DOCSLIB.ORG

Report Name:Ukraine's Mrls for Veterinary Drugs

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Report Name:Ukraine's Mrls for Veterinary Drugs Voluntary Report – Voluntary - Public Distribution Date: November 05,2020 Report Number: UP2020-0051 Report Name: Ukraine's MRLs for Veterinary Drugs Country: Ukraine Post: Kyiv Report Category: FAIRS Subject Report Prepared By: Oleksandr Tarassevych Approved By: Robin Gray Report Highlights: Ukraine adopted several maximum residue levels (MRLs) for veterinary drugs, coccidiostats and histomonostats in food products of animal origin. Ukraine also adopted a list of drugs residues that are not allowed in food products. THIS REPORT CONTAINS ASSESSMENTS OF COMMODITY AND TRADE ISSUES MADE BY USDA STAFF AND NOT NECESSARILY STATEMENTS OF OFFICIAL U.S. GOVERNMENT POLICY The Office of Agricultural Affairs of USDA/Foreign Agricultural Service in Kyiv, Ukraine prepared this report for U.S. exporters of domestic food and agricultural products. While every possible care was taken in the preparation of this report, information provided may not be completely accurate either because policies have changed since the time this report was written, or because clear and consistent information about these policies was not available. It is highly recommended U.S. exporters verify the full set of import requirements with their foreign customers, who are normally best equipped to research such matters with local authorities, before any goods are shipped. This FAIRS Subject Report accompanies other reports on Maximum, Residue Limits established by Ukraine in 2020. Related reports could be found under the following links: 1.) Ukraine's MRLs for Microbiological Contaminants_Kyiv_Ukraine_04-27-2020 2.) Ukraine's MRLs for Certain Contaminants_Kyiv_Ukraine_03-06-2020 Food Products of animal origin and/or ingredients of animal origin are not permitted in the Ukrainian market if they contain certain veterinary drugs residues in excess of the maximum residue levels established in Tables 1 and 2. Food Products of animal origin and/or ingredients of animal origin are not permitted in the Ukrainian market if they contain certain veterinary drugs residues established in Table 3. Table 1. Veterinary Drug Active Substances Maximum Residue Levels in Food Products of Animal Origin Active Substance Leftover Animals MRLs Target Warnings Therapeutic indicator Tissues Classification Abamectin Abamectin Cows 10 µg/kg Fat Absent Antiparasitic B1a 20 µg/kg Liver substances / substances against endo- and Sheep 20 µg/kg Muscles Not to be administered to animals ectoparasites 50 µg/kg Fat milk of which is intended for 25 µg/kg Liver human consumption 20 µg/kg Kidneys Absinthium extract Not Used All productive Not Not Used Absent Absent animals Required Acetyl cysteine Not Used All productive Not Not Used Absent Absent animals Required Acetylmethionine Not Used All productive Not Not Used Absent Absent animals Required Acetylsalicylic acid Not Used All productive Not Not Used Not to be administered to animals Absent animals, with Required milk or eggs of which are used for exception of human consumption aquaculture Acetylsalicylic acid Not Used All productive Not Not Used Not to be administered to animals Absent DL-lysine animals, with Required milk or eggs of which are used for exception of human consumption aquaculture 2 Adenosine and its 5'- Not Used All productive Not Not Used Absent Absent mono-, 5'-di- and 5' animals Required triphosphates Adonis vernalis Not Used All productive Not Not Used To be used in homeopathic Absent animals Required veterinary medications prepared in accordance with homeopathic pharmacopoeias, in concentrations not exceeding 1/100 Aesculus hippocastanum Not Used All productive Not Not Used To be used in homeopathic Absent animals Required veterinary medications prepared in accordance with homeopathic