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Medicines & in 1 2009 Development for •

his table is adapted from the latest Pharmaceutical Research , 52 for myeloma, 63 for , 54 for pan- Tand Manufacturers of America survey of cancer-related creatic cancer, 27 for sarcoma, 67 for skin cancer, 203 for vari- medicines and vaccines. Of the 861 medicines in develop- ous solid tumors, 27 for , 51 for cancer-related ment—all in either clinical trials or under FDA review—122 conditions, and 129 for other and unspecified (Some are for , 106 for , 103 for prostate can- of the products target more than one type of cancer.) cer, 70 for , 23 for bladder cancer, 61 for brain The chart shows the name of each product, the sponsor, cancer, 13 for cervical cancer, 14 for , 44 the indication, the development status as of the time of the re-

for kidney cancer, 129 for , 35 for , 99 for port at the end of March, and a contact telephone number. oncology-times.com

Development Development Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Bladder Cancer polyphenon E Polyphenon Pharma superficial bladder Phase II New York, NY cancer (212) 661-0578 Advexin® Introgen Therapeutics (see also brain, breast, Phase I (see also leukemia, contusugene Austin, TX head/neck, lung, (512) 708-9310 prostate) ladenovec ovarian, prostate, stomach) Allos Therapeutics (see also lung, Phase II (PDX) Westminster, CO ) (303) 426-6262 BC-819 BioCancell Phase II Therapeutics SCH-58500 Schering-Plough (see also head/ Phase I Jerusalem, Israel (p53 gene Kenilworth, NJ neck, liver, lung, (908) 298-4000 Topo Target USA combination Phase II therapy) cancer-related) Rockaway, NJ (see also colorectal, (973) 895-6900 SCH-721015 Schering-Plough Phase I leukemia, liver, Kenilworth, NJ (908) 298-4000 lung, lymphoma, Tarceva® neoadjuvant therapy Phase II ovarian) South San Francisco, (see also brain, breast, (650) 224-1000 CDX-1307 Celldex Therapeutics (see also breast, Phase I CA colorectal, head/neck, (800) 572-1932 Needham, MA colorectal, ovarian, (781) 433-0771 pancreatic) OSI Pharmaceuticals liver, lung, other) Melville, NY Celebrex® (see also prostate) Phase III New York, NY (860) 732-5156 Valstar® Indevus Pharmaceuticals application Lexington, MA submitted CG0070 Genesys Phase I South San Francisco (650) 266-3000 (781) 861-8444 (888) 669-6682 VB-4845 Viventia Biotech (see also head/neck) Phase II Pharmaceuticals Mississauga, Canada (905) 361-8686 East Hanover, Pierre Fabre (see also breast) Phase II NJ Pharmaceuticals (973) 898-1042 Chemophase™ Halozyme superficial bladder Phase I/II Parsippany, NJ hyaluronidase Therapeutics cancer (858) 794-8889 San Diego, CA Brain Cancer EOquin® Spectrum Phase III apaziquone Pharmaceuticals (949) 788-6700 mAb United Therapeutics neuroblastoma, Phase II Irvine, CA Silver Spring, MD leptomeningeal cancer (301) 608-9292 Erbitux® Bristol-Myers Squibb (see also colorectal, Phase II (see also other) Princeton, NJ head/neck, lung, (212) 546-4000 8H9 mAb United Therapeutics Phase I Eli Lilly prostate, stomach) (800) 545-5979 Silver Spring, MD (301) 608-9292 Indianapolis, IN (212) 645-1405 ® ImClone Systems Advexin Introgen Therapeutics Phase I New York, NY contusugene Austin, TX (see also bladder, (512) 708-9310 Hexvix® GE Healthcare diagnostic imaging of application ladenovec breast, head/neck, lung, hexyl Waukesha, WI bladder cancer submitted ovarian, prostate, aminolevulinate stomach) Iressa® AstraZeneca (see also brain) Phase II AEE788 Novartis glioblastoma multiforme Phase I gefitinib Wilmington, DE (800) 236-9933 Pharmaceuticals (see also solid tumors) (888) 669-6682 sanofi-aventis (see also pancreatic) Phase III East Hanover, NJ (XRP9881) Bridgewater, NJ (800) 633-1810 AMG 102 glioma Phase II Levulan® PD DUSA (see also cervical, Phase I/II Thousand Oaks, CA (see also colorectal, (805) 447-1000 aminolevulinic Pharmaceuticals colorectal, lung, (978) 657-7500 kidney, lung, stomach) acid Wilmington, MAstomach) ANG-1005 AngioChem metastatic brain cancer, Phase I MCC/HA Bioniche Life second-line therapy Phase III Montreal, Canada metastatic (514) 788-7800 Sciences Belleville, (800) 265-5464 glioblastoma Canada Armala™ GlaxoSmithKline glioma Phase II OGX-427 Oncogenex (see also breast, lung, Phase I pazopanib Rsch. Triangle (see also breast, cervical, (888) 825-5249 Pharmaceuticals ovarian, prostate) (425) 686-1500 Park, NC kidney, liver, lung, Bothell, WA ovarian, sarcoma, other)

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2 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Brain Cancer gimatecan Novartis glioma Phase I/II (Orphan Drug) Pharmaceuticals (see also leukemia) (888) 669-6682 Avastin® Genentech glioblastoma application East Hanover, NJ South San Francisco, (see also colorectal, submitted GliAtak™ Advantagene Phase I/II CA head/neck, kidney, (650) 225-1000 gene therapy Boston, MA (617) 916-5445 liver, lung, lymphoma, San Diego, CA (760) 943-8981 , ovarian, pancreatic, ICT-107 ImmunoCellular glioblastoma Phase I prostate, stomach, (cancer ) Therapeutics (818) 992-2907 Woodland Hills, CA oncology-times.com other) ® metastatic brain Phase II Iressa AstraZeneca glioblastoma Phase II cancer from (650) 225-1000 gefitinib Wilmington, DE (see also bladder) (800) 236-9933 NSCLC Karenitecin® BioNumerik (see also lung, ovarian, Phase II Azedra™ Molecular Insight neuroblastoma in Phase II cositecan Pharmaceuticals skin) completed iodine-labeled Pharmaceuticals children (see also other) (617) 492-5554 San Antonio, TX (210) 614-1701 metaiodobenzyl- Cambridge, MA KRX-0402 Keryx brain cancer, Phase II guanidine glioblastoma (212) 531-5965 Azixa™ Myriad glioblastoma, metastatic Phase II New York, NY (combination therapy), (MPC-6827) Pharmaceuticals brain cancer (801) 584-3600 glioma (combination Salt Lake City, UT (see also skin) therapy) (see also colorectal, kidney, banoxantrone Transcept glioblastoma Phase I/II multiple myeloma, Pharmaceuticals (510) 215-3500 sarcoma) Pt. Richmond, CA laromustine glioma (combination Phase II berubicin Reata Pharmaceuticals brain metastases, Phase II (VNP 40101M) New Haven, CT therapy) (see also (203) 498-4210 (Orphan Drug) Dallas, TX recurrent primary (972) 865-2200 leukemia) brain cancer Lucanix® NovaRx glioma Phase I glioma Phase I belagen- San Diego, CA (see also lung) (858) 552-8600 (972) 865-2200 pumatucel-L BIBW 2992 Boehringer Ingelheim glioblastoma Phase I/II Spectrum glioma (combination Phase I Pharmaceuticals (see also breast, (800) 243-0127 Pharmaceuticals therapy) (949) 788-6700 Ridgefield, CT head/neck, lung) Irvine, CA BMS-844203 Bristol-Myers Squibb glioblastoma Phase II MLN8237 Millennium neuroblastoma Phase I/II (VEGF inhibitor- Princeton, NJ (see also solid tumors) (212) 546-4000 Pharmaceuticals (see also leukemia, (800) 390-5663 adnectin) Cambridge, MA lymphoma, solid BSI-201 BiPar Sciences glioblastoma Phase I/II tumors) Brisbane, CA (see also breast, (650) 635-6050 Neuradiab™ Bradmer glioblastoma Phase III ovarian, other) anti-tenascin Pharmaceuticals (502) 657-6038 CC-8490 Celgene glioblastoma Phase II mAb 81C6-I-131 Louisville, KY Summit, NJ (908) 673-9000 (Orphan Drug) CDX-110 Celldex Therapeutics newly diagnosed Phase II/III OncoGel® Protherics glioblastoma Phase I/II (Orphan Drug) Needham, MA glioblastoma (781) 433-0771 Brentwood, TN (see also pancreatic, (615) 327-1027 Pfizer (see also solid tumors) (860) 732-5156 stomach) New York, NY Oncophage® Antigenics glioma Phase II cilengitide EMD Serono newly diagnosed and Phase II vitespan New York, NY (see also colorectal, (866) 805-8994 (Orphan Drug) Rockland, MA recurrent glioblastoma (800) 283-8088 kidney, pancreatic, (see also lymphoma, skin, stomach) prostate, solid tumors) Novartis glioma Phase I/II cintredekin NeoPharm glioblastoma Phase III Pharmaceuticals (see also breast, (888) 669-6682 besudotox Lake Bluff, IL (847) 887-0800 East Hanover, NJ leukemia, lymphoma, Cotara™ Peregrine glioblastoma Phase I prostate) mAb TNT-1 Pharmaceuticals (714) 508-6000 patupilone Novartis (see also breast, Phase II (Orphan Drug) Tustin, CA (EPO906) Pharmaceuticals colorectal, liver, (888) 669-6682 DCVax®-Brain® Northwest glioblastoma Phase II East Hanover, NJ lung, ovarian) brain cancer Biotherapeutics (425) 608-3000 perifosine AEterna Zentaris glioma Phase II vaccine Bothell, WA Montreal, Canada (see also head/neck, (212) 531-5965 (Orphan Drug) Keryx kidney, lymphoma, EMD 273063 EMD Serono neuroblastoma Phase II Biopharmaceuticals multiple myeloma, Rockland, MA (see also skin) (800) 283-8088 New York, NY ovarian, sarcoma) enzastaurin Eli Lilly glioblastoma Phase II PRX-321 Protox Therapeutics glioblastoma Phase II (LY317615) Indianapolis, IN (combination therapy) (800) 545-5979 (Orphan Drug) Vancouver, Canada (see also solid tumors) (604) 688-0199 (see also breast, colorectal, Reolysin® Oncolytics Biotech glioma Phase I/II lymphoma, multiple reovirus Calgary, Canada (see also head/neck, (403) 670-7377 myeloma, ovarian, prostate) lung, sarcoma, skin) G 207 MediGene glioma Phase I sagopilone Bayer HealthCare (see also breast, ovarian, Phase II (Orphan Drug) San Diego, CA (858) 586-2240 Pharmaceuticals prostate) (888) 842-2937 Wayne, NJ LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 3

3 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

SBG Biotec Pharmacon neuroblastoma Phase I/II Breast Cancer Tromso, Norway (pediatric) www.biotec.no (Combination therapy) ABI-008 Abraxis BioScience metastatic breast cancer Phase I/II Los Angeles, CA (see also prostate) (310) 883-1300 systemic Genentech (see also colorectal, Phase I hedgehog South San Francisco, ovarian, skin) (650) 224-1000 ABT-751 (see also colorectal, Phase II antagonist CA Abbott Park, IL kidney, lung) (847) 937-6100 talampanel Teva Pharmaceuticals newly diagnosed Phase II ABT-869 Abbott Laboratories combination therapy Phase II North Wales, PA glioblastoma (215) 591-3000 Abbott Park, IL (see also kidney, (847) 937-6100 Genentech liver, lung) (650) 225-1000

tandutinib Millennium glioma Phase II oncology-times.com South San Francisco, CA (MLN0518) Pharmaceuticals (see also prostate) (800) 390-5663 Cambridge, MA aderbasib Incyte combination therapy Phase II (INCB7839) Wilmington, DE (302) 498-6700 gliobastoma Phase I/II ® (800) 390-5663 Advexin Introgen Therapeutics combination therapy Phase II contusugene Austin, TX (see also bladder, brain, (512) 708-9310 Tarceva® Genentech glioblastoma Phase II ladenovec head/neck, lung, ovarian, erlotinib South San Francisco, (see also bladder, breast, (650) 225-1000 prostate, stomach) (Orphan Drug) CA colorectal, (800) 572-1932 OSI Pharmaceuticals head/neck, liver, lung, AE-37 Express (see also ovarian) Phase II Melville, NY other) Worcester, MA (508) 852-8783 terameprocol Erimos glioma Phase I/II AG-14699 Pfizer New York, NY (see also ovarian) Phase II Pharmaceuticals (see also cervical, (713) 541-2000 (860) 732-5156 Houston, TX head/neck) Alimta® Eli Lilly (see also head/neck, Phase II TheraCIM™ YM Biosciences glioma (pediatric) Phase II Indianapolis, IN lung, ovarian) (800) 545-5979 Wayne, PA (see also breast, prostate, (610) 560-0600 AMG 386 Amgen (see also kidney, ovarian, Phase II (Orphan Drug) stomach) Thousand Oaks, CA stomach, other) (805) 447-1000 TM-601 TransMolecular recurrent high-grade Phase I AMG 479 Amgen (see also colorectal, lung, Phase II (Orphan Drug) Cambridge, MA glioma (617) 995-3050 Thousand Oaks, CA pancreatic, sarcoma) (805) 447-1000 TM-601-I-131 TransMolecular glioma (intracranial) Phase II Amplimexon® AmpliMed (see also lung, multiple Phase I (Orphan Drug) Cambridge, MA (see also skin) (617) 995-3050 imexon Tucson, AZ myeloma, pancreatic, (520) 529-1000 glioma (intravenous) Phase I/II prostate, skin) (617) 995-3050 anti-CD3 TransTarget metastatic breast cancer Phase I Trisenox® glioma Phase I activated T-cells Hillsborough, CA Frazer, PA (see also leukemia, (610) 344-0200 anti-MUC1 mAb Paladin Labs (see also multiple Phase I multiple myeloma) St. Laurent, Canada myeloma, pancreatic) completed Tykerb® GlaxoSmithKline brain metastases from Phase III (888) 376-7830 lapatinib Rsch. Triangle Park, breast cancer (see also (888) 825-5249 anti-PEM mAb Access Pharmaceuticals Phase I/II NC head/neck, stomach) Dallas, TX (214) 905-5100 VP101 Access Pharmaceuticals glioblastoma Phase II Armala™ GlaxoSmithKline Rsch. combination therapy Phase III (Orphan Drug) Dallas, TX (see also colorectal, (214) 905-5100 pazopanib Triangle Park, NC (see also brain, cervical, (888) 825-5249 leukemia, prostate) kidney, liver, lung, Xcytrin® Pharmacyclics brain metastases from application ovarian, sarcoma, other) motexafin Sunnyvale, CA non-small-cell submitted Aromasin® Pfizer breast cancer prevention Phase III gadolinium lung cancer (408) 774-0330 exemestane New York, NY (860) 732-5156 (see also kidney, ARRY-543 Array BioPharma combination therapy Phase I/II leukemia, lung, lymphoma) Boulder, CO (303) 381-6600 glioma (combination Phase II arzoxifene Eli Lilly invasive breast cancer Phase III therapy) (408) 774-0330 Indianapolis, IN risk reduction (800) 545-5979 glioblastoma Phase I AS-1402 Antisoma Phase II (combination therapy) (408) 774-0330 Cambridge, MA (617) 225-0522 Xerecept® Celtic Pharma peritumoral brain Phase III AVE1642 sanofi-aventis hormonal-sensitive Phase II corticorelin Hamilton, Bermuda edema (441) 299-7440 (anti-IGF-1R Bridgewater, NJ breast cancer (800) 633-1810 (Orphan Drug) mAb) XL-184 Bristol-Myers Squibb glioblastoma in clinical trials AZD2281 AstraZeneca monotherapy Phase II Princeton, NJ (see also other) (212) 546-4000 Wilmington, DE (see also ovarian) (800) 236-9933 Exelixis combination therapy Phase I/II South San Francisco, CA (800) 236-9933 XL-765 Exelixis glioma Phase I AZD4992 AstraZeneca Phase I South San Francisco, (see also solid tumors) (650) 837-7000 Wilmington, DE (800) 236-9933 CA BIBW 2992 Boehringer Ingelheim second-line therapy Phase II Zactima® AstraZeneca glioma (see also breast, Phase I Pharmaceuticals (see also brain, (800) 243-0127 vandetanib Wilmington, DE lung, other) (800) 236-9933 Ridgefield, CT head/neck, lung) Zolinza® Merck glioblastoma Phase II Inovio Biomedical (see also head/neck) Phase I Whitehouse Station, (see also breast, (800) 672-6372 (electrical pulse San Diego, CA (858) 597-6006 NJ colorectal, kidney, delivery) leukemia, lung, bosutinib Pharmaceuticals (see also leukemia, Phase II lymphoma, multiple Collegeville, PA solid tumors) (800) 934-5556 myeloma)

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4 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

breast cancer Quantum Immunologics Phase I/II Hycamtin® GlaxoSmithKline (see also colorectal, Phase II vaccine Tampa, FL (866) 213-4594 Rsch. Triangle Park, head/neck, kidney, (888) 825-5249 BSI-201 BiPar Sciences (see also brain, ovarian, Phase II NC leukemia, lung, Brisbane, CA other) (650) 635-6050 lymphoma, multiple myeloma, ovarian, BTSCAN Molecular Targeting diagnosis of breast cancer Phase I pancreatic, prostate, Technologies (610) 738-7938 stomach, other) West Chester, PA IMC-1121B Eli Lilly (see also colorectal, Phase III BZL-101 Bionovo Phase II Indianapolis, IN kidney, liver, lung, (800) 545-5979 oncology-times.com Emeryville, CA (510) 601-2000 ImClone Systems ovarian, prostate, skin) (212) 645-1405 MabVax Therapeutics (see also sarcoma) Phase I New York, NY San Diego, CA (858) 259-9405 IMC-A12 Eli Lilly (see also colorectal, Phase II Capoxigem® Tragara Pharmaceuticals combination therapy Phase II Indianapolis, IN head/neck, liver, lung, (800) 545-5979 apricoxib San Diego, CA (see also lung, pancreatic) (858) 350-6900 ImClone Systems pancreatic, prostate, (212) 645-1045 CDX-1307 Celldex Therapeutics (see also bladder, Phase I New York, NY sarcoma, solid tumors) Needham, MA colorectal, ovarian, (781) 433-0771 IMT-1012 ImmunoVaccine (see also ovarian) Phase I pancreatic) Technologies (902) 492-1819 Halifax, Canada cediranib AstraZeneca (see also kidney, Phase II Wilmington, DE leukemia) (800) 236-9933 INGN 225 Introgen Therapeutics (see also lung) Phase I/II (p53 vaccine) Austin, TX (512) 708-9310 CNF-2024 Idec (see also leukemia, Phase I Cambridge, MA solid tumors, stomach) (617) 679-2000 ispinesib CytoKinetics (see also colorectal, Phase II South San Francisco, kidney, leukemia) (650) 624-3000 CP-751871 Pfizer combination therapy Phase II CA New York, NY (see also colorectal, lung, (860) 732-5156 multiple myeloma, Ixempra™ Bristol-Myers Squibb early breast cancer in clinical trials prostate, sarcoma) Princeton, NJ (see also lung, (212) 546-4000 pancreatic, prostate) CR011- CurGen (see also skin) Phase II lapuleucel-T Dendreon (see also colorectal, Phase I vcMMAE Branford, CT (888) 436-6642 Seattle, WA ovarian) completed deforolimus ARIAD Pharmaceuticals combination therapy Phase II (206) 256-4545 (MK-8669) Cambridge, MA (see also lung, prostate, (617) 494-0400 LEP-ETU NeoPharm Phase II Merck sarcoma, other) (800) 672-6372 Lake Bluff, IL (847) 887-0800 Whitehouse Station, NJ LOR-2040 Lorus Therapeutics metastatic breast cancer Phase II Doxil® Ortho Biotech combination therapy application Toronto, Canada (see also colorectal, (416) 798-1200 Bridgewater, NJ submitted kidney, leukemia) (908) 541-4000 injection Lymphoseek™ Neoprobe diagnosis of breast Phase III Dublin, OH cancer (see also skin) (800) 793-0079 doxorubicin Sopherion Therapeutics combination therapy Phase III liposomal Princeton, NJ (609) 986-2021 milataxel Taxolog (see also colorectal, lung) Phase II Fairfield, NJ (877) 829-6564 enzastaurin Eli Lilly combination therapy Phase II (LY317615) Indianapolis, IN (see also brain, (800) 545-5979 MK-0646 Merck (see also lung, pancreatic, Phase I colorectal, lymphoma, Whitehouse Station, other) (800) 672-6372 multiple myeloma, NJ ovarian, prostate) MK-0752 Merck (see also leukemia) Phase I mesylate Eisai metastatic breast cancer Phase III Whitehouse Station, NJ (800) 672-6372 (E7389) Woodcliff Lake, NJ (see also head/neck, (888) 422-4743 MKC 1 EntreMed metastatic breast cancer Phase II lung, ovarian, Rockville, MD (see also leukemia, lung, completed prostate, sarcoma, pancreatic) (240) 864-2600 solid tumors) motesanib Amgen combination therapy Phase II advanced breast cancer Phase II Thousand Oaks, CA (see also colorectal, (805) 447-1000 (888) 422-4743 Millennium lung, other) (800) 390-5663 Genasense® (see also leukemia, lung, Phase II Pharmaceuticals Berkeley Heights, NJ lymphoma, skin, completed Cambridge, MA solid tumors) (908) 286-9800 NBI-42902 Neurocrine Biosciences (see also prostate, other) Phase I Threshold (see also lung, pancreatic, Phase II San Diego, CA (858) 617-7600 Pharmaceuticals sarcoma) (650) 474-8200 neratinib Wyeth Pharmaceuticals monotherapy Phase III Redwood City, CA (HKI272) Collegeville, PA (see also lung) (800) 934-5556 GRN-163L Geron combination therapy Phase I/II combination therapy Phase I/II Menlo Park, CA (see also leukemia, lung, (650) 473-7700 (800) 934-5556 multiple myeloma) NeuVax™ Apthera (see also prostate) Phase II HER2-antigen- Genentech Phase II E75 cancer Scottsdale, AZ (480) 882-8841 specific cancer South San Francisco, (650) 224-1000 vaccine immuno- CA Nexavar® Bayer HealthCare combination therapy Phase II therapeutic sorafenib Pharmaceuticals (see also lung, skin) (888) 842-2937 HER2/neu GlaxoSmithKline Phase I/II Wayne, NJ (510) 597-6500 vaccine Rsch. Triangle Park, (888) 825-5249 Onyx Pharmaceuticals NC Emeryville, CA LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 5

5 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

NOV-002 Novelos Therapeutics early-stage breast cancer Phase II TamoGel™ ASCEND Therapeutics Phase II Newton, MA (see also lung, ovarian) (617) 244-1616 afimoxifene Herndon, VA (703) 471-4744 OBP-301 Oncolys Biopharma (see also head/neck, Phase I Tarceva® Genentech (see also bladder, brain, Phase II Tokyo, Japan lung) www.oncolys.com erlotinib South San Francisco, colorectal,head/neck, (650) 224-1000 OGX-427 Oncogenex (see also bladder, lung, Phase I CA liver, lung, other) (800) 572-1932 Pharmaceuticals ovarian, prostate) (425) 686-1500 OSI Pharmaceuticals Bothell, WA Melville, NY OPT-22 Optimer Phase I TAS-108 Taiho Pharma USA Phase II

Pharmaceuticals (858) 909-0736 Princeton, NJ (609) 750-5300 oncology-times.com San Diego, CA Telcyta™ Telik (see also colorectal, Phase II panobinostat Novartis (see also brain, Phase I/II canfosfamide Palo Alto, CA lung, ovarian) completed Pharmaceuticals leukemia, (888) 669-6682 (650) 845-7700 East Hanover, NJ lymphoma, prostate) tesmilifene YM BioSciences (see also prostate) Phase III patupilone Novartis (see also brain, Phase II Wayne, PA (610) 560-0600 (EPO906) Pharmaceuticals colorectal, liver, (888) 669-6682 TheraCIM™ YM Biosciences adjunctive treatment Phase I East Hanover, NJ lung, ovarian) nimotuzumab Wayne, PA (see also brain, prostate, (610) 560-0600 PD-332991 Pfizer combination therapy, Phase I/II stomach) New York, NY first-line therapy (860) 732-5156 Thermodox™ Celsion locally recurrent breast Phase I/II (see also lymphoma, LTSDEL Columbia, MD cancer (see also liver) (410) 290-5390 multiple myeloma) Genentech first-line therapy, Phase III - Genentech metastatic breast cancer Phase III South San Francisco, metastatic breast cancer (650) 224-1000 DM1 South San Francisco, (second-line therapy) (650) 225-1000 CA (see also ovarian) CA (781) 895-0600 ImmunoGen PTC-299 PTC Therapeutics (see also skin) Phase I/II Waltham, MA South Plainfield, NJ (908) 222-7000 metastatic breast cancer Phase II PX-1032 BN ImmunoTherapeutics Phase I/II (first-line therapy, (650) 225-1000 (HER2 breast Mountain View, CA (650) 681-4660 third-line therapy) (781) 895-0600 cancer vaccine) Pharmexa ® Horsholm, Denmark Trelstar Watson Pharmaceuticals Phase III Corona, CA (951) 493-5300 Quinamed® ChemGenex (see also ovarian, prostate) Phase II amonafide Pharmaceuticals (650) 474-9800 tremelimumab Pfizer (see also colorectal, Phase I Menlo Park, CA New York, NY kidney, lung, prostate, (860) 732-5156 skin) R1507 Roche combination therapy Phase II Nutley, NJ (see also lung, (973) 235-5000 trilostane Genzyme (see also prostate) in clinical trials lymphoma, sarcoma) Cambridge, MA (617) 252-7500 retaspimycin Infinity (see also lung, stomach) Phase II vinflunine Pierre Fabre advanced breast cancer Phase III (IPI 504) Pharmaceuticals (617) 453-1000 Pharmaceuticals (see also bladder) (973) 898-1042 Cambridge, MA Parsippany, NJ Reximmune-C™ Epeius Phase I/II WX-671 Wilex Phase II (626) 441-6695 Munich, www.wilex.com San Marino, CA Yondelis® Johnson & Johnson (see also ovarian, Phase II Rexin-G™ Epeius Biotechnologies recurrent, refractory Phase I/II Pharmaceutical prostate, (800) 817-5286 tumor-targeted San Marino, CA metastatic breast cancer (626) 441-6695 Research sarcoma, other) gene therapy (see also pancreatic, & Development sarcoma) Raritan, NJ sagopilone Bayer HealthCare (see also brain, ovarian, Phase II Zactima® AstraZeneca (see also brain, lung, Phase II Pharmaceuticals prostate) (888) 842-2937 vandetanib Wilmington, DE other) (800) 236-9933 Wayne, NJ Zolinza® Merck (see also brain, colorectal, Phase II Sarasar™ Schering-Plough (see also leukemia, Phase II vorinostat Whitehouse Station, kidney, leukemia, (800) 672-6372 lonafarnib Kenilworth, NJ pancreatic) (908) 298-4000 NJ lung, lymphoma, Spectrum metastatic breast cancer, Phase II multiple myeloma) Pharmaceuticals second-line therapy completed ZYC300 Eisai (see also colorectal, Phase I Irvine, CA (see also lung, prostate) (949) 788-6700 Woodcliff Lake, NJ kidney, ovarian, (888) 422-4743 SCH-727965 Schering-Plough (see also leukemia, lung) Phase II prostate) Kenilworth, NJ (908) 298-4000 SF1 SonneMed advanced breast cancer Phase I/II Cervical Cancer Boston, MA A-007 Tigris Pharmaceuticals cervical intraepithelial Phase II SNDX-275 Syndax (see also lung) Phase II Bonita Springs, FL neoplasia completed Pharmaceuticals (781) 839-7301 (see also colorectal) (239) 444-5400 Waltham, MA Armala™ GlaxoSmithKline (see also brain, breast, Phase II SU-14813 Pfizer Phase II pazopanib Rsch. Triangle Park, kidney, liver, lung, (888) 825-5249 New York, NY (860) 732-5156 NC ovarian, sarcoma, other) Sutent® Pfizer (see also colorectal, liver, Phase III Camptosar® Pfizer (see also lung, application sunitinib New York, NY lung, pancreatic, prostate,(860) 732-5156 New York, NY pancreatic, prostate) submitted sarcoma, stomach) (860) 732-5156

