Supporting Information
High-Throughput Virtual Screening of Proteins using GRID Molecular Interaction Fields
Simone Sciabola, Robert V. Stanton, James E. Mills, Maria M. Flocco, Massimo Baroni, Gabriele Cruciani, Francesca Perruccio and Jonathan S. Mason
Contents Table S1 S2-S21 Figure S1 S22
* To whom correspondence should be addressed: Simone Sciabola, Pfizer Research Technology Center, Cambridge, 02139 MA, USA Phone: +1-617-551-3327; Fax: +1-617-551-3117; E-mail: [email protected]
S1 Table S1. Description of the 990 proteins used as decoy for the Protein Virtual Screening analysis.
PDB ID Protein family Molecule Res. (Å)
1n24 ISOMERASE (+)-BORNYL DIPHOSPHATE SYNTHASE 2.3
1g4h HYDROLASE 1,3,4,6-TETRACHLORO-1,4-CYCLOHEXADIENE HYDROLASE 1.8
1cel HYDROLASE(O-GLYCOSYL) 1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE I 1.8
1vyf TRANSPORT PROTEIN 14 KDA FATTY ACID BINDING PROTEIN 1.85
1o9f PROTEIN-BINDING 14-3-3-LIKE PROTEIN C 2.7
1t1s OXIDOREDUCTASE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE 2.4
1t1r OXIDOREDUCTASE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE 2.3
1q0q OXIDOREDUCTASE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE 1.9
1jcy LYASE 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE 1.9
1fww LYASE 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE 1.85
1uk7 HYDROLASE 2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE 1.7
1v11 OXIDOREDUCTASE 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT 1.95
1x7w OXIDOREDUCTASE 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT 1.73
1d0l TRANSFERASE 35KD SOLUBLE LYTIC TRANSGLYCOSYLASE 1.97
2bt4 LYASE 3-DEHYDROQUINATE DEHYDRATASE 1.7
2c4w LYASE 3-DEHYDROQUINATE DEHYDRATASE 1.55
1nr5 LYASE 3-DEHYDROQUINATE SYNTHASE 2.1
2gfx TRANSFERASE 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2 2.59
1okz TRANSFERASE 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1 2.51
1q36 TRANSFERASE 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE 1.6
2vf3 TRANSFERASE 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE 2.2
1rr8 ISOMERASE/DNA DNA 2.6
1rrj ISOMERASE/DNA DNA 2.3
1jwl TRANSCRIPTION/DNA DNA 4
1jft TRANSCRIPTION/DNA DNA 2.5
1t8e TRANSFERASE/ELECTRON TRANSPORT/DNA DNA 2.54
1ryr TRANSFERASE/DNA DNA 2.28
1skm TRANSFERASE/DNA DNA 2.2
1k27 TRANSFERASE 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE 1.95
1hxa LYASE 5-EPI-ARISTOLOCHENE SYNTHASE 2.32
1rqr TRANSFERASE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE 2.67
2c5b TRANSFERASE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE 2.4
2c2w TRANSFERASE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE 2
1q8a TRANSFERASE 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINE 1.7
1u22 TRANSFERASE 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE-- 2.65
2qtg HYDROLASE 5'-METHYLTHIOADENOSINE NUCLEOSIDASE 1.84
1jdt TRANSFERASE 5'-METHYLTHIOADENOSINE PHOSPHORYLASE 2
2c97 TRANSFERASE 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE 2
1pgq OXIDOREDUCTASE (CHOH(D)-NADP+(A)) 6-PHOSPHOGLUCONATE DEHYDROGENASE 3.17
1mlz TRANSFERASE 7,8-DIAMINO-PELARGONIC ACID AMINOTRANSFERASE 2.15
2g6w TRANSFERASE 8-AMINO-7-OXONONANOATE SYNTHASE 2.14
1gkd HYDROLASE 92 KDA TYPE IV COLLAGENASE 2.1
1t9c TRANSFERASE ACETOLACTATE SYNTHASE, MITOCHONDRIAL 2.34
1t9b TRANSFERASE ACETOLACTATE SYNTHASE, MITOCHONDRIAL 2.2
1gqs HYDROLASE ACETYLCHOLINESTERASE 3
2jey HYDROLASE ACETYLCHOLINESTERASE 2.7
S2 1j07 HYDROLASE ACETYLCHOLINESTERASE 2.35
1jjb HYDROLASE ACETYLCHOLINESTERASE 2.3
1n5r HYDROLASE ACETYLCHOLINESTERASE 2.25
2vu2 TRANSFERASE ACETYL-COA ACETYLTRANSFERASE 2.65
2vu1 TRANSFERASE ACETYL-COA ACETYLTRANSFERASE 1.51
1pg3 LIGASE ACETYL-COA SYNTHETASE 2.3
3b6c TRANSCRIPTION ACTII PROTEIN 2.3
1n5s OXIDOREDUCTASE ACTVA-ORF6 MONOOXYGENASE 1.7
2hu8 HYDROLASE ACYLAMINO-ACID-RELEASING ENZYME 2.4
2a8h HYDROLASE ADAM 17 2.3
2fv9 HYDROLASE ADAM 17 2.02
2ddf HYDROLASE ADAM 17 1.7
1r55 HYDROLASE ADAM 33 1.58
2jih HYDROLASE ADAMTS-1 2.1
2ada HYDROLASE ADENOSINE DEAMINASE 2.4
2i6a TRANSFERASE ADENOSINE KINASE 2.2
3dhy HYDROLASE ADENOSYLHOMOCYSTEINASE 2
1s07 TRANSFERASE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE 2.42
1u0h LYASE ADENYLATE CYCLASE, TYPE V 2.9
1tl7 LYASE ADENYLATE CYCLASE, TYPE V 2.8
1cjk LYASE/LYASE/SIGNALING PROTEIN ADENYLATE CYCLASE, TYPE V 3
1cib LIGASE ADENYLOSUCCINATE SYNTHETASE 2.3
1p9b LIGASE ADENYLOSUCCINATE SYNTHETASE 2
1ab8 LYASE ADENYLYL CYCLASE 2.2
1v8t HYDROLASE ADP-RIBOSE PYROPHOSPHATASE 2.6
1s9d PROTEIN TRANSPORT/EXCHANGE FACTOR ADP-RIBOSYLATION FACTOR 1 1.8
1niv LECTIN AGGLUTININ 3
1jlx LECTIN AGGLUTININ 2.2
1msa LECTIN (AGGLUTININ) AGGLUTININ 2.29
1ugy SUGAR BINDING PROTEIN AGGLUTININ ALPHA CHAIN 2.4
1m9n TRANSFERASE, HYDROLASE AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE 1.93
1xql ISOMERASE ALANINE RACEMASE 1.8
1ee2 OXIDOREDUCTASE ALCOHOL DEHYDROGENASE 1.54
1s2c OXIDOREDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 1.8
1ah0 OXIDOREDUCTASE ALDOSE REDUCTASE 2.3
1eko OXIDOREDUCTASE ALDOSE REDUCTASE 2.2
1t40 OXIDOREDUCTASE ALDOSE REDUCTASE 1.8
1az1 OXIDOREDUCTASE ALDOSE REDUCTASE 1.8
2nvd OXIDOREDUCTASE ALDOSE REDUCTASE 1.55
1x97 OXIDOREDUCTASE ALDOSE REDUCTASE 1.4
1kap ZINC METALLOPROTEASE ALKALINE PROTEASE 1.64
1kn1 ELECTRON TRANSPORT ALLOPHYCOCYANIN 2.2
2bxu HYDROLASE ALPHA THROMBIN 2.8
2bvs HYDROLASE ALPHA THROMBIN 1.4
1bhx SERINE PROTEASE ALPHA THROMBIN 2.3
1kyu ENDOCYTOSIS/EXOCYTOSIS ALPHA-ADAPTIN C 1.8
1otj OXIDOREDUCTASE ALPHA-KETOGLUTARATE-DEPENDENT TAURINE 1.9
1nkh TRANSFERASE ACTIVATOR/TRANSFERASE ALPHA-LACTALBUMIN 2
1qw8 HYDROLASE ALPHA-L-ARABINOFURANOSIDASE 1.8
3d50 HYDROLASE ALPHA-MANNOSIDASE 2 1.79
S3 3ddg HYDROLASE ALPHA-MANNOSIDASE 2 1.74
3d52 HYDROLASE ALPHA-MANNOSIDASE 2 1.6
2f1b HYDROLASE ALPHA-MANNOSIDASE II 1.45
2f1a HYDROLASE ALPHA-MANNOSIDASE II 1.45
2f18 HYDROLASE ALPHA-MANNOSIDASE II 1.3
2f7p HYDROLASE ALPHA-MANNOSIDASE II 1.28
1ktc HYDROLASE ALPHA-N-ACETYLGALACTOSAMINIDASE 2.4
1d3t BLOOD CLOTTING ALPHA-THROMBIN 3
1bmn COMPLEX (SERINE PROTEASE/INHIBITOR) ALPHA-THROMBIN 2.8
1bmm COMPLEX (SERINE PROTEASE/INHIBITOR) ALPHA-THROMBIN 2.6
1lhd COMPLEX (SERINE PROTEASE/INHIBITOR) ALPHA-THROMBIN 2.35
1hdt COMPLEX (SERINE PROTEINASE/INHIBITOR) ALPHA-THROMBIN 2.6
1doj HYDROLASE/HYDROLASE INHIBITOR ALPHA-THROMBIN 1.7
1afe COMPLEX (SERINE PROTEASE/INHIBITOR) ALPHA-THROMBIN (SMALL SUBUNIT) 2
1ae8 COMPLEX (SERINE PROTEASE/INHIBITOR) ALPHA-THROMBIN (SMALL SUBUNIT) 2
1hlt COMPLEX(SERINE PROTEINASE/INHIBITOR) ALPHA-THROMBIN (SMALL SUBUNIT) 3
1abj HYDROLASE(SERINE PROTEINASE) ALPHA-THROMBIN (SMALL SUBUNIT) 2.4
