A01AB08 A A01 A01A A01AB NEOMYCIN S03AA01 A01AB08 A A01 A01A A01AB MICONAZOLE A07AC01 A01AB09 A A01 A01A A01AB MICONAZOLE D01AC02 A01AB09 A A01 A01A A01AB MICONAZOLE G01AF04 A01AB09 A A01 A01A A01AB MICONAZOLE J02AB01 A01AB09 A A01 A01A A01AB MICONAZOLE S02AA13 A01AB09 A A01 A01A A01AB NATAMYCIN A07AA03 A01AB10 A A01
    [Show full text]
  • Supportive Therapies in Ano-Rectal Diseases – Are They Really Useful?
    UDK 616.351/.352-006.04-08 /STRU^NI RAD DOI:10.2298/ACI1003083G Supportive therapies in ano-rectal diseases – Are they really......................................... useful? P. J. Gupta, Fine Morning Hospital and Research Center, D/9, Laxminagar, Nagpur. India. Epidemiological features of proctological disease Ointments containing opiates, xylocain, amethocain, are not well known because available studies have and cinchocain to relieve pain, belladonna to alleviate provided variable conclusions. Risk factors fre- sphincter spasm and silver nitrate to promote healing have quently mentioned include heredity, high socio- all had been in use. These mixtures are introduced either economic level, obesity, smoking, a diet rich in with the finger or through a short rectal bogie to ensure a fats, alcohol, spices and pepper as well low fluid thorough application over the affected part of the anus. rezime intake have all been implicated. Recent reports of topical application of Solcoderm, While treating patients with various ano-rectal pa- Ketanserin gel, eutectic mixtures of 5% Prilocain and 5% thologies, apart from definitive treatment, various ad- Lidocain or combination of Policresulen and Cinchocain ditional or supportive therapies are being advised both have all shown good symptomatic relief in anal pain. 2 by the family physicians and surgeons. These include Topical sucralafte and metronidazole have been found local applications, sitz baths, modification in the diet to reduce pain after hemorrhoidectomy and promoting and life style. But are these supportive therapies really faster wound healing. beneficial or they are just empirical? Some hemorrhoids are associated with high resting anal This paper elaborates the various supportive therapies canal pressures.
    [Show full text]
  • Curettage and Policresulen Tampon As a Modality Treatment in Management of Verucca
    RECONSTRUCTIVE Curettage and Policresulen Tampon as A Modality Treatment in Management of Verucca Huntal Simamora, Puri Ambar Lestari, Kristaninta Bangun, Gentur Sudjatmiko Jakarta, Indonesia. Background: Verruca, also known as warts is a skin disease characterized by epidermal growth. Verruca may occur anywhere especially on palms and soles. It appears as a rough, dark-grey colored surface and has similar features with clavus or callus, which frequently lead to inappropriate management. Patient and Method : We report two cases with verruca, one was on sole and another was on palm area treated with curettage and chemical ablation using policresulen solution. Both cases have histories of recurrences from the previous treatment, which was excision and primary closure. Results : The wound healed within seven days after treatment. There were no recurrences found after 6-month follow up. Summary : Our treatment (curettage and chemical ablation using policresulen) has two advantages: (1) it can avoid excessive tissue removal since this lesion only afect epidermal layer, Pendahuluan: Veruka atau warts adalah kelainan kulit dengan pertumbuhan epidermis yang dapat terjadi di semua kulit tubuh terutama pada telapak tangan dan kaki, dengan tampilan kulit permukaan kasar dan berwarna abu-abu gelap. Ciri-ciri lesi pada veruka yang menyerupai kalus atau klavus sering menyebabkan terjadinya kesalahan penanganan. Pasien dan Metodologi: Kami melaporkan penanganan veruka pada dua kasus. Satu kasus veruka plantaris dua kali residif dan satu kasus veruka palmaris enam kali residif yang sebelumnya ditangani dengan eksisi dan jahit primer. Pada kedua kasus tersebut dilakukan kuretase dan dibakar (ablasi kimia) dengan policresulen. Hasil: Pada evaluasi hari ke-7, didapatkan luka menyembuh dan tidak ditemukan rekurensi pada pengamatan 6 bulan.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2009/0324736A1 Johnson Et Al
    US 20090324736A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0324736A1 Johnson et al. (43) Pub. Date: Dec. 31, 2009 (54) METHODS OF TREATING BOWEL DISEASES (22) Filed: May 7, 2009 BY ADMINISTERING ABOWEL CLEANSER AND AN ANTIBOTC Related U.S. Application Data (60) Provisional application No. 61/051,341, filed on May (75) Inventors: Lorin Johnson, Palo Alto, CA 7, 2008. (US); William Forbes, Raleigh, NC (US); Stephana Patton, San Publication Classification Francisco, CA (US) (51) Int. Cl. Correspondence Address: A633/42 (2006.01) EDWARDS ANGELL PALMER & DODGE LLP A633/14 (2006.01) P.O. BOX SS874 A63L/439 (2006.01) BOSTON, MA 02205 (US) (52) U.S. Cl. .......................... 424/606: 424/679:514/279 (57) ABSTRACT (73) Assignee: Salix Pharmaceuticals, Ltd., Morrisville, NC (US) The present invention relates to formulations and kits for the treatment of bowel disease, to their use in medicinal prepa (21) Appl. No.: 12/437,232 rations and to therapeutic methods thereof. US 2009/032473.6 A1 Dec. 31, 2009 METHODS OF TREATING BOWEL DISEASES 0009. According to one embodiment, the GI cleanser BY ADMINISTERING ABOWEL CLEANSER comprises one or more of a PEG based composition or a AND AN ANTIBOTC Sodium phosphate based composition. 0010. According to one embodiment, the GI cleanser RELATED APPLICATIONS comprises polyethylene glycol (PEG), sodium sulfate, 0001. This application claims the benefit of U.S. Provi Sodium chloride, potassium chloride, and ascorbic acid. sional Application No. 61/051,341, filed May 7, 2008, the 0011. According to one embodiment, the GI cleanser is entire contents of which is expressly incorporated herein by supplied as two pouch A's comprising 100 grams of PEG reference.
