Which Enzyme Product Is Right for You?

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Enzyme Dosing What are Enzymes? Enzyme Quick Facts: Which Enzyme Product The amount of enzyme taken in a dose Enzymes are specialized proteins that is Right for You? is dependent upon the amount eaten, not accelerate biochemical reactions. The • Enzymes break down proteins, age or body weight. The more enzyme enzyme itself does not change during carbs and fats. Devin Houston, Ph.D. taken, the faster the food is broken down. the reaction, but changes one compound Experimentation with dosing is encouraged (known as the “substrate”) into another • Enzymes are safe in long-term use. Don’t know where to start? to find the optimal dose for your diet. (known as the “product”). If unsure as to which enzyme product is needed, use a • Enzymes are effective for children broad-spectrum formula such as Zyme Prime or TriEnza. Optimal dosing time is usually before or at Digestive enzymes include: as well as adults. Enzyme Products Formulated by the beginning of the meal, so that maximal • proteases/peptidases– Dr. Devin Houston, PhD Biochemist Adjusting to Zyme Prime is not difficult. Zyme Prime is mild contact time between enzymes and food break down proteins/peptides • Enzymes may be an alternative to and low in protease (protein digesting enzymes). Zyme Prime can occur. However, you may take the • carbohydrases– some special diets, such as GFCF should not cause discomfort and is an excellent starter product for the sensitive gut. enzymes at any point during the meal break down carbohydrates and SCD. or soon after and still obtain the • lipases– If desired results are not observed using Zyme Prime, either majority of benefits. break down triglyceride fats • Take enzymes near the beginning increase the dose, add another product (AFP-Peptizyde or of every meal. No-Fenol) or switch to TriEnza. To begin, give enzymes with only 1 meal Proteins are degraded to peptides and is a broad-spectrum product, containing enzymes per day for a few days. Increase gradually amino acids, carbohydrates to sugars, TriEnza • Available in capsules, chewable from until you are taking a full dose with every and triglycerides to fatty acids by breaking tablets and powder. AFP-Peptizyde for proteins, enzymes from Zyme Prime for meal. More can be taken for those foods specific chemical bonds within the compound. fats & carbohydrates, and ½ the xylanase from No-Fenol for that cause dietary problems such as bloating, • Houston Enzymes is the only certain fruits and vegetables. TriEnza is higher in proteases gas, heaviness, etc. Most dietary enzyme supplements are company with the formulation than Zyme Prime. TriEnza has DPP IV activity, unlike Zyme derived from plants such as papaya, expertise of a PhD enzyme biochemist. Prime and, like AFP-Peptizyde, may be an alternative to the What happens if I take an enzyme pineapple, and Aspergillus fungi. The Gluten-Free, Casein-Free (GFCF) diet. supplement and don’t eat? enzymes derived from Aspergillus have Recommended dosing for TriEnza is 1 or 2 capsules Nothing. An enzyme is specific for one been purified from the fungal matter using with meals. substance; if that substance is not from 8 to 12 different methods of purification. present, the enzyme does nothing and simply continues along the digestive tract, No fungal matter is present in our enzyme eventually being degraded by enzymes in products. If you have a known allergy to the GI tract. Aspergillus proteins, then caution should be used in taking any fungal-derived Dosing chart for starting slowly is at enzyme product, however, the allergenic Considering the Gluten-Free, Loose stools, low weight, picky product than Zyme Prime for those with http://www.houston-enzymes.com/dosing. For Frequently Asked Questions and occasional constipation. No-Fenol may be portions of Aspergillus are usually those Casein-Free Diet? eater, carb craver, gas & bloating? added to any other enzyme product to lessen parts of the fungi removed from the Articles on Getting Started, Mixing any stool-firming tendencies. Enzymes, and Giving at School Many of our customers use the Gluten-Free, For concerns like loose stools, low weight, enzymes during processing. picky