1iht HYDROLASE(SERINE PROTEINASE) ALPHA-THROMBIN (SMALL SUBUNIT) 2.1
1ihs HYDROLASE(SERINE PROTEINASE) ALPHA-THROMBIN (SMALL SUBUNIT) 2
1nrr SERINE PROTEINASE/RECEPTOR ALPHA-THROMBIN (SMALL SUBUNIT) 2.4
1oip TRANSPORT ALPHA-TOCOPHEROL TRANSFER PROTEIN 1.95
1f2p HYDROLASE AMINOPEPTIDASE 1.8
1o69 STRUCTURAL GENOMICS, UNKNOWN FUNCTION AMINOTRANSFERASE 1.84
1jgi TRANSFERASE AMYLOSUCRASE 2
1gs4 ANDROGEN RECEPTOR ANDROGEN RECEPTOR 1.95
1j37 HYDROLASE ANGIOTENSIN CONVERTING ENZYME 2.4
1r4l HYDROLASE ANGIOTENSIN I CONVERTING ENZYME 2 3
1um5 IMMUNE SYSTEM ANTIBODY 21H3 L CHAIN 1.6
1a4k IMMUNOGLOBULIN ANTIBODY FAB 2.4
2z92 IMMUNE SYSTEM ANTI-CIGUATOXIN ANTIBODY 10C9 FAB HEAVY CHAIN 2.3
1vpo IMMUNE SYSTEM ANTI-TESTOSTERONE (LIGHT CHAIN) 2.15
1lk6 BLOOD CLOTTING ANTITHROMBIN-III 2.8
2nva LYASE ARGININE DECARBOXYLASE, A207R PROTEIN 1.8
1ls6 TRANSFERASE ARYL SULFOTRANSFERASE 1.9
1w6f TRANSFERASE ARYLAMINE N-ACETYLTRANSFERASE 2.1
1bkg AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE 2.6
1asd AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE 2.2
1ajs AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE 1.6
1toj TRANSFERASE ASPARTATE AMINOTRANSFERASE 1.9
2aat TRANSFERASE(AMINOTRANSFERASE) ASPARTATE AMINOTRANSFERASE 2.8
1aib TRANSFERASE(AMINOTRANSFERASE) ASPARTATE AMINOTRANSFERASE 2.8
1ams TRANSFERASE(AMINOTRANSFERASE) ASPARTATE AMINOTRANSFERASE 2.7
1art TRANSFERASE(AMINOTRANSFERASE) ASPARTATE AMINOTRANSFERASE 1.8
1tu0 HYDROLASE/HYDROLASE REGULATOR ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN 2.55
1r0c TRANSFERASE ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN 2.37
1at1 TRANSFERASE (CARBAMOYL-P,ASPARTATE) ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN 2.8
1pqp OXIDOREDUCTASE ASPARTATE-SEMIALDEHYDE DEHYDROGENASE 2.06
1g51 LIGASE ASPARTYL-TRNA SYNTHETASE 2.4
1v47 TRANSFERASE ATP SULFURYLASE 2.49
1lel UNKNOWN FUNCTION AVIDIN 2.9
S4 2fhl SUGAR BINDING PROTEIN AVIDIN-RELATED PROTEIN 4/5 1.05
1a6v IMMUNOGLOBULIN B1-8 FV (LIGHT CHAIN) 1.8
2iq6 HYDROLASE BACTERIAL LEUCYL AMINOPEPTIDASE 2
2vsl LIGASE BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4 2.1
1xb1 APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8 2.7
1xb0 APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8 2.2
1q6z LYASE BENZOYLFORMATE DECARBOXYLASE 1
1fgx TRANSFERASE BETA 1,4 GALACTOSYLTRANSFERASE 2.4
2vt4 RECEPTOR BETA1 ADRENERGIC RECEPTOR 2.7
3d4s MEMBRANE PROTEIN BETA-2 ADRENERGIC RECEPTOR/T4-LYSOZYME CHIMERA 2.8
1fiw HYDROLASE BETA-ACROSIN HEAVY CHAIN 2.1
1r43 HYDROLASE BETA-ALANINE SYNTHASE 2.8
1lq2 HYDROLASE BETA-D-GLUCAN GLUCOHYDROLASE ISOENZYME EXO1 2.7
1jyv HYDROLASE BETA-GALACTOSIDASE 1.75
1jyw HYDROLASE BETA-GALACTOSIDASE 1.55
1e1f GLYCOSIDE HYDROLASE BETA-GLUCOSIDASE 2.6
1e4n GLYCOSIDE HYDROLASE BETA-GLUCOSIDASE 2.1
2cer HYDROLASE BETA-GLUCOSIDASE A 2.29
1np0 HYDROLASE BETA-HEXOSAMINIDASE BETA CHAIN 2.5
1iem HYDROLASE BETA-LACTAMASE 2.3
1kds HYDROLASE BETA-LACTAMASE 2.15
1kvm HYDROLASE BETA-LACTAMASE 2.06
2pu2 HYDROLASE BETA-LACTAMASE 1.86
1ymx HYDROLASE BETA-LACTAMASE CTX-M-9 1.7
1hlk HYDROLASE BETA-LACTAMASE, TYPE II 2.5
1gx8 LIPOCALIN BETA-LACTOGLOBULIN 2.4
2vo5 HYDROLASE BETA-MANNOSIDASE 2.3
1m01 HYDROLASE BETA-N-ACETYLHEXOSAMINIDASE 2.1
1o03 ISOMERASE BETA-PHOSPHOGLUCOMUTASE 1.4
1o3e HYDROLASE BETA-TRYPSIN 1.64
1o2k HYDROLASE BETA-TRYPSIN 1.63
1o3o HYDROLASE BETA-TRYPSIN 1.55
1o34 HYDROLASE BETA-TRYPSIN 1.5
1o2v HYDROLASE BETA-TRYPSIN 1.5
1o2u HYDROLASE BETA-TRYPSIN 1.41
1gi4 HYDROLASE BETA-TRYPSIN 1.37
1max HYDROLASE (SERINE PROTEASE) BETA-TRYPSIN 1.8
1j3k OXIDOREDUCTASE, TRANSFERASE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE 2.1
1sej TRANSFERASE, OXIDOREDUCTASE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE 2.87
1p4r TRANSFERASE, HYDROLASE BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH 2.55
1tiw OXIDOREDUCTASE BIFUNCTIONAL PUTA PROTEIN 2
1fl3 IMMUNE SYSTEM BLUE FLUORESCENT ANTIBODY (19G2)-HEAVY CHAIN 2.45
1ism HYDROLASE BONE MARROW STROMAL CELL ANTIGEN 1 3
1d1x OXIDOREDUCTASE BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME 2
1dtw OXIDOREDUCTASE BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE 2.7
2vz6 TRANSFERASE CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE 2.3
1nx0 HYDROLASE CALCIUM-DEPENDENT PROTEASE, SMALL SUBUNIT 2.3
1qiw CALCIUM-BINDING PROTEIN CALMODULIN 2.3
1ne4 HYDROLASE CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA 2.4
1rek TRANSFERASE CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC 2.3
S5 1xn0 HYDROLASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B 2.31
1xos HYDROLASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B 2.28
1tb5 HYDROLASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B 2.15
1ror HYDROLASE CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B 2
1bnm LYASE CARBONIC ANHYDRASE 2.6
1bnv LYASE CARBONIC ANHYDRASE 2.4
1bnq LYASE CARBONIC ANHYDRASE 2.4
1bn3 LYASE CARBONIC ANHYDRASE 2.2
2hoc LYASE CARBONIC ANHYDRASE 2 2.1
2gd8 LYASE CARBONIC ANHYDRASE 2 1.46
1bzm LYASE(OXO-ACID) CARBONIC ANHYDRASE I 2
1yda HYDRO-LYASE CARBONIC ANHYDRASE II 2.1
1okn LYASE CARBONIC ANHYDRASE II 2.4
1if9 LYASE CARBONIC ANHYDRASE II 2
1i91 LYASE CARBONIC ANHYDRASE II 2
1avn LYASE CARBONIC ANHYDRASE II 2
1i9m LYASE CARBONIC ANHYDRASE II 1.84
1zgf LYASE CARBONIC ANHYDRASE II 1.75
1zfk LYASE CARBONIC ANHYDRASE II 1.56
2fos LYASE CARBONIC ANHYDRASE II 1.1
1cny LYASE (OXO-ACID) CARBONIC ANHYDRASE II 2.3
1cin LYASE(OXO-ACID) CARBONIC ANHYDRASE II 2.1
1cil LYASE(OXO-ACID) CARBONIC ANHYDRASE II 1.6
3znc LYASE CARBONIC ANHYDRASE IV 2.8
1cps HYDROLASE(C-TERMINAL PEPTIDASE) CARBOXYPEPTIDASE A 2.25
8cpa HYDROLASE(C-TERMINAL PEPTIDASE) CARBOXYPEPTIDASE A 2
1cbx HYDROLASE(C-TERMINAL PEPTIDASE) CARBOXYPEPTIDASE A 2
2v77 HYDROLASE CARBOXYPEPTIDASE A1 1.6
1dtd HYDROLASE/HYDROLASE INHIBITOR CARBOXYPEPTIDASE A2 1.65
2pj2 HYDROLASE CARBOXYPEPTIDASE B 1.95
2pj7 HYDROLASE CARBOXYPEPTIDASE B 1.77
2pj8 HYDROLASE CARBOXYPEPTIDASE B 1.7
2pj1 HYDROLASE CARBOXYPEPTIDASE B 1.64
2pj6 HYDROLASE CARBOXYPEPTIDASE B 1.6
2pj9 HYDROLASE CARBOXYPEPTIDASE B 1.56
1tw2 TRANSFERASE CARMINOMYCIN 4-O-METHYLTRANSFERASE 2.5
2pvn TRANSFERASE CASEIN KINASE II SUBUNIT ALPHA 2
2pvm TRANSFERASE CASEIN KINASE II SUBUNIT ALPHA 2
3h30 TRANSFERASE CASEIN KINASE II SUBUNIT ALPHA 1.56
1j91 TRANSFERASE CASEIN KINASE II, ALPHA CHAIN 2.22
1m2q TRANSFERASE CASEIN KINASE II, ALPHA CHAIN 1.79
1rhm HYDROLASE CASP-3 2.5
1nmq APOPTOSIS, HYDROLASE CASPASE-3 2.4
1re1 HYDROLASE CASPASE-3 2.5
3dei HYDROLASE, APOPTOSIS CASPASE-3 2.8
3dej HYDROLASE, APOPTOSIS CASPASE-3 2.6
3dek HYDROLASE, APOPTOSIS CASPASE-3 2.4
