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Home , Dimethyl fumarate, Gadoversetamide, Picamilon, Policresulen

Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 133,7889 A01 STOMATOLOGICAL PREPARATIONS 0,0705 A01A STOMATOLOGICAL PREPARATIONS 0,0705 A01AB Antiinfectives and for local oral treatment 0,0705 A01AB09 (O) 6912,8g 0,2g 0,0705 A01AB12 Hexetidine (O) 2377400 ml A01AB81 Neomycin+ Benzocaine (C) 21500 pieces A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 2600 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ (gingival) 170530 g A01AD81 Lidocaine+ Cetrimide (O) 21870 g A01AD82 Choline salicylate (O) 894192 pieces A01AD83 Lidocaine+ Chamomille extract (O) 301050g A01AD86 Lidocaine+ Eugenol (gingival) 1020 g A02 DRUGS FOR ACID RELATED DISORDERS 31,4193 A02A ANTACIDS 0,9466 Combinations and complexes of aluminium, calcium and A02AD 0,9466 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 515720pieces 10pieces 0,1052 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 2075316ml 50ml 0,0846 A02AD82 Aluminium aminoacetate+ Magnesium oxide (O) 557900pieces 10pieces 0,1138 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3153744pieces 10pieces 0,6430 A02AF Antacids with antiflatulents Aluminium hydroxide+ Magnesium hydroxide+ Simeticone A02AF80 1013880 ml (O) DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 30,4727 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 3,9822 A02BA02 Ranitidine (O) 582235,35g 0,3g 3,9572 A02BA02 Ranitidine (P) 3675,5g 0,3g 0,0250 A02BC Proton pump inhibitors 26,4905 A02BC01 Omeprazole (O) 183660,54g 0,02g 18,7241 A02BC02 Pantoprazole (O) 88416,16g 0,04g 4,5070 A02BC03 Lansoprazole (O) 23,52g 0,03g 0,0016 A02BC05 Esomeprazole (O) 45352,16g 0,03g 3,0824 A02BC05 Esomeprazole (P) 2581,2g 0,03g 0,1754 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 5,2160 DISORDERS A03A DRUGS FOR FUNCTIONAL BOWEL DISORDERS 4,2426 A03AA Synthetic anticholinergics, esters with tertiary amino group 0,6335 A03AA04 Mebeverine (O) 93204g 0,3g 0,6335 Synthetic anticholinergics, quaternary ammonium A03AB <0,0001 compounds A03AB02 Glycopyrronium (P) 0,006g 3mg <0,0001 A03AD Papaverine and derivatives 3,6091 A03AD01 Papaverine hydrochloride (P) 82g 0,1g 0,0017 A03AD02 Drotaverine (O) 172152,8g 0,1g 3,5102 A03AD02 Drotaverine (P) 4771g 0,1g 0,0973 A03AX Other drugs for functional bowel disorders A03AX81 Simeticone (O) 377382,8229 g A03B BELLADONNA AND DERIVATIVES, PLAIN 0,1106 A03BA Belladonna alkaloids, tertiary amines 0,0884 A03BA01 Atropine (O, P) 37,55g 0,0015g 0,0510 A03BA01 Atropine (P) 27,45g 0,0015g 0,0373 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0223 compounds

1/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03BB01 Butylscopolamine (O) 80,8g 0,06g 0,0027 A03BB01 Butylscopolamine (P) 565,2g 0,06g 0,0192 A03BB01 Butylscopolamine (R) 9,6g 0,06g 0,0003 A03F PROPULSIVES 0,8628 A03FA Propulsives 0,8628 A03FA01 Metoclopramide (O) 10132g 0,03g 0,6886 A03FA01 Metoclopramide (P) 2234,5g 0,03g 0,1519 A03FA01 Metoclopramide (R) 2,75g 0,03g 0,0002 A03FA02 Cisapride (O) 2,3g 0,03g 0,0002 A03FA03 Domperidone (O) 322,8g 0,03g 0,0219 A03FA80 Itopride (O) 32 g A04 ANTIEMETICS AND ANTINAUSEANTS 0,1141 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1141 A04AA Serotonin (5-HT3) antagonists 0,1014 A04AA01 Ondansetron (O) 91,12g 0,016g 0,0116 A04AA01 Ondansetron (P) 200,88g 0,016g 0,0256 A04AA02 Granisetron (O) 39,21g 0,002g 0,0400 A04AA02 Granisetron (P) 35,65g 0,003g 0,0242 A04AD Other antiemetics 0,0126 A04AD12 (O) 406,995g 0,095g 0,0087 A04AD81 Fosaprepitant (P) 181,85g 0,095g 0,0039 A05 BILE AND LIVER THERAPY 2,0093 A05A BILE THERAPY 0,4055 A05AA Bile acid preparations 0,4055 A05AA02 Ursodeoxycholic acid (O) 149162,5g 0,75g 0,4055 A05B LIVER THERAPY, LIPOTROPICS 1,6038 A05BA Liver therapy 1,6038 A05BA03 Silymarin (O) 3792160 pieces A05BA80 Essentsiaalsed fosfolipiidid (O) 2359680pieces 3pieces 1,6038 A05BA80 Essentsiaalsed fosfolipiidid (P) 4745 pieces A06 LAXATIVES 12,4293 A06A LAXATIVES 12,4293 A06AB Contact laxatives 6,3228 A06AB02 Bisacodyl (O) 15889,6g 0,01g 3,2399 A06AB02 Bisacodyl (R) 1348,7g 0,01g 0,2750 A06AB05 Castor oil (O) 94440g 20g 0,0096 A06AB06 Senna glycosides (O) 22840pieces 1pieces 0,0466 A06AB08 Sodium picosulfate (O) 6747,9081g 0,005g 2,7518 A06AD Osmotically acting laxatives 5,5483 A06AD11 Lactulose (O) 17875678,5g 6,7g 5,4400 A06AD15 Macrogol (O) 530800g 10g 0,1082 Sodium sulphate, anhydrous+ Potassium chloride+ Sodium A06AD81 57371 pieces chloride+ Macrogol+ Sodium hydrogen carbonate (O) Macrogol+ Sodium chloride+ Sodium hydrogen carbonate+ A06AD84 6808 pieces Potassium chloride (O) A06AG Enemas 0,5582 A06AG11 Laurilsulfate, incl. combinations+ Sorbitol+ Sodium citrate (R) 273764pieces 1pieces 0,5582 A06AX Other laxatives A06AX01 Glycerol (R) 400 pieces ANTIDIARRHEALS, INTESTINAL A07 3,2584 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES <0,0001 A07AA Antibiotics <0,0001 A07AA02 Nystatin (O) 20000000U 1500000U <0,0001 A07B INTESTINAL ADSORBENTS 0,4148 A07BC Other intestinal adsorbents 0,4148

2/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A07BC05 Diosmectidum (O) 1830810g 9g 0,4148 A07D ANTIPROPULSIVES 0,8054 A07DA Antipropulsives 0,8054 A07DA03 Loperamide (O) 3950,112g 0,01g 0,8054 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 1,6605 A07EA Corticosteroids acting locally A07EA06 Budesonide (R) 1,6086 g A07EC Aminosalicylic acid and similar agents 1,6605 A07EC01 Sulfasalazine (O) 905800g 2g 0,9235 A07EC02 Mesalazine (O) 497675g 1,5g 0,6765 A07EC02 Mesalazine (R) 44531g 1,5g 0,0605 A07F ANTIDIARRHEAL MICROORGANISMS 0,3777 A07FA Antidiarrheal microorganisms 0,3777 A07FA02 Saccharomyces boulardii (O) 185245g 1g 0,3777 A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0403

A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0403 A08AB Peripherally acting antiobesity products 0,0403 A08AB01 Orlistat (O) 7121,52g 0,36g 0,0403 A09 DIGESTIVES, INCL. ENZYMES 1,3028 A09A DIGESTIVES, INCL. ENZYMES 1,3028 A09AA Enzyme preparations 1,3021 A09AA02 Lipase+ Amylase+ Protease (O) 2554430pieces 4pieces 1,3021 A09AC Enzyme and acid preparations, combinations 0,0007 A09AC80 Pepsin+ Betaine (O) 1050pieces 3pieces 0,0007 A10 DRUGS USED IN DIABETES 52,5146 A10A INSULINS AND ANALOGUES 15,1049 A10AB Insulins and analogues for injection, fast-acting 5,6682 A10AB01 Insulin (human) (P) 1165500U 40U 0,0594 A10AB04 Insulin lispro (P) 24730500U 40U 1,2606 A10AB05 Insulin aspart (P) 73143000U 40U 3,7284 A10AB06 Insulin glulisine (P) 12157500U 40U 0,6197 A10AC Insulins and analogues for injection, intermediate-acting 0,2315 A10AC01 Insulin (human) (P) 4540500U 40U 0,2315 Insulins and analogues for injection, intermediate-acting A10AD 2,0389 combined with fast-acting A10AD04 Insulin lispro (P) 14148000U 40U 0,7212 A10AD05 Insulin aspart (P) 25851000U 40U 1,3177 A10AE Insulins and analogues for injection, long-acting 7,1663 A10AE04 Insulin glargine (P) 74304000U 40U 3,7876 A10AE05 Insulin detemir (P) 66282000U 40U 3,3787 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 37,4097 A10BA 17,5677 A10BA02 Metformin (O) 17231769g 2g 17,5677 A10BB Sulfonamides, urea derivatives 16,9007 A10BB07 Glipizide (O) 2497,5g 0,01g 0,5092 A10BB09 Gliclazide (O) 274423,2g 0,06g 9,3257 A10BB12 Glimepiride (O) 6930,6g 0,002g 7,0657 A10BD Combinations of oral blood glucose lowering drugs 1,0184 A10BD07 Metformin+ Sitagliptin (O) 998928pieces 2pieces 1,0184 A10BG Thiazolidinediones 0,2398 A10BG03 Pioglitazone (O) 3528,42g 0,03g 0,2398 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 1,4811 A10BH01 Sitagliptin (O) 72641,1g 0,1g 1,4811 A10BH05 Linagliptin (O) 135,75 g

3/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A10BX Other blood glucose lowering drugs, excl. insulins 0,2020 A10BX04 Exenatide (P) 0,1929g 0,015mg 0,0262 A10BX07 Liraglutide (P) 103,464g 1,2mg 0,1758 A11 12,7816 A11A MULTIVITAMINS, COMBINATIONS 1,2768 A11AA Multivitamins with minerals 1,2768 A11AA03 Multivitamins+ elements (O) 626190pieces 1pieces 1,2768 A11B MULTIVITAMINS, PLAIN 0,0513 A11BA Multivitamins, plain 0,0513 A11BA80 Multivitamins (O) 251725ml 10ml 0,0513 A11C A AND D, INCL. COMBINATIONS OF THE TWO 1,3628 A11CC Vitamin D and analogues 1,3628 A11CC01 Ergocalciferol (O) 238380800U 400U 1,2151 A11CC04 Calcitriol (O) 0,0724g 0,001mg 0,1477 VITAMIN B1, PLAIN AND IN COMBINATION WITH A11D 1,7829 VITAMIN B6 AND B12 A11DA Vitamin B1, plain 0,1849 A11DA01 Thiamine (P) 4534,65g 0,05g 0,1849 A11DA03 Benfotiamine (O) 99675 g Vitamin B1 in combination with vitamin B6 and/or vitamin A11DB 1,5980 B12 A11DB81 Benfotiamine+ Pyridoxine (O) 132570pieces 3pieces 0,0901 A11DB84 Thiamine+ Pyridoxine+ Cyanocobalamin (O) 605430pieces 1pieces 1,2345 A11DB85 Thiamine+ Pyridoxine+ Cyanocobalamin+ Lidocaine (P) 134115pieces 1pieces 0,2735 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,8521 A11EA Vitamin B-complex, plain 0,8521 Thiamine+ + Riboflavin+ Calcium A11EA80 417900pieces 1pieces 0,8521 pantothenate+ Pyridoxine (O) A11G ASCORBIC ACID (), INCL. COMBINATIONS 3,6797 A11GA Ascorbic acid (vitamin C), plain 3,6797 A11GA01 Ascorbic acid (O) 344160g 0,2g 3,5087 A11GA01 Ascorbic acid (P) 16770g 0,2g 0,1710 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0840 A11HA Other plain vitamin preparations 0,0840 A11HA02 Pyridoxine (O) 220g 0,16g 0,0028 A11HA02 Pyridoxine (P) 2468g 0,16g 0,0315 A11HA03 Tocopherol (O) 4870,44g 0,2g 0,0497 A11HA08 Tocofersolan (O) 6g 0,2g 0,0001 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 3,6920 A11JA Combinations of vitamins A11JA80 Combinations of vitamins (O) 1040 ml A11JB Vitamins with minerals 3,6920 A11JB81 Pyridoxine+ Magnesium (O) 6283300pieces 4pieces 3,2029 Thiamine+ Riboflavin+ Pyridoxine+ Cyanocobalamin+ A11JB82 Ascorbic acid+ Biotin+ Nicotinamide+ Calcium pantothenate+ 239870pieces 1pieces 0,4891 Calcium+ Magnesium (O) A12 MINERAL SUPPLEMENTS 12,1550 A12A CALCIUM 8,4512 A12AA Calcium 0,6177 A12AA03 Calcium gluconate (P) 16550g 3g 0,0112 A12AA04 Calcium carbonate (O) 835500g 3g 0,5679 A12AA12 Calcium acetate (O) 37827g 2g 0,0386 A12AX Calcium, combinations with vitamin D and/or other drugs 7,8335 A12AX80 Calcium+ Colecalciferol (O) 333120pieces 1pieces 0,6792 A12AX80 Calcium+ Colecalciferol (O) 7017530pieces 2pieces 7,1543

4/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A12B POTASSIUM 0,0956 A12BA Potassium 0,0956 A12BA01 Potassium chloride (O) 140640g 3g 0,0956 A12BA80 Potassium chloride+ Potassium hydrogen carbonate (O) 5000pieces A12C OTHER MINERAL SUPPLEMENTS 3,6082 A12CC Magnesium 0,2463 A12CC04 Magnesium citrate (O) 241633,2g 2g 0,2463 A12CX Other mineral products 3,3619 A12CX80 Magnesium aspartate+ Potassium aspartate (O) 4820150pieces 3pieces 3,2761 A12CX80 Magnesium aspartate+ Potassium aspartate (P) 42080pieces 1pieces 0,0858 A12CX83 Phosphate (O) 5800 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0251 A14A ANABOLIC STEROIDS 0,0047 A14AB Estren derivatives 0,0047 A14AB01 Nandrolone (P) 4,65g 0,002g 0,0047 A14B OTHER ANABOLIC AGENTS 0,0204 A14BX Other anabolic agents 0,0204 A14BX80 Riboxine (O) 850 g A14BX80 Riboxine (P) 100g 0,01g 0,0204 OTHER ALIMENTARY TRACT AND METABOLISM A16 0,4526 PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM A16A 0,4526 PRODUCTS A16AA Amino acids and derivatives 0,0021 A16AA01 Levocarnitine (O) 2090g 2g 0,0021 A16AB Enzymes 0,0045 A16AB02 Imiglucerase (P) 115600U 300U 0,0008 A16AB03 Agalsidase alfa (P) 0,791g 0,001g 0,0016 A16AB04 Agalsidase beta (P) 5,235g 0,005g 0,0021 A16AX Various alimentary tract and metabolism products 0,4459 A16AX01 Thioctic acid (O) 42930g 0,2g 0,4377 A16AX01 Thioctic acid (P) 252g 0,2g 0,0026 A16AX03 Sodium phenylbutyrate (O) 1375g 20g 0,0001 A16AX05 acetate dihydrate (O) 406,25g 0,15g 0,0055 A16AX07 Sapropterin (O) 48 g B BLOOD AND BLOOD FORMING ORGANS 90,4456 B01 ANTITHROMBOTIC AGENTS 78,8234 B01A ANTITHROMBOTIC AGENTS 78,8234 B01AA Vitamin K antagonists 7,1475 B01AA03 Warfarin (O) 26290,7g 0,0075g 7,1475 B01AB Heparin group 2,0346 B01AB01 Heparin sodium (P) 438925000U 10000U 0,0895 B01AB02 Antithrombin III (P) 1000U 2100U <0,0001 B01AB04 Dalteparin sodium (P) 81750000U 2500U 0,0667 B01AB05 Enoxaparin sodium (P) 1552660000U 2000U 1,5829 B01AB06 Nadroparin calcium (P) 91817500U 2850U 0,0657 B01AB12 Bemiparin sodium (P) 281745000U 2500U 0,2298 B01AC Platelet aggregation inhibitors, excl. heparin 69,1588 B01AC04 Clopidogrel (O) 145237,95g 0,075g 3,9485 B01AC06 Acetylsalicylic acid (O) 6571228pieces 1pieces 13,3986 B01AC07 Dipyridamole (O) 35g 0,4g 0,0002 B01AC09 Epoprostenol (P) 0,002 g B01AC11 Iloprost (I) 0,0571g 0,15mg 0,0008 B01AC11 Iloprost (P) 0,0045g 50mcg 0,0002 B01AC16 Eptifibatide (P) 42,58g 0,2g 0,0004 B01AC17 Tirofiban (P) 3,3375g 10mg 0,0007 B01AC24 Ticagrelor (O) 22508,64g 0,18g 0,2550

