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Jefferies 2013 Global Healthcare Conference in London

At the 2012 Jefferies Global Healthcare Conference, there were well over 200

healthcare companies participating with a combined market cap of $1 trillion and close to 1,300 one-on-one/small group meetings over the two-day event. The 2013 conference is set to follow the same footsteps, featuring public and private leading INVITATION global healthcare companies within the areas of pharmaceuticals, biotech, generics, 20-21 NOVEMBER 2013 medtech and healthcare services from the US, Central and Eastern Europe, Latin

The Waldorf Hilton America, India, China, Japan, Egypt, Israel and Russia. London, UK Throughout the two-day event, we will feature concurrent tracks of informative presentations as well as 1x1/small group meetings, and thematic panel discussions. This global gathering of institutional investors, private equity investors, VCs and leading executives will address near- and long-term investment opportunities and discuss the mechanisms driving global healthcare.

We hope you can join us for what promises to be a unique and comprehensive view of the industry.

Registration is now open. Please email your Jefferies representative if you are interested in attending.

For general questions, please email [email protected] or contact your Jefferies representative.

© 2013 Jefferies LLC. Member SIPC.

AGENDA WEDNESDAY, 20 NOVEMBER 2013 Jefferies 2013 Global Healthcare Conference in London

ADELPHI 1 ADELPHI 2 ADELPHI 3 EXECUTIVE BOARDROOM 7:30 AM Breakfast & Registration

8:00 AM Clinigen Group Plc Ion Beam Applications Active Biotech AB Syneron Medical Ltd. Specialty Pharma & Healthcare Services Medical Products Biotechnology Medical Technology Paul Thomas; CTO Olivier Legrain, CEO Tomas Leanderson; President and CEO Hugo Goldman, CFO

8:40 AM Valneva Celltrion, Inc. Array BioPharma, Inc. Polpharma S.A. Biotechnology Pharmaceuticals Biotechnology Pharmaceuticals Reinhard Kandera, CFO Alex Kudrin, Vice President, Product Ron Squarer, CEO Piotr Hrycaj; M&A Director Development Division

9:20 AM Seattle Genetics Inc. Mallinckrodt H. Lundbeck A/S Hyperion Therapeutics, Inc. Biotechnology Pharmaceuticals Pharmaceuticals Biotechnology Clay Siegall; President and CEO Mark Trudeau; CEO & Matthew Harbaugh, Anders Göetzsche; CFO Donald Santel; CEO Senior VP and CFO

10:00 AM IMS Healthcare Incorporated Synageva BioPharma Corp Farmak JSC Optos PLC Healthcare Services Biotechnology Pharmaceuticals Medical Technology Stefan Linn; SVP Global Pharma Sang Patel; President & CEO Filya Zhebrovska; Chairman and CEO Roy Davis; CEO

10:40 AM Novo Nordisk A/S Alere Inc. Cosmo Pharmaceuticals SpA Pharmaceuticals Pharmaceuticals Biotechnology Biotechnology Ian Page; CEO & Anne-Francoise Nesmes, CFO Lars Borup Jacobsen; Manager of IR Jon Russell; Vice President Finance Chris Tanner; CFO and Head of IR

11:20 AM Amplifon SpA Lonza Group AG Swedish Orphan Biovitrum AB AMCo Healthcare Services Biotechnology Biotechnology Pharmaceuticals Ugo Giorcelli; CFO Toralf Haag; CFO Geoffrey McDonough; CEO John Beighton; CEO

12:00 PM Break – Working Lunch

Presenting companies and speakers are subject to change. AGENDA WEDNESDAY, 20 NOVEMBER 2013 Jefferies 2013 Global Healthcare Conference in London

ADELPHI 1 ADELPHI 2 ADELPHI 3 EXECUTIVE BOARDROOM

12:20 PM Consort Medical Plc Kadmon Corporation Panel – Changing Pharma Business Models Martindale Pharmaceuticals Ltd. Medical Technology Biotechnology Mark Trudeau, CEO, Mallinckrodt Pharmaceuticals Jonathan Glenn; CEO Samuel Waksal; Chairman & CEO Peter Stein, CEO, Norgine Richard de Souza; CEO Hakan Bjorklund, former CEO, Nycomed Vassilios Katsos, CEO, Pharmathen Dr. Michael Mehler, CEO, Riemser