1hw5 GENE REGULATION CATABOLITE GENE ACTIVATOR 1.82
1dlt OXIDOREDUCTASE CATECHOL 1,2-DIOXYGENASE 1.9
1ito HYDROLASE CATHEPSIN B 2.29
S6 1the HYDROLASE CATHEPSIN B 1.9
1au0 HYDROLASE CATHEPSIN K 2.6
1q6k HYDROLASE CATHEPSIN K 2.1
1npz HYDROLASE CATHEPSIN S 2
1ms6 HYDROLASE CATHEPSIN S 1.9
2ft2 TRANSFERASE CATHEPSIN S 1.7
1p5e CELL CYCLE CELL DIVISION PROTEIN KINASE 2 2.22
1h27 CELL CYCLE CELL DIVISION PROTEIN KINASE 2 2.2
1urc KINASE CELL DIVISION PROTEIN KINASE 2 2.6
2uzd TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.72
2bkz TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.6
2bhh TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.6
2j9m TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.5
1pxl TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.5
3bhu TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.3
2uzo TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.3
2c6l TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.3
2vtj TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.2
2duv TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.2
1gij TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.2
3bhv TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.1
2w06 TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2.04
2ds1 TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2
1h1s TRANSFERASE CELL DIVISION PROTEIN KINASE 2 2
1jsv TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.96
2w05 TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.9
2vv9 TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.9
2vts TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.9
2b52 TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.88
2fvd TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.85
1urw TRANSFERASE CELL DIVISION PROTEIN KINASE 2 1.6
1y2g CELL CYCLE CELL DIVISION PROTEIN ZIPA 1.9
1opb RETINOL TRANSPORT CELLULAR RETINOL BINDING PROTEIN II 1.9
1fsw HYDROLASE CEPHALOSPORINASE 1.9
1udu HYDROLASE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 2.83
1d6f TRANSFERASE CHALCONE SYNTHASE 1.69
1c5c IMMUNE SYSTEM CHIMERIC DECARBOXYLASE ANTIBODY 21D8 1.61
3chd HYDROLASE CHITINASE 2
1h0g HYDROLASE CHITINASE B 2
1w1t HYDROLASE CHITINASE B 1.9
1o6i HYDROLASE CHITINASE B 1.7
1waw HYDROLASE CHITOTRIOSIDASE 1 1.75
1qhy TRANSFERASE CHLORAMPHENICOL PHOSPHOTRANSFERASE 2.6
1hm3 LYASE CHONDROITINASE AC 2.1
2q21 ONCOGENE PROTEIN C-H-RAS P21 PROTEIN CATALYTIC DOMAIN 2.2
1csr OXO-ACID-LYASE CITRATE SYNTHASE 1.7
3bff HYDROLASE CLASS A BETA-LACTAMASE SED1 1.9
1wqv HYDROLASE COAGULATION FACTOR VII 2.5
1wss HYDROLASE/BLOOD CLOTTING COAGULATION FACTOR VII 2.6
2j94 HYDROLASE COAGULATION FACTOR X 2.1
S7 2j2u HYDROLASE COAGULATION FACTOR X HEAVY CHAIN 1.9
1iqj HYDROLASE COAGULATION FACTOR XA 3
1iqi HYDROLASE COAGULATION FACTOR XA 2.9
1ksn HYDROLASE COAGULATION FACTOR XA 2.1
1f0s HYDROLASE COAGULATION FACTOR XA 2.1
1f0r HYDROLASE COAGULATION FACTOR XA 2.1
1vam LECTIN CONCANAVALIN A 2.75
1swn BIOTIN-BINDING PROTEIN CORE-STREPTAVIDIN 2.2
3d4n OXIDOREDUCTASE CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 2.5
2vdy TRANSPORT PROTEIN CORTICOSTEROID-BINDING GLOBULIN 2.3
2aim HYDROLASE CRUZAIN 2.2
1ewl HYDROLASE CRUZAIN 2
1i29 LYASE CSDB 2.8
1a1b COMPLEX (TRANSFERASE/PEPTIDE) C-SRC TYROSINE KINASE 2.2
1dm2 CELL CYCLE CYCLIN-DEPENDENT KINASE 2 2.1
1e1x PROTEIN KINASE CYCLIN-DEPENDENT PROTEIN KINASE 2 1.85
1aws COMPLEX (ISOMERASE/PEPTIDE) CYCLOPHILIN A 2.55
1vbs COMPLEX (ISOMERASE/PEPTIDE) CYCLOPHILIN A 2
1lop COMPLEX (ISOMERASE/PEPTIDE) CYCLOPHILIN A 1.8
1vdn ISOMERASE CYCLOPHILIN A 1.6
1vai ISOMERASE CYCLOPHILIN B 1.8
1v9t ISOMERASE CYCLOPHILIN B 1.7
1kpg TRANSFERASE CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 1 2
1cl2 METHIONINE BIOSYNTHESIS CYSTATHIONINE BETA-LYASE 2.2
1ux0 HYDROLASE CYTIDINE DEAMINASE 1.99
1szf OXIDOREDUCTASE CYTOCHROME B2, MITOCHONDRIAL 2.7
1aee OXIDOREDUCTASE CYTOCHROME C PEROXIDASE 2.1
1ds4 OXIDOREDUCTASE CYTOCHROME C PEROXIDASE 2.02
1bem PEROXIDASE CYTOCHROME C PEROXIDASE 2.2
1r9o OXIDOREDUCTASE CYTOCHROME P450 2C9 2
1w0f OXIDOREDUCTASE CYTOCHROME P450 3A4 2.65
1lwl OXIDOREDUCTASE CYTOCHROME P450-CAM 2.2
1dz9 OXIDOREDUCTASE CYTOCHROME P450-CAM 1.9
1k70 HYDROLASE CYTOSINE DEAMINASE 1.8
2zox HYDROLASE CYTOSOLIC BETA-GLUCOSIDASE 1.9
1psd OXIDOREDUCTASE (NAD(A)) D-3-PHOSPHOGLYCERATE DEHYDROGENASE 2.75
1an9 OXIDOREDUCTASE D-AMINO ACID OXIDASE 2.5
2zi9 TRANSFERASE DEOXYCYTIDINE KINASE 2.51
1p62 TRANSFERASE DEOXYCYTIDINE KINASE 1.9
1xs4 HYDROLASE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE 2.53
1sm8 HYDROLASE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE 2.9
1twz TRANSFERASE DHPS, DIHYDROPTEROATE SYNTHASE 2.75
2c29 OXIDOREDUCTASE DIHYDROFLAVONOL 4-REDUCTASE 1.81
1pd9 OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE 2.2
1hfr OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE 2.1
1m79 OXIDOREDUCTASE DIHYDROFOLATE REDUCTASE 1.7
1ddr OXIDO-REDUCTASE DIHYDROFOLATE REDUCTASE 2.45
1rri LYASE DIHYDRONEOPTERIN ALDOLASE 2
1j79 HYDROLASE DIHYDROOROTASE 1.7
1jqv OXIDOREDUCTASE DIHYDROOROTATE DEHYDROGENASE A 2.1
S8 1aj0 SYNTHASE DIHYDROPTEROATE SYNTHASE 2
3c43 HYDROLASE DIPEPTIDYL PEPTIDASE 4 2.3
3eio HYDROLASE DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM 2
1hap HYDROLASE/HYDROLASE INHIBITOR/DNA DNA (5'- 2.8
1hao HYDROLASE/HYDROLASE INHIBITOR/DNA DNA (5'- 2.8
1efa TRANSCRIPTION/DNA DNA (5'- 2.6
1trr TRANSCRIPTION/DNA DNA (5'- 2.4
1t7p TRANSFERASE/DNA DNA (5'-D(P*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*2DA)- 2.2
1j53 TRANSFERASE DNA POLYMERASE III, EPSILON CHAIN 1.8
1cr4 TRANSFERASE DNA PRIMASE/HELICASE 2.5
1cy1 ISOMERASE DNA TOPOISOMERASE I 2.3
1usq ADHESIN DR HEMAGGLUTININ STRUCTURAL SUBUNIT 1.9
2jkj CELL ADHESION DR HEMAGGLUTININ STRUCTURAL SUBUNIT 2.3
2jkn CELL ADHESION DR HEMAGGLUTININ STRUCTURAL SUBUNIT 1.9
1xlj ISOMERASE(INTRAMOLECULAR OXIDOREDUCTSE) D-XYLOSE ISOMERASE 2.5
2r40 GENE REGULATION ECDYSONE RECEPTOR 2.4
2g19 OXIDOREDUCTASE EGL NINE HOMOLOG 1 1.7
2hbt OXIDOREDUCTASE EGL NINE HOMOLOG 1 1.6
1fmb HYDROLASE (ACID PROTEINASE) EIAV PROTEASE 1.8
1bma COMPLEX (SERINE PROTEASE/INHIBITOR) ELASTASE 1.8
1f9o HYDROLASE/HYDROLASE INHIBITOR ENDO-1,4-BETA-GLUCANASE F 2.5
1gor HYDROLASE ENDO-1,4-BETA-XYLANASE 1.7
1uu6 HYDROLASE ENDO-BETA-1,4-GLUCANASE 1.4
2oym HYDROLASE ENDOGLYCOCERAMIDASE II 1.86
1u2o CHAPERONE ENDOPLASMIN 2.1
1l8j BLOOD CLOTTING ENDOTHELIAL PROTEIN C RECEPTOR 2
1uqz HYDROLASE ENDOXYLANASE 1.55
2one LYASE ENOLASE 2
1lxc OXIDOREDUCTASE ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] 2.4