5/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B01AC80 Acetylsalicylic acid + Magnesium oxide (O) 25284340pieces 1pieces 51,5544 B01AC84 Acetylsalicylic acid + Esomeprazole (O) 30 pieces 1pieces 0,0001 B01AD Enzymes 0,0014 B01AD01 Streptokinase (P) 31500000U 1500000U <0,0001 B01AD02 Alteplase (P) 53,3g 0,1g 0,0011 B01AD11 Tenecteplase (P) 5,75g 0,04g 0,0003 B01AE Direct thrombin inhibitors 0,2707 B01AE07 Dabigatran etexilate (O) 29209,3g 0,22g 0,2707 B01AX Other antithrombotic agents 0,2103 B01AX05 Fondaparinux sodium (P) 36,775g 0,0025g 0,0300 B01AX06 Rivaroxaban (O) 884,38g 0,01g 0,1803 B02 0,1748 B02A ANTIFIBRINOLYTICS 0,0915 B02AA Amino acids 0,0915 B02AA01 Aminocaproic acid (P) 39955g 16g 0,0051 B02AA02 Tranexamic acid (O) 69470g 2g 0,0708 B02AA02 Tranexamic acid (P) 15255g 2g 0,0156 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0834 B02BA Vitamin K 0,0313 B02BA01 Phytomenadione (P) 34,49g 0,02g 0,0035 B02BA02 Menadione sodium bisulfite (P) 27,3g 0,002g 0,0278 B02BB Fibrinogen <0,0001 B02BB01 Fibrinogen (P) 4g 5g <0,0001 B02BC Local hemostatics B02BC10 Fibrinogen (NA) 11 pieces B02BC81 Fibrinogen human+ Thrombin (epil) 50 pieces B02BC81 Fibrinogen human+ Thrombin (NA) 168 pieces B02BD Blood coagulation factors 0,0234 B02BD01 Human prothrombin complex (P) 46000U 350U 0,0003 B02BD02 Human coagulation factor VIII (P) 5063500U 500 U 0,0206 B02BD03 Factor VIII inhibitor bypassing activity (P) 391000U 10000U 0,0001 B02BD04 Human coagulation factor IX (P) 366800U 350U 0,0021 B02BD05 Human coagulation factor VII (P) 36000U 6000U <0,0001 Von Willebrand factor, human+ Human coagulation factor B02BD06 898850U 7200U 0,0003 VIII (P) B02BD08 Eptacog alfa (activated) (P) 5500000U 2500000U <0,0001 B02BX Other systemic hemostatics 0,0286 B02BX01 Etamsylate (O) 60pieces 1pieces 0,0001 B02BX01 Etamsylate (P) 11900pieces 1pieces 0,0243 B02BX04 Romiplostim (P) 0,053g 30mcg 0,0036 B02BX05 Eltrombopag (O) 15,4g 50mg 0,0006 B03 ANTIANEMIC PREPARATIONS 11,4473 B03A IRON PREPARATIONS 2,4385 B03AA Iron bivalent, oral preparations 2,2265 B03AA07 Ferrous sulphate (O) 218391g 0,2g 2,2265 B03AB Iron trivalent, oral preparations 0,0008 B03AB05 Dextriferron (O) 37,5g 0,09g 0,0008 B03AB80 Iron (III) hydroxide polymaltose complex (O) 49387 g B03AC Iron trivalent, parenteral preparations 0,0352 B03AC02 Iron (III) hydroxide sucrose complex (P) 628,5g 0,1g 0,0128 B03AC06 Iron (III)-hydroxide dextran complex (P) 1096,5g 0,1g 0,0224 B03AC80 Iron (III) isomaltoside 1000 complex (P) 1g 0,1g <0,0001 B03AD Iron in combination with folic acid 0,1759 B03AD02 Ferrous fumarate+ Folic acid (O) 86290pieces 1pieces 0,1759 B03AE Iron in other combinations Ferrous gluconate+ Copper gluconate+ Manganese B03AE81 1073200 ml gluconate (O) B03B VITAMIN B12 AND FOLIC ACID 8,5074

6/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B03BA Vitamin B12 (cyanocobalamin and analogues) 4,8142 B03BA01 Cyanocobalamin (P) 47,165g 0,02mg 4,8084 B03BA03 Hydroxocobalamin (P) 0,057g 0,02mg 0,0058 B03BB Folic acid and derivatives 3,6931 B03BB01 Folic acid (O) 724,5g 0,4mg 3,6931 B03X OTHER ANTIANEMIC PREPARATIONS 0,5015 B03XA Other antianemic preparations 0,5015 B03XA02 Darbepoetin alfa (P) 0,6906g 0,0045mg 0,3129 B03XA03 Methoxy -epoetin beta (P) 0,1861g 4mcg 0,0948 B03XA80 Epoetin beta (P) 45960000U 1000U 0,0937 B03XA83 Epoetin theta (P) 12000U 1000U <0,0001 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma protein fractions B05AA01 Albumin (P) 244605 g B05AA05 Dextran (P) 15000 ml B05AA06 Gelatin agents (P) 22625000 ml B05AA80 Hydroxyethyl starch+ Sodium chloride (P) 3042000 ml B05AA81 Dextran+ Sodium chloride (P) 329500 ml Hydroxyethyl starch+ Sodium acetate trihydrate+ Sodium B05AA82 2240000 ml chloride+ Potassium chloride+ Magnesium chloride (P) Hydroxyethyl starch+ Sodium chloride+ Potassium chloride+ B05AA84 Calcium chloride dihydrate+ Magnesium chloride+ Sodium 930000 ml acetate trihydrate+ Malic acid (P) B05AA86 human plasma proteins (P) 22000 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids (P) 3452200 ml B05BA02 Fat emulsions (P) 802000 ml B05BA03 Carbohydrates (P) 92514350 ml B05BA10 Combinations (P) 14363466 ml B05BA80 Amino acids and electrolytes (P) 1228500 ml B05BA81 Amino acids+ Fat emulsions+ Glucose (P) 287500 ml B05BB Solutions affecting the electrolyte balance B05BB01 Electrolytes (P) 128214500 ml B05BC Solutions producing osmotic diuresis B05BC01 Mannitol (P) 1267000 ml B05C IRRIGATING SOLUTIONS B05CB Salt solutions B05CB01 Sodium chloride (NA) 28044000 ml B05CX Other irrigating solutions B05CX10 Combinations (NA) 194000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions (P) 13972000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions (P) 152594000 ml B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+ Potassium chloride+ Calcium chloride B05ZB80 dihydrate+ Magnesium chloride+ Glucose+ Sodium 26040000 ml hydrogen carbonate (P) Calcium chloride dihydrate+ Magnesium chloride hexahydrate+ Sodium chloride+ Sodium hydrogen B05ZB82 730000 ml carbonate+ Potassium chloride+ Disodium phosphate dihydrate (P) B05X I.V. SOLUTION ADDITIVES

7/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B05XA Electrolyte solutions B05XA01 Potassium chloride (P) 4194000 ml B05XA02 Sodium hydrogen carbonate (P) 1460000 ml B05XA03 Sodium chloride (P) 528432450 ml B05XA05 Magnesium sulphate (P) 506500 ml B05XA07 Calcium chloride (P) 150300 ml B05XA14 Sodium glycerophosphate, hydrated (P) 62600ml B05XA80 Electrolytes (P) 53300 ml B05XB Amino acids B05XB01 Arginine (P) 3800 ml B05XB02 Alanyl (P) 37000 ml B05XC Vitamins B05XC80 Vitamins (P) 86400 ml B06 OTHER HEMATOLOGICAL AGENTS <0,0001 B06A OTHER HEMATOLOGICAL AGENTS <0,0001 B06AB Other hem products B06AB80 hemoderivate of calf blood, deproteinized (O) 100pieces B06AB80 hemoderivate of calf blood, deproteinized (P) 100pieces B06AB81 Hemin (P) 320 ml B06AC Drugs usedin hereditary angioedema <0,0001 B06AC01 C1-inhibitor (P) 1000U 1400U <0,0001 B06AC02 Icatibant (P) 0,15g 0,03g <0,0001 B06AC04 Conestat alfa (P) 12600U 3500U <0,0001 C CARDIOVASCULAR SYSTEM 394,9331 C01 CARDIAC THERAPY 34,5836 C01A CARDIAC GLYCOSIDES 5,1855 C01AA Digitalis glycosides 5,1855 C01AA05 Digoxin (O) 627,0838g 0,25mg 5,1145 C01AA05 Digoxin (P) 8,455g 0,25mg 0,0690 C01AA06 Lanatoside C (O) 1,005g 0,001g 0,0020 C01B ANTIARRHYTHMICS, CLASS I AND III 5,9309 C01BA Antiarrhythmics, class Ia 0,0004 C01BA01 Quinidine (O) 260g 1,2g 0,0004 C01BB Antiarrhythmics, class Ib 0,3182 C01BB80 Aethacizin (O) 31212,5g 0,2g 0,3182 C01BC Antiarrhythmics, class Ic 2,8035 C01BC03 Propafenone (O) 407430g 0,3g 2,7691 C01BC03 Propafenone (P) 849,45g 0,3g 0,0058 C01BC04 Flecainide (O) 2780g 0,2g 0,0283 C01BC04 Flecainide (P) 22,5g 0,2g 0,0002 C01BD Antiarrhythmics, class III 2,8088 C01BD01 Amiodarone (O) 266742g 0,2g 2,7194 C01BD01 Amiodarone (P) 6288,9g 0,2g 0,0641 C01BD07 Dronedarone (O) 9912g 0,8g 0,0253 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,8223 C01CA Adrenergic and dopaminergic agents 0,8220 C01CA02 Isoprenaline (P) 0,5176g 0,09g <0,0001 C01CA03 Norepinephrine (P) 332,1047g 0,006g 0,1129 C01CA04 Dopamine (P) 3873g 0,5g 0,0158 C01CA06 Phenylephrine (P) 255,7g 0,004g 0,1303 C01CA07 Dobutamine (P) 1253,75g 0,5g 0,0051 C01CA24 Epinephrine (P) 129,8975g 0,5mg 0,5297 C01CA26 Ephedrine (P) 690g 0,05g 0,0281 C01CE Phosphodiesterase inhibitors 0,0002 C01CE02 Milrinone (P) 5,1g 0,05g 0,0002 C01CX Other cardiac stimulants 0,0001 C01CX08 Levosimendan (P) 0,4875g 11mg 0,0001

8/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C01CX80 Ammonia (I) 945120 ml C01D VASODILATORS USED IN CARDIAC DISEASES 11,2399 C01DA Organic nitrates 11,2296 C01DA02 Glyceryl trinitrate (O) 12,675g 0,005g 0,0052 C01DA02 Glyceryl trinitrate (P) 290,9 g C01DA02 Glyceryl trinitrate (SL) 737,696g 0,0025g 0,6017 C01DA05 Pentaerithrityl tetranitrate (O) 12g 0,12g 0,0002 C01DA08 Isosorbide dinitrate (O) 18471,5g 0,06g 0,6277 C01DA08 Isosorbide dinitrate (SL) 412,875g 0,02g 0,0421 C01DA14 Isosorbide mononitrate (O) 195249g 0,04g 9,9527 C01DX Other vasodilatators used in cardiac diseases 0,0103 C01DX80 Meldonium (O) 3780g 0,75g 0,0103 C01E OTHER CARDIAC PREPARATIONS 11,4051 C01EA Prostaglandins 0,0004 C01EA01 Alprostadil (P) 0,1092g 0,5mg 0,0004 C01EB Other cardiac preparations 11,4046 C01EB10 Adenosine (P) 54,432g 0,015g 0,0074 C01EB15 Trimetazidine (O) 222259,8g 0,04g 11,3296 C01EB16 Ibuprofen (P) 1g 0,03g 0,0001 C01EB17 Ivabradine (O) 263,62g 0,01g 0,0538 C01EB18 Ranolazine (O) 10147,5g 1,5g 0,0138 C02 ANTIHYPERTENSIVES 3,7706 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,1579 C02AC Imidazoline receptor agonists 2,1579 C02AC01 Clonidine (O) 9,2475g 0,45mg 0,0419 C02AC01 Clonidine (P) 6,374g 0,45mg 0,0289 C02AC05 Moxonidine (O) 307,076g 0,3mg 2,0871 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,5989 C02CA Alpha-adrenoreceptor antagonists 1,5989 C02CA04 Doxazosin (O) 3136,6g 0,004g 1,5989 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0034 C02DD Nitroferricyanide derivatives 0,0034 C02DD01 Sodium nitroprusside (P) 82,29g 0,05g 0,0034 C02K OTHER ANTIHYPERTENSIVES 0,0105 C02KX Other antihypertensives 0,0105 C02KX01 Bosentan (O) 1172,5g 0,25g 0,0096 C02KX02 Ambrisentan (O) 3,45g 7,5mg 0,0009 ANTIHYPERTENSIVES AND DIURETICS IN C02L COMBINATION C02LA Rauwolfia alkaloids and diuretics in combination C02LA80 Reserpine+ Dihydralazine+ Hydrochlorothiazide (O) 13980pieces C03 DIURETICS 22,5324 C03A LOW-CEILING DIURETICS, THIAZIDES 4,1695 C03AA Thiazides, plain 4,1695 C03AA03 Hydrochlorothiazide (O) 51122,5g 0,025g 4,1695 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,2547 C03BA Sulfonamides, plain 2,2547 C03BA11 Indapamide (O) 2764,515g 2,5mg 2,2547 C03C HIGH-CEILING DIURETICS 13,0714 C03CA Sulfonamides, plain 13,0714 C03CA01 (O) 96669,6g 0,04g 4,9277 C03CA01 Furosemide (P) 4751,6g 0,04g 0,2422 C03CA04 Torasemide (O) 57610,5g 0,015g 7,8311 C03CA04 Torasemide (P) 517,7g 0,015g 0,0704 C03D POTASSIUM-SPARING AGENTS 3,0161

9/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C03DA Aldosterone antagonists 3,0161 C03DA01 Spironolactone (O) 110943g 0,075g 3,0161 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0206 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0206 C03EA80 Hydrochlorothiazide+ Triamterene (O) 250pieces 1pieces 0,0005 C03EA81 Hydrochlorothiazide+ (O) 9870pieces 1pieces 0,0201 C04 PERIPHERAL VASODILATORS 2,7182 C04A PERIPHERAL VASODILATORS 2,7182 C04AB Imidazoline derivatives <0,0001 C04AB01 Phentolamine (P) 0,1g 10mg <0,0001 C04AC Nicotinic acid and derivatives 0,0003 C04AC01 Nicotinic acid (P) 34g 0,2g 0,0003 C04AD Purine derivatives 2,4457 C04AD02 Xantinol nicotinate (O) 1228,5g 0,9g 0,0028 C04AD03 Pentoxifylline (O) 1192496g 1g 2,4315 C04AD03 Pentoxifylline (P) 1677,5g 0,3g 0,0114 C04AX Other peripheral vasodilators 0,2722 C04AX21 Naftidrofuryl (O) 80095g 0,6g 0,2722 C05 VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND C05A ANAL FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA83 Hydrocortisone+ Esculine+ Framycetin+ (R) 69300pieces C05AA84 Fluocortolone+ Lidocaine (R) 97170 g C05AA84 Fluocortolone+ Lidocaine (R) 261940 pieces Other agents for treatment of hemorrhoids and anal fissures C05AX for topical use C05AX81 Xeroformium+ Zinc sulphate+ Extract of Belladonna (R) 29750pieces C05AX83 Yeast cell extract+ Shark liver oil (R) 138060 pieces C05AX85 Hippopheae oleum (R) 760 pieces C05B ANTIVARICOSE THERAPY C05BA Heparins or heparinoids for topical use C05BA01 Organo-heparinoid (C) 287040 g C05BA03 Heparin sodium (C) 6949290 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400 (P) 60,7 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside (C) 773680 g C05CA01 Rutoside (O) 527070 pieces C05CA04 Troxerutin (C) 1906360 g C05CA04 Troxerutin (O) 185430 g C05CA53 Diosmin+ Hesperidine (O) 5010 pieces C05CX Other capillary stabilizing agents C05CX80 Vigne rouge extract (O) 6 g C05CX81 Aescin (O) 214560 pieces C07 BETA BLOCKING AGENTS 40,3796 C07A BETA BLOCKING AGENTS 40,3785 C07AA Beta blocking agents, non-selective 2,2774 C07AA02 Oxprenolol (O) 14,08g 0,16g 0,0002 C07AA05 (O) 34162g 0,16g 0,4353 C07AA07 Sotalol (O) 144528,8g 0,16g 1,8418 C07AB Beta blocking agents, selective 37,3321 C07AB02 Metoprolol (O) 1641319,95g 0,15g 22,3108 C07AB02 Metoprolol (P) 69,35g 0,15g 0,0009