eater, or carb craver, consider using Mixing Enzymes Casein-Free (GFCF) diet for their children with Red cheeks and/or ears after special needs. If the parent complains about Zyme Prime or ZyCarb. eating certain fruits? Enzymes gradually lose their activity level Plant enzymes are stable in acidic conditions, Visit us online at the difficulty of doing the diet, or the child is once mixed in liquid or food. You can keep and begin to break down food while it is still wanting more freedom to eat “like his friends”, Zyme Prime is excellent for firming stools and breaking down carbohydrates. ZyCarb is similar, This can be a phenolic intolerance that may in the stomach. www.houston-enzymes.com or the parent wishes to improve gluten- and enzymes “good” longer by putting them in a but less firming. be helped by using No-Fenol. casein-connected behaviors, then consider the cold drink, up to about four hours. Enzymes Need help? may be kept in a frozen drink for use later. high-protease AFP-Peptizyde. One capsule Food-related intolerances? “Shiners” under the eyes may also be an Quality Standards Call toll free 866-757-8627 or contains very potent quantities of DPP IV indicator that phenolic foods are a problem. email [email protected]. peptidase plus additional proteases. Foods may break down quickly when mixed Skin rashes and rough patches on elbows while Our enzyme products meet the quality not restricting dietary gluten may be indicators Fats or oils causing digestive with enzymes. Nut butters and cooled standards established by the U.S. AFP-Peptizyde was one of our original products of gluten intolerance. Better digestion of gluten discomfort? chocolates are better choices for preserving invented as an alternative for the GFCF diet. can be accomplished through the use of enzymes for later use. The oil in nut butters Food and Drug Administration’s ruling P.O. Box 6331 AFP-Peptizyde and TriEnza are high-protease, protease enzymes. for current good manufacturing Lypazyme is formulated to help break down and chocolate helps to keep the enzymes Siloam Springs, AR USA 72761 with high DPP IV activity. TriEnza is a newer triglyceride fats while still in the stomach. Faster AFP-Peptizyde (or TriEnza) is recommended. encapsulated. Enzymes mixed with foods practices (CGMPs). This means Telephone: 866-757-8627 combination product, but requires 2 capsules fat breakdown prevents the delay in stomach may be frozen for about two weeks. Enzymes our enzymes are manufactured Fax: 479-549-4540 to equal the protease activity of one emptying usually associated with high-fat meals. AFP-Peptizyde capsule. Is Constipation a Problem? remain active up to about 125-130 degrees consistently as to identity, purity, [email protected] Lypazyme is helpful when supplementing with If so, avoid using Zyme Prime alone, as it fish oils and other sources of beneficial fats. Fahrenheit, but higher temperatures will strength, and composition. Best to start these high-protease products with inactivate them. Enzymes can be added decreases the fecal mass and firms the stool. low and slow dosing. If the child is already on As with any supplement, results can vary to foods after cooking, just prior to serving. These statements have not been evaluated If this is an issue, try adding the No-Fenol the GFCF diet, the parent should not change the product as it reduces stool firmness. with the individual and there is always the Enzymes are not harmed at all by cold by the FDA. These products are not intended diet until fully adjusted to enzymes. to diagnose, cure, treat, or prevent any exception. But most can use the above as a temperatures, in fact; the colder enzymes No-Fenol breaks down fiber which may help disease. Peptizyde™ is a trademark of guide for starting enzymes. The great thing are kept, the longer they keep their activity. These products are not used for celiac disease. soften the stool. No-Fenol can be used alone Houston Nutraceuticals, Inc. about enzymes is that they are not harmful No enzyme product is available for celiac or in combination with other enzyme products at any level of dosing, so you can experiment to counter their stool-firming tendencies. disease, or for “cheating” on a celiac diet, to find the best combination for your in any form. particular needs. © Copyright 2015 ZyCarb, which contains the enzymes found Houston Nutraceuticals, Inc in Zyme Prime plus xylanase, may be a better REV. 2/2015 TriEnza AFP-PeptizydeTM Zyme Prime ZyCarb No-Fenol Lypazyme