1mfp OXIDOREDUCTASE ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] 2.33
1hi4 HYDROLASE EOSINOPHIL-DERIVED NEUROTOXIN 1.8
1xkk TRANSFERASE EPIDERMAL GROWTH FACTOR RECEPTOR 2.4
1etr HYDROLASE(SERINE PROTEINASE) EPSILON-THROMBIN 2.2
1g6s TRANSFERASE EPSP SYNTHASE 1.5
1qyw OXIDOREDUCTASE ESTRADIOL 17 BETA-DEHYDROGENASE 1 1.63
1a52 RECEPTOR ESTROGEN RECEPTOR 2.8
1x7e TRANSCRIPTION ESTROGEN RECEPTOR 1 (ALPHA) 2.8
1qkn NUCLEAR RECEPTOR ESTROGEN RECEPTOR BETA 2.25
1l2j TRANSCRIPTION RECEPTOR ESTROGEN RECEPTOR BETA 2.95
1aqu TRANSFERASE ESTROGEN SULFOTRANSFERASE 1.6
1dht OXIDOREDUCTASE ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE 2.24
1s9q TRANSCRIPTION ESTROGEN-RELATED RECEPTOR GAMMA 2.2
1ej4 TRANSLATION EUKARYOTIC INITIATION FACTOR 4E 2.25
2v3r HYDROLASE EXOGLUCANASE 1 1.6
2v3i HYDROLASE EXOGLUCANASE 1 1.05
1dma ADP-RIBOSYLATION EXOTOXIN A 2.5
1aer ADP-RIBOSYLATION EXOTOXIN A 2.3
1mzf OXIDOREDUCTASE FACTOR INHIBITING HIF1 2.4
1ubw TRANSFERASE FARNESYL DIPHOSPHATE SYNTHASE 2.5
2i19 TRANSFERASE FARNESYL PYROPHOSPHATE SYNTHASE 2.28
S9 2ogd TRANSFERASE FARNESYL PYROPHOSPHATE SYNTHASE 2
3cp6 TRANSFERASE FARNESYL PYROPHOSPHATE SYNTHETASE 1.95
3b7l TRANSFERASE FARNESYL PYROPHOSPHATE SYNTHETASE 1.95
2opm TRANSFERASE FARNESYL PYROPHOSPHATE SYNTHETASE (FPP 2.4
1fe3 LIPID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, BRAIN 2.8
2tcl HYDROLASE (METALLOPROTEASE) FIBROBLAST COLLAGENASE 2.2
1fkh CIS-TRANS ISOMERASE FK506 BINDING PROTEIN 1.95
1qjd FUMARATE REDUCTASE FLAVOCYTOCHROME C3 1.8
1e39 FUMARATE REDUCTASE FLAVOCYTOCHROME C3 1.8
1c7f ELECTRON TRANSPORT FLAVODOXIN 2
1akq ELECTRON TRANSPORT FLAVODOXIN 1.9
1wsb ELECTRON TRANSPORT FLAVODOXIN 1.8
1czn ELECTRON TRANSPORT FLAVODOXIN 1.7
1jbw LIGASE FOLYLPOLYGLUTAMATE SYNTHASE 1.85
2fhk TRANSFERASE FORMYLMETHANOFURAN--TETRAHYDROMETHANOPTERIN 2
1rdz HYDROLASE FRUCTOSE 1,6-BISPHOSPHATASE 2.05
1fpf HYDROLASE (PHOSPHORIC MONOESTER) FRUCTOSE 1,6-BISPHOSPHATASE 2.1
1fbf HYDROLASE(PHOSPHORIC MONOESTER) FRUCTOSE 1,6-BISPHOSPHATASE 2.7
1frp HYDROLASE(PHOSPHORIC MONOESTER) FRUCTOSE 1,6-BISPHOSPHATASE 2
1eyj HYDROLASE FRUCTOSE-1,6-BISPHOSPHATASE 2.28
2vt5 HYDROLASE FRUCTOSE-1,6-BISPHOSPHATASE 1 2.2
1y0y HYDROLASE FRV OPERON PROTEIN FRVX 1.6
1ofz SUGAR-BINDING PROTEIN FUCOSE-SPECIFIC LECTIN 1.5
1fup LYASE FUMARASE C 2.3
1ga8 TRANSFERASE GALACTOSYL TRANSFERASE LGTC 2
1tjj SIGNALING PROTEIN GANGLIOSIDE GM2 ACTIVATOR 2
2e92 TRANSFERASE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE 2.31
2z7h TRANSFERASE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE 2.08
2z50 TRANSFERASE GERANYLGERANYL PYROPHOSPHATE SYNTHETASE 2.01
3ed1 HYDROLASE RECEPTOR GIBBERELLIN RECEPTOR GID1 1.9
1cvr HYDROLASE GINGIPAIN R 2
1ec8 LYASE GLUCARATE DEHYDRATASE 1.9
1v4s TRANSFERASE GLUCOKINASE ISOFORM 2 2.3
1ko8 TRANSFERASE GLUCONATE KINASE 2.4
1hor INTRAMOLECULAR OXIDOREDUCTASE DEAMINASE GLUCOSAMINE 6-PHOSPHATE DEAMINASE 2.4
1mos TRANSFERASE GLUCOSAMINE 6-PHOSPHATE SYNTHASE 2
1e7y OXIDOREDUCTASE GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE 2.48
1nt4 HYDROLASE GLUCOSE-1-PHOSPHATASE 2.4
1tzc ISOMERASE GLUCOSE-6-PHOSPHATE ISOMERASE, CONJECTURAL 1.45
1gle PHOSPHOTRANSFERASE GLUCOSE-SPECIFIC PROTEIN IIIGLC 2.94
2v3e HYDROLASE GLUCOSYLCERAMIDASE 2
3bhx HYDROLASE GLUTAMATE CARBOXYPEPTIDASE 2 1.6
2c6c HYDROLASE GLUTAMATE CARBOXYPEPTIDASE II 2
1i9c ISOMERASE GLUTAMATE MUTASE 1.9
1lb9 MEMBRANE PROTEIN GLUTAMATE RECEPTOR 2 2.3
1m5f MEMBRANE PROTEIN GLUTAMATE RECEPTOR 2 1.95
1syh MEMBRANE PROTEIN GLUTAMATE RECEPTOR 2 1.8
1mqj MEMBRANE PROTEIN GLUTAMATE RECEPTOR 2 1.65
2qs3 MEMBRANE PROTEIN GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1 1.76
1v2e TRANSFERASE GLUTAMINE AMINOTRANSFERASE 2.6
S10 1gra OXIDOREDUCTASE GLUTATHIONE REDUCTASE 2
12gs COMPLEX (TRANSFERASE/NONYL-GLUTATHIONE) GLUTATHIONE S-TRANSFERASE 2.1
1gsq TRANSFERASE GLUTATHIONE S-TRANSFERASE 2.4
1a0f TRANSFERASE GLUTATHIONE S-TRANSFERASE 2.1
1oyj TRANSFERASE GLUTATHIONE S-TRANSFERASE 1.95
1pn9 TRANSFERASE GLUTATHIONE S-TRANSFERASE 1-6 2
1gsa LIGASE GLUTATHIONE SYNTHETASE 2
1m66 OXIDOREDUCTASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1.9
1c3e TRANSFERASE GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE 2.1
1nbi TRANSFERASE GLYCINE N-METHYLTRANSFERASE 3
2prj TRANSFERASE GLYCOGEN PHOSPHORYLASE 2.3
1k08 TRANSFERASE GLYCOGEN PHOSPHORYLASE 2.26
2qln TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 2.15
3bcr TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 2.14
2qlm TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 2.1
1xl1 TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 2.1
2qn3 TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.96
1z62 TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.9
2qrp TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.86
2qrg TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.85
2qrh TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.83
2qrq TRANSFERASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM 1.8
1uv5 TRANSFERASE GLYCOGEN SYNTHASE KINASE-3 BETA 2.8
2evs LIPID TRANSPORT GLYCOLIPID TRANSFER PROTEIN 2.2
1r7t TRANSFERASE GLYCOPROTEIN-FUCOSYLGALACTOSIDE ALPHA-N- 2.09
1xcj TRANSFERASE GUANIDINOACETATE N-METHYLTRANSFERASE 2
1i3f HYDROLASE GUANYL-SPECIFIC RIBONUCLEASE T1 2.35
1n1l VIRAL PROTEIN HCV NS3 SERINE PROTEASE 2.6
1lti ENTEROTOXIN HEAT LABILE ENTEROTOXIN TYPE I 2.13
1yet CHAPERONE PROTEIN HEAT SHOCK PROTEIN 90 1.9
1uyc CHAPERONE HEAT SHOCK PROTEIN HSP 90-ALPHA 2
2qg0 CHAPERONE HEAT SHOCK PROTEIN HSP 90-ALPHA 1.85
2qg2 CHAPERONE HEAT SHOCK PROTEIN HSP 90-ALPHA 1.8
2cct CHAPERONE HEAT SHOCK PROTEIN HSP-90 ALPHA 2.3
2ccs CHAPERONE HEAT SHOCK PROTEIN HSP-90 ALPHA 1.79
2byi CHAPERONE HEAT SHOCK PROTEIN HSP90-ALPHA 1.6
1fd7 TOXIN HEAT-LABILE ENTEROTOXIN B CHAIN 1.8
1bdg HEXOKINASE HEXOKINASE 2.6
2yhx TRANSFERASE(PHOSPHORYL,ALCOHOL ACCEPTR) HEXOKINASE B 2.1
1gey TRANSFERASE HISTIDINOL-PHOSPHATE AMINOTRANSFERASE 2.3
1zjo TRANSFERASE HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE (NAGAT) 1.64
3f2k TRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR 1.85
1a9m ASPARTYL PROTEASE HIV-1 PROTEASE 2.3
1axa ASPARTYL PROTEASE HIV-1 PROTEASE 2
1mes ASPARTYL PROTEASE HIV-1 PROTEASE 1.9
1odx COMPLEX (ASPARTYL PROTEASE/PEPTIDE) HIV-1 PROTEASE 2
1d4h HYDROLASE HIV-1 PROTEASE 1.81
1gno HYDROLASE (ACID PROTEASE) HIV-1 PROTEASE 2.3
1hte HYDROLASE(ACID PROTEINASE) HIV-1 PROTEASE 2.8
1hps HYDROLASE(ACID PROTEINASE) HIV-1 PROTEASE 2.3
S11 1htf HYDROLASE(ACID PROTEINASE) HIV-1 PROTEASE 2.2
1heg HYDROLASE(ACID PROTEINASE) HIV-1 PROTEASE 2.2
1rti NUCLEOTIDYLTRANSFERASE HIV-1 REVERSE TRANSCRIPTASE 3