10/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C07AB03 Atenolol (O) 45304,5g 0,075g 1,2317 C07AB07 Bisoprolol (O) 2481,6g 0,01g 0,5060 C07AB09 Esmolol (P) 0,5g 2,5g <0,0001 C07AB12 Nebivolol (O) 32571,67g 0,005g 13,2826 C07AG Alpha and beta blocking agents 0,7690 C07AG01 Labetalol (O) 16003g 0,6g 0,0544 C07AG01 Labetalol (P) 777,5g 0,6g 0,0026 C07AG02 Carvedilol (O) 13095g 0,0375g 0,7120 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0011 C07BB Beta blocking agents, selective, and thiazides 0,0011 C07BB07 Bisoprolol+ Hydrochlorothiazide (O) 540pieces 1pieces 0,0011 C08 CALCIUM CHANNEL BLOCKERS 68,1303 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08C 65,6019 MAINLY VASCULAR EFFECTS C08CA Dihydropyridine derivatives 65,6019 C08CA01 Amlodipine (O) 90862,8g 0,005g 37,0536 C08CA02 Felodipine (O) 16241,85g 0,005g 6,6234 C08CA05 Nifedipine (O) 38788,6g 0,03g 2,6363 C08CA06 Nimodipine (O) 576g 0,3g 0,0039 C08CA06 Nimodipine (P) 1,55g 0,05g 0,0001 C08CA08 Nitrendipine (O) 65084,94g 0,02g 6,6354 C08CA09 Lacidipine (O) 13646,304g 0,004g 6,9562 C08CA13 Lercanidipine (O) 27921,6g 0,01g 5,6932 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08D 2,5283 DIRECT CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 2,4340 C08DA01 Verapamil (O) 286472g 0,24g 2,4338 C08DA01 Verapamil (P) 26,35g 0,24g 0,0002 C08DB Benzothiazepine derivatives 0,0943 C08DB01 Diltiazem (O) 11100,6g 0,24g 0,0943 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 183,2492 C09A ACE INHIBITORS, PLAIN 95,6298 C09AA ACE inhibitors, plain 95,6298 C09AA01 Captopril (O) 3630g 0,05g 0,1480 C09AA02 Enalapril (O) 92241,52g 0,01g 18,8079 C09AA02 Enalapril (P) 8,1875g 0,01g 0,0017 C09AA03 Lisinopril (O) 1,12g 0,01g 0,0002 C09AA04 Perindopril (O) 1697,55g 0,004g 0,8653 C09AA05 Ramipril (O) 77067,79g 2,5mg 62,8560 C09AA06 Quinapril (O) 416,7g 15mg 0,0566 C09AA09 Fosinopril (O) 94229,8g 0,015g 12,8089 C09AA10 Trandolapril (O) 81,48g 0,002g 0,0831 C09AA15 Zofenopril (O) 29,4g 0,03g 0,0020 C09B ACE INHIBITORS, COMBINATIONS 29,3423 C09BA ACE inhibitors and diuretics 25,5305 C09BA02 Enalapril+ Hydrochlorothiazide (O) 7263644pieces 1pieces 14,8105 C09BA04 Perindopril+ Indapamide (O) 2030790pieces 1pieces 4,1408 C09BA05 Ramipril+ Hydrochlorothiazide (O) 1892266pieces 1pieces 3,8583 C09BA06 Quinapril+ Hydrochlorothiazide (O) 81240pieces 1pieces 0,1656 C09BA09 Fosinopril+ Hydrochlorothiazide (O) 1253232pieces 1pieces 2,5553 C09BB ACE inhibitors and calcium channel blockers 3,8118 C09BB03 Lisinopril+ Amlodipine (O) 1041720pieces 1pieces 2,1241 C09BB04 Perindopril+ Amlodipine (O) 258930pieces 1pieces 0,5280 C09BB07 Ramipril+ Amlodipine (O) 48240pieces 1pieces 0,0984 C09BB10 Trandolapril+ Verapamil (O) 520576pieces 1pieces 1,0614 C09C ANGIOTENSIN II ANTAGONISTS, PLAIN 38,4513 C09CA Angiotensin II antagonists, plain 38,4513

11/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C09CA01 Losartan (O) 179571,9g 0,05g 7,3229 C09CA02 Eprosartan (O) 7963,2g 0,6g 0,0271 C09CA03 Valsartan (O) 236922,56g 0,08g 6,0385 C09CA04 Irbesartan (O) 117,6g 0,15g 0,0016 C09CA06 Candesartan (O) 24253,152g 0,008g 6,1815 C09CA07 Telmisartan (O) 328072,64g 0,04g 16,7234 C09CA08 Olmesartan medoxomil (O) 21151,48g 0,02g 2,1564 C09D ANGIOTENSIN II ANTAGONISTS, COMBINATIONS 19,8258 C09DA Angiotensin II antagonists and diuretics 16,1030 C09DA01 Losartan+ Hydrochlorothiazide (O) 1940700pieces 1pieces 3,9571 C09DA03 Valsartan+ Hydrochlorothiazide (O) 888384pieces 1pieces 1,8114 C09DA06 Candesartan+ Hydrochlorothiazide (O) 726516pieces 1pieces 1,4814 C09DA07 Telmisartan+ Hydrochlorothiazide (O) 4249084pieces 1pieces 8,6638 C09DA08 Olmesartan medoxomil+ Hydrochlorothiazide (O) 92888pieces 1pieces 0,1894 C09DB Angiotensin II antagonists and calcium channel blockers 3,7228 C09DB01 Valsartan+ Amlodipine (O) 1204pieces 1pieces 0,0025 C09DB04 Telmisartan+ Amlodipine (O) 1824592pieces 1pieces 3,7203 C10 LIPID MODIFYING AGENTS 39,5692 C10A LIPID MODIFYING AGENTS, PLAIN 39,1795 C10AA HMG CoA reductase inhibitors 38,8463 C10AA01 Simvastatin (O) 110115,52g 0,03g 7,4841 C10AA03 Pravastatin (O) 8573,2g 0,03g 0,5827 C10AA04 Fluvastatin (O) 30228,8g 0,06g 1,0273 C10AA05 Atorvastatin (O) 101332,5g 0,02g 10,3308 C10AA07 Rosuvastatin (O) 95250,32g 0,01g 19,4214 C10AB Fibrates 0,1667 C10AB05 Fenofibrate (O) 11796g 0,2g 0,1203 C10AB08 Ciprofibrate (O) 2280g 0,1g 0,0465 C10AC Bile acid sequestrants 0,0007 C10AC01 Colestyramine (O) 4600g 14g 0,0007 C10AD Nicotinic acid and derivatives C10AD52 Nicotinic acid+ Laropiprant (O) 1148 pieces C10AX Other lipid modifying agents 0,1659 C10AX09 Ezetimibe (O) 813,4g 0,01g 0,1659 C10AX80 Omega-3-acid ethyl esters 90 (O) 42868 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 0,3897 C10BX HMG CoA reductase inhibitors, other combinations 0,3897 C10BX03 Atorvastatin+ Amlodipine (O) 191100pieces 1pieces 0,3897 D DERMATOLOGICALS 1,6175 D01 FOR DERMATOLOGICAL USE 1,0683 D01A ANTIFUNGALS FOR TOPICAL USE D01AC and derivatives D01AC01 (C) 970880 g D01AC05 (C) 181560 g D01AC08 (C) 491910 g D01AC08 Ketoconazole (C) 1900920 ml D01AC80 Isoconazole+ Diflucortolone (C) 512535 g D01AE Other antifungals for topical use D01AE15 Terbinafine (C) 687395 g D01AE16 Amorolfine (C) 13522,5 ml D01AE22 Naftifine (C) 310840 ml D01AE22 Naftifine (C) 359355 g D01AE80 Chornitrophenol (C) 125 ml D01B ANTIFUNGALS FOR SYSTEMIC USE 1,0683 D01BA Antifungals for systemic use 1,0683 D01BA01 Griseofulvin (O) 622,5g 0,5g 0,0025 D01BA02 Terbinafine (O) 130672,5g 0,25g 1,0658

12/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide (C) 493200 g D02AE Carbamide products D02AE01 Urea (C) 158100 g D02AF Salicylic acid preparations D02AF80 Salicylic acid+ Urea (C) 96400 g D02AF81 Salicylic acid+ (C) 207495 ml D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid (O) 3960 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol (C) 3544610 g D03AX81 Heparin sodium+ Allantoin+ Extract of Cepae (C) 144780 g D03AX82 hemoderivate of calf blood, deproteinized (C) 100 g D03AX83 Dexpanthenol+ (C) 819750 g D03B ENZYMES D03BA Proteolytic enzymes D03BA80 Collagenase+ (C) 120 g D05 ANTIPSORIATICS 0,0289 D05A ANTIPSORIATICS FOR TOPICAL USE D05AA Tars D05AA84 Tars (C) 1415700 ml D05AC Antracen derivatives D05AC01 Dithranol (C) 5000 g D05AX Other antipsoriatics for topical use D05AX02 Calcipotriol (C) 76920 g D05AX80 Calcipotriol+ Betamethasone (C) 582705 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0289 D05BB Retinoids for treatment of 0,0289 D05BB02 Acitretin (O) 495,3g 0,035g 0,0289 D05BX Other antipsoriatics for systemic use D05BX80 Dimethyl fumarate (O) 43,2 g AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AA Tetracycline and derivatives D06AA04 Tetracycline (C) 26000 g D06AX Other antibiotics for topical use D06AX01 Fusidic acid (C) 206475 g D06AX02 Chloramphenicol (C) 375 g D06AX13 Retapamulin (C) 1325 g D06AX80 Bacitracin+ Neomycin (C) 150900 g D06AX84 Chloramphenicol+ Methyluracil (C) 27600 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 sulfadiazine (C) 1741350 g D06BB Antivirals D06BB02 Tromantadine (C) 312 g D06BB03 Aciclovir (C) 173563 g D06BB04 Podophyllotoxin (C) 2358 ml D06BB06 Penciclovir (C) 37148 g D06BB10 Imiquimod (C) 2481 g D06BX Other chemotherapeutics

13/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D06BX01 (C) 141995 g CORTICOSTEROIDS, DERMATOLOGICAL D07 PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone (C) 313530 g D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone (C) 126840 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone (C) 387780 g D07AC04 Fluocinolone acetonide (C) 720 g D07AC13 Mometasone (C) 261180 ml D07AC13 Mometasone (C) 942860 g D07AC14 Methylprednisolone aceponate (C) 512260g D07AC17 Fluticasone (C) 74775 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol (C) 62850 ml D07AD01 Clobetasol (C) 656825 g CORTICOSTEROIDS, COMBINATIONS WITH D07B ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+ Chlorhexidine (C) 437320g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+ Salicylic acid (C) 374800 g D07BC80 Betamethasone+ Salicylic acid (C) 589800 ml CORTICOSTEROIDS, COMBINATIONS WITH D07C ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+ Fusidic acid (C) 92550 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+ Fusidic acid (C) 459840 g

D07CC81 Betamethasone+ Neomycin (C) 99720 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 Prednisolone+ Salicylic acid (C) 230400 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+ Salicylic acid (C) 232245 g D08 ANTISEPTICS AND D08A ANTISEPTICS AND DISINFECTANTS D08AC Biguanides and amidines D08AC02 Chlorhexidine (C) 31000 ml D08AC05 Polihexanide (C) 1170 ml D08AG products D08AG02 Povidone, iodinated (C) 760320 ml D08AG02 Povidone, iodinated (C) 2642640 g D08AG03 Iodine (C) 692150 ml D08AX Other antiseptics and disinfectants D08AX01 solution (C) 16000 ml D08AX82 Tar+ Castor oil+ Xeroformium (C) 39420 g D08AX83 Brilliant Green (C) 466790 ml D10 ANTI-ACNE PREPARATIONS 0,4720 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin (C) 31020 g D10AD03 Adapalene (C) 183810 g D10AE Peroxides

14/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D10AE01 Benzoyl peroxide (C) 21375 g D10AE01 Benzoyl peroxide (C) 410520 ml D10AF Antiinfectives for treatment of acne D10AF01 (C) 491700 ml D10AF02 Erythromycin (C) 157700 ml D10AF81 Clindamycin+ Benzoyl peroxide (C) 159555g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid (C) 427320 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,4720 D10BA Retinoids for treatment of acne 0,4720 D10BA01 Isotretinoin (O) 6944,4g 0,03g 0,4720 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,0484 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,0484 D11AH Agents for , excluding corticosteroids D11AH01 (C) 240 g D11AH02 (C) 94050 g D11AX Other dermatologicals 0,0484 D11AX01 Minoxidil (C) 16560 ml D11AX10 Finasteride (O) 23,744g 0,001g 0,0484 G GENITO URINARY SYSTEM AND SEX HORMONES 54,5351 G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,7679 ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,7679 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,0958 G01AA10 Clindamycin (V) 4698,2g 0,1g 0,0958 G01AA80 + Neomycin+ Polymyxin B (V) 654 pieces G01AF Imidazole derivatives 0,6639 G01AF01 Metronidazole (V) 24060g 0,5g 0,0981 G01AF02 Clotrimazole (V) 20420,4g 0,1g 0,4164 G01AF05 (V) 7329,75g 0,1g 0,1495 G01AX Other antiinfectives and antiseptics 0,0082 G01AX03 Policresulen (V) 360g 90mg 0,0082 G02 OTHER GYNECOLOGICALS 4,8762 G02A OXYTOCICS 0,0127 G02AB Ergot alkaloids 0,0089 G02AB01 Methylergometrine (P) 0,875g 0,2mg 0,0089 G02AD Prostaglandins 0,0037 G02AD02 Dinoprostone (P) 1,16 g G02AD02 Dinoprostone (V) 0,9158g 0,5mg 0,0037 G02AD06 Misoprostol (O) 5,4936 g G02B CONTRACEPTIVES FOR TOPICAL USE 3,6219 G02BA Intrauterine contraceptives 0,0068 G02BA03 Levonorgestrel (V) 3359pieces 1pieces 0,0068 G02BB Intravaginal contraceptives 3,6150 G02BB01 Etonogestrel+ Ethinylestradiol (V) 61432pieces 0,036pieces 3,4794 G02BB80 Nonoxinol (V) 5340pieces 1pieces 0,0109 G02BB81 (V) 61170pieces 1pieces 0,1247 G02BB81 Benzalkonium chloride (V) 119160 g G02C OTHER GYNECOLOGICALS 1,2417 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline (O) 11,66 g G02CA80 Hexoprenaline (P) 0,0603 g G02CB Prolactine inhibitors 0,1683 G02CB01 Bromocriptine (O) 391,5g 0,005g 0,1597 G02CB03 Cabergoline (O) 2,116g 0,5mg 0,0086 G02CX Other gynecologicals 1,0734 G02CX80 Extract of Agni casti fructus (O) 260580pieces 1pieces 0,5313 G02CX82 Extract of Cimicifuga racemosae (O) 531720pieces 2pieces 0,5421