    [Show full text]
  • Reseptregisteret 2014–2018 the Norwegian Prescription Database 2014–2018
    LEGEMIDDELSTATISTIKK 2019:2 Reseptregisteret 2014–2018 The Norwegian Prescription Database 2014–2018 Reseptregisteret 2014–2018 The Norwegian Prescription Database 2014–2018 Christian Lie Berg Kristine Olsen Solveig Sakshaug Utgitt av Folkehelseinstituttet / Published by Norwegian Institute of Public Health Område for Helsedata og digitalisering Avdeling for Legemiddelstatistikk Juni 2019 Tittel/Title: Legemiddelstatistikk 2019:2 Reseptregisteret 2014–2018 / The Norwegian Prescription Database 2014–2018 Forfattere/Authors: Christian Berg, redaktør/editor Kristine Olsen Solveig Sakshaug Acknowledgement: Julie D. W. Johansen (English text) Bestilling/Order: Rapporten kan lastes ned som pdf på Folkehelseinstituttets nettsider: www.fhi.no / The report can be downloaded from www.fhi.no Grafisk design omslag: Fete Typer Ombrekking: Houston911 Kontaktinformasjon / Contact information: Folkehelseinstituttet / Norwegian Institute of Public Health Postboks 222 Skøyen N-0213 Oslo Tel: +47 21 07 70 00 ISSN: 1890-9647 ISBN: 978-82-8406-014-9 Sitering/Citation: Berg, C (red), Reseptregisteret 2014–2018 [The Norwegian Prescription Database 2014–2018] Legemiddelstatistikk 2019:2, Oslo, Norge: Folkehelseinstituttet, 2019. Tidligere utgaver / Previous editions: 2008: Reseptregisteret 2004–2007 / The Norwegian Prescription Database 2004–2007 2009: Legemiddelstatistikk 2009:2: Reseptregisteret 2004–2008 / The Norwegian Prescription Database 2004–2008 2010: Legemiddelstatistikk 2010:2: Reseptregisteret 2005–2009. Tema: Vanedannende legemidler / The Norwegian
    [Show full text]
  • The Ministry of Agriculture, Fisheries and Rural Development
    THE MINISTRY OF AGRICULTURE, FISHERIES AND RURAL DEVELOPMENT Pursuant to Article 15, paragraph 1, subparagraph 2 of the Food Act (Official Gazette 46/07) and Article 87, paragraph 6 of the Veterinary Act (Official Gazette 41/07), the Minister of Agriculture, Fisheries and Rural Development hereby issues the ORDINANCE ON MAXIMUM RESIDUE LIMITS OF VETERINARY MEDICINAL PRODUCTS IN FOODSTUFFS OF ANIMAL ORIGIN 1 Article 1 1) This Ordinance lays down the maximum residue limits of veterinary medicinal products (hereinafter: VMP) in foodstuffs of animal origin. (2) This Ordinance shall not apply to active principles of biological origin intended to produce active or passive immunity or to diagnose a state of immunity used in immunological VMPs. (3) This Ordinance shall not prejudice the application of special regulations prohibiting the use in livestock farming of certain substances having a hormonal action nor shall it prejudice the measures taken to prevent the unauthorised use of VMPs. Definitions Article 2 1) For the purposes of this Ordinance, the following definitions shall apply: (a) ‘residues of veterinary medicinal products’ means all pharmacologically active substances, whether active principles, excipients or degradation products, and their metabolites which remain in foodstuffs obtained from animals to which the VMP in question has been administered; b) ‘maximum residue limit’ (hereinafter: MRL) means the maximum concentration of residue resulting from the use of a VMP (expressed in mg/kg or µg/kg on a fresh weight basis) which may be legally permitted or recognised as acceptable in or on a food. MRL is based on the type and amount of residue considered to be without any toxicological hazard for human health as expressed by the acceptable daily intake, or on the basis of a temporary acceptable daily intake that utilises an additional safety factor.
    [Show full text]
  • Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes
    Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2004) -- Supplement 1 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABACAVIR 136470-78-5 ACEXAMIC ACID 57-08-9 ABAFUNGIN 129639-79-8 ACICLOVIR 59277-89-3 ABAMECTIN 65195-55-3 ACIFRAN 72420-38-3 ABANOQUIL 90402-40-7 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABCIXIMAB 143653-53-6 ACITEMATE 101197-99-3 ABECARNIL 111841-85-1 ACITRETIN 55079-83-9 ABIRATERONE 154229-19-3 ACIVICIN 42228-92-2 ABITESARTAN 137882-98-5 ACLANTATE 39633-62-0 ABLUKAST 96566-25-5 ACLARUBICIN 57576-44-0 ABUNIDAZOLE 91017-58-2 ACLATONIUM NAPADISILATE 55077-30-0 ACADESINE 2627-69-2 ACODAZOLE 79152-85-5 ACAMPROSATE 77337-76-9 ACONIAZIDE 13410-86-1 ACAPRAZINE 55485-20-6 ACOXATRINE 748-44-7 ACARBOSE 56180-94-0 ACREOZAST 123548-56-1 ACEBROCHOL 514-50-1 ACRIDOREX 47487-22-9 ACEBURIC ACID 26976-72-7
    [Show full text]