• Combination of • Concentrated to • Better digestion • Digestion of carbs • Better breakdown • Support digestion AFP-Peptizyde, digest proteins of carbs & fats & fats with less of fruits and of triglyceride fats y e Zyme Prime • Contains DPP IV enzyme • Great for lactose stool-firming vegetables • Multiple types & No-Fenol for exorphin peptides intolerance • Xylanase for phenolic • Digests phenolic of lipase enzymes foods foods • Helps gas and • Broad-spectrum • Increases breakdown • Helps gas and bloating • Great for lactose • May soften stools bloating from fats • Contains DPP IV • Tends to firm stools of casein, gluten, and intolerance and oils enzyme for exorphin soy proteins • Helps gas and bloating peptides

TriEnza is an economical combination of AFP-Peptizyde™ is an Advanced Formula Zyme Prime is targeted for carbs and fats. ZyCarb excels at carbohydrate digestion No-Fenol helps the digestion of fruits Lypazyme is a potent combination of our best enzymes. Two capsules of TriEnza Protease (AFP) version of our original While not as potent for proteins as with less firming of stools than Zyme Prime. and vegetables without the problems 3 different lipase enzymes. Lypazyme is contain a blend of 1 capsule AFP-Peptizyde, Peptizyde™ for gluten, casein, soy and other AFP-Peptizyde, this formula excels for Contains lactase for dairy lactose digestion, thought to be associated with polyphenolic unique in the use of multiple forms of lipase 1 Zyme Prime and 1/2 capsule No-Fenol and amylase and other carbohydrases for compounds. All plants contain some degree proteins. AFP-Peptizyde is a lower odor/taste carbohydrate digestion. Contains protease to ensure complete breakdown of the (xylanase). TriEnza aids in digestion of food for proteins, lactase for dairy lactose, better starch digestion. ZyCarb reduces of phenolic compounds, which are essential formula with no loss in protein-degrading triglyceride fats found in foods and many proteins; including gluten, casein, and soy; and amylase and other carbohydrases bloating and gas caused by lactose to many of life’s processes. power. The enzymes are derived from fungi; starches; carbohydrates; sugars for better starch digestion. intolerance, beans, broccoli, etc. Contains supplements. Using only one type of (including lactose); fats. no fungal matter is present in the product. lipase to aid in digestion of triglyceride fats. No-Fenol may help with tolerance of phenolic lipase may result in formation of mono- and Reduces bloating and gas caused by ZyCarb has some protease to breakdown foods such as tomatoes, apples, grapes, diglycerides rather than complete breakdown TriEnza contains DPP IV (dipeptidyl peptidase AFP-Peptizyde contains DPP IV (dipeptidyl beans, broccoli, etc. Has lipase to help proteins, though not as potent for proteins berries and citrus. In some cases, tolerance into beneficial short-chain fatty acids. IV), the only enzyme known to break down peptidase IV), the only enzyme known to aid in digestion of triglyceride fats. as AFP-Peptizyde. to artificial colorings and flavors was increased. casomorphin (from casein) and gluteomorphin break down casomorphin and gluteomorphin. Firms up loose stools. No-Fenol breaks down plant fiber and (from gluten). TriEnza is safe with no toxicity promotes a suitable environment for Plant-derived lipase is resistant to stomach Working only on food proteins, AFP-Peptizyde The xylanase in ZyCarb helps digest fruits demonstrated at any dosing level. Other and vegetables without the problems thought the growth of helpful gut bacteria. acid and protease activity which means that is safe with no toxicity demonstrated at any Recommended Use enzymes and supplements may be given to be associated with polyphenolic compounds. No-Fenol may make stools softer fat breakdown can begin in the stomach. 