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6 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

HspE7 Nventa cervical intraepithelial Phase I axitinib Pfizer combination first-line Phase II (verpasep Biopharmaceuticals neoplasia completed New York, NY therapy (see also (860) 732-5156 caltespen) San Diego, CA (858) 202-4900 kidney, lung, solid Levulan® PD DUSA Pharmaceuticals cervical intraepithelial Phase II tumors, other) aminolevulinic Wilmington, DE neoplasia (see also (978) 657-7500 metastatic colorectal Phase II acid bladder, colorectal, cancer (combination (860) 732-5156 lung, stomach) second-line therapy) Multikine® CEL-SCI cervical cancer, cervical Phase I/II belinostat TopoTarget USA (see also bladder, Phase I leukocyte Vienna, VA dysplasia (see also completed Rockaway, NJ leukemia, liver, lung, (973) 895-6900 oncology-times.com head/neck) (703) 506-9460 lymphoma, ovarian) PV701 Wellstat Biologics (see also colorectal) Phase II brivanib Bristol-Myers Squibb metastatic colorectal Phase III Gaithersburg, MD (240) 631-2500 (VEGFR/FGFR Princeton, NJ cancer (combination (212) 546-4000 R3484 Roche cervical intraepithelial Phase II kinase inhibitor) with cetuximab) (MVA-HPV- Nutley, NJ neoplasia (973) 235-5000 (see also liver) IL2 vaccine) CDX-1307 Celldex Therapeutics (see also bladder, breast, Phase I TAK-851 Millennium cervical dysplasia Phase II Needham, MA ovarian, pancreatic) (781) 433-0771 Pharmaceuticals (800) 390-5663 Amgen (see also lung, pancreatic, Phase II Cambridge, MA Thousand Oaks, CA sarcoma) (805) 447-1000 terameprocol Erimos Pharmaceuticals cervical intraepithelial Phase II CP-751871 Pfizer (see also breast, lung, Phase II Houston, TX neoplasia (see also (713) 541-2000 New York, NY multiple myeloma, (860) 732-5156 brain, head/neck) prostate, sarcoma) tirapazamine SRI International Phase III CPX-1 Celator Pharmaceuticals Phase II Menlo Park, CA (650) 859-2000 Princeton, NJ (609) 243-0123 V503 Merck cervical cancer Phase III Davanat™ Pro-Pharmaceuticals (see also solid tumors) Phase II Whitehouse prevention (800) 672-6372 galactomannan C Newton, MA (617) 559-0033 Station, NJ (see also other) denenicokin ZymoGenetics combination therapy Phase I V505 Merck Phase III (IL-21) Seattle, WA (see also kidney, (206) 442-6600 Whitehouse Station, (800) 672-6372 lymphoma, NJ ovarian, skin) edotecarin Pfizer Phase III Colorectal Cancer New York, NY (860) 732-5156 1018 ISS Dynavax Technologies (see also lymphoma) Phase I enzastaurin Eli Lilly combination therapy Phase II Berkeley, CA (510) 848-5100 (LY317615) Indianapolis, IN (see also brain, breast, (800) 545-5979 A-007 Tigris Pharmaceuticals anal intraepithelial Phase I/II lymphoma, multiple Bonita Springs, FL neoplasia (239) 444-5400 myeloma, ovarian, (see also cervical) prostate) ABT-751 Abbott Laboratories (see also breast, Phase II Erbitux® Bristol-Myers Squibb adjuvant, first-line, Phase III Abbott Park, IL kidney, lung) (847) 937-6100 cetuximab Princeton, NJ second-line colorectal (212) 546-4000 aflibercept sanofi-aventis second-line metastatic Phase III Eli Lilly cancer (see also bladder, (800) 545-5979 (VEGF-trap) Bridgewater, NJ colorectal cancer (800) 633-1610 Indianapolis, IN head/neck, lung, (212) 645-1405 Regeneron (combination therapy)(914) 345-7400 ImClone Systems prostate, stomach) Pharmaceuticals (see also lung, pancreatic, New York, NY rectal cancer Phase II Tarrytown, NY prostate, other) (212) 546-4000 AMG 102 Amgen (see also brain, kidney, Phase I/II (800) 545-5979 Thousand Oaks, CA lung, stomach) (805) 447-1000 (212) 645-1405 AMG 479 Amgen (see also breast, lung, Phase II Fusilev™ Spectrum (see also sarcoma) application Thousand Oaks, CA pancreatic, sarcoma) (805) 447-1000 levoleucovorin Pharmaceuticals submitted AMG 951 Amgen (see also lymphoma) Phase I for injection Irvine, CA (949) 788-6700 (rhApo2L/ Thousand Oaks, CA (805) 447-1000 Herceptin® Genentech (see also ovarian, Phase II TRAIL) Genentech (650) 225-1000 trastuzumab South San Francisco, pancreatic, prostate, (650) 225-1000 South San Francisco, CA CA stomach, other) apomab Genentech South (see also lung, Phase I huA33 Life Science Phase I San Francisco, CA lymphoma) (650) 225-1000 Pharmaceuticals (203) 422-6500 AR-726 Antigenics (see also lymphoma) Phase II Greenwich, CT New York, NY (212) 994-8200 Hycamtin® GlaxoSmithKline (see also breast, Phase II Avastin® Genentech adjuvant treatment Phase III topotecan Rsch. Triangle Park, head/neck, kidney, (888) 825-5249 bevacizumab South San Francisco, (see also brain, head (650) 225-1000 NC leukemia, lung, CA /neck, kidney, liver, lymphoma, multiple lung, lymphoma, myeloma, ovarian, multiple myeloma, pancreatic, prostate, ovarian, pancreatic, stomach, other) prostate, stomach, other) IMC-1121B Eli Lilly (see also breast, kidney, Phase II AVX701 AlphaVax colorectal cancer Phase I/II Indianapolis, IN liver, lung, ovarian, (800) 545-5979 Rsch. Triangle Park, prevention (919) 595-0400 ImClone Systems prostate, skin) (212) 645-1405 NC New York, NY LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 7

7 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

IMC-A12 Eli Lilly (see also breast, Phase II Schering-Plough (see also sarcoma) Phase II Indianapolis, IN head/neck, liver, lung, (800) 545-5979 Kenilworth, NJ (908) 298-4000 ImClone Systems pancreatic, prostate, (212) 645-1405 Life Science (see also head/neck, Phase II New York, NY sarcoma, solid tumors) Pharmaceuticals lung) (203) 422-6500 IMO-2055 Idera Pharmaceuticals combination therapy Phase I Greenwich, CT Cambridge, MA (see also kidney, lung) (617) 679-5500 Sutent® Pfizer (see also breast, liver, Phase II ispinesib CytoKinetics South (see also breast, kidney, Phase II sunitinib New York, NY lung, pancreatic, (860) 732-5156 San Francisco, CA leukemia) (650) 624-3000 prostate, sarcoma,

KRN-330 Kirin Pharma USA Phase I stomach) oncology-times.com La Jolla, CA (858) 952-7000 systemic Genentech first-line therapy Phase II KRX-0402 Keryx (see also brain, kidney, Phase I hedgehog South San Francisco, (see also brain, ovarian, (650) 224-1000 Biopharmaceuticals multiple myeloma, (212) 531-5965 antagonist CA skin) New York, NY sarcoma) Tarceva® Genentech combination therapy Phase II lapuleucel-T Dendreon (see also breast, ovarian) Phase I erlotinib South San Francisco, (see also bladder, brain, (650) 224-1000 Seattle, WA completed CA breast, head/neck, liver, (800) 572-1932 (206) 256-4545 OSI Pharmaceuticals lung, other) LE-SN38 NeoPharm second-line therapy Phase II Melville, NY Lake Bluff, IL (847) 887-0800 TAS-109 Taiho Pharma USA Phase II Levulan® PD DUSA Pharmaceuticals (see also bladder, in clinical trials Princeton, NJ (609) 750-5300 aminolevulinic Wilmington, MA cervical, lung, (978) 657-7500 /uracil EMD Serono (see also head/neck) Phase III acid stomach) combination Rockland, MA (800) 283-8088 Litx™ Light Sciences Oncology metastatic colorectal Phase III Telcyta™ Telik (see also breast, lung, Phase II Bellevue, WA cancer (425) 957-8900 canfosfamide Palo Alto, CA ovarian) completed LOR-2040 Lorus Therapeutics metastatic colorectal Phase II (650) 845-7700 Toronto, Canada cancer (see also breast, (416) 798-1200 Genta second-line therapy Phase II kidney, leukemia) Berkeley Heights, NJ (see also stomach) (908) 286-9800 milataxel Taxolog (see also breast, lung) Phase II tetrandrine Millenia Hope Phase III Fairfield, NJ (877) 829-6564 Montreal, Canada (514) 846-5757 motesanib Amgen metastatic colorectal Phase I Thymitaq® YM BioSciences USA (see also head/neck, Phase II Thousand Oaks, CA cancer (combination (805) 447-1000 nolatrexed Wayne, PA liver, lung, pancreatic, (610) 560-0600 Millennium therapy) (see also (800) 390-5663 prostate) Pharmaceuticals breast, lung, other) Cambridge, MA TNFerade™ GenVec (see also head/neck, Phase II NKTR-102 Nektar Therapeutics combination, Phase II Gaithersburg, MD pancreatic, skin, (240) 632-0740 San Carlos, CA second-line therapy (650) 631-3100 stomach) (see also ovarian) Torisel™ Wyeth Pharmaceuticals (see also kidney, lung, Phase II Oncophage® Antigenics (see also brain, kidney, Phase II temsirolimus Collegeville, PA lymphoma, multiple (800) 934-5556 vitespen New York, NY pancreatic, skin, (866) 805-8994 myeloma, prostate) stomach) tremelimumab Pfizer (see also breast, kidney, Phase II OncoVAX® Vaccinogen stage III colorectal Phase II New York, NY lung, prostate, skin) (860) 732-5156 cancer vaccine Frederick, MD cancer (combination (301) 668-8400 tucotuzumab EMD Serono (see also lung, ovarian, Phase II therapy) (see also celmoleukin Rockland, MA prostate) (800) 283-8088 kidney, skin) Urso Forte™ Axcan Pharma (see also cancer-related) Phase II colorectal cancer Phase I/II ursodeoxycholic Birmingham, AL (205) 991-8085 (301) 668-8400 acid patupilone Novartis (see also brain, breast, Phase I/II VP101 Access Pharmaceuticals (see also brain, leukemia, Phase II (EPO906) Pharmaceuticals liver, lung, (888) 669-6682 Dallas, TX prostate) (214) 905-5100 East Hanover, NJ ovarian) Xeloda® Roche first-line metastatic application pelitinib Wyeth Pharmaceuticals second-line therapy Phase II Nutley, NJ colorectal cancer, submitted (EKB569) Collegeville, PA (see also lung) (800) 934-5556 second-line metastatic (973) 235-5000 picoplatin Poniard (see also lung) Phase II colorectal cancer Pharmaceuticals (206) 281-7001 (see also stomach) Seattle, WA Zolinza® Merck (see also brain, breast, Phase I PN401 Wellstat Therapeutics (see also pancreatic, Phase I vorinostat Whitehouse Station, NJ kidney, leukemia, lung, (800) 672-6372 Gaithersburg, MD stomach) (240) 631-2500 lymphoma, multiple PV701 Wellstat Biologics (see also cervical) Phase II myeloma) Gaithersburg, MD (240) 631-2500 ZYC300 Eisai colon cancer Phase I RIGScan® Neoprobe diagnosis of colorectal Phase III Woodcliff Lake, NJ (see also breast, kidney, (888) 422-4743 CR49 Dublin, OH cancer (800) 793-0079 ovarian, prostate) radiodiagnostic agent Head/Neck Cancer RM1812 Royalmount Phase I Abraxane™ Abraxis BioScience (see also lung, ovarian, Phase I/II Pharmaceuticals (514) 340-7849 albumin-bound Los Angeles, CA pancreatic, prostate, (310) 883-1300 Montreal, Canada skin)

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8 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Advexin® Introgen Therapeutics (see also bladder, brain, Phase III SCH-58500 Schering-Plough (see also bladder, liver, Phase I contusugene Austin, TX breast, lung, ovarian, completed (p53 gene Kenilworth, NJ lung, cancer-related) (908) 298-4000 ladenovec prostate, stomach) (512) 708-9310 therapy) (Orphan Drug) sibrotuzumab Life Science (see also colorectal, Phase II Alimta® Eli Lilly (see also breast, lung, Phase III Pharmaceuticals lung) (203) 422-6500 pemetrexed Indianapolis, IN ovarian) (800) 545-5979 Greenwich, CT AP-5346 Access Pharmaceuticals Phase II Tarceva® Genentech resected head/neck Phase III Dallas, TX (214) 905-5100 erlotinib South San Francisco, squamous cell cancer (650) 224-1000 CA (see also bladder, brain, (800) 572-1932 oncology-times.com ARQ-501 ArQule (see also pancreatic, Phase II (beta lapachone) Woburn, MA solid tumors, other) (781) 994-0300 OSI Pharmaceuticals breast, colorectal, liver, Melville, NY lung, other) Avastin® Genentech combination therapy Phase III bevacizumab South San Francisco, (see also brain, colorectal, (650) 225-1000 TAS-106 Taiho Pharma USA Phase II CA kidney, liver, lung, Princeton, NJ (609) 750-5300 lymphoma, multiple tegafur/uracil EMD Serono (see also colorectal) Phase II myeloma, ovarian, combination Rockland, MA (800) 283-8088 pancreatic, prostate, terameprocol Erimos Pharmaceuticals (see also brain, cervical) Phase I stomach, other) Houston, TX (713) 541-2000 BIBW 2992 Boehringer Ingelheim second-line therapy Phase II Thymitaq® YM BioSciences (see also colorectal, liver, Phase II Pharmaceuticals (see also brain, breast, (800) 243-0127 nolatrexed Wayne, PA lung, pancreatic, (610) 560-0600 Ridgefield, CT lung) prostate) bleomycin Inovio Biomedical (see also breast) Phase III TNFerade™ GenVec (see also colorectal, Phase I/II (electrical pulse San Diego, CA (858) 597-6006 Gaithersburg, MD pancreatic, skin, (240) 632-0740 delivery) stomach) ® Erbitux Bristol-Myers Squibb first-line application Tykerb® GlaxoSmithKline (see also brain, Phase III cetuximab Princeton, NJ (see also bladder, submitted lapatinib Rsch. Triangle Park, stomach) (888) 825-5249 Eli Lilly colorectal, lung, (212) 546-4000 NC Indianapolis, IN prostate, stomach) (800) 545-5979 VB-4845 Viventia Biotech (see also bladder) Phase II ImClone Systems (212) 645-1405 (Orphan Drug) Mississauga, Canada (905) 361-8686 New York, NY Vectibix™ Amgen first-line therapy Phase III eribulin mesylate Eisai (see also breast, lung, Phase II Thousand Oaks, CA (see also lung) (805) 447-1000 (E7389) Woodcliff Lake, NJ ovarian, prostate, (888) 422-4743 sarcoma, solid tumors) second-line therapy Phase II (805) 447-1000 Gemzar® Eli Lilly (see also lung, Phase I Indianapolis, IN lymphoma, sarcoma) (800) 545-5979 XL-880 Exelixis (see also kidney, Phase II South San Francisco, stomach) (650) 837-7000 Hycamtin® GlaxoSmithKline (see also breast, Phase II CA (888) 825-5249 topotecan Rsch. Triangle Park, colorectal, kidney, (888) 825-5249 GlaxoSmithKline NC leukemia, lung, Rsch. Triangle Park, NC lymphoma, multiple myeloma, ovarian, Genmab Phase II pancreatic, prostate, Princeton, NJ (609) 430-2481 stomach, other) Zybrestat™ OXiGENE (see also lung, ovarian, Phase I/II IMC-A12 Eli Lilly (see also breast, Phase II fosbretabulin Waltham, MA other) (781) 547-5900 Indianapolis, IN colorectal, liver, lung, (800) 545-5979 Kidney Cancer ImClone Systems pancreatic, prostate, (212) 645-1405 New York, NY sarcoma, solid tumors) ABT-751 Abbott Laboratories (see also breast, Phase II ING 234 Colgate-Palmolive orofacial cancer Phase II Abbott Park, IL colorectal, lung) (847) 937-6100 (mouthwash) New York, NY (prevention) (512) 708-9310 ABT-869 Abbott Laboratories (see also breast, liver, Phase II Introgen Therapeutics Abbott Park, IL lung) (847) 937-6100 Austin, TX Genentech (650) 225-1000 INGN 241 Introgen Therapeutics combination therapy Phase III South San Francisco, (mda-7) Austin, TX (see also skin) (512) 708-9310 CA IRX-2 IRX Therapeutics Phase II AGS-003 Argos Therapeutics metastatic renal cancer Phase II New York, NY (212) 582-1199 Durham, NC (919) 287-6300 Multikine® CEL-SCI (see also cervical) Phase II AMG 102 Amgen (see also brain, colorectal, Phase II leukocyte Vienna, VA (703) 506-9460 Thousand Oaks, CA lung, stomach) (805) 447-1000 interleukin AMG 386 Amgen (see also breast, ovarian, Phase II OBP-301 Oncolys Biopharma (see also breast, lung) Phase I Thousand Oaks, CA stomach, other) (805) 447-1000 Tokyo, Japan www.oncolys.com Armala™ GlaxoSmithKline late-stage metastatic Phase III perifosine AEterna Zentaris (see also brain, kidney, Phase II pazopanib Rsch. Triangle Park, kidney cancer (see also (888) 825-5249 Montreal, Canada lymphoma, multiple (212) 531-5965 NC brain, breast, cervical, Keryx myeloma, ovarian, liver, lung, ovarian, Biopharmaceuticals sarcoma) sarcoma, other) New York, NY AS-1411 Antisoma (see also leukemia) Phase II Reolysin® Oncolytics Biotech combination therapy Phase II (Orphan Drug) Cambridge, MA (617) 225-0522 reovirus Calgary, Canada (see also brain, lung, (403) 670-7377 AV-951 AVEO Pharmaceuticals combination therapy Phase I sarcoma, skin) Cambridge, MA (see also lung, stomach) (617) 299-5000 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 9

9 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

Avastin® Genentech first-line metastatic renal application Oncophage® Antigenics (see also brain, Phase II bevacizumab South San Francisco, cell carcinoma (see also submitted vitespen New York, NY colorectal, pancreatic, (866) 805-8994 CA brain, colorectal, (650) 225-1000 skin, stomach) head/neck, liver, lung, OncoVAX® Vaccinogen (see also colorectal, Phase I/II lymphoma, multiple cancer vaccine Frederick, MD skin) (301) 668-8400 myeloma, ovarian, Spectrum (see also lymphoma) Phase II pancreatic, prostate, Pharmaceuticals (949) 788-6700 stomach, other) Irvine, CA axitinib Pfizer second-line therapy Phase III

perifosine AEterna Zentaris (see also brain, Phase II oncology-times.com New York, NY (see also colorectal, (860) 732-5156 Montreal, Canada head/neck, lymphoma, (212) 531-5965 lung, solid tumors, other) Keryx multiple myeloma, BAY 73-4506 Bayer HealthCare Phase II Biopharmaceuticals ovarian, sarcoma) Pharmaceuticals (888) 842-2937 New York, NY Wayne, NJ Rencarex® Wilex non-metastatic, clear Phase III CA9-SCAN Wilex Munich, diagnosis of kidney Phase III W-G250 Munich, Germany cell renal cell carcinoma www.wilex.com Germany cancer www.wilex.com (Orphan Drug) cediranib AstraZeneca (see also breast, Phase II Gloucester (see also lymphoma, Phase II Wilmington, DE leukemia) (800) 236-9933 Pharmaceuticals multiple myeloma, completed CNTO 328 Centocor (see also prostate) Phase I Cambridge, MA pancreatic, prostate) (617) 583-1300 Horsham, PA (610) 651-6000 RX-0201 Rexahn Pharmaceuticals late-stage kidney Phase II CYT-107 Cytheris (see also leukemia, skin, Phase I/II (Orphan Drug) Rockville, MD cancer (240) 268-5300 Rockville, MD solid tumors) (301) 231-0450 talactoferrin Agennix (see also lung) Phase II denenicokin ZymoGenetics combination therapy Phase II (Orphan Drug) Houston, TX (713) 552-1091 (IL-21) Seattle, WA (see also colorectal, (206) 442-6600 Torisel™ Wyeth Pharmaceuticals first-line therapy, Phase III lymphoma, temsirolimus Collegeville, PA late-stage kidney (800) 934-5556 ovarian, skin) (Orphan Drug) cancer (see also dovitinib Novartis (see also skin) Phase I/II colorectal, lung, Pharmaceuticals (888) 669-6682 lymphoma, multiple East Hanover, NJ myeloma, prostate) EC-17 Endocyte combination therapy Phase II tremelimumab Pfizer (see also breast, Phase I West Lafayette, IN (765) 463-7175 New York, NY colorectal, lung, (860) 732-5156 everolimus Novartis (see also pancreatic, application prostate, skin) Pharmaceuticals other) submitted TroVax® BioMedica Phase III East Hanover, NJ (888) 669-6682 (SAR109659) San Diego, CA (858) 677-6500 GC-1008 Genzyme (see also skin) Phase I sanofi-aventis (800) 633-1610 Cambridge, MA (617) 252-7000 Bridgewater, NJ ® Hycamtin® GlaxoSmithKline (see also breast, Phase II Xcytrin Pharmacyclics (see also brain, Phase II topotecan Rsch. Triangle Park, colorectal, (888) 825-5249 motexafin Sunnyvale, CA leukemia, lung, (408) 774-0330 NC head/neck, leukemia, gadolinium lymphoma) lung, lymphoma, XL-880 Exelixis (see also head/neck, Phase II multiple myeloma, South San Francisco, stomach) (650) 837-7000 ovarian, pancreatic, CA (888) 825-5249 prostate, stomach, other) GlaxoSmithKline IMC-1121B Eli Lilly metastatic kidney Phase II Rsch. Triangle Park, NC Indianapolis, IN cancer (see also breast, (800) 545-5979 Zolinza® Merck (see also brain, breast, Phase I/II ImClone Systems colorectal, liver, (212) 645-1405 vorinostat Whitehouse colorectal, leukemia,(800) 672-6372 New York, NY lung, ovarian, prostate, Station, NJ lung, lymphoma, skin) multiple myeloma) IMO-2055 Idera Pharmaceuticals (see also colorectal, Phase II ZRx101 ZelleRx (see also multiple Phase I Cambridge, MA lung) completed Chicago, IL myeloma, skin, (312) 243-5200 (617) 679-5500 cancer-related) ispinesib CytoKinetics South (see also breast, Phase II ZYC300 Eisai (see also breast, Phase I San Francisco, CA colorectal, leukemia) (650) 624-3000 Woodcliff Lake, NJ colorectal, (888) 422-4743 KRX-0402 Keryx (see also brain, Phase I ovarian, prostate) Biopharmaceuticals colorectal, multiple (212) 531-5965 New York, NY myeloma, sarcoma) Leukemia LOR-2040 Lorus Therapeutics metastatic kidney Phase II ABIO05/01 Abiogen Pharma chronic myeloid Phase II (Orphan Drug) Toronto, Canada cancer (416) 798-1200 (TALL-104) Pisa, leukemia (CML) (see also breast, (combination therapy) colorectal, leukemia) Ablvax™ Breakthrough CML Phase II MDX-1411 Medarex clear-cell renal cell Phase I (VAXICO) Therapeutics Princeton, NJ carcinoma (609) 430-2880 Greenwich, CT naptumomab Active Biotech (see also lung, Phase I ABT-263 Abbott Laboratories chronic lymphocytic Phase I/II estafenatox Lund, Sweden pancreatic) completed Abbott Park, IL leukemia (CLL) (847) 937-6100 www.active Genentech South (see also lung, (650) 225-1000 biotech.com San Francisco, CA lymphoma)

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10 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