1klm NUCLEOTIDYLTRANSFERASE HIV-1 REVERSE TRANSCRIPTASE 2.65
1lw2 TRANSFERASE HIV-1 REVERSE TRANSCRIPTASE 3
1jld COMPLEX (PROTEASE/INHIBITOR) HIV-2 PROTEASE 2.5
1ebu OXIDOREDUCTASE HOMOSERINE DEHYDROGENASE 2.6
1nav MEMBRANE PROTEIN HORMONE RECEPTOR ALPHA 1, THRA1 2.5
2gby TRANSCRIPTION HTH-TYPE TRANSCRIPTIONAL REGULATOR QACR 2.9
1deh OXIDOREDUCTASE HUMAN BETA1 ALCOHOL DEHYDROGENASE 2.2
1ppg HYDROLASE(SERINE PROTEINASE) HUMAN LEUKOCYTE ELASTASE 2.3
2rs3 VIRUS HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1) 3
1hrv VIRUS HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1) 3
1i8q LYASE HYALURONATE LYASE 2.2
1ojm LYASE HYALURONATE LYASE 1.78
2j62 HYDROLASE HYALURONIDASE 2.26
1ah5 LYASE HYDROXYMETHYLBILANE SYNTHASE 2.4
1ypn LYASE HYDROXYMETHYLBILANE SYNTHASE 2.3
1dwq HYDROXYNITRILE LYASE HYDROXYNITRILE LYASE 2.2
1ty8 STRUCTURAL GENOMICS, UNKNOWN FUNCTION HYPOTHETICAL 32.1 KDA PROTEIN IN ADH3-RCA1 2.1
1iit MEMBRANE PROTEIN HYPOTHETICAL PROTEIN SLR1257 1.9
1i0i TRANSFERASE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE 2.06
1lo2 IMMUNE SYSTEM IF KAPPA LIGHT CHAIN 2
1wz1 IMMUNE SYSTEM IG LIGHT CHAIN 1.85
1ind IMMUNOGLOBULIN IGG1-LAMBDA CHA255 FAB (LIGHT CHAIN) 2.2
1yec CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3) 1.9
1kno CATALYTIC ANTIBODY IGG2A FAB FRAGMENT CNJ206 3.2
1igj IMMUNOGLOBULIN IGG2A-KAPPA 26-10 FAB (LIGHT CHAIN) 2.5
1mrf IMMUNOGLOBULIN IGG2B-KAPPA JEL103 FAB (LIGHT CHAIN) 2.4
1oau IMMUNE SYSTEM IMMUNOGLOBULIN E 1.8
1ynk IMMUNE SYSTEM IMMUNOGLOBULIN KAPPA LIGHT CHAIN 2.1
1mcn IMMUNE SYSTEM IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) 2.7
1mci IMMUNE SYSTEM IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) 2.7
1mcj IMMUNOGLOBULIN IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) 2.7
1mcb IMMUNOGLOBULIN IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) 2.7
1mj7 IMMUNE SYSTEM IMMUNOGLOBULIN MS5-393 2.25
1mh5 IMMUNE SYSTEM IMMUNOGLOBULIN MS6-164 2.1
1dd6 HYDROLASE IMP-1 METALLO BETA-LACTAMASE 2
1gcj TRANSPORT PROTEIN IMPORTIN BETA 2.6
1lbf LYASE INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE 2.05
1a53 SYNTHASE INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE 2
1n2n OXIDOREDUCTASE INDUCIBLE NITRIC OXIDE SYNTHASE 2.4
1ing HYDROLASE (O-GLYCOSYL) INFLUENZA A SUBTYPE N2 NEURAMINIDASE 2.4
1iny HYDROLASE INFLUENZA A SUBTYPE N9 NEURAMINIDASE 2.4
1ivb HYDROLASE (O-GLYCOSYL) INFLUENZA VIRUS B/LEE/40 NEURAMINIDASE 2.4
1jcn OXIDOREDUCTASE INOSINE MONOPHOSPHATE DEHYDROGENASE I 2.5
1me7 OXIDOREDUCTASE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2.15
1meh OXIDOREDUCTASE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1.95
1imb HYDROLASE INOSITOL MONOPHOSPHATASE 2.2
2vdm CELL ADHESION/IMMUNE SYSTEM INTEGRIN ALPHA-IIB 2.9
S12 1xdd IMMUNE SYSTEM INTEGRIN ALPHA-L 2.2
1tq4 SIGNALING PROTEIN INTERFERON-INDUCIBLE GTPASE 1.95
1m4a CYTOKINE INTERLEUKIN-2 2.18
1m48 CYTOKINE INTERLEUKIN-2 1.95
1cwv STRUCTURAL PROTEIN INVASIN 2.3
1bl5 OXIDOREDUCTASE ISOCITRATE DEHYDROGENASE 2.5
1grp OXIDOREDUCTASE (NAD(A)-CHOH(D)) ISOCITRATE DEHYDROGENASE 2.5
1n47 SUGAR BINDING PROTEIN ISOLECTIN B4 2.7
1e3r ISOMERASE ISOMERASE 2.5
1bk0 B-LACTAM ANTIBIOTIC ISOPENICILLIN N SYNTHASE 1.3
1oc1 OXIDOREDUCTASE ISOPENICILLIN N SYNTHETASE 2.2
2ze6 TRANSFERASE ISOPENTENYL TRANSFERASE 2.1
1x83 ISOMERASE ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 1.8
1lro LYASE KDO-8-PHOSPHATE SYNTHETASE 1.8
2paf TRANSCRIPTION LACTOSE OPERON REPRESSOR 3.5
2pe5 TRANSCRIPTION/DNA LACTOSE OPERON REPRESSOR 3.5
1qpe TRANSFERASE LCK KINASE 2
2jdz CARBOHYDRATE-BINDING PROTEIN LECTIN ALPHA CHAIN 2.1
2je7 SUGAR-BINDING PROTEIN LECTIN ALPHA CHAIN 1.65
1loc LECTIN LEGUME ISOLECTIN I (ALPHA CHAIN) 2.05
1pwq HYDROLASE LETHAL FACTOR 3.52
1gp5 DIOXYGENASE LEUCOANTHOCYANIDIN DIOXYGENASE 2.2
1gp6 OXYGENASE LEUCOANTHOCYANIDIN DIOXYGENASE 1.75
1gw6 HYDROLASE LEUKOTRIENE A-4 HYDROLASE 2.2
3chq HYDROLASE LEUKOTRIENE A-4 HYDROLASE 2.09
3b7u HYDROLASE LEUKOTRIENE A-4 HYDROLASE 1.9
3b7r HYDROLASE LEUKOTRIENE A-4 HYDROLASE 1.81
1n8q OXIDOREDUCTASE LIPOXYGENASE-3 2.1
1jnq OXIDOREDUCTASE LIPOXYGENASE-3 2.1
1u4s OXIDOREDUCTASE L-LACTATE DEHYDROGENASE 2
1t24 OXIDOREDUCTASE L-LACTATE DEHYDROGENASE 1.7
2vj8 HYDROLASE LTA4H PROTEIN 1.8
1lc8 LYASE L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE 1.8
1lag AMINO ACID TRANSPORT LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN 2.06
2plk LYASE LYSINE/ORNITHINE DECARBOXYLASE 2.14
1li2 HYDROLASE LYSOZYME 2
1lmo HYDROLASE (O-GLYCOSYL) LYSOZYME 1.8
3f15 HYDROLASE MACROPHAGE METALLOELASTASE 1.7
2hu6 HYDROLASE MACROPHAGE METALLOELASTASE 1.32
3f16 HYDROLASE MACROPHAGE METALLOELASTASE 1.16
1v5z OXIDOREDUCTASE MAJOR NAD(P)H-FLAVIN OXIDOREDUCTASE 2
1af6 MEMBRANE PROTEIN MALTOPORIN 2.4
1mdl ISOMERASE MANDELATE RACEMASE 1.85
1zgs SUGAR BINDING PROTEIN MANNOSE/GLUCOSE-SPECIFIC LECTIN 2.5
1kwy IMMUNE SYSTEM, SUGAR BINDING PROTEIN MANNOSE-BINDING PROTEIN A 2
1krf HYDROLASE MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 2.2
1a9u TRANSFERASE MAP KINASE P38 2.5
1g49 HYDROLASE MATRIX METALLOPROTEINASE 3 1.9
1jj9 HYDROLASE MATRIX METALLOPROTEINASE 8 2
2ovx HYDROLASE MATRIX METALLOPROTEINASE-9 (EC 3.4.24.35) (MMP- 2
S13 2fu9 HYDROLASE METALLO-BETA-LACTAMASE L1 1.8
1kui HYDROLASE METALLOPROTEINASE 1.5
2gg9 HYDROLASE METHIONINE AMINOPEPTIDASE 1.05
2nq6 HYDROLASE METHIONINE AMINOPEPTIDASE 1 1.5
2ea4 HYDROLASE METHIONINE AMINOPEPTIDASE 2 2.35
1r58 HYDROLASE METHIONINE AMINOPEPTIDASE 2 1.9
1yw9 HYDROLASE METHIONINE AMINOPEPTIDASE 2 1.64
1qxz HYDROLASE METHIONYL AMINOPEPTIDASE 1.68
1p7p LIGASE METHIONYL-TRNA SYNTHETASE 1.8
1hbo METHANOGENESIS METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT 1.78
1e6v OXIDOREDUCTASE METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT 2.7
1dig OXIDOREDUCTASE,HYDROLASE METHYLENETETRAHYDROFOLATE DEHYDROGENASE / 2.2
1ik4 LYASE METHYLGLYOXAL SYNTHASE 2
2aa7 TRANSCRIPTION MINERALOCORTICOID RECEPTOR 2.2
1idt OXIDOREDUCTASE MINOR FMN-DEPENDENT NITROREDUCTASE 2
3cgo TRANSFERASE MITOGEN-ACTIVATED PROTEIN KINASE 10 3
1pmn TRANSFERASE MITOGEN-ACTIVATED PROTEIN KINASE 10 2.2
2b1p TRANSFERASE MITOGEN-ACTIVATED PROTEIN KINASE 10 1.9
1w82 KINASE/INHIBITOR MITOGEN-ACTIVATED PROTEIN KINASE 14 2.2
2baq TRANSFERASE MITOGEN-ACTIVATED PROTEIN KINASE 14 2.8
2rg5 TRANSFERASE MITOGEN-ACTIVATED PROTEIN KINASE 14 2.4
1upk TRANSFERASE MO25 PROTEIN 1.85
1nw7 TRANSFERASE MODIFICATION METHYLASE RSRI 2.1
1kfa IMMUNE SYSTEM MONOCLONAL ANTIBODY LIGHT CHAIN 2.8
1y6r HYDROLASE MTA/SAH NUCLEOSIDASE 2.2
1y6q HYDROLASE MTA/SAH NUCLEOSIDASE 2.2