1 to 3 capsules or 2 to 6 chewables with TriEnza. No added cellulase enzyme dosing level. Other enzymes, supplements (see Recommended Use). are sufficient to help with most meals. All plants contain some degree of phenolic Lipase can help with the gas and bloating minimizes interference with timed-release and medications may be given with Decrease dose if constipation occurs – compounds, which are essential to many from high-fat meals and supplements. medications. AFP-Peptizyde. No-Fenol contains Zyphenase™; a proprietary or add No-Fenol. of life’s processes. ZyCarb may help digest blend of xylanase, hemicellulase, glucanase, phenolic foods such as tomatoes, apples, Recommended Use Recommended Use grapes, berries and citrus. ZyCarb breaks and phytase. Recommended Use Serving Size: 1 Capsule or 1 to 2 capsules per meal as needed. 2 capsules or 4 chewable tablets or 1 to 2 capsules or 2 to 6 chewables down plant fiber and promotes an environment 2 Chewable Tablets 1/4 teaspoon powder usually suffices for usually suffice for most meals. More may for the growth of helpful gut bacteria. Recommended Use Serving Size: 1 Capsule most meals. More may be given as needed. be given as needed. ½ to 1 capsule or 1 to 2 chewables Lipase 1...... 250 FIP Amylase ...... 12,000 DU Recommended Use usually suffice for most meals. Decrease May be used as an alternative to the Lipase 2...... 600 FIP May be used as an alternative to the Protease 4.5 ...... 40,000 HUT 1 to 3 capsules are sufficient to help with if stools become too soft, or add Zyme gluten-free/casein-free diet (GFCF). Lipase 3...... 150 FIP gluten-free/casein-free diet (GFCF). Glucoamylase...... 25 AGU most meals. Prime. No-Fenol contains higher amounts of cellulase, which may interfere with ______Serving Size: 2 Capsules or 4 Chewable Serving Size: 1 Capsule or Alpha-Galactosidase...... 200 GalU CereCalase®...... 400 MU Serving Size: 1 Capsule sustained release medications that use Tablets or 1/4 teaspoon Powder 2-3 Chewable Tablets Total Units Lipase Activity...... 1,000 FIP Lactase ...... 1,500 ALU cellulose, hydroxypropyl cellulose, Amylase...... 8,000 DU and /or hypromellose as part of the Peptidase with DPP IV...... 50,000 HUT Peptidase with DPP IV...... 50,000 HUT Lipase...... 200 FCCLU (500 FIP) Glucoamylase...... 50 AGU Other Ingredients: Vegetable cellulose and timed-release mechanism. water. DPP...... IV 1,200 DPPU DPP...... IV 1,200 DPPU Alpha-galactosidase...... 200 GalU CereCalase® contains hemicellulase, beta-glucanase Protease 4.5...... 65,000 HUT Protease 4.5...... 25,000 HUT Lactase ...... 1,500 ALU and phytase, and is a registered trademark of Na- Use No-Fenol for foods that may be high Protease 6.0...... 25,000 HUT Protease 6.0...... 25,000 HUT HN007-120………..120 capsules tional Enzyme Company. Lipase...... 200 FIP in fiber or phenolic compounds. Amylase...... 12,000 DU Xylanase...... 12,500 XU Other Ingredients: Vegetable capsule (cellulose Glucoamylase...... 25 AGU Other Ingredients: Vegetable capsule (cellulose Protease SP 4.5...... 50,000 HUT and water). Contains cellulose and medium chain Serving Size: 1 Capsule Alpha-galactosidase...... 200 GalU and water). Contains cellulose and medium chain triglycerides as filler. For chewable tablet ingredi- Xylanase...... 16,000 XU triglycerides as filler. For chewable tablet ingredients, Other Ingredients: Vegetable capsule (cellulose Proprietary enzyme blend 288 .mg containing: ents, see website or bottle. and water) and maltodextrin. Beta-glucanase...... 30 BGU see container or website. No added filler. Xylanase...... 32,000 XU Lactase...... 1500 ALU HN004-S90...... 90 capsules, cellulose CereCalase®...... 1,500 MU HN002-S90...... 90 capsules HN006...... 120 capsules Lipase...... 500 FIP HN004-T120...... 180 chewable tablets HN002-T180...... 180 chewable tablets CereCalase® contains hemicellulase, glucanase, Other Ingredients: Vegetable capsule (cellulose and and phytase, and is a registered trademark of water), and microcystalline cellulose. For chewable National Enzyme Company. tablet and powder ingredients, see container or website. Other Ingredients: Vegetable capsule (cellulose and water), cellulose and medium HN005-90...... 90 capsules chain triglycerides as filler. For chewable tablet HN005-180...... 180 capsules ingredients, see website or bottle. HN005-T180...... 180 chewable tablets HN003-S90...... 90 capsules HN005-P180...... 