15/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day SEX HORMONES AND MODULATORS OF THE GENITAL G03 37,7328 SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 29,9026 G03AA Progestogens and estrogens, fixed combinations 26,9602 G03AA09 Desogestrel+ Ethinylestradiol (O) 1043973pieces 0,75pieces 2,8382 G03AA10 Gestodene+ Ethinylestradiol (O) 71792pieces 1pieces 0,1464 G03AA10 Gestodene+ Ethinylestradiol (O) 2891301pieces 0,75pieces 7,8604 G03AA11 Norgestimate+ Ethinylestradiol (O) 63294pieces 0,75pieces 0,1721 G03AA12 Drospirenone+ Ethinylestradiol (O) 891828pieces 1pieces 1,8184 G03AA12 Drospirenone+ Ethinylestradiol (O) 3226902pieces 0,75pieces 8,7728 G03AA13 Norelgestromin+ Ethinylestradiol (TD) 118704pieces 0,107pieces 2,2620 G03AA14 Nomegestrol+ Estradiol (O) 27608pieces 1pieces 0,0563 G03AA15 Chlormadinone+ Ethinylestradiol (O) 196917pieces 0,75pieces 0,5353 G03AA81 Dienogest+ Ethinylestradiol (O) 918939pieces 0,75pieces 2,4983 G03AB Progestogens and estrogens, sequential preparations 0,7940 G03AB03 Levonorgestrel+ Ethinylestradiol (O) 228753pieces 0,75pieces 0,6219 G03AB05 Desogestrel+ Ethinylestradiol (O) 24024pieces 0,75pieces 0,0653 G03AB80 Dienogest+ Estradiol valerate (O) 52388pieces 1pieces 0,1068 G03AC Progestogens 2,0767 G03AC09 Desogestrel (O) 1018500pieces 1pieces 2,0767 G03AD Emergency contraceptives 0,0716 G03AD01 Levonorgestrel (O) 52,3005g 1,5mg 0,0711 G03AD02 Ulipristal (O) 7,56g 0,03g 0,0005 G03B ANDROGENS 0,2069 G03BA 3-oxoandrosten (4) derivatives 0,2069 G03BA03 Testosterone (C) 1950g 0,05g 0,0795 G03BA03 Testosterone (O) 1351,2g 0,12g 0,0230 G03BA03 Testosterone (P) 922g 0,018g 0,1044 G03C ESTROGENS 1,7478 G03CA Natural and semisynthetic estrogens, plain 1,5898 G03CA03 Estradiol (C, V) 161575 g G03CA03 Estradiol (O) 671,86g 2mg 0,6850 G03CA03 Estradiol (TD) 4,5388g 0,05mg 0,1851 G03CA03 Estradiol (TD) 23,338g 1mg 0,0476 G03CA03 Estradiol (V) 2,6408g 0,025mg 0,2154 G03CA04 Estriol (O) 0,36g 0,002g 0,0004 G03CA04 Estriol (TD) 0,0208 g G03CA04 Estriol (V) 44,7675g 0,2mg 0,4564 G03CA80 Estradiol+ Prednisolone (C) 89950 g G03CX Other estrogens 0,1580 G03CX01 Tibolone (O) 193,76g 2,5mg 0,1580 G03D PROGESTOGENS 1,9655 G03DA Pregnen (4) derivatives 1,0291 G03DA02 Medroxyprogesterone (O) 725,36g 0,005g 0,2958 G03DA02 Medroxyprogesterone (P) 745,245g 0,007g 0,2171 G03DA04 Progesterone (P) 936,375g 0,005g 0,3819 G03DA04 Progesterone (V) 5931,9g 0,09g 0,1344 G03DB Pregnadien derivatives 0,9363 G03DB01 Dydrogesterone (O) 4424,2g 0,01g 0,9021 G03DB08 Dienogest (O) 33,6g 2mg 0,0343 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,1602 G03FA Progestogens and estrogens, fixed combinations 1,5637 G03FA01 Norethisterone+ Estradiol (O) 644672pieces 1pieces 1,3145 G03FA17 Drospirenone+ Estradiol (O) 122248pieces 1pieces 0,2493 G03FB Progestogens and estrogens, sequential preparations 0,5965

16/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03FB05 Norethisterone+ Estradiol (O) 226268pieces 1pieces 0,4614 G03FB06 Medroxyprogesterone+ Estradiol (O) 168pieces 1pieces 0,0003 G03FB06 Medroxyprogesterone+ Estradiol (O) 252pieces 0,75pieces 0,0007 G03FB08 Dydrogesterone+ Estradiol (O) 65660pieces 1pieces 0,1339 G03FB80 Medroxyprogesterone+ Conjugated estrogens (O) 112pieces 1pieces 0,0002 GONADOTROPINS AND OTHER OVULATION G03G 0,4133 STIMULANTS G03GA Gonadotropins 0,1200 G03GA01 Chorionic gonadotrophin (P) 2970000U 250U 0,0242 G03GA05 Follitropin alfa (P) 2605275U 75U 0,0708 G03GA06 Follitropin beta (P) 629900U 75U 0,0171 G03GA07 Lutropin alfa (P) 45600U 75U 0,0012 G03GA08 Choriogonadotropin alfa (P) 0,806g 0,25mg 0,0066 G03GA09 Corifollitropin alfa (P) 0,0001g 0,15mg <0,0001 G03GB Ovulation stimulants, synthetic 0,2933 G03GB02 Clomifene (O) 1294,5g 0,009g 0,2933 G03H ANTIANDROGENS 1,3337 G03HA Antiandrogens, plain 0,3600 G03HA01 Cyproterone (O) 17655g 0,1g 0,3600 G03HB Antiandrogens and estrogens 0,9738 G03HB01 Cyproterone+ Estrogen (O) 358176pieces 0,75pieces 0,9738 OTHER SEX HORMONES AND MODULATORS OF THE G03X 0,0028 GENITAL SYSTEM G03XA Antigonadotropins and similar agents 0,0003 G03XA01 Danazol (O) 90g 0,6g 0,0003 G03XB Antiprogestogens 0,0025 G03XB01 Mifepristone (O) 741g 0,6g 0,0025 G04 UROLOGICALS 11,1581 G04B OTHER UROLOGICALS, INCL. ANTISPASMODICS 1,5774 G04BC Urinary concrement solvents 0,0003 G04BC80 Extract of Lespedesa capita (O) 1300ml 10ml 0,0003 G04BD Urinary antispasmodics 0,8890 G04BD04 Oxybutynin (O) 4754,1g 0,015g 0,6462 G04BD06 Propiverine (O) 11,27g 0,03g 0,0008 G04BD07 Tolterodine (O) 186,788g 0,004g 0,0952 G04BD09 Trospium chloride (O) 2880g 0,04g 0,1468 G04BE Drugs used in erectile dysfunction 0,6880 G04BE01 Alprostadil (P) 0,0343g 0,02mg 0,0035 G04BE01 Alprostadil (urethral) 0,572g 0,25mg 0,0047 G04BE03 Sildenafil (O) 13657,4g 0,05g 0,5569 G04BE08 Tadalafil (O) 429,2g 0,01g 0,0875 G04BE09 Vardenafil (O) 173,6g 0,01g 0,0354 G04BX Other urologicals 0,0001 G04BX14 Dapoxetin (O) 1,08g 0,03g 0,0001 G04BX90 Extr. prostatae (P) 0,15 g G04BX90 Extr. prostatae (R) 3360 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 9,5808 G04CA Alpha-adrenoreceptor antagonists 6,8368 G04CA01 Alfuzosin (O) 5823,6g 7,5mg 1,5832 G04CA02 Tamsulosin (O) 780,12g 0,4mg 3,9766 G04CA52 Tamsulosin+ Dutasteride (O) 626280pieces 1pieces 1,2770 G04CB Testosterone-5-alpha reductase inhibitors 0,4534 G04CB01 Finasteride (O) 388,87g 0,005g 0,1586 G04CB02 Dutasteride (O) 72,285g 0,5mg 0,2948 G04CX Other drugs used in benign prostatic hypertrophy 2,2906 G04CX02 Sabalis serrulatae fructus (O) 1123380pieces 1pieces 2,2906

17/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 21,4973 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,3600 ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND H01A 0,0844 ANALOGUES H01AA ACTH 0,0003 H01AA02 Tetracosactide (P) 0,035g 0,25mg 0,0003 H01AB Thyrotropin 0,0005 H01AB01 Thyrotropin (P) 1314,24U 5U 0,0005 H01AC Somatropin and somatropin agonists 0,0835 H01AC01 Somatropin (P) 81944,2197U 2U 0,0835 H01B POSTERIOR PITUITARY LOBE HORMONES 0,2144 H01BA Vasopressin and analogues 0,1004 H01BA01 Vasopressin injection (P) 1000U 4U 0,0005 H01BA02 Desmopressin (N) 0,267g 0,025mg 0,0218 H01BA02 Desmopressin (P) 0,0507g 0,004mg 0,0258 H01BA02 Desmopressin (SL) 6,1578g 0,24mg 0,0523 H01BB Oxytocin and analogues 0,1140 H01BB01 Demoxytocin (O) 4334500U 100U 0,0884 H01BB02 Oxytocin (P) 188250U 15U 0,0256 H01C HYPOTHALAMIC HORMONES 0,0612 H01CA Gonadotropin-releasing hormones 0,0067 H01CA01 Gonadorelin (P) 0,0043 g H01CA03 Histrelin (IMP) 0,45g 0,137mg 0,0067 H01CB Somatostatin and analogues 0,0426 H01CB02 Octreotide (P) 11,5325g 0,7mg 0,0336 H01CB03 Lanreotide (P) 13,2g 3mg 0,0090 H01CC Anti-gonadotropin-releasing hormones 0,0120 H01CC01 Ganirelix (P) 1,183g 0,25mg 0,0096

H01CC02 Cetrorelix (P) 0,2833g 0,25mg 0,0023 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 6,7326 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 6,7326 H02AA Mineralocorticoids 0,0997 H02AA02 Fludrocortisone (O) 4,89g 0,1mg 0,0997 H02AB Glucocorticoids 6,6329 H02AB01 Betamethasone (P) 17,784g 1,5mg 0,0242 H02AB02 Dexamethasone (O) 214,125g 1,5mg 0,2911 H02AB02 Dexamethasone (P) 595,7g 1,5mg 0,8097 H02AB04 Methylprednisolone (O) 5912,8g 7,5mg 1,6075 H02AB04 Methylprednisolone (P) 5387,43g 0,02g 0,5492 H02AB06 Prednisolone (O) 10949g 0,01g 2,2325 H02AB06 Prednisolone (P) 2650,675g 0,01g 0,5405 H02AB08 Triamcinolone (O) 61,4g 7,5mg 0,0167 H02AB08 Triamcinolone (P) 1239,84g 7,5mg 0,3371 H02AB09 Hydrocortisone (O) 2603g 0,03g 0,1769 H02AB09 Hydrocortisone (P) 607,2g 0,03g 0,0413 H02AB80 Hydrocortisone+ Lidocaine (P) 92,625g 0,03g 0,0063 H03 THYROID THERAPY 14,3807 H03A THYROID PREPARATIONS 13,1708 H03AA Thyroid hormones 13,1708 H03AA01 Levothyroxine sodium (O) 968,675g 0,15mg 13,1674 H03AA02 Liothyronine (O) 0,098g 0,06mg 0,0033 H03AA03 Levothyroxine sodium+ Liothyronine (O) 60pieces H03B ANTITHYROID PREPARATIONS 1,2099 H03BA Thiouracils 0,6410

18/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day H03BA02 Propylthiouracil (O) 31435g 0,1g 0,6410 H03BB Sulfur-containing imidazole derivatives 0,5690 H03BB02 Thiamazole (O) 2790,5g 0,01g 0,5690 H04 PANCREATIC HORMONES 0,0004 H04A GLYCOGENOLYTIC HORMONES 0,0004 H04AA Glycogenolytic hormones 0,0004 H04AA01 Glucagon (P) 0,208g 0,001g 0,0004 H05 CALCIUM HOMEOSTASIS 0,0236 H05B ANTI-PARATHYROID AGENTS 0,0236 H05BA Calcitonin preparations 0,0001 H05BA01 Calcitonin (salmon synthetic) (N) 11200U 200U 0,0001 H05BX Other anti-parathyroid agents 0,0235 H05BX01 Cinacalcet (O) 583,8g 0,06g 0,0198 H05BX02 Paricalcitol (O) 0,0035g 2mcg 0,0035 H05BX02 Paricalcitol (P) 0,0001g 2mcg 0,0001 J ANTIINFECTIVES FOR SYSTEMIC USE 17,8576 J01 ANTIBACTERIALS FOR SYSTEMIC USE 13,7181 J01A TETRACYCLINES 1,8613 J01AA Tetracyclines 1,8613 J01AA02 Doxycycline (O) 87467g 0,1g 1,7834 J01AA07 Tetracycline (O) 37872g 1g 0,0772 J01AA08 Minocycline (O) 14g 0,2g 0,0001 J01AA12 Tigecycline (P) 24g 0,1g 0,0005 J01C BETA-LACTAM ANTIBACTERIALS, 5,0587 J01CA Penicillins with extended spectrum 2,7602 J01CA01 Ampicillin (O) 15696g 2g 0,0160 J01CA01 Ampicillin (P) 28600g 2g 0,0292 J01CA04 Amoxicillin (O) 1331549,5g 1g 2,7150 J01CE Beta-lactamase sensitive penicillins 0,2508 J01CE01 Benzylpenicillin (P) 44400g 3,6g 0,0251 J01CE02 Phenoxymethylpenicillin (O) 220551,6g 2g 0,2249 J01CE08 Benzathine benzylpenicillin (P) 1245,6g 3,6g 0,0007 J01CE30 Benzylpenicillin+ Procaine benzylpenicillin (P) 86,58g 3,6g <0,0001 J01CF Beta-lactamase resistant penicillins 0,1482 J01CF04 Oxacillin (P) 145005g 2g 0,1478 J01CF05 Flucloxacillin (O) 322g 2g 0,0003 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 1,8997 J01CR01 Ampicillin+ Sulbactam (P) 165696g 2g 0,1689 J01CR02 Amoxicillin+ Clavulanic acid (O) 769414,45 g 1 g 1,5688 J01CR02 Amoxicillin+ Clavulanic acid (P) 68705g 3g 0,0467 J01CR04 Sultamicillin (O) 70642,5g 1,5g 0,0960 J01CR05 Piperacillin+ Tazobactam (P) 131764g 14g 0,0192 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,5221 J01DB First-generation 0,3076 J01DB04 Cefazolin (P) 104690g 3g 0,0712 J01DB05 Cefadroxil (O) 231937g 2g 0,2365 J01DC Second-generation cephalosporins 1,1006 J01DC01 Cefoxitin (P) 6067g 6g 0,0021 J01DC02 Cefuroxime (O) 182638g 0,5g 0,7448 J01DC02 Cefuroxime (P) 381313,5g 3g 0,2592 J01DC10 Cefprozil (O) 46375g 1g 0,0946 J01DD Third-generation cephalosporins 0,0575 J01DD01 Cefotaxime (P) 50753g 4g 0,0259 J01DD02 Ceftazidime (P) 36788g 4g 0,0188 J01DD04 Ceftriaxone (P) 12605g 2g 0,0129 J01DE Fourth-generation cephalosporins 0,0208 J01DE01 Cefepime (P) 20398g 2g 0,0208