pharmacopoeias, in concentrations not exceeding 1/10 Agnus castus Not Used All productive Not Not Used To be used in homeopathic Absent animals Required veterinary medications prepared in accordance with homeopathic pharmacopoeias, in concentrations that match matrix and its dilutions Ailanthus altissima Not Used All productive Not Not Used To be used in homeopathic Absent animals Required veterinary medications prepared in accordance with homeopathic pharmacopoeias, in concentrations that match matrix and its dilutions Alanine Not Used All productive Not Not Used Absent Absent animals Required Alarelin Not Used All productive Not Not Used Absent Substances that animals Required impact reproductive system Albendazole Mix of All ruminants 100 µg/kg Muscles Absent Antiparasitic albendazole 100 µg/kg Fat substances / suphoxid, 1000 µg/kg Liver substances against albendazole 500 µg/kg Kidneys endoparasites sulphon, and 100 µg/kg Milk albendazole 2- aminosulphon e, in albendazoleeq uivalent Albendazole oxide Mix of Cows, Sheep 100 µg/kg Muscles Absent Antiparasitic albendazole 100 µg/kg Fat substances / suphoxid, 1000 µg/kg Liver substances against albendazole 500 µg/kg Kidneys endoparasites sulphon, and 100 µg/kg Milk albendazole 2- aminosulphon e, in 3 albendazoleeq uivalent Alfacalcidol Not Used Cows Not Not Used For pregnant cows only Absent Required Alfaprostol Not Used Cows, Swine, Not Not Used Absent Absent Rabbits, Required Equidae Family Allantoin Not Used All productive Not Not Used For local application Absent animals Required Allium cepa Not Used All productive Not Not Used To be used in homeopathic Absent animals Required veterinary medications prepared in accordance with homeopathic pharmacopoeias, in concentrations that match matrix and its dilutions Aloe vera gel and whole Not Used All productive Not Not Used For local application Absent leaf extract of Aloe vera animals Required Aloes, Barbados and Not Used All productive Not Not Used Absent Absent Capae, their standardized animals Required dry extract and preparations thereof Alphacypermethrin Cypermethrin Cows, Sheep 20 µg/kg Muscles Possibility of consumption as Antiparasitic (mix of 200 µg/kg Fat pesticide needs to be considered substances / isomers) 20 µg/kg Liver when MRL for milk is established substances against 20 µg/kg Kidneys ectoparasites 20 µg/kg Milk Altrenogest Altrenogest Swine 4 µg/kg Skin and Fat For zootechnical purposes only Substances that 2 µg/kg Liver impact reproductive system Equidae 4 µg/kg Fat Family 4 µg/kg Liver Aluminium distearate Not Used All productive Not Not Used Absent Absent animals Required Aluminium hydroxide Not Used All productive Not Not Used Absent Absent animals Required Aluminium hydroxide Not Used All productive Not Not Used Absent Absent acetate animals Required Aluminium monostearate Not Used All productive Not Not Used Absent Absent animals Required 4 Aluminium phosphate Not Used All productive Not Not Used Absent Absent animals Required Aluminium salicylate, Salicylic acid Cows, 200 µg/kg Muscles Absent Anti-diarrhea basic Goats, 500 µg/kg Fat substances used for Equidae 1500 µg/kg Liver intestine Family, 1500 µg/kg Kidneys inflammatory Rabbits diseases Cows, goats, 9 µg/kg Milk Equidae Family Not Used All productive Not Not Used For local application animals, with Required exception of cows, goats, horses, aquaculture Aluminium tristearate Not Used All productive Not Not Used Absent Absent animals Required 2-Aminoethanol Not Used All productive Not Not Used Absent Absent animals Required 2-Aminoethanol Not Used All productive Not Not Used Absent Absent glucuronate animals Required 2-Aminoethyl Not Used All productive Not Not Used Absent Absent dihydrogenphosphate animals Required Amitraz A mixture of Cows 200 µg/kg Fat Absent Antiparasitic amitraz and 200 µg/kg Liver substances / all 200 µg/kg Kidneys substances against metabolites 10 µg/kg