1nc1 HYDROLASE MTA/SAH NUCLEOSIDASE 2
1yv3 CONTRACTILE PROTEIN MYOSIN II HEAVY CHAIN 2
1sjd LYASE, ISOMERASE N-ACYLAMINO ACID RACEMASE 1.87
1gg5 OXIDOREDUCTASE NAD(P)H DEHYDROGENASE [QUINONE] 1 2.5
1uuv OXIDOREDUCTASE NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT 1.65
1r1h HYDROLASE NEPRILYSIN 1.95
1jpa TRANSFERASE NEURAL KINASE, NUK=EPH/ELK/ECK FAMILY RECEPTOR- 1.91
1xog HYDROLASE NEURAMINIDASE 2.8
2htu HYDROLASE NEURAMINIDASE 2.2
2qwi HYDROLASE NEURAMINIDASE 2
1dmt HYDROLASE NEUTRAL ENDOPEPTIDASE 2.1
1jhu TRANSFERASE NICOTINATE MONONUCLEOTIDE:5,6- 2
1jho TRANSFERASE NICOTINATE MONONUCLEOTIDE:5,6- 2
1d0v TRANSFERASE NICOTINATE MONONUCLEOTIDE:5,6- 1.9
1l4f TRANSFERASE NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE 2.1
1l5l TRANSFERASE NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE 2
1l5k TRANSFERASE NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE 2
1l4m TRANSFERASE NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE 2
3e7t OXIDOREDUCTASE NITRIC OXIDE SYNTHASE, INDUCIBLE 2.6
1r35 OXIDOREDUCTASE NITRIC OXIDE SYNTHASE, INDUCIBLE 2.3
3e65 OXIDOREDUCTASE NITRIC OXIDE SYNTHASE, INDUCIBLE 2.05
3b3m OXIDOREDUCTASE NITRIC-OXIDE SYNTHASE 1.95
1mmw OXIDOREDUCTASE NITRIC-OXIDE SYNTHASE, BRAIN 2
1fk4 LIPID TRANSPORT NONSPECIFIC LIPID-TRANSFER PROTEIN 1.8
S14 1qxa HYDROLASE NPQTN SPECIFIC SORTASE B 2.5
1gt3 LIPOCALIN ODORANT-BINDING PROTEIN 1.8
1hn2 PROTEIN BINDING ODORANT-BINDING PROTEIN 1.8
1hqp SIGNALING PROTEIN ODORANT-BINDING PROTEIN 2.3
1jet COMPLEX (PEPTIDE TRANSPORT/PEPTIDE) OLIGO-PEPTIDE BINDING PROTEIN 1.2
1f3t LYASE ORNITHINE DECARBOXYLASE 2
1km3 LYASE OROTIDINE 5'-PHOSPHATE DECARBOXYLASE 1.5
1lp6 LYASE OROTIDINE MONOPHOSPHATE DECARBOXYLASE 1.9
1olt OXIDOREDUCTASE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III 2.07
1oo6 OXIDOREDUCTASE OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE 2
1icu OXIDOREDUCTASE OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE 1.8
1jn5 TRANSPORT PROTEIN P15 2.8
1fjl TRANSCRIPTION/DNA PAIRED PROTEIN 2
1cvz HYDROLASE PAPAIN 1.7
1hkd PLANT LECTIN PEA LECTIN ALPHA CHAIN 2.09
2z71 HYDROLASE PENICILLIN ACYLASE 2.6
1fxv HYDROLASE PENICILLIN ACYLASE 2.25
1kec HYDROLASE PENICILLIN ACYLASE ALPHA SUBUNIT 2.3
1k5s HYDROLASE PENICILLIN G ACYLASE ALPHA SUBUNIT 2.43
1gm9 HYDROLASE PENICILLIN G ACYLASE ALPHA SUBUNIT 1.8
1ppm HYDROLASE(ACID PROTEINASE) PENICILLOPEPSIN 1.7
1h61 FLAVOENZYM PENTAERYTHRITOL TETRANITRATE REDUCTASE 1.4
1gvq FLAVOENZYME PENTAERYTHRITOL TETRANITRATE REDUCTASE 2
1m21 HYDROLASE PEPTIDE AMIDASE 1.8
1szz HYDROLASE PEPTIDE DEFORMYLASE 3.3
1lry HYDROLASE PEPTIDE DEFORMYLASE 2.6
1icj HYDROLASE PEPTIDE DEFORMYLASE 1.9
1ix1 HYDROLASE PEPTIDE DEFORMYLASE 1.85
2f4o HYDROLASE PEPTIDE N-GLYCANASE 2.26
1e8k ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 3 1.9
1hsr OXIDOREDUCTASE PEROXIDASE 1.6
1gwt OXIDOREDUCTASE PEROXIDASE C1A 1.7
1k7l TRANSCRIPTION PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA 2.5
2d81 HYDROLASE PHB DEPOLYMERASE 1.66
1ltz OXIDOREDUCTASE PHENYLALANINE-4-HYDROXYLASE 1.4
2rhs LIGASE PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN 2.2
2rhq LIGASE PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN 2.2
1n7i TRANSFERASE PHENYLETHANOLAMINE N-METHYLTRANSFERASE 2.8
1hnn TRANSFERASE PHENYLETHANOLAMINE N-METHYLTRANSFERASE 2.4
1ow4 TRANSPORT PROTEIN PHEROMONE BINDING PROTEIN 1.6
3bjh PHEROMONE BINDING PROTEIN PHEROMONE-BINDING PROTEIN ASP1 1.6
1e90 PHOSPHOINOSITIDE 3-KINASE GAMMA PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT 2.7
1uw5 TRANSPORT PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA 2.9
2chz TRANSFERASE PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE 2.6
1gym HYDROLASE (PHOSPHORIC DIESTER) PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C 2.2
1nhx LYASE PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC 2.1
1dqr ISOMERASE PHOSPHOGLUCOSE ISOMERASE 2.5
1xtb ISOMERASE PHOSPHOGLUCOSE ISOMERASE 2
1mf4 HYDROLASE PHOSPHOLIPASE A2 1.9
1db4 HYDROLASE/HYDROLASE INHIBITOR PHOSPHOLIPASE A2 2.2
S15 1qll NEUROTOXIN PHOSPHOLIPASE A2 2.04
1t37 HYDROLASE PHOSPHOLIPASE A2 ISOFORM 3 2.6
1oxr HYDROLASE PHOSPHOLIPASE A2 ISOFORM 3 1.93
2b00 HYDROLASE PHOSPHOLIPASE A2, MAJOR ISOENZYME 1.85
1kqu HYDROLASE PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED 2.1
1pcj ISOMERASE PHOSPHOMANNOMUTASE 2
1vlh TRANSFERASE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE 2.2
1h1t TRANSFERASE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE 1.78
1s4r PHOTOSYNTHESIS PHOTOACTIVE YELLOW PROTEIN 1.9
6prc PHOTOSYNTHETIC REACTION CENTER PHOTOSYNTHETIC REACTION CENTER 2.3
1phh OXIDOREDUCTASE P-HYDROXYBENZOATE HYDROXYLASE 2.3
1iuu OXIDOREDUCTASE P-HYDROXYBENZOATE HYDROXYLASE 2
1vj9 HYDROLASE PLASMINOGEN ACTIVATOR, UROKINASE 2.4
1sc8 HYDROLASE PLASMINOGEN ACTIVATOR, UROKINASE 2.4
1z1r HYDROLASE POL POLYPROTEIN 1.85
1f7q VIRAL PROTEIN, HYDROLASE POL POLYPROTEIN 2.26
1pax TRANSFERASE POLY(ADP-RIBOSE) POLYMERASE 2.4
1g2a HYDROLASE POLYPEPTIDE DEFORMYLASE 1.75
1wkr HYDROLASE POLYPOROPEPSIN 1.3
1xuz BIOSYNTHETIC PROTEIN POLYSIALIC ACID CAPSULE BIOSYNTHESIS PROTEIN 2.2
1jxm STRUCTURAL PROTEIN POSTSYNAPTIC DENSITY PROTEIN 2
1q5o TRANSPORT PROTEIN POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED 2.3
2zsi HORMONE RECEPTOR PROBABLE GIBBERELLIN RECEPTOR GID1L1 1.8
1o5q LYASE PROBABLE METHYLISOCITRATE LYASE 2.3
1xg3 LYASE PROBABLE METHYLISOCITRATE LYASE 1.9
1w1a HYDROLASE PROBABLE POLYSACCHARIDE DEACETYLASE PDAA 2.25
1t9m OXIDOREDUCTASE PROBABLE PYRIDOXAMINE 5'-PHOSPHATE OXIDASE 1.9
1sr7 TRANSCRIPTION PROGESTERONE RECEPTOR 1.46
1uoo HYDROLASE PROLYL ENDOPEPTIDASE 2.35
2bkl HYDROLASE PROLYL ENDOPEPTIDASE 1.5
1diy OXIDOREDUCTASE PROSTAGLANDIN H2 SYNTHASE-1 3
1rv7 HYDROLASE PROTEASE 2.7
1rq9 HYDROLASE PROTEASE 2.6
2psv HYDROLASE PROTEASE 1.75
3bxs HYDROLASE PROTEASE 1.6
1mtb HYDROLASE/HYDROLASE INHIBITOR PROTEASE RETROPEPSIN 2.5
1sa5 TRANSFERASE PROTEIN 2.6
1d7s LYASE PROTEIN (2,2-DIALKYLGLYCINE DECARBOXYLASE 2.05
1b0k LYASE PROTEIN (ACONITASE) 2.5
1bx4 TRANSFERASE PROTEIN (ADENOSINE KINASE) 1.5
1ch8 LIGASE PROTEIN (ADENYLOSUCCINATE SYNTHETASE) 2.5
1cg1 LIGASE PROTEIN (ADENYLOSUCCINATE SYNTHETASE) 2.5
1b9z HYDROLASE PROTEIN (BETA-AMYLASE) 2.1
11bg HYDROLASE PROTEIN (BOVINE SEMINAL RIBONUCLEASE) 1.9
1cf8 CATALYTIC ANTIBODY PROTEIN (CATALYTIC ANTIBODY 19A4 (LIGHT CHAIN)) 2.7
1cgk TRANSFERASE PROTEIN (CHALCONE SYNTHASE) 1.84
1eei TOXIN PROTEIN (CHOLERA TOXIN B) 2
1c1l SUGAR BINDING PROTEIN PROTEIN (CONGERIN I) 1.5
1byg TRANSFERASE PROTEIN (C-TERMINAL SRC KINASE) 2.4
1bvy OXIDOREDUCTASE PROTEIN (CYTOCHROME P450 BM-3) 2.03
