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not to develop a live human or human– animal hybrid. The use of SCNT-related technology to treat mitochondrial diseases does not involve cloning, but it does raise the question of whether it is acceptable for ALI JAREKJI/REUTERS children to have three genetic ‘parents’: the mother who donates the egg nucleus, the father who donates the sperm nucleus and another woman who donates the mitochon- drial DNA. The UK Human Fertilisation and Embryology Authority recommended in March that the government authorize the use of this technique to help these patients. We agree with this judgement. Such possibilities need careful considera- tion and public consultation. We believe that the scientific community, which was forced to engage in ethical discussions in the early stages of stem-cell biology, should lead the way. As a first step, scientific academies such as the US National Academy of Sciences or the Australian Academy of Science should organize symposia to foster debate on the ethical ramifications of recent advances and possible new breakthroughs. Scientists should also engage with the public and the broader medical community; for instance, by collabo- rating with patient advocate groups such as the UK Juvenile Diabetes Research Founda- tion, and health-care providers such as the UK National Health Service. This would Observers in Amman, Jordan, watch the transit of Venus across the Sun in June 2012. enable scientists to keep abreast of people’s concerns, and to inform stakeholders of the realistic benefits and limits of their research and the ethical challenges it may bring. The potential benefits of stem-cell for an research are immense. Prospects for trans- formative treatments for conditions such as macular degeneration, type 1 diabetes or Parkinson’s disease are now on the horizon. Arab But without first convincing governments, the public, and funding and regulatory bod- ies that all the possibilities have been thought through and evaluated, headline-catching renaissance results could create a backlash that unnec- essarily delays the tremendous potential Arab Muslim countries need a new generation of benefits of cell therapies. ■ SEE NEWS & VIEWS P.174 to rejoin the forefront of the field, Martin Pera is at the University of says Nidhal Guessoum. Melbourne, Australia. Alan Trounson is at the California Institute for Regenerative Medicine, San Francisco, California, USA. slamic astronomy enjoyed a golden fewer than ten papers in the field each year, e-mails: [email protected]; age from the ninth to the sixteenth and these are hardly cited. Few sizeable [email protected] century ad. Great observatories in telescopes are operational or planned. IBaghdad, , , Samar- The lagging state of astronomy is a par- 1. Tachibana, M. et al. Cell 153, 1228–1238 (2013). 2. Scott, C. T., McCormick, J. B. & Owen-Smith, J. qand and mapped the sky to set adox for a region where funding should Nature Biotechnol. 27, 696–697 (2009). dates for religious and civil festivals and for not be a serious constraint, at least in the 3. The International Stem Cell Initiative Nature Biotechnol. 29, 1132–1144 (2011). astrology. Sophisticated calculations and wealthier Gulf states. The region has sev- 4. Ronen, D. & Benvenisty, N. Curr. Opin. Genet. Dev. models led to advances in mathematics. eral excellent observing locations above 22, 444–449 (2012). Today, Arab astronomy barely registers 2,000 metres that benefit from clear skies. 5. Hayashi, K. et al. Science 338, 971–975(2012). on the world map. Scientific research is Public fascination is strong, as shown by 6. Grieshammer, U., Shepard, K. A., Nigh, A. & Trounson, A. O. Nature Biotechnol. 29, 701–705 weak across the Arab world, and astron- the many local amateur associations and (2011). omy weaker still. Unlike countries of large gatherings for astronomical events, 7. Narbonne, P., Miyamoto, K. & Gurdon, J. B. Curr. comparable gross domestic product per such as eclipses, comet passages or the Opin. Genet. Dev. 22, 450–458 (2012). 8. Tachibana, M. et al. Nature 493, 627–631 (2013). capita, such as Turkey, Israel and South most recent transit of Venus across the 9. Paull, D. et al. Nature 493, 632–637(2013). Africa, most Arab nations are generating Sun in June 2012.