1:00 PM Galenica Ltd. Orpea S.A. Novozymes A/S Cempra, Inc. Pharmaceuticals Healthcare Services Pharmaceuticals Pharmaceuticals Fritz Hirsbrunner; Head of IR Steve Grobet; IR Dave Mead, Business Development Director Prabhavathi Fernandes; President and CEO

1:40 PM Al Noor Hospitals Group Plc PAREXEL International Corporation Lexicon Pharmaceuticals, Inc. Norgine Healthcare Services Healthcare Services Biotechnology Pharmaceuticals Sami Alom; Chief Strategy Officer & Director, IR James Winschel; Jeff Wade; CFO & Brian Zambrowicz, EVP and Peter Stein; CEO Executive Vice President and CFO CSO

2:20 PM BTG Plc Medivation, Inc. ALK-Abello Cell Therapeutics Inc. Biotechnology Biotechnology Pharmaceuticals Biotechnology Louise Makin; CEO David Hung (MD); President & CEO Jens Bager; President and CEO James Bianco; President and CEO

3:00 PM Plc Medical Properties Trust Galapagos NV Alvogen Group Pharmaceuticals Healthcare Services Biotechnology Pharmaceuticals Christopher Blackwell; CEO Edward K. Alda-George, Jr.; Chairman, President Guillaume Jetten; CFO Kevin Bain; CFO & CEO and Richard S. Hamner, EVP and CFO

3:40 PM Enzymotec, Ltd. Ipsen S.A. NMC Health Plc Epizyme, Inc. Biotechnology Pharmaceuticals Healthcare Services Biotechnology Ariel Katz, CEO Susheel Surpal; EVP Finance & CFO & Roy Cherry; Head of Strategy and IR Jason Rhodes; CFO Claude Bertand CSO

4:20 PM ThromboGenics NV Bavarian Nordic A/S Gerresheimer AG Biocon Ltd. (Syngene International) Biotechnology Biotechnology Medical Technology Healthcare Services Patrick De Haes, CEO Anders Hedegaard; President and CEO Anke Linnartz; Director IR Peter Bains; Director

5:00 PM Zealand Pharma A/S NewLink Genetics Corporation Osmotica Pharmaceutical Esteve Biotechnology Biotechnology Pharmaceuticals Pharmaceuticals David Solomon; President and CEO Gordon Link; CFO Praveen Tyle; President and CEO Mark Mayhew; Head of Strategic Development for Pharma

Presenting companies and speakers are subject to change. AGENDA THURSDAY, 21 NOVEMBER 2013 Jefferies 2013 Global Healthcare Conference in London

ADELPHI 1 ADELPHI 2 ADELPHI 3 EXECUTIVE BOARDROOM 7:30 AM Breakfast & Registration

8:00 AM GW Pharmaceuticals Transgene SA Biotest AG AMAG Pharmaceuticals, Inc. Pharmaceuticals Biotechnology Biotechnology Biotechnology Justin Gover; CEO Stephane Boissel, CFO Professor Dr. Gregor Schulz; CEO & Michael Frank Thomas, COO Ramroth, CFO

8:40 AM Intercept Pharmaceuticals, Inc. Varian Medical Systems Inc. NPS Pharmaceuticals Inc. Helsinn Healthcare SA Pharmaceuticals Medical Technology Biotechnology Pharmaceuticals Barbara Duncan; CFO Neil Madle; Director, IR Francois Nader; President and CEO Roberto De Ponti; Head of Corporate BD

9:20 AM Cipla Ltd. Pacira Pharmaceuticals Inc. BioMarin Pharmaceutical Inc. Valenta Pharmaceuticals JSC Pharmaceuticals Pharmaceuticals Biotechnology Pharmaceuticals Subhanu Saxena; CEO & Rajesh Garg CFO Dave Stack; President & CEO Jean-Jacques Bienaime; CEO Sergei Zaiats; Director of Strategic Products