180 dose powder HN003-T180...... 180 chewable tablets Enzyme Dosing What are Enzymes? Enzyme Quick Facts: Which Enzyme Product The amount of enzyme taken in a dose Enzymes are specialized proteins that is Right for You? is dependent upon the amount eaten, not accelerate biochemical reactions. The • Enzymes break down proteins, age or body weight. The more enzyme enzyme itself does not change during carbs and fats. Devin Houston, Ph.D. taken, the faster the food is broken down. the reaction, but changes one compound Experimentation with dosing is encouraged (known as the “substrate”) into another • Enzymes are safe in long-term use. Don’t know where to start? to find the optimal dose for your diet. (known as the “product”). If unsure as to which enzyme product is needed, use a • Enzymes are effective for children broad-spectrum formula such as Zyme Prime or TriEnza. Optimal dosing time is usually before or at Digestive enzymes include: as well as adults. Enzyme Products Formulated by the beginning of the meal, so that maximal • proteases/peptidases– Dr. Devin Houston, PhD Biochemist Adjusting to Zyme Prime is not difficult. Zyme Prime is mild contact time between enzymes and food break down proteins/peptides • Enzymes may be an alternative to and low in protease (protein digesting enzymes). Zyme Prime can occur. However, you may take the • carbohydrases– some special diets, such as GFCF should not cause discomfort and is an excellent starter product for the sensitive gut. enzymes at any point during the meal break down carbohydrates and SCD. or soon after and still obtain the • lipases– If desired results are not observed using Zyme Prime, either majority of benefits. break down triglyceride fats • Take enzymes near the beginning increase the dose, add another product (AFP-Peptizyde or of every meal. No-Fenol) or switch to TriEnza. To begin, give enzymes with only 1 meal Proteins are degraded to peptides and is a broad-spectrum product, containing enzymes per day for a few days. Increase gradually amino acids, carbohydrates to sugars, TriEnza • Available in capsules, chewable from until you are taking a full dose with every and triglycerides to fatty acids by breaking tablets and powder. AFP-Peptizyde for proteins, enzymes from Zyme Prime for meal. More can be taken for those foods specific chemical bonds within the compound. fats & carbohydrates, and ½ the xylanase from No-Fenol for that cause dietary problems such as bloating, • Houston Enzymes is the only certain fruits and vegetables. TriEnza is higher in proteases gas, heaviness, etc. Most dietary enzyme supplements are company with the formulation than Zyme Prime. TriEnza has DPP IV activity, unlike Zyme derived from plants such as papaya, expertise of a PhD enzyme biochemist. Prime and, like AFP-Peptizyde, may be an alternative to the What happens if I take an enzyme pineapple, and Aspergillus fungi. The Gluten-Free, Casein-Free (GFCF) diet. supplement and don’t eat? enzymes derived from Aspergillus have Recommended dosing for TriEnza is 1 or 2 capsules Nothing. An enzyme is specific for one been purified from the fungal matter using with meals. substance; if that substance is not from 8 to 12 different methods of purification. present, the enzyme does nothing and simply continues along the digestive tract, No fungal matter is present in our enzyme eventually being degraded by enzymes in products. If you have a known allergy to Order online at www.houston-enzymes.com or call toll-free at 866-757-8627 the GI tract. Aspergillus proteins, then caution should be used in taking any fungal-derived Dosing chart for starting slowly is at enzyme product, however, the allergenic Considering the Gluten-Free, Loose stools, low weight, picky product than Zyme Prime for those with http://www.houston-enzymes.com/dosing. For Frequently Asked Questions and occasional constipation. No-Fenol may be portions of Aspergillus are usually those Casein-Free Diet? eater, carb craver, gas & bloating? added to any other enzyme product to lessen parts of the fungi removed from the Articles on Getting Started, Mixing any stool-firming tendencies. Enzymes, and Giving at School Many of our customers use the Gluten-Free, For concerns like loose stools, low weight, enzymes