19/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01DH 0,0356 J01DH02 Meropenem (P) 8585g 2g 0,0088 J01DH03 Ertapenem (P) 7412g 1g 0,0151 J01DH04 Doripenem (P) 50g 1,5g 0,0001 J01DH51 + Cilastatin (P) 11450g 2g 0,0117 J01E SULFONAMIDES AND TRIMETHOPRIM 0,5140 J01EA Trimethoprim and derivatives 0,0275 J01EA01 Trimethoprim (O) 5397g 0,4g 0,0275 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,4865 derivatives J01EE01 Sulfamethoxazole+ Trimethoprim (O) 19920pieces 4pieces 0,0102 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 412720pieces 2pieces 0,4208 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 1041200ml 40ml 0,0531 J01EE01 Sulfamethoxazole+ Trimethoprim (P) 24550ml 20ml 0,0025 J01F , LINCOSAMIDES AND STREPTOGRAMINS 2,6445 J01FA Macrolides 2,4682 J01FA01 Erythromycin (O) 50g 1g 0,0001 J01FA02 Spiramycin (O) 17020g 3g 0,0116 J01FA09 Clarithromycin (O) 459230,5g 0,5g 1,8727 J01FA09 Clarithromycin (P) 1579g 1g 0,0032 J01FA10 Azithromycin (O) 85418,4g 0,3g 0,5806 J01FA10 Azithromycin (P) 5g 0,5g <0,0001 J01FF Lincosamides 0,1763 J01FF01 Clindamycin (O) 93182,4g 1,2g 0,1583 J01FF01 Clindamycin (P) 15846,3g 1,8g 0,0180 J01G AMINOGLYCOSIDE ANTIBACTERIALS 0,0584 J01GB Other aminoglycosides 0,0584 J01GB01 Tobramycin (I) 969,248g 0,3g 0,0066 J01GB01 Tobramycin (P) 40g 0,24g 0,0003 J01GB03 Gentamicin (P) 4548,8g 0,24g 0,0386 J01GB06 Amikacin (P) 6315g 1g 0,0129 J01M QUINOLONE ANTIBACTERIALS 1,1529 J01MA Fluoroquinolones 1,1529 J01MA01 (O) 12366g 0,4g 0,0630 J01MA02 (O) 310702,5g 1g 0,6335 J01MA02 Ciprofloxacin (P) 12661g 0,5g 0,0516 J01MA06 Norfloxacin (O) 101696g 0,8g 0,2592 J01MA12 (O) 26993,25g 0,5g 0,1101 J01MA12 Levofloxacin (P) 202g 0,5g 0,0008 J01MA14 Moxifloxacin (O) 6700g 0,4g 0,0342 J01MA14 Moxifloxacin (P) 87,6g 0,4g 0,0004 J01X OTHER ANTIBACTERIALS 0,9062 J01XA Glycopeptide antibacterials 0,0137 J01XA01 Vancomycin (P) 13422g 2g 0,0137 J01XB Polymyxins 0,0022 J01XB01 Colistin (I, P) 3200000000U 3000000U 0,0022 J01XC Steroid antibacterials 0,0003 J01XC01 Fusidic acid (O) 254g 1,5g 0,0003 J01XD Imidazole derivatives 0,3420 J01XD01 Metronidazole (O) 299875g 2g 0,3057 J01XD01 Metronidazole (P) 26696,5g 1,5g 0,0363 J01XE derivatives 0,5442 J01XE01 Nitrofurantoin (O) 53381g 0,2g 0,5442 J01XX Other antibacterials 0,0038 J01XX01 Fosfomycin (O) 135g 3g 0,0001 J01XX01 Fosfomycin (P) 250g 8g 0,0001 J01XX07 Nitroxoline (O) 182,5g 1g 0,0004

20/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01XX08 Linezolid (O) 1530g 1,2g 0,0026 J01XX08 Linezolid (P) 390g 1,2g 0,0007 J01XX81 Dioxydine (NA) 269 g J01XX81 Dioxydine (P) 45 g J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3678 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3678 J02AA Antibiotics 0,0048 J02AA01 Amphotericin (O) 264 g J02AA01 Amphotericin (P) 81,95g 0,035g 0,0048 J02AB Imidazole derivatives 0,1044 J02AB02 Ketoconazole (O) 10236g 0,2g 0,1044 J02AC Triazole derivatives 0,2560 J02AC01 Fluconazole (O) 11021,65g 0,2g 0,1124 J02AC01 Fluconazole (P) 1946,3g 0,2g 0,0198 J02AC02 Itraconazole (O) 11711,2g 0,2g 0,1194 J02AC03 Voriconazole (O) 739,2g 0,4g 0,0038 J02AC03 Voriconazole (P) 86,4g 0,4g 0,0004 J02AC04 Posaconazole (O) 75,6g 0,8g 0,0002 J02AX Other antimycotics for systemic use 0,0027 J02AX04 Caspofungin (P) 64,77g 0,05g 0,0026 J02AX06 Anidulafungin (P) 1,5g 0,1g <0,0001 J04 ANTIMYCOBACTERIALS 0,3664 J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,3493 J04AA Aminosalicylic acid and derivatives 0,0142 J04AA01 Aminosalicylic acid (O) 48000g 12g 0,0082 J04AA02 Sodium aminosalicylate (O) 41400g 14g 0,0060 J04AB Antibiotics 0,0838 J04AB01 Cycloserine (O) 10000g 0,75g 0,0272 J04AB02 Rifampicin (O) 7650g 0,6g 0,0260 J04AB02 Rifampicin (P) 18g 0,6g 0,0001 J04AB30 Capreomycin (P) 15000g 1g 0,0306 J04AC Hydrazides 0,0836 J04AC01 Isoniazid (O) 12300g 0,3g 0,0836 J04AD Thiocarbamide derivatives 0,0408 J04AD01 Protionamide (O) 15000g 0,75g 0,0408 J04AK Other drugs for treatment of tuberculosis 0,0612 J04AK01 Pyrazinamide (O) 45000g 1,5g 0,0612 J04AM Combinations of drugs for treatment of tuberculosis 0,0658 J04AM02 Rifampicin+ Isoniazid (O) 64500pieces 2pieces 0,0658 J04B DRUGS FOR TREATMENT OF LEPRA 0,0171 J04BA Drugs for treatment of lepra 0,0171 J04BA02 Dapsone (O) 420g 0,05g 0,0171 J05 ANTIVIRALS FOR SYSTEMIC USE 3,4052 J05A DIRECT ACTING ANTIVIRALS 3,4052 Nucleosides and nucleotides excl. reverse transcriptase J05AB 0,3141 inhibitors J05AB01 Aciclovir (O) 87152g 4g 0,0444 J05AB01 Aciclovir (P) 2722,5g 4g 0,0014 J05AB04 Ribavirin (O) 85982,4g 1g 0,1753 J05AB06 Ganciclovir (P) 267,5g 0,5g 0,0011 J05AB09 Famciclovir (O) 56g 0,75g 0,0002 J05AB11 Valaciclovir (O) 125065g 3g 0,0850 J05AB14 Valganciclovir (O) 2970g 0,9g 0,0067 J05AC Cyclic amines J05AC02 Rimantadine (O) 45 g J05AD Phosphonic acid derivatives 0,0002 J05AD01 Foscarnet sodium (P) 600g 6,5g 0,0002 J05AE Protease inhibitors 0,8350

21/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J05AE03 Ritonavir (O) 24102g 1,2g 0,0410 J05AE04 Nelfinavir (O) 9855g 2,25g 0,0089 J05AE07 Fosamprenavir (O) 128730g 1,4g 0,1875 J05AE08 Atazanavir (O) 5238g 0,3g 0,0356 J05AE10 Darunavir (O) 55584g 1,2g 0,0944 J05AE11 Telaprevir (O) 4914 g J05AE80 Lopinavir+ Ritonavir (O) 177120g 0,8g 0,4514 J05AE81 Boceprevir (O) 6350,4g 0,8g 0,0162 J05AF Nucleoside and nucleotide reverse transcriptase inhibitors 0,1986 J05AF01 Zidovudine (O) 3744g 0,6g 0,0127 J05AF01 Zidovudine (P) 65g 0,6g 0,0002 J05AF02 Didanosine (O) 17676g 0,4g 0,0901 J05AF05 Lamivudine (O) 12942,8g 0,3g 0,0880 J05AF06 Abacavir (O) 2006,4g 0,6g 0,0068 J05AF10 Entecavir (O) 0,195g 0,5mg 0,0008 J05AG Non-nucleoside reverse transcriptase inhibitors 0,5791 J05AG01 Nevirapine (O) 7488g 0,4g 0,0382 J05AG03 Efavirenz (O) 159165g 0,6g 0,5409 J05AG05 Rilpivirine (O) 12,75 g J05AH Neuraminidase inhibitors 0,0111 J05AH01 Zanamivir (I) 2,6g 0,02g 0,0003 J05AH02 Oseltamivir (O) 794,25g 0,15g 0,0108 J05AR Antivirals for treatment of HIV , combinations 1,4364 J05AR01 Zidovudine+ Lamivudine (O) 472200pieces 2pieces 0,4814 J05AR02 Lamivudine+ Abacavir (O) 367410pieces 1pieces 0,7491 J05AR03 Tenofovir disoproxil+ Emtricitabine (O) 100980pieces 1pieces 0,2059 J05AX Other antivirals 0,0307 J05AX08 Raltegravir (O) 11570g 0,8g 0,0295 J05AX09 Maraviroc (O) 360g 0,6g 0,0012 J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA03 Snake venom antiserum (P) 10 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a (P) 2969,85g

J06BA02 Immunoglobulins, normal human, for intravascular a (P) 20215g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin (P) 2497500U J06BB03 Varicella zoster immunoglobulin (P) 625 U J06BB04 Hepatitis B immunoglobulin (P) 2400 U J06BB05 Rabies immunoglobulin (P) 3300 U J06BB09 Cytomegalovirus immunoglobulin (P) 122 g J06BB16 Palivizumab (P) 35,5 g J07 VACCINES J07A BACTERIAL VACCINES J07AE Cholera vaccines J07AE01 Cholera, inactivated, whole cell (O) 16 doses J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified antigen conjugated (P) 53pieces J07AH Meningococcal vaccines Neisseria meningitidis (strain A4) group A+ Neisseria J07AH03 330 doses meningitidis (strain C2241) group C (P) J07AL Pneumococcal vaccines

22/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J07AL01 Pneumococcus, purified polysaccharides antigen (P) 209doses Pneumococcus, purified polysaccharides antigen conjugated J07AL02 628 doses (P) Pneumococcus, purified polysaccharides antigen+ J07AL52 757 doses Haemophilus influenzae, conjugated (P) J07AM Tetanus vaccines J07AM01 Tetanus vaccine (adsorbed) (P) 121 doses J07AM51 Tetanus vaccine (adsorbed)+ Diphtheria vaccine (P) 31450doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated (P) 2620 pieces J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen (P) 1649 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis (P) 23132 doses J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole virus (P) 75374doses J07BB Influenza vaccines J07BB02 Influenza, purified antigen (P) 25142 doses J07BC Hepatitis vaccines J07BC01 Hepatitis B, purified antigen (P) 74594 doses J07BC02 Hepatitis A, inactivated, whole virus (P) 7386 doses J07BC20 Combinations+ Hepatitis B virus surface antigen (P) 5637doses J07BD Measles vaccines Morbilli, live attenuated+ Rubella, live attenuated+ Mumps, J07BD52 27667 doses live,attenuated (P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus (P) 463doses J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus (P) 3216 doses J07BH Rota virus diarrhea vaccines J07BH01 Rota virus, live attenuated (O) 3886 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated (P) 466 doses J07BL Yellow fever vaccines J07BL01 Yellow fever, live attenuated (P) 1419 doses J07BM Papillomavirus vaccines J07BM01 Human papillomavirus (P) 1341 doses J07BM02 Human papillomavirus (P) 1804 doses J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+ Pertussis vaccine+ Tetanus vaccine J07CA02 (adsorbed)+ Poliomyelitis, inactivated, type 1+ Poliomyelitis, 34620 doses inactivated, type 2+ Poliomyelitis, inactivated, type 3 (P)

Diphtheria toxoid+ Poliomyelitis+ Haemophilus influenzae B, J07CA82 purified antigen conjugated+ Pertussis toxoid+ Clostridium 360 doses vaccine (P) Diphtheria toxoid+ Clostridium vaccine+ Poliomyelitis, J07CA86 inactivated, type 1+ Poliomyelitis, inactivated, type 2+ 132 doses Poliomyelitis, inactivated, type 3 (P)

Diphtheria toxoid+ Clostridium vaccine+ Pertussis toxoid+ Pertussis filamentous haemogglutinin (FHA)+ Poliomyelitis, J07CA87 inactivated, type 1+ Poliomyelitis, inactivated, type 2+ 55100 doses Poliomyelitis, inactivated, type 3+ Haemophilus influenzae B, purified antigen conjugate (P)

23/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Diphtheria toxoid+ Clostridium vaccine+ Pertussis toxoid+ Pertussis filamentous haemogglutinin (FHA)+ Poliomyelitis, J07CA88 1450 doses inactivated, type 1+ Poliomyelitis, inactivated, type 2+ Poliomyelitis, inactivated, type 3 (P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 8,5797 L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide (O) 792,5 g L01AA01 Cyclophosphamide (P) 4711 g L01AA02 Chlorambucil (O) 37,95 g L01AA03 Melphalan (O) 13,3 g L01AA03 Melphalan (P) 21 g L01AA06 Ifosfamide (P) 2080 g L01AA09 Bendamustine (P) 75 g L01AB Alkyl sulfonates L01AB01 Busulfan (O) 0,8 g L01AB02 Treosulfan (P) 380 g L01AC Ethylene imines L01AC01 Thiotepa (P) 1,16 g L01AD Nitrosoureas L01AD01 Carmustine (P) 18 g L01AD02 Lomustine (O) 37,2 g L01AX Other alkylating agents L01AX03 Temozolomide (O) 377,475 g L01AX04 Dacarbazine (P) 265 g L01B L01BA Folic acid analogues L01BA01 (P) 1966,44 g L01BA04 Pemetrexed (P) 175,9 g L01BB Purine analogues L01BB02 Mercaptopurine (O) 556,25 g L01BB03 Tioguanine (O) 25 g L01BB04 (P) 0,66 g L01BB05 Fludarabine (O) 2 g L01BB05 Fludarabine (P) 217,75 g L01BB06 Clofarabine (P) 0,3 g L01BC Pyrimidine analogues L01BC01 Cytarabine (P) 1881,6 g L01BC02 Fluorouracil (P) 10470 g L01BC05 Gemcitabine (P) 5062,5 g L01BC06 Capecitabine (O) 249318 g L01BC07 Azacitidine (P) 39,2 g L01BC08 Decitabine (P) 6,25 g L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine (P) 3,14 g L01CA02 Vincristine (P) 2,405 g L01CA03 Vindesine (P) 0,015 g L01CA04 Vinorelbine (P) 14,4 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide (O) 301 g L01CB01 Etoposide (P) 731 g L01CD Taxanes L01CD01 Paclitaxel (P) 666,282 g L01CD02 Docetaxel (P) 317,6 g

24/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin (P) 0,025 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin (P) 126,8 g L01DB02 Daunorubicin (P) 12,08 g L01DB03 Epirubicin (P) 307,2 g L01DB06 Idarubicin (P) 1,515 g L01DB07 (P) 2,75 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin (P) 0,15 g L01DC01 Bleomycin (P) 12750000 U L01DC03 Mitomycin (P) 4,77 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin (P) 324,5 g L01XA02 Carboplatin (P) 1516,35 g L01XA03 Oxaliplatin (P) 542,9 g L01XB Methylhydrazines L01XB01 Procarbazine (O) 172,5 g L01XC Monoclonal L01XC02 (P) 1067,9 g L01XC03 Trastuzumab (P) 953,4 g L01XC04 (P) 0,27 g L01XC06 Cetuximab (P) 34,3 g L01XC07 Bevacizumab (P) 829,2 g L01XC10 Ofatumumab (P) 9,6 g L01XC12 brentuksimabvedotiin (P) 1 g L01XE Protein kinase inhibitors L01XE01 Imatinib (O) 8712 g L01XE02 Gefitinib (O) 405 g L01XE03 Erlotinib (O) 388,5 g L01XE04 Sunitinib (O) 437,85 g L01XE05 Sorafenib (O) 5689,6 g L01XE06 Dasatinib (O) 306 g L01XE08 Nilotinib (O) 4508,8 g L01XE09 (P) 0,72 g L01XE10 (O) 21,3 g L01XE11 Pazopanib (O) 522 g L01XE80 Ruxolitinib (O) 54 g L01XX Other antineoplastic agents L01XX01 Amsacrine (P) 7,65 g L01XX02 Asparaginase (P) 2050000 U L01XX05 Hydroxycarbamide (O) 159000 g L01XX11 Estramustine (O) 588 g L01XX14 Tretinoin (O) 77 g L01XX17 Topotecan (P) 2,816 g L01XX19 Irinotecan (P) 436,48 g L01XX24 Pegaspargase (P) 236250 U L01XX32 Bortezomib (P) 2,373 g L01XX35 Anagrelide (O) 0,55 g L01XX38 Vorinostat (O) 48 g L01XX41 Eribulin (P) 0,0264 g L02 ENDOCRINE THERAPY 3,7902 L02A HORMONES AND RELATED AGENTS 0,1291 L02AB Progestogens 0,0113 L02AB02 Medroxyprogesterone (O) 5520g 1g 0,0113