AC220 Ambit Biosciences Phase I bosutinib Wyeth Pharmaceuticals CML Phase III San Diego, CA (AML) (858) 334-2100 Collegeville, PA (see also breast, (800) 934-5556 AEG-35156 Aegera Therapeutics AML (combination Phase II solid tumors) Montreal, Canada therapy) (514) 288-5532 ALL Phase I/II AEG-41174 Aegera Therapeutics hematological Phase I (800) 934-5556 Montreal, Canada malignancies (514) 288-5532 CAL-101 Calistoga AML, CLL Phase I (combination therapy) Pharmaceuticals (see also lymphoma) (206) 728-4700 AEW541 Novartis hematological Phase I Seattle, WA ®

oncology-times.com Pharmaceuticals malignancies (888) 669-6682 Campath Bayer HealthCare CLL Phase II East Hanover, NJ (see also solid tumors) Pharmaceuticals (888) 842-2937 Aezea™ Eleos Omaha, NE AML, CLL Phase II (subcutaneous) Wayne, NJ cenersen (402) 255-5775 (Orphan Drug) AFX-9154 Afecta Pharmaceuticals in clinical trials Proteolix hematological Phase I Irvine, CA (949) 253-4688 South San Francisco, malignancies (650) 615-7550 CA (see also multiple ALD-151 Aldagen adjunctive treatment Phase I myeloma, solid tumors) Durham, NC (adolescents and (919) 484-2571 children) CAT-8015 MedImmune CLL, hairy cell leukemia Phase I Gaithersburg, MD (see also lymphoma) (301) 398-0000 sanofi-aventis CLL Phase III Bridgewater, NJ (800) 633-1610 cediranib AstraZeneca AML in children Phase I Wilmington, DE (see also breast, kidney) (800) 236-9933 ALXN-6000 CLL Phase I/II ® Cheshire, CT (203) 272-2596 Ceflatonin ChemGenex CML (second-line application omacetaxine Pharmaceuticals therapy) submitted annamycin Callisto Pharmaceuticals acute lymphocytic Phase I/II mepesuccinate Menlo Park, CA (650) 474-9800 liposomal New York, NY leukemia (ALL), AML (212) 297-0010 (Orphan Drug) (Orphan Drug) AML, CML Phase II AP24534 ARIAD Pharmaceuticalshematological Phase I (combination therapy), (650) 474-9800 Cambridge, MA malignancies (617) 494-0400 myelodysplastic ARRY-520 Array BioPharma AML Phase I/II syndromes Boulder, CO (see also solid tumors) (303) 381-6600 cell permeation MaxCyte CLL Phase I/II AS-1411 Antisoma Cambridge, AML (combination Phase II therapeutic Gaithersburg, MD (301) 944-1700 MA therapy) (see also kidney) (617) 225-0522 Ceplene™ EpiCept AML Phase III AS-1413 Antisoma AML Phase III histamine Tarrytown, NY completed (Orphan Drug) Cambridge, MA (combination therapy) (617) 225-0522 dehydrochloride (914) 606-3500 AT9283 Astex Therapeutics hematological Phase I/II (Orphan Drug) Cambridge, malignancies (see also Clolar® Genzyme AML application United Kingdom solid tumors) Cambridge, MA (see also lymphoma) submitted atacicept EMD Serono CLL Phase I (617) 252-7500 (TACI-Ig) Rockland, MA (see also lymphoma, (800) 283-8088 CLL, myelodysplastic Phase II ZymoGenetics multiple myeloma)(206) 442-6600 syndromes (617) 252-7500 Seattle, WA CNF-2024 Biogen Idec CLL (see also Phase I AVN-944 Avalon hematological Phase I Cambridge, MA breast, solid tumors, (617) 679-2000 Pharmaceuticals malignancies (301) 556-9900 stomach) Germantown, MD (see also pancreatic) CPX-351 Celator Pharmaceuticals AML Phase II AZD1152 AstraZeneca AML Phase I/II Princeton, NJ (609) 243-0123 Wilmington, DE (800) 236-9933 CYT-107 Cytheris myeloid leukemia Phase I AZD4877 AstraZeneca AML Phase I/II Rockville, MD (see also kidney, skin, (301) 231-0450 Wilmington, DE (see also lymphoma) (800) 236-9933 solid tumors) AZD6244 AstraZeneca AML Phase II Genentech CLL Phase I/II Wilmington, DE (see also liver, lung, (800) 236-9933 (anti-CD40) South San Francisco, (see also lymphoma, (650) 225-1000 multiple myeloma, (Orphan Drug) CA multiple myeloma) (425) 527-4000 ovarian, pancreatic, Seattle Genetics skin, other) Bothell, WA AZM475271 AstraZeneca hematological Phase II darinaparsin ZIOPHARM hematological Phase II Wilmington, DE malignancies (800) 236-9933 (ZIO-101) Oncology malignancies (646) 214-0700 (see also solid tumors) New York, NY (see also liver, multiple myeloma, bafetinib CytRx ALL, CML Phase I solid tumors) (Orphan Drug) Los Angeles, CA (310) 826-5648 DCC-2036 Deciphera ALL, CML Phase I/II belinostat TopoTarget USA AML, myelodysplastic Phase II Pharmaceuticals (785) 838-3767 Rockaway, NJ syndromes (see also (973) 895-6900 Lawrence, KS bladder, colorectal, Elacyt™ Clavis Pharma AML Phase II liver, lung, lymphoma, elacytarabine Oslo, Norway (see also ovarian, skin) www.clavis ovarian) (Orphan Drug) pharma. com ® Bexxar GlaxoSmithKline CLL Phase I Fodosine™ BioCryst CLL, leukemia Phase II Rsch. Triangle Park, (see also lymphoma, (888) 825-5249 Pharmaceuticals (see also lymphoma) (205) 444-4600 NC cancer-related) Birmingham, AL LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 11

11 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

GCS-100 Prospect Therapeutics CLL Phase II lestaurtinib Cephalon AML Phase II Woburn, MA (see also lymphoma, (781) 939-5750 Frazer, PA (see also multiple (610) 344-0200 multiple myeloma) myeloma) Genasense® Genta CLL application Leukine® Bayer HealthCare CLL Phase II oblimersen Berkeley Heights, NJ (see also breast, lung, submitted Pharmaceuticals (see also lymphoma, (888) 842-2937 (Orphan Drug) lymphoma, (908) 286-9800 Wayne, NJ ovarian, prostate, skin) skin, solid tumors) Facet Biotech AML (combination Phase II AML Phase III (SGN-33) Redwood City, CA therapy in elderly (650) 454-1000 (908) 286-9800 (Orphan Drug) Seattle Genetics patients) (425) 527-4000 oncology-times.com gimatecan Novartis myelodysplastic Phase I Seattle, WA Pharmaceuticals syndromes (888) 669-6682 myelodysplastic Phase I East Hanover, NJ (see also brain) syndromes (650) 454-1000 Gleevec® Novartis AML Phase II (425) 527-4000 imatinib Pharmaceuticals (see also prostate) (888) 669-6682 lintuzumab Actinium AML Phase I East Hanover, NJ Ac-225 Pharmaceuticals (973) 377-0713 GRN-163L Geron CLL Phase I/II Florham Park, NJ Menlo Park, CA (see also breast, lung, (650) 473-7700 LOR-2040 Lorus Therapeutics AML Phase II multiple myeloma) (Orphan Drug) Toronto, Canada (see also breast, (416) 798-1200 GRNVAC1 Argos Therapeutics AML Phase II colorectal, kidney) Durham, NC (see also prostate) (919) 287-6300 CML, myelodysplastic Phase I Geron (650) 473-7700 syndromes (416) 798-1200 Menlo Park, CA lumilixmab Biogen Idec CLL Phase II/III GS-9219 CLL Phase I/II (anti-CD23 Cambridge, MA (617) 679-2000 Foster City, CA (see also lymphoma) (800) 445-3235 mAb) HRC-302 Hemosol BioPharma CML Phase I LY2181308 Eli Lilly AML Phase I/II Mississauga, Canada (905) 286-6349 Indianapolis, IN (see also solid tumors) (800) 545-5979 Hycamtin® GlaxoSmithKline preleukemia Phase III Isis Pharmaceuticals (760) 931-9200 topotecan Rsch. Triangle Park, (see also breast, (888) 825-5249 Carlsbad, CA NC colorectal, head/neck, LymphoCide® Immunomedics ALL in children Phase II kidney, lung, epratuzumab Morris Plains, NJ (see also lymphoma) (973) 605-8200 lymphoma, multiple (Orphan Drug) myeloma, ovarian, Marqibo™ Hana Biosciences ALL Phase I/II pancreatic, prostate, South San Francisco, (see also skin) (650) 588-6404 stomach, other) liposomal CA CML Phase II (Orphan Drug) (888) 825-5249 masitinib AB Science USA mastocytosis Phase III INNO-305 CytRx AML, myelodysplastic Phase I Short Hills, NJ (see also pancreatic, (973) 218-2437 Los Angeles, CA syndromes (310) 826-5648 stomach) (see also solid tumors) MDX-1342 Medarex CLL Phase I ISF35 Memgen CLL Phase I Princeton, NJ (609) 430-2880 Dallas, TX (214) 731-3141 MGCD-0103 MethylGene AML, CLL, Phase II ispinesib CytoKinetics hematological Phase I Montreal, Canada myelodysplastic (514) 337-3333 South San Francisco, malignancies (650) 624-3000 syndromes (see also CA (see also breast, lymphoma, solid tumors) colorectal, kidney) midostaurin Novartis AML Phase III JNJ-26481585 Johnson & Johnson refractory metastatic Phase I (PKC412) Pharmaceuticals (888) 669-6682 Pharmaceutical leukemia, (800) 817-5286 East Hanover, NJ Research & refractory metastatic Immunomedics CLL Phase I/II Development myelodysplastic (IMMU-115) Morris Plains, NJ (see lymphoma, (973) 605-8200 Raritan, NJ syndromes multiple myeloma) JVRS-100 Juvaris BioTherapeutics Phase I MK-0752 Merck hematological Phase I Burlingame, CA (650) 259-1800 Whitehouse Station, malignancies (800) 672-6372 KW-2449 Kyowa Pharmaceutical ALL, AML, CML, Phase I NJ (see also breast) Princeton, NJ myelodysplastic (609) 919-1100 MKC 1 EntreMed hematological Phase I syndromes Rockville, MD malignancies completed laromustine Vion Pharmaceuticals AML (first-line therapy application (see aslo breast, (240) 864-2600 (VNP 40101M) New Haven, CT in elderly patients) submitted lung, pancreatic) (Orphan Drug) (see also brain) (203) 498-4210 MLN4924 Millennium hematological Phase I AML (combination Phase III Pharmaceuticals malignancies (800) 390-5663 second-line (203) 498-4210 Cambridge, MA (see also solid tumors) therapy) MLN8237 Millennium AML, myelodysplastic Phase II AML (combination Phase I/II Pharmaceuticals syndromes (see also (800) 390-5663 therapy in elderly (203) 498-4210 Cambridge, MA brain, lymphoma, patients), myelodysplastic solid tumors) syndromes (combination ALL Phase I/II therapy in elderly patients) (800) 390-5663

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12 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

MPC-2130 Myriad Pharmaceuticals hematological Phase I Revlimid® Celgene CLL Phase III Salt Lake City, UT malignancies (801) 584-3600 lenalidomide Summit, NJ (see also lymphoma, (908) 673-9000 Nipent® CLL Phase III multiple myeloma, Lake Forest, IL (see also lymphoma, (224) 212-2000 prostate, other) (Orphan Drug) cancer-related) AML Phase II Nplate™ Amgen myelodysplastic Phase II (908) 673-9000 romiplostim Thousand Oaks, CA syndromes (see also (805) 447-1000 Rituxan® Biogen Idec relapsed CLL Phase III cancer-related) rituxumab Cambridge, MA (617) 679-2000 Genentech (650) 225-1000 oncology-times.com obatoclax Gemin X AML in elderly Phase II Biotechnologies patients, myelodysplastic (514) 281-8989 South San Francisco, CA Montreal, Canada syndromes (see also RTA-402 Reata Pharmaceuticals hematological Phase I lung, lymphoma) Dallas, TX malignancies (972) 865-2200 CLL Phase I/II (see also pancreatic) completed AML in elderly Phase II (514) 281-8989 Pharmaceuticals patients, (973) 847-5955 GlaxoSmithKline CLL (second-line application Short Hills, NJ myelodysplastic Rsch. Triangle Park, therapy) submitted syndromes in NC (see also lymphoma) (888) 825-5249 elderly patients (see also lung, lymphoma) CLL (first-line therapy) Phase III (888) 825-5249 Sarasar™ Schering-Plough myelodysplastic Phase III lonafarnib Kenilworth, NJ syndromes (908) 298-4000 ON-01910 Onconova Therapeutics AML, myelodysplastic Phase I (see also breast, Princeton, NJ syndromes (609) 844-7735 pancreatic) (see also solid tumors) leukemia Phase II OVI-123 OncoVista TdT-positive leukemia Phase I/II (908) 298-4000 (Orphan Drug) San Antonio, TX (210) 677-6000 SB-1518 S*Bio (see also lymphoma) Phase I panobinostat Novartis CML Phase II/III Redwood City, CA (650) 730-2860 Pharmaceuticals (see also brain, breast, completed East Hanover, NJ lymphoma, prostate) (888) 669-6682 SCH-727965 Schering-Plough (see also breast, lung) Phase II Kenilworth, NJ (908) 298-4000 AML Phase II (888) 669-6682 SGN-35 Seattle Genetics hematological Phase I Bothell, WA malignancies (see also (425) 527-4000 PCI-24781 Pharmacyclics hematological Phase II lymphoma) Sunnyvale, CA malignancies (see also (408) 774-0330 solid tumors) SL-401 Stemline Therapeutics AML Phase I/II New York, NY (212) 831-1111 PEG-Intron A® Schering-Plough CML Phase II peginterferon Kenilworth, NJ (see also skin) (908) 298-4000 SNS-595 Sunesis AML in elderly Phase II alfa-2b Pharmaceuticals patients (see also (650) 266-3500 South San Francisco, ovarian) PHA-739358 Nerviano CML Phase II CA Medical Sciences www.nervia Nerviano, Italy noms.com AML Phase I/II (combination therapy) (650) 266-3500 polyphenon E Polyphenon Pharma CLL Phase I/II (Orphan Drug) New York, NY (see also bladder, (212) 661-0578 AML (monotherapy) Phase I prostate) (650) 266-3500 PR1 cancer Vaccine Company AML Phase III SPC-2996 Santaris Pharma CLL Phase I/II vaccine South San Francisco, CA (650) 244-4100 Horsholm, Denmark completed CML, myelodysplastic Phase II Sprycel™ Bristol-Myers Squibb first-line CML Phase III syndromes (650) 244-4100 dasatinib Princeton, NJ (see also prostate, (212) 546-4000 solid tumors) PRO-131921 Genentech CLL Phase I/II South San Francisco, (see also (650) 224-1000 other hematological in clinical trials CA lymphoma) malignancies (212) 546-4000 Proleukin® Novartis AML Phase III STA-9090 Synta Pharmaceuticals hematological Phase I/II aldesleukin Pharmaceuticals (888) 669-6682 Lexington, MA malignancies (781) 274-8200 East Hanover, NJ (see also solid tumors) ® PS-095760 Ligand (see also lung) Phase II StemEx Gamida Cell hematological Phase II/III Pharmaceuticals (858) 550-7500 hematopoietic Jerusalem, Israel malignancies (215) 591-3000 San Diego, CA (908) 298-4000 stem cell therapy Teva Pharmaceuticals Schering-Plough (Orphan Drug) USA Kenilworth, NJ North Wales, PA R7112 Roche hematological Phase I TAK901 Millennium hematological Phase I Nutley, NJ malignancies (973) 235-5000 Pharmaceuticals malignancies (800) 390-5663 (see also solid tumors) Cambridge, MA recombinant Rare Disease ALL Phase I/II CytRx APL Phase II Wolinella Therapeutics (615) 399-0700 (Orphan Drug) Los Angeles, CA (310) 826-5648 succinogenes Nashville, TN Tasigna® Novartis CML (first-line therapy) Phase II nilotinib Pharmaceuticals (see also stomach) (888) 669-6682 (rWS) (Orphan Drug) East Hanover, NJ LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 13

13 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

tasisulam (ASAP) Eli Lilly AML Phase I Avastin® Genentech (see also brain, Phase II Indianapolis, IN (see also ovarian, (800) 545-5979 bevacizumab South San Francisco, colorectal, head/neck, (650) 225-1000 sarcoma, skin) CA kidney, lung, Telintra® Telik myelodysplastic Phase II lymphoma, multiple ezatiostat Palo Alto, CA syndromes (650) 845-7700 myeloma, ovarian, (see also cancer-related) pancreatic, prostate, stomach, other) Temodar® Schering-Plough AML Phase II Kenilworth, NJ (see also lung) (908) 298-4000 AZD6244 AstraZeneca biliary cancer, liver Phase II

® Wilmington, DE cancer (see also (800) 236-9933 Triapine Vion Pharmaceuticals leukemia Phase II oncology-times.com leukemia, lung, New Haven, CT (see also lung, (203) 498-4210 multiple myeloma, pancreatic, prostate) ovarian, pancreatic, hematological Phase I skin, other) malignancies (203) 498-4210 batabulin Amgen Phase III tricirbine VioQuest hematological Phase I/II Thousand Oaks, CA (805) 447-1000 (VQD-002) Pharmaceuticals malignancies (908) 766-4400 belinostat TopoTarget USA inoperable/unresectable Phase I/II Basking Ridge, NJ (see also solid tumors) Rockaway, NJ liver cancer (see also (973) 895-6900 ® Trisenox Cephalon AML in elderly patients Phase III bladder, colorectal, arsenic trioxide Frazer, PA (combination therapy) (610) 344-0200 leukemia, lung, (see also brain, multiple lymphoma, ovarian) myeloma) brivanib Bristol-Myers Squibb hepatocellular Phase III TRU-016 CLL Phase I/II (VEGFR/FGFR Princeton, NJ carcinoma (see also (212) 546-4000 Pharmaceuticals (206) 838-0500 kinase inhibitor) colorectal) Seattle, WA CRS-100 Cerus Phase I ® Vidaza Celgene AML, Phase I Concord, CA (925) 288-6000 Summit, NJ myelodysplastic (908) 673-9000 darinaparsin ZIOPHARM (see also leukemia, Phase II (Orphan Drug) syndromes (see also (ZIO-101) Oncology multiple myeloma, completed lymphoma, prostate) New York, NY solid tumors) (646) 214-0700 VP101 Access Pharmaceuticals hematological Phase II DENSPM Genzyme Phase I/II Dallas, TX malignancies (see also (214) 905-5100 (Orphan Drug) Cambridge, MA (617) 252-7500 brain, colorectal, prostate) doxorubicin Delcath Systems Phase II VP701 Virium Pharmaceuticals Phase I (percutaneous New York, NY (212) 489-2100 Princeton, NJ (609) 951-2270 hepatic perfusion) Xcytrin® Pharmacyclics CLL Phase II EHC-18 Enzo BioChem Phase I motexafin Sunnyvale, CA (see also brain, kidney, (408) 774-0330 New York, NY (212) 583-0100 gadolinium lung, lymphoma) eniluracil Adherex Technologies (see also solid tumors) Phase I/II XL-228 Exelixis ALL, CML Phase I Durham, NC (919) 484-8484 South San Francisco, (650) 837-7000 CA ferucarbotran Bayer HealthCare liver cancer imaging application Pharmaceuticals submitted Zarnestra™ Johnson & Johnson AML Phase III Wayne, NJ (888) 842-2937 Pharmaceutical (see also pancreatic) (800) 817-5286 Research & GC-33 Chugai Pharma USA Phase I Development Berkeley Heights, NJ (908) 516-1350 Raritan, NJ IMC-1121B Eli Lilly (see also breast, Phase II Zolinza® Merck AML, myelodysplastic Phase II Indianapolis, IN colorectal, kidney, (800) 545-5979 vorinostat Whitehouse Station, NJ syndromes (see also (800) 672-6372 ImClone Systems lung, ovarian, prostate, (212) 645-1405 brain, breast, colorectal, New York, NY skin) kidney, lung, IMC-A12 Eli Lilly (see also breast, Phase II lymphoma, multiple Indianapolis, IN colorectal, (800) 545-5979 myeloma) ImClone Systems head/neck, lung, (212) 645-1405 zosuquidar Kanisa Pharmaceuticals AML in elderly patients Phase I/II New York, NY pancreatic, prostate, San Diego, CA (858) 436-1800 sarcoma, solid tumors) irinotecan Biocompatibles metastatic liver cancer Phase II Liver Cancer eluting beads International from colorectal cancer www.bio Surrey, compatibles.com ABT-869 Abbott Laboratories (see also breast, Phase II United Kingdom Abbott Park, IL kidney, lung) (847) 937-6100 Genentech (650) 225-1000 JX-594 Jennerex (see also solid tumors) Phase II South San Francisco, CA Biotherapeutics (415) 281-8886 San Francisco, CA amsilarotene Taiho Pharma USA Phase I/II Princeton, NJ (609) 750-5300 Human Genome (see also lung, multiple Phase I/II Sciences myeloma) (301) 309-8504 Armala™ GlaxoSmithKline (see also brain, breast, Phase I Rockville, MD pazopanib Rsch. Triangle Park, cervical, kidney, lung, (888) 825-5249 NC ovarian, sarcoma, other) MB-7133 Metabasis Therapeutics inoperable, Phase I/II (Orphan Drug) La Jolla, CA unresectable (858) 587-2770 ARQ-197 ArQule Phase I liver cancer Woburn, MA (see also lung, pancreatic, (781) 994-0300 Daiichi Sankyo solid tumors) (973) 359-2600 drug Delcath Systems Phase III Parsippany, NJ delivery system New York, NY (212) 489-2100

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14 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

NV1020 MediGene Phase I/II aflibercept sanofi-aventis second-line NSCLC Phase III San Diego, CA (858) 586-2240 (VEGF-trap) Bridgewater, NJ (combination therapy) (800) 633-1610 patupilone Novartis (see also brain, breast, Phase II Regeneron (see also colorectal, (914) 345-7400 (EPO906) Pharmaceuticals colorectal, (888) 669-6682 Pharmaceuticals pancreatic, prostate, East Hanover, NJ lung, ovarian) Tarrytown, NY other) ® Photofrin® Axcan Pharma cholangiocarcinoma Phase II Alimta Eli Lilly NSCLC (maintenance Phase III PDT Birmingham, AL (205) 991-8085 pemetrexed Indianapolis, IN therapy) (see also breast, (800) 545-5979 head/neck, ovarian) AMG 102 Amgen SCLC Phase I/II oncology-times.com PR-104 Proacta Therapeutics (see also lung) Phase I San Diego, CA (858) 642-0386 Thousand Oaks, CA (see also brain, (805) 447-1000 SCH-58500 Schering-Plough (see also bladder, Phase I colorectal, kidney, (p53 Kenilworth, NJ head/neck, lung, (908) 298-4000 stomach) gene therapy) cancer-related) AMG 479 Amgen (see also breast, Phase II Sutent® Pfizer (see also breast, Phase III Thousand Oaks, CA colorectal, pancreatic, (805) 447-1000 sunitinib New York, NY colorectal, lung, (860) 732-5156 sarcoma) pancreatic, prostate, Amplimexon® AmpliMed (see also breast, multiple Phase I sarcoma, stomach) imexon Tucson, AZ myeloma, pancreatic, (520) 529-1000 tacatuzumab- Immunomedics Phase I prostate, skin) Y-90 Morris Plains, NJ (973) 605-8200 Celgene SCLC (second-line Phase III (IMMU-105) (Orphan Drug) Summit, NJ therapy) (908) 673-9000 Tarceva® Genentech (see also bladder, brain, Phase II ANZ-207 Anza Therapeutics mesothelioma, NSCLC Phase I erlotinib South San Francisco, breast, colorectal, (650) 224-1000 Concord, CA (see also ovarian, (925) 288-6000 CA head/neck, lung, other) (800) 572-1932 pancreatic) OSI Pharmaceuticals apomab Genentech NSCLC (combination Phase II Melville, NY South San Francisco, therapy) (see also (650) 225-1000 Thermodox™ Celsion inoperable, unresectable Phase III CA colorectal, lymphoma) LTSDEL Columbia, MD liver cancer (410) 290-5390 (see also breast) Armala™ GlaxoSmithKline NSCLC Phase II pazopanib Rsch. Triangle Park, (see also brain, breast, (888) 825-5249 Thymitaq® YM BioSciences (see also colorectal, Phase III NC cervical, kidney, liver, nolatrexed Wayne, PA head/neck, lung, (610) 560-0600 ovarian, sarcoma, other) (Orphan Drug) pancreatic, prostate) TJ9 Tsumura Phase II ARQ-197 ArQule NSCLC Phase I/II Tokyo, Japan tsumura.co.jp Woburn, MA (see also liver, (781) 994-0300 Daiichi Sankyo pancreatic, (973) 359-2600 Parsippany, NJ solid tumors) Lung Cancer AT-101 Ascenta Therapeutics NSCLC, SCLC Phase II 1572932A GlaxoSmithKline non-small-cell lung Phase III San Diego, CA (see also lymphoma, (858) 436-1200 Rsch. Triangle Park, cancer (NSCLC) (888) 825-5249 prostate) NC Abraxane™ Abraxis BioScience NSCLC Phase III AV-951 AVEO Pharmaceuticals NSCLC Phase I/II albumin-bound Los Angeles, CA (see also head/neck, (310) 883-1300 Cambridge, MA (see also kidney, (617) 299-5000 paclitaxel ovarian, pancreatic, stomach) prostate, skin) Avastin® Genentech SCLC Phase II ABT-263 Abbott Laboratories small-cell-lung cancer Phase I/II bevacizumab South San Francisco, (see also brain, (650) 225-1000 Abbott Park, IL (SCLC) (see also (847) 937-6100 CA colorectal, head/neck, Genentech leukemia, lymphoma) (650) 225-1000 kidney, liver, lymphoma, South San Francisco, multiple myeloma, CA ovarian, pancreatic, prostate, stomach, other) ABT-751 Abbott Laboratories NSCLC Phase II Abbott Park, IL (see also breast, (847) 937-6100 axitinib Pfizer NSCLC Phase II colorectal, kidney) New York, NY (first-line therapy) (860) 732-5156 ABT-869 Abbott Laboratories NSCLC Phase II (see also colorectal, Abbott Park, IL (see also breast, kidney, (847) 937-6100 kidney, solid tumors, Genentech liver) (650) 225-1000 other) South San Francisco, CA AZD6244 AstraZeneca NSCLC Phase II Actimid™ Celgene SCLC (combination Phase I/II Wilmington, DE (see also leukemia, liver, (800) 236-9933 pomalidomide Summit, NJ therapy) (see also (908) 673-9000 multiple myeloma, multiple myeloma, ovarian, pancreatic, pancreatic, prostate, skin, other) sarcoma) belinostat TopoTarget USA mesothelioma Phase II Advexin® Introgen Therapeutics NSCLC (combination Phase II Rockaway, NJ (see also bladder, (973) 895-6900 contusugene Austin, TX therapy) (see also (512) 708-9310 colorectal, leukemia, ladenovec bladder, brain, breast, liver, lymphoma, head/neck, ovarian, ovarian, stomach) prostate, stomach) BIBF 1120 Boehringer Ingelheim NSCLC Phase III bronchioloalveolar Phase I Pharmaceuticals (see also solid tumors) (800) 243-0127 adenocarcinoma (512) 708-9310 Ridgefield, CT LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 15