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In my view, astronomy research is determining the direction to (the body motions several metres wide, as well being neglected because of the strongly utili- ) for prayers; and establishing the dates as its library of 400,000 books. Theories tarian Arab Muslim approach to science1. for holy festivals, particularly (the developed there include the ‘Tusi cou- Cultural principles, such as serving the peo- month of fasting) and (the pilgrimage), ple’ that links linear and circular motion, ple first, led Arab nations to build bases in which are set by the observation of the thin which was developed by the the applied sciences in the second half of the crescent of the new . All three still Nasir al-Din al-Tusi in 1247, and later used twentieth century, including petrochemical cause heated arguments among Muslim by in his geometry of engineering and pharmaceuticals. There and scholars. planetary orbits. was also a need for the region to develop its Historically, astronomy was also needed In the fifteenth and sixteenth centuries, infrastructure quickly for navigation at sea and on land. Travel- even more stunning observatories were built. after the departure “Funding lers and sailors learned that the arc of the In the Samarqand (completed of colonial powers. should not Moon indicates the east–west line; the short- in 1429; now known as Observa- Today, subjects such be a serious est shadow of a stick gives the north–south tory), a 30-metre-high building housed ten as theoretical physics constraint, direction; the height of (the Pole ) instruments. These included an armillary are taught widely but at least in the above the horizon gives the latitude of the sphere; an azimuthal for measur- are low cost and are wealthier Gulf place; and Mintaka, a star in Orion’s belt, ing the horizontal angle of the star from the considered low prior- states.” traces the celestial equator. north; and a meridian arc with a 40-metre ity. Astronomy seems Muslim rulers were also guided by astrol- radius, which measured celestial positions to to require expensive buildings, equipment ogy, believing that some days were more pro- within a few arcseconds. The Istanbul obser- and technicians for little tangible return. pitious than others for mundane activities vatory, built in 1577, although smaller, also Another problem is the lack of exper- or stately decisions. Astronomers’ ability to housed ten instruments and had 15 full-time tise in the management of large scientific predict planetary motions and alignments, astronomers2. Sophisticated tables giving the projects — an essential element if obser- eclipses and new and full was a pow- positions of , planets, the Sun and the vatories and research centres are to operate erful weapon in a ruler’s arsenal. Courts had Moon were produced in each. effectively. The few large telescopes that have a resident astronomer, and had a Thus hundreds of stars and constellations been built in the region in the past 50 years time-keeper (). have names, such as Altair, Deneb, have been poorly run, are often inoperable By the thirteenth century, rulers were Vega and Rigel. Today, more than 20 lunar and have produced few results. erecting great observatories such as craters bear the names of Muslim astrono- I call on Arab countries to build a new Maragheh (in present-day ), which mers, including (al-Farghani), generation of observatories. A few medium- was the largest in the world at the time. (al-Battani) and sized telescopes (one- to two-metres in mir- Astronomers and students from around (al-Sufi). The scholar Abu Rayhan al-Biruni ror diameter) costing a few tens of millions the world used its sophisticated instru- (ad 973–1048) used astronomy and trigo- of dollars would allow Arab astronomers ments, which included an armil- nometry to determine Earth’s circumference to join front-line research by searching for lary sphere model of celestial to within 0.3% of today’s accepted value. supernovae, the afterglows of γ-ray bursts, Muslim women participated too: in the tenth variable stars and extrasolar planets. and eleventh centuries, Fatima of Madrid, Universities need to set up degree and daughter of the great Andalusian astrono- international exchange programmes in An eleventh-century mer Maslama al-Majriti, helped her father to astronomy to train and integrate the next , used to produce tables of star and planet positions. generation of Arab astronomers. Such measure celestial In the tenth century, Mariam of was a BRIDGEMAN ART LIBRARY developments would galvanize academic positions, among skilled constructor of for celestial and public interest in fundamental science other functions. surveying. across the region. From the thirteenth century onwards, major centres of learning were lost, such as A GOLDEN PAST those in the Iberian territory of Al-Andalus, Astronomy had a central place in society and conservative rulers and clergy accorded from the early of Islamic civilization. religious knowledge an ever higher place In the early ninth century, a few decades after than worldly science. Universities disap- the founding of Baghdad as the capital of the peared and old places of learning became new Muslim empire, the caliph al-Ma’mun antiquated and disconnected from scien- (ad 786–833) ordered the erection of tific developments in Europe. Observa- two observatories: Shammasiyya near tories were seldom gifted rich, religious Baghdad, and Jabal Qasiyun on the high endowments (awqaf) and thus rarely outskirts of Damascus. Their main aim continued for more than a few years or was to check solar and lunar data in old decades after their establishment. Greek and Indian tables, and to produce Thus the era of great Islamic obser- civil and religious calendars. Facilities vatories came to an end in the later included a quadrant made of marble with part of the sixteenth century, with the a radius of five metres to measure angles on demise of the and the the sky, and a with a central rise of European science. The practice of — the column that casts the shadow — more astronomy, as with other areas of science than five metres high. at the time, depended on the good will of Islamic practice relies on astronomy for the caliph or patron. The Istanbul observa- three purposes: computing prayer times tory was destroyed in 1580, less than three for various locations and dates, which are years after its construction, by a new ruler based on the apparent motion of the Sun; who had been convinced by the religious

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The Ulugh Beg Observatory in Samarqand, , completed in the fifteenth century, was used by several famous Islamic astronomers.