S16 1b5d TRANSFERASE PROTEIN (DEOXYCYTIDYLATE HYDROXYMETHYLASE) 2.2
1boz OXIDOREDUCTASE PROTEIN (DIHYDROFOLATE REDUCTASE) 2.1
1eef TOXIN PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN) 1.8
1qs4 TRANSFERASE PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)) 2.1
1b0r SIGNALING PROTEIN PROTEIN (HLA-A*0201) 2.9
1yei IMMUNE SYSTEM PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)) 1.9
1yej IMMUNE SYSTEM PROTEIN (IG ANTIBODY D2.3 (LIGHT CHAIN)) 1.85
1bmq HYDROLASE PROTEIN (INTERLEUKIN-1 BETA CONVERTASE) 2.5
1bl7 TRANSFERASE PROTEIN (MAP KINASE P38) 2.5
1evh CONTRACTILE PROTEIN PROTEIN (MENA EVH1 DOMAIN) 1.8
3mat HYDROLASE PROTEIN (METHIONINE AMINOPEPTIDASE) 2
1b59 HYDROLASE PROTEIN (METHIONINE AMINOPEPTIDASE) 1.8
1b62 DNA MISMATCH REPAIR PROTEIN (MUTL) 2.1
1f6t TRANSFERASE PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE) 1.92
1b40 PEPTIDE BINDING PROTEIN PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN) 2.2
1b3g PEPTIDE BINDING PROTEIN PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN) 2
1b46 PEPTIDE BINDING PROTEIN PROTEIN (OLIGO-PEPTIDE BINDING PROTEIN) 1.8
1bs4 HYDROLASE PROTEIN (PEPTIDE DEFORMYLASE) 1.9
1cj2 OXIDOREDUCTASE PROTEIN (P-HYDROXYBENZOATE HYDROXYLASE) 2.8
1c85 HYDROLASE PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 2.72
1c84 HYDROLASE PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 2.35
1c87 HYDROLASE PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 2.1
1bzc HYDROLASE PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) 2.35
1biw HYDROLASE PROTEIN (STROMELYSIN-1 COMPLEX) 2.5
1b8y HYDROLASE PROTEIN (STROMELYSIN-1) 2
1caq HYDROLASE PROTEIN (STROMELYSIN-1) 1.8
1qf2 HYDROLASE PROTEIN (THERMOLYSIN) 2.06
1qf1 HYDROLASE PROTEIN (THERMOLYSIN) 2
1qbo HYDROLASE PROTEIN (TRYPSIN) 1.8
1c5w BLOOD CLOTTING PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR) 1.94
1f3l TRANSFERASE PROTEIN ARGININE METHYLTRANSFERASE PRMT3 2.03
1n9a TRANSFERASE PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT 3.2
1o1r TRANSFERASE PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT 2.3
1ld8 TRANSFERASE PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT 1.8
1ptr PHOSPHOTRANSFERASE PROTEIN KINASE C DELTA TYPE 2.2
1exc STRUCTURAL GENOMICS PROTEIN MAF 2.7
1ptt COMPLEX (HYDROLASE/PEPTIDE) PROTEIN TYROSINE PHOSPHATASE 1B 2.9
1aax HYDROLASE PROTEIN TYROSINE PHOSPHATASE 1B 1.9
1pfg HYDROLASE PROTEINASE K 2.5
1pek HYDROLASE PROTEINASE K 2.2
2dqk HYDROLASE PROTEINASE K 1.93
1ecv HYDROLASE PROTEIN-TYROSINE PHOSPHATASE 1B 1.95
1nl9 HYDROLASE PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2.4
1pyn HYDROLASE PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2.2
1b4u DIOXYGENASE PROTOCATECHUATE 4,5-DIOXYGENASE 2.2
2o65 TRANSFERASE PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE 2.85
2o64 TRANSFERASE PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE 2.44
3bpr TRANSFERASE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER 2.8
1o49 SIGNALING PROTEIN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 1.7
1o4k SIGNALING PROTEIN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 1.57
S17 3bme OXIDOREDUCTASE PTERIDINE REDUCTASE 1.8
1e92 PTERIDINE REDUCTASE PTERIDINE REDUCTASE 1 2.2
1v3q TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.8
2isc TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.7
1pr4 TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.4
1rt9 TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.3
1pke TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.3
1ovg TRANSFERASE PURINE NUCLEOSIDE PHOSPHORYLASE 2.2
2gms TRANSFERASE PUTATIVE PYRIDOXAMINE 5-PHOSPHATE-DEPENDENT 1.8
1a99 BINDING PROTEIN PUTRESCINE-BINDING PROTEIN 2.2
2ske TRANSFERASE PYRIDOXAL PHOSPHORYLASE B 2.46
1xz8 TRANSCRIPTION, TRANSFERASE PYRR BIFUNCTIONAL PROTEIN 2.8
1a3w TRANSFERASE PYRUVATE KINASE 3
1pow OXIDOREDUCTASE(OXYGEN AS ACCEPTOR) PYRUVATE OXIDASE 2.5
1h1m OXIDOREDUCTASE QUERCETIN 2,3-DIOXYGENASE 1.9
1h1i OXIDOREDUCTASE QUERCETIN 2,3-DIOXYGENASE 1.75
1q65 TRANSFERASE QUEUINE TRNA-RIBOSYLTRANSFERASE 2.1
1ozq TRANSFERASE QUEUINE TRNA-RIBOSYLTRANSFERASE 1.9
3bll TRANSFERASE QUEUINE TRNA-RIBOSYLTRANSFERASE 1.26
1qap GLYCOSYLTRANSFERASE QUINOLINIC ACID PHOSPHORIBOSYLTRANSFERASE 2.8
2ddq IMMUNE SYSTEM R310 ANTIBODY HEAVY CHAIN 2.35
1vg0 PROTEIN BINDING/PROTEIN TRANSPORT RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT 2.2
1rrp COMPLEX (SMALL GTPASE/NUCLEAR PROTEIN) RAN 2.96
1itu HYDROLASE RENAL DIPEPTIDASE 2
2g1n HYDROLASE RENIN 2.9
2g26 HYDROLASE RENIN 2.1
1fcx GENE REGULATION RETINOIC ACID RECEPTOR GAMMA-1 1.47
1h9u NUCLEAR RECEPTOR RETINOID X RECEPTOR, BETA 2.7
1x8j TRANSFERASE RETINOL DEHYDRATASE 2.35
1aqb RETINOL TRANSPORT RETINOL-BINDING PROTEIN 1.65
1b6l HYDROLASE/HYDROLASE INHIBITOR RETROPEPSIN 1.75
1tvr ASPARTYL PROTEASE REVERSE TRANSCRIPTASE 3
1s1t TRANSFERASE REVERSE TRANSCRIPTASE 2.4
1rud VIRUS RHINOVIRUS 14 2.9
1kzl TRANSFERASE RIBOFLAVIN SYNTHASE 2.1
1rnc HYDROLASE(ENDORIBONUCLEASE) RIBONUCLEASE A 1.5
1ucd HYDROLASE RIBONUCLEASE MC 1.3
1eow HYDROLASE RIBONUCLEASE PANCREATIC 2
1rgk HYDROLASE(ENDORIBONUCLEASE) RIBONUCLEASE T1 1.87
1m0s ISOMERASE RIBOSE-5-PHOSPHATE ISOMERASE A 1.9
1gis HYDROLASE RIBOSOME-INACTIVATING PROTEIN ALPHA- 1.7
1wdd LYASE RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN 1.35
1yvz VIRAL PROTEIN RNA DEPENDENT RNA POLYMERASE 2.2
2gc8 TRANSFERASE RNA-DIRECTED RNA POLYMERASE 2.2
1q9t IMMUNE SYSTEM S25-2 FAB (IGG1K) LIGHT CHAIN 1.74
1fq4 HYDROLASE SACCHAROPEPSIN 2.7
1mxc TRANSFERASE S-ADENOSYLMETHIONINE SYNTHETASE 3
1std LYASE (CARBON-OXYGEN) SCYTALONE DEHYDRATASE 2.9
2pmo TRANSFERASE SER/THR PROTEIN KINASE 2.9
1bcs COMPLEX (SERINE PROTEASE/INHIBITOR) SERINE CARBOXYPEPTIDASE II 2.08
S18 1kkp TRANSFERASE SERINE HYDROXYMETHYLTRANSFERASE 1.93
2ywp TRANSFERASE SERINE/THREONINE-PROTEIN KINASE CHK1 2.9
2cgv TRANSFERASE SERINE/THREONINE-PROTEIN KINASE CHK1 2.6
2cgu TRANSFERASE SERINE/THREONINE-PROTEIN KINASE CHK1 2.5
2cgw TRANSFERASE SERINE/THREONINE-PROTEIN KINASE CHK1 2.2
1nvs TRANSFERASE SERINE/THREONINE-PROTEIN KINASE CHK1 1.8
3f2n TRANSFERASE SERINE/THREONINE-PROTEIN KINASE HASPIN 1.8
1e7f PLASMA PROTEIN SERUM ALBUMIN 2.43
1u8a TRANSFERASE SHIKIMATE KINASE 2.15
1e6w DEHYDROGENASE SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE 1.7
2f11 HYDROLASE SIALIDASE 2 2.57
1zbc SIGNALING PROTEIN SIGNAL PROCESSING PROTEIN 2.29
1bda COMPLEX (SERINE PROTEASE/INHIBITOR) SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR 3.35
1svz IMMUNE SYSTEM SINGLE-CHAIN FV FRAGMENT 1696 1.89
1sbf LECTIN SOYBEAN AGGLUTININ 2.43