15 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

BIBW 2992 Boehringer Ingelheim NSCLC (second- Phase II/III GI-4000 GlobeImmune NSCLC Phase II Pharmaceuticals line therapy) (see also (800) 243-0127 Louisville, CO (see also pancreatic) (303) 625-2700 Ridgefield, CT brain, breast, head/neck) glufosfamide Threshold SCLC Phase II BMS-690514 Bristol-Myers Squibb (see also solid tumors) in clinical trials Pharmaceuticals (see also breast, (650) 474-8200 (ErbB/VEGF Princeton, NJ (212) 546-4000 Redwood City, CA pancreatic, sarcoma) receptor inhibitor) GRN-163L Geron NSCLC (combination Phase I Camptosar® Pfizer (see also cervical, application Menlo Park, CA therapy) (see also breast, (650) 473-7700 irinotecan New York, NY pancreatic, submitted leukemia, multiple prostate) (860) 732-5156 myeloma) oncology-times.com canertinib Pfizer NSCLC Phase II Hycamtin® GlaxoSmithKline NSCLC Phase III New York, NY (860) 732-5156 topotecan Rsch. Triangle Park, (see also breast, (888) 825-5249 Capoxigem® Tragara Pharmaceuticals NSCLC (combination Phase II NC colorectal, head/neck, apricoxib San Diego, CA therapy) (see also breast, (858) 350-6900 kidney, leukemia, pancreatic) lymphoma, multiple myeloma, ovarian, CBP501 Millennium mesothelioma Phase II pancreatic, prostate, Pharmaceuticals (combination therapy) (800) 390-5663 stomach, other) Cambridge, MA (see also solid tumors) HyperAcute® NewLink Genetics NSCLC Phase I/II Transave Phase II Lung Ames, IA (515) 296-5555 liposomal Monmouth Junction, NJ (732) 438-9434 lung cancer conatumumab Amgen NSCLC Phase I/II vaccine Thousand Oaks, CA (see also colorectal, (805) 447-1000 IMC-1121B Eli Lilly NSCLC Phase II pancreatic, sarcoma) Indianapolis, IN (see also breast, (800) 545-5979 CP-751871 Pfizer NSCLC Phase III ImClone Systems colorectal, kidney, liver, (212) 645-1405 New York, NY (combination therapy), (860) 732-5156 New York, NY ovarian, prostate, skin) metastatic disease IMC-A12 Eli Lilly NSCLC (combination Phase II (see also breast, colorectal, Indianapolis, IN therapy) (see also breast, (800) 545-5979 multiple myeloma, ImClone Systems colorectal, head/neck, (212) 645-1405 prostate, sarcoma) New York, NY liver, pancreatic, NSCLC (combination Phase I/II prostate, sarcoma, first-line therapy) (860) 732-5156 solid tumors) CS-1017 Daiichi Sankyo NSCLC Phase II IMGN-901 ImmunoGen SCLC Phase II Parsippany, NJ (see also other) (973) 359-2600 Cambridge, MA (see also multiple (617) 995-2500 deforolimus ARIAD Pharmaceuticals NSCLC Phase II myeloma) (MK-8669) Cambridge, MA (see also breast, prostate, (617) 494-0400 IMO-2055 Idera Pharmaceuticals NSCLC Phase I Merck sarcoma, other) (800) 672-6372 Cambridge, MA (second-line therapy) (617) 679-5500 Whitehouse Station, NJ (see also colorectal, diflomotecan Biomeasure (Ipsen) SCLC Phase II kidney) Milford, MA (508) 478-0144 INGN 225 Introgen Therapeutics SCLC Phase II DMXAA Antisoma NSCLC (first-line Phase III (p53 vaccine) Austin, TX (see also breast) (512) 708-9310 Cambridge, MA therapy) (617) 225-0522 INGN 401 Introgen Therapeutics NSCLC Phase I Novartis (see also prostate) (888) 669-6682 (nano-FUS-1) Austin, TX (512) 708-9310 Pharmaceuticals Ixempra™ Bristol-Myers Squibb NSCLC in clinical trials East Hanover, NJ ixabepilone Princeton, NJ (see also breast, (212) 546-4000 doxorubicin Zivena Phase II pancreatic, prostate) inhaled Columbus, OH (614) 340-2370 JNJ-26854165 Johnson & Johnson NSCLC Phase I EC-145 Endocyte late-stage NSCLC Phase II Pharmaceutical (see also prostate) (800) 817-5286 West Lafayette, IN (see also ovarian, other) (765) 463-7175 Research & Erbitux® Bristol-Myers Squibb advanced NSCLC, Phase III Development cetuximab Princeton, NJ locally advanced (212) 546-4000 Raritan, NJ Eli Lilly NSCLC, (800) 545-5979 Karenitecin® BioNumerik NSCLC (intravenous) Phase II Indianapolis, IN first-line, second-line (212) 645-1405 cositecan Pharmaceuticals (see also brain, ovarian, ImClone Systems (see also bladder, San Antonio, TX skin) (210) 614-1701 New York, NY colorectal, head/neck, NSCLC (oral) Phase I/II prostate, stomach) (210) 614-1701 eribulin mesylate Eisai NSCLC Phase II Levulan® PD DUSA Pharmaceuticals (see also bladder, cervical, in clinical trials (E7389) Woodcliff Lake, NJ (see also breast, (888) 422-4743 aminolevulinic Wilmington, MA colorectal, stomach) (978) 657-7500 head/neck, ovarian, acid prostate, sarcoma, ® solid tumors) Lucanix NovaRx NSCLC Phase III belagen- San Diego, CA (see also brain) (858) 552-8600 Gemzar® Eli Lilly metastatic SCLC Phase II pumatucel-L gemcitabine Indianapolis, IN (see also head/neck, (800) 545-5979 lymphoma, sarcoma) lung cancer NSCLC Phase I/II vaccine Philadelphia, PA (215) 241-9760 Genasense® Genta NSCLC Phase II/III oblimersen Berkeley Heights, NJ (see also breast, leukemia, (908) 286-9800 lung cancer Pfizer NSCLC Phase I lymphoma, skin, vaccine New York, NY (860) 732-5156 solid tumors) (NY-ESO-1)

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16 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

mapatumumab Human Genome NSCLC Phase II poliglumex Novartis stomach, other) (800) 215-2355 Sciences (see also liver, multiple (301) 309-8504 Pharmaceuticals (888) 669-6682 Rockville, MD myeloma) East Hanover, NJ milataxel Taxolog NSCLC Phase II P-2045 Antisoma NSCLC, SCLC Phase I Fairfield, NJ (see also breast, (877) 829-6564 Cambridge, MA (617) 225-0522 colorectal) patupilone Novartis NSCLC Phase II MK-0646 Merck NSCLC Phase I/II (EPO906) Pharmaceuticals (see also brain, breast, (888) 669-6682 Whitehouse Station, (see also breast, (800) 672-6372 East Hanover, NJ colorectal, NJ pancreatic, other) liver, ovarian) oncology-times.com MKC 1 EntreMed NSCLC Phase II pelitinib Wyeth Pharmaceuticals NSCLC (second- Phase II Rockville, MD (see also breast, (240) 864-2600 (EKB569) Collegeville, PA line therapy) (800) 934-5556 leukemia, pancreatic) (see also colorectal) MORAb-009 Eisai mesothelioma Phase II PF-299804 Pfizer NSCLC Phase II Woodcliff Lake, NJ (see also ovarian, (888) 422-4743 New York, NY (860) 732-5156 pancreatic) picoplatin Poniard Pharmaceuticals SCLC Phase II NSCLC Phase I (Orphan Drug) Seattle, WA (see also colorectal) (206) 281-7001 (888) 422-4743 plitidepsin PharmaMar USA SCLC Phase II motesanib Amgen NSCLC (combination Phase III Cambridge, MA (see also multiple (617) 868-3797 Thousand Oaks, therapy) (see also breast, (805) 447-1000 myeloma, prostate) CA colorectal, other)(800) 390-5663 PR-104 Proacta Therapeutics NSCLC, SCLC Phase II Millennium San Diego, CA (see also liver) (858) 642-0386 Pharmaceuticals pralatrexate Allos Therapeutics NSCLC Phase II Cambridge, MA (PDX) Westminster, CO (see also bladder, (303) 426-6262 naptumomab Active Biotech NSCLC Phase I lymphoma) estafenatox Lund, Sweden (see also kidney, completed ProMune® Pfizer NSCLC Phase II pancreatic) www.active agatolimod New York, NY (860) 732-5156 biotech.com PS-095760 Ligand Pharmaceuticals NSCLC Phase II neratinib Wyeth Pharmaceuticals NSCLC Phase II San Diego, CA (see also leukemia) (858) 550-7500 (HKI272) Collegeville, PA (see also breast) (800) 934-5556 Schering-Plough (908) 298-4000 ® Nexavar Bayer HealthCare NSCLC (combination Phase III Kenilworth, NJ sorafenib Pharmaceuticals therapy) (see also (888) 842-2837 R1454 Roche NSCLC Phase I Wayne, NJ breast, skin) (510) 597-6500 Nutley, NJ (973) 235-5000 Onyx Pharmaceuticals R1507 Roche NSCLC (combination Phase II Emeryville, CA SCLC Phase II Nutley, NJ therapy) (see also breast, (973) 235-5000 (888) 842-2837 lymphoma, sarcoma) (510) 597-6500 Reolysin® Oncolytics Biotech NSCLC Phase II NOV-002 Novelos Therapeutics NSCLC Phase III reovirus Calgary, Canada (combination therapy) (403) 670-7377 Newton, MA (combination (617) 244-1616 (see also brain, first-line therapy) head/neck, sarcoma, (see also breast, ovarian) skin) NPI-2358 Nereus NSCLC Phase I retaspimycin Infinity NSCLC Phase II Pharmaceuticals (see also lymphoma) (858) 587-4090 (IPI 504) Pharmaceuticals (see also breast, (617) 453-1000 San Diego, CA Cambridge, MA stomach) obatoclax Gemin X NSCLC, SCLC Phase I/II S-1 Taiho Pharma USA NSCLC Phase II Biotechnologies (combination therapy) (514) 281-8989 Princeton, NJ (609) 750-5300 Montreal, Canada (see also leukemia, lymphoma) salirasib Concordia NSCLC Phase II Ft. Lauderdale, FL (see also pancreatic) www.concordia OBP-301 Oncolys Biopharma mesothelioma Phase I pharma.com Tokyo, Japan (see also breast, www.oncolys. head/neck) com sapacitabine Cyclacel NSCLC Phase II Pharmaceuticals (see also leukemia, (973) 847-5955 OGX-011 Isis Pharmaceuticals NSCLC Phase I/II Short Hills, NJ lymphoma) (ISIS-112989) Carlsbad, CA (760) 931-9200 Oncogenex (425) 686-1500 satraplatin Spectrum NSCLC (combination Phase II Pharmaceuticals Pharmaceuticals therapy) (949) 788-6700 Bothell, WA Irvine, CA (see also breast, prostate) OGX-427 Oncogenex NSCLC Phase I Pharmaceuticals (see also bladder, (425) 686-1500 SCH-58500 Schering-Plough NSCLC Phase II Bothell, WA breast, ovarian, prostate) (p53 gene Kenilworth, NJ (see also bladder, (908) 298-4000 therapy) head/neck, liver, Onconase® Alfacell mesothelioma Phase III cancer-related) ranpirnase Bloomfield, NJ (combination therapy) (973) 748-8082 (Orphan Drug) Strativa SCH-727965 Schering-Plough NSCLC Phase II Pharmaceuticals Kenilworth, NJ (see also breast, (908) 298-4000 leukemia) Woodcliff Lake, NJ NSCLC Phase I/II (973) 748-8082 Cyclacel NSCLC Phase II Pharmaceuticals (see also other) (973) 847-5955 Opaxio™ Cell Therapeutics NSCLC Phase III Short Hills, NJ paclitaxel Seattle, WA (see also ovarian, LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 17

17 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

sibrotuzumab Life Science NSCLC Phase II XL-647 Exelixis NSCLC (first-line Phase II Pharmaceuticals (see also colorectal, (203) 422-6500 South San Francisco, therapy, second-line (650) 837-7000 Greenwich, CT head/neck) CA therapy) SNDX-275 Syndax NSCLC Phase I/II Zactima™ AstraZeneca NSCLC (see also Phase III Pharmaceuticals (see also breast) (781) 839-7301 vandetanib Wilmington, DE brain, breast, other) (800) 236-9933 Waltham, MA SCLC Phase II Stimuvax® EMD Serono NSCLC Phase III (800) 236-9933 BLP25 liposomal Rockland, MA (800) 283-8088 Zolinza® Merck mesothelioma Phase III cancer vaccine Oncothyreon (425) 450-0370 vorinostat Whitehouse Station, NJ (see also brain, breast, (800) 672-6372 oncology-times.com Bellevue, WA colorectal, kidney, Sutent® Pfizer NSCLC (combination Phase III leukemia, lymphoma, sunitinib New York, NY therapy, second-line (860) 732-5156 multiple myeloma) therapy) (see also breast, Zybrestat™ OXiGENE NSCLC (first-line Phase II colorectal, liver, pancreatic, fosbretabulin Waltham, MA therapy) (see also (781) 547-5900 prostate, sarcoma, stomach) head/neck, ovarian, talactoferrin Agennix NSCLC Phase III other) (Orphan Drug) Houston, TX (see also kidney) (713) 552-1091 Tarceva® Genentech NSCLC (combination Phase III Lymphoma erlotinib South San therapy) (see also (650) 225-1000 461364 GlaxoSmithKline non-Hodgkin’ I CA Francisco, bladder, brain, breast, (800) 572-1932 Rsch. Tri. Park, NC lymphoma (see also (888) 825-5249 OSI Pharmaceuticals colorectal, head/neck, solid tumors) Melville, NY liver, other) 690693 GlaxoSmithKline (see also solid tumors) Phase I Telcyta™ Telik NSCLC (third-line Phase III Rsch. Tri. Park, NC (888) 825-5249 canfosfimide Palo Alto, CA therapy) (see also (650) 845-7700 743921 Cytokinetics non-Hodgkin’s Phase I/II breast, colorectal, South San lymphoma (650) 624-3000 ovarian) Francisco, CA Temodar® Schering-Plough SCLC Phase II Hodgkin’s disease Phase I temozolomide Kenilworth, NJ (see also leukemia) (908) 298-4000 (650) 624-3000 TG-4010 Transgene Phase I 1018 ISS Dynavax Technologies non-Hodgkin’s Phase II Kensington, MD (301) 816-5404 Berkeley, CA lymphoma (see also (510) 848-5100 ® Thymitaq YM BioSciences (see also colorectal, Phase II colorectal) nolatrexed Wayne, PA head/neck, liver, (610) 560-0600 ABT-263 Abbott Laboratories (see also leukemia, Phase I/II pancreatic, prostate) Abbott Park, IL lung) (847) 937-6100 topotecan Hana Biosciences SCLC (see also Phase I Genentech (650) 225-1000 liposomal South San Francisco, ovarian (650) 588-6404 South San Francisco CA) AME-133 Applied Molecular non-Hodgkin’s Phase I/II Torisel™ Wyeth Pharmaceuticals NSCLC (see also Phase II Evolution lymphoma (858) 597-4990 temsirolimus Collegeville, PA colorectal, kidney, (800) 934-5556 San Diego, CA lymphoma, multiple AMG 951 Amgen Thousand non-Hodgkin’s Phase II myeloma, prostate) (rhApo2L/ Oaks, CA lymphoma (805) 447-1000 tremelimumab Pfizer NSCLC Phase II TRAIL) Genentech (see also colorectal) (650) 225-1000 New York, NY (see also breast, (860) 732-5156 South San Francisco, CA colorectal, kidney, apomab Genentech non-Hodgkin’s Phase II prostate, skin) South San Francisco lymphoma (650) 225-1000 ® Triapine Vion Pharmaceuticals NSCLC Phase II (combination New Haven, CT (see also leukemia, (203) 498-4210 therapy) (see also pancreatic, prostate) colorectal, lung) tucotuzumab EMD Serono NSCLC, SCLC Phase II AR-726 Antigenics non-Hodgkin’s Phase I celmoleukin Rockland, MA (see also colorectal, (800) 283-8088 New York, NY lymphoma (see also (212) 994-8200 ovarian, prostate) colorectal) Vectibix™ Amgen NSCLC Phase II AT-101 Ascenta Therapeutics non-Hodgkin’s Phase II panitumumab Thousand Oaks, CA (see also head/neck) (805) 447-1000 San Diego, CA lymphoma (see also (858) 436-1200 Velcade® Millennium NSCLC (combination Phase II lung, prostate) Pharmaceuticals therapy, metastatic (800) 390-5663 atacicept EMD Serono non-Hodgkin’s Phase I Cambridge, MA disease, monotherapy, (TACI-Ig) Rockland, MA lymphoma (see also (800) 283-8088 second-line therapy) ZymoGenetics leukemia, multiple (206) 442-6600 (see also lymphoma, Seattle, WA myeloma) multiple myeloma, solid AV-299 AVEO Pharmaceuticals (see also solid tumors) Phase I tumors) (SCH-90015) Cambridge, MA (617) 299-5000 volociximab Biogen Idec NSCLC Phase II Schering-Plough Cambridge, MA (see also ovarian, (617) 679-2000 Kenilworth, NJ Facet Biotech pancreatic, skin) (650) 454-1000 Avastin® Genentech diffuse large B-cell Phase III Redwood City, CA bevacizumab South San Francisco, lymphoma (first-line (650) 225-1000 ® Xcytrin Pharmacyclics NSCLC Phase II CA therapy) (see also brain, motexafin Sunnyvale, CA (see also brain, kidney, (408) 774-0330 colorectal, head/neck, gadolinium leukemia, lymphoma) kidney, liver, lung,

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18 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

multiple myeloma, Spectrum non-Hodgkin’s Phase II ovarian, pancreatic, Pharmaceuticals lymphoma completed prostate, stomach, Irvine, CA (949) 788-6700 other) enzastaurin Eli Lilly non-Hodgkin’s Phase III non-Hodgkin’s Phase II (LY317615) Indianapolis, IN lymphoma (see also (800) 545-5979 lymphoma (650) 225-1000 brain, breast, colorectal, AZD4877 AstraZeneca (see also leukemia) Phase I multiple myeloma, Wilmington, DE (800) 236-9933 ovarian, prostate) EZN-2968 Enzon Pharmaceuticals (see also solid tumors) Phase I oncology-times.com Immunomedics non-Hodgkin’s Phase II Morris Plains, NJ lymphoma imaging (973) 605-8200 Bridgewater, NJ (866) 792-5172 agent Fodosine™ BioCryst cutaneous T-cell Phase III belinostat TopoTarget USA peripheral T-cell Phase III forodesine Pharmaceuticals lymphoma (see also (205) 444-4600 Rockaway, NJ lymphoma (see also (973) 895-6900 Birmingham, AL leukemia) bladder, colorectal, T-cell lymphoma Phase II leukemia, liver, lung, (205) 444-4600 ovarian) fostamatinib Rigel Pharmaceuticals B-cell lymphoma, Phase II cutaneous T-cell Phase II South San Francisco, T-cell lymphoma (650) 624-1100 lymphoma, non- (973) 895-6900 CA Hodgkin’s lymphoma, GA101 Biogen Idec B-cell lymphoma, Phase II thymoma Cambridge, MA non-Hodgkin’s (617) 679-2000 Bexxar® GlaxoSmithKline (see also leukemia, Phase II Genentech South lymphoma (650) 225-1000 tositumomab Rsch. Triangle Park, cancer-related) (888) 825-5249 San Francisco, CA NC galiximab Biogen Idec non-Hodgkin’s Phase III BI 2536 Boehringer Ingelheim non-Hodgkin’s Phase I (anti-CD80 Cambridge, MA lymphoma (617) 679-2000 Pharmaceuticals lymphoma (800) 243-0127 mAb) Ridgefield, CT GCS-100 Prospect Therapeutics diffuse large B-cell Phase I/II BiovaxID™ Accentia non-Hodgkin’s Phase III Woburn, MA lymphoma (781) 939-5750 B-cell lymphoma BioPharmaceuticals lymphoma (813) 864-2554 (combination therapy) vaccine Tampa, FL (see also leukemia, CAL-101 Calistoga non-Hodgkin’s Phase I multiple myeloma) Pharmaceuticals lymphoma (206) 728-4700 Gemzar® Eli Lilly (see also head/neck, Phase II Seattle, WA (see also leukemia) gemcitabine Indianapolis, IN lung, sarcoma) (800) 545-5979 CAT-8015 MedImmune non-Hodgkin’s Phase I Genasense® Genta non-Hodgkin’s Phase II Gaithersburg, MD lymphoma (see also (301) 398-0000 oblimersen Berkeley Heights, NJ lymphoma (see also (908) 286-9800 leukemia) breast, leukemia, lung, cilengitide EMD Serono late-stage lymphoma Phase I skin, solid tumors) Rockland, MA (see also brain, (800) 283-8088 GMX-1777 Gemin X (see also skin, solid Phase I prostate, solid tumors) Biotechnologies tumors) (514) 281-8989 Clearazide™ Yaupon Therapeutics cutaneous T-cell Phase III Montreal, Canada Radnor, PA lymphoma (610) 975-9290 GS-9219 Gilead Sciences non-Hodgkin’s Phase I/II Clolar® Genzyme B-cell lymphoma, Phase I/II Foster City, CA lymphoma (see also (800) 445-3235 clofarabine Cambridge, MA non-Hodgkin’s (617) 252-7500 leukemia) lymphoma (see also Hycamtin® GlaxoSmithKline non-Hodgkin’s Phase II leukemia) topotecan Rsch. Triangle Park, lymphoma (see also (888) 825-5249 crinobulin EpiCept (see also solid tumors) Phase I NC breast, colorectal, Tarrytown, NY (914) 606-3500 head/neck, kidney, leukemia, lung, multiple CT-011 CureTech B-cell lymphoma Phase II myeloma, ovarian, Yavne, Israel www.cure pancreatic, prostate, techbio.com stomach, other) dacetuzumab Genentech diffuse large B-cell Phase II iboctadekin GlaxoSmithKline non-Hodgkin’s Phase I (anti-CD40) South San Francisco, lymphoma (see also (650) 225-1000 Rsch. Triangle Park, lymphoma (888) 825-5249 CA Seattle Genetics leukemia, multiple (425) 527-4000 NC (combination therapy) Bothell, WA myeloma) (see also ovarian) non-Hodgkin’s Phase I Idamycin® Pfizer non-Hodgkin’s Phase III lymphoma (650) 225-1000 New York, NY lymphoma (see also (860) 732-5156 (425) 527-4000 multiple myeloma) denenicokin ZymoGenetics non-Hodgkin’s Phase I inotuzumab UCB Smyrna, GA non-Hodgkin’s Phase III (IL-21) Seattle, WA lymphoma (206) 442-6600 ozogamicin Wyeth Pharmaceuticals lymphoma, (770) 970-7500 (combination therapy) Collegeville, PA (combination therapy) (800) 934-5556 (see also colorectal, kidney, ovarian, skin) Medarex Hodgkin’s disease, Phase II (MDX-060) Princeton, NJ lymphoma, non- (609) 430-2880 DI-Leu16-IL2 EMD Serono non-Hodgkin’s Phase I (Orphan Drug) Hodgkin’s lymphoma Rockland, MA lymphoma (800) 283-8088 Provenance (781) 491-9888 IT-101 Calando (see also ovarian) Phase II Biopharmaceuticals Pharmaceuticals (626) 683-7200 Waltham, MA Pasadena, CA LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 19

19 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

Leukine® Bayer HealthCare non-Hodgkin’s Phase II PD-332991 Pfizer mantle-cell lymphoma Phase I sargramostim Pharmaceuticals lymphoma (see also (888) 842-2937 New York, NY (see also breast, (860) 732-5156 Wayne, NJ leukemia, ovarian, multiple myeloma) prostate, skin) perifosine AEterna Zentaris Waldenström’s Phase II Novartis Pharmaceuticals (see also multiple Phase I/II Montreal, Canada macroglobulinemia (212) 531-5965 East Hanover, NJ myeloma) (888) 669-6682 Keryx (see also brain, head/ XOMA (510) 204-7200 Biopharmaceuticals neck, kidney, multiple Berkeley, CA New York, NY myeloma, ovarian, LY2469298 Eli Lilly Phase I sarcoma) oncology-times.com Indianapolis, IN (800) 545-5979 Cell Therapeutics non-Hodgkin’s Phase III LymphoCide® Immunomedics non-Hodgkin’s Phase II Seattle, WA lymphoma (800) 215-2355 epratuzumab Morris Plains, NJ lymphoma (see also (973) 605-8200 PM-00104 PharmaMar USA (see also solid tumors) Phase I (Orphan Drug) leukemia) Cambridge, MA (617) 868-3797 MDX-1401 Medarex Hodgkin’s disease Phase I pralatrexate Allos Therapeutics B-cell lymphoma, Phase II Princeton, NJ (609) 430-2880 (PDX) Westminster, CO peripheral T-cell (303) 426-6262 MGCD-0103 MethylGene B-cell lymphoma, Phase II (Orphan Drug) lymphoma (see also Montreal, Canada Hodgkin’s disease, (514) 337-3333 bladder, lung) non-Hodgkin’s Hodgkin’s disease, Phase I/II lymphoma (see also non-Hodgkin’s (303) 426-6262 leukemia, solid tumors) lymphoma milatuzumab Immunomedics non-Hodgkin’s Phase I/II cutaneous T-cell Phase I (IMMU-115) Morris Plains, NJ lymphoma (see also (973) 605-8200 lymphoma (303) 426-6262 leukemia, multiple PRO-131921 Genentech non-Hodgkin’s Phase I/II myeloma) South San Francisco, lymphoma (see also (650) 224-1000 MLN8237 Millennium non-Hodgkin’s Phase II CA leukemia) Pharmaceuticals lymphoma (see also brain, (800) 390-5663 PX-478 Oncothyreon (see also solid tumors) Phase I Cambridge, MA leukemia, solid tumors) Seattle, WA (206) 801-2100 ® Nipent Hospira cutaneous T-cell application R1507 Roche Hodgkin’s disease, Phase I pentostatin Lake Forest, IL lymphoma submitted Nutley, NJ non-Hodgkin’s (973) 235-5000 (Orphan Drug) (see also leukemia, (224) 212-2000 lymphoma (see also cancer-related) breast, lung, sarcoma) non-Hodgkin’s Phase II Revlimid® Celgene mantle-cell lymphoma, Phase II lymphoma (224) 212-2000 lenalidomide Summit, NJ non-Hodgkin’s (908) 673-9000 NPI-0052 (see also multiple Phase I lymphoma (see also San Diego, CA myeloma, solid tumors) (858) 587-4090 leukemia, multiple NPI-2358 Nereus Pharmaceuticals (see also lung) Phase I myeloma, prostate, San Diego, CA (858) 587-4090 other) obatoclax Gemin X , Phase II RH-1 Allos Therapeutics non-Hodgkin’s Phase I Biotechnologies Hodgkin’s disease(514) 281-8989 Westminster, CO lymphoma (see also (303) 426-6262 Montreal, Canada (see also leukemia, lung) solid tumors) mantle-cell lymphoma Phase I romidepsin Gloucester cutaneous T-cell Phase II (combination therapy) (514) 281-8989 (Orphan Drug) Pharmaceuticals lymphoma, peripheral (617) 583-1300 Cambridge, MA T-cell lymphoma (see ofatumumab GlaxoSmithKline non-Hodgkin’s Phase III also kidney, multiple Rsch. Triangle Park, lymphoma therapy) (second-line myeloma, pancreatic, NC (see also leukemia) (888) 825-5249 prostate) non-Hodgkin’s Phase II sapacitabine Cyclacel cutaneous T-cell Phase II lymphoma (first-line (888) 825-5249 Pharmaceuticals lymphoma (see also (973) 847-5955 therapy), Waldenström’s Short Hills, NJ leukemia, lung) macroglobulinemia SAR3419 sanofi-aventis non-Hodgkin’s Phase I Oncaspar® Enzon Pharmaceuticals combination therapy Phase I Bridgewater, NJ lymphoma (800) 633-1610 Bridgewater, NJ (see also solid tumors) (866) 792-5172 sardomozide Novartis non-Hodgkin’s Phase II ortatexal Spectrum non-Hodgkin’s Phase II Pharmaceuticals lymphoma (see also (888) 669-6682 Pharmaceuticals lymphoma (949) 788-6700 East Hanover, NJ solid tumors) Irvine, CA (see also kidney) SB-1518 S*Bio (see also leukemia) Phase I P276 Piramal Life Sciences mantle-cell lymphoma Phase II Redwood City, CA (650) 730-2860 Mumbai, India (see also multiple myeloma) SCH-900776 Schering-Plough (see also solid tumors) Phase I Kenilworth, NJ (908) 298-4000 panobinostat Novartis cutaneous T-cell Phase II/III Pharmaceuticals East lymphoma (see also (888) 669-6682 SGN-30 Seattle Genetics cutaneous T-cell Phase II Hanover, NJ brain, breast, leukemia, (Orphan Drug) Bothell, WA lymphoma, Hodgkin’s (425) 527-4000 prostate) disease Hodgkin’s disease Phase II SGN-35 Seattle Genetics Hodgkin’s disease Phase II (888) 669-6682 (Orphan Drug) Bothell, WA (see also leukemia) (425) 527-4000 PCI-32765 Pharmacyclics B-cell lymphoma Phase I SNS-032 Sunesis B-cell lymphoma Phase I Sunnyvale, CA (408) 774-0330 Pharmaceuticals (see also solid tumors) (650) 266-3500 South San Francisco