establishment that “prying into the secrets department was established at Cairo Univer- In the past few years, two small obser- of the heavens” was reprehensible and would sity, and the country joined the International vatories have been constructed in other trigger God’s anger2. Astronomical Union (IAU) in 1925 (ref. 5). parts of the Arab world. At an altitude of As a result, no astronomy and little science Sadly, a world map of today’s observatories 2,750 metres, the Oukaimeden Observa- were conducted in Muslim countries until shows just two medium-sized telescopes in tory near Marrakesh in Morocco hosts a the late-nineteenth century. Arab countries: Egypt and Algeria. By com- 50-cm robotic telescope for and parison, South Africa has half a dozen big comet searches. It is run by the Cadi Ayyad ARAB ASTRONOMY TODAY observatories, including the South African University in Marrakesh in collaboration Things got going again when European Large Telescope (SALT) with an 11-metre with Uranoscope de l’Ile de France (a French powers — Britain and France, in particular primary mirror — the largest single optical amateur astronomy association) and the — colonized many parts of the Arab Muslim telescope in the Southern Hemisphere. Marrakesh Amateur Astronomy Associa- world, bringing modern ideas with them, has at least a dozen observatories, including tion. Another observatory in Lebanon, built but education to only a select few. the Indian Astronomical Observatory at by Notre Dame University in Louaize, con- For instance, the Lee AstroPhysical Hanle, which houses a two-metre telescope. tains a 60-cm telescope, which is expected Observatory in Lebanon, named after its The largest telescope to have graced the to begin operating soon. Other Arab coun- British merchant patron, Henry Lee, was Arab world is the 1.88-metre instrument at tries have smaller telescopes, with mirrors built in 1873 by Cornelius Van Alen Van Egypt’s Kottamia Observatory, in the desert of 35–50 cm. Dyck, a passionate professor of astronomy 75 kilometres outside Cairo. The telescope Several Arab states have proposed one- to at what later became the American Uni- was inaugurated in May 1964, but for dec- two-metre telescopes over the years, includ- versity of Beirut. The observatory housed a ades it was under-used or broken. Refur- ing Algeria, Libya, Oman, Saudi Arabia and 25-centimetre telescope, which worked well bished in the 1990s, Egyptian astronomers the United Arab Emirates, but little progress enough until the facility closed in 1980. say that the telescope is now working, has been seen. In 1891, French astronomers built an although few papers have resulted from it. observatory on the hilltops overlooking In Iraq, an ambitious plan to build a RESEARCH ANALYSIS Algiers; it contributed 1,260 photographic world-class observatory in the northern To assess how badly astronomy research is plates of the sky between 1891 and 1911 to high mountains was launched in the 1980s, suffering in the region, I compared publica- the Astrographic Catalogue project, a large envisaging 3.5- and 1.25-metre telescopes, tion and citation data for Arab nations with international effort to map star positions along with a 30-metre radio telescope6. Wars data from Iran, Israel, South Africa and to a high degree of accuracy. In Egypt, the and their resulting damage meant that the Turkey (see ‘Arab astronomy papers’). Arab Helwan Observatory was built in the project was never finished. Plans to relaunch astronomers published fewer papers and had early twentieth century3,4; an astronomy it have been aired, without progress. fewer citations than astronomers in those

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the utilitarian view of science and promote PUBLICATION DATA professional astronomy. Large projects in this field can inspire Arab astronomy papers the science and technology community, the education sector and the public, and To assess the state of Arab astronomy PAUCITY OF PAPERS shift attitudes towards basic research research, I used the Thomson Reuters Web Arab countries produce fewer astronomy in general. of Science to extract publication data for papers than nations with similar GDPs. This can be done by accelerating efforts astronomy and papers for Egypt Arab countries to build high-class observatories, with each Arab country from 1 January 2000 Morocco Comparison one- and two-metre telescopes in several countries to 31 December 2009. For comparison, Sudan countries; establishing astronomy pro- Yemen SOURCE: THOMSON REUTERS WEB OF SCIENCE I collected similar data for authors from Hosts the 1.88-m Algeria Kottamia telescope, the grammes in all public universities; setting Turkey, Iran, Israel and South Africa. Jordan largest in the region. up exchange agreements with interna- Because there were few papers for Tunisia tional institutions; and funding graduate Arab countries, I examined them by hand Saudi Arabia The Lee Observatory students to pursue doctoral programmes at and discarded ones on tangential and Lebanon closed in 1980. universities abroad. Iraq highly theoretical topics. The comparison Syria The Arab world offers ample