REHYDRATION REDEFINED

A hypotonic solution with optimal quantities of electrolytes and sugar for fast and effective rehydration

Fictitious people; may not be representative of the entire population.

Helping your patients live life to the fullest HYDRATION AND DEHYDRATION

Your patients may not be aware of just how important hydration is to the human body. When they learn that proper hydration helps maintain a stable body temperature, facilitates circulation, transports nutrients, lubricates tissues and joints and aids digestion, they are more likely to take positive action to stay hydrated.1-5

Definition and pathophysiology of dehydration Dehydration is a condition where a significant decrease in body water and electrolytes is observed. Fluid loss is always accompanied by varying amounts of electrolyte loss.6-8 The clinical manifestations of dehydration are mainly related to intravascular volume depletion as well as the body’s attempts at physiologic compensation.9 Dehydration can result from losing fluid, not replenishing fluid or both.10 While dangerous for infants, small children and older adults, dehydration affects people of all ages.11

6,10-13 RISK FACTORS FOR DEHYDRATION

Excess fluid loss due to: • Diarrhea and vomiting – can lead to sudden losses • Increased urination associated with medical of large amounts of water conditions (such as renal impairment and uncontrolled diabetes) and medications (e.g., diuretics) • Fever – generally the higher the fever, the more extensive the dehydration • Travel – dry cabin conditions in planes, traveler’s Insufficient fluid intake due to: diarrhea and increased exposure to the sun can • Poor thirst mechanism – both older age and exercise all contribute to dehydration can dull the thirst mechanism • Intense heat exposure – hot, humid weather leads • Nausea to increased sweating and fluid loss • Sore throat • Exercise – fluid deficit of as little as 2% body weight can negatively impact mental and physical states, • Pain in the mouth or mouth sores which may in turn impact sports performance • Treatment such as chemoradiation or surgery

VomittingVomittingVomittingVomittingVomittingVomittingDiarrhea FeverFeverFeverFeverFever Fever TravelTravelTravelTravelTravelTravel HeatHeatHeatHeatHeat Heat ExcerciseExcerciseExcerciseExcerciseExcerciseExcerciseExcerciseHangoverHangoverHangoverHangoverHangoverHangover && diarrhea diarrhea& diarrhea& diarrhea& diarrhea& vomitingdiarrhea *

*Although hangovers do not cause fluid loss, proper rehydration will help ease hangover symptoms resulting from an over-intake of alcohol.14 DEHYDRATION: SIGNS AND SYMPTOMS

Mild-to-moderate dehydration2,3,5,15

Dark, strong-smelling Headache Dizziness urine / reduced urine

Increased thirst Dry eyes Dry lips and mouth

Loss of skin elasticity Fatigue Reduced concentration

Confusion, irritability Increase in heart rate Flushed skin and agitation

2,3,5,15 Severe dehydration *

Bluish lips ? Confusion Lack of energy

Cold hands/feet Rapid breathing Unconsciousness

Blotchy skin High fever

*Severe dehydration requires medical attention.

Advise your patients that, for some individuals, dehydration can occur before any signs or symptoms appear. Thirst may not constitute the best early indicator of dehydration.12 Sometimes, a person can be dehydrated even before feeling thirsty.

If mild-to-moderate dehydration is not recognized and corrected by increased oral fluid intake, the volume of fluid circulating in the body will become so low that the patient can eventually develop hypovolaemic shock caused by acute dehydration.2 : INTRODUCING Also suitable for pediatric use A NEW STANDARD IN REHYDRATION Serious rehydration… that tastes great! Made with real fruit juice* Superior taste No preservatives, artificial flavours or colours Available in ready-to-drink and on-the-go powder formats in a range of delicious flavours: • Fruit fusion • Lemonade • Watermelon-apple Formulated based on WHO criteria Proudly Canadian brand

SUPERIOR PRODUCT PROFILE, SUPERIOR REHYDRATION Hydra+ is a hypotonic solution Hypertonic Isotonic Hypotonic H O This means that its osmolality is lower than plasma so water 2 H O H2O cells flows into the cells, allowing for faster rehydration. 2 1800 mg H O 260 mg 58g + With isotonic solutions, there is no net entry or exit of water 1800 mg 2 260 mg 58g + and with hypertonic solutions, water leaves the cells.16 D e hy d ra t i o n e ff e c t Rehydration effect

Hydra+ contains an optimal quantity of electrolytes and sugar 425425 mg mg + + 1800 mg 260 mg 58g + 16g16g 6060 mg mg Hydra+ contains up to

425 mg + 75% less sugar and 4x more electrolytes than regular ElectrolytesElectrolytessports per per drinkslitre litre CaloriesCalories per per litre litre SugarSugar per per litre litre 16g 60 mg

Hydra+Hydra+ (Ready-to-drink) (Ready-to-drink) RegularRegular sports sports drink drink

Electrolytes per litre Calories per litre Sugar per litre

What makes Hydra+ the unique choice Hydra+ (Ready-to-drink) Regular sports drink Hydra+ Pedialyte Hydralyte Pediatric Electrolyte

Made with real fruit juice*

No artificial sweeteners

No preservatives

Natural flavours only

Natural colours only

*Ready-to-drink version version only. only. WHO: World Health Organization Also suitable for pediatric use RECOMMEND FOR OPTIMIZED REHYDRATION Serious rehydration… that tastes great! Made with real fruit juice* Superior taste No preservatives, artificial flavours or colours Optimal quantity of electrolytes and sugar Available in ready-to-drink and on-the-go powder formats in a range of delicious flavours: • Fruit fusion • Lemonade • Watermelon-apple Formulated based on WHO criteria Proudly Canadian brand

Ready-to-drink format: NPN80091476 *Ready-to-drink version only. Powder format: NPN80092000

For more information, visit www.lassondehealthandnutrition.com

References: 1. Puga AM et al. Effects of Drugs and Excipients on Hydration Status. Nutrients 2019;11(3):669. 2. Cambell N. Recognising and preventing dehydration among patients. Nursing Times 2014;110(46):20-1. 3. Dietitians of Canada. Guidelines for drinking fluids to stay hydrated. 2014.4. The Association of UK Dietitians (BDA). Food fact sheet – Fluid. 2017. 5. American Heart Association. Staying Hydrated – Staying Healthy. 2014. 6. Merck Manuals Professional Edition. Dehydration in Children – Pediatrics. 2017. 7. World Health Organization (WHO). Oral rehydration salts – Production of the new ORS. 2006. 8. Merck Manuals Consumer Version. Dehydration. 2019. 9. Lennox HH et al. Dehydration. Medscape. 2018. 10. National Institutes of Health/U.S. National Library of Medicine. Medline Plus. Dehydration. 2017. 11. HealthLink BC. Dehydration. 2019. 12. Mayo Clinic. Dehydration. 2018. 13. Coaching Association of Canada. Fluids for athletes. 2019. 14. NHS (UK) Alcohol support. 2017. 15. NHS (Scotland). Hydration. 2019. 16. Ganong’s Review of Medical Physiology, 26e New York, NY: McGraw-Hill.

Helping your patients live life to the fullest