during processing. picky eater, or carb craver, consider using Mixing Enzymes Casein-Free (GFCF) diet for their children with Red cheeks and/or ears after special needs. If the parent complains about Zyme Prime or ZyCarb. eating certain fruits? Enzymes gradually lose their activity level Plant enzymes are stable in acidic conditions, the difficulty of doing the diet, or the child is once mixed in liquid or food. You can keep and begin to break down food while it is still wanting more freedom to eat “like his friends”, Zyme Prime is excellent for firming stools and breaking down carbohydrates. ZyCarb is similar, This can be a phenolic intolerance that may in the stomach. or the parent wishes to improve gluten- and enzymes “good” longer by putting them in a but less firming. be helped by using No-Fenol. cold drink, up to about four hours. Enzymes casein-connected behaviors, then consider the may be kept in a frozen drink for use later. high-protease AFP-Peptizyde. One capsule Food-related intolerances? “Shiners” under the eyes may also be an Quality Standards contains very potent quantities of DPP IV indicator that phenolic foods are a problem. peptidase plus additional proteases. Foods may break down quickly when mixed Skin rashes and rough patches on elbows while Our enzyme products meet the quality not restricting dietary gluten may be indicators Fats or oils causing digestive with enzymes. Nut butters and cooled standards established by the U.S. AFP-Peptizyde was one of our original products of gluten intolerance. Better digestion of gluten discomfort? chocolates are better choices for preserving invented as an alternative for the GFCF diet. can be accomplished through the use of enzymes for later use. The oil in nut butters Food and Drug Administration’s ruling AFP-Peptizyde and TriEnza are high-protease, protease enzymes. for current good manufacturing Lypazyme is formulated to help break down and chocolate helps to keep the enzymes with high DPP IV activity. TriEnza is a newer triglyceride fats while still in the stomach. Faster AFP-Peptizyde (or TriEnza) is recommended. encapsulated. Enzymes mixed with foods practices (CGMPs). This means combination product, but requires 2 capsules fat breakdown prevents the delay in stomach may be frozen for about two weeks. Enzymes our enzymes are manufactured to equal the protease activity of one emptying usually associated with high-fat meals. AFP-Peptizyde capsule. Is Constipation a Problem? remain active up to about 125-130 degrees consistently as to identity, purity, Lypazyme is helpful when supplementing with If so, avoid using Zyme Prime alone, as it fish oils and other sources of beneficial fats. Fahrenheit, but higher temperatures will strength, and composition. Best to start these high-protease products with inactivate them. Enzymes can be added decreases the fecal mass and firms the stool. low and slow dosing. If the child is already on As with any supplement, results can vary to foods after cooking, just prior to serving. These statements have not been evaluated If this is an issue, try adding the No-Fenol the GFCF diet, the parent should not change the product as it reduces stool firmness. with the individual and there is always the Enzymes are not harmed at all by cold by the FDA. These products are not intended diet until fully adjusted to enzymes. to diagnose, cure, treat, or prevent any exception. But most can use the above as a temperatures, in fact; the colder enzymes No-Fenol breaks down fiber which may help disease. Peptizyde™ is a trademark of guide for starting enzymes. The great thing are kept, the longer they keep their activity. These products are not used for celiac disease. soften the stool. No-Fenol can be used alone Houston Nutraceuticals, Inc. about enzymes is that they are not harmful No enzyme product is available for celiac or in combination with other enzyme products at any level of dosing, so you can experiment to counter their stool-firming tendencies. disease, or for “cheating” on a celiac diet, to find the best combination for your in any form. particular needs. © Copyright 2015 ZyCarb, which contains the enzymes found Houston Nutraceuticals, Inc in Zyme Prime plus xylanase, may be a better REV. 2/2015