Milk ectoparasites containing 2,4-DMA fraction Sheep 400 µg/kg Fat expressed as 100 µg/kg Liver amitraz 200 µg/kg Kidneys 10 µg/kg Milk Goats 200 µg/kg Fat 100 µg/kg Liver 200 µg/kg Kidneys 10 µg/kg Milk Swine 400 µg/kg Skin and Fat 200 µg/kg Liver 200 µg/kg Kidneys Bees 200 µg/kg Honey 5 Ammonium chloride Not Used All productive Not Not Used Absent Absent animals Required Ammonium lauryl Not Used All productive Not Not Used Absent Absent sulphate animals Required Ammonium sulfate Not Used All productive Not Not Used Absent Absent animals Required Amoxicillin All productive 50 µg/kg Muscles For aquaculture the MRL in Antimicrobials/ Amoxicillin animals 50 µg/kg Fat muscles is applied to “muscles Antibiotics 50 µg/kg Liver and skin” taken in natural 50 µg/kg Kidneys proportion. 4 µg/kg Milk MRLs in fat, liver and kidneys are not applicable to aquaculture. For pigs and poultry the MRL in fat is applied to skin and fat taken in natural proportion. Not to be administered to animals eggs of which are intended for human consumption Ampicillin Ampicillin All productive 50 µg/kg Muscles For aquaculture the MRL in Antimicrobials/ animals 50 µg/kg Fat muscles is applied to “muscles Antibiotics 50 µg/kg Liver and skin” taken in natural 50 µg/kg Kidneys proportion. 4 µg/kg Milk MRLs in fat, liver and kidneys are not applicable to aquaculture. For pigs and poultry the MRL in fat is applied to skin and fat taken in natural proportion. Not to be administered to animals eggs of which are intended for human consumption Amprolium Not Used Poultry Not Not Used Only for oral administration; Absent Required Angelicae radix Not Used All productive Not Not Used Absent Absent aetheroleum animals Required Anisi aetheroleum Not Used All productive Not Not Used Absent Absent animals Required Anisi stellati fructus, Not Used All productive Not Not Used Absent Absent standardized extracts and animals Required preparations thereof
Load more

Recommended publications
  • Antiseptics and Disinfectants for the Treatment Of
    Verstraelen et al. BMC Infectious Diseases 2012, 12:148 http://www.biomedcentral.com/1471-2334/12/148 RESEARCH ARTICLE Open Access Antiseptics and disinfectants for the treatment of bacterial vaginosis: A systematic review Hans Verstraelen1*, Rita Verhelst2, Kristien Roelens1 and Marleen Temmerman1,2 Abstract Background: The study objective was to assess the available data on efficacy and tolerability of antiseptics and disinfectants in treating bacterial vaginosis (BV). Methods: A systematic search was conducted by consulting PubMed (1966-2010), CINAHL (1982-2010), IPA (1970- 2010), and the Cochrane CENTRAL databases. Clinical trials were searched for by the generic names of all antiseptics and disinfectants listed in the Anatomical Therapeutic Chemical (ATC) Classification System under the code D08A. Clinical trials were considered eligible if the efficacy of antiseptics and disinfectants in the treatment of BV was assessed in comparison to placebo or standard antibiotic treatment with metronidazole or clindamycin and if diagnosis of BV relied on standard criteria such as Amsel’s and Nugent’s criteria. Results: A total of 262 articles were found, of which 15 reports on clinical trials were assessed. Of these, four randomised controlled trials (RCTs) were withheld from analysis. Reasons for exclusion were primarily the lack of standard criteria to diagnose BV or to assess cure, and control treatment not involving placebo or standard antibiotic treatment. Risk of bias for the included studies was assessed with the Cochrane Collaboration’s tool for assessing risk of bias. Three studies showed non-inferiority of chlorhexidine and polyhexamethylene biguanide compared to metronidazole or clindamycin. One RCT found that a single vaginal douche with hydrogen peroxide was slightly, though significantly less effective than a single oral dose of metronidazole.