10:00 AM Aratana Therapeutics, Inc. Covidien plc Aegerion Pharmaceuticals, Inc. Antares Pharma Inc. Pharmaceuticals Medical Technology Biotechnology Pharmaceuticals Steven St. Peter, President and CEO Cole Lannum, VP of Investor Relations Mark Fitzpatrick; CFO Paul Wotton; President and CEO

10:40 AM Smith & Nephew plc AbbVie Inc. PDL BioPharma, Inc. Putney, Inc. Medical Technology Pharmaceuticals Biotechnology Pharmaceuticals Julie Brown; CFO Scott Brun; Vice President, John P. McLaughlin; President and CEO Jean Hoffman; President & CEO Pharmaceutical Development

11:20 AM Actelion Ltd. AG Henry Schein, Inc. Ethypharm SA Biotechnology Pharmaceuticals Healthcare Services Pharmaceuticals Otto Schwarz; COO Harry Kirsch; CFO Ferdinand Jahnel, Vice President, Treasurer Hugues Lecat; CEO and Chairman

12:00 PM Break – Working Lunch

Presenting companies and speakers are subject to change. AGENDA THURSDAY, 21 NOVEMBER 2013 Jefferies 2013 Global Healthcare Conference in London

ADELPHI 1 ADELPHI 2 ADELPHI 3 EXECUTIVE BOARDROOM 12:20 PM Ambu A/S Targacept, Inc. Panel – Biosimilar Antibodies Orexo AB Medical Technology Biotechnology 1. Michael Kotsanis, COO, Synthon Biotechnology Lars Marcher; President and CEO Dr. Stephen A. Hill; President and CEO 2. Raymond de Vrie – SVP, Commercial Biologics, Nikolaj Sorensen; CEO Dr. Reddy's 3. Dr. Udo Hartlaub – Head of Global Regulatory Affairs Biosimilars,Teva 4. Richard DiCicco – Chairman, Harvest Moon Pharmaceuticals 5. Marwood Group 6. IMS

1:00 PM UDG Healthcare Plc Arseus NV Morphosys AG Durata Therapeutics Healthcare Services Healthcare Services Biotechnology Pharmaceuticals Liam Fitzgerald, CEO Ger van Jeveren; CEO Jens Holstein; CFO Paul Edick; CEO

1:40 PM Recordati SpA ImmunoGen, Inc. Genmab AS Pharmathen S.A. Pharmaceuticals Biotechnology Biotechnology Pharmaceuticals Fritz Squindo, CFO Charles Morris; EVP and Jan van de Winkel; President and CEO Vassilios Katsos; President and CEO Chief Development Officer

2:20 PM Eurofins Scientific SA Gulf Pharmaceuticals Industries (Julphar) Haemonetics Corp Zeltia SA Medical Technology Pharmaceuticals Medical Technology Biotechnology Dr. Gilles Martin, Chairman and CEO GVG Krishna, CFO Christopher Lindop, CFO & Michael Kelly; Dr. José María Fernandez; President, Global Markets Chairman group Zeltia

3:00 PM GN Store Nord A/S Sanofi Verastem Symetis SA Medical Technology Pharmaceuticals Pharmaceuticals Medical Technology Lars Viksmoen, CEO Sebastien Martel; VP & Head of IR Robert Forrester; President & CEO Jacques Essinger; CEO

3:40 PM Stratec Biomedical AG Kamada Ltd. Sartorius AG Synthon Holdings B.V. Biotechnology Biotechnology Medical Technology Pharmaceuticals Marcus Wolfinger; Chairman, Gil Efron, CFO & Pnina Strauss, Vice President Joerg Pfirrmann; CFO Michael Kotsanis; CCO Board of Management Clinical Development and iP

4:20 PM Priory Group Symmetry Medical Inc. Prosensa Holding N.V. RIEMSER Pharma GmbH Healthcare Services Medical Technology Biotechnology Pharmaceuticals Tom Riall; CEO Thomas Sullivan; President and CEO Hans Schikan; CEO Michael Mehler; CEO

5:00 PM Lombard Medical Technologies Pluristem Therapeutics, Inc. Ablynx NV Ambrx, Inc. Medical Technology Biotechnology Biotechnology Biotechnology Ian Ardill, CFO Zami Aberman, Chairman and CEO Edwin Moses; Chairman and CEO Lawson Macartney, CEO