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20 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

stem cell Benitec AIDS-related Phase I ATN-224 Attenuon (see also prostate, skin) Phase I/II therapy Melbourne, Australia lymphoma San Diego, CA (858) 558-4111 City of Hope AUY922 Novartis (see also solid tumors) Phase I/II Medical Center Pharmaceuticals (888) 669-6682 Duarte, CA East Hanover, NJ TG-1042 Transgene cutaneous B-cell Phase II Avastin® Genentech combination therapy Phase II Kensington, MD lymphoma (301) 816-5404 bevacizumab South San Francisco, (see also brain, colorectal, (650) 225-1000 TNX-650 Genentech refractory metastatic Phase I/II CA head/neck, kidney, South San Francisco, Hodgkin’s disease (650) 225-1000 liver, lung, lymphoma, oncology-times.com CA ovarian, pancreatic, Torisel™ Wyeth Pharmaceuticals mantle-cell lymphoma Phase III prostate, stomach, other) temsirolimus Collegeville, PA (see also colorectal, (800) 934-5556 AZD6244 AstraZeneca (see also leukemia, Phase II kidney, lung, Wilmington, DE liver, lung, ovarian, (800) 236-9933 multiple myeloma, pancreatic, skin, other) prostate) BIW 8962 BioWa Phase I/II UNBS-5162 Drais Pharmaceuticals (see also solid tumors) Phase I Princeton, NJ (609) 734-3420 Bridgewater, NJ (908) 895-1200 carfilzomib Proteolix monotherapy Phase II Velcade® Millennium non-Hodgkin’s Phase III (Orphan Drug) South San Francisco, (see also leukemia, (650) 615-7550 bortezomib Pharmaceuticals lymphoma (see also (800) 390-5663 CA solid tumors) Cambridge, MA lung, multiple combination therapy Phase I myeloma, solid tumors) (650) 615-7550 Immunomedics non-Hodgkin’s Phase I/II CEP-18770 Cephalon Phase I (IMMU-106) Morris Plains, NJ lymphoma (see also (973) 605-8200 Frazer, PA (610) 344-0200 cancer-related) CP-751871 Pfizer (see also breast, Phase I ® Vidaza Celgene (see also leukemia, Phase I New York, NY colorectal, lung, completed azacitidine Summit, NJ prostate) (908) 673-9000 prostate, sarcoma) (860) 732-5156 Hana Biosciences non-Hodgkin’s Phase I CX-4945 Cylene (see also solid tumors, Phase I liposomal South San Francisco, lymphoma (see also (650) 588-6404 Pharmaceuticals other) (858) 875-5100 CA solid tumors) San Diego, CA ® Xcytrin Pharmacyclics lymphoma, non- Phase II dacetuzumab Genentech (see also leukemia, Phase I motexafin Sunnyvale, CA Hodgkin’s lymphoma (408) 774-0330 (anti-CD40) South San Francisco, lymphoma) (650) 225-1000 gadolinium (see also brain, kidney, (Orphan Drug) CA (425) 527-4000 leukemia, lung) Seattle Genetics XmAb 2513 Xencor Hodgkin’s disease, Phase I Bothell, WA Monrovia, CA T-cell lymphoma (626) 305-5900 darinaparsin Ziopharm Oncology (see also leukemia, liver, Phase II YM-155 US refractory, metastatic Phase II (ZIO-101) New York, NY solid tumors) (646) 214-0700 Deerfield, IL diffuse large B-cell (800) 727-7003 denosumab Amgen (see also cancer-related, Phase III lymphoma (see also (AMG 162) Thousand Oaks, CA other) (805) 447-1000 prostate) Bristol-Myers Squibb Phase I ZEN-012 AEterna Zentaris (see also solid tumors) Phase I Princeton, NJ (212) 546-4000 Warren, NJ (908) 626-5428 Facet Biotech (650) 454-1000 Zevalin® Spectrum non-Hodgkin’s application Redwood City, CA ibritumomab Pharmaceuticals lymphoma (first-line submitted ENMD-2076 EntreMed (see also solid tumors) Phase I tiuxetan Irvine, CA therapy) (949) 788-6700 Rockville, MD (240) 864-2600 ® Zolinza Merck B-cell lymphoma, Phase II enzastaurin Eli Lilly (see also brain, breast, Phase II vorinostat Whitehouse Station, lymphoma (see also (800) 672-6372 (LY317615) Indianapolis, IN colorectal, lymphoma, (800) 545-5979 NJ brain, breast, colorectal, ovarian, prostate) kidney, leukemia, lung, GCS-100 Prospect Therapeutics (see also leukemia, Phase I multiple myeloma) Woburn, MA lymphoma) (781) 939-5750 Multiple Myeloma GRN-163L Geron Menlo Park, CA (see also breast, Phase I leukemia, lung) (650) 473-7700 Actimid™ Celgene (see also lung, pancreatic, Phase I/II Hycamtin® GlaxoSmithKline (see also breast, in clinical trials pomalidomide Summit, NJ prostate, sarcoma) (908) 673-9000 topotecan Rsch. Triangle Park, colorectal, head/neck, (888) 825-5249 Amplimexon® AmpliMed (see also breast, lung, Phase I/II NC kidney, leukemia, lung, imexon Tucson, AZ pancreatic, prostate, completed lymphoma, ovarian, skin) (520) 529-1000 pancreatic, prostate, anti-MUC1 mAb Paladin Labs (see also breast, Phase I stomach, other) St. Laurent, Canada pancreatic) completed Idamycin® Pfizer New York, NY (see also lymphoma) Phase III (888) 376-7830 idarubicin (860) 732-5156 Aredia® Novartis (see also cancer-related) Phase II IMGN-901 ImmunoGen (see also lung) Phase I pamidronic acid Pharmaceuticals (888) 669-6682 Cambridge, MA (617) 995-2500 East Hanover, NJ INCB-18424 Incyte (see also prostate) Phase II atacicept EMD Serono (see also leukemia, Phase II Wilmington, DE (302) 498-6700 (TACI-Ig) Rockland, MA lymphoma) (800) 283-8088 IPH-2101 Innate Pharma Phase I ZymoGenetics (206) 442-6600 Marseille, France innate-pharma. Seattle, WA com LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 21

21 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

KRX-0402 Keryx (see also brain, colorectal, Phase II Zolinza® Merck (see also brain, breast, Phase III Biopharmaceuticals kidney, sarcoma) (212) 531-5965 Whitehouse Station, NJ colorectal, vorinostat (800) 672-6372 New York, NY kidney, leukemia, lung, lestaurtinib Cephalon (see also leukemia) Phase II lymphoma) Frazer, PA (610) 344-0200 ZRx101 ZelleRx (see also kidney, skin, Phase I lucatumumab Novartis (see also lymphoma) Phase I Chicago, IL cancer-related) (312) 243-5200 Pharmaceuticals (888) 669-6682 East Hanover, NJ (510) 204-7200 Ovarian Cancer Xoma, Berkeley, CA ° A6 Angstrom (see also other) Phase II oncology-times.com LY2127399 Eli Lilly Indianapolis, IN Phase II Pharmaceuticals Solana (858) 314-2356 (800) 545-5979 Beach, CA mapatumumab Human Genome (see also liver, lung) Phase II Menarini Phase II/III Sciences Rockville, MD (301) 309-8504 (anti-idiotype Florence, Italy www.mena milatuzumab Immunomedics (see also leukemia, Phase I/II ovarian cancer rini.com (IMMU-115) Morris Plains, NJ lymphoma) (973) 605-8200 vaccine) natalizumab Biogen Idec Phase I/II Abraxane™ Abraxis BioScience (see also head/neck, Phase II Cambridge, MA (617) 679-2000 albumin-bound Los Angeles, CA lung, pancreatic, (310) 883-1300 paclitaxel prostate, skin) noscapine Cougar Phase I/II ® Los Angeles, CA (310) 943-8040 Advexin Introgen Therapeutics (see also bladder, brain, Phase I contusugene Austin, TX breast, head/neck, lung, (512) 708-9310 NPI-0052 Nereus Pharmaceuticals (see also lymphoma, Phase I ladenovec prostate, stomach) San Diego, CA solid tumors) (858) 587-4090 AE-37 Antigen Express combination therapy Phase I P276 Piramal Life Sciences (see also lymphoma) Phase I Worcester, MA (see also breast) (508) 852-8783 Mumbai, India AG-14699 Pfizer (see also breast) Phase II PD-332991 Pfizer combination therapy Phase I/II New York, NY (860) 732-5156 New York, NY (see also breast, (860) 732-5156 lymphoma) AGS-8M4 Agensys Phase I Santa Monica, CA (310) 820-8029 perifosine AEterna Zentaris (see also brain, head/ Phase II Astellas Pharma US (800) 477-6472 Montreal, Canada neck, kidney, lymphoma, (212) 531-5965 Deerfield, IL Keryx ovarian, sarcoma) ® Biopharmaceuticals Alimta Eli Lilly (see also breast, head/ Phase II New York, NY pemetrexed Indianapolis, IN neck, lung) (800) 545-5979 plitidepsin PharmaMar USA (see also lung, prostate) Phase II AMG 386 Amgen (see also breast, kidney, Phase II (Orphan Drug) Cambridge, MA (617) 868-3797 Thousand Oaks, CA stomach, other) (805) 447-1000 Quadramet® Cytogen (see also prostate, Phase I/II ANZ-207 Anza Therapeutics (see also lung, Phase I samarium sm-153 Princeton, NJ sarcoma, other) (800) 833-3533 Concord, CA pancreatic) (925) 288-6000 lexidronam Armala™ GlaxoSmithKline (see also brain, breast, Phase II injection pazopanib Rsch. Triangle Park, NC cervical, kidney, liver, (888) 825-5249 Revlimid® Celgene newly-diagnosed Phase III lung, sarcoma, other) lenalidomide Summit, NJ multiple myeloma (908) 673-9000 Avastin® Genentech (see also brain, Phase III (see also leukemia, bevacizumab South San Francisco, CA colorectal, head/neck, (650) 225-1000 lymphoma, prostate, kidney, liver, lung, other) lymphoma, multiple romidepsin Gloucester (see also kidney, Phase II myeloma, pancreatic, Pharmaceuticals lymphoma, (617) 583-1300 prostate, stomach, Cambridge, MA pancreatic, prostate) other) SF1126 Semafore (see also solid tumors) Phase I AZD2281 AstraZeneca (see also breast) Phase II Pharmaceuticals (317) 876-3075 Wilmington, DE (800) 236-9933 Indianapolis, IN AZD6244 AstraZeneca (see also leukemia, Phase II tanespimycin Bristol-Myers Squibb (see also solid tumors) Phase III Wilmington, DE liver, lung, multiple (800) 236-9933 (Hsp90 inhibitor) Princeton, NJ (212) 546-4000 myeloma, pancreatic, skin, other) Torisel™ Wyeth Pharmaceuticals (see also colorectal, Phase I/II temsirolimus Collegeville, PA kidney, lung, (800) 934-5556 belinostat TopoTarget USA (see also bladder, Phase II lymphoma, prostate) Rockaway, NJ colorectal, leukemia, (973) 895-6900 liver, lung, lymphoma) Treanda® Cephalon Phase II Frazer, PA (610) 344-0200 BMS-753493 Bristol-Myers Squibb in clinical trials (- Princeton, NJ (212) 546-4000 Trisenox® Cephalon combination therapy Phase II folate) arsenic trioxide Frazer, PA (see also brain, (610) 344-0200 leukemia) BSI-201 BiPar Sciences combination and Phase II Brisbane, CA monotherapy (see also (650) 635-6050 VEL-0230 Velcura Therapeutics Phase I brain, breast, other) Ann Arbor, MI completed (734) 973-1000 Fresenius Biotech (see also other) Phase II North America www.fresenius- Velcade® Millennium previously untreated Phase III Waltham, MA biotech.com bortezomib Pharmaceuticals multiple myeloma (800) 390-5663 (subcutaneous) Cambridge, MA (see also lung, lymphoma, CDX-1307 Celldex Therapeutics (see also bladder, Phase I solid tumors) Needham, MA breast, colorectal, (781) 433-0771 pancreatic)

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22 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

D4064A Genentech (see also other) Phase I NKTR-102 Nektar Therapeutics metastatic ovarian Phase II South San Francisco, (650) 224-1000 San Carlos, CA cancer (second-line (650) 631-3100 CA therapy) (see also DCVax®-L Northwest Phase I/II colorectal) ovarian cancer Biotherapeutics (425) 608-3000 NOV-002 Novelos Therapeutics combination therapy Phase II vaccine Bothell, WA Newton, MA (see also breast, lung) completed denenicokin ZymoGenetics (see also colorectal, Phase I/II (617) 244-1616 (IL-21) Seattle, WA kidney, lymphoma, (206) 442-6600 oglufanide Implicit Bioscience Phase II skin) Woodside, CA (650) 851-3133 oncology-times.com EC-145 Endocyte (see also lung, other) Phase II OGX-427 Oncogenex (see also bladder, Phase I West Lafayette, IN (765) 463-7175 Pharmaceuticals breast, lung, prostate) (425) 686-1500 EGEN 001 Expression Genetics recurrent ovarian Phase I Bothell, WA (Orphan Drug) Huntsville, AL cancer (combination (256) 512-0077 Opaxio™ Cell Therapeutics (see also lung, Phase III therapy) paclitaxel Seattle, WA stomach, other) (800) 215-2355 Elacyt™ Clavis Pharma (see also leukemia, skin) Phase II poliglumex Novartis (888) 669-6682 elacytarabine Oslo, Norway www.clavis Pharmaceuticals pharma.com East Hanover, NJ ® enzastaurin Eli Lilly combination therapy Phase II OvaRex Paladin Labs Phase III (LY317615) Indianapolis, IN (see also brain, breast, (800) 545-5979 St. Laurent, Canada (514) 340-1112 colorectal, lymphoma, OVax® AVAX Technologies Phase I/II multiple myeloma, ovarian cancer Philadelphia, PA (215) 241-9760 prostate) vaccine eribulin Eisai (see also breast, head/ Phase II (Orphan Drug) mesylate Woodcliff Lake, NJ neck, lung, prostate, (888) 422-4743 patupilone Novartis (see also brain, breast, Phase III (E7389) sarcoma, solid tumors) (EPO906) Pharmaceuticals colorectal, liver, lung) (888) 669-6682 Eisai Phase II/III East Hanover, NJ (MORAb-003) Woodcliff Lake, NJ (888) 422-4743 perifosine AEterna Zentaris (see also brain, head/ Phase I Herceptin® Genentech (see also colorectal, Phase II Montreal, Canada neck, kidney, (212) 531-5965 trastuzumab South San Francisco, pancreatic, prostate, (650) 225-1000 Keryx lymphoma, multiple CA stomach, other) Biopharmaceuticals myeloma, sarcoma) New York, NY Hycamtin® GlaxoSmithKline (see also breast, Phase III topotecan Rsch. Triangle Park, colorectal, head/neck, (888) 825-5249 pertuzumab Genentech (see also breast) Phase II (oral) NC kidney, leukemia, lung, South San Francisco, completed lymphoma, multiple CA (650) 225-1000 myeloma, pancreatic, plevitrexed BTG International Phase II prostate, stomach, other) (BGC 9331) West Conshohocken, (610) 278-1660 iboctadekin GlaxoSmithKline combination therapy Phase I (Orphan Drug) PA Rsch. Triangle Park, (see also lymphoma) (888) 825-5249 Quinamed® ChemGenex (see also breast, Phase II NC amonafide Pharmaceuticals prostate) (650) 474-9800 idronoxil Marshall Edwards combination therapy Phase III Menlo Park, CA North Ryde, Australia (see also prostate, other) sagopilone Bayer HealthCare combination therapy Phase I/II IMC-1121B Eli Lilly (see also breast, Phase II Pharmaceuticals (see also brain, breast, (888) 842-2937 Indianapolis, IN colorectal, kidney, (800) 545-5979 Wayne, NJ prostate) ImClone Systems liver, lung, prostate, (212) 645-1405 SNS-595 Sunesis (see also leukemia) Phase II New York, NY skin) Pharmaceuticals (650) 266-3500 IMT-1012 ImmunoVaccine (see also breast) Phase I South San Francisco, CA Technologies (902) 492-1819 systemic Genentech (see also brain, Phase II Halifax, Canada hedgehog South San Francisco, colorectal, skin) (650) 224-1000 IT-101 Calando (see also lymphoma) Phase II antagonist CA Pharmaceuticals (626) 683-7200 tasisulam Eli Lilly (see also leukemia, Phase II Pasadena, CA (ASAP) Indianapolis, IN sarcoma, skin) (800) 545-5979 Karenitecin® BioNumerik (see also brain, lung, Phase III Telcyta™ Telik (see also breast, Phase III cositecan Pharmaceuticals skin) (210) 614-1701 canfosfimide Palo Alto, CA colorectal, lung) (650) 845-7700 San Antonio, TX topotecan Hana Biosciences (see also lung) Phase I lapuleucel-T Dendreon (see also breast, Phase I liposomal South San Francisco, (650) 588-6404 Seattle, WA colorectal) completed CA (206) 256-4545 tucotuzumab EMD Serono (see also colorectal, Phase II Leukine® Bayer HealthCare (see also leukemia, Phase II celmoleukin Rockland, MA lung, prostate) (800) 283-8088 sargramostim Pharmaceuticals lymphoma, prostate, (888) 842-2937 volociximab Biogen Idec (see also lung, Phase II Wayne, NJ skin) Cambridge, MA pancreatic, skin) (617) 679-2000 MK-4827 Merck Phase I Facet Biotech (650) 454-1000 Whitehouse Station, (800) 672-6372 Redwood City, CA NJ Yondelis® Johnson & Johnson combination therapy, application MORAb-009 Eisai (see also lung, Phase I trabectedin Pharmaceutical Research second-line therapy submitted Woodcliff Lake, pancreatic) (888) 422-4743 (Orphan Drug) & Development (see also breast, (800) 817-5286 NJ Raritan, NJ prostate, sarcoma, other) LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 23

23 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

Zybrestat™ OXiGENE (see also head/neck, Phase II everolimus Novartis (see also kidney, other) Phase II fosbretabulin Waltham, MA lung, other) (781) 547-5900 Pharmaceuticals (888) 669-6682 (Orphan Drug) East Hanover, NJ ZYC300 Eisai (see also breast, Phase I FG-3019 Fibrogen combination therapy Phase I Woodcliff Lake, NJ colorectal, kidney, (888) 422-4743 San Francisco, CA (415) 978-1200 prostate) GI-4000 GlobeImmune combination therapy Phase II Louisville, CO (see also lung) (303) 625-2700 glufosfamide Threshold (see also breast, lung, Phase III

Abraxane™ Abraxis BioScience (see also head/neck, Phase I/II (Orphan Drug) Pharmaceuticals sarcoma) (650) 474-8200 oncology-times.com albumin-bound Los Angeles, CA lung, ovarian, (310) 883-1300 Redwood City, CA paclitaxel prostate, skin) Herceptin® Genentech (see also colorectal, Phase II Actimid™ Celgene combination therapy Phase I/II trastuzumab South San Francisco, ovarian, prostate, (650) 225-1000 pomalidomide Summit, NJ (see also lung, multiple (908) 673-9000 CA stomach, other) myeloma, prostate, Hycamtin® GlaxoSmithKline (see also breast, Phase II sarcoma) topotecan Rsch. Triangle Park, colorectal, head/neck, (888) 825-5249 aflibercept sanofi-aventis first-line metastatic Phase III NC kidney, leukemia, (VEGF-trap) Bridgewater, NJ pancreatic cancer (800) 633-1810 lung, lymphoma, Regeneron (combination therapy) (914) 345-7400 multiple myeloma, Pharmaceuticals (see also colorectal, lung, ovarian, prostate, Tarrytown, NY prostate, other) stomach, other) AMG 479 Amgen (see also breast, Phase I/II HyperAcute® NewLink Genetics Phase II Thousand Oaks, CA colorectal, lung, (805) 447-1000 Pancreas Ames, IA (515) 296-5555 sarcoma) pancreatric Amplimexon® AmpliMed (see also breast, lung, Phase II cancer vaccine imexon Tucson, AZ multiple myeloma, (520) 529-1000 IMC-A12 Eli Lilly first-line combination Phase I/II prostate, skin) Indianapolis, IN therapy (see also (800) 545-5979 anti-MUC1 Paladin Labs (see also breast, Phase I ImClone Systems breast, colorectal, (212) 645-1405 mAb St. Laurent, Canada multiple myeloma) completed New York, NY head/neck, liver, (888) 376-7830 lung, prostate, sarcoma, solid tumors) ANZ-207 Anza Therapeutics (see also lung, ovarian) Phase I Concord, CA (925) 288-6000 Ixempra™ Bristol-Myers Squibb (see also breast, lung, in clinical trials ixabepilone Princeton, NJ prostate) (212) 546-4000 ARQ-197 ArQule (see also liver, lung, Phase I/II Woburn, MA solid tumors) (781) 994-0300 larotaxel sanofi-aventis (see also bladder) Phase III Daiichi Sankyo (973) 359-2600 (XRP9881) Bridgewater, NJ (800) 633-1610 Parsippany, NJ masitinib AB Science USA (see also leukemia, Phase III ARQ-501 ArQule combination therapy, Phase II Short Hills, NJ stomach) (973) 218-2437 (beta lapachone) Woburn, MA inoperable/ unresectable (781) 994-0300 MK-0646 Merck (see also breast, lung, Phase I/II pancreatic cancer Whitehouse Station, other) (888) 669-6682 (see also head/neck, NJ solid tumors, other) MKC 1 EntreMed (see also breast, Phase II Avastin® Genentech combination first-line Phase III Rockville, MD leukemia, lung) (240) 864-2600 bevacizumab South San Francisco, therapy (see also brain, (650) 225-1000 MORAb-009 Eisai (see also lung, ovarian) Phase II CA colorectal, head/neck, Woodcliff Lake, (888) 422-4743 kidney, liver, lung, NJ lymphoma, multiple naptumomab Active Biotech (see also kidney, lung) Phase I myeloma, ovarian, estafenatox Lund, Sweden completed prostate, stomach, other) www.active pancreatic cancer Phase II biotech.com (650) 225-1000 OncoGel™ Protherics (see also brain, Phase II AVN-944 Avalon Pharmaceuticals combination therapy Phase II Brentwood, TN stomach) (615) 327-1027 Germantown, MD (see also leukemia) (301) 556-9900 Oncophage® Antigenics (see also brain, Phase I/II AZD6244 AstraZeneca (see also leukemia, Phase II vitespen New York, NY colorectal, kidney, (866) 805-8994 Wilmington, DE liver, lung, multiple (800) 236-9933 skin, stomach) myeloma, ovarian, OncoVEX BioVex (see also skin) Phase I skin, other) GM-CSF Woburn, MA (781) 376-4900 Camptosar® Pfizer (see also cervical, lung, Phase III PancAtak™ Advantagene Phase I irinotecan New York, NY prostate) (860) 732-5156 gene therapy Boston, MA (617) 916-5445 ® Capoxigem Tragara combination therapy Phase II San Diego, CA (760) 943-8981 apricoxib Pharmaceuticals (see also breast, lung) (858) 350-6900 PN401 Wellstat Therapeutics (see also colorectal, Phase III San Diego, CA Gaithersburg, MD stomach) (240) 631-2500 CDX-1307 Celldex Therapeutics (see also bladder, Phase I PX-12 Oncothyreon (see also stomach, Phase II Needham, MA breast, colorectal, (781) 433-0771 Seattle, WA other) (206) 801-2100 ovarian) RAV-12 Raven Biotechnologies combination therapy Phase II conatumumab Amgen (see also colorectal, Phase I/II South San Francisco, (see also other) (650) 624-2600 Thousand Oaks, lung, sarcoma) (805) 447-1000 CA CA