    [Show full text]
  • Upregulation of Peroxisome Proliferator-Activated Receptor-Α And
    Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer Chih-Yang Wang, Ying-Jui Chao, Yi-Ling Chen, Tzu-Wen Wang, Nam Nhut Phan, Hui-Ping Hsu, Yan-Shen Shan, Ming-Derg Lai 1 Supplementary Table 1. Demographics and clinical outcomes of five patients with ampullary cancer Time of Tumor Time to Age Differentia survival/ Sex Staging size Morphology Recurrence recurrence Condition (years) tion expired (cm) (months) (months) T2N0, 51 F 211 Polypoid Unknown No -- Survived 193 stage Ib T2N0, 2.41.5 58 F Mixed Good Yes 14 Expired 17 stage Ib 0.6 T3N0, 4.53.5 68 M Polypoid Good No -- Survived 162 stage IIA 1.2 T3N0, 66 M 110.8 Ulcerative Good Yes 64 Expired 227 stage IIA T3N0, 60 M 21.81 Mixed Moderate Yes 5.6 Expired 16.7 stage IIA 2 Supplementary Table 2. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of an ampullary cancer microarray using the Database for Annotation, Visualization and Integrated Discovery (DAVID). This table contains only pathways with p values that ranged 0.0001~0.05. KEGG Pathway p value Genes Pentose and 1.50E-04 UGT1A6, CRYL1, UGT1A8, AKR1B1, UGT2B11, UGT2A3, glucuronate UGT2B10, UGT2B7, XYLB interconversions Drug metabolism 1.63E-04 CYP3A4, XDH, UGT1A6, CYP3A5, CES2, CYP3A7, UGT1A8, NAT2, UGT2B11, DPYD, UGT2A3, UGT2B10, UGT2B7 Maturity-onset 2.43E-04 HNF1A, HNF4A, SLC2A2, PKLR, NEUROD1, HNF4G, diabetes of the PDX1, NR5A2, NKX2-2 young Starch and sucrose 6.03E-04 GBA3, UGT1A6, G6PC, UGT1A8, ENPP3, MGAM, SI, metabolism
    [Show full text]
  • B Commission Regulation (Eu)
    02010R0037 — EN — 29.09.2018 — 035.001 — 1 This text is meant purely as a documentation tool and has no legal effect. The Union's institutions do not assume any liability for its contents. The authentic versions of the relevant acts, including their preambles, are those published in the Official Journal of the European Union and available in EUR-Lex. Those official texts are directly accessible through the links embedded in this document ►B COMMISSION REGULATION (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin (Text with EEA relevance) (OJ L 15, 20.1.2010, p. 1) Amended by: Official Journal No page date ►M1 Commission Regulation (EU) No 758/2010 of 24 August 2010 L 223 37 25.8.2010 ►M2 Commission Regulation (EU) No 759/2010 of 24 August 2010 L 223 39 25.8.2010 ►M3 Commission Regulation (EU) No 761/2010 of 25 August 2010 L 224 1 26.8.2010 ►M4 Commission Regulation (EU) No 890/2010 of 8 October 2010 L 266 1 9.10.2010 ►M5 Commission Regulation (EU) No 914/2010 of 12 October 2010 L 269 5 13.10.2010 ►M6 Commission Regulation (EU) No 362/2011 of 13 April 2011 L 100 26 14.4.2011 ►M7 Commission Regulation (EU) No 363/2011 of 13 April 2011 L 100 28 14.4.2011 ►M8 Commission Implementing Regulation (EU) No 84/2012 of 1 L 30 1 2.2.2012 February 2012 ►M9 Commission Implementing Regulation (EU) No 85/2012 of 1 L 30 4 2.2.2012 February 2012 ►M10 Commission Implementing Regulation (EU) No 86/2012 of 1 L 30 6 2.2.2012 February 2012 ►M11 Commission
    [Show full text]
  • Tonsillopharyngitis - Acute (1 of 10)
    Tonsillopharyngitis - Acute (1 of 10) 1 Patient presents w/ sore throat 2 EVALUATION Yes EXPERT Are there signs of REFERRAL complication? No 3 4 EVALUATION Is Group A Beta-hemolytic Yes DIAGNOSIS Streptococcus (GABHS) • Rapid antigen detection test infection suspected? (RADT) • roat culture No TREATMENT EVALUATION No A Supportive management Is GABHS confi rmed? B Pharmacological therapy (Non-GABHS) Yes 5 TREATMENT A EVALUATE RESPONSEMIMS Supportive management TO THERAPY C Pharmacological therapy • Antibiotics Poor/No Good D Surgery, if recurrent or complicated response response REASSESS PATIENT COMPLETE THERAPY & REVIEW THE DIAGNOSIS© Not all products are available or approved for above use in all countries. Specifi c prescribing information may be found in the latest MIMS. B269 © MIMS Pediatrics 2020 Tonsillopharyngitis - Acute (2 of 10) 1 ACUTE TONSILLOPHARYNGITIS • Infl ammation of the tonsils & pharynx • Etiologies include bacterial (group A β-hemolytic streptococcus, Haemophilus infl uenzae, Fusobacterium sp, etc) & viral (infl uenza, adenovirus, coronavirus, rhinovirus, etc) pathogens • Sore throat is the most common presenting symptom in older children TONSILLOPHARYNGITIS 2 EVALUATION FOR COMPLICATIONS • Patients w/ sore throat may have deep neck infections including epiglottitis, peritonsillar or retropharyngeal abscess • Examine for signs of upper airway obstruction Signs & Symptoms of Sore roat w/ Complications • Trismus • Inability to swallow liquids • Increased salivation or drooling • Peritonsillar edema • Deviation of uvula