25/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L02AE Gonadotropin releasing hormone analogues 0,1178 L02AE01 Buserelin (N) 6,21g 1,2mg 0,0106 L02AE03 Goserelin (P) 4,0284g 0,129mg 0,0637 L02AE04 Triptorelin (P) 2,8669g 0,134mg 0,0436 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 3,6611 L02BA Anti-estrogens 0,5144 L02BA01 Tamoxifen (O) 4461g 0,02g 0,4548 L02BA03 Fulvestrant (P) 242,5g 8,3mg 0,0596 L02BB Anti-androgens 1,9348 L02BB03 (O) 47444,6g 0,05g 1,9348 L02BG Aromatase inhibitors 1,2119 L02BG03 Anastrozole (O) 236,544g 1mg 0,4823 L02BG04 Letrozole (O) 783,675g 2,5mg 0,6392 L02BG06 Exemestane (O) 1109,25g 0,025g 0,0905 L02BX Other hormone antagonists and related agents L02BX03 Abiraterone (O) 2940 g L03 IMMUNOSTIMULANTS 0,8787 L03A IMMUNOSTIMULANTS 0,8787 L03AA Colony stimulating factors 0,0385 L03AA02 Filgrastim (P) 3,2156g 0,35mg 0,0187 L03AA10 Lenograstim (P) 0,0053g 0,35mg <0,0001 L03AA13 Pegfilgrastim (P) 2,898g 0,3mg 0,0197 L03AB 0,7501 L03AB04 alfa-2a (P) 36039000000U 2000000U 0,0367 L03AB07 Interferon beta-1a (P) 0,8841g 0,0043mg 0,4192 L03AB08 Interferon beta-1b (P) 1,8648E+11U 4000000U 0,0951 L03AB10 Peginterferon alfa-2b (P) 0,3636g 0,0075mg 0,0988 L03AB11 Peginterferon alfa-2a (P) 1,2785g 0,026mg 0,1003 L03AC Interleukins <0,0001 L03AC01 Aldesleukin (P) 0,0022g 0,2mg <0,0001 L03AX Other immunostimulants 0,0901 L03AX03 BCG bacteria (P) 12200 ml L03AX13 (P) 883,68g 0,02g 0,0901 L03AX16 Plerixafor (P) 0,216g 16,8mg <0,0001 L03AX80 Methyluracil (O) 2500 g L03AX80 Methyluracil (R) 15 g L04 IMMUNOSUPPRESSANTS 3,9108 L04A IMMUNOSUPPRESSANTS 3,9108 L04AA Selective immunosuppressants 0,6288 L04AA04 Rabbit anti-T-lymphocyte immunoglobulin (P) 14,5g 0,1g 0,0003 L04AA06 (O) 210189,4g 2g 0,2143 L04AA06 Mycophenolic acid (P) 100g 2g 0,0001 L04AA10 (O) 26,16g 0,003g 0,0178 L04AA13 (O) 3784,2g 0,02g 0,3858 L04AA18 Everolimus (O) 0,265g 1,5mg 0,0004 L04AA24 (P) 43g 0,027g 0,0032 L04AA26 (P) 10,8 g L04AA27 (O) 1,708g 0,5mg 0,0070 L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 0,4561 L04AB01 (P) 400,24g 0,007g 0,1166 L04AB02 (P) 291g 3,75mg 0,1582 L04AB04 (P) 194,08g 2,9mg 0,1365 L04AB05 (P) 43,2g 14mg 0,0063 L04AB06 (P) 31,4g 1,66mg 0,0386 L04AC Interleukin inhibitors 0,0401 L04AC02 (P) 1,84g 0,04g 0,0001 L04AC03 (P) 42,21g 0,1g 0,0009 L04AC05 (P) 2,925g 0,54mg 0,0110

26/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L04AC07 (P) 275,44g 0,02g 0,0281 L04AD inhibitors 0,2739 L04AD01 (O) 26807,5g 0,25g 0,2186 L04AD01 Ciclosporin (P) 75g 0,25g 0,0006 L04AD02 Tacrolimus (O) 134,06g 5mg 0,0547 L04AX Other immunosuppressants 2,5119 L04AX01 (O) 20795g 0,15g 0,2827 L04AX02 (O) 1266g 0,1g 0,0258 L04AX03 Methotrexate (O) 2670,75g 2,5mg 2,1782 L04AX04 (O) 123,27g 0,01g 0,0251 M MUSCULO-SKELETAL SYSTEM 69,3945 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 60,9916 ANTIINFLAMMATORY AND ANTIRHEUMATIC M01A 60,9749 PRODUCTS, NON-STEROIDS M01AB derivatives and related substances 13,4230 M01AB01 Indometacin (O) 11214,5g 0,1g 0,2287 M01AB01 Indometacin (P) 3,6g 0,1g 0,0001 M01AB05 Diclofenac (O) 588483,5g 0,1g 11,9991 M01AB05 Diclofenac (P) 28186,5g 0,1g 0,5747 M01AB05 Diclofenac (R) 26718g 0,1g 0,5448 M01AB16 Aceclofenac (O) 1768g 0,2g 0,0180 M01AB80 Diclofenac+ Misoprostol (O) 2829g 0,1g 0,0577 M01AC Oxicams 5,9700 M01AC01 Piroxicam (O) 1761,2g 0,02g 0,1796 M01AC05 Lornoxicam (O) 5499,92g 0,012g 0,9345 M01AC05 Lornoxicam (P) 36,8g 0,012g 0,0063 M01AC06 Meloxicam (O) 35323,125g 0,015g 4,8016 M01AC06 Meloxicam (P) 354,225g 0,015g 0,0482 M01AE Propionic acid derivatives 27,8157 M01AE01 Ibuprofen (O) 13756060,8g 1,2g 23,3737 M01AE02 Naproxen (O) 106233,5g 0,5g 0,4332 M01AE03 Ketoprofen (O) 60251,875g 0,15g 0,8190 M01AE03 Ketoprofen (P) 17099g 0,15g 0,2324 M01AE09 Flurbiprofen (O) 48g 0,2g 0,0005 M01AE11 Tiaprofenic acid (O) 30g 0,6g 0,0001 M01AE17 Dexketoprofen (O) 19059,5g 0,075g 0,5182 M01AE17 Dexketoprofen (P) 2177g 0,075g 0,0592 M01AE52 Naproxen+ Esomeprazole (O) 583485g 0,5g 2,3794 M01AG Fenamates 0,0015 M01AG02 Tolfenamic acid (O) 228g 0,3g 0,0015 M01AH Coxibs 3,7243 M01AH01 Celecoxib (O) 36533g 0,2g 0,3725 M01AH05 Etoricoxib (O) 98631,96g 60mg 3,3518 Other antiinflammatory and antirheumatic agents, non- M01AX 10,0403 steroids M01AX01 Nabumetone (O) 247120g 1g 0,5039 M01AX05 Glucosamine (O) 7015558,38g 1,5g 9,5364 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0167 M01CC Penicillamine and similar agents 0,0167 M01CC01 Penicillamine (O) 4100g 0,5g 0,0167

M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR

M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

M02AA Antiinflammatory preparations, non-steroids for topical use

27/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M02AA07 Piroxicam (C) 54800 g M02AA10 Ketoprofen (C) 2276870 g M02AA12 Naproxen (C) 476740 g M02AA13 Ibuprofen (C) 2088350 g M02AA15 Diclofenac (C) 23487315 g M02AA15 Diclofenac (TD) 220750 pieces M02AA23 Indometacin (C) 11800 ml M02AA23 Indometacin (C) 187450 g M02AA81 Ibuprofen+ Levomenthol (C) 1169650 g M02AC Preparations with salicylic acid derivatives Methyl salicylate+ Menthol+ Eucalyptus oil+ Turpentine oil M02AC80 298552 g (C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+ Nonivamide (C) 230320 g M02AX85 Camphor (C) 10400 ml M02AX86 Camphor+ Methyl salicylate+ Menthol (C) 51450 g Camphor+ Salicylic acid+ Turpentine oil+ Venenum Viperae M02AX90 1405500 g berus (C) Benzyl nicotinate+ Nonivamide+ Camphor+ Turpentine oil+ M02AX92 1120870 g Dimethyl sulfoxide (C) M03 MUSCLE RELAXANTS 0,6899 M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 Suxamethonium chloride (P) 4710 g M03AC Other quaternary ammonium compounds M03AC04 Atracurium besilate (P) 1847,5 g M03AC06 Pipecuronium bromide (P) 36,4 g M03AC09 Rocuronium bromide (P) 207 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum toxin (P) 400400 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,6899 M03BX Other centrally acting agents 0,6899 M03BX01 (O) 3469g 0,05g 0,1415 M03BX01 Baclofen (P) 0,002g 0,55mg <0,0001 M03BX02 Tizanidine (O) 3206,4g 0,012g 0,5448 M03BX04 Tolperisone (O) 351g 0,2g 0,0036 M03C MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS M03CA Dantrolene and derivatives M03CA01 Dantrolene (P) 0,96 g M04 ANTIGOUT PREPARATIONS 2,9131 M04A ANTIGOUT PREPARATIONS 2,9131 M04AA Preparations inhibiting uric acid production 2,8988 M04AA01 Allopurinol (O) 568675g 0,4g 2,8988 M04AB Preparations increasing uric acid excretion 0,0143 M04AB03 Benzbromarone (O) 700g 0,1g 0,0143 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,8000 DRUGS AFFECTING BONE STRUCTURE AND M05B 4,8000 MINERALIZATION M05BA Bisphosphonates 2,4163 M05BA02 Clodronic acid (P) 6g 1,5g <0,0001 M05BA03 Pamidronic acid (P) 111g 0,06g 0,0038 M05BA04 Alendronic acid (O) 4512,76g 0,01g 0,9201 M05BA06 Ibandronic acid (O) 2363,85g 0,005g 0,9640 M05BA06 Ibandronic acid (P) 6,396g 0,006g 0,0022 M05BA07 Risedronic acid (O) 1283,94g 0,005g 0,5236 M05BA08 Zoledronic acid (P) 5,112g 0,004g 0,0026 M05BB Bisphosphonates, combinations 2,1898

28/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M05BB03 Alendronic acid+ Colecalciferol (O) 10739,68g 10mg 2,1898 M05BX Other drugs affecting bone structure and mineralization 0,1939 M05BX03 Strontium ranelate (O) 90664g 2g 0,0924 M05BX04 Denosumab (P) 16,424g 0,33mg 0,1015 N NERVOUS SYSTEM 97,6758 N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AA Ethers N01AA01 Ether, anesthetic (I) 9730950 ml N01AB Halogenated hydrocarbons N01AB06 Isoflurane (I) 101100 ml N01AB07 (I) 4320 ml N01AB08 (I) 624250 ml N01AF , plain N01AF03 Thiopental (P) 8750 g N01AH Opioid anesthetics N01AH01 Fentanyl (P) 48,7275 g N01AH06 Remifentanil (P) 5,165 g N01AX Other general anesthetics N01AX01 Droperidol (P) 33,675 g N01AX03 Ketamine (P) 397 g N01AX07 (P) 172,4 g N01AX10 (P) 33372 g N01AX11 (P) 10560 g N01B ANESTHETICS, LOCAL N01BA Esters of aminobenzoic acid N01BA02 Procaine (P) 54 g N01BB Amides N01BB01 Bupivacaine (P) 3055,65 g N01BB02 Lidocaine (NA) 20940 g N01BB02 Lidocaine (NA) 125800 ml N01BB02 Lidocaine (P) 22748 g N01BB02 Lidocaine (P, V) 616 g N01BB03 Mepivacaine (dental) 1412,1 g N01BB09 Ropivacaine (P) 6 g N01BB80 Articaine+ Epinephrine (dental) 1005210 ml N01BB80 Articaine+ Epinephrine (O) 82350 ml N01BB81 Bupivacaine+ Epinephrine (P) 264600 ml N01BB82 Lidocaine+ Epinephrine (P) 54400 ml N01BB83 Lidocaine+ Prilocaine (dental) 340 g N01BB83 Lidocaine+ Prilocaine (C) 40025 g N01BB86 Lidocaine+ Chlorhexidine (urethral) 932637,5g N01BB89 Lidocaine+ Norepinephrine (dental) 48870 ml N01BB90 Lidocaine+ Paraformaldehyde (dental) 549g N01BB91 Lidocaine+ Ephedrine+ Arsenic trioxide (dental) 598 g N01BC Esters of benzoic acid N01BC01 Cocaine (C) 575 g N02 ANALGESICS 14,1170 N02A OPIOIDS 3,1785 N02AA Natural opium alkaloids 1,2402 N02AA01 (O) 5560,5g 0,1g 0,1134 N02AA01 Morphine (P) 649,6g 0,03g 0,0442 N02AA05 Oxycodone (O) 4308,08g 0,075g 0,1171 N02AA08 Dihydrocodeine (O) 3015,6g 0,15g 0,0410 N02AA80 Codeine+ Paracetamol (O) 1360386pieces 3pieces 0,9246 N02AA82 Oripavine (NA) 900 g N02AB Phenylpiperidine derivatives 0,0825

29/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N02AB02 Pethidine (P, V) 3834g 0,4g 0,0195 N02AB03 Fentanyl (N) 0,0624g 0,6mg 0,0002 N02AB03 Fentanyl (SL) 1,2g 0,6mg 0,0041 N02AB03 Fentanyl (TD) 34,5348g 1,2mg 0,0587 N02AX Other opioids 1,8557 N02AX02 Tramadol (O) 254662g 0,3g 1,7308 N02AX02 Tramadol (P) 11594g 0,3g 0,0788 N02AX02 Tramadol (R) 885,5g 0,3g 0,0060 N02AX52 Tramadol+ Paracetamol (O) 2948,25g 150mg 0,0401 N02B OTHER ANALGESICS AND ANTIPYRETICS 10,5222 N02BA Salicylic acid and derivatives 1,4423 N02BA01 Acetylsalicylic acid (O) 1860299,28g 3g 1,2644 N02BA80 Acetylsalicylic acid + Ascorbic acid (O) 261843,9g 3g 0,1780 N02BB Pyrazolones 0,0081 N02BB02 Metamizole sodium (O) 740g 3g 0,0005 N02BB02 Metamizole sodium (P) 6450g 3g 0,0044 N02BB02 Metamizole sodium (P, V) 4730g 3g 0,0032 N02BE Anilides 9,0541 N02BE01 Paracetamol (O) 8083171,9g 3g 5,4938 N02BE01 Paracetamol (P) 152940g 3g 0,1039 N02BE01 Paracetamol (R) 105564,7g 3g 0,0717 N02BE76 Paracetamol+ Caffeine+ Phenylephrine (O) 60102g 3g 0,0408 Paracetamol+ Chlorphenamine+ Pseudoephedrine+ N02BE81 469752g 3g 0,3193 Dextromethorphan (O) N02BE83 Paracetamol+ Caffeine (O) 185400g 3g 0,1260 N02BE84 Paracetamol+ Phenylephrine+ Ascorbic acid (O) 1003582,25g 3g 0,6821 N02BE85 Paracetamol+ Pheniramine+ Ascorbic acid (O) 211481,12g 3g 0,1437 Paracetamol+ Phenylephrine+ Terpin hydrate+ Ascorbic N02BE86 373470g 3g 0,2538 acid+ Caffeine (O) N02BE91 Paracetamol+ Ascorbic acid (O) 36831,3g 3g 0,0250 N02BE92 Paracetamol+ Codeine (O) 597870g 3g 0,4063 N02BE94 Paracetamol+ Codeine+ Caffeine (O) 1366260g 3g 0,9286 N02BE96 Paracetamol+ Ascorbic acid+ Caffeine+ Chlorphenamine (O) 3664g 3g 0,0025

N02BE97 Paracetamol+ Pseudoephedrine+ Dextromethorphan (O) 671416g 3g 0,4563 N02BG Other analgesics and antipyretics 0,0177 N02BG07 (O) 3467g 0,4g 0,0177 N02C ANTIMIGRAINE PREPARATIONS 0,4163 N02CC Selective serotonin (5HT1) agonists 0,4163 N02CC01 Sumatriptan (N) 26,56g 0,02g 0,0027

N02CC01 Sumatriptan (O) 8575,5g 0,05g 0,3497

N02CC02 Naratriptan (O) 5,17g 2,5mg 0,0042

N02CC03 Zolmitriptan (O) 35,835g 2,5mg 0,0292

N02CC04 Rizatriptan (O) 33,3g 0,01g 0,0068

N02CC07 Frovatriptan (O) 28,985g 2,5mg 0,0236 N03 ANTIEPILEPTICS 6,8444 N03A ANTIEPILEPTICS 6,8444 N03AA Barbiturates and derivatives 0,4467 N03AA02 (O) 18565g 0,1g 0,3785 N03AA02 Phenobarbital (P) 63g 0,1g 0,0013 N03AA03 Primidone (O) 41000g 1,25g 0,0669