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24 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Rexin-G™ Epeius Biotechnologies recurrent, refractory Phase I/II Actimid™ Celgene (see also lung, Phase II tumor-targeted San Marino, CA metastatic pancreatic (626) 441-6695 pomalidomide Summit, NJ multiple myeloma, (908) 673-9000 gene therapy cancer (see also breast, pancreatic, sarcoma) (Orphan Drug) sarcoma) Advexin® Introgen Therapeutics (see also bladder, Phase I romidepsin Gloucester (see also kidney, Phase I/II contusugene Austin, TX brain, breast, head/ (512) 708-9310 Pharmaceuticals lymphoma, multiple (617) 583-1300 ladenovec neck, lung, ovarian, Cambridge, MA myeloma, prostate) stomach) RP-101 SciClone Phase II aflibercept sanofi-aventis first-line metastatic Phase III (Orphan Drug) Pharmaceuticals (650) 358-3456 (VEGF-trap) Bridgewater, NJ (800) 633-1610 oncology-times.com Foster City, CA Regeneron (combination therapy) (714) 345-7400 RTA-402 Reata Pharmaceuticals combination therapy Phase I/II Pharmaceuticals (see also colorectal, lung, Dallas, TX (see also leukemia) (972) 865-2200 Tarrytown, NY pancreatic, other) salirasib Concordia (see also lung) Phase I/II AGS-1C4D4 Agensys Phase I (Orphan Drug) Pharmaceuticals www.concor Santa Monica, CA completed Ft. Lauderdale, FL diapharma.com Astellas Pharma US (310) 820-8029 Deerfield, IL (800) 477-6472 Sarasar™ Schering-Plough (see also breast, Phase II ® lonafarnib Kenilworth, NJ leukemia) (908) 298-4000 Amplimexon AmpliMed (see also breast, lung, Phase I imexon Tucson, AZ multiple myeloma, (520) 529-1000 Sutent® Pfizer (see also breast, Phase III pancreatic, skin) sunitinib New York, NY colorectal, liver, lung, (860) 732-5156 prostate, sarcoma, anti-idiotype Onyvax Phase II stomach) cancer vaccine London, England www.ony 105AD7 vax.com Thymitaq® YM BioSciences (see also colorectal, Phase II nolatrexed Wayne, PA head/neck, liver, (610) 560-0600 AT-101 Ascenta Therapeutics (see also lung, Phase II lung, prostate) San Diego, CA lymphoma) (858) 436-1200 Daiichi Sankyo Phase II ATN-224 Attenuon (see also multiple Phase II Parsippany, NJ (973) 359-2600 San Diego, CA myeloma, skin) (858) 558-4111 ® TNFerade™ GenVec (see also colorectal, Phase III Avastin Genentech (see also brain, Phase III Gaithersburg, MD head/neck, skin, (240) 632-0740 bevacizumab South San Francisco, CA colorectal, head/neck, (650) 225-1000 stomach) kidney, liver, lung, lymphoma, multiple TPI-287 Tapestry (see also prostate) Phase II myeloma, ovarian, Pharmaceuticals (303) 516-8500 pancreatic, stomach, Boulder, CO other) Triapine® Vion Pharmaceuticals (see also leukemia, Phase II Avodart® GlaxoSmithKline prostate cancer Phase III New Haven, CT lung, prostate) (203) 498-4210 dutasteride Rsch. Triangle Park, NC prevention, prostatic (888) 825-5249 ® Virulizin Lorus Therapeutics Phase III intraepithelial Toronto, Canada (416) 798-1200 neoplasia volociximab Biogen Idec (see also lung, ovarian, Phase II AZD4054 AstraZeneca hormone-refractory, Phase III Cambridge, MA skin) (617) 679-2000 Wilmington, DE metastatic prostate (800) 236-9933 Facet Biotech (650) 454-1000 cancer Redwood City, CA BMS-641988 Bristol-Myers Squibb Phase I Y-90 hPAM4 Immunomedics metastatic pancreatic Phase I/II ( Princeton, NJ (212) 546-4000 (IMMU-107) Morris Plains, NJ cancer (973) 605-8200 receptor (Orphan Drug) antagonist) Zarnestra™ Johnson & Johnson (see also leukemia) Phase III sanofi-aventis Phase III tipifarnib Pharmaceutical (800) 817-5286 (XRP6258) Bridgewater, NJ (800) 633-1610 Research & Camptosar® Pfizer (see also cervical, Phase II Development irinotecan New York, NY lung, pancreatic) (860) 732-5156 Raritan, NJ Celebrex® Pfizer (see also bladder) Phase II Prostate Cancer celecoxib New York, NY (860) 732-5156 cilengitide EMD Serono (see also brain, Phase II ABI-008 Abraxis BioScience hormone-refractory Phase I/II Rockland, MA lymphoma, solid (800) 283-8088 Los Angeles, CA prostate cancer (310) 883-1300 tumors) (see also breast) CNTO 95 Centocor (see also skin, solid Phase II abiraterone Cougar Biotechnology combination therapy, Phase III Horsham, PA tumors) completed Los Angeles, CA second-line therapy (310) 943-8040 (610) 651-6000 (CB7630) CNTO 328 Centocor hormone-refractory Phase II ABR-215050 Active Biotech Phase II Horsham, PA prostate cancer (610) 651-6000 Lund, Sweden www.active (see also kidney) biotech.com CP-751871 Pfizer combination therapy Phase II Abraxane™ Abraxis BioScience (see also head/neck, Phase II New York, NY (see also breast, (860) 732-5156 albumin-bound Los Angeles, CA lung, ovarian, (310) 883-1300 colorectal, lung, paclitaxel pancreatic, skin) multiple myeloma, ® Acapodene GTx prostatic intraepithelial Phase III sarcoma) toremifene Memphis, TN neoplasia (prevention) (901) 523-9700 CYT-500 Cytogen Phase I (see also cancer-related) Princeton, NJ (800) 833-3533 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 25

25 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

deforolimus ARIAD (see also breast, lung, Phase II Ixempra™ Bristol-Myers Squibb (see also breast, lung, in clinical trials (MK-8669) Pharmaceuticals sarcoma, other) (617) 494-0400 ixabepilone Princeton, NJ pancreatic) (212) 546-4000 Cambridge, MA (800) 672-6372 JNJ-26854165 Johnson & Johnson (see also lung) Phase I Merck Pharmaceutical (800) 817-5286 Whitehouse Station, NJ Research & Development DMXAA Antisoma (see also lung) Phase II Raritan, NJ Cambridge, MA completed Leukine® Bayer HealthCare (see also leukemia, Phase II Novartis (617) 225-0522 sargramostim Pharmaceuticals lymphoma, ovarian, (888) 842-2937 Pharmaceuticals (888) 669-6682 Wayne, NJ skin) East Hanover, NJ oncology-times.com Leupron Abbott Phase III enzastaurin Eli Lilly (see also brain, breast, Phase II Depot® Pharmaceuticals (847) 937-6100 (LY317615) Indianapolis, IN colorectal, lymphoma, (800) 545-5979 Abbott Park, IL multiple myeloma, depot (6-month ovarian) formulation) ® Erbitux Bristol-Myers Squibb (see also bladder, Phase III leuprorelin Enzon Pharmaceuticals Phase I cetuximab Princeton, NJ colorectal, head/neck, (212) 546-4000 inhalation Bridgewater, NJ (908) 541-8600 lung, stomach) Nektar Therapeutics 650) 631-3100 Eli Lilly (800) 545-5979 San Carlos, CA Indianapolis, IN (212) 645-1405 MCS110 Novartis Pharmaceuticals (see also other) Phase I/II ImClone Systems East Hanover, NJ (888) 669-6682 New York, NY MDV-3100 Medivation hormone-refractory Phase I/II eribulin Eisai hormone-refractory Phase II San Francisco prostate cancer (415) 543-3470 mesylate Woodcliff Lake, NJ prostate cancer, (888) 422-4743 (E7389) prostate cancer mepacrine BioLabs Phase II (see also breast, head/ Buffalo, NY (716) 849-6810 neck, lung, ovarian, MER-104 Merrion Phase I/II sarcoma, solid tumors) Pharmaceuticals (910) 799-1847 Gleevec® Novartis (see also leukemia) Phase II/III Wilmington, NC imatinib Pharmaceuticals East (888) 669-6682 MIP1072 Molecular Insight diagnosis of prostate Phase I Hanover, NJ Pharmaceuticals cancer (617) 492-5554 GRNVAC1 Argos Therapeutics (see also leukemia) Phase I/II Cambridge, MA Durham, NC (919) 287-6300 MIP1095 Molecular Insight diagnosis of prostate Phase I Geron (650) 473-7700 Pharmaceuticals cancer (617) 492-5554 Menlo Park, CA Cambridge, MA GTx-758 GTx Phase I MK-0429 Merck Whitehouse Phase I Memphis, TN (901) 523-9700 Station, NJ (800) 672-6372 HE-3235 Hollis-Eden late-stage prostate Phase I/II MVA-BN®- BN Immuno Phase I/II Pharmaceuticals cancer (858) 587-9333 PRO Therapeutics (650) 681-4660 San Diego, CA Mountain View, CA Herceptin® Genentech (see also colorectal, Phase II NBI-42902 Neurocrine Biosciences (see also breast, other) Phase I trastuzumab South San Francisco, ovarian, stomach, pancreatic, San Diego, CA (858) 617-7600 CA other) (650) 225-1000 NeuVaxTM Apthera (see also breast) Phase I/II Hycamtin® GlaxoSmithKline (see also breast, Phase II E75 cancer Scottsdale, AZ (480) 882-8841 topotecan Rsch. Triangle Park, colorectal, head/neck, (888) 825-5249 vaccine (oral) NC kidney, leukemia, OGX-427 Oncogenex (see also bladder, Phase I lung, lymphoma, Pharmaceuticals breast, lung, ovarian) (425) 686-1500 multiple myeloma, Bothell, WA ovarian, pancreatic, Oncolar® Novartis Pharmaceuticals Phase II stomach, other) octreotide East Hanover, NJ (888) 669-6682 HyperAcute® NewLink Genetics Phase I/II ONY-105 Onyvax Phase II Prostate prostate Ames, IA (515) 296-5555 (cancer vaccine) London, England www.ony cancer vaccine vax.com idronoxil Marshall Edwards (see also ovarian, other) Phase II ONY-P Onyvax Phase II North Ryde, Australia (prostate cancer London, England www.ony IMC-1121B Eli Lilly (see also breast, colorectal, Phase II vaccine) vax.com Indianapolis, IN kidney, liver, lung, (800) 545-5979 ozarelix Spectrum Phase I/II ImClone Systems ovarian, skin) (212) 645-1405 Pharmaceuticals (949) 788-6700 New York, NY Irvine, CA IMC-A12 Eli Lilly (see also breast, Phase II panobinostat Novartis (see also brain, breast, Phase II Indianapolis, IN colorectal, head/neck, (800) 545-5979 Pharmaceuticals leukemia, (888) 669-6682 ImClone Systems liver, lung, pancreatic, (212) 645-1045 East Hanover, NJ lymphoma) New York, NY sarcoma, solid tumors) plitidepsin PharmaMar USA (see also lung, Phase II INCB-18424 Incyte (see also multiple Phase II Cambridge, MA multiple myeloma) (617) 868-3797 Wilmington, DE myeloma) (302) 498-6700 polyphenon E Polyphenon Pharma prostatic intraepithelial Phase II INSM-18 Insmed Glen Allen, Phase I/II New York, NY neoplasia (see also (212) 661-0578 VA completed bladder, leukemia) (804) 565-3000

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26 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Proscar® Merck prostate cancer Phase III tesmilifene YM BioSciences (see also breast) Phase II finasteride Whitehouse Station, NJ prevention (800) 672-6372 Wayne, PA (610) 560-0600 ProstAtak™ Advantagene Phase II TheraCIM™ YM Biosciences hormone-refractory Phase II gene therapy Boston, MA (617) 916-5445 nimotuzumab Wayne, PA prostate cancer (610) 560-0600 San Diego, CA (760) 943-8981 (see also brain, breast, prostate cancer Novartis Phase I/II stomach) vaccine Pharmaceuticals (888) 669-6682 Thymitaq® YM BioSciences (see also colorectal, Phase II East Hanover, NJ nolatrexed Wayne, PA head/neck, liver, (610) 560-0600 ® lung, pancreatic) oncology-times.com Prostvac -VF BN Immuno Phase II prostate Therapeutics (650) 681-4660 tigapotide Ambrilia Biopharma Phase II cancer vaccine Mountain View, CA Verdun, Canada (514) 751-2003 Provenge® Dendreon hormone-refractory, application Torisel™ Wyeth Pharmaceuticals (see also colorectal, Phase II sipuleucel-T Seattle, WA metastatic prostate submitted temsirolimus Collegeville, PA kidney, lung, (800) 934-5556 cancer (206) 256-4545 lymphoma, multiple non-metastatic Phase III myeloma) androgen-dependent (206) 256-4545 TPI-287 Tapestry hormone-refractory Phase II prostate cancer Pharmaceuticals prostate cancer (303) 516-8500 PRX-302 Protox Therapeutics Phase II Boulder, CO (see also pancreatic) Vancouver, Canada (604) 688-0199 transgenic B Cosmo Bioscience Phase II PSMA-ADC Progenics Pharmaceuticals Phase I lymphocyte San Diego, CA (858) 823-0413 Tarrytown, NY (914) 789-2800 / cancer vaccine PSMA cancer Progenics Pharmaceuticals Phase I vaccine Tarrytown, NY (914) 789-2800 tremelimumab Pfizer high-risk prostate Phase II completed New York, NY cancer (see also (860) 732-5156 Quadramet® Cytogen (see also multiple Phase II breast, colorectal, samarium Princeton, NJ myeloma, (800) 833-3533 kidney, lung, skin) SM-153 sarcoma, other) lexidronam combination therapy Phase I injection (860) 732-5156 ® Quinamed® ChemGenex (see also breast, Phase II Triapine Vion Pharmaceuticals (see also leukemia, Phase II amonafide Pharmaceuticals ovarian) (650) 474-9800 New Haven, CT lung, pancreatic) (203) 498-4210 Menlo Park, CA trilostane Genzyme (see also breast) Phase II Revlimid® Celgene (see also leukemia, Phase II Cambridge, MA (617) 252-7500 lenalidomide Summit, NJ lymphoma, multiple (908) 673-4900 tucotuzumab EMD Serono (see also colorectal, Phase II myeloma, other) celmoleukin Rockland, MA lung, ovarian) (800) 283-8088 romidepsin Gloucester (see also kidney, Phase II VDC2008 Bostwick Laboratories Phase I/II Pharmaceuticals lymphoma, multiple completed Glen Allen, VA (804) 967-9225 Cambridge, MA myeloma, pancreatic) (617) 583-1300 Vidaza® Celgene (see also leukemia, Phase II sagopilone Bayer HealthCare combination therapy Phase II azacitidine Summit,NJ lymphoma) (908) 673-9000 Pharmaceuticals (see also brain, breast, (888) 842-2937 VP101 Access Pharmaceuticals (see also brain, Phase II Wayne, NJ ovarian) Dallas, TX colorectal, leukemia) (214) 905-5100 satraplatin Spectrum hormone-refractory Phase III YM-155 Astellas Pharma US hormone-refractory Phase II Pharmaceuticals prostate cancer (949) 788-6700 Deerfield, IL prostate cancer (800) 727-7003 Irvine, CA (combination therapy, (see also lymphoma) second-line therapy) YMB2002 YM BioSciences Phase II (see also breast, lung) (prostate cancer Wayne, PA (610) 560-0600 seocalcitol Cougar Biotechnology Phase I vaccine) (CB1089) Los Angeles, CA (310) 943-8040 Yondelis® Johnson & Johnson (see also breast, ovarian, Phase II Sprycel™ Bristol-Myers Squibb (see also leukemia, in clinical trials trabectedin Pharmaceutical sarcoma, other) (800) 817-5286 dasatinib Princeton, NJ solid tumors) (212) 546-4000 Research & Sutent® Pfizer hormone-refractory Phase III Development sunitinib New York, NY metastatic prostate (860) 732-5156 Raritan, NJ cancer (see also breast, ZYC300 Eisai (see also breast, Phase I colorectal, liver, lung, Woodcliff Lake, NJ colorectal, kidney, (888) 422-4743 pancreatic, sarcoma, ovarian) stomach) adjunctive treatment Phase II Sarcoma (860) 732-5156 Actimid™ Celgene (see also lung, multiple Phase II TAK683 Millennium Phase I pomalidomide Summit, NJ myeloma, pancreatic, (908) 673-9000 Pharmaceuticals (800) 390-5663 prostate) Cambridge, MA AMG 479 Amgen (see also breast, Phase II TAK700 Millennium Phase I/II Thousand Oaks, CA colorectal, lung, (805) 447-1000 Pharmaceuticals (800) 390-5663 pancreatic) Cambridge, MA Armala™ GlaxoSmithKline (see also brain, breast, Phase III tandutinib Millennium (see also brain) Phase II pazopanib Rsch. Triangle Park, NC cervical, kidney, liver, (888) 669-6682 (MLN0518) Pharmaceuticals (800) 390-5663 lung, ovarian, other) Cambridge, MA LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 27

27 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

AVE8062 sanofi-aventis Phase III soft tissue sarcoma Phase I/II Bridgewater, NJ (800) 633-1610 (626) 441-6695 brostallicin Cell Therapeutics soft tissue sarcoma Phase II robatumumab Schering-Plough , Phase II Seattle, WA (see also solid tumors) (800) 215-2355 Kenilworth, NJ sarcoma (see also (908) 298-4000 cancer vaccine MabVax Therapeutics (see also breast) Phase I colorectal) San Diego, CA (858) 259-9405 Sutent® Pfizer soft tissue sarcoma Phase II conatumumab Amgen (see also colorectal, Phase I/II sunitinib New York, NY (see also breast, (860) 732-5156 Thousand Oaks, CA lung, pancreatic) (805) 447-1000 colorectal, liver, lung, pancreatic, prostate, CP-751871 Pfizer (see also breast, Phase I/II oncology-times.com stomach) New York, NY colorectal, lung, (860) 732-5156 multiple myeloma, tasisulam (ASAP) Eli Lilly soft tissue sarcoma Phase II prostate) Indianapolis, IN (see also leukemia, (800) 545-5979 ovarian, skin) deforolimus ARIAD oral formulation Phase III (MK-8669) Pharmaceuticals (see also breast, lung, (617) 494-0400 TH-302 Threshold soft tissue sarcoma Phase I/II (Orphan Drug) Cambridge, MA prostate, other) (800) 672-6372 Pharmaceuticals (see also solid tumors) (650) 474-8200 Merck Redwood City, CA Whitehouse Station, Yondelis® Johnson & Johnson first-line therapy Phase III NJ intravenous Phase I/II trabectedin Pharmaceutical (see also breast, ovarian, (800) 817-5286 formulation (617) 494-0400 (Orphan Drug) Research & prostate, other) (800) 672-6372 Development eribulin Eisai (see also breast, head/ Phase II Raritan, NJ mesylate Woodcliff neck, lung, ovarian, (877) 873-4724 in adolescents and Phase II (E7389) Lake, NJ prostate, solid tumors) children (800) 817-5286 Fusilev™ Spectrum (see also colorectal) application Skin Cancer levoleucovorin Pharmaceuticals submitted for injection Irvine, CA (949) 788-6700 1203486A GlaxoSmithKline malignant Phase II Gemzar® Eli Lilly (see also head/neck, Phase II Rsch. Triangle Park, (888) 825-5249 gemcitabine Indianapolis, IN lung, lymphoma) (800) 545-5979 NC glufosfamide Threshold (see also breast, lung, Phase II 2132231A GlaxoSmithKline malignant melanoma Phase III Pharmaceuticals pancreatic) (650) 474-8200 Rsch. Triangle Park, (888) 825-5249 Redwood City, CA NC IMC-A12 Eli Lilly soft tissue sarcoma Phase II Abraxane™ Abraxis BioScience malignant melanoma Phase II Indianapolis, IN (see also breast, (800) 545-5979 albumin-bound Los Angeles, CA (see also head/neck, (310) 883-1300 ImClone Systems colorectal, head/ (212) 645-1405 paclitaxel lung, ovarian, New York, NY neck, liver, lung, pancreatic, prostate) pancreatic, ABT-888 Abbott Laboratories malignant melanoma Phase II prostate, solid Abbott Park, IL (see also solid tumors) (847) 937-6100 tumors) Allovectin-7® Vical metastatic melanoma Phase III Junovan™ IDM Pharma osteosarcoma application velimogene San Diego, CA (858) 646-1100 mifamurtide Irvine, CA submitted aliplasmid (949) 470-4751 (immunotherapeutic KRX-0402 Keryx (see also brain, Phase II vaccine) Biopharmaceuticals colorectal, kidney, (212) 531-5965 (Orphan Drug) New York, NY multiple myeloma) ALS-357 Advanced Life Sciences malignant melanoma Phase I palifosfamide ZIOPHARM combination therapy Phase II (betulinic topical) Woodridge, IL (630) 739-6744 (ZIO-201) Oncology (see also solid tumors) (212) 214-0700 Amplimexon® AmpliMed malignant melanoma Phase I/II (Orphan Drug) New York, NY imexon Tucson, AZ (see also breast, lung, completed monotherapy Phase I/II multiple myeloma, (520) 529-1000 (212) 214-0700 pancreatic, prostate) perifosine AEterna Zentaris (see also brain, head/ Phase II ATN-224 Attenuon malignant melanoma Phase II Montreal, Canada neck, kidney, (212) 531-5965 San Diego, CA (see also multiple (858) 720-8797 Keryx lymphoma, multiple myeloma, prostate) Biopharmaceuticals myeloma, ovarian) AZD6244 AstraZeneca malignant melanoma Phase II New York, NY Wilmington, DE (see also leukemia, liver, (800) 236-9933 Quadramet® Cytogen osteosarcoma Phase I/II lung, multiple myeloma, samarium Princeton, NJ (see also multiple (800) 833-3533 ovarian, pancreatic, sm-153 myeloma, other) lexidronam prostate, other) Azixa™ Myriad malignant melanoma Phase I/II injection (MPC-6827) Pharmaceuticals (see also brain) (801) 584-3600 R1507 Roche (see also breast, lung, Phase II Salt Lake City, UT Nutley, NJ lymphoma) (973) 235-5000 BMS-663513 Bristol-Myers Squibb second-line melanoma in clinical trials Reolysin® Oncolytics Biotech (see also brain, head/ Phase II (anti-CD137 Princeton, NJ (212) 546-4000 reovirus Calgary, Canada neck, lung, skin) (403) 670-7377 antibody) Rexin-G™ Epeius Biotechnologies osteosarcoma Phase II Cadi 05 Cadila Pharmaceuticals malignant melanoma Phase I/II tumor-targeted San Marino, CA (see also breast, (626) 441-6695 Bhat, India (see also solid tumors) www.cadi gene therapy pancreatic) lapharma.com

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28 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

CNTO 95 Centocor malignant melonoma Phase I/II Marqibo™ Hana Biosciences malignant melanoma Phase II Horsham, PA (see also prostate, (610) 651-6000 vincristine South San Francisco, (see also leukemia) (650) 588-6404 solid tumors) liposomal CA CR011-vcMMAE CuraGen malignant melanoma Phase II (Orphan Drug) Branford, CT (see also breast) (888) 436-6642 MDX-010 Bristol-Myers Squibb adjuvant melanoma, Phase III CYT-107 Cytheris malignant melanoma Phase I/II () Princeton, NJ metastatic melanoma (212) 546-4000 Rockville, MD (see also kidney, (301) 231-0450 Medarex Princeton, NJ (see also solid tumors) leukemia, solid melanoma Ichor Medical Systems malignant melanoma Phase I tumors) vaccine San Diego, CA (858) 550-2022 oncology-times.com denenicokin ZymoGenetics malignant melanoma Phase I/II melanoma Novavax malignant melanoma Phase I (IL-21) Seattle, WA (see also colorectal, (206) 442-6600 vaccine Malvern, PA (484) 913-1200 kidney, lymphoma, melanoma sanofi-aventis treatment of stage III Phase II ovarian) vaccine Bridgewater, NJ and stage IV melanoma (800) 633-1610 ® Dimericine AGI Dermatics Phase II Melaxin® Oncolix malignant melanoma Phase II T4N5 liposome Freeport, NY (516) 868-9026 autologous Greenville, SC lotion dendritoma dovitinib Novartis malignant melanoma Phase I/II vaccine Pharmaceuticals (see also kidney) (888) 669-6682 Metvixia® PhotoCure basal cell cancer Phase III East Hanover, NJ methyl Oslo, Norway www.photo Life Sciences malignant melanoma Phase II aminolevulinate cure.com Pharmaceuticals (combination therapy) (203) 422-6500 MKC 1106-MT MannKind malignant melanoma Phase I Greenwich, CT Valencia, CA (661) 775-5300 Elacyt™ Clavis Pharma malignant melanoma Phase II M-Vax® AVAX Technologies malignant melanoma Phase III elacytarabine Oslo, Norway (combination therapy), www.clavis melanoma Philadelphia, PA (215) 241-9760 malignant melanoma pharma.com vaccine (first-line therapy) Nexavar® Bayer HealthCare malignant melanoma Phase III (see also leukemia, sorafenib Pharmaceuticals (combination therapy) (888) 842-2837 ovarian) Wayne, NJ (see also breast, lung) (510) 597-6500 EMD 273063 EMD Serono malignant melanoma Phase II Onyx Pharmaceuticals Rockland, MA (see also brain) (800) 283-8088 Emeryville, CA Exherin™ Adherex Technologies malignant melanoma Phase I/II ODC-0501 ODC Therapy malignant melanoma Phase I/II (ADH-1) Durham, NC (see also solid tumors) (919) 484-8484 Dallas, TX (214) 826-7019 GC-1008 Genzyme malignant melanoma Phase I Oncophage® Antigenics malignant melanoma Phase III Cambridge, MA (see also kidney) (617) 252-7000 vitespen New York, NY (see also brain, (866) 805-8994 Genasense® Genta malignant melanoma Phase III colorectal, kidney, oblimersen Berkeley Heights, NJ (see also breast, (908) 286-9800 pancreatic, stomach) (Orphan Drug) leukemia, lung, OncoVAX® Vaccinogen malignant melanoma Phase I/II lymphoma, solid cancer vaccine Frederick, MD (see also colorectal, (301) 668-8400 tumors) kidney) GMX-1777 Gemin X malignant melanoma Phase I/II OncoVEX BioVex malignant melanoma Phase II Biotechnologies (combination therapy)(514) 281-8989 GM-CSF Woburn, MA (see also pancreatic) (781) 376-4900 Montreal, Canada (see also lymphoma, PARP inhibitor Genentech malignant melanoma Phase I solid tumors) South San Francisco, (650) 225-1000 ® HyperAcute NewLink Genetics malignant melanoma Phase I/II CA Melanoma Ames, IA (515) 296-5555 PEG-Intron A® Schering-Plough adjunctive treatment application melanoma peginterferon Kenilworth, NJ of stage III malignant submitted vaccine alfa-2b melanoma (see also IMC-1121B Eli Lilly metastatic malignant Phase II leukemia) (908) 298-4000 Indianapolis, IN melanoma (see also (800) 545-5979 PEP-005 Peplin basal cell cancer Phase II ImClone Systems breast, colorectal, (212) 645-1405 Emeryville, CA (510) 653-9700 New York, NY kidney, liver, lung, ovarian, prostate) PHP Curacyte malignant melanoma Phase II Chapel Hill, NC www.cura INGN 241 Introgen Therapeutics malignant melanoma Phase II cyte.com (mda-7) Austin, TX (see also head/neck) (512) 708-9310 PI-88 Progen malignant melanoma Phase II interleukin-12 Inovio malignant melanoma Phase I Pharmaceuticals (650) 610-7080 gene therapy San Diego, CA (877) 446-6846 Redwood City, CA Karenitecin® BioNumerik malignant melanoma Phase II PLX-4032 Plexxikon malignant melanoma Phase I cositecan Pharmaceuticals (see also brain, lung, completed Berkeley, CA (510) 647-4000 San Antonio, TX ovarian) (201) 614-1710 Roche (973) 235-5000 ® Leukine Bayer HealthCare malignant melanoma Phase II Nutley, NJ sargramostim Pharmaceuticals (see also leukemia, (888) 842-2937 PTC-299 PTC Therapeutics Kaposi’s sarcoma Phase I/II Wayne, NJ lymphoma, ovarian, South Plainfield, CT (see also breast) (908) 222-7000 prostate) PV-10 Provectus malignant melanoma Phase II Lymphoseek™ Neoprobe diagnosis of malignant Phase III Pharmaceuticals (866) 594-5999 Dublin, OH melanoma (see also (800) 793-0079 Knoxville, TN breast) 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29 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