Presenting companies and speakers are subject to change. PARTICIPATING

COMPANIES Jefferies 2013 Global Healthcare Conference in London

Participating Companies as of 11/04/2013

• AB Science SA • Cell Therapeutics, Inc. • Ipsen S.A. • AbbVie Inc. • Celltrion Inc • Kadmon Pharmaceuticals • Ablynx NV • Cempra, Inc. • Kamada Ltd. • Acino Holding AG • Chemo Group • Kedrion S.p.A. • Actelion Ltd. • Cipla Ltd. • Lexicon Pharmaceuticals, Inc. • Active Biotech AB • Consort Medical Plc. • Lombard Medical Technologies • Aegerion Pharmaceuticals, Inc. • Cosmo Pharmaceuticals SpA • Lonza Group AG • Affimed Therapeutics AG • Covidien plc • Mallinckrodt Plc • Al Noor Hospitals Group Plc • Dechra Pharmaceuticals • Martindale Pharma • Aldagi Insurance Co. • Durata Therapeutics, Inc. • Marwood Group LLC • Alere Inc. • Egis Pharmaceuticals Plc • MD Medical Group Investments Plc • Alexza Pharmaceuticals Inc. • Enzymotec, Ltd. • Medical Properties Trust • ALK-Abello • Epizyme, Inc. • Medivation, Inc. • Almirall, S.A. • Esteve • Medivir AB • Alvogen Group • Ethypharm SA • Merck & Co. Inc. • AMAG Pharmaceuticals, Inc. • Eurofins Scientific SA • Morphosys AG • Ambrx, Inc • Farmak JSC • NewLink Genetics Corporation • Ambu A/S • Galapagos NV • Nicox SA • AMCo • Galenica Ltd. • NMC Health Plc. • Amplifon SpA • Genmab AS • Norgine • Antares Pharma Inc. • Gerresheimer AG • Novartis AG • Aratana Therapeutics, Inc. • GN Store Nord A/S • Novo Nordisk A/S • Array BioPharma, Inc. • GW Pharmaceuticals • Novozymes A/S • Arrowhead Research Corporation • H. Lundbeck A/S • NPS Pharmaceuticals Inc. • Arseus NV • Haemonetics Corp • Olainfarm • AVANIR Pharmaceuticals • Helsinn Healthcare SA • Optos Plc • Basilea Pharmaceutica AG • Henry Schein, Inc. • Orexo AB • Bavarian Nordic A/S • plc • Orpea S.A. • Biocon Ltd (Syngene International) • Hyperion Therapeutics, Inc. • Osmotica Pharmaceutical • BioMarin Pharmaceutical Inc. • ImmunoGen, Inc. • Oxford BioMedica PLC • Biotest AG • IMS Healthcare Incorporated • Oxford Nanopore Technologies Ltd. • Brace Pharmaceuticals, Inc. EMS S/A • Intercept Pharmaceuticals, Inc. • Pacira Pharmaceuticals Inc. • BTG Plc • Ion Beam Applications • Paras Biopharmaceuticals Limited

Presenting companies are subject to change. PARTICIPATING

COMPANIES Jefferies 2013 Global Healthcare Conference in London

• PAREXEL International Corporation • Rhoen Klinikum AG • Syneron Medical Ltd. • PDL BioPharma, Inc. • RIEMSER Pharma GmbH • Synthon Holding BV • Pharmathen S.A. • Sanofi • Targacept, Inc. • PhotoCure ASA • Sartorius AG • ThromboGenics NV • Pluristem Therapeutics, Inc. • Seattle Genetics Inc • Transgene SA • Polpharma S.A. • Shire plc • UDG Healthcare plc • Priory Group • Sinclair Pharma Plc • Valenta Pharmaceuticals JSC • Prosensa Holding N.V. • Smith & Nephew plc • Valneva • Putney, Inc. • Sphere Medical Holding PLC • Varian Medical Systems Inc. • Recordati SpA • Stratec Biomedical AG • Vectura Group Plc • Swedish Orphan Biovitrum AB • Verastem, Inc. • Symetis SA • Zealand Pharma A/S • Symmetry Medical Inc. • Zeltia SA • Synageva BioPharma Corp

Presenting companies are subject to change.