30/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N03AA80 Benzobarbital (O) 250 g N03AB Hydantoin derivatives 0,0537 N03AB02 (O) 7660g 0,3g 0,0521 N03AB02 Phenytoin (P) 243,75g 0,3g 0,0017 N03AD Succinimide derivatives 0,0077 N03AD01 Ethosuximide (O) 4750g 1,25g 0,0077 N03AE derivatives 0,7426 N03AE01 Clonazepam (O) 2913,6g 0,008g 0,7426 N03AF Carboxamide derivatives 2,9794 N03AF01 (O) 1050669g 1g 2,1423 N03AF02 Oxcarbazepine (O) 410565g 1g 0,8371 N03AG Fatty acid derivatives 1,2692 N03AG01 Valproic acid (O) 928990g 1,5g 1,2628 N03AG01 Valproic acid (P) 334,3g 1,5g 0,0005 N03AG04 Vigabatrin (O) 5800g 2g 0,0059 N03AX Other antiepileptics 1,3450 N03AX03 Sultiame (O) 110g 0,4g 0,0006 N03AX09 Lamotrigine (O) 52988,04g 0,3g 0,3601 N03AX11 (O) 27102g 0,3g 0,1842 N03AX12 (O) 322782g 1,8g 0,3656 N03AX14 Levetiracetam (O) 119145g 1,5g 0,1620 N03AX16 (O) 40079,55g 0,3g 0,2724 N03AX17 (O) 30g 1g 0,0001 N03AX18 Lacosamide (O) 8,4g 0,3g 0,0001 N03AX21 (O) 478,8 g N03AX22 perampanel (O) 9,408 g N04 ANTI-PARKINSON DRUGS 3,8048 N04A ANTICHOLINERGIC AGENTS 0,5948 N04AA Tertiary amines 0,5948 N04AA01 Trihexyphenidyl (O) 2917g 0,01g 0,5948 N04B DOPAMINERGIC AGENTS 3,2101 N04BA Dopa and dopa derivatives 1,3353 N04BA03 Levodopa + Carbidopa+ Entacapone (O) 56610g 0,45g 0,2565 N04BA80 Levodopa + Benserazide (O) 227140g 0,6g 0,7719 N04BA81 Levodopa + Carbidopa (O) 90302g 0,6g 0,3069 N04BB Adamantane derivatives 0,3632 N04BB01 Amantadine (O) 35622g 0,2g 0,3632 N04BB01 Amantadine (P) 66 g N04BC Dopamine agonists 0,8429 N04BC04 Ropinirole (O) 1295,763g 0,006g 0,4403 N04BC05 Pramipexole (O) 492,935g 2,5mg 0,4020 N04BC07 Apomorphine (P) 4,8g 20mg 0,0005 N04BD Monoamine oxidase type B inhibitors 0,6687 N04BD01 Selegiline (O) 2g 0,005g 0,0008 N04BD02 Rasagiline (O) 327,572g 0,001g 0,6679 N04BX Other dopaminergic agents <0,0001 N04BX01 Tolcapone (O) 10g 0,45g <0,0001 N05 PSYCHOLEPTICS 38,0679 N05A ANTIPSYCHOTICS 6,9276 N05AA Phenothiazines with aliphatic side-chain 0,2013 N05AA01 Chlorpromazine (O) 17805g 0,3g 0,1210 N05AA01 Chlorpromazine (P) 110g 0,1g 0,0022 N05AA02 Levomepromazine (O) 11364,25g 0,3g 0,0772 N05AA02 Levomepromazine (P) 25g 0,1g 0,0005 N05AA02 Levomepromazine (P, V) 12,5g 0,1g 0,0003 N05AB Phenothiazines with piperazine structure 0,0713 N05AB02 Fluphenazine (P) 7,05g 0,001g 0,0144 N05AB03 Perphenazine (O) 432,8g 0,03g 0,0294

31/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05AB03 Perphenazine (P) 135g 0,01g 0,0275 N05AC Phenothiazines with piperidine structure 0,0008 N05AC01 Periciazine (O) 18g 0,05g 0,0007 N05AC02 Thioridazine (O) 15g 0,3g 0,0001 N05AD Butyrophenone derivatives 1,1549 N05AD01 Haloperidol (O) 2320,84g 0,008g 0,5915 N05AD01 Haloperidol (P) 797,1g 0,008g 0,2032 N05AD03 Melperone (O) 52997,5g 0,3g 0,3602 N05AE Indole derivatives 0,1678 N05AE03 Sertindole (O) 1005,744g 0,016g 0,1282 N05AE04 Ziprasidone (O) 1552,32g 0,08g 0,0396 N05AE04 Ziprasidone (P) 2g 0,04g 0,0001 N05AF Thioxanthene derivatives 0,7431 N05AF01 (O) 403,85g 0,006g 0,1372 N05AF01 Flupentixol (P) 69,18g 0,004g 0,0353 N05AF03 Chlorprothixene (O) 39940g 0,3g 0,2715 N05AF05 Zuclopenthixol (O) 1421,5g 0,03g 0,0966 N05AF05 Zuclopenthixol (P) 2979,7g 0,03g 0,2025 N05AG Diphenylbutylpiperidine derivatives 0,0008 N05AG02 Pimozide (O) 1,545g 0,004g 0,0008 N05AH Diazepines, oxazepines and thiazepines 3,4138 N05AH02 Clozapine (O) 79413,75g 0,3g 0,5397 N05AH03 Olanzapine (O) 6128,78g 0,01g 1,2496 N05AH03 Olanzapine (P) 13,2g 0,01g 0,0027 N05AH04 Quetiapine (O) 318135,75g 0,4g 1,6217 N05AL Benzamides 0,1008 N05AL01 Sulpiride (O) 19708,5g 0,8g 0,0502 N05AL05 Amisulpride (O) 9912g 0,4g 0,0505 N05AN Lithium 0,1665 N05AN01 Lithium (O) 73500g 0,9g 0,1665 N05AX Other antipsychotics 0,9065 N05AX08 Risperidone (O) 1236,86g 0,005g 0,5044 N05AX08 Risperidone (P) 58,475g 2,7mg 0,0442 N05AX12 Aripiprazole (O) 2627,1g 0,015g 0,3571 N05AX12 Aripiprazole (P) 6,4935g 0,015g 0,0009 N05B 13,8489 N05BA Benzodiazepine derivatives 13,8480 N05BA01 (O) 30240,65g 0,01g 6,1660 N05BA01 Diazepam (P) 1302,9g 0,01g 0,2657 N05BA01 Diazepam (R) 55,975g 0,01g 0,0114 N05BA02 (O) 5,5g 0,03g 0,0004 N05BA04 (O) 1132,56g 0,05g 0,0462 N05BA06 (P) 6,6 g N05BA08 (O) 6992,235g 0,01g 1,4257 N05BA09 (O) 21,1g 0,02g 0,0022 N05BA12 (O) 2890,3525g 0,001g 5,8934 N05BA80 (O) 18,175g 0,001g 0,0371 N05BB Diphenylmethane derivatives 0,0009 N05BB01 (O) 33,45g 0,075g 0,0009 N05C HYPNOTICS AND SEDATIVES 17,2914 N05CD Benzodiazepine derivatives 1,4458 N05CD02 Nitrazepam (O) 2536,4g 0,005g 1,0343

N05CD05 Triazolam (O) 5,6475g 0,25mg 0,0461

N05CD08 Midazolam (O) 1625,1599g 0,015g 0,2209

32/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05CD08 Midazolam (P) 1063,2844g 0,015g 0,1445 N05CF Benzodiazepine related drugs 15,7607 N05CF01 (O) 48152,775g 7,5mg 13,0910 N05CF02 (O) 13092,95g 0,01g 2,6696 N05CH Melatonin receptor agonists 0,0849 N05CH01 Melatonin (O) 83,286g 2mg 0,0849 N05CM Other hypnotics and sedatives N05CM18 (P) 0,0838 g

N05CM82 Phenobarbital+ herbal preparation+ Peppermint oil (O) 275ml N06 PSYCHOANALEPTICS 25,5105 N06A ANTIDEPRESSANTS 19,9111 N06AA Non-selective monoamine reuptake inhibitors 2,0630 N06AA02 Imipramine (O) 130g 0,1g 0,0027 N06AA04 (O) 3455,85g 0,1g 0,0705 N06AA04 Clomipramine (P, V) 3g 0,1g 0,0001 N06AA09 (O) 55266,5g 0,075g 1,5025 N06AA10 Nortriptyline (O) 17912,5g 0,075g 0,4870 N06AA21 Maprotiline (O) 17,5g 0,1g 0,0004 N06AB Selective serotonin reuptake inhibitors 12,7885 N06AB03 (O) 25008,28g 0,02g 2,5496 N06AB04 (O) 16316,42g 0,02g 1,6634 N06AB05 (O) 18323,4g 0,02g 1,8681 N06AB06 (O) 49740,3g 0,05g 2,0284 N06AB08 (O) 224,5g 0,1g 0,0046 N06AB10 (O) 22925,54g 0,01g 4,6745 N06AF Monoamine oxidase inhibitors, non-selective 0,0030 N06AF04 Tranylcypromine (O) 14,56g 0,01g 0,0030 N06AG Monoamine oxidase type A inhibitors 0,0005 N06AG02 Moclobemide (O) 75g 0,3g 0,0005 N06AX Other antidepressants 5,0561 N06AX03 Mianserin (O) 23,1g 0,06g 0,0008 N06AX11 (O) 22290,75g 0,03g 1,5150 N06AX12 Bupropione (O) 30969g 0,3g 0,2105 N06AX14 (O) 16631,25g 0,0375g 0,9043 N06AX16 (O) 79383,15g 0,1g 1,6186 N06AX17 Milnacipran (O) 1725,5g 0,1g 0,0352 N06AX18 Reboxetine (O) 1,68g 0,008g 0,0004 N06AX21 Duloxetine (O) 20697,6g 0,06g 0,7034 N06AX22 Agomelatine (O) 833g 0,025g 0,0679 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 0,5292 NOOTROPICS N06BA Centrally acting sympathomimetics 0,2732 N06BA04 Methylphenidate (O) 3762,75g 0,03g 0,2557 N06BA07 Modafinil (O) 138g 0,3g 0,0009 N06BA09 Atomoxetine (O) 647,556g 0,08g 0,0165 N06BC Xanthine derivatives 0,0011 N06BC01 Caffeine (O, P) 1,2g 0,4g <0,0001 N06BC80 Coffeini-sodium benzoate (P) 210g 0,4g 0,0011 N06BX Other psychostimulants and nootropics 0,2549 N06BX03 Piracetam (O) 299288,25g 2,4g 0,2543 N06BX03 Piracetam (P) 1908g 6g 0,0006 N06BX18 Vinpocetine (O) 253 g N06BX82 Picamilon (O) 13,5 g N06BX83 Aminobutyric acid (O) 12320 g

33/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N06D ANTI-DEMENTIA DRUGS 5,0702 N06DA Anticholinesterases 0,2242 N06DA02 Donepezil (O) 824,04g 7,5mg 0,2240 N06DA04 Galantamine (O) 1,344g 0,016g 0,0002 N06DX Other anti-dementia drugs 4,8460 N06DX01 Memantine (O) 624,4g 0,02g 0,0637 N06DX02 Ginkgo folium (O) 281454,6g 0,12g 4,7823 N06DX80 cerebrolysine (P) 53,8 g N07 OTHER NERVOUS SYSTEM DRUGS 9,3312 N07A PARASYMPATHOMIMETICS 0,3040 N07AA Anticholinesterases 0,3040 N07AA01 neostigmine (O) 48,6g 0,06g 0,0017 N07AA01 neostigmine (P) 39,335g 0,002g 0,0401 N07AA02 Pyridostigmine bromide (O) 21822g 0,18g 0,2472 N07AA03 Distigmine bromide (O) 8,25g 0,005g 0,0034 N07AA80 neostigmine+ Glycopyrronium bromide (P) 5750ml 1ml 0,0117 N07B DRUGS USED IN ADDICTIVE DISORDERS 2,8188 N07BA Drugs used in nicotine dependence 1,0682 N07BA01 Nicotine (O) 7675,648g 0,03g 0,5217 N07BA01 Nicotine (TD) 3581,816g 0,014g 0,5217 N07BA03 Varenicline (O) 24,3935g 2mg 0,0249 N07BB Drugs used in dependence 0,1848 N07BB01 Disulfiram (O) 17450g 0,2g 0,1779 N07BB01 Disulfiram (P) 333 g N07BB04 (O) 168g 50mg 0,0069 N07BC Drugs used in opioid dependence 1,5659 N07BC02 Methadone (O) 19017g 0,025g 1,5510 N07BC51 Buprenorphine+ (SL) 58,24g 8mg 0,0148 N07C ANTIVERTIGO PREPARATIONS 6,1986 N07CA Antivertigo preparations 6,1986 N07CA01 Betahistine (O) 51150,48g 0,024g 4,3456 N07CA02 Cinnarizine (O) 81790g 0,09g 1,8530 N07X OTHER NERVOUS SYSTEM DRUGS 0,0097 N07XX Other nervous system drugs 0,0097 N07XX02 Riluzole (O) 386,4g 0,1g 0,0079 N07XX06 Tetrabenazine (O) 89,6g 0,1g 0,0018 ANTIPARASITIC PRODUCTS, INSECTICIDES AND P 0,8385 REPELLENTS P01 ANTIPROTOZOALS 0,6856 AGENTS AGAINST AMOEBIASIS AND OTHER P01A PROTOZOAL DISEASES P01AB Nitroimidazole derivatives P01AB01 Metronidazole (O) 8384,4 g P01B ANTIMALARIALS 0,6856 P01BA Aminoquinolines 0,6646 P01BA02 Hydroxychloroquine (O) 168084g 0,516g 0,6642 P01BA03 Primaquine (O) 2,7g 0,015g 0,0004 P01BB Biguanides 0,0140 P01BB51 Proguanil+ Atovaquone (O) 936pieces 16pieces 0,0001 P01BB51 Proguanil+ Atovaquone (O) 27168pieces 4pieces 0,0138 P01BC Methanolquinolines 0,0061 P01BC01 Quinine (P) 49,18g 1,5g 0,0001 P01BC02 Mefloquine (O) 2954g 1g 0,0060 P01BD Diaminopyrimidines 0,0010 P01BD01 Pyrimethamine (O) 33g 0,075g 0,0009 P01BD80 Pyrimethamine+ Sulfadoxine (O) 3,75g 0,075g 0,0001 P02 ANTHELMINTICS 0,1529 P02B ANTITREMATODALS 0,0005

34/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day P02BA derivatives and related substances 0,0005 P02BA01 Praziquantel (O) 702g 3g 0,0005 P02C ANTINEMATODAL AGENTS 0,1524 P02CA Benzimidazole derivatives 0,1524 P02CA01 Mebendazole (O) 14487,6g 0,2g 0,1477 P02CA03 Albendazole (O) 920g 0,4g 0,0047 P02CE Imidazothiazole derivatives <0,0001 P02CE01 Levamisole (O) 0,15g 0,15g <0,0001 ECTOPARASITICIDES, INCL. SCABICIDES, P03 INSECTICIDES AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin (C) 314352 ml P03AC04 Permethrin (C) 369510 g P03AC81 Allethrin+ Piperonyl butoxid (C) 1600 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate (C) 240900 g R RESPIRATORY SYSTEM 70,1944 R01 NASAL PREPARATIONS 29,8790 DECONGESTANTS AND OTHER NASAL PREPARATIONS R01A 27,9180 FOR TOPICAL USE R01AA Sympathomimetics, plain 20,9363 R01AA07 Xylometazoline (N) 8186,62g 0,8mg 20,8655 R01AA08 Naphazoline (N) 13,88g 0,4mg 0,0708 R01AB Sympathomimetics, combinations excl. corticosteroids 0,7393 R01AB83 Xylometazoline+ Ipratropium bromide (N) 290070ml 0,8ml 0,7393 R01AC Antiallergic agents, excl. corticosteroids 0,2447 R01AC03 Azelastine (N) 67,2g 0,56mg 0,2447 R01AD Corticosteroids 5,9978 R01AD01 Beclometasone (N) 41,47g 0,4mg 0,2114 R01AD05 Budesonide (N) 107,3696g 0,2mg 1,0946 R01AD08 Fluticasone (N) 74,25g 0,2mg 0,7570 R01AD09 Mometasone (N) 228,151g 0,2mg 2,3260 R01AD12 Fluticasone furoate (N) 86,7933g 0,11mg 1,6088 R01AX Other nasal preparations R01AX06 Mupirocin (N) 24 g R01AX83 Retinol+ Tocopherol (N) 139700 ml Tocopherol+ Eucalyptus oil+ Pine silvesteris oil+ Thymol+ R01AX87 367930 ml Peppermint oil+ Guaiazulene (N) R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 1,9609 R01BA Sympathomimetics 1,9609 R01BA02 Pseudoephedrine (O) 141563,88g 0,24g 1,2027 R01BA81 Pseudoephedrine+ Triprolidine (O) 9999,6g 0,24g 0,0850 R01BA84 Pseudoephedrine+ Guaifenesin (O) 18646,8g 0,24 g 0,1584 R01BA89 Pseudoephedrine+ Loratadine (O) 14532g 0,24g 0,1235 R01BA93 Pseudoephedrine+ Cetirizine (O) 46072,32g 0,24 g 0,3914 R02 THROAT PREPARATIONS 1,5410 R02A THROAT PREPARATIONS 1,5410 R02AA Antiseptics 1,4814 R02AA06 Cetylpyridinium chloride (O) 332892 pieces R02AA83 Chlorhexidine+ Benzocaine (O) 7152pieces 6pieces 0,0024 R02AA89 Povidone, iodinated+ Allantoin (O) 293430 ml R02AA92 + Cinchocaine (O) 922800pieces 6pieces 0,3136 R02AA94 Amylmetacresol+ Dichlorobenzyl alcohol (O) 449496pieces 6pieces 0,1528 R02AA95 Amylmetacresol+ Dichlorobenzyl alcohol+ Levomenthol (O) 1691664pieces 6pieces 0,5749