RAF265 Novartis malignant melanoma Phase I AEW541 Novartis (see also leukemia) Phase I Pharmaceuticals (888) 669-6682 Pharmaceuticals (888) 669-6682 East Hanover, NJ East Hanover, NJ Reolysin® Oncolytics Biotech malignant melanoma Phase II AFP-464 Tigris Pharmaceuticals Phase I reovirus Calgary, Canada (see also brain, head/ (403) 670-7377 Bonita Springs, FL (239) 444-5400 neck, lung, sarcoma) AI-850 Acusphere Phase I systemic Genentech basal cell cancer Phase II Watertown, MA (617) 648-8800 hedgehog South San Francisco, (see also brain, (650) 224-1000 Cephalon (610) 344-0200 antagonist CA colorectal, ovarian) Frazer, PA oncology-times.com tasisulam Eli Lilly malignant melanoma Phase II ALB 109564(a) AMRI Phase I (ASAP) Indianapolis, IN (see also leukemia, (800) 545-5979 Albany, NY (518) 512-2000 ovarian, sarcoma) AMG 208 Amgen Phase I TM-601-I-131 TransMolecular metastatic malignant Phase I/II Thousand Oaks, CA (805) 447-1000 Cambridge, MA melanoma (see also (617) 995-3050 AMG 888 Amgen Phase I brain) (U3-1287) Thousand Oaks, CA (805) 447-1000 TNFerade™ GenVec malignant melanoma Phase II Daiichi Sankyo (973) 359-2600 Gaithersburg, MD (see also colorectal, (240) 632-0740 Parsippany, NJ head/neck, pancreatic, ANA-773 Anadys Phase I stomach) Pharmaceuticals (858) 530-3600 tremelimumab Pfizer malignant melanoma Phase II San Diego, CA New York, NY (see also breast, (860) 732-5156 angiostatic Angiogen Phase I colorectal, kidney, cocktail Evanston, IL (847) 866-6700 lung, prostate) anti-EGFR Abbott Laboratories Phase I VCL-IM01 Vical metastatic malignant Phase I mAb-806 Abbott Park, IL (847) 937-6100 San Diego, CA melanoma (858) 646-1100 anti-IGF-1R Genentech Phase I veglin VasGene Therapeutics Kaposi’s sarcoma Phase I mAb South San Francisco, CA (650) 225-1000 Los Angeles, CA (323) 221-7818 AR-67 Arno Therapeutics Phase I ® Visudyne QLT USA malignant melanoma Phase I/II Fairfield, NJ (862) 703-7170 Fort Collins, CO (800) 663-5486 ARQ-197 ArQule microphthalmia Phase I/II volociximab Biogen Idec malignant melanoma Phase II Woburn, MA (781) 994-0300 Cambridge, MA (see also lung, (617) 679-2000 Daiichi Sankyo factor tumors (973) 359-2600 Facet Biotech ovarian, pancreatic) (650) 454-1000 Parsippany, NJ (see also liver, lung, Redwood City, CA pancreatic) Zadaxin® SciClone malignant melanoma Phase II ARQ-501 ArQule refractory metastatic Phase I/II thymalfasin Pharmaceuticals (650) 358-3456 (beta lapachone) Woburn, MA solid tumors (781) 994-0300 Foster City, CA (combination therapy) ZRx101 ZelleRx malignant melanoma Phase I (see also head/neck, Chicago, IL (see also kidney, (312) 243-5200 pancreatic, other) multiple myeloma, ARRY-520 Array BioPharma (see also leukemia) Phase I cancer-related) Boulder, CO (303) 381-6600 AT7519 Astex Therapeutics Phase I Solid Tumors Cambridge, 461364 GlaxoSmithKline (see also lymphoma) Phase I United Kingdom Rsch. Triangle Park, (888) 825-5249 AT9283 Astex Therapeutics (see also leukemia) Phase I NC Cambridge, 690693 GlaxoSmithKline (see also lymphoma) Phase I United Kingdom Rsch. Triangle Park, (888) 825-5249 AT13387 Astex Therapeutics Phase I NC Cambridge, 923295 GlaxoSmithKline refractory metastatic Phase I United Kingdom Rsch. Triangle Park, disease (888) 825-5249 ATN-161 Attenuon San Diego, Phase I NC CA (858) 720-8797 1MT NewLink Genetics Phase I AUY922 Novartis (see also multiple Phase I/II Ames, IA (515) 296-5555 Pharmaceuticals myeloma) (888) 669-6682 2DG Threshold Phase I East Hanover, NJ (2-deoxy- Pharmaceuticals (605) 474-8200 AV-299 AVEO advanced solid tumors Phase I d-) Redwood City, CA (SCH-90015) Pharmaceuticals (see also lymphoma) (617) 299-5000 ABI-009 Abraxis BioScience Phase I Cambridge, MA Los Angeles, CA (310) 883-1300 Schering-Plough Kenilworth, NJ ABT-828 Abbott Laboratories Phase I Abbott Park, IL (847) 937-6100 AV-412 AVEO Phase I Pharmaceuticals (617) 299-5000 ABT-888 Abbott Laboratories (see also skin) Phase I Cambridge, MA Abbott Park, IL (847) 937-6100 axitinib Pfizer New York, NY combination therapy, Phase I AEE788 Novartis (see also brain) Phase I late-stage disease (860) 732-5156 Pharmaceuticals (888) 669-6682 (see also colorectal, East Hanover, NJ kidney, lung, other)

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30 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

AZD4769 AstraZeneca Phase I carfilzomib Proteolix relapsed solid tumors Phase I/II Wilmington, DE (800) 236-9933 South San Francisco, (see also leukemia, (650) 615-7550 AZD6918 AstraZeneca Phase I CA multiple myeloma) Wilmington, DE (800) 236-9933 CBP501 Millennium (see also lung) Phase I AZD7762 AstraZeneca Phase I Pharmaceuticals (800) 390-5663 Wilmington, DE (800) 236-9933 Cambridge, MA AZD8055 AstraZeneca Phase I/II CDX-110 Celldex Therapeutics (see also brain) Phase I Wilmington, DE (800) 236-9933 Needham, MA (781) 433-0771 Pfizer (860) 732-5156 oncology-times.com AZD8330 AstraZeneca Phase I New York, NY Wilmington, DE (800) 236-9933 CEP-11981 Cephalon Phase I AZD8931 AstraZeneca Phase I Frazer, PA (610) 344-0200 Wilmington, DE (800) 236-9933 cevipabulin Wyeth Pharmaceuticals Phase I AZM475271 AstraZeneca (see also leukemia) Phase I Collegeville, PA (800) 934-5556 Wilmington, DE (800) 236-9933 CG-201 CG Therapeutics Phase I BEZ235 Novartis Phase I Seattle, WA (206) 336-5604 Pharmaceuticals (888) 669-6682 East Hanover, NJ cilengitide EMD Serono late-stage solid tumors Phase I Rockland, MA (see also brain, (800) 283-8088 BGT226 Novartis Phase I/II lymphoma, prostate) Pharmaceuticals (888) 669-6682 East Hanover, NJ CNF-2024 Biogen Idec (see also breast, Phase I Cambridge, MA leukemia, stomach) (617) 679-2000 BHQ880 Novartis Phase I Pharmaceuticals (888) 669-6682 CNTO 95 Centocor (see also prostate, skin) Phase I East Hanover, NJ Horsham, PA completed (610) 651-6000 BI 6727 Boehringer Ingelheim Phase I Pharmaceuticals (800) 243-0127 CNTO 888 Centocor Phase I Ridgefield, CT Horsham, PA (610) 651-6000 BI 831266 Boehringer Ingelheim Phase I CP-870893 Pfizer Phase I Pharmaceuticals (800) 243-0127 New York, NY (860) 732-5156 Ridgefield, CT crinobulin EpiCept (see also lymphoma) Phase I BIBF 1120 Boehringer Ingelheim combination therapy Phase I Tarrytown, NY (914) 606-3500 Pharmaceuticals (see also lung) (800) 243-0127 CRx-026 CombinatoRx late-stage, metastatic Phase I/II Ridgefield, CT Cambridge, MA solid tumors (617) 301-7000 BIIB 015 Biogen Idec Phase I CUDC-101 Curis Phase I Cambridge, MA (617) 679-2000 Cambridge, MA (617) 503-6500 BIIB 022 Biogen Idec Phase I CX-4945 Cylene (see also multiple Phase I Cambridge, MA (617) 679-2000 Pharmaceuticals myeloma, other) (858) 875-5100 BMS-690514 Bristol-Myers Squibb (see also lung) in clinical trials San Diego, CA (ErbB/VEGF Princeton, NJ (212) 546-4000 CYC-116 Cyclacel Phase I receptor Pharmaceuticals (908) 517-7330 inhibitor) Berkeley Heights, NJ BMS-754807 Bristol-Myers Squibb in clinical trials CYT-107 Cytheris (see also kidney, Phase I (IGF-1R Princeton, NJ (212) 546-4000 Rockville, MD leukemia, skin) (301) 231-0450 antagonist) CYT 6091 CytImmune Sciences Phase I BMS-833923 Bristol-Myers Phase I Rockville, MD (240) 864-2796 (SMO inhibitor) Squibb (212) 546-4000 darinaparsin ZIOPHARM (see also leukemia, Phase I Princeton, NJ (ZIO-101) Oncology liver, multiple (646) 214-0700 Exelixis New York, NY myeloma) South San Francisco Davanat™ Pro-Pharmaceuticals (see also colorectal) Phase I BMS-844203 Bristol-Myers Squibb (see also brain) in clinical trials galactomannan C Newton, MA (617) 559-0033 (VEGF inhibitor- Princeton, NJ (212) 546-4000 adnectin) denibulin MediciNova Phase I (MN-029) San Diego, CA (858) 373-1500 bosutinib Wyeth Pharmaceuticals (see also breast, leukemia) Phase I Collegeville, PA (800) 934-5556 DMPEN Antisoma Phase I Cambridge, MA (617) 225-0522 BQS481 Novartis Phase I Pharmaceuticals (888) 669-6682 E6201 Eisai advanced solid tumors Phase I East Hanover, NJ Woodcliff Lake, NJ (888) 422-4743 brostallicin Cell Therapeutics advanced solid tumors Phase II E7050 Eisai Phase I Seattle, WA (see also sarcoma) (800) 215-2355 Woodcliff Lake, NJ (888) 422-4743 combination therapy Phase I/II E7080 Eisai (see also other) Phase I/II (800) 215-2355 Woodcliff Lake, NJ (888) 422-4743 Cadi 05 Cadila Pharmaceuticals (see also skin) Phase I ENMD-2076 EntreMed refractory metastatic Phase I Bhat, India www.cadila Rockville, MD disease (see also (240) 864-2600 pharma.com multiple myeloma) CALAA 01 Calando Pharmaceuticals Phase I eniluracil Adherex Technologies (see also liver) Phase I Pasadena, CA (626) 683-7200 Durham, NC (919) 484-8484 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 31

31 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

eribulin mesylate Eisai advanced solid tumors, Phase I LE-DT NeoPharm Lake Phase I (E7389) Woodcliff Lake, NJ solid tumors (see also (888) 422-4743 Bluff, IL (847) 887-0800 breast, head/neck, lung, Human Genome Phase I ovarian, prostate, sarcoma) Sciences Rockville, MD (301) 309-8504 Exherin™ Adherex Technologies (see also skin) Phase II L-MDAM BioNumerik Phase I (ADH-1) Durham, NC (919) 484-8484 Pharmaceuticals (210) 614-1701 EZN-2968 Enzon Pharmaceuticals (see also lymphoma) Phase I San Antonio, TX Bridgewater, NJ (866) 792-5172 LP-261 Locus Pharmaceuticals Phase I

FP-1039 Five Prime Therapeutics Phase I Blue Bell, PA (215) 358-2000 oncology-times.com San Francisco, CA (415) 365-5600 LY2157299 Eli Lilly Phase I Genasense® Genta brief, high-dose Phase I/II Indianapolis, IN (800) 545-5979 oblimersen Berkeley Heights, NJ IV-infusion (see also (908) 286-9800 LY2181308 Eli Lilly (see also leukemia) Phase II breast, leukemia, lung, Indianapolis, IN (800) 545-5979 lymphoma, skin) Isis Pharmaceuticals (760) 931-9200 intermittent therapy Phase I Carlsbad, CA (908) 286-9800 LY2275796 Eli Lilly Phase I GMX-1777 Gemin X (see also lymphoma, Phase I Indianapolis, IN (800) 545-5979 Biotechnologies skin) (514) 281-8989 Isis Pharmaceuticals (760) 931-9200 Montreal, Canada Carlsbad, CA HGS-1029 Human Genome Phase I LY2334737 Eli Lilly Phase I Sciences Rockville, MD (301) 309-8504 Indianapolis, IN (800) 545-5979 HMN-214 NS Pharma Phase I LY2603618 Eli Lilly Phase I Parsippany, NJ (973) 285-7010 Indianapolis, IN (800) 545-5979 IMC-3G3 Eli Lilly Phase I M1685A Genentech Phase I Indianapolis, IN (800) 545-5979 South San Francisco, (650) 224-1000 ImClone Systems (212) 645-1405 CA New York, NY MDX-010 Bristol-Myers Squibb (see also skin) in clinical trials IMC-18F1 Eli Lilly Phase I (ipilimumab) Princeton, NJ (212) 546-4000 Indianapolis, IN (800) 545-5979 Medarex ImClone Systems (212) 645-1405 Princeton, NJ New York, NY MDX-1105 Medarex Phase I IMC-A12 Eli Lilly solid tumors in Phase I/II Princeton, NJ (609) 430-2880 Indianapolis, IN adolescents and (800) 545-5979 MDX-1106 Medarex Phase I ImClone Systems children (212) 645-1405 Princeton, NJ (609) 430-2880 New York, NY (see also breast, MDX-1307 Medarex Phase I colorectal, head/neck, Princeton, NJ (609) 430-2880 liver, lung, pancreatic, prostate, sarcoma) MEDI-575 MedImmune Phase I Gaithersburg, MD (301) 398-0000 solid tumor combination Phase I therapy, other (800) 545-5979 MetmAb Genentech Phase I solid tumors (212) 645-1405 South San Francisco, CA (650) 225-1000 IMGN-242 ImmunoGen (see also stomach) Phase I MGCD-265 MethylGene Phase I Cambridge, MA (617) 995-2500 Montreal, Canada (514) 337-3333 IMGN-388 ImmunoGen Phase I MGCD-0103 MethylGene combination therapy Phase I/II Cambridge, MA (617) 679-5500 Montreal, Canada (see also leukemia, 514) 337-3333 lymphoma) INNO-206 CytRx Phase I Los Angeles, CA (310) 826-5648 monotherapy Phase I (514) 337-3333 INNO-305 CytRx (see also leukemia) Phase I Los Angeles, CA (310) 826-5648 MK-0731 Merck Phase I Whitehouse Station, completed IPI-493 Infinity Phase I NJ (800) 672-6372 Pharmaceuticals (617) 453-1000 Cambridge, MA MK-1775 Merck Phase I Whitehouse Station, (800) 672-6372 IPI-926 Infinity Phase I NJ Pharmaceuticals (617) 453-100 Cambridge, MA MK-2206 Merck Phase I Whitehouse Station, (800) 672-6372 JI-101 Jubilant Innovation Phase I NJ Bedminster, NJ (215) 369-0965 MK-5108 Merck refractory metastatic Phase I JNJ-38877605 Johnson & Johnson Phase I Whitehouse Station, NJ disease (800) 672-6372 Pharmaceutical (800) 817-5286 Research & Cambridge, MA Development Raritan, NJ MKC1106-PP MannKind Phase I Valencia, CA (661) 775-5300 JX-594 Jennerex (see also liver) Phase I Biotherapeutics (415) 281-8886 MLN4924 Millennium (see also leukemia) Phase I San Francisco, CA Pharmaceuticals (800) 390-5663 Cambridge, MA

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32 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

MLN8237 Millennium (see also brain, Phase I PM-02734 PharmaMar USA Phase I Pharmaceuticals leukemia, lymphoma)(800) 390-5663 Cambridge, MA (617) 868-3797 Cambridge, MA PRLX-93936 Prolexys Phase I MM-121 Merrimack Phase I Pharmaceuticals (801) 303-1700 Pharmaceuticals (617) 441-1000 Salt Lake City, UT Cambridge, MA PRX-321 Protox Therapeutics (see also brain) Phase I MN-201 Marillion advanced solid tumors Phase I Vancouver, Canada completed Pharmaceuticals (610) 644-5732 (604) 688-0199 Malvern, PA oncology-times.com PX-478 Oncothyreon (see also lymphoma) Phase I MORAb-004 Eisai Phase I Seattle, WA (206) 801-2100 Woodcliff Lake, NJ (888) 422-4743 PX-866 Oncothyreon Phase I MP-470 SuperGen Phase I Seattle, WA (206) 801-2100 Dublin, CA (925) 560-0100 R547 Roche Phase I MSX-122 Metastatix Tucker, late-stage solid tumors Phase I Nutley, NJ (973) 235-5000 GA (678) 367-0720 R763 EMD Serono Phase I NB-1011 Kiadis Pharma Phase I/II Rockland, MA (800) 283-8088 Amsterdam, Rigel Pharmaceuticals (650) 624-1100 The Netherlands South San Francisco, NKTR-105 Nektar Therapeutics Phase I CA San Carlos, CA (650) 631-3100 R1530 Roche Nutley, NJ Phase I NPI-0052 Nereus Pharmaceuticals (see also lymphoma, Phase I (973) 235-5000 San Diego, CA multiple myeloma) (858) 587-4090 R4733 Roche Nutley, NJ Phase I oleandrin Ozelle Pharmaceuticals Phase I (973) 235-5000 (nerium San Antonio, TX (309) 949-3745 R7112 Roche Nutley, NJ (see also leukemia) Phase I oleander extract) (973) 235-5000 OMP-21M18 GlaxoSmithKline Phase I R7167 Roche Nutley, NJ Phase I Rsch. Triangle Park, NC (888) 825-5249 (973) 235-5000 OncoMed (650) 995-8200 R7304 Roche Nutley, NJ Phase I Pharmaceuticals (973) 235-5000 Redwood City, CA R7347 Roche Nutley, NJ Phase I omtriptolide Pharmagenesis Phase I (973) 235-5000 Palo Alto, CA (650) 813-1818 RH-1 Allos Therapeutics (see also lymphoma) Phase I Pierre Fabre (973) 898-1042 Westminster, CO (303) 426-6262 Pharmaceuticals Parsippany, NJ rinfabate Insmed Phase I (rhIGFBP-3) Glen Allen, VA completed ON-01910 Onconova (see also leukemia) Phase I (804) 565-3000 Therapeutics (609) 844-7735 Princeton, NJ RO-4987655 Roche Phase I Nutley, NJ (973) 235-5000 Oncaspar® Enzon Pharmaceuticals combination therapy Phase I pegaspargase Bridgewater, NJ (see also lymphoma) (866) 792-5172 RO-5083945 Roche Phase I Nutley, NJ (973) 235-5000 OSI-906 OSI Pharmaceuticals Phase I Melville, NY (631) 962-2000 sardomozide Novartis (see also lymphoma) Phase I Pharmaceuticals (888) 669-6682 OSI-930 OSI Pharmaceuticals Phase I East Hanover, NJ Melville, NY (631) 962-2000 SCH-900776 Schering-Plough (see also lymphoma) Phase I PI3 kinase Genentech Phase I Kenilworth, NJ (908) 298-4000 inhibitor South San Francisco, CA (650) 224-1000 SF1126 Semafore (see also mutliple Phase I palifosfamide ZIOPHARM combination therapy Phase I Pharmaceuticals myeloma) (317) 876-3075 (ZIO-201) Oncology (see also sarcoma) (212) 214-0700 Indianapolis, IN New York, NY simotaxel Taxolog Phase I PCI-24781 Pharmacyclics (see also leukemia) Phase I Fairfield, NJ (877) 829-6564 Sunnyvale, CA (408) 774-0330 Wyeth Pharmaceuticals (800) 934-5556 PDL-192 Facet Biotech Phase I Collegeville, PA Redwood City, CA (650) 454-1000 SN2310 OncoGenex Phase I PF-477736 Pfizer Phase I Pharmaceuticals (425) 686-1500 New York, NY (860) 732-5156 Bothell, WA PF-3814735 Pfizer Phase I SNS-032 Sunesis Pharmaceuticals (see also lymphoma) Phase I/II New York, NY (860) 732-5156 South San Francisco, (650) 266-3500 PF-4856882 Pfizer Phase I CA (CovX045) New York, NY (860) 732-5156 SNS-314 Sunesis Phase I PG-11047 Progen Phase I Pharmaceuticals Pharmaceuticals (650) 610-7800 South San Francisco, (650) 266-3500 Redwood City, CA CA PM-00104 PharmaMar USA (see also lymphoma) Phase I sonepcizumab Lpath Phase I Cambridge, MA (617) 868-3797 San Diego, CA (858) 678-0800 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 33

33 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

SPI-1620 Spectrum adjunctive treatment Phase I XL-888 Exelixis Phase I Pharmaceuticals (949) 788-6700 South San Francisco, CA (650) 837-7000 Irvine, CA XMT-1001 Mersana Therapeutics refractory metastatic Phase I Sprycel™ Bristol-Myers Squibb (see also leukemia, in clinical trials Cambridge, MA disease (617) 498-0020 dasatinib Princeton, NJ prostate) (212) 546-4000 ZEN-012 AEterna Zentaris (see also lymphoma) Phase I SSR97225 sanofi-aventis Phase I Warren, NJ (908) 626-5428 Bridgewater, NJ (800) 633-1610 ZIO-301 ZIOPHARM combination therapy Phase I/II STA-9090 Synta Pharmaceuticals (see also leukemia) Phase I (indibulin) Oncology (646) 214-0700

Lexington, MA (781) 274-8200 New York, NY oncology-times.com TAK593 Millennium Phase I monotherapy Phase I Pharmaceuticals (800) 390-5663 (646) 214-0700 Cambridge, MA tanespimycin Bristol-Myers Squibb (see also multiple Phase II Stomach Cancer (Hsp90 Princeton, NJ myeloma) (212) 546-4000 Advexin® Introgen Therapeutics esophageal cancer Phase I/II inhibitor) contusugene Austin, TX (see also bladder, brain, (512) 708-9310 Tarvacin™ Peregrine Phase I ladenovec breast, head/neck, Pharmaceuticals (714) 508-6000 lung, ovarian, prostate) Tustin, CA AMG 102 Amgen gastric cancer Phase I/II TGF beta Eli Lilly Phase I Thousand Oaks, CA (see also brain, (805) 447-1000 inhibitor Indianapolis, IN (800) 545-5979 colorectal, kidney, TH-302 Threshold combination therapy Phase I/II lung) Pharmaceuticals (see also sarcoma) (650) 474-8200 AMG 386 Amgen gastrointestinal cancer Phase II Redwood City, CA Thousand Oaks, CA (see also breast, kidney, (805) 447-1000 monotherapy Phase I ovarian, other) (650) 474-8200 AV-951 AVEO Pharmaceuticals gastrointestinal cancer Phase I/II TLC388 Taiwan Liposome Phase I Cambridge, MA (combination therapy) (617) 299-5000 Taipei, Taiwan (see also kidney, lung) ® TRC-093 TRACON Phase I Avastin Genentech gastric cancer Phase III Pharmaceuticals (858) 550-0780 bevacizumab South San Francisco, (combination therapy), (650) 225-1000 San Diego, CA CA gastrointestinal stromal tumor (GIST) tricirbine VioQuest (see also leukemia) Phase I/II (see also brain, colorectal, (VQD-002) Pharmaceuticals (908) 766-4400 head/neck, kidney, liver, Basking Ridge, lung, lymphoma, NJ multiple myeloma, TST-10088 Twinstrand Phase I ovarian, pancreatic, Therapeutics North (604) 960-0857 prostate, other) Vancouver, Canada CNF-2024 Biogen Idec GIST Phase II UNBS-5162 Drais Pharmaceuticals (see also lymphoma) Phase I Cambridge, MA (see also breast, (617) 679-2000 Bridgewater, NJ (908) 895-1200 leukemia, solid tumors) V935 Merck Phase III Erbitux® Bristol-Myers Squibb esophageal cancer, Phase III Whitehouse Station, NJ (800) 672-6372 cetuximab Princeton, NJ gastric cancer (212) 546-4000 Velcade® Millennium (see also lung, lymphoma, Phase I/II Eli Lilly (see also bladder, (800) 545-5979 bortezomib Pharmaceuticals multiple myeloma)(800) 390-5663 Indianapolis, IN colorectal, head/neck, (212) 645-1405 Cambridge, MA ImClone Systems lung, prostate) vinorelbine Hana Biosciences (see also lymphoma) Phase I New York, NY liposomal South San Francisco, (650) 588-6404 Herceptin® Genentech esophageal cancer, Phase III CA trastuzumab South San Francisco, gastric cancer (see also (650) 225-1000 VQD-001 VioQuest Phase I/II CA colorectal, ovarian, Pharmaceuticals (908) 766-4400 pancreatic, prostate, Basking Ridge, NJ other) ® WX UK1 Wilex combination therapy Phase I Hycamtin GlaxoSmithKline esophageal cancer, Phase II Munich, Germany www.wilex.com topotecan Rsch. Triangle Park, gastric cancer (see also (888) 825-5249 NC breast, colorectal, head/ XL-147 Exelixis Phase I neck, kidney, leukemia, South San Francisco, (650) 837-7000 lung, lymphoma, CA multiple myeloma, XL-281 Bristol-Myers Squibb Phase I ovarian, pancreatic, (RAF kinase Princeton, NJ (212) 546-4000 prostate, other) inhibitor) Exelixis IMGN-242 ImmunoGen gastric cancer Phase II South San Francisco, CA Cambridge, MA (see also solid tumors) (617) 995-2500 XL-518 Exelixis Phase I Levulan® PD DUSA Pharmaceuticals gastrointestinal cancer in clinical trials (MEK inhibitor) South San Francisco, CA (650) 837-7000 aminolevulinic Wilmington, MA (see also bladder, (978) 657-7500 Genentech acid cervical, colorectal, lung) South San Francisco, CA masitinib AB Science USA GIST Phase III XL-765 Exelixis (see also brain) Phase I Short Hills, NJ (see also leukemia, (973) 218-2437 South San Francisco, CA (650) 837-7000