    [Show full text]
  • Bovine Coccidiosis - a Review
    PEER REVIEWED Bovine Coccidiosis - A Review DL Step, DVM, DACVIM; RN Streeter, DVM, MS, DACVIM; JG Kirkpatrick, DVM, DABVP Department of Veterinary Clinical Sciences, Boren Veterinary Teaching Hospital, Oklahoma State University, Stillwater, OK 74078 Abstract mune en hiver meme dans les cas de confinement. Les :feces peuvent contenir des oocystes meme lorsque les Coccidians are protozoa! parasites that are host animaux ne montrent pas de signes cliniques de sorte specific, transmitted by the fecal-oral route and cause qu'un diagnostic de coccidiose doit se baser sur les signes enteritis. Economically significant species discussed in cliniques et exclure les autres maladies. L'identification this paper that cause disease in cattle belong to the ge­ post-mortem de coccidies aide a supporter le diagnostic. nus Eimeria. Young animals are more susceptible to Les elements de regie qui reduisent le stress et clinical disease than older cattle. Coccidiosis is fre­ previennent la contamination de l'eau et de la nourriture quently observed in stressed, overcrowded and confined sont importants pour prevenir la coccidiose. Les conditions, however, .the disease can occur on pasture. programmes de controle efficaces incluent souvent The disease can occur any time of the year but is more !'utilisation de nourriture et d'eau medicamentes. Les prevalent during winter months, even in confinement agents antimicrobiens couramment utilises aux Etats­ operations. Animals may pass oocysts in their feces with­ Unis pour le controle et la prevention de coccidiose out clinical disease, therefore, a diagnosis of coccidiosis incluent entre autres le monensin, le lasalocide, le is based on clinical signs and ruling out other diseases.
    [Show full text]
  • Download PDF (Inglês)
    Braz. J. vet. Res. anim. Sci., São Paulo, v. 38, n. 3, p. 142-145, 2001. CORRESPONDENCE TO: Lecirelin and Buserelin (Gonadotrophin Pietro Sampaio Baruselli Departamento de Reprodução Animal da Faculdade de Medicina releasing hormone agonists) are equally effective Veterinária e Zootecnia da USP Av. Prof. Dr. Orlando Marques de for fixed time insemination in buffalo Paiva, 87 Cidade Universitária Armando de Salles Oliveira 05508-000 – São Paulo – SP A Lecirelina apresenta eficiência similar à da Buserelina e-mail: [email protected] 1- Departamento de Reprodução (agonistas do hormônio liberador de Gonadotrofinas) Animal da Faculdade de Medicina Veterinária e Zootecnia da USP – SP para inseminação artificial em tempo fixo em bubalinos 2- Médico Veterinário Autônomo Pietro Sampaio BARUSELLI1; Renato AMARAL2; Francisco Bonomi BARUFI1; Renato VALENTIM1; Marcio de Oliveira MARQUES1 SUMMARY Buffalo has peculiar reproductive patterns, which make artificial insemination programs a hard and expensive task. Artificial insemination in fixed time is advantaged because females show low incidence of homosexual behaviour and strong dominance relationships, which leads to a poor accuracy in estrus detection. The aim of this experiment was to compare the efficiency of two different GnRH agonists in the GnRH/PGF2α/GnRH protocol (Buserelin vs Lecirelin). Two hundred and seventy buffaloes with 45 to 60 days postpartum were synchronized and fixed-time inseminated. The animals were kept on pasture in two farms at São Paulo and Mato Grosso do Sul (Brazil). Cows in Group 1 (n = 132) received, intramuscularly, 20 µg of Buserelin at a random day of the estrous cycle and, seven days later, 15 mg of prostaglandin F2α.