35/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R02AA96 Amylmetacresol+ Dichlorobenzyl alcohol+ Ascorbic acid (O) 310632pieces 6pieces 0,1056 R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 520260 ml R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 704964pieces 6pieces 0,2396 Benzalkonium chloride+ Eucalyptus oil+ Levomenthol+ R02AA99 272610pieces 6pieces 0,0926 Peppermint oil+ Thymol (O) R02AB Antibiotics R02AB03 Fusafungine (N, O) 208270 ml R02AD Anesthetics, local R02AD02 Lidocaine (O) 58440 pieces R02AD80 Lidocaine+ Propyl parahydroxybenzoate (O) 650780 pieces R02AX Other throat preparations 0,0595 R02AX01 Flurbiprofen (O) 1284,92g 44mg 0,0595 R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 20,1566 R03A ADRENERGICS, INHALANTS 13,6574 R03AC Selective beta-2-adrenoceptor agonists 5,4628 R03AC02 Salbutamol (I) 982,924g 0,8mg 2,5052 R03AC02 Salbutamol (I) 1196,2g 0,01g 0,2439 R03AC04 Fenoterol (I) 112,38g 0,6mg 0,3819 R03AC12 Salmeterol (I) 16,698g 0,1mg 0,3405 R03AC13 Formoterol (I) 17,1997g 0,024mg 1,4612 R03AC18 Indacaterol (I) 38,9925g 0,15mg 0,5300 R03AK Adrenergics and other drugs for obstructive airway diseases 8,1946 R03AK80 Fenoterol+ Ipratropium bromide (I) 104700ml 16 ml 0,0133 R03AK80 Fenoterol+ Ipratropium bromide (I) 2266600doses 6doses 0,7703 R03AK82 Salmeterol+ Fluticasone (I) 822000doses 4doses 0,4190 R03AK82 Salmeterol+ Fluticasone (I) 3261840doses 2doses 3,3254 R03AK83 Formoterol+ Budesonide (I) 840900doses 2doses 0,8573 R03AK83 Formoterol+ Budesonide (I) 4921080doses 4doses 2,5085 R03AK84 Formoterol+ Beclometasone (I) 590040doses 4doses 0,3008 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 3,5784 INHALANTS R03BA Glucocorticoids 1,8371 R03BA01 Beclometasone (I) 48,55g 0,8mg 0,1237 R03BA02 Budesonide (I) 77,7g 1,5mg 0,1056 R03BA02 Budesonide (I) 484,772g 0,8mg 1,2356 R03BA05 Fluticasone (I) 109,515g 0,6mg 0,3722 R03BB Anticholinergics 1,7413 R03BB01 Ipratropium bromide (I) 22,745g 0,3mg 0,1546 R03BB01 Ipratropium bromide (I) 60,752g 0,12mg 1,0323 R03BB04 Tiotropium bromide (I) 1,3596g 0,005mg 0,5544 R03C ADRENERGICS FOR SYSTEMIC USE 0,2626 R03CC Selective beta-2-adrenoceptor agonists 0,2626 R03CC02 Salbutamol (O) 1540,56g 0,012g 0,2618

R03CC02 Salbutamol (P) 0,73g 0,012g 0,0001

R03CC03 Terbutaline (O) 5,55g 0,015g 0,0008 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,6582 DISEASES R03DA Xanthines 1,6515 R03DA04 Theophylline (O) 314086g 0,4g 1,6010 R03DA05 Aminophylline (O) 54g 0,6g 0,0002 R03DA05 Aminophylline (P) 14805g 0,6g 0,0503 R03DC Leukotriene receptor antagonists 1,0038

36/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R03DC03 Montelukast (O) 4922,82g 0,01g 1,0038 R03DX Other systemic drugs for obstructive airway diseases 0,0029 R03DX05 (P) 22,95g 0,016g 0,0029 R05 COUGH AND COLD PREPARATIONS 7,1233 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 7,0051 SUPPRESSANTS R05CA Expectorants 0,2375 R05CA03 Guaifenesin (O) 104835,4g 0,9g 0,2375 R05CA84 Luuderohu ekstrakt (O) 120300 pieces R05CA84 Luuderohu ekstrakt (O) 8036365 ml R05CA87 Myrtol standardized (O) 1021020 pieces R05CA88 Thyme herb+ nõmm-liivatee+ teeleht (O) 1862900 ml R05CA89 Thyme herb+ Luuderohu ekstrakt (O) 18350ml R05CA91 Thyme herb+ Marshmallow root (O) 849750ml R05CB Mucolytics 6,7676 R05CB01 Acetylcysteine (O) 829950,4g 0,5g 3,3845 R05CB01 Acetylcysteine (P) 13437 g R05CB02 Bromhexine (O) 9820,08g 0,024g 0,8343 R05CB03 Carbocisteine (O) 161345g 1,5g 0,2193 R05CB06 Ambroxol (O) 136320,6g 0,12g 2,3163 R05CB13 Dornase alfa (I) 16,2g 2,5mg 0,0132 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,0902 EXPECTORANTS R05DB Other cough suppressants 0,0902 R05DB09 Oxeladin (O) 3539,75g 0,08g 0,0902 COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,0279 COMBINATIONS R05FA Opium derivatives and expectorants 0,0279 R05FA80 Codeine+ Guaifenesin (O) 410400ml 30ml 0,0279 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+ nurmenukuõis+ hapu oblikas+ Elder flower+ R05XA80 1796400 ml raudürdiürt (O) Gentian root+ nurmenukuõis+ hapu oblikas+ Elder flower+ R05XA80 2237460 pieces raudürdiürt (O) R06 ANTIHISTAMINES FOR SYSTEMIC USE 11,4939 R06A ANTIHISTAMINES FOR SYSTEMIC USE 11,4939 R06AA Aminoalkyl ethers 0,6095 R06AA02 Diphenhydramine (O) 147g 0,2g 0,0015 R06AA02 Diphenhydramine (P) 67,1 g R06AA04 Clemastine (O) 539,32g 0,002g 0,5498 R06AA04 Clemastine (P) 57,05g 0,002g 0,0582 R06AE Piperazine derivatives 5,5397 R06AE07 Cetirizine (O) 25094,325g 0,01g 5,1167 R06AE09 Levocetirizine (O) 1037,18g 0,005g 0,4230 R06AX Other antihistamines for systemic use 5,3448 R06AX13 Loratadine (O) 15608,8g 0,01g 3,1826 R06AX17 Ketotifen (O) 3,87g 0,002g 0,0039 R06AX22 Ebastine (O) 5474g 0,01g 1,1161 R06AX27 Desloratadine (O) 2420,88g 0,005g 0,9872 R06AX28 Rupatadine (O) 269g 0,01g 0,0548 R06AX80 Bilastine (O) 2054,4 g R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0007 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0007 R07AA Lung surfactants 0,0007 R07AA02 Natural phospholipids (endotrach) 51,6g 0,16g 0,0007 S SENSORY ORGANS 24,0016

37/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01 OPHTHALMOLOGICALS 24,0016 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol (S) 153270 ml S01AA12 Tobramycin (S) 32260 ml S01AA12 Tobramycin (S) 44334,5 g S01AA13 Fusidic acid (S) 55950 g S01AB Sulfonamides S01AB01 Sulfamethizole (S) 618980 ml S01AD Antivirals S01AD03 Aciclovir (S) 3969 g S01AX Other antiinfectives S01AX13 Ciprofloxacin (S) 20085 ml S01AX19 Levofloxacin (S) 19440 ml S01AX22 Moxifloxacin (S) 1775 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone (S) 5 pieces S01BA01 Dexamethasone (S) 11662 g S01BA01 Dexamethasone (S) 146165 ml S01BA02 Hydrocortisone (S) 6618 g S01BA14 Loteprednol (S) 5495 ml S01BC Antiinflammatory agents, non-steroids S01BC03 Diclofenac (S) 11120 ml S01BC10 Nepafenac (S) 6410 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+ Neomycin+ Polymyxin B (S) 25025 ml S01CA81 Dexamethasone+ Tobramycin (S) 8627,5 g S01CA81 Dexamethasone+ Tobramycin (S) 35085 ml S01CA82 Dexamethasone+ Chloramphenicol (S) 28465,5g S01CA82 Dexamethasone+ Chloramphenicol (S) 337830ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 24,0016 S01EA Sympathomimetics in glaucoma therapy 0,0006 S01EA05 Brimonidine (S) 55ml 0,2ml 0,0006 S01EB Parasympathomimetics 0,0708 S01EB01 Pilocarpine hydrochloride (S) 1345ml 0,4ml 0,0069 S01EB02 Carbachol (S) 684ml 0,4ml 0,0035 S01EB80 Pilocarpine hydrochloride+ Timolol (S) 5930ml 0,2ml 0,0605 S01EC Carbonic anhydrase inhibitors 1,9268 S01EC01 Acetazolamide (O) 22700g 0,75g 0,0617 S01EC01 Acetazolamide (P) 65g 0,75g 0,0002 S01EC03 Dorzolamide (S) 105840ml 0,3ml 0,7194 S01EC04 Brinzolamide (S) 112370ml 0,2ml 1,1456 S01ED Beta blocking agents 14,7883 S01ED01 Timolol (S) 103955g 40mg 5,2991 S01ED01 Timolol (S) 219630ml 0,2ml 2,2391 S01ED02 Betaxolol (S) 114850ml 0,2ml 1,1709 S01ED80 Timolol+ Dorzolamide (S) 358160ml 0,2ml 3,6514 S01ED81 Timolol+ Travoprost (S) 37070ml 0,2ml 0,3779 S01ED82 Timolol+ Bimatoprost (S) 41124ml 0,2ml 0,4193 S01ED83 Timolol+ Brinzolamide (S) 103400ml 0,2ml 1,0542 S01ED84 Timolol+ Latanoprost (S) 56550ml 0,2ml 0,5765 S01EE Prostaglandin analogues 7,2150 S01EE01 Latanoprost (S) 242055ml 0,1ml 4,9355 S01EE03 Bimatoprost (S) 51ml 0,1ml 0,0010 S01EE04 Travoprost (S) 107235ml 0,1ml 2,1865

38/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01EE05 Tafluprost (S) 13536ml 0,3ml 0,0920 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine (S) 540 ml S01FA04 Cyclopentolate (S) 28755 ml S01FA06 Tropicamide (S) 13950 ml S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine (S) 4400 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline (S) 348045 ml S01GX Other antiallergics S01GX01 Cromoglicic acid (S) 97715 ml S01GX07 Azelastine (S) 19074 ml S01GX09 Olopatadine (S) 11085 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 Tetracaine (S) 5520 ml S01HA04 Proxymetacaine (S) 46095 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein (P) 6860 ml S01JA01 Fluorescein (S) 2200 ml S01JA81 Fluorescein+ Oxybuprocaine+ Chlorobutanol (S) 885ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose (S) 5370 g S01KA80 Hypromellose+ Dextran (S) 552180 ml S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA03 Pegaptanib (S) 4 pieces S01LA04 Ranibizumab (S) 47 pieces S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride (S) 70 g S01XA80 Retinol+ Dexpanthenol (S) 6909 g S01XA81 Carbomer (S) 191830 g S01XA82 Hypromellose (S) 168470 ml S02 OTOLOGICALS S02B CORTICOSTEROIDS S02BA Corticosteroids S02BA07 Betamethasone (A, S) 50 ml CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+ Neomycin+ Acetic acid, glacial (A) 105ml S02CA82 Hydrocortisone+ Ciprofloxacin (A) 119270 ml S02CA83 Hydrocortisone+ Gentamicin (A) 100 ml S02CA84 Hydrocortisone+ Polymyxin B+ Neomycin (A) 200 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products T01RS01 herbal preparation (C) 700 g T01RS01 herbal preparation (O) 522190 pieces T01RS01 herbal preparation (O) 21301280 ml T01RS02 homeopathic preparations (A) 30 ml T01RS02 homeopathic preparations (C) 475500 g

39/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day T01RS02 homeopathic preparations (N) 1420 ml T01RS02 homeopathic preparations (O) 370 g T01RS02 homeopathic preparations (O) 1586420 pieces T01RS02 homeopathic preparations (O) 2330510 ml T01RS02 homeopathic preparations (P) 668 ml T01RS02 homeopathic preparations (R) 528 pieces T01RS02 homeopathic preparations (S) 20,25 ml V VARIOUS 0,1159 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen (P) 102 pieces V01AA05 Tree pollen (P) 134 pieces V01AA05 Tree pollen (SL) 6336 ml V01AA07 Allergen products (insects) (P) 24 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,1159 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,1159 V03AB Antidotes V03AB03 Edetates (P) 1,8 g V03AB04 Pralidoxime (O, P) 50 g V03AB14 Protamine sulfate (P) 300 g V03AB15 Naloxone (P) 1,8 g V03AB16 (P) 11400 ml V03AB17 Methylthioninium chloride (P) 135 g V03AB19 Physostigmine (P) 0,05 g V03AB25 (P) 0,1225 g V03AB33 Hydroxocobalamin (P) 120 g V03AB34 Fomepizole (P) 11 g V03AB35 Sugammadex (P) 12 g V03AC Iron chelating agents V03AC01 Deferoxamine (P) 15 g V03AC03 Deferasirox (O) 3129 g V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 0,0554 V03AE01 Polystyrene sulfonate (O, R) 675688g 45g 0,0306 V03AE02 Sevelamer (O) 18144g 6,4g 0,0058 V03AE03 Lanthan (O) 20992,5g 2,25g 0,0190 V03AF Detoxifying agents for antineoplastic treatment 0,0605 V03AF01 Mesna (P) 5316 g V03AF03 Calcium folinate (O) 807g 0,06g 0,0274 V03AF03 Calcium folinate (P) 444,05g 0,06g 0,0151 V03AF07 Rasburicase (P) 0,1688g 0,014g <0,0001 V03AF10 Sodium levofolinate (P) 264,25g 0,03g 0,0180 V03AH Drugs for treatment of hypoglycemia V03AH01 Diazoxide (O) 110 g V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD04 Corticorelin (P) 0,0008 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin (P) 3000 U V04CG Tests for gastric secretion V04CG04 Pentagastrin (P) 0,0075 g V04CJ Tests for thyreoidea function V04CJ02 Protirelin (P) 0,0012 g V04CX Other diagnostic agents V04CX80 Patent blue V (P) 50 pieces V04CX81 Methacholine chloride (I) 50,04 g

40/41 Estonian Statistics on Medicines 2012

DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V04CX82 Hexaminolevulinate (P) 24,055 g V04CX83 Indocyanine green (P) 1 g V04CX85 Edrophonium chloride (P) 0,2 g V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride (P) 4939400 ml V07AB83 Water for injection (NA) 6041100 ml V07AY Other non-therapeutic auxiliary products V07AY80 doonororgani säilituslahus (NA) 33600 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, high osmolar X-ray contrast V08AA media V08AA01 Sodium amidotrizoate+ Meglumine Amidotrizoate (P) 8000ml Watersoluble, nephrotropic, low osmolar X-ray contrast V08AB media V08AB02 (P) 770052 g V08AB04 (P) 520170,95 g V08AB05 (P) 880838,5 g V08AB09 (P) 2487805 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids (P) 48 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA containing X-ray contrast media V08BA01 Barium sulfate (O) 702320 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 (P) 2400 ml V08CA03 (P) 65150 ml V08CA06 Gadoversetamide (P) 1050 ml V08CA09 (P) 25300 ml V08CA10 (P) 1800 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulphur hexafluoride (P) 125 ml

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