1sqc ISOMERASE SQUALENE-HOPENE CYCLASE 2.85
1a2u NUCLEASE STAPHYLOCOCCAL NUCLEASE 2
2rtl BIOTIN-BINDING PROTEIN STREPTAVIDIN 1.41
1vwd COMPLEX (BIOTIN-BINDING STREPTAVIDIN 1.87
1rxh UNKNOWN FUNCTION STREPTAVIDIN 2.9
1lcz UNKNOWN FUNCTION STREPTAVIDIN 1.95
1g05 HYDROLASE STROMELYSIN-1 PRECURSOR 2.45
1d8m HYDROLASE STROMELYSIN-1 PRECURSOR 2.44
1d8f HYDROLASE STROMELYSIN-1 PRECURSOR 2.4
1d7x HYDROLASE STROMELYSIN-1 PRECURSOR 2
1bh6 HYDROLASE SUBTILISIN DY 1.75
1eax HYDROLASE SUPPRESSOR OF TUMORIGENICITY 14 1.3
223l HYDROLASE T4 LYSOZYME 1.9
188l HYDROLASE (O-GLYCOSYL) T4 LYSOZYME 1.8
1ork TRANSCRIPTION REGULATION TETRACYCLINE REPRESSOR 2.4
2vpr TRANSCRIPTION REGULATOR TETRACYCLINE RESISTANCE REPRESSOR PROTEIN 2.49
1pe8 HYDROLASE THERMOLYSIN 1.8
1ks7 HYDROLASE THERMOLYSIN 1.7
1kjo HYDROLASE THERMOLYSIN 1.6
1lnc HYDROLASE (METALLOPROTEASE) THERMOLYSIN 1.8
5tln HYDROLASE (METALLOPROTEINASE) THERMOLYSIN 2.3
1tlp HYDROLASE (METALLOPROTEINASE) THERMOLYSIN 2.3
1tmn HYDROLASE (METALLOPROTEINASE) THERMOLYSIN 1.9
1tr5 HYDROLASE THERMONUCLEASE 2.1
1g4s TRANSFERASE THIAMIN PHOSPHATE SYNTHASE 1.7
1g6c TRANSFERASE THIAMIN PHOSPHATE SYNTHASE 1.4
1ig0 TRANSFERASE THIAMIN PYROPHOSPHOKINASE 1.8
2qry TRANSPORT PROTEIN THIAMINE-BINDING PERIPLASMIC PROTEIN 2.25
1q4s HYDROLASE THIOESTERASE 1.95
1tkg LIGASE THREONYL-TRNA SYNTHETASE 1.5
1ca8 COMPLEX (SERINE PROTEASE/INHIBITOR) THROMBIN 2.1
1bb0 COMPLEX (SERINE PROTEASE/INHIBITOR) THROMBIN 2.1
1mu8 HYDROLASE/BLOOD CLOTTING THROMBIN 2
1mu6 HYDROLASE/BLOOD CLOTTING THROMBIN 1.99
1d9i HYDROLASE/HYDROLASE INHIBITOR THROMBIN 2.3
S19 1uvs SERINE PROTEASE THROMBIN 2.8
2v3o BLOOD CLOTTING THROMBIN HEAVY CHAIN 1.79
2v3h BLOOD CLOTTING THROMBIN HEAVY CHAIN 1.79
1riw HYDROLASE/BLOOD CLOTTING THROMBIN LIGHT CHAIN 2.04
1ki4 PHOSPHOTRANSFERASE THYMIDINE KINASE 2.34
1ki2 PHOSPHOTRANSFERASE THYMIDINE KINASE 2.2
1osn TRANSFERASE THYMIDINE KINASE 3.2
1e2j TRANSFERASE THYMIDINE KINASE 2.5
1kim TRANSFERASE THYMIDINE KINASE 2.14
1of1 TRANSFERASE THYMIDINE KINASE 1.95
1e9c PHOSPHOTRANSFERASE THYMIDYLATE KINASE 1.6
1nn0 TRANSFERASE THYMIDYLATE KINASE 1.6
1rts METHYLTRANSFERASE THYMIDYLATE SYNTHASE 3.3
1tdu METHYLTRANSFERASE THYMIDYLATE SYNTHASE 2.1
1axw METHYLTRANSFERASE THYMIDYLATE SYNTHASE 1.7
1juj TRANSFERASE THYMIDYLATE SYNTHASE 3
1ju6 TRANSFERASE THYMIDYLATE SYNTHASE 2.89
1jut TRANSFERASE THYMIDYLATE SYNTHASE 2.7
1i00 TRANSFERASE THYMIDYLATE SYNTHASE 2.5
1bjg TRANSFERASE THYMIDYLATE SYNTHASE 2.3
1f4f TRANSFERASE THYMIDYLATE SYNTHASE 2
2tdd TRANSFERASE (METHYLTRANFERASE) THYMIDYLATE SYNTHASE 2.7
1nje TRANSFERASE (METHYLTRANSFERASE) THYMIDYLATE SYNTHASE 2.3
2tsc TRANSFERASE (METHYLTRANSFERASE) THYMIDYLATE SYNTHASE 1.97
1o28 TRANSFERASE THYMIDYLATE SYNTHASE THYX 2.1
1elr CHAPERONE TPR2A-DOMAIN OF HOP 1.9
1rr2 TRANSFERASE TRANSCARBOXYLASE 5S SUBUNIT 2
1yak TRANSCRIPTION TRANSCRIPTIONAL ACTIVATOR TENA 2.5
1dvz HORMONE/GROWTH FACTOR TRANSTHYRETIN 1.9
1e5a PROTEIN TRANSPORT TRANSTHYRETIN 1.8
1yyt LYASE TRICHODIENE SYNTHASE 2.9
1qd2 HYDROLASE TRICHOSANTHIN 1.86
1ybv OXIDOREDUCTASE TRIHYDROXYNAPHTHALENE REDUCTASE 2.8
1doh OXIDOREDUCTASE TRIHYDROXYNAPHTHALENE REDUCTASE 2.1
1su5 ISOMERASE TRIOSEPHOSPHATE ISOMERASE 2.7
1m7p ISOMERASE TRIOSEPHOSPHATE ISOMERASE 2.4
1lyx ISOMERASE TRIOSEPHOSPHATE ISOMERASE 1.9
1tph TRIOSEPHOSPHATE ISOMERASE TRIOSEPHOSPHATE ISOMERASE 1.8
1sux ISOMERASE TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL 2
1s38 TRANSFERASE TRNA GUANINE TRANSGLYCOSYLASE 1.81
1enu TRANSFERASE TRNA-GUANINE TRANSGLYCOSYLASE 1.95
1k4g TRANSFERASE TRNA-GUANINE TRANSGLYCOSYLASE 1.7
1k4h TRANSFERASE TRNA-GUANINE-TRANSGLYCOYLASE 1.8
1jhg COMPLEX (REGULATORY PROTEIN/PEPTIDE) TRP OPERON REPRESSOR 1.3
1k1l HYDROLASE TRYPSIN 2.5
1k1n HYDROLASE TRYPSIN 2
1v2p HYDROLASE TRYPSIN 1.92
1mbq HYDROLASE TRYPSIN 1.8
1f0t HYDROLASE TRYPSIN 1.8
1v2o HYDROLASE TRYPSIN 1.62
S20 1s6h HYDROLASE TRYPSIN 1.45
1c2f HYDROLASE/HYDROLASE INHIBITOR TRYPSIN 1.7
1xuh SERINE PROTEASE TRYPSIN 2.2
1dpo SERINE PROTEASE TRYPSIN 1.59
1utj HYDROLASE TRYPSIN I 1.83
1nc6 HYDROLASE TRYPSINOGEN 1.9
1g36 HYDROLASE TRYPSINOGEN, CATIONIC 1.9
1a5s COMPLEX (LYASE/INHIBITOR) TRYPTOPHAN SYNTHASE (ALPHA CHAIN) 2.3
2rhg LYASE TRYPTOPHAN SYNTHASE ALPHA CHAIN 2
2clh LYASE TRYPTOPHAN SYNTHASE ALPHA CHAIN 1.7
1tjp LYASE TRYPTOPHAN SYNTHASE ALPHA CHAIN 1.5
1bkc ZN-ENDOPEPTIDASE TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME 2
2hfj HYDROLASE TYPE I POLYKETIDE SYNTHASE PIKAIV 1.95
1kv9 OXIDOREDUCTASE TYPE II QUINOHEMOPROTEIN ALCOHOL DEHYDROGENASE 1.9
1cla TRANSFERASE (ACYLTRANSFERASE) TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE 2.34
2cmc HYDROLASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 2.2
2cm7 HYDROLASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 2.1
2hb1 HYDROLASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 2
2f6y HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 2.15
2f70 HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 2.12
2f6z HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1.7
2f6v HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1.7
2f6t HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1.7
2f71 HYDROLASE TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1.55
1jij LIGASE TYROSYL-TRNA SYNTHETASE 3.2
1h3f LIGASE TYROSYL-TRNA SYNTHETASE 2
1yh8 HYDROLASE UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE 2.7
2udp ISOMERASE UDP-GALACTOSE 4-EPIMERASE 1.8
1nah ISOMERASE UDP-GALACTOSE 4-EPIMERASE 1.8
1r20 HORMONE/GROWTH FACTOR RECEPTOR ULTRASPIRACLE PROTEIN 3
1e9y HYDROLASE UREASE ALPHA SUBUNIT 3
1xxj OXIDOREDUCTASE URICASE 2.8
1q1g TRANSFERASE URIDINE PHOSPHORYLASE PUTATIVE 2.02
1uj2 TRANSFERASE URIDINE-CYTIDINE KINASE 2 1.8
1fv9 BLOOD CLOTTING UROKINASE 3
1gjb BLOOD CLOTTING, HYDROLASE UROKINASE-TYPE PLASMINOGEN ACTIVATOR 1.9
1o5b BLOOD CLOTTING, HYDROLASE UROKINASE-TYPE PLASMINOGEN ACTIVATOR 1.85
1owk HYDROLASE UROKINASE-TYPE PLASMINOGEN ACTIVATOR 2.8
1w11 HYDROLASE UROKINASE-TYPE PLASMINOGEN ACTIVATOR 2
1w0z HYDROLASE UROKINASE-TYPE PLASMINOGEN ACTIVATOR 1.9
1rkg HORMONE/GROWTH FACTOR RECEPTOR VITAMIN D3 RECEPTOR 1.9
1eqa METHYLTRANSFERASE VP39 2.2
1n51 HYDROLASE XAA-PRO AMINOPEPTIDASE 2.3
1h4h GLYCOSIDE HYDROLASE XYLANASE 1.9
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Figure S1. Physicochemical properties for the ligands found in the 990 active sites of the decoy data set, showing how the chosen set of ligands is well contained within the range of properties which are considered to be distinctive for drug-like molecules.
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