    [Show full text]
  • Fully Automated Dried Blood Spot Sample Preparation Enables the Detection of Lower Molecular Mass Peptide and Non-Peptide Doping Agents by Means of LC-HRMS
    Analytical and Bioanalytical Chemistry (2020) 412:3765–3777 https://doi.org/10.1007/s00216-020-02634-4 RESEARCH PAPER Fully automated dried blood spot sample preparation enables the detection of lower molecular mass peptide and non-peptide doping agents by means of LC-HRMS Tobias Lange1 & Andreas Thomas1 & Katja Walpurgis1 & Mario Thevis1,2 Received: 10 December 2019 /Revised: 26 March 2020 /Accepted: 31 March 2020 # The Author(s) 2020 Abstract The added value of dried blood spot (DBS) samples complementing the information obtained from commonly routine doping control matrices is continuously increasing in sports drug testing. In this project, a robotic-assisted non-destructive hematocrit measurement from dried blood spots by near-infrared spectroscopy followed by a fully automated sample preparation including strong cation exchange solid-phase extraction and evaporation enabled the detection of 46 lower molecular mass (< 2 kDa) peptide and non-peptide drugs and drug candidates by means of LC-HRMS. The target analytes included, amongst others, agonists of the gonadotropin-releasing hormone receptor, the ghrelin receptor, the human growth hormone receptor, and the antidiuretic hormone receptor. Furthermore, several glycine derivatives of growth hormone–releasing peptides (GHRPs), argu- ably designed to undermine current anti-doping testing approaches, were implemented to the presented detection method. The initial testing assay was validated according to the World Anti-Doping Agency guidelines with estimated LODs between 0.5 and 20 ng/mL. As a proof of concept, authentic post-administration specimens containing GHRP-2 and GHRP-6 were successfully analyzed. Furthermore, DBS obtained from a sampling device operating with microneedles for blood collection from the upper arm were analyzed and the matrix was cross-validated for selected parameters.
    [Show full text]
  • NINDS Custom Collection II
    ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC
    [Show full text]
  • 20201127-Brochure-Dalmarelin.Pdf
    The new-generation GnRH super-agonist ® LECIRELIN RESEARCH FOR REPRODUCTION Lecirelin GnRH GnRH (Gonadotropin-Releasing A breakthrough Hormone), a decapeptide produced by neurons in the in Pharmaceutical Design basal hypothalamus, is the master hormone controlling and Engineering reproductive physiology. Gly NH2 It stimulates the synthesis Dalmarelin contains Lecirelin, a new-generation Pro and secretion of FSH GnRH (Follicle-Stimulating Hormone) GnRH super-agonist, which elicits a strong LH surge Arg and of LH (Luteinizing and a sustained FSH release from the Leu Hormone) from the anterior anterior pituitary gland. pituitary gland. LH and FSH Gly finally acts on the gonads to Tyr stimulate gametogenesis and Ser steroidogenesis and to regulate the estrous cycle. Trp R His ES EA pGlu R C H NEt Lecirelin D-tert Leu State-of-the-art research and technology have Lecirelin is a nonapeptide modeled after the natural GnRH decapeptide. The design of this GnRH agonist has been directed toward stabilization of the molecule and allowed to synthesize increasing its affinity for the GnRH receptor. a drug which shows Substitution of glycin at position 6 with D-tert-leucin has conferred greater stability against maximal potency, still enzymatic degradation and increased receptor binding affinity. Replacement of glycine by preserving a physiological ethylamide at position 10 has enhanced biological potency and conveyed further resistance to response proteolysis. ® Potent action, high efficacy For any of the clinical or management uses, the key biological response to evaluate efficacy of GnRH products is an adequate LH surge. AUCLH 20 Gonadorelin 100 µg 60 Lecirelin 25 µg 18 50 Lecirelin 50 µg LH (ng/ml) 16 Buserelin 10 µg 40 30 14 ng.h/ml 20 12 10 10 0 8 Gonadorelin Buserelin Lecirelin 25 Lecirelin 50 6 Time course of plasma LH Area under the LH concentrations (ng/mL) concentration curve 4 after administration of after administration gonadorelin, lecirelin and of gonadorelin, lecirelin 2 buserelin.