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34 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

pancreatic) East Hanover, NJ myeloma) OncoGel™ Protherics esophageal cancer Phase II Bexxar® GlaxoSmithKline myeloablation Phase II Brentwood, TN (see also brain, (615) 327-1027 tositumomab Rsch. Triangle Park, (see also leukemia, (888) 825-5249 pancreatic) NC lymphoma) Oncophage® Antigenics (see also brain, Phase I/II CB-1400 Canopus BioPharma mucositis (prevention) Phase II vitespen New York, NY colorectal, kidney, (866) 805-8994 Studio City, CA (818) 980-5008 pancreatic, skin) CJ-15161 Pfizer cancer pain Phase II Opaxio™ Cell Therapeutics esophageal cancer, Phase I New York, NY (860) 732-5156 paclitaxel Seattle, WA gastric cancer (see also (800) 215-2355 oncology-times.com denosumab Amgen bone loss induced Phase III poliglumex Novartis lung, ovarian, other) (888) 669-6682 (AMG 162) Thousand Oaks, CA by hormone- (805) 447-1000 Pharmaceuticals ablation therapy in East Hanover, NJ breast or prostate PN401 Wellstat Therapeutics (see also colorectal, Phase II cancers, prevention of Gaithersburg, MD pancreatic) (240) 631-2500 cancer-related bone PX-12 Oncothyreon gastrointestinal cancer Phase I damage in breast, Seattle, WA (see also pancreatic, (206) 801-2100 prostate, or solid tumors other) (see also multiple myeloma, other) retaspimycin Infinity GIST Phase III ® (IPI 504) Pharmaceuticals (see also breast, lung) (617) 453-1000 Elitek sanofi-aventis -induced application (Orphan Drug) Cambridge, MA rasburicase Bridgewater, NJ hyperuricemia in adults submitted (800) 633-1610 Sutent® Pfizer gastric cancer Phase II ® sunitinib New York, NY (combination therapy) (860) 732-5156 Enbrel Amgen graft-versus-host disease Phase II (see also breast, etanercept Thousand Oaks, CA (805) 447-1000 colorectal, liver, Wyeth Pharmaceuticals (800) 934-5556 lung, pancreatic, Collegeville, PA prostate, sarcoma) fentanyl INSYS Therapeutics cancer pain Phase III TAS-102 Taiho Pharma USA gastric cancer Phase II sublingual Phoenix, AZ (602) 910-2617 Princeton, NJ (609) 750-5300 spray Tasigna® Novartis GIST Phase III fentanyl Sosei R&D cancer pain Phase I nilotinib Pharmaceuticals (see also leukemia) (888) 669-6682 sublingual Tokyo, Japan (Orphan Drug) East Hanover, NJ (SRSS-001) tesetaxel Genta second-line therapy Phase II fentanyl Lavipharm cancer pain Phase III (Orphan Drug) Berkeley Heights, NJ (see also colorectal) (908) 286-9800 transdermal East Windsor, NJ (609) 448-3001 patch TheraCIM™ YM Biosciences esophageal cancer Phase II ® nimotuzumab Wayne, PA (neoadjuvant therapy) (610) 560-0600 Fosamax Merck bone loss associated Phase II (see also brain, breast, alendronic acid Whitehouse Station, with androgen (800) 672-6372 prostate) NJ deprivation therapy in prostate cancer TNFerade™ GenVec esophageal cancer Phase II Gaithersburg, MD (see also colorectal, completed golotimod SciClone mucositis Phase II head/neck, (240) 632-0740 Pharmaceuticals (prevention) (650) 358-3456 pancreatic, skin) Foster City, CA Tykerb® GlaxoSmithKline gastric cancer Phase III In-111-DAC Naviscan cancer diagnostic Phase I lapatinib Rsch. Triangle Park, (combination therapy) (888) 825-5249 San Diego, CA imaging (858) 587-3641 NC (see also brain, head/neck) LGD-4665 GlaxoSmithKline treatment-induced Phase II Xeloda® Roche esophageal cancer Phase II Rsch. Triangle Park, thrombocytopenia (888) 825-5249 capecitabine Nutley, NJ (see also colorectal) (973) 235-5000 NC XL-880 Exelixis gastric cancer Phase II morphine MDRNA cancer pain Phase II South San Francisco, CA (see also head/neck, (650) 837-7000 intranasal Bothell, WA (425) 908-3600 GlaxoSmithKline kidney) (888) 825-5249 MRX-1024 Molecular Therapeutics mucositis Phase I Rsch. Triangle Park, NC Ann Arbor, MI (734) 259-4574 Nasalfent® Archimedes Pharma cancer pain Phase III Cancer/Chemotherapy-Related Conditions fentanyl Reading, 802-2 Adeona graft-versus-host disease Phase I/II intranasal United Kingdom Pharmaceuticals (734) 332-7800 Neumega® Wyeth Pharmaceuticals chemotherapy-induced Phase II Ann Arbor, MI Collegeville, PA mucositis (800) 934-5556 Acapodene® GTx complications from application graft-versus-host disease Phase I/II toremifene Memphis, TN androgen submitted (800) 934-5556 deprivation therapy (901) 523-9700 Neuprex® XOMA graft-versus-host disease Phase I/II (see also prostate) opebacan Berkeley, CA in patients undergoing (510) 204-7200 acetylcysteine Adherex Technologies chemoprotection Phase I/II allogeneic hematopoetic Durham, NC (919) 484-8484 stem cell transplantation AKR-501 Eisai idiopathic Phase II Nipent® Hospira graft-versus-host disease Phase II/III Woodcliff Lake, NJ thrombocytopenic (888) 422-4743 pentostatin Lake Forest, IL (see also leukemia, (224) 212-2000 purpura lymphoma) Aredia® Novartis cancer pain Phase III NP-2 Diamyd Medical cancer pain Phase I pamidronic acid Pharmaceuticals (see also multiple (888) 669-6682 gene therapy Pittsburgh, PA (412) 770-1310 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 35

35 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

Nplate™ Amgen chemotherapy-induced Phase II Titragesia™ ZARS Pharma cancer pain Phase III romiplostim Thousand Oaks, CA thrombocytopenia (805) 447-1000 fentanyl patch Salt Lake City, UT (801) 350-0202 (see also leukemia) totrombopag GlaxoSmithKline thrombocytopenia Phase I ondansetron MonoSol Rx chemotherapy-and Phase III Rsch. Triangle Park, (888) 825-5249 oral film Warren, NJ radiotherapy- (219) 672-8112 NC Strativa induced nausea (201) 802-4206 Urso Forte™ Axcan Pharma chemoprevention Phase II Pharmaceuticals and vomiting ursodeoxycholic Birmingham, AL (see also colorectal) (205) 991-8085 Woodcliff Lake, NJ acid ondansetron NovaDel Pharma chemotherapy-and Phase III veltuzumab Immunomedics chemotherapy-induced Phase I/II oncology-times.com oral spray Flemington, NJ radiotherapy- (908) 782-3431 (IMMU-106) Morris Plains, NJ immune (973) 605-8200 Strativa Pharmaceuticals induced nausea and (201) 802-4206 thrombocytopenic Woodcliff Lake, NJ vomiting purpura Onsolis™ BioDelivery Sciences cancer pain application (see also lymphoma) fentanyl Morrisville, NC submitted Voraxaze™ Protherics chemoprotection application transmucosal Meda Pharmaceuticals (919) 653-5160 glucarpidase Brentwood, TN submitted Somerset, NJ (615) 327-1027 ® orBec DOR BioPharma graft-versus-host application xaliproden sanofi-aventis chemotherapy-induced Phase III beclometasone Ewing, NJ disease submitted Bridgewater, NJ neuropathies (800) 633-1610 (Orphan Drug) Sigma-Tau (609) 538-8200 ZRx101 ZelleRx graft-versus-host disease Phase I Pharmaceuticals (800) 447-0169 Chicago, IL (see also kidney, (312) 243-5200 Gaithersburg, MD multiple myeloma, skin) graft-versus-host disease Phase II (prevention) (609) 538-8200 Other Cancers (800) 447-0169 3F8 mAb United Therapeutics central nervous system Phase II PF-4383119 Pfizer cancer pain Phase II Silver Spring, MD cancer (see also brain) (301) 608-9292 (tanezumab) New York, NY (860) 732-5156 Å6 Angstrom advanced gynecological Phase I PHY-906 PhytoCeutica chemoprotection Phase I/II Pharmaceuticals cancer (858) 314-2356 New Haven, CT (203) 777-3462 Solana Beach, CA (see also ovarian) Phytosel® iBioPharma chemoprotection Phase I aflibercept sanofi-aventis symptomatic malignant Phase III Newark, DE (302) 355-0650 (VEGF-trap) Bridgewater, NJ ascites (see also (800) 633-1610 PMI-150 Javelin Pharmaceuticals cancer pain Phase III Regeneron colorectal, lung, (914) 345-7400 (ketamine Cambridge, MA (617) 349-4500 Pharmaceuticals pancreatic, prostate) intranasal) Tarrytown, NY ® Prochymal Osiris Therapeutics graft-versus-host disease Phase III AMG 386 Amgen fallopian tube cancer, Phase II human Columbia, MD (443) 545-1800 Thousand Oaks, CA peritoneal cancer (805) 447-1000 mesenchymal (see also breast, kidney, stem cell therapy ovarian, stomach) (Orphan Drug) Armala™ GlaxoSmithKline fallopian tube cancer, Phase II ® Prograf Astellas Pharma US graft-versus-host disease application pazopanib Rsch. Triangle Park, peritoneal cancer (888) 825-5249 Deerfield, IL submitted NC (see also brain, breast, (800) 727-7003 cervical, kidney, liver, Rapamune® Wyeth Pharmaceuticals bone marrow transplant Phase II lung, ovarian, sarcoma) sirolimus Collegeville, PA rejection (see also (800) 934-5556 ARQ-501 ArQule leiomyoma Phase II unspecified) (beta lapachone) Woburn, MA (see also head/neck, (781) 994-0300 Rapinyl™ Orexo breakthrough cancer Phase III pancreatic, solid tumors) fentanyl Uppsala, Sweden pain ATI-BC-1 Algeta bone cancer (metastatic Phase I sublingual ProStrakan Galashiels, Oslo, Norway from hormone- www.algeta.com (EN 3267) United Kingdom refractory prostate Reviroc™ Kiadais Pharma bone marrow transplant Phase II cancer) (Orphan Drug) St. Laurent, Canada rejection (514) 336-4886 atiprimod Callisto carcinoid tumor Phase II graft-versus-host disease Phase I/II Pharmaceuticals (212) 297-0010 (514) 336-4886 New York, NY Sativex® Otsuka America cancer pain Phase II/III Avastin® Genentech fallopian tube cancer, Phase III dronabinol/ Pharmaceutical (800) 562-3974 bevacizumab South San Francisco, peritoneal cancer (650) 225-1000 cannabidiol Rockville, MD CA (see also brain, colorectal, SCH-58500 Schering-Plough myeloablation Phase I head/neck, kidney, liver, (p53 gene Kenilworth, NJ (see also bladder, (908) 298-4000 lung, lymphoma, therapy) head/neck, liver, lung) multiple myeloma, STS Adherex Technologies chemoprotection Phase III ovarian, pancreatic, Durham, NC (919) 484-8484 prostate, stomach) Tavocept™ BioNumerik chemoprotection Phase III axitinib Pfizer New York, NY thyroid cancer Phase II dimesna Pharmaceuticals (210) 614-1701 (see also colorectal, (860) 732-5156 San Antonio, TX kidney,lung, solid Telintra® Telik chemotherapy-induced Phase II tumors) ezatiostat Palo Alto, CA neutropenia (650) 845-7700 AZD6244 AstraZeneca thyroid cancer Phase II (see also leukemia) Wilmington, DE (see also leukemia, (800) 236-9933

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36 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

liver, lung, multiple ING 1 Aduro BioTech adenocarcinoma Phase I myeloma, ovarian, Berkeley, CA (510) 848-4400 pancreatic, skin) MCS110 Novartis bone cancer Phase I/II Azedra™ Molecular Insight neuroendocrine tumors Phase I/II Pharmaceuticals (see also prostate) (888) 669-6682 iodine-labeled Pharmaceuticals (see also brain) (617) 492-5554 East Hanover, NJ metaiodobenzyl- Cambridge, MA MER-101 Merrion bone cancer Phase II guanidine Pharmaceuticals (910) 799-1847 (Orphan Drug) Wilmington, NC Bonefos® Bayer HealthCare cancer metastases application oncology-times.com MK-0646 Merck neuroendocrine tumors Phase II clodronic acid Pharmaceuticals submitted Whitehouse Station, NJ (see also breast, lung, (888) 669-6682 Wayne, NJ (888) 842-2937 pancreatic) BSI-201 BiPar Sciences fallopian tube cancer, Phase II MK-0822 Merck bone cancer Phase III Brisbane, CA peritoneal cancer, (650) 635-6050 Whitehouse Station, NJ completed uterine cancer (800) 672-6372 (see also brain, breast, motesanib Amgen thyroid cancer Phase II ovarian) Thousand Oaks, CA (see also breast, (805) 447-1000 catumaxomab Fresenius Biotech malignant ascites Phase II Millennium colorectal, lung) (800) 390-5663 North America (see also ovarian) www.fresenius- Pharmaceuticals Waltham, MA biotech.com Cambridge, MA CDB-4124 uterine leiomyoma Phase III NBI-42902 Neurocrine Biosciences uterine leiomyoma Phase I The Woodlands, TX (281) 719-3400 San Diego, CA (see also breast, (858) 617-7600 CS-7017 Daiichi Sankyo thyroid cancer Phase I prostate) Parsippany, NJ (see also lung) (973) 359-2600 Norprolac® Ferring Pharmaceuticals prolactinoma Phase II CX-4945 Cylene giant lymph node Phase I quinagolide Suffern, NY www.ferring.com Pharmaceuticals hyperplasia (see also (858) 875-5100 Opaxio™ Cell Therapeutics peritoneal cancer Phase II San Diego, CA multiple myeloma, paclitaxel Seattle, WA (see also lung, ovarian, (800) 215-2355 solid tumors) poliglumex Novartis stomach) (888) 669-6682 D4064A Genentech fallopian tube cancer, Phase I Pharmaceuticals South San Francisco, peritoneal cancer (650) 224-1000 East Hanover, NJ CA (see also ovarian) fallopian tube cancer Phase I/II deforolimus ARIAD endometrial cancer Phase II (800) 215-2355 (MK-8669) Pharmaceuticals (see also breast, lung, (617) 494-0400 (888) 669-6682 Cambridge, MA prostate, sarcoma) (800) 672-6372 pasireotide Novartis neuroendocrine tumors Phase I Merck Pharmaceuticals completed Whitehouse Station, NJ East Hanover, NJ (888) 669-6682 denosumab Amgen prevention of bone Phase III PX-12 Oncothyreon metastatic disease Phase I (AMG 162) Thousand Oaks, CA metastases (see also (805) 447-1000 Seattle, WA (see also pancreatic, (206) 801-2100 multiple myeloma, stomach) cancer-related) Quadramet® Cytogen cancer metastases Phase III DM-CHOC- Dekk-Tec central nervous system Phase I samarium Princeton, NJ (see also multiple (800) 833-3533 PEN New Orleans, LA cancer (504) 583-6135 sm-153 myeloma, prostate, E7080 Eisai thyroid cancer (see also Phase II lexidronam sarcoma) Woodcliff Lake, NJ solid tumors) (888) 422-4743 injection EC-20 Endocyte diagnosis of folate Phase II quarfloxin Cylene Pharmaceuticals neuroendocrine tumors Phase II West Lafayette, IN receptor- (765) 463-7175 San Diego, CA (858) 875-5100 positive cancers RAV-12 Raven Biotechnologies adenocarcinoma Phase I/II EC-145 Endocyte endometrial cancer Phase II South San Francisco, (see also pancreatic) (650) 624-2600 West Lafayette, IN (see also lung, ovarian) (765) 463-7175 CA everolimus Novartis neuroendocrine tumors Phase III relacatib GlaxoSmithKline cancer metastases Phase II Pharmaceuticals (see also kidney, (888) 669-6682 (cathepsin Rsch. Triangle Park, (888) 825-5249 East Hanover, NJ pancreatic) K inhibitor) NC Revlimid® Celgene central nervous system Phase II Herceptin® Genentech salivary gland cancer Phase II lenalidomide Summit, NJ cancer (see also leukemia, (908) 673-9000 trastuzumab South San Francisco, (see also colorectal, (650) 225-1000 lymphoma, multiple CA ovarian, pancreatic, myeloma, prostate) prostate, stomach) saracatinib AstraZeneca metastatic bone cancer Phase II Hycamtin® GlaxoSmithKline uterine cancer (see also Phase II Wilmington, DE (800) 236-9933 topotecan Rsch. Triangle Park, breast, colorectal, (888) 825-5249 NC head/neck, kidney, seliciclib Cyclacel nasopharyngeal cancer Phase II leukemia, lung, Pharmaceuticals (see also lung) (973) 847-5955 lymphoma, multiple Short Hills, NJ myeloma, ovarian, Somatuline Tercica neuroendocrine tumors Phase III pancreatic, prostate, Autogel® Brisbane, CA (650) 624-4900 stomach) lanreotide idronoxil Marshall Edwards fallopian tube cancer Phase I/II Tarceva® Genentech gynecological cancer Phase II North Ryde, Australia (combination therapy) erlotinib South San Francisco, (combination therapy) (650) 224-1000 (see also ovarian, prostate) CA (see also bladder, brain, (800) 572-1932 LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 37

37 Medicines & Vaccines in Development for Cancer (cont.)

Development Development 2009

Product Name Sponsor Indication Status Product Name Sponsor Indication Status •

OSI Pharmaceuticals breast, colorectal, BLX-883 Pittsboro, NC Phase I Melville, NY head/neck, liver, lung) (919) 542-9901 Taxotere® sanofi-aventis pediatric cancer Phase III carbendazim Arisyn Therapeutics Phase I Bridgewater, NJ (800) 633-1610 Frederick, MD (301) 644-3921 V503 Merck vulvovaginal cancer Phase III CLT-001 Cellerant Therapeutics Phase II Whitehouse Station, prevention (800) 672-6372 San Carlos, CA (650) 232-2122 NJ (see also cervical) CNDO-101 Coronado Biosciences Phase I XL-184 Bristol-Myers Squibb medullary thyroid Phase III San Diego, CA (510) 396-5709

Princeton, NJ cancer (see also brain) (212) 546-4000 CPI-613 Cornerstone Phase I oncology-times.com Exelixis Pharmaceuticals (609) 409-7050 South San Francisco, Cranbury, NJ CA EC-0225 Endocyte Phase I ® Yondelis Johnson & Johnson endometrial cancer Phase II West Lafayette, IN (765) 463-7175 trabectedin Pharmaceutical (see also breast, ovarian, (800) 817-5286 ENMD-1198 EntreMed Phase I Research prostate, sarcoma) Rockville, MD (240) 864-2600 & Development Raritan, NJ EZN-2208 Enzon Pharmaceuticals Phase I Bridgewater, NJ (866) 792-5172 Zactima® AstraZeneca medullary thyroid Phase III vandetanib Wilmington, DE cancer (see also brain, (800) 236-9933 F50035 Merck Phase II breast, lung) Whitehouse Station, NJ (800) 672-6372 Pierre Fabre Zybrestat™ OXiGENE thyroid cancer Phase II/III Medicament Castres, fosbretabulin Waltham, MA (combination therapy) (781) 547-5900 France (Orphan Drug) (see also head/neck, lung, ovarian) Fibrovax™ PharmaSciences Phase I cancer vaccine King of Prussia, PA (610) 687-1776 Unspecified Cancers GPX-150 Gem Pharmaceuticals Phase I/II (drugs that have potential for one or more of the previous cancers) Birmingham, AL (205) 982-0320 1059615 GlaxoSmithKline Phase I HuCAL fully Centocor Horsham, PA Phase I Rsch. Triangle Park, (888) 825-5249 human antibody MorphoSys Martinsried, (610) 651-6000 NC Germany 1120212 GlaxoSmithKline Phase I IAP antagonist Genentech Phase I Rsch. Triangle Park, NC (888) 825-5249 South San Francisco, CA (650) 224-1000 AFX-9901 Afecta Pharmaceuticals in clinical trials IMC-18F1 ImClone Systems Phase I Irvine, CA (949) 253-4688 New York, NY (212) 645-1405 AG-24322 Pfizer Phase I Imprime Biothera Eagen, MN Phase I New York, NY (860) 732-5156 PGG™ (651) 675-0300 AGS-16M18 Agensys Phase I JNJ-26483327 Johnson & Johnson in clinical trials Santa Monica, CA (310) 820-8029 Pharmaceutical Research (800) 817-5286 Astellas Pharma US (800) 477-6472 & Development Deerfield, IL Raritan, NJ ALT-801 Altor BioScience Phase I/II KX2-391 Kinex Pharmaceuticals Phase I Miramar, FL (954) 443-8600 Buffalo, NY (716) 881-8984 anti-HGF mAb Schering-Plough Phase I LBY135 Novartis Pharmaceuticals Phase I Kenilworth, NJ (908) 298-4000 East Hanover, NJ (888) 669-6682 ANX-514 ADVENTRX Phase I LOR-2501 Lorus Therapeutics Phase I (docetaxel Pharmaceuticals (858) 552-0866 Toronto, Canada (416) 798-1200 emulsion) San Diego, CA LR-103 Genzyme Phase I ARRY-300 Array BioPharma Phase I Cambridge, MA (617) 252-7500 Boulder, CO (303) 381-6600 LY2157299 Eli Lilly Phase I ARRY-380 Array BioPharma Phase I Indianapolis, IN (800) 545-5979 Boulder, CO (303) 381-6600 LY2603618 Eli Lilly Phase I ARRY-614 Array BioPharma Phase I Indianapolis, IN (800) 545-5979 Boulder, CO (303) 381-6600 MK-2461 Merck Phase I/II AVR-118 Advanced Viral Phase II Whitehouse Station, NJ (800) 672-6372 Research Yonkers, NY (914) 376-7383 MK-4101 Merck Phase I ALZA Phase I Whitehouse Station, NJ (800) 672-6372 Mountain View, CA (650) 564-5000 MK-8033 Merck Phase I BIO-109 Evolve Oncology Phase II Whitehouse Station, NJ (800) 672-6372 New York, NY (646) 723-8941 MKI833 Wyeth Phase 0 BIO-113 Evolve Oncology Phase II Pharmaceuticals (800) 934-5556 New York, NY (646) 723-8941 Collegeville, PA BIO-121 Evolve Oncology Phase I NRX-4204 NuRx Pharmaceuticals Phase I New York, NY (646) 723-8941 Irvine, CA (949) 336-7111 BIO-128 Evolve Oncology Phase I OSI-7904L OncoVista Phase II New York, NY (646) 723-8941 San Antonio, TX (210) 677-6000

continued on next page LWW-OTUS_APR10-09-0301-DrugChart-PNK.qxp 4/24/09 7:07 PM Page 38

38 Medicines & Vaccines in Development for Cancer (cont.)

2009 Development Development

• Product Name Sponsor Indication Status Product Name Sponsor Indication Status

Mebiopharm Phase I R306465 Johnson & Johnson Phase I liposomal Tokyo, Japan www.mebio Pharmaceutical (800) 817-5286 pharm.com Research & PBI-05204 Phoenix Biotechnology Phase I Development San Antonio, TX (877) 593-8945 Raritan, NJ ® PCI-27483 Pharmacyclics Phase I Rapamune Wyeth Pharmaceuticals (see also cancer- Phase I Sunnyvale, CA (408) 774-0330 sirolimus Collegeville, PA related) (800) 934-5556 PF-337210 Pfizer Phase I RDEA-119 Ardea Biosciences Phase I/II San Diego, CA (858) 652-6500 oncology-times.com New York, NY (860) 732-5156 PF-562271 Pfizer Phase I RDEA-436 Ardea Biosciences Phase 0 New York, NY (860) 732-5156 San Diego, CA (858) 652-6500 PF-2341066 Pfizer Phase I SJG-136 Ipsen Phase I New York, NY (860) 732-5156 Milford, MA (508) 478-8900 PF-3084014 Pfizer Phase I SNX-5422 Serenex Phase I New York, NY (860) 732-5156 Durham, NC (919) 281-6001 PF-3446962 Pfizer Phase I SRT-501 Sirtris Pharmaceuticals Phase II New York, NY (860) 732-5156 Cambridge, MA (617) 252-6920 PF-3732010 Pfizer Phase I TAK-285 Millennium Phase I New York, NY (860) 732-5156 Pharmaceuticals (800) 390-5663 PF-4217903 Pfizer Phase I Cambridge, MA New York, NY (860) 732-5156 taltobulin Wyeth Phase I PF-4554878 Pfizer Phase I Pharmaceuticals (800) 934-5556 New York, NY (860) 732-5156 Collegeville, PA PF-4856884 Pfizer Phase I TRC-102 TRACON Phase I (CovX060) New York, NY (860) 732-5156 Pharmaceuticals (858) 550-0780 PF-4929113 Pfizer Phase I San Diego, CA New York, NY (860) 732-5156 TRC-105 TRACON Phase I PHA-848125 Nerviano Phase I Pharmaceuticals (858) 550-0780 Medical Sciences www. San Diego, CA Nerviano, Italy nervianoms.com V930 Merck Phase I plasmid DNA Merck Phase I (cancer vaccine) Whitehouse Station, NJ (800) 672-6372 cancer vaccine Whitehouse Station, NJ (800) 672-6372 Vical (858) 646-1100 Vical San Diego, CA (858) 646-1100 San Diego, CA QBI-139 Quintessence Biosciences Phase I VTX-2337 VentiRx Pharmaceuticals Phase I Madison, WI (608) 441-2950 San Diego, CA (858) 436-1530