sites for countries had a greater number of papers, UAE high-quality observatories — several so I examined a random sample of 200 Bahrain mountains have peaks higher than papers from each country and scaled the Kuwait 3,000 metres. Mountain ranges in the totals accordingly. For Arab countries, Libya Arabian peninsula that span the United Mauritania 40–50% of papers were excluded Hosts the 11-m SALT, Oman Arab Emirates, Oman, Saudi Arabia and (reflecting the emphasis on theoretical the largest single-mirror telescope in the Yemen typically enjoy 200–250 clear nights work); for Iran, the percentage was 78%; Qatar Southern Hemisphere. a year. Peaks in the Sinai peninsula reach for Israel, 25%; and for South Africa, 19%. Total Arab up to 2,600 metres, where at least 150 sum- The number of astronomy papers as countries mer nights are clear. Similar suitable sites a proportion of science papers for the South Africa Israel exist in several other countries, from Iraq Arab world is 3 per 1,000 (ranging from Turkey to Morocco. 1 for Qatar to 6 for Bahrain; Yemen has Iran Rich Gulf states could work together to an abnormally high ratio owing to its very set up a world-class observatory. A facil- 0 20 40 60 80 100 120 140 low science production). This is similar to Papers per US$1,000 GDP per capita ity would cost between US$50 million and Iran (2) and Turkey (3), but much lower $100 million, including equipment (a two- than Israel (14) and South Africa (24), the metre telescope, photometer, spectrom- proportions of which are similar to those of papers that were published by authors eter, fast computers and network links, the United States, China, India, Japan, Brazil from Lebanon, which has a population of and a weather station), buildings with and Spain. (In these countries, the range 4 million and a GDP per capita of $9,000, work and meeting rooms, sleeping quar- is 10–25 astronomy papers per 1,000 just 19 were in astronomy. ters and leisure areas, and local roads and publications.) The citation figures are even more infrastructure. The United Arab Emirates, for example, striking. For publications in 2000–09, there Arab universities should cooperate. with a population of 8 million and a gross were 1,507 citations for papers that had a Expert meetings should be convened to pro- domestic product (GDP) per capita of first author from an Arab country and 1,596 duce white papers on restarting astronomy US$46,000 in 2011, published 6,000 for papers that include an author from an in the region. These activities should be sup- science publications over 10 years, but only Arab country (but not a first author). This ported by international organizations such 23 of those were in astronomy. Israel, with is a total of 3,103 citations, compared to as the AUASS and the IAU to put pressure on a similar population but a 30% lower GDP 4,355 for Turkey, which contains one-fifth governments. And it is essential that major per capita than the United Arab Emirates, of the population of the Arab world. Israel’s Arab universities offer degree programmes published a total of 143,000 scientific and South Africa’s citation figures were in astrophysics. papers, of which 1,500 were astronomy 20 times and 9.5 times higher, respectively, Astronomy has a natural place high in the articles. Similarly, of the 13,000 science than those of the Arab world. landscape of Arab Islamic culture. It must be brought . ■ other four countries. The entire Arab world PhD students are rare. Nidhal Guessoum is professor of physics published fewer astronomy papers than Conferences, colloquia and summer and astronomy at the American University Turkey alone, and substantially fewer than schools in astronomy are organized, but of Sharjah, United Arab Emirates. South Africa or Israel. Citation figures are with modest academic impact. The Arab e-mail: [email protected] worse: Arab astronomy papers were cited Union for Astronomy and Space Science less often than Turkey’s, South Africa’s or (AUASS), a supranational organization link- 1. Guessoum, N. Nature Middle East http://dx.doi. org/10/mrn (2012). Israel’s. ing professional astronomers and amateur 2. Sayili, S. The Observatory in (Arno Press, As for degree programmes in astronomy associations of the Arab world, holds meet- 1981). or astrophysics at Arab universities, these ings every two years, but it has not published 3. Hady, A. A. Adv. Space Res. 42, 1800–1805 (2008). can be counted on two hands. Small pro- any proceedings. 4. Hassan, S. M. ‘Kottamia Telescope Upgrading’ grammes exist in Egypt, Jordan, Lebanon, in Developing Basic Space Science World-Wide Saudi Arabia, Sudan and Algeria. Only a few LOOKING FORWARD (eds Wamsteker, W., Albrecht, R. & Haubold, H. J.) 237–240 (Springer, 2004). dozen out of several million students major It is time for governments, funding agencies, 5. Aiad, A. IAU Colloq. 105, 398–399 (1990). in astronomy or astrophysics at undergrad- science-advocacy organizations and uni- 6. Al-Naimiy, H. M. K. Proc. IAU Symp. 260, uate or at master’s level, and home-grown versities of the Arab world to move beyond 429–437 (2011).

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