    [Show full text]
  • Environmental Effects of Chemicals Used Against Salmon Lice
    STRANDBÚNAÐUR 2018 Grand Hótel Reykjavík, 19. – 20. mars 2018 Renée Katrin Bechmann Environmental effects of chemicals used against salmon lice 21 March 2018 In aquaculture, pesticides are used against parasitic salmon lice to protect the health of farmed and wild Atlantic salmon. - How can this use of pesticides as medicine affect our coastal marine environment? Economic consequences Costs billions for the aquaculture industry Salmon lice and the war against lice Environmental concequences Animal welfare for farmed and wild salmon How to get rid of lice Risk for reduced stocks of wild salmon Kill them with chemicals Animal welfare and overfishing of cleaner fish Use cleaner fish and other non-chemical methods Risk for non-target crustaceans, and the rest of Protect the salmon from lice in (semi-)closed cages the coastal ecosystem The perfect anti-salmon lice medicine Low toxicity to: Humans High toxicity to: Salmon lice Salmon = target crustaceans Must eat the chemical or swim in a solution Fast depuration after treatment of the fish The environment including non-target crustaceans Must die! Fast degradation Low bioavailability … and not develop resistance Low toxicity kg used per year (log scale) 100000000 10000000 1000000 100000 10000 1000 100 10 1 1981 salmon lice 1981 usedChemicals against 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 - 2010 2017 2011 2012 2013 2014 2015 2016 2017 peroxide Hydrogen benzoate Emamectin Deltamethrin
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • Chemotherapeutants Against Salmon Lice Lepeophtheirus Salmonis – Screening of Efficacy
    Chemotherapeutants against salmon lice Lepeophtheirus salmonis – screening of efficacy Stian Mørch Aaen Thesis for the degree of Philosophiae Doctor Department of Food Safety and Infection Biology Faculty of Veterinary Medicine and Biosciences Norwegian University of Life Sciences Adamstuen 2016 1 2 TABLE OF CONTENTS Acknowledgments 5 Acronyms/terminology 7 List of papers 8 Summary 9 Sammendrag 9 1 Introduction 11 1.1 Salmon farming in an international perspective; industrial challenges 11 1.2 Salmon lice 12 1.2.1 History and geographic distribution 12 1.2.2 Salmon lice life cycle 14 1.2.3 Pathology caused by salmon lice 16 1.2.4 Salmon lice cultivation in the lab 16 1.3 Approaches to combat sea lice 17 1.3.1 Medicinal interference: antiparasitic chemotherapeutants 17 1.3.2 Resistance in sea lice against chemotherapeutants 19 1.3.3 Non-medicinal intervention: examples 22 1.3.3.1 Physical barriers 23 1.3.3.2 Optical and acoustic control measures 23 1.3.3.3 Functional feeds, vaccine, breeding 24 1.3.3.4 Biological de-lousing: cleaner fish and freshwater 24 1.3.3.5 Physical removal 24 1.3.3.6 Fallowing and geographical zones 25 1.4 Rationale 25 2 Aims 26 3 Materials and methods 26 3.1 Materials 26 3.1.1 Salmon lice 26 3.1.2 Fish – Atlantic salmon 26 3.1.3 Water 27 3.1.3 Medicinal compounds 27 3.1.4 Dissolvents 29 3.2 Methods 29 3.2.1 Hatching assays with egg strings 29 3.2.2 Survival assays with nauplii 29 3.2.3 Bioassays with preadults 30 3.2.4 Statistical analysis 31 4 Summary of papers, I-IV 32 5 Discussion 35 5.1 Novel methods for medicine screening 35 5.2 Industrial innovation in aquaculture and pharmaceutical companies 35 5.3 Administration routes of medicinal compounds to fish 36 5.4 Mixing and bioavailability of medicinal products in seawater 37 5.5 Biochemical